LOCUS       NC_004557.1            24642 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NC_004557.1 Clostridium tetani E88, complete sequence.
ACCESSION   NC_004557
VERSION     NC_004557.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-03-14 01:24:31
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 2552717
            Orig. end    :: 2577359
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..24642
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="[2562717:2567359]"
                     /cutoff="10000"
                     /detection_rule="(not (POR or POR_N or PFOR_II) and
                     minimum(4, [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF,
                     ETF_alpha, HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and
                     minimum(1, [EC1_2-faecali, ECH1_Enoyl_CoA_DH1,
                     ECH1_Enoyl_CoA_DH2, ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4,
                     Thiolase_C]))"
                     /neighbourhood="10000"
                     /product="acetate2butyrate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..14642
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(not (POR or POR_N or PFOR_II) and
                     minimum(4, [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF,
                     ETF_alpha, HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and
                     minimum(1, [EC1_2-faecali, ECH1_Enoyl_CoA_DH1,
                     ECH1_Enoyl_CoA_DH2, ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4,
                     Thiolase_C]))"
                     /neighbourhood="10000"
                     /product="acetate2butyrate"
                     /protocluster_number="1"
     cand_cluster    1..24642
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(not (POR or POR_N or PFOR_II) and
                     minimum(4, [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF,
                     ETF_alpha, HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and
                     minimum(1, [EC1_2-faecali, ECH1_Enoyl_CoA_DH1,
                     ECH1_Enoyl_CoA_DH2, ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4,
                     Thiolase_C]))"
                     /kind="single"
                     /product="acetate2butyrate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..24642
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="acetate2butyrate"
                     /region_number="7"
                     /rules="(not (POR or POR_N or PFOR_II) and minimum(4,
                     [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF, ETF_alpha,
                     HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and minimum(1,
                     [EC1_2-faecali, ECH1_Enoyl_CoA_DH1, ECH1_Enoyl_CoA_DH2,
                     ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4, Thiolase_C]))"
                     /tool="gutsmash"
     CDS             complement(1367..1651)
                     /locus_tag="ctg1_2474"
                     /transl_table=11
                     /translation="MNIRPLGDRVVIKGIEIEETTKSGIVLPGTAKEKPQEAEVIAVGP
                     GGIVDGKEVKMEVKVGDRVLFSKYAGNEVKVDDVEYTILRQDDILAVLE"
     CDS             1966..2604
                     /locus_tag="ctg1_2475"
                     /transl_table=11
                     /translation="MNNLKTLKEILFSFILSLFFILLSIEIVVNFKYLYYLDIKFLNLE
                     HASNLSYYEIKLNYDYLIDFITSAENIDFNIPSFPSSTEGILHFYEVRDIFTNIKLLFY
                     ITAIISTFIAYYSFKNTNFHIFYYSSHILLTIPLLLITTFVLNFNKVFTYFHKIFFNND
                     FWIFDINKDPIINILPEEFFLHMAIFINIMVIIFAITCRKIYKKSSSLI"
     CDS             complement(2608..3333)
                     /locus_tag="ctg1_2476"
                     /transl_table=11
                     /translation="MKNFKKDIRTWLKNNKNNIILSIIGAIFLYGAYEYYSQYFGVLKN
                     PEEIKRIIMSYGHNSIIAFIALQVIQVVFFFIPGEIIQIAGGYIFDAFYGSLFSIIGIT
                     IGGGIVFSISRFFGKPFVEKIISNKHIKFFSKVLNSDKINYIVFILYLIPGIPKDVLAY
                     ICGISNVKFKDFLIYSSLGRLPGIVISTYFGQNISSKNIPVLVGVSIVTVILIIIGVVK
                     GRSIINNLNKECEKNKKKF"
     CDS             complement(3502..4986)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_2477"
                     /sec_met_domain="Fer4 (E-value: 7.3e-10, bitscore: 35.6,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 0.00053, bitscore: 17.7,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVFENQLKKLKYLVLKEVAKMTLEDRLGEEDIERISFDIIKGDK
                     AEYRCCVYKERAIVYERAKLATGCLPNGQVAEEFVHVEDDDQIIYVIDAACDKCPINKY
                     VVTEACRGCLQHKCMEVCPAGSINRAAGKAYINHETCKECGLCESACPYNAIAEVMRPC
                     RRACPTGALQMNLEDNKATINKEDCINCGSCMSVCPFGAISDKSYIVDITKALKNNKKV
                     YAMVAPAITGQFGKDVSVGKMKNAFKAMGFEDMLEVACGADAVAAHESEEFIERLESGK
                     KYMTTSCCPGFLGYIEKKFPDQLENVSNTVSPMVAIGRMIKKEYEDSVVVFVGPCTAKK
                     AEIKRKGIKDAVDYVMTFEEIAALMGAFEIDPAECEEEDINDGSNYGRGFAQGGGVVSA
                     IQNCIKDKEGIKFNPLRVSGPDQIKRAMIMAKVGKLSENFIEGMMCEGGCIGGPATMVS
                     AVKAKAPLMKFSKSSTIKDVKDNEVLDKYKDINMER"
     CDS             complement(5190..6110)
                     /locus_tag="ctg1_2478"
                     /transl_table=11
                     /translation="VDFKCINNFNKDGIEGIILKGIENFELNHIFDCGQCFRWNRQENG
                     NYIGVAYGKVIEVEKKQDEIILYNTNEKEFEEIWKNYFDLNREYSKIKTILSEDKLLKE
                     AIDYGYGIRILQQEPFEIIISFIISANNRIPMIKKAIEKISRKWGKKLEYKGKEYYGFP
                     SIEKLYNASIEEVEECGTGFRSKYIVDTVSKIYENITTDSLEYNEQFDINYIKTLQDDE
                     CHSALQNFKGIGPKVADCIMLFSMGKDSAFPVDVWVKRAMQHFYLAPDVSLKKIRDFAR
                     EKFGEFSGLSQQYLFYYARENNIIP"
     CDS             complement(6179..7603)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_20"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:Dihydroprymidine dehydrogenase domain II, 4Fe-4S
                     cluster (Score: 151.8; E-value: 1.8e-47)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_2479"
                     /sec_met_domain="Pyr_redox_2 (E-value: 3.7e-37, bitscore:
                     125.4, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_20 (E-value: 7.9e-46, bitscore:
                     151.8, seeds: 204, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRRIRGRSLMDRFKRTPIKVQDAKKRIKNFKEVCLGYTEEEAIK
                     EASRCLNCKNPICVPNCPVAINIPKFIQHVKNREFEEAAKVINEASSLPAICGRVCPQE
                     TQCEGKCVLGVKGEPIAIGKLERFVGDWSRENNVDLSFKGKKKDKKIAVIGAGPAGLTC
                     AGDLAKLGYNVTIFEALHEPGGVLVYGIPEFRLPKDTVVKHEIDNVKKLGVEIETDVIV
                     GRTITVDELLNEEGFHAVFIGSGAGLPKFMGIPGENLNGVFSSNEFLTRNNLMKAYRED
                     YDTPIKVGEKLAVVGGGNVAMDAARTAKRLGAEVHIVYRRSEEEIPARREEVEHAKEEG
                     IIFNLLTNPTEIIGGEDGWVKAMKCIKMELGEPDKSGRRRPVEIEGSEFILDVDTVIMA
                     LGTSPNPLISGTTKGLETDKWGCLVAKDENGETTKRAVFAGGDVVTGAATVILAMEAGK
                     KAAKGIDEFLSDSEKK"
     CDS             complement(7573..8463)
                     /locus_tag="ctg1_2480"
                     /transl_table=11
                     /translation="MYKILDKKLLAPNIYLMDVHVPRIAKSAKPGQFVIVRVDEKSERI
                     PLTICDYDKEKETVTIVFQVVGNSTKKMEELEVGDHFEGFAGPLGQPSELVYEKEEDLR
                     KKNILYIAGGVGSAPVYPQVKWLNSIGVKVDVIIGAKTKEMIILEEEMEKEAGNLYIAT
                     DDGSYGYKGLVTGLLKDLVENKNKKYDLVVTIGPMIMMKFATKATKEYGIKTIASLNTL
                     MVDGTGMCGACRVTVDGKTKFTCVDGPEFDGHLVDFDEALRRQGMYKTEEGKELLERQE
                     REEGHVCHVGLGGDH"
     CDS             complement(8622..9791)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fe-ADH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1035:Iron-containing alcohol dehydrogenase (Score:
                     395.5; E-value: 6.4e-121)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_2481"
                     /sec_met_domain="Fe-ADH (E-value: 2.8e-119, bitscore:
                     395.5, seeds: 219, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRFTIPRDIYYGKGSLEVIKSIKGNKAVIVIGGGSMKRFGFLDK
                     VENYLKEAGIETKLIEGVEPDPSVETVMKGAEIMREFKPDWIISIGGGSPIDAAKAMWL
                     FYEHPDLTFEEAAQKVLCLPELRSKAKFMAIPSTSGTASEVTAFSVITDYKKQIKYPLA
                     DFNLTPDIAIVDPELAETMPAKLTAHTGMDALTHAIEAYVATENTSFTDPLALQAILMV
                     KDYLIKSYEEDKEARERMHEAQCLAGMAFSNALLGITHSMAHKIGAVFDITHGCANAIF
                     LPYVIQFNSKVCEERYANIAKYLGLEGESDKDLVNSLINFIRDLNKKLSIDNSLKEYGI
                     DENEFKEKVEYMAHNAVLDACTGANPRKINEEEMKNMYTYAFNGKDIDF"
     CDS             complement(10001..10849)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: HCDH_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: HCDH"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_2482"
                     /sec_met_domain="HCDH (E-value: 3.1e-35, bitscore: 118.0,
                     seeds: 68, tool: rule-based-clusters)"
                     /sec_met_domain="HCDH_N (E-value: 2.4e-71, bitscore: 236.7,
                     seeds: 60, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKICVLGAGTMGAGIAQAFAAKGYEVVLRDIKDEFVERGIKGIE
                     KGLSKLVSKGRMAQEDMDSILGRIEGTVDLNKAADCDLVVEAAIENMEIKREIFAELDR
                     ICKPETILSSNTSSLSITEIATATNRPDKVIGMHFFNPAPVMKLIEIIRGMATSQETFD
                     AVKEVSVAIGKDPVEVAEAPGFVVNRILIPMINEAIGIYAEGIATAEDIDKAMMLGANH
                     PMGPLALGDLIGLDVCLAIMDVLYTETGDTKYRAHSLLRKYVRAGWLGRKTKKGFHDYS
                     K"
     CDS             complement(10879..11889)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: ETF"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: ETF_alpha"
                     /gene_functions="electron_transport (smcogs)
                     SMCOG1008:Electron-transferring flavoprotein (Score: 186;
                     E-value: 2e-57)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_2483"
                     /sec_met_domain="ETF (E-value: 8.7e-56, bitscore: 186.0,
                     seeds: 129, tool: rule-based-clusters)"
                     /sec_met_domain="ETF_alpha (E-value: 5.2e-37, bitscore:
                     123.1, seeds: 511, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIADYKGVWVFAEQRDGELQKVSLELLGKGREIADKLGVELTAL
                     LLGNKIDSIAEELVAYGADKVIYAQNPLLSHYTTDGYTKVICDLVAEEKPEIILVGATY
                     IGRDLGPRVAARLRTGLTADCTALDVEEGTNNLLMTRPAFGGNLMATIVCGEHRPQMST
                     VRPGVFEKLKKDAGRKGEIKKIEAKLEMSDIRTKVEDVVKITKNVMDIGEAEFLVAGGR
                     GIGSKENFKMLEELAELLGGNVAGSRAAIDNGWIDKDYQVGQTGKTVRPMVYIAVGISG
                     AIQHLAGMQDSDYIIAINKDESAPIMQIADLGLVGDYNKIIPELIAKLKAEKEEN"
     CDS             complement(11910..12689)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: ETF"
                     /gene_functions="electron_transport (smcogs)
                     SMCOG1008:Electron-transferring flavoprotein (Score: 182.2;
                     E-value: 3e-56)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_2484"
                     /sec_met_domain="ETF (E-value: 1.3e-54, bitscore: 182.2,
                     seeds: 129, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIVVCVKQVPDTTEVKIDPVTGTLIREGVPSIMNPDDKNALEEA
                     LRLKESNGAKVTVITMGPQQAESTLREALSMGADEAILISDRAFAGADTLATATALSAA
                     IKKLDYDIVFAGRQAIDGDTAQVGPEIAENLDLPQITYVEKVEVDGEELKVRRAWEDGY
                     ENIRVKTPVLLTAIKELNEPRYMHVAHIFGAFDKEIKTWNADFLEVDKSLLGLKGSPTK
                     VKRSTTKEAKGKGEVISLTPKEAAQCAVAKLKEKHYI"
     CDS             complement(12707..13846)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_2485"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 1e-50, bitscore:
                     169.2, seeds: 49, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 1.6e-26, bitscore:
                     89.7, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 3.2e-40, bitscore:
                     134.7, seeds: 796, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNFALTREQEFVRQMVREFAETEVKPIAAEIDETERFPMENVEKM
                     AKLGMMGIPIPKEYGGAGGDVLSYIIAVEELSKVCGTTGVIVSAHTSLCASLIYEHGTE
                     EQKQKYLVPLAKGEKIGAFGLTEPNAGTDAAGQQSIAIDMGDHYLLNGSKIFITNGGVA
                     DVAVVFAMTDRSKGTRGISAFILEKGMPGFSVGKVEDKMGIRASSTTELIFEDVKVPKE
                     NLIGKEGRGFGIAMKTLDGGRIGIASQALGIAEGALEEAITYMKERKQFGRELYKFQGL
                     SWMMADMKVAIESARLLVYQAAWKKQNKLPYSEEAAMAKLHAANVAMDVTTKVVQLFGG
                     YGYTKDYPVERMMRDAKITEIYEGTSQVQQMVISGSLFR"
     CDS             complement(13860..14642)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: EC1_2-faecali"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_2486"
                     /sec_met_domain="EC1_2-faecali (E-value: 1e-91, bitscore:
                     304.0, seeds: 67, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDFKNLILEKDGKIAVLTINRPDALNALNSELLKELDYAIDCLAE
                     DDEVLAVVLTGAGKAFVAGADIGEMKDLTVSEGRKFGVLGNRVFRKLETLEKPVIAAVN
                     GFALGGGCEISMACDIRIASEKAKFGQPEVGLGITPGFGGTQRLPRLVGPAVAKELIYT
                     ADIIGAEEALRIGLINKIVEKDELLDKAKEMANKIANNAPIAIKLCKSAINRGVQCDID
                     TGIAFEAEVFGECFSTEDQKEGMTAFLEKRKDKCFKNR"
     CDS             complement(14911..15546)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CoA_binding"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_2487"
                     /sec_met_domain="CoA_binding (E-value: 3.8e-26, bitscore:
                     89.0, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKKRNISMAVIKRLPKYHRYLEELLRNEVDRISSKELSKKIGFT
                     ASQIRQDFNCFGDFGQQGYGYNVKELHAQISNILGLTKEYRCIILGGGNIGQAIANYNK
                     FEKLGFRLEAIFDINPKLVGLKIRDIEIKDIDTLEDYLKENNVDVGIICVPSRSAQKVC
                     DILTRNNVKGIWNFAPVDLKVPEGVFTENVHLSENLLTLSYLMNEQEE"
     CDS             15716..17629
                     /locus_tag="ctg1_2488"
                     /transl_table=11
                     /translation="MIILSCKNLTKSYGIDSILHSISFNIKDTEKVGLIGPNGSGKSTL
                     LKILANKLDHDGGEIFVEKNKKIGYLPQHYSIESSKTIYNEMLYVFKSLMDLEEKIADL
                     EEKMNEPYDSSNAEYHDKIIKNYTTAVETYTLRGGYTYKGEINKVLTGLGFEESDFDTP
                     VNILSGGQKTRLALCKLLLINPDILLLDEPTNHLDLDAIEWLEEYLKNHKGTMIIISHD
                     RYFLDSVTNKTMEISNNHLKSFDGNYTKFIEFKKKDYEAQLKAYSIQQSEIKRQEEIIE
                     RYRSFNREKSIRAAESRQKALDKMEKIDKPTVDSSSAKIKFKASIKSGSDVLYIEDLSK
                     SFDEVELFHNINLDIKRGDRSALVGENGRGKTTLFKMIMDEIPADNGTKVLGRNVFIGY
                     YDQEQSDLNPNKTIIDEVWDDFPNMTTTEVRNALASFLFTGDDVFKEISKLSGGEKCRI
                     NLLKLMLSKANFLLLDEPTNHLDIVSREALEDAIVNYDGTVLVISHDRYFLNKVIDKIY
                     ELKKDEIKEYLGNYNYYIEKKKNPSRFEALEENEGMTKTQIKMEKKKKREAEKEQKQIK
                     MKAKNIEELISSKENELLKLQEELCLEEVYSNPDKAQDINLKILNIEKSLEELYNEWEN
                     YL"
     CDS             17937..18908
                     /locus_tag="ctg1_2489"
                     /transl_table=11
                     /translation="MINTKVLATITAISYSVIFGLSFLFTKKALIFATPFQLIAFRFLL
                     AFIFMSILIFSKILKINYENKDIKGLFFLVLMQPIGYFIFETYGLKLSTSSQAGILTAL
                     IPIISSIVAVYILKEIPSKKQWFFIILSVIGVIFIVIMDKNSDSGNSLLGTFLLLGAII
                     CGSFYHVLSRKVSSTFTPIETTYFMMGVGAVTFNFISIITHIKDNDFSNYFHLLYNKDF
                     LIPLLFLGILSSVIAFLFVNFSLCYLEASKCAVFSNLSTVISILAGVLFLDEKIYWYHI
                     IGSITILIGVYFTNYLNSNNKNTSSEKDVDLDESNKERAISK"
     CDS             complement(18952..19764)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) F420_oxidored"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) P5CR_dimer"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1046:NADP oxidoreductase coenzyme F420-dependent
                     (Score: 75.4; E-value: 1.4e-23)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_2490"
                     /sec_met_domain="F420_oxidored (E-value: 6.1e-22, bitscore:
                     75.4, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="P5CR_dimer (E-value: 2.5e-41, bitscore:
                     137.6, seeds: 951, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKSIGFIGCGNMAQAMITGIVTSKIVKGKNVFVSDRDEEKLKYI
                     KDNFNVNTSKSNEEVAEKSDIIILAVKPNKYGEVIEGIKDYVKKDVIIVVIGAGITIDY
                     VEESFKKKLKVIRTMPNTPALVGEGMSAICYNELVEEYDLKVVVDIFKSFGKVEIIEEN
                     LMDAIPAISGSSPAYVYMFIEALADGAVLDGVPRDKAYKMAAQSVLGAAKMVLETGEHP
                     GELKDRVCSPAGTTIEAVYSLEKNNFRGTVMEAMRKCTDKTREMSKRN"
     CDS             complement(19781..20803)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M22"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_2491"
                     /sec_met_domain="Peptidase_M22 (E-value: 1.5e-105,
                     bitscore: 350.0, seeds: 111, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKDIKILAIESSCDETSAAVVINGREVLSNVISSQIDIHEKFGG
                     VVPEVASRKHIEAISLVVQEAIKEANMDYEELDAIAVTYGPGLVGALLVGLQYAKGLSY
                     ALNKPLIGVNHIEGHISANYIQHKDLEPPFLCLVVSGGNTFIVYVENYGEYEIIGETRD
                     DAAGEAYDKVARAIGLGYPGGPKIDKLAKEGNENAIKFPRAKFHEENTLDFSFSGLKSS
                     VLNYLNTMEMKKEEINRADVAASFQKAVVDFLVDNTMKAAKIKKVDEIAVAGGVAANSC
                     LRDTIVKEGEKNNIKILFPSIKLCTDNAAMIGSAAYFQFLKSDFSDLNLNAVPNLKLNK
                     "
     CDS             20988..21602
                     /locus_tag="ctg1_2492"
                     /transl_table=11
                     /translation="MNNYAKIIVKGSPITKSNFKLFNLQGRAILPHNSGKYHDRYAVYE
                     QEIAYEARVQNPNIILSESLIAVLKVYYKSKKRHPDTINITKSIFDGVEKSGVIINDAQ
                     IRRIIVEEFYDKENPRFELELFGESFYSMDYTIKKRDINVKPIEYNPSPNTHNKSPEKI
                     DKKVIGENLCSICGKKVTITDCFSANKGTMKICKECFKKSF"
     CDS             complement(21646..22017)
                     /locus_tag="ctg1_2493"
                     /transl_table=11
                     /translation="MEERILTCIGCPMGCNLNVKLENGEVVDVKGNSCGIGINYAKKEC
                     TNPKRIVTSSVYIEDGEIDILPVKTKEDIPKSKINECMKSLKGLVVKAPVKIGDVIAEN
                     ICDTGVDIVATRTIKKKAV"
     CDS             complement(22020..23285)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_2494"
                     /sec_met_domain="Pyr_redox_2 (E-value: 3.8e-34, bitscore:
                     115.6, seeds: 65, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQEYDIVIIGGGPAGLAAAISAKEEGVDNIVILERDSVLGGILNQ
                     CIHNGFGLHTFKEELTGPEYAQRYIDKVEELNIPYKLDTMVIDLTEDKIITAVNKDEGI
                     IQIKAKSIILAMGCRERPRGALNIPGSRCAGIFTAGTAQKFVNIDGYMPGKEVVILGSG
                     DIGLIMARRMTLEGAKVKAVVELMPYSGGLKRNIVQCLDDFGIPLKLSHTVIDIKGKER
                     LEGVTIAKVDENRRPIEGTEEYIPCDTLLLSVGLIPENELSKKSNVELSRVTNGPVVNE
                     SFETNQEGIFACGNVLHVHDLVDNVSMESHVAGKNAVNYVKGKKTGNSDNPIEVVAEGG
                     VRYTVPKYINSKNVQDFIHVRFRVGNVYTNNYIAVYFDDNREFRMKKRILTPGEMEEVR
                     ITKAMLEKYPSCKKITVKIEEE"
ORIGIN
        1 tttaactatg tcaataccta attttatgtc atgagtttct gaatttaatt tctctacttc
       61 ttttataacc atagcataag ctgttccacc acccggaatt attccttctt caacagctgc
      121 ttttgtagcc gctagagcat cttctattct tagttttctt tcttttaatt cagtttctgt
      181 agctgctcca acctttatta ctgctactcc acctgcaagt tttgcaagtc tttcttgtaa
      241 tttttctcta tcgaattctg atgttgtttc ttcgatttga gcttttattt gatttactct
      301 atcttcaatt tcttttttat ttccttttcc attaactata gtagtagttt ctttagttat
      361 ttttactgac tcagctcttc caagcatatc tactgttaca tcttttagat ctcttcctat
      421 ttcttcagat attacttgac caccagttaa tgtagctata tcttctagca tttcttttct
      481 tctatctcca aatcctggtg ccttaactgc tacacatgta aatgttcctc ttaatttatt
      541 tacaactaat gttgctaatg cttctccttc tatgtcttcg gatatgatta ataatctctt
      601 tccttgttga actatttgtt caagtactgg aagtatttct tgtatattag ttatcttttt
      661 atctgtaatt aaaatgtatg catcatctaa tgaagcttcc attttttctg tatcagtaac
      721 catatatggg ctaacatatc ctctgtcaaa ttgcattcct tcaacaacgt ctaattctgt
      781 tcccatagta ttagattctt ctacagtgat aactccttca ttaccaacct tctccatagc
      841 atctgctata agcttaccaa tttctttatc atcagctgat atagcagcaa ctcttgctat
      901 gtcttctttt ccttcaactg gttttgaaat ttcttttata cccttaactg cttcttcaac
      961 agccatttgt attccacgtc ttacaagcat tggatttgct ccacctgtaa cgtttttaag
     1021 tccttctctt ataattgctt gtgctaataa agttgctgta gttgttccat ctcctgctac
     1081 atcattagtt ttagtagcaa cttcttttac taattgtgct cccatatttt cataagcatc
     1141 ttcaagttct atttctcttg ctattgtaac accatcatta gttataagtg gtgctccaaa
     1201 ctttttatct agaacaacat ttcttccctt tggtcccata gtaactttta ctgtatcagc
     1261 aagaatgtct acaccctttt gcatggatct tcttgcgtct tcaccaaaca ttatactttt
     1321 tgccatttcc atacctccta aatctatcct tataaatttt taacccttat tctaatactg
     1381 ctaaaatatc atcttgtctt aatattgtat attctacatc atctacttta acttcattac
     1441 ctgcatattt tgaaaacaga actctgtctc ctactttaac ttccattttt acttctttac
     1501 catcaacaat tcctcctggt cctacagcta ttacctcagc ttcttgaggt ttttcttttg
     1561 cagttcctgg taaaactatt ccgctttttg tagtttcttc aatttcaatt cccttaataa
     1621 caactctgtc tccaagtggt ctaatattca tttaaacccc tccttaatat attttaaaat
     1681 attaaaattc ttctccttcg attattagca ctcactcata ttgagtgcta atacaattat
     1741 tatgataatt aatagtattt ataatatcaa gtttaaaacc acaacttatt ttgcattaat
     1801 taatcattac tcacaattat atgattatat ctaagtttct tactatgttt ctatgttttt
     1861 ctatgtattt tatttatttt acaaaatata tacatttaca aagcttatta acatacccta
     1921 tactttaatg taacaaatat ttatttaatt ttagaggtat taattatgaa taatttaaag
     1981 acacttaaag aaattttatt ttcttttatt ctatctttat tttttatttt attatctata
     2041 gaaatagtag taaattttaa atacttatat tatttggaca taaaattttt aaacttagaa
     2101 catgcaagta atctttcata ttatgaaata aagctaaact atgattatct tatagatttt
     2161 attacatctg ctgaaaatat agattttaat ataccctctt ttccttcatc tacagaaggt
     2221 atactgcact tttatgaagt aagggatata tttactaata taaaattgtt gttttatata
     2281 actgcaatta tatccacttt tattgcctat tattccttta aaaatactaa ttttcatata
     2341 ttttattaca gttctcatat actattgact ataccattgc ttcttattac cacatttgta
     2401 ttaaatttta ataaagtttt tacttatttt cataagatat tttttaataa tgatttctgg
     2461 atttttgata ttaataaaga tccaattatt aatatattac ctgaagaatt ttttcttcat
     2521 atggctatat ttataaatat aatggttata atttttgcta taacttgtag aaaaatatat
     2581 aaaaaaagct ctagtcttat ataaaaccta gaactttttt ttatttttct cgcattcttt
     2641 atttagatta ttgattatac ttcttccctt taccactcct attataataa gtataactgt
     2701 tactatggat acacctacta atacaggaat attcttagaa cttatattct gtccaaaata
     2761 ggttgaaata actataccag gtaaccttcc taaagaagaa tagattaaaa aatctttaaa
     2821 tttaacatta gatattccac atatatatgc caatacatcc ttaggtatac cagggatcaa
     2881 atacaatata aatacaatgt agttaatttt atctgaattt aatactttac taaaaaattt
     2941 tatatgtttg ttagatatta ttttttccac aaaaggtttt ccaaaaaatc tggaaataga
     3001 aaaaactata cctcctccta tagttatgcc tattatagaa aataagcttc catagaaagc
     3061 atcaaagata tatcctcctg ctatttgtat tatttcacct ggtataaaga aaaatacaac
     3121 ctgtatcact tgtaaagcta taaaagcaat aatactatta tgtccataag acataattat
     3181 tctttttatt tcttctggat tttttagaac tccgaagtat tgtgaataat attcatatgc
     3241 tccatataga aatatagcac cgattataga caaaataata ttatttttat tgttttttag
     3301 ccatgttctt atatcttttt taaaattttt catatactca ccctcagaac atgttctttc
     3361 tattattatt gttcttatta aaatttttat ttactttttc gagtttattt ttacttattt
     3421 atattttgca ttttaaataa aataatgtca ataaaaattt atccctaagg agactttctc
     3481 tccttaggga tattaaaact tctatctttc catattaatg tctttatatt tatctaaaac
     3541 ttcattatct ttaacgtcct ttattgtaga tgatttacta aacttcataa gcggtgcttt
     3601 agcttttact gctgatacca tagtagctgg tcctcctata caaccacctt cacacatcat
     3661 tccctcaata aagttttcgg ataatttacc taccttggcc attatcatag ctcttttgat
     3721 ttgatctggt ccactaactc ttaaaggatt aaatttaatg ccttctttat cctttataca
     3781 attttgtata gcagaaacta ctcctccacc ttgtgcaaaa cctcttccat aattagatcc
     3841 atcatttatg tcttcttctt cgcactctgc tggatctatt tcaaaggcac ccataagtgc
     3901 agctatttct tcaaaagtca tcacataatc tactgcatct ttaatccctt ttctctttat
     3961 ttcagctttt tttgcagtac aaggtcctac aaatacaact acagaatctt catattcctt
     4021 ctttatcatt cttcctatag ctaccattgg agatactgta ttagatacat tctccaattg
     4081 atctggaaac ttcttttcta tataccctaa aaatcctgga caacaagaag ttgtcatata
     4141 tttttttcca ctttcaagtc tttctataaa ttcttcactt tcatgagctg caactgcatc
     4201 tgcaccacaa gctacttcta gcatatcttc aaatcccatt gctttgaaag catttttcat
     4261 tttacctaca gatacatctt taccaaattg tccggttata gcaggggcta ccattgcata
     4321 aactttttta ttatttttta gagctttcgt tatatctact atatagcttt tatcagatat
     4381 agctccaaaa ggacatactg acatacatga tccgcagttt atacaatcct ctttatttat
     4441 tgtagcctta ttatcttcta aattcatttg taacgctcct gttggacaag cccttctaca
     4501 aggtctcata acctctgcta tggcattata aggacatgct gactcacaca atccacattc
     4561 tttacaggtc tcatgattta tatatgcttt tcctgctgct ctgtttatag aacctgctgg
     4621 acatacttcc atacatttat gttgtaaaca tcctctacat gcttctgtta caacatattt
     4681 atttatagga catttatcac aggctgcatc tattacatat attatttgat catcatcttc
     4741 aacatgtaca aattcttctg ctacctgtcc atttggtaaa catcctgttg caagttttgc
     4801 cctttcataa actatggctc tttctttata gacacaacat ctatactcag ctttatcacc
     4861 ttttattata tcaaaagata ttctttctat atcttcctct cctaatctat cttccaaagt
     4921 cattttagct acttctttta atactaagta ctttaatttt tttaattgat tctcaaaaac
     4981 aatcattcta tataatcctc ctaaatataa ttaacaaagc aaatattttt atgataaaaa
     5041 cataaaaatt acttgttaat ttattaacag atacattata acagatatct gaaaaaaatt
     5101 aatacacatt tttctatatc agagtacaaa ttagccgttt aaagttaatt atctctacct
     5161 atatcattca atcgcttttt tatatctatt tacggtatta tattgttttc tctagcataa
     5221 taaaataaat attgttgaga taatccagaa aactctccaa atttttctct agcaaaatct
     5281 cttattttct ttaaagacac atctggtgct aaataaaaat gttgcatagc ccttttaacc
     5341 caaacatcta caggaaatgc agaatctttt cccattgaaa aaagcattat acaatctgcc
     5401 accttaggtc ctatgccttt aaaattttgt aacgcactat gacattcatc atcttgtagc
     5461 gtttttatat aatttatgtc gaactgttca ttatattcca aactatctgt tgtaatattt
     5521 tcatatattt tagatacagt atctacaata tatttacttc taaaaccagt tccacattct
     5581 tctacttctt ctatagaagc attatataat ttttctatgg agggaaaacc ataatattcc
     5641 ttacctttat actccaactt ttttccccat tttctactta ttttttcaat agccttcttt
     5701 atcattggta ttctattatt agcagaaatt atgaatgaaa ttattatttc aaaaggctct
     5761 tgttgtaata ttcttattcc ataaccataa tctatagctt cttttaataa tttatcctca
     5821 cttagtatag ttttaatttt agaatattcc ctgtttaaat caaaatagtt cttccaaatt
     5881 tcttcaaact ctttctcatt tgtgttatat aaaattatct catcttgttt tttttctact
     5941 tctattactt ttccataagc tacacctata taatttccat tttcttgtct attccatcta
     6001 aaacattgcc cacaatcaaa tatatgattt aattcaaagt tttctatccc ttttaaaatt
     6061 attccctcta taccatcttt attaaaatta tttatacatt taaaatccac aataaatcct
     6121 cccatatata ataagtgtga aataattata tttattccac acttattata tcatcttttt
     6181 attttttttc actatcactc aaaaattcat ctattccttt agcagctttt tttcctgctt
     6241 ccatagctag tattacagtt gcagcaccag ttaccacatc tcctcctgca aataccgctc
     6301 ttttagtagt ttctccattt tcatccttag ctactaagca gccccatttg tccgtttcca
     6361 gtccttttgt tgtaccagat attagtggat ttggtgaagt tcctaatgcc attattacag
     6421 tgtctacatc taaaataaat tcagatccct caatttctac tggtcttctt ctgccagatt
     6481 tatcaggttc tcctaactcc atttttatac acttcattgc ctttacccat ccatcttctc
     6541 cacctattat ttctgttgga ttggtaagta gattaaatat tattccctct tcttttgcat
     6601 gctctacttc ttctcttctt gctggtattt cttcttctga ccttctatac actatatgaa
     6661 cttctgcccc aagtctttta gcggttctag cagcatccat agcaacattt ccaccaccta
     6721 ctactgctaa cttttcacct acttttatag gagtatcata atcttctcta taggccttca
     6781 taagattatt tctagttaaa aattcatttg atgaaaatac accatttaag ttttctccag
     6841 gtattcccat gaacttaggt agccctgctc ctgaacctat aaatactgca tgaaaccctt
     6901 cttcatttaa aagttcatcc actgtaattg ttcttccaac tattacatct gtttcaattt
     6961 ctactcctag ttttttaaca ttatctattt catgttttac tacagtatcc tttggcaatc
     7021 taaattctgg tataccatat actaaaactc ctcctggttc atgtaaagct tcaaatatag
     7081 taacattata tccaagttta gctaaatccc ctgcacaggt taatcctgcg ggacctgctc
     7141 ctataactgc aattttttta tctttctttt ttcctttaaa agataaatct acgttatttt
     7201 ccctagacca atctcctaca aatctttcta gctttccaat ggctattggc tctcctttta
     7261 cacctaaaac acatttacct tcacattgag tttcttgagg acatactctt ccacatatag
     7321 ctggtagaga acttgcttcg ttaataactt ttgcagcttc ctcaaattcc ctatttttaa
     7381 catgttgtat aaatttaggt atatttattg ccactggaca atttggcaca caaattggat
     7441 ttttacaatt aagacatctt gaagcttctt taatcgcttc ttcttctgta tatccaagac
     7501 aaacctcttt aaagtttttt attctctttt tggcatcttg aacttttata ggagttcttt
     7561 tgaatctatc cattaatgat ctccccctaa tcctacgtga catacgtgtc cttcttctct
     7621 ttcttgtctt tctaataatt ctttgccttc ttctgtttta tacatacctt gtcttcttag
     7681 ggcctcatca aaatctacta agtgcccatc aaattctggt ccatctacac aggtaaattt
     7741 agttttacca tcaacagtta ctctacaagc tccacacata cctgttccat ctaccattaa
     7801 agtatttaaa ctggctatag tttttattcc atattccttt gtagcttttg ttgcaaattt
     7861 catcattatc ataggtccta ttgttactac taaatcatat tttttatttt tattttctac
     7921 taaatcctta agtaaacctg ttactaatcc tttgtatcca taagaaccat catcggtagc
     7981 tatatataaa ttgccagctt ccttttccat ctcttcttct aaaattatca tttctttagt
     8041 ttttgcacca attattacat ctacttttac tcctatggag tttaaccatt taacttgagg
     8101 atatactgga gctgacccta ctcctccagc tatatacaat atgttctttt ttcttaagtc
     8161 ctcttctttt tcatatacta actctgaagg ttgacctaat ggtcctgcaa atccttcaaa
     8221 atgatctcct acttctaatt cttccatctt ttttgtagaa ttacctacta cttgaaatac
     8281 tatagtaact gtttcttttt ctttatcgta atcacatata gtaagaggaa ttctctcact
     8341 tttttcgtct actcttacta ttacaaattg tcctggctta gctgatttgg caattcttgg
     8401 cacatgcaca tccataaggt aaatatttgg agctaataat tttttatcta atattttata
     8461 catttatttt cctccatatt cattattatt ctcataacat ctatatttat tatataaaac
     8521 tttaatacac ataatcaact catcaataat attgtcatta aattccttaa aaactcccct
     8581 aatcttaatt aagagagttt tttcttcaat ttgttattta tttaaaaatc tatatctttt
     8641 ccattaaatg cataagtata catgttcttc atttcttctt catttatttt tcttgggttt
     8701 gctcctgtgc aagcatctaa tacagcattg tgagccatgt attcaacctt ttctttaaat
     8761 tcattttcat ctattccata ttcttttaat gaattatcta tgcttaattt tttatttaaa
     8821 tccctaatga aatttatcaa tgaatttact aaatctttat ctgattctcc ttctaatcct
     8881 aaatactttg caatatttgc atatctttct tcacaaacct tactattaaa ttgtataaca
     8941 taaggtaaga atattgcatt agcacaacca tgagttatat caaatacagc accaatttta
     9001 tgagccatac tatgagttat tccgagtaat gcattagaaa aagccattcc tgcaagacat
     9061 tgagcttcat gcattctttc tcttgcttct ttgtcttctt cataggattt aattaaataa
     9121 tctttaacca ttaatattgc ctgtaatgct agtggatctg taaagctagt gttttctgta
     9181 gccacataag cttctattgc atgagttaag gcatccatac ctgtatgagc ggtaagttta
     9241 gctggcattg tttctgccaa ttctggatct actatagcta tatctggtgt taaattaaaa
     9301 tctgctaggg gatattttat ttgttttttg tagtctgtta ttactgaaaa agcagttact
     9361 tctgaagctg ttccactggt agatgggata gccataaatt tagctttact tctcaattct
     9421 ggaagacaaa gtactttttg tgcagcttct tcaaaagtta aatcaggatg ttcatagaaa
     9481 agccacatag ctttagctgc atcaattggt gatccgccac ctatagatat tatccaatct
     9541 ggcttaaatt ccctcatgat ttctgcaccc ttcataactg tttctactga aggatctggc
     9601 tctacacctt ctattaattt agtttctata cctgcttcct ttagataatt ttcaacctta
     9661 tctaaaaaac caaatctttt cattgatccg ccaccaatta ctataacggc tttatttccc
     9721 ttaatagatt ttattacctc taatgaccct ttaccataat aaatatctct tggaattgta
     9781 aatcttttca tatttttatc ctccctatat aatctttaca gtcttgatat atttttaaca
     9841 tatatcaaga ttacttttat accaattata cctaagtctt ataattatag atttatttcc
     9901 atattatttt tatgattaaa actaactata ttgttaataa cttaacttaa ataaagttta
     9961 aattaaaagc cactggaatg gtccaatggc ttttattata ttatttagaa tagtcgtgga
    10021 atcccttttt agtctttctt cctaaccatc cagctcttac atattttctt aataatgagt
    10081 gtgctctata tttagtgtct cctgtttctg tgtataaaac atccattata gcaaggcata
    10141 catctaaacc tataagatct cctaatgcta atggtcccat tgggtgattt gcaccaagca
    10201 tcatagcttt atcaatatct tctgctgttg ctataccctc agcataaatt cctatagctt
    10261 cgtttatcat tggaattagt attctattta caacaaaacc tggagcttct gctacttcta
    10321 ctgggtcctt tccaattgct actgaaactt ctttaaccgc atcaaaagtt tcttgtgatg
    10381 tagccattcc tcttattatt tcaataagct tcattactgg agcaggattg aaaaagtgca
    10441 ttcctataac tttatctggt ctattagtag ctgttgctat ttcagttata gataatgatg
    10501 aagtgtttga agataatata gtttctggtt tgcatattct atctaattca gcgaatattt
    10561 ctctttttat ctccatgttt tctatagcag cttctacaac taaatcgcag tcagcagctt
    10621 tatttaaatc aactgttcct tctattctac caagaattga atccatatct tcttgagcca
    10681 ttcttccttt tgacacaagt ttagataatc ctttttctat tccttttatt cctctttcaa
    10741 caaattcgtc ttttatatct cttaaaacta cttcatatcc ttttgctgca aatgcttgag
    10801 ctataccagc tcccattgtt ccagcaccaa gtacacatat ttttttcata ctattcccct
    10861 cctaagatat taagtatatt aattttcttc tttttctgct tttaacttag ctattaattc
    10921 aggtattatt ttgttataat ccccaaccaa tcctaaatca gcaatttgca ttattggagc
    10981 agattcatct ttgtttatag caattatata atctgagtct tgcattccag ctaaatgttg
    11041 gattgctcca gatataccta ctgctatata aaccattggt cttacagttt ttcctgtttg
    11101 tcctacttgg taatctttat ctatccatcc gttgtctata gcagctcttg atcctgctac
    11161 atttccccca agaagttctg caagttcttc taacatttta aagttttctt ttgaacctat
    11221 tcctctacca cctgctacta ggaattcagc ttctcctata tccataacat tcttagttat
    11281 ttttacaacg tcttctacct ttgttcttat atctgacatt tctaatttag cttctatctt
    11341 tttgatttcg ccttttcttc ctgcatcctt tttaagtttt tcaaaaaccc caggtctaac
    11401 tgtagacatt tgtggtctat gttctccaca aactattgtg gccataagat ttccaccaaa
    11461 agctggtctt gtcattagta gattgttagt tccttcttct acgtcaagtg ctgtacaatc
    11521 tgctgtaagt cctgttctta gtcttgctgc aactcttggt cctaaatctc ttcctatata
    11581 tgttgcccct acaagaatta tttcaggttt ttcttcagct acaagatcac atataacttt
    11641 tgtatatccg tctgttgtat agtgacttag tagtggattt tgtgcatata ttactttgtc
    11701 agctccatat gctactaatt cttctgctat gctatctatt ttatttccta aaagaagagc
    11761 tgttaactct actcctagtt tgtctgcaat ttctcttcct tttcctaaaa gttcaagtga
    11821 aactttttga agttcgccat ctctttgttc agcgaatacc caaacacctt tgtaatctgc
    11881 tatattcatt ctttatccct cctattttat tagatgtagt gcttttcctt tagttttgct
    11941 actgcacatt gtgctgcttc ctttggagtt aggcttataa cttcgccttt tccctttgct
    12001 tcttttgttg ttgatctctt aacttttgtt ggagatcctt ttagtccaag aagggattta
    12061 tctacttcta aaaagtctgc attccaagtt tttatttctt tatcaaacgc tccaaatata
    12121 tgagctacgt gcatatatct tggttcatta agttctttta ttgctgttaa aagaactggt
    12181 gttttaactc ttatattttc gtatccatct tcccaagctc ttctaacttt taattcttct
    12241 ccatctactt caactttttc tacataagta atttgaggta agtctaagtt ttctgctatt
    12301 tctggtccaa cttgcgctgt atctccatct atagcttgtc ttccagcaaa tactatatcg
    12361 tagtctagct ttttaatagc tgcacttaat gctgttgctg ttgctaatgt atctgcacct
    12421 gcaaaagctc tatctgatat taatattgct tcatctgctc ccattgataa tgcttctctt
    12481 agagttgatt ctgcttgttg tggtcccatt gttattactg ttaccttagc accattgctt
    12541 tcttttaatc ttaaagcttc ttctagggca tttttatcat ctgggttcat tattgatgga
    12601 acaccttctc ttataagtgt tcctgttact ggatctattt taacttctgt agtatctgga
    12661 acttgcttta cgcaaacaac tatattcatg tattttaacc tccttattat ctaaataagc
    12721 ttcctgaaat aaccatttgt tgaacttgtg aagttccttc atagatttca gttatcttag
    12781 catctctcat cattctttct actggataat cttttgtata tccatatcct ccaaacaatt
    12841 gaacaacttt agttgttaca tccatagcaa cgttagctgc atgtaatttt gccattgctg
    12901 cttcttctga gtatggtagt ttattttgct ttttccatgc tgcttggtaa actaaaagtc
    12961 ttgcactttc tatggctact ttcatgtctg ccatcatcca agataatcct tggaatttat
    13021 aaagttctct tccaaattgt tttctttctt tcatatatgt tatagcttct tctaaggcac
    13081 cttctgctat tcctaaagct tgagatgcta ttcctattct tcctccatct agagttttca
    13141 tagcaattcc aaagcctctt ccttcttttc ctattaagtt ttcctttggt acttttacat
    13201 cttcaaaaat aagttctgtt gttgaagatg ctcttatacc cattttatct tctacttttc
    13261 ctactgaaaa tcctggcatt cctttttcaa gtatgaatgc tgatattcct ctagttcctt
    13321 tacttctatc agtcatagca aatactactg ctacatctgc cactccacca tttgttatga
    13381 atatttttga tccatttaat aaatagtggt ctcccatatc tattgctata ctttgttgtc
    13441 ctgctgcatc tgttccagca ttaggctctg ttaatccaaa ggcccctatt ttctctccct
    13501 ttgctaatgg aactagatat ttttgttttt gttcttctgt tccgtgttca tatattaagc
    13561 ttgcacaaag agatgtatgt gctgatacta taactcctgt tgttccacat acttttgata
    13621 attcttctac agctatgatg taggataata catctccacc tgctccacca tattcttttg
    13681 gtattggaat acccatcata ccaagtttag ccatcttttc tacgttttcc ataggaaatc
    13741 tttctgtttc atcaatttct gcggcaattg gctttacttc tgtttcagca aactctctta
    13801 ccatttgtct tacaaattct tgttctctag ttaatgcaaa attcatttat tcttacctcc
    13861 tatctatttt tgaagcattt atcttttctt ttttcaagaa atgctgtcat accttctttt
    13921 tggtcttctg tagagaagca ttctccaaat acttctgctt caaaagctat ccctgtatct
    13981 atatcacatt gtactcctct gtttatagct gacttacata gttttatagc tataggagca
    14041 ttattagcta tcttattagc catttcttta gctttatcta aaagttcatc cttttctact
    14101 atcttattaa ttaatcctat tcttaatgcc tcttctgcac caattatatc tgctgtatat
    14161 attaattctt tggctactgc tggtccaact aatctaggta acctttgagt tccaccaaat
    14221 ccaggggtta ttcctagccc aacttccggt tgtccaaatt tagccttttc agaagcaatt
    14281 cttatatcac aagccatgga tatttcacaa cctccgccta aagcgaatcc atttactgct
    14341 gcaataactg gtttttctaa ggtttccaac tttctgaata ctctatttcc aagtactcca
    14401 aattttctac cttcacttac agtaagatct ttcatctctc ctatatccgc accagctaca
    14461 aaagcttttc ctgctcctgt aagtactact gctaatactt catcatcttc tgctagacag
    14521 tcaatagcat aatctagttc ttttagcagt tcactattta aagcgtttag agcatcaggt
    14581 ctattaattg ttaaaaccgc tattttacca tccttttcaa ggataagatt tttaaaatcc
    14641 atagtataat tttcctccct actttaaata atttttaaca aataactttg ggattttaca
    14701 atcatctatt atttattaaa ttaattattt gttaatatta taacaaatac actcaaaaaa
    14761 aataaatccc ttttcttaaa tacaattata tactctatct gttttatttt caatataaac
    14821 ttttactaaa tttataataa attaaaaaaa taaaacaaaa agaaggcact tgttgaattt
    14881 ataacaagta cccttacttt tatttaacgt ctattcctct tgttcattca tcaaataact
    14941 taacgttagt aagttctcac ttaaatgtac attctcagta aaaactccct ctggaacctt
    15001 tagatctaca ggagcaaaat tccatattcc ctttacatta tttctagtta aaatgtcgca
    15061 taccttttga gcacttctac taggaacaca tataattcca acatctacat tgttttcttt
    15121 taggtaatct tctaaagtat ctatatcttt tatctctata tctcttatct tcaagcctac
    15181 tagtttaggg tttatatcaa aaatagcttc taacctaaat ccaagttttt caaacttatt
    15241 ataattagct attgcctgcc ctatgttacc tccgcctagt atgatacatc tatactcttt
    15301 ggttaatcct agtatattac ttatttgagc atgaagctcc tttacgttat atccgtatcc
    15361 ttgctgccca aaatcaccaa aacaattaaa atcttgcctt atttgcgatg ctgtaaatcc
    15421 tatctttttg ctaagttcct tagaggaaat cctatccact tcatttctta acagctcttc
    15481 taaataccta tgatatttag gtaatctctt tataactgcc atagaaatat ttcttttctt
    15541 gtccatagtt cacctcttaa gtttaatact atatttttat aattagtagc cattgattat
    15601 atattttatc acaatatata atttcatact atctatatta taacaaattt aaaatacctc
    15661 tacaaaattt tatttttaca tagtagaata ttatagataa ggggtgaata aacaaatgat
    15721 tattttaagt tgtaaaaatc ttactaaaag ttatggtata gatagtattt tacatagtat
    15781 atcttttaac ataaaagata ctgagaaagt aggcttgata ggccctaatg gttctggaaa
    15841 atctacatta ttaaaaatat tagctaataa attagatcat gatggcggag aaatttttgt
    15901 ggaaaaaaat aaaaaaatcg gctatcttcc tcagcattat tccatagaat cttccaaaac
    15961 tatatataac gaaatgttat acgtatttaa aagtcttatg gacttagaag agaaaatagc
    16021 tgatttagaa gagaaaatga atgaacctta tgattcttct aatgcagagt atcatgataa
    16081 aatcattaag aattacacaa ctgctgttga aacatacacg ctaagaggag gatatacata
    16141 caaaggcgag attaataaag ttttaactgg attaggattt gaagaaagcg attttgatac
    16201 ccctgtcaat atattaagtg gaggtcaaaa aactcgatta gctttgtgta aattattgct
    16261 tataaatcca gatatactat tattagatga acctacaaac catttagact tagatgctat
    16321 agaatggcta gaagaatact tgaaaaacca taaaggaacc atgataataa tttcacacga
    16381 cagatacttt ttagattctg ttactaataa aactatggaa atctctaaca atcatcttaa
    16441 atcctttgat ggaaattata caaaatttat agaatttaaa aagaaagatt atgaagctca
    16501 actaaaagct tactcaattc agcaatccga aataaaaaga caagaagaaa ttatagaaag
    16561 atatagatct tttaatagag aaaaaagtat acgggctgca gaaagtagac aaaaggcttt
    16621 agataaaatg gagaaaatag ataagcccac ggtagattct agtagtgcaa aaattaaatt
    16681 taaagcctct attaaaagtg gtagtgatgt tctttatata gaagatttat ccaaaagctt
    16741 tgatgaggta gaacttttcc ataatattaa tttggatata aaaagaggtg acagatctgc
    16801 cctagtaggt gaaaatggtc gtggtaaaac tactcttttt aaaatgataa tggatgaaat
    16861 acccgctgac aatggtacta aagtattggg taggaatgta tttataggat attatgatca
    16921 agaacagtct gatctgaatc ctaataaaac tataatagat gaggtttggg acgatttccc
    16981 taatatgaca actacagaag taagaaatgc cctagcttca tttttattta ctggagatga
    17041 tgtattcaaa gaaatatcta agcttagcgg tggagaaaaa tgtaggataa atcttttaaa
    17101 attaatgtta tctaaggcta actttttact tctagatgag cctacaaatc atttagatat
    17161 agtatctaga gaagctttag aggatgctat agtaaattat gacggaaccg tacttgtaat
    17221 ttctcacgat agatattttt taaataaagt tattgataaa atatatgagt taaaaaaaga
    17281 tgaaatcaaa gagtatttag gtaactacaa ctactatata gaaaagaaga aaaatccttc
    17341 tagatttgaa gctttagaag aaaatgaagg tatgactaaa actcaaatta aaatggagaa
    17401 aaaaaagaag cgtgaggccg aaaaagaaca aaaacaaatt aaaatgaaag ctaaaaatat
    17461 agaagaacta atttcttcta aagaaaatga attgttaaaa ctccaagaag agttatgttt
    17521 agaagaggtt tattctaatc ctgataaagc tcaggatata aacttaaaaa tattaaatat
    17581 agaaaaatct ctagaagaac tttataatga atgggaaaac tacttataat taacagcgaa
    17641 taatgaacaa ctatggatat cttttctcca ctggcattct aaaaaaattt taattgtatg
    17701 atttatatat taagcagttc ttaactaaat aagcgatgtt cagcgaagca accgagccta
    17761 caaaataaaa ttaaagattt tctgtagcac cgcggaagaa aatccactta aattattagt
    17821 tgttcattat tcattgtcca ttgttagctg ttcattaaat aaaaaggttc tcattgataa
    17881 tattcctgtt ttgctataga atagttttta gaatattcta taacaaggag gtttttatga
    17941 ttaataccaa agtattagca actattactg caatttctta ttctgtaatt tttggattaa
    18001 gctttttatt tactaaaaaa gctttaattt ttgctacccc ttttcagcta atagccttta
    18061 ggtttctatt agcttttatt tttatgtcta ttttaatatt ttctaaaatc ttgaaaataa
    18121 attatgaaaa caaggatatt aaaggacttt tttttctggt tttaatgcaa cctataggtt
    18181 attttatttt tgaaacctat ggacttaaac tatctacatc ttcccaggct ggtattttaa
    18241 cagcccttat acctataatt tcatctatag tggctgtata tatcttaaaa gaaattcctt
    18301 ctaaaaaaca atggtttttt attattttat ctgttatagg cgttattttt atagtaatta
    18361 tggataagaa tagtgattct ggaaactcat tattaggcac ttttcttttg cttggagcca
    18421 taatctgtgg ttctttttat catgttcttt caagaaaagt ttcctctact tttactccta
    18481 tagaaactac ttattttatg atgggagtag gtgctgtaac ttttaatttt atttccatta
    18541 ttactcacat taaagataat gattttagca attattttca tttattgtat aacaaagatt
    18601 ttctaatacc tttacttttt ttaggaatac tatcttctgt tatagccttt ttatttgtaa
    18661 atttttctct atgttactta gaagcttcta aatgtgcagt tttctctaat ttgtctactg
    18721 taatttctat attggctggg gttcttttct tagatgaaaa aatatattgg tatcatataa
    18781 ttggttctat aaccatttta ataggagtgt attttacaaa ttatttaaat tcaaataata
    18841 aaaatacttc ctctgaaaaa gatgttgatt tagatgaatc caataaagaa agagctatat
    18901 caaaatgatt ttaaatcatt ttgatatagc tctttttccc atacttagca tttaatttct
    18961 tttagacatt tccctagttt tatcagtaca ttttctcatt gcttccatta cagtccctct
    19021 aaaattattt ttttctaaag agtatactgc ctctattgta gttcctgctg gtgaacaaac
    19081 cctatctttt aactctcctg gatgttcgcc tgtttctaat accatttttg cagctcctaa
    19141 tacagattgt gctgccattt tatatgcttt atctctagga acaccatcta ataccgctcc
    19201 atctgctaaa gcttctataa acatatacac ataggctggt gaagaaccac ttatagctgg
    19261 tattgcatcc ataagatttt cttctataat ttctacttta ccaaaacttt taaatatatc
    19321 tactacaact tttaaatcat attcctcaac taattcatta tagcatatgg cactcatacc
    19381 ttcccctact aaagcaggag tatttggcat agttctaatt acttttaatt tctttttaaa
    19441 agattcttct acataatcta tggttattcc cgctcctata acaactatta ttacatcttt
    19501 ttttacataa tcctttattc cctctattac ctctccatat ttatttggtt taactgccaa
    19561 gataattata tcggacttct ctgctacttc ttcattagat tttgaagtgt tcacattaaa
    19621 attgtctttt atatatttta atttttcttc atctctatcg cttacaaata catttttccc
    19681 cttaactatt tttgaagtca caattcctgt aatcatagcc tgcgccatat ttccacagcc
    19741 tatgaatcct atactttttt ccatatatac ccctccaact ttatttattt aattttaaat
    19801 ttggtactgc atttaaattt aaatctgaaa aatcactttt caaaaattga aaataagctg
    19861 cactacctat cattgccgca ttatctgtgc atagtttaat acttggaaac aatattttta
    19921 tattattttt ttctccttct ttaactatag tatctctaag acaagaattt gctgccactc
    19981 cgcctgctac cgctatttca tctacttttt ttatcttagc agctttcata gtattgtcta
    20041 ctaaaaaatc taccactgcc ttttgaaaag atgctgctac atctgctcta tttatttctt
    20101 cttttttcat ttccatagtg tttaaataat ttaatactga agatttaagt ccactaaagg
    20161 aaaagtctaa agtattttct tcatgaaact tagcccttgg aaattttata gcattttcat
    20221 taccttcttt agctaattta tctattttag gccctcctgg atatcccaat cctatggctc
    20281 ttgctacttt atcataggcc tctcctgcgg catcatctct agtttctcct attatttcat
    20341 attctccata gttttcaaca tatactataa aagtatttcc tccagagacc acaagacata
    20401 aaaaaggtgg ctctaagtcc ttatgttgaa tataattcgc acttatatga ccttctatat
    20461 ggttaactcc aatcaaaggc ttatttaatg cataggatag tcctttagca tactgcaatc
    20521 ctaccaatag tgctcctact aatcctggtc cataggttac agctatagca tctaattctt
    20581 cgtaatccat attagcctct tttattgctt cttgaactac taaagaaatg gcttctatat
    20641 gttttctaga tgctacctct ggaactaccc ctccaaattt ttcgtgtata tctatttgag
    20701 atgaaattac attagataaa acttctctgc cattgattac tacagccgct gatgtttcat
    20761 cacaactact ttcaatagct aatattttta tatctttctc cataaaattt atacctcact
    20821 taaactgttg tttaatttta attcgcttaa aaaattgtcc tctaaaataa tatgttatat
    20881 aatcaatata taattatcaa taataattat actttaatag tatattctaa tcaatgattg
    20941 ttaaagttaa cttaattatt aactatataa aatatgggtg gtttcaaatg aataattatg
    21001 caaaaataat agtgaagggc tctcctatca caaaatctaa ctttaaactt tttaaccttc
    21061 aaggaagggc aatacttcct cataattctg gtaaatacca tgatagatac gctgtatatg
    21121 aacaggaaat tgcttatgaa gcaagggttc aaaatccaaa cataatatta tctgaatctt
    21181 taatagctgt attaaaggtg tactataaaa gcaaaaaaag gcatcctgat actattaaca
    21241 tcacaaaaag tatatttgat ggtgtagaaa aaagtggtgt tataattaat gatgctcaaa
    21301 taagaagaat aatagtggaa gaattttatg ataaagaaaa tccaagattt gaactagaac
    21361 tctttggcga aagtttttat tctatggatt acactataaa aaaaagagat attaacgtaa
    21421 aacctattga atataatcct tctccaaata ctcataataa atccccagaa aaaatagata
    21481 aaaaagttat tggtgaaaac ttatgtagca tctgtggtaa aaaagttaca ataactgatt
    21541 gtttttctgc taataaaggt actatgaaaa tatgtaaaga gtgctttaaa aaatcatttt
    21601 aaagcactct tttatattta aatatattgt atatggatta tctttttaaa ctgctttctt
    21661 ttttatggtt cttgtagcta ctatgtctac acctgtatca catatatttt ctgcaattac
    21721 atctcctatt ttaactggag cttttactac taatcccttt aatgacttca tacattcatt
    21781 tattttactt ttaggtatat cctcttttgt tttcacaggt agtatatcta tttctccatc
    21841 ttctatataa actgatgatg taactattct tttaggatta gtacattctt ttttagcata
    21901 gtttatacct attccacagc tatttccttt aacatctaca acttcgccat tttctagctt
    21961 aacatttaaa ttacagccca taggacagcc tatgcaagtt agaatcctct cttccattac
    22021 tattcctcct ctatttttac agtaatcttc ttgcagctag gatatttctc taacatagct
    22081 tttgttattc ttacttcttc catttcacct ggagtaagta ttcttttttt cattctaaat
    22141 tccctattat catcaaaata aactgctata tagttatttg tatatacatt tccaactcta
    22201 aaccttacat gtataaagtc ttgtacattt ttagaattta tatacttagg cactgtatat
    22261 cttactccac cttcagctac cacttctata ggattatcac tatttccagt tttctttcct
    22321 tttacatagt taactgcatt ttttccagct acatgacttt ccatactaac attatctact
    22381 aaatcatgaa catgtaatac attaccacaa gcaaaaattc cttcttgatt agtttcaaaa
    22441 ctttcattaa ctacaggtcc attagttact cttgataact caacatttga ctttttagac
    22501 aattcatttt caggtattaa acctactgaa agaagtaaag tatcacaagg tatatattct
    22561 tctgtgcctt ctataggtct tctattttca tctaccttag caatagtaac tccttctaat
    22621 ctttcttttc ctttgatatc tataactgta tgacttagtt taagaggtat tccaaagtca
    22681 tctaaacatt gaactatatt tctctttagc cctccagaat aaggcataag ttcaaccact
    22741 gctttaactt ttgcaccttc aagggtcatt cttcttgcca ttataagtcc aatatcacct
    22801 gagcctaaaa taacaacttc ttttcctggc atatatccat ctatattaac aaatttttga
    22861 gctgttccag ctgtaaatat acctgcacat ctactacctg gaatatttaa agcccctctt
    22921 ggtctttctc tacaacccat agcaagtatt attgatttcg cttttatttg tataatacct
    22981 tcatctttat ttaccgctgt tattatctta tcttctgtta aatctatgac catagtatct
    23041 aatttataag gtatatttaa ttcttctact ttatctatat atctttgtgc atattctggg
    23101 cctgtaagct cttctttaaa tgtgtgaagt ccaaaaccat tgtgtatgca ctgatttaat
    23161 ataccaccta aaacactatc tctttctagt attacaatgt tgtctactcc ctcttctttt
    23221 gctgatattg cagcagcaag accagcaggg cctccgccaa taattactat atcatactct
    23281 tgcattaaga tccctccacg cttctaaata ttatccttgt ttctgccacc agtaataagt
    23341 tgtgattctc taccaaattt tgttacatcc tttggtaact tttctaactc cctagatagt
    23401 atttcaacta acttaggagt acagaaacct gcttgacacc ttccagctcc cgctctactt
    23461 cttcttttta ttccatctaa gtccctagca cctagtggtc tttttattgc atccacgatt
    23521 tctgcttccg taaccatttc acacctacag acaacattac catatagagg attttcttta
    23581 actgcttttt ctcgctcttc attattcata tcttcaaatc tcttaactgg ttctcttttt
    23641 ggattaaatt gcttattttt ttctggagaa agtttttcta ctataatttc tcctatcatc
    23701 tcagctattg ctggagcact agataatcct ggagattcta tagctgctac atttataaag
    23761 ttcttagcat cctctacttc tcctatgata aaatcccctg tatgtccctt agctcttaaa
    23821 ccactaaaag atgttattat gaaagatgta ggtacttctt ttatgctcat cttagccttg
    23881 tccaaaatgt agtctaaaga ctccttatct gttgttacat cctctttatc ttcaatatct
    23941 atagcatttg gtcctacaag taaatttccg tccactgtag gagtaacaag aacacctttg
    24001 ccaaattttg ttggtaattg gaatatagtt tttgaaactg tgtccccaac cattttgtca
    24061 aatagacaat attctccctt tcttgggatt atctttattt tattttcact taccatatta
    24121 ttaattacat ccgcataaac tcctgctgca tttataacta tttttgcttc tatatctccc
    24181 tcattcgttt ctataatata tctatcttct ttttttacta tatttttaac ttcagtattt
    24241 aatttaaaat ccacaccgtt ggtgtaagca ttttctgcaa atgctacatt agctctaaat
    24301 ggacacataa taccaccaga tggtaaatgt aaagacgcaa ctacatactc agataaattg
    24361 ggctctaatt ttaatgtttc ttctctattt aatatttcca taccgggtac accatttttt
    24421 tctccttgtt cttttaaaag ctttaactca tctaaatcct tttcatcaaa gcataaaaca
    24481 agagcaccta ttcttttaaa agggaaatcc aactcttctg aaagctcttc atacatagca
    24541 tttcctttta catttaattt agcttttaaa cttccaggct ttggatcttc tcctgggtga
    24601 actatagcac tattagcttt agaagttccc atacctatat ca
//
