LOCUS       NZ_CP076401.1          23725 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP076401.1 Clostridioides difficile strain S-0253 chromosome,
            complete genome.
ACCESSION   NZ_CP076401
VERSION     NZ_CP076401.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-03-13 23:19:58
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 1012815
            Orig. end    :: 1036540
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..23725
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="[1022815:1026540]"
                     /cutoff="10000"
                     /detection_rule="(minimum(3, [AdoMet_dc, Amidinotransf,
                     Arginase, OKR_DC_1, OKR_DC_1_7_arginine, OTCace]) or
                     ((OKR_DC_1_5_ornithine or OKR_DC_1 or Orn_Arg_deC_N) and
                     minimum(1, [Arginase, OTCace, OTCace_N, PAD_porph])))"
                     /neighbourhood="10000"
                     /product="Arginine2putrescine"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..13725
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(3, [AdoMet_dc, Amidinotransf,
                     Arginase, OKR_DC_1, OKR_DC_1_7_arginine, OTCace]) or
                     ((OKR_DC_1_5_ornithine or OKR_DC_1 or Orn_Arg_deC_N) and
                     minimum(1, [Arginase, OTCace, OTCace_N, PAD_porph])))"
                     /neighbourhood="10000"
                     /product="Arginine2putrescine"
                     /protocluster_number="1"
     cand_cluster    1..23725
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(minimum(3, [AdoMet_dc, Amidinotransf,
                     Arginase, OKR_DC_1, OKR_DC_1_7_arginine, OTCace]) or
                     ((OKR_DC_1_5_ornithine or OKR_DC_1 or Orn_Arg_deC_N) and
                     minimum(1, [Arginase, OTCace, OTCace_N, PAD_porph])))"
                     /detection_rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /kind="chemical_hybrid"
                     /product="Arginine2putrescine"
                     /product="Putrescine2spermidine"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="gutsmash"
     region          1..23725
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="Arginine2putrescine"
                     /product="Putrescine2spermidine"
                     /region_number="6"
                     /rules="(minimum(3, [AdoMet_dc, Amidinotransf, Arginase,
                     OKR_DC_1, OKR_DC_1_7_arginine, OTCace]) or
                     ((OKR_DC_1_5_ornithine or OKR_DC_1 or Orn_Arg_deC_N) and
                     minimum(1, [Arginase, OTCace, OTCace_N, PAD_porph])))"
                     /rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /tool="gutsmash"
     CDS             913..2043
                     /locus_tag="ctg1_839"
                     /transl_table=11
                     /translation="MRNECLGIINLNKKGDPAINKLNYGRPIASTPIAGRYRIIDFALS
                     NMINSGITKVGIFAKEKYRSLTDHIGSGKDWDLSRKKGGLSIFSPENTKYRNTYSHREG
                     DIYTILANLDYIEKSEEEYILIAPSYMLCNLNYSQALEYHKKSHNDITIIYKNVNNANK
                     DFAGNLTLNLDSNNRVINVGNNLGKFPRANICMETYIMKREDFVECIYNIVNKGNYCYL
                     EEFIIEEAENMKIGAYEYTGYLKCVNSVESYFEMSKDLLNLEVADELLYSERKIFTKEK
                     NESPTIYTDSAKVENSFIASGCLIEGTVKDSIIFRKVNVEKGTVIENSIVMQNCVIKSN
                     AKLYNAILDKNTSVSNGKELRGDEKYPLVVEKNTNI"
     protocluster    1563..22857
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="[1024377:1025672]"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="2"
                     /tool="gutsmash"
     proto_core      11563..12857
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="2"
     CDS             2072..3514
                     /locus_tag="ctg1_840"
                     /transl_table=11
                     /translation="MKVFYVTAECWPFAKTGGLGDVSYALPKELKKEGVDVRVIMPKYS
                     TIPSYLKDQLKEIAVFSVRVGWRNQYCGLLEMELDGVKFYFIDNEFYFRREDERKSIYG
                     YGDDAERYTFFTDAVLEAISRIDFYPDVIHINDWHTGMLPLILKERYATLEGYKNIKTM
                     YTIHNLQYQGVFDKHVLYDILDLPQKYFDNGDIEYYGSINFMKAGINFADKIITVSPTY
                     ANEIQTSFYGEQLDGLLRKESGKLKGILNGIDYDLNDPAKDKDIFVHYDVDSIDKKVEN
                     KLRLQDILGLKKDSSIPLIGIVSRLVSQKGFDLIAYMMPELMREDLQIVVLGTGEHQYQ
                     SMFNYYDSNFSDKVSARITFNASLAQQIYAASDMFLMPSLFEPCGIGQMLAMRYGSLPI
                     VRETGGLRDTVTPYNKFTGEGNGFSFKNYNAHEMFFCLKNAIKVFKDKEKWIKLVENAM
                     KTDNSWKKSAKEYIETYRDICD"
     CDS             3528..5948
                     /locus_tag="ctg1_841"
                     /transl_table=11
                     /translation="LVTISKKKFKQKFEVKMYSLYAQSIKEATDEQLLNVLCSLLKDEI
                     AKKWVATKLDKKKEVYYFSLEFLIGRQLKSNLLNLNIEEEVREGLSELGINLDDLIEAE
                     VDPALGNGGLGRLAACFLDSMASLNISGQGYGIRYKYGLFEQKFVNGYQVEVPDNWLTE
                     GRYAWETVRPNEATMVKFGGEVELIKEGSHLKVIHKNYLPVMAMPYDIPIIGYQNQCIN
                     TLRLFKSEIPKRDFGELTSNALNYSGSYEEALKHKYYTEEISQVLYPDDSNYAGKLLRL
                     KQEYFFVSAGIQDIIRKYKKNKLNINNLFDKVAIHINDTHPTLCIPELMRVLLDEENLS
                     WDEAWEITKKTVSYTNHTIMSEAMEKWPVSMMKELLPRIYMIIEEINRRYVEELNNKGY
                     DQDRIKRMSIIDCDNINMANLCIVTSHSVNGVAKLHTHILETEVLKDFYQDEPNKFNNK
                     TNGIAHRRWLISSNPQLSNLITDLIGDSWKKDTLQLKNIEKFKNDSSVLQRLDDIKYNN
                     KANLAKFIKDKYDLNVDPSSIFDVQVKRLHAYKRQLLNIFNVLHMYHELLDNPNLNLDP
                     RTFIFGAKAAPGYYLAKCIIKFINSVASTINNDVRVKDKLKVVFLENYGVSLAEIIIPA
                     ANVSEQISTTTKEASGTSNMKFMMNGAITLATLDGANVEICEQVGKENMFLFGLSAEQV
                     LNYNKYGGYSSLDLYHSNMDIKRVVDDLINGFIPNLGEEGRSIYNSLTTYNDEYFVLRD
                     FENYGQAQADINRLYRDKEKWNKMSLVNIANSGFFSSDRTISEYAKDIWFKRV"
     CDS             5953..7818
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Alpha-amylase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_842"
                     /sec_met_domain="Alpha-amylase (E-value: 2.9e-68, bitscore:
                     228.6, seeds: 19, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQSVIEYNSWDKNFKAPFGALKFDEELTICVKVNEGYNIKSISLE
                     INREEEMRTITLNEELDNDKLGKCFCGKIEKFDGTGVYFYYFKVDVEMDGQIKTLFYGK
                     NRDNGYSCEYNYSDINKYQITVYKDFKVPTWYKEGILYHIFVDRFNNGNRSGKVDNPKK
                     NSFIYGNWEDTPMYIKDSQGDVIRWDFHGGNLRGIINKLGYLKKLGVSILYLSPIFEAS
                     SNHKYDTGDYKKIDPMFGDEDTFKELIDKAKEKGISIVLDGVFSHTGADSKYFNMYGNY
                     NSLGAYQSKESPYYSWYMFEEFPQKYKSWWDVKTLPNINELEHSYMDYIIYDNDSVINK
                     WVNMGIKGWRLDVADELPTKFIRELKKELKKADDDSILIGEVWEDASNKISYGQRRSYL
                     LGEELDSVMGYPFRNNMFSFLKGEINSYELCNRYMQIKENYPKESFRSNLNLIGTHDVT
                     RAKTELNDDVDLVKLAVAIQMTFEGVPYIYYGDEAGLCGGVDPDNRRTYPWKNEDEDML
                     NFYRDVIRIRNKNKLLSSGNTEFIYTNNDSVFSFIRVNENNDRMLILVNRSENVESISL
                     CIESSFIEEIPIKYSLKNANSTIQIENNELKVDLDSKSFRIFRVN"
     CDS             8063..8716
                     /locus_tag="ctg1_843"
                     /transl_table=11
                     /translation="MKVDPLTTQVYDYISKKIQNGEYEANQRITESEICKSIGVSRTPA
                     REALTRLAGENLLEKIPNKGFVVKEFQEKEKLDTYSVIGVLDALAGSSALQNLTESDLV
                     KMEELTEMMAVSIKYKNYNSYLKLSNEFHDIYITKSDNQVLVNLLNSLRYNFMSKSYTS
                     DNEDELYKMLTYSNNQHIEVVKSMRENDLENVERILREHWKTIPMEEMKKEKLL"
     CDS             8812..9411
                     /locus_tag="ctg1_844"
                     /transl_table=11
                     /translation="MYPNKEIAIEELEVAGKMNPGPWIKHSYNVANVAKLIAEQCENLN
                     SEKAFVCGLLHDIGRRTGISSVRHIIDGYDYVISKGWDEVARVCLTHSFPVKDIEADIG
                     NKDISKEQYDFINHYLNNLEYNDYDKLIILCDALADANGFCILEKRFVDTTRRYGIYPF
                     SVERWNKTYEYKEYFEKIINKSIYTLLPNIEKSIYY"
     CDS             10001..11476
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Arginine2putrescine: OKR_DC_1_7_arginine"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_845"
                     /sec_met_domain="OKR_DC_1_C (E-value: 4.7e-10, bitscore:
                     37.6, seeds: 113, tool: rule-based-clusters)"
                     /sec_met_domain="OKR_DC_1_7_arginine (E-value: 5.1e-117,
                     bitscore: 388.6, seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDSEFANAVELSYECAPLLESLKEYSEKDIACFDVPGHVKNRGVA
                     ILNKYLGESLMKMDINSSPTMDNVSAPNGIIKNAQDLLAQAYMADEAFFITNGTTQAIH
                     AMILSVIKPGEKVLLPRNIHKSVINALILCGGIPIFIQPEFDEKLGISLNITLEKVRTE
                     IEKDCNIKALFFLNPTYYGVCADLESIIELCHKNNVLVLVDEAHGAHFPFHLDLPPSAI
                     SLGADMVAVSIHKTGGALTQSSALLLNRDNVSFEKVLQSINMLQSTSASYLLMASIDGA
                     RVNLVENGEKQLSKALNLSRYAKSKLNKIDGIKVLSTEILKQKGVKFIDETKLCINVKE
                     LNLTGFEVYDLLYKNFSIQVELGDSYNILALVSIGTNKSDIDRLVKALSIIAKIYRKES
                     TLNEFNMVQINPIIKLNPREAFYAPKESVEINSCIDRICGESIMAYPPGIPIIAPGELI
                     TEEIMEYIIFLKNSNAYLTDVQDKNLDRILVIK"
     CDS             11563..11976
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Arginine2putrescine: AdoMet_dc"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: AdoMet_dc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_846"
                     /sec_met_domain="AdoMet_dc (E-value: 9.3e-40, bitscore:
                     132.9, seeds: 266, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKFETLGRHILVEYYNCDENVLKDPRLIENFMNDSALNAKATIVD
                     SVFHHFNPWGVSGAVIIAESHLTIHTWPEYGYAAADFFTCGDIDPWKSFELLEQLLKSE
                     RSESTEIPRGLTTKIKKYSKKDLGKITHKPEAV"
     CDS             12006..12857
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synt_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synth"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_847"
                     /sec_met_domain="Spermine_synth (E-value: 6.1e-58,
                     bitscore: 193.1, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Spermine_synt_N (E-value: 1.4e-15,
                     bitscore: 54.7, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELWYTEEWTENVRFSIKVNKHLFEGKSQFQRIDVFDSDEFGKFL
                     TIDGLMMVTYKDEFIYHEMITHVPMATNLNIKKVLVIGGGDGGTVRELSRYPQIEKIDM
                     VEIDKMVVDVSKEYMDICSCKLDDKRVSLYFEDGVNFVKCAHDKSYDLIIVDSTDPIGP
                     GEGLFSTDFYKDCYRILTDDGILVNQSESPYFDFNAKEMKRANKKLKQIFPISEVYQAH
                     IPTYPSGHWLFGFASKKLNPVKNQDRNGWEKLSLKTKYYNSDIHLGSFMLPQYVKEMLD
                     EE"
     CDS             12847..13725
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Arginine2putrescine: Arginase"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_848"
                     /sec_met_domain="Arginase (E-value: 1e-77, bitscore: 259.1,
                     seeds: 235, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNNFYHMNTFMSMDKNYEESNLIVFGVGFDGTTSNRPGARFASS
                     SMRKEFYGLETYSPFLDLDLEDYNICDYGDLEISVGSTEQVLKEIYQETYKIVRDSKVP
                     FMIGGEHLVTLPAFKAVHEKYNDIYVIHFDAHTDLREEYNNSKNSHATVIKRIWDIVGD
                     NKIFQFGIRSGTKEEFKFATEEKHTYMEIGGIDTFENIVNMLNGKNIYLTIDLDVLDAS
                     VFPGTGTPEPGGVNYREFQEIFKIIKNSNINIVGCDIVELSPDYDTTGVSTVIACKILR
                     ELCLIISDKIK"
     CDS             complement(13905..14105)
                     /locus_tag="ctg1_849"
                     /transl_table=11
                     /translation="MKNGIVKWFNNEKGFGFISVEGEDDVFVHFSAIQNDGYKTLEEGE
                     KVSFDITQGNRGPQAENVNRI"
     CDS             14572..16062
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1020:4Fe-4S binding domain (Score: 34.7; E-value:
                     3.3e-11)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_850"
                     /sec_met_domain="Fer4_7 (E-value: 2.3e-09, bitscore: 35.5,
                     seeds: 208, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 1.9e-09, bitscore: 34.7,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 0.00028, bitscore: 19.0,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFQFETQIHKLRHDVLTAIARLGKEDNLTREAMDNIQYEIIKGEK
                     PTYRCCVYKERAIISERVNVSMGLQPGQDKIDLDTMDIEEDEQIIYILEAACDSCPINE
                     FTVTDICRGCLAHRCKEACKFGAITHVGGMAYINHELCKACGMCKKACQYDAISEVVRP
                     CKSVCPTNALGFDRENMKAMIHEDKCLNCGACMSACPFGAISDKSLIAPVARKLVQKEK
                     MYAVVAPAITGQVEANVTYGQIKNAIKSLGFVDVLEAACGADAVTVHESLEFAERMEKG
                     EAFMTNSCCPGFVGYIEKTYPNHVGKISSTVSPMIASGRFIKSHEPDAKVVFIGPCTAK
                     KSEAAKKELKGAVDYVLTFEEIMALFEAFDIDLAKCSNEDIDDASIFGRGFGAAGGLTK
                     AIENYLAEKGIGVNFEPVKISGSREIKKTMTMANLGKLEGNFIEGMMCEGGCINGSGKF
                     LSGAKVKATFDRKNSQSTKKSVLANTKIKDFSNINLEK"
     CDS             16342..17838
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_851"
                     /sec_met_domain="Fer4_7 (E-value: 5.3e-09, bitscore: 34.3,
                     seeds: 208, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 1.5e-09, bitscore: 35.1,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 0.00016, bitscore: 19.7,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFEFETQLKRLKHEVLTAVARLSIEENLTKENIEKIPYEIIKGEK
                     ARYRCCVYKEREVVLERAQLALSLTPNSKYGDINPDSVSLDTDEQIIYIVEAACDRCPI
                     NEFTVTELCRGCLAHRCKEACKFGAISYINGRAYINHDLCKACGMCKSSCQYDAISEVV
                     RPCKSVCPTGALDFNRNTMKAMIHEDNCINCGACMSACPFGAISDKSLIAPVAKKLAKK
                     ENMYAIVAPAITGQIDSNITYGQLKNAIKSLGFVDMIEASCGADAVTVHESNELIERIK
                     SGDNYMTNSCCPGFFKYIEKMFPDEKDRISSTVSPMVATGRLVKKIDSDAKVVFIGPCT
                     AKKSEATEKSLKDSVDYVLTFEELMALFEAFNIDLSKCSNEDINDGSIFGRGFGASGGL
                     AKSVQNYIAEKGLSFDFEPIKVSGPRQIKKTMTMAKLGRLEGNFIEGMMCEEGCINGAG
                     KFLSGVKAKNTFDRKNGQSTKKSVLSNDKIKEFEDVNLER"
     CDS             17972..18898
                     /locus_tag="ctg1_852"
                     /transl_table=11
                     /translation="MRKIVLKDILFLVTTLSIIVILLLVTNITTNSKIKSTSESYLKSD
                     KNSVRQNGIQRSTKSSTKNTAFKTTILNTGKSDCILVEIGNKVIMIDTGEDKNGKQIVD
                     RLKEKGINTLDYLILTHLDKDHIGGVDSVLSSVKVKNIIQANYKKDSKQYDEYIDSLKK
                     ADIEPVLLKDNMNIVINGAEINIHPASKSKYESSNDYSIITNISYGAHKFLFAGDAEEE
                     RLSEFINGNTLKYDFVKMPHHGRYDKLTETFLESISPQYAVITCSEKKEPEEGVLKILE
                     RLNIKTFLTSNGEVVINSDGKTLSVNQ"
     CDS             19016..19207
                     /locus_tag="ctg1_853"
                     /transl_table=11
                     /translation="MLDRFFGEGGFGGCAWWIIILFFLFLAFQDCWAEMDLCAWIPFLI
                     LLLILCECGDVFDGGCGC"
     CDS             19430..19780
                     /locus_tag="ctg1_854"
                     /transl_table=11
                     /translation="MAIVDKIFNEIKLMVARLLLGKKYSEYEEKDLVYNTEEEVILITL
                     KRLVFQGNVNEAEEILFDKAKSVNSENMQYIAIEFYTMLMEKTDEELEAMNFSKQEVYQ
                     GIEDIRKVLNLE"
     CDS             20041..21546
                     /locus_tag="ctg1_855"
                     /transl_table=11
                     /translation="MKVGFDHKKYLEEQSKYILERVNNFDKLYLEFGGKLMGDLHAKRV
                     LPGFDENAKIKVLQHMKEKVEVVICVYAGDIERNKIRGDFGITYDMEVLRLIDDLRGYE
                     LDVNSVVITRFEGQPATTVFINKLERRGIKVYKHYPTKGYPSDVETIVSDEGYGANEYI
                     ETTKPIVVVTAPGPNSGKLGTCLSQLYHENKRGNVVGYSKFETFPVWNVPVKHPLNIAY
                     EAATVDLKDVNMIDSFHLETYGEMSVNYNRDLELFPVLKKIIEKITGKESIFQSPTDMG
                     VNRVGFGIIDDEVIRKASIEEIIRRYFKTACEYKKGQVDKGAYDRMKMIMEELNLKPED
                     RNVVLPARNYSNKLKESADKNDTCPVVALELEDGTILTGKGSDLMNGTAAVVLNAIKHL
                     ANISDDMHLISPVILEPIINLKTKTLASRNVSLSCQEVLTALSICAVTNPTAQFAMEKL
                     ALLKGCQAHSTTILNRDDEQTFRKLGIDVTCDPEYPSQNLYYS"
     CDS             21936..23033
                     /locus_tag="ctg1_856"
                     /transl_table=11
                     /translation="MKHYRKIIHIDMDAFYASIEQRDNKKLKGRPVIVGGNPQSRGVVA
                     TCSYEARKFGIHSAMPSAVAYNRCPYAVFVRPRFDVYKSVSEQIRDIFYRYTDLVEPLS
                     LDEAYLDVTKNKKNIDSSIEIAKQIKKDIFREVGLTSSAGVSYNKFLAKIASDLRKPNG
                     LTVITEENAQDFLDKLPVNKFFGVGKVTSNTLKNLGIKTGYDLRCLNLFELENIFKKRG
                     YELYKFARGIDDRPVEPNRVRKSVGAETTLSHNLDIDEEETRNILDELCEEVCHRLKNS
                     EKFGKTLTLKIKYEDFTKITRSLSLEHYIDEYNDIRSGVDNLLRNVEVNGKQIRLLGVT
                     ISNLSDKKETYKDITLFEYMDSIQM"
ORIGIN
        1 tctatgtttt acaaccattt atgaatgaaa aagaaggaaa ttggtataat ggtacagcac
       61 atgcgatata tcaaaatatg gactttgtag atacctataa tccagaatat gtattgatat
      121 tatctggtga ccatatatac aagatggatt atagcaaaat gttaaaattt cataaggaaa
      181 aaggctctaa agctacaata gcagtgattg aagttccttg ggatgaagct tcaagatttg
      241 ggataatgaa tacaaatgaa gattcaagta tctatgaatt tgaagaaaaa ccaagtgaac
      301 ctaagagcaa tttggcatct atgggagtat acatatttga ttggaaaatg ttgagaaatt
      361 attttaagga agcagaaaaa aatccagaaa taaattatga tgattttgga aaaaatttaa
      421 tacctaaaat gttagaagat aatgttggaa tgtatgctta tccatttaaa ggatactgga
      481 gagatgtagg aactatacaa agtctatggg atgctaatat ggatataata aaatctccag
      541 aaacacttga tttagcagac cctaagtgga agatatatac aaatactatg gcaatgcctc
      601 cacaatatat aggtaaaaat gcaaatgttc atagatcaat gatagctgat ggttgtagaa
      661 ttttaggtga agtaggtaac tctgtattat cacatggagt tgttgttggt aaaggaagta
      721 aagtaattga ttcagtaata atgccaaatg ttgtaatagg tgaaaatgta actatagaaa
      781 aagctatgat aggtgagtgt gcaactataa atgataatgt tcagataaag aatgtaaata
      841 atgaaataaa tgtagtttct gagtatgaaa atatcgaacc tagatgcgta ttaatagaag
      901 gaggtcttta agatgagaaa tgaatgttta gggataataa atttaaacaa aaaaggagac
      961 ccagcaataa acaaacttaa ctatggaaga ccaatagcat ctacaccaat agctggaaga
     1021 tatagaataa tagactttgc tttatctaat atgataaatt caggaatcac taaagttgga
     1081 atattcgcaa aagaaaaata cagatcatta acagaccata taggtagtgg taaagattgg
     1141 gatttaagta gaaaaaaagg tggcctatca atttttagtc cagaaaacac taagtataga
     1201 aatacttact cacatagaga aggtgatata tatactatct tagctaatct agattatata
     1261 gaaaagagtg aagaagaata tattttaata gctccaagct atatgctatg caatttaaat
     1321 tattctcaag cattggaata ccataaaaaa tctcataatg atataactat aatatataaa
     1381 aatgtaaata atgcaaataa agattttgct ggtaacttaa ctctaaattt agatagtaac
     1441 aatagggtaa taaatgtagg aaataattta ggtaagttcc ctagagcaaa catatgtatg
     1501 gagacatata ttatgaagcg tgaagatttt gttgaatgta tatataacat tgtaaataaa
     1561 ggcaattatt gttatttaga agaatttatt attgaagaag cagaaaacat gaaaatagga
     1621 gcctatgaat atacaggata tctaaaatgt gtaaattctg ttgaatcata ttttgaaatg
     1681 agcaaagatt tattaaattt agaagttgca gatgaattat tatattctga aagaaagata
     1741 tttacaaaag aaaagaatga atcacctaca atttatacag atagtgctaa agtagaaaat
     1801 agctttatag catctggttg tttaatagaa ggtactgtaa aagatagtat catatttaga
     1861 aaggtaaatg ttgaaaaagg aacagttata gagaactcaa tagtaatgca aaattgtgta
     1921 ataaagtcaa atgcaaaact atataatgca atattagata aaaatacaag tgtatcaaat
     1981 gggaaagaat taagaggaga tgaaaaatat cctcttgtag tggaaaagaa tacaaatata
     2041 taaataaatt ttttagaagg gggaatgact aatgaaggtt ttttatgtaa cagcagagtg
     2101 ttggcccttt gcaaaaactg gaggattagg agatgtttct tatgcattgc ctaaagaatt
     2161 aaaaaaagaa ggtgtagatg taagggtaat aatgcccaaa tattcaacta taccaagtta
     2221 tttaaaagat caactaaaag aaatagctgt gtttagtgta cgtgttggat ggagaaatca
     2281 atactgtggt cttttagaaa tggaattgga tggtgtaaaa ttttacttta tagataatga
     2341 attttatttt agaagagaag atgaaagaaa gagtatctat ggatatggag atgatgcaga
     2401 aagatatact ttctttacag atgcagtttt agaagctata agtagaattg atttttatcc
     2461 agatgtaata catataaatg attggcatac agggatgtta ccattaattc taaaagaaag
     2521 atatgcaacc cttgaggggt ataaaaatat aaaaactatg tatactatac ataatctcca
     2581 atatcaaggt gtatttgata agcatgtttt atatgatata ttggacttac cacaaaaata
     2641 ctttgataat ggagatatag agtattatgg ctcaataaat tttatgaaag ctggtataaa
     2701 ttttgcagat aaaattataa ctgttagtcc tacttatgca aatgaaatac aaacatcttt
     2761 ttatggcgaa caattagatg gattacttag aaaagagtca ggaaaattaa aaggtatatt
     2821 aaatggtata gattatgatt taaatgaccc tgcaaaagat aaagatatat ttgttcatta
     2881 tgatgtagac tcaattgaca aaaaagtaga aaataaattg agattacaag atatattggg
     2941 actaaaaaaa gattcatcta ttccgttgat aggtatagtt tcgagattag tttctcaaaa
     3001 aggatttgat ttaatagcat acatgatgcc agaacttatg agagaagatt tacagattgt
     3061 cgttttagga actggagaac atcaatatca atcaatgttc aactattacg attctaattt
     3121 ttcagataaa gtatcagcta gaattacttt taatgcatca ttggctcaac agatatatgc
     3181 tgcaagtgat atgttcttaa tgccatcatt atttgagcct tgtggtatag gtcaaatgtt
     3241 agctatgaga tatggttctt taccaatagt tagagagact ggagggctta gagatacagt
     3301 aacaccttat aataaattta ctggagaagg caatggattt agttttaaaa attacaatgc
     3361 tcatgagatg tttttctgtt tgaaaaatgc aatcaaagta tttaaggaca aagaaaaatg
     3421 gattaaatta gttgaaaatg caatgaaaac agataatagt tggaaaaaat cagctaagga
     3481 gtatatagaa acatatagag acatatgtga ttaaaggagt ggtttttttg gtaacaataa
     3541 gcaaaaagaa attcaagcaa aaatttgaag taaaaatgta tagcttatat gcacaatcta
     3601 tcaaggaagc tactgatgaa caattgttaa atgtattatg tagtctattg aaagatgaga
     3661 tagcaaaaaa atgggttgct acaaagttag ataagaaaaa agaagtttat tattttagtt
     3721 tagaattttt aatagggaga cagttaaaat ctaatttatt aaatttaaat attgaagaag
     3781 aagttagaga aggtttatct gaattaggaa tcaacttgga tgatttaatt gaagctgaag
     3841 tagacccagc cttaggaaat ggtggacttg gtagattagc agcttgcttt ttagattcta
     3901 tggcatcttt gaacataagt ggtcaaggat atggaataag gtataaatat ggtctgtttg
     3961 aacaaaaatt tgtaaatggt tatcaggtag aagtgcctga taactggctt acagaaggac
     4021 gatatgcatg ggaaactgta agaccaaatg aagcaacaat ggtgaagttt ggtggtgagg
     4081 tagaattaat caaggaaggt agtcatttaa aagtaattca taaaaactac cttcctgtaa
     4141 tggcaatgcc ttatgatata ccaataatcg gataccaaaa ccaatgtata aatactttaa
     4201 gattgtttaa gagtgaaata ccaaagagag attttggtga acttacctca aatgctctaa
     4261 attattctgg tagctatgaa gaggctttaa aacataagta ttatactgag gaaatatcac
     4321 aggtattata tcctgatgat tcaaactatg caggtaagtt gttgaggttg aaacaagaat
     4381 acttttttgt aagtgcaggg atacaagata taataagaaa atataaaaag aacaaattaa
     4441 atattaataa tttattcgat aaggtagcaa ttcatataaa tgatacacat cctaccttat
     4501 gcataccaga acttatgaga gttttgcttg atgaagaaaa tttatcttgg gatgaagcat
     4561 gggaaataac taaaaaaaca gtgtcctata ctaatcatac tataatgtca gaagcaatgg
     4621 aaaaatggcc tgtaagtatg atgaaagaac tattaccaag aatttatatg ataatagaag
     4681 aaataaatag aagatatgta gaggaattaa ataataaagg atatgaccaa gatagaataa
     4741 aaagaatgag tataatagac tgtgacaata tcaatatggc aaacttatgt attgtcacaa
     4801 gtcatagtgt aaatggagtt gctaagcttc atactcatat tcttgaaaca gaggtattaa
     4861 aagatttcta tcaagatgaa ccaaataaat ttaataataa gactaatgga attgcacata
     4921 ggcgatggct tataagttca aatcctcaac ttagcaattt aattacagat ttaattggtg
     4981 attcatggaa gaaagataca ttacaattaa aaaatattga aaaatttaaa aatgattcct
     5041 ctgttttaca aagacttgat gatataaaat acaataataa agcaaatcta gcaaagttta
     5101 taaaagataa atacgattta aatgtagacc caagttcgat atttgatgtt caagttaaga
     5161 gattgcatgc gtataaaaga cagttactga atatatttaa tgtacttcat atgtatcatg
     5221 aattacttga taatcctaat ttgaatcttg acccaagaac ttttatattt ggcgcaaaag
     5281 cagcaccagg atattatttg gctaaatgta taattaaatt tataaattct gttgcaagta
     5341 ctataaataa tgatgttaga gtaaaggaca agttaaaagt agtattttta gagaattatg
     5401 gagtatcatt agcagaaata ataataccag cagcaaatgt tagtgagcaa atttcaacta
     5461 caactaagga agcatctgga acaagtaata tgaagtttat gatgaatggt gctataactt
     5521 tggctacact tgacggtgca aatgtagaga tatgtgaaca ggttggtaaa gaaaatatgt
     5581 ttttatttgg acttagtgca gaacaagtac taaattataa taaatatggt ggatattctt
     5641 cacttgacct atatcattct aatatggata taaaaagggt agtagatgat ttaataaatg
     5701 gatttattcc taatcttggc gaagaaggaa gaagtattta taattcactc actacttaca
     5761 atgatgagta ttttgtattg agagattttg aaaattatgg tcaagctcaa gcagatataa
     5821 acaggttata tagagataaa gaaaaatgga ataaaatgtc tttagttaat atagctaatt
     5881 ctggattttt ttcttctgat agaacaattt ctgagtatgc aaaagacatt tggtttaaaa
     5941 gggtgtgatt aaatgcaaag tgtaatagaa tataactctt gggataaaaa ttttaaggct
     6001 ccgtttggag ctttaaaatt tgatgaggaa ttgaccattt gtgttaaagt aaatgaggga
     6061 tacaatatca agtctatttc cctagaaata aatagagaag aagaaatgag aacaataact
     6121 ttaaatgaag aattagataa tgataaactt ggaaagtgct tttgtggtaa gattgaaaag
     6181 tttgatggta caggtgttta tttttattac tttaaagttg atgttgaaat ggatggtcag
     6241 ataaagactt tattttatgg aaaaaacaga gataatggat attcttgtga atataattat
     6301 agtgatatta ataaatatca aatcactgtt tacaaagatt ttaaagtacc aacatggtac
     6361 aaagaaggaa tactttatca tatatttgta gatagattca ataatggaaa tcgtagtggt
     6421 aaggttgata atcctaaaaa aaatagtttc atatatggaa attgggaaga tacacctatg
     6481 tacataaagg atagtcaagg ggatgttata agatgggatt tccatggtgg aaatttaaga
     6541 gggataatca ataaacttgg atatttaaaa aaattaggtg taagtatact atatctaagc
     6601 cctatatttg aagcctctag taatcataag tatgatacag gtgactataa aaaaattgac
     6661 ccaatgtttg gggatgaaga tacatttaaa gaacttattg ataaagcaaa agaaaaaggt
     6721 atatcaatag tattagatgg agtttttagt catactggag cagatagtaa atattttaat
     6781 atgtatggaa actataatag tttaggggca tatcaatcta aagaatctcc atattattca
     6841 tggtatatgt ttgaagaatt tcctcaaaaa tataaaagtt ggtgggatgt taagacattg
     6901 ccaaatataa atgaattaga acatagctat atggattata taatatatga caatgatagc
     6961 gttataaata aatgggtaaa tatgggtatt aagggctgga gactagatgt tgcagacgaa
     7021 ttaccaacta agtttataag agagttaaaa aaggaattaa aaaaggcaga tgatgactca
     7081 attcttatag gtgaagtatg ggaagatgca tcaaataaga ttagctatgg tcagagaaga
     7141 agttatttat taggtgaaga attagattct gttatgggtt atccttttag aaataacatg
     7201 ttttctttct taaaaggaga aattaattca tatgaacttt gtaatagata tatgcagatt
     7261 aaagaaaatt atccaaaaga atcatttagg tctaatttaa atttaattgg aacacatgat
     7321 gttacaagag ctaaaacgga attaaatgat gatgtagatt tagtgaagct tgctgtagct
     7381 atacagatga catttgaagg agtaccatat atatattatg gagatgaagc aggtctttgt
     7441 ggaggtgttg acccagataa tagaagaact tatccatgga aaaatgaaga cgaagatatg
     7501 cttaattttt atagagatgt tataagaatt agaaataaga ataaactttt aagttctgga
     7561 aatacagaat ttatatatac taataatgat tctgtatttt cttttattag agttaatgaa
     7621 aataatgata gaatgttaat tttagtaaat agaagtgaaa atgtggaaag tatatcatta
     7681 tgtatagaga gtagttttat tgaggaaata cctataaagt atagtcttaa aaatgcaaat
     7741 agtactatac aaattgaaaa taatgagttg aaagtagatt tagactctaa atcatttaga
     7801 atttttagag taaattaaat atcttttttt agaaaaataa atagaaaata aggtgaatgt
     7861 ggaaagagtt ttgttttatc aaaacttttt ctactttttt tgtataaatt atcataagaa
     7921 ttttagtatt tcaaaatatt acaaagaagt ataaaaaata tcataattgt gatattatat
     7981 aaattagtaa gataaaactg aactctctac caaagttgta gggagattta acttttataa
     8041 tcttaatatg gaggaacgtc ttatgaaggt agatccactt acaactcaag tatatgacta
     8101 tatatcaaag aaaatccaaa atggagaata tgaagctaat cagagaatta ctgaatctga
     8161 gatttgtaaa tctatcggag ttagtagaac accagcgaga gaagcattaa ctaggttagc
     8221 aggtgaaaat ttactagaaa aaatacctaa taagggattt gtagtaaaag aatttcagga
     8281 aaaggagaaa ttagacacct attccgtaat tggagtattg gatgcgttag ccggttcttc
     8341 agcattacaa aatttaactg aatcagacct agtaaaaatg gaagaattaa cagaaatgat
     8401 ggcggtctct ataaagtata aaaattacaa tagctattta aaattaagta atgaatttca
     8461 cgatatatac ataactaaat cagataatca ggtgttagta aatctattga actctttaag
     8521 atataatttt atgtcaaagt catatactag tgataatgaa gatgagttat ataaaatgtt
     8581 gacatacagc aataatcaac atattgaagt agtaaaatct atgagggaga atgatttaga
     8641 aaatgttgaa agaattttga gagaacattg gaaaacgata cctatggaag agatgaaaaa
     8701 agagaagctt ttataaagtt tctctttatt ttttatacca ttttatcact atttttttga
     8761 attattaagt agaaaataat aattaattta aacttgagga ggaaaactaa tatgtatcca
     8821 aataaagaaa ttgcaataga agagttagaa gtggctggca aaatgaatcc cggtccatgg
     8881 ataaaacatt cttacaatgt tgctaatgta gctaaattga ttgcagagca atgtgaaaat
     8941 ttgaatagtg aaaaggcctt tgtatgtgga ttattacatg acattggaag aagaactggt
     9001 atttcttctg taaggcatat tattgatgga tatgattatg ttatttctaa gggatgggat
     9061 gaagtggcga gggtatgttt gacacattct tttcctgtta aggatataga agctgatatt
     9121 ggaaataaag atattagtaa agaacagtat gattttatca atcactattt aaacaacctt
     9181 gaatataacg attatgataa gttgattatt ctttgtgatg cattagcaga tgcaaatggg
     9241 ttttgtattt tagaaaaaag atttgttgat acaacacgaa gatatggaat atatccattt
     9301 tcagttgaac gatggaataa gacttatgag tataaagaat atttcgagaa aataatcaac
     9361 aagtctatat atacattgtt acccaatatt gaaaaatcta tatattatta aatcctaagt
     9421 taataattta atatccagta tcaccagcag ttggtcatta tgattgactg cttttattat
     9481 gcttatatta aaaaaataca ctatggtttg tgtatatcaa agttatatgg aatgaaaaga
     9541 gaatttattt tatcaattaa aaaatttaat aaattttata ttaaaattaa aatacaaaaa
     9601 taggaaaatt atttagtcca actaaaccaa gaattttgat atgtgaaata agaataatat
     9661 aaaagtttag taataaaata cttataaatt aaaaatagta aactcaaaag cttactaaaa
     9721 ctcaaaaaag taaaaaaaac aaaataataa aaaataagaa agtttataaa tactaagttt
     9781 taaaaaaatt aatataaaca acaaaaaaat aaaaagttta taaatattga tatagctaat
     9841 gtatatgttt ttgagtaact tcaaaaaaac acttgtaaaa atgctgagat gttaatataa
     9901 taaatatcat gagtttaata aaagtaaaaa taaaaaatag aaataataaa taataaatat
     9961 taaaaatatt tgaatataga gaggagatga atttgaaatc atggatagcg agtttgcaaa
    10021 tgcagttgaa ttaagctatg agtgtgctcc attattagag tcgttaaagg aatactcaga
    10081 gaaagatata gcttgttttg atgtgcctgg acatgtaaaa aatagaggtg tagctatatt
    10141 aaataaatat ctaggtgaaa gtctcatgaa aatggatata aattcatcac caactatgga
    10201 taatgtatct gcgccaaatg ggattataaa aaatgcacaa gatttgctag cacaagcata
    10261 tatggctgat gaggcattct ttataacgaa tggcacaact caagcaatac atgcaatgat
    10321 tttgagtgtt ataaaaccag gtgaaaaagt attacttcca agaaatatac ataaatcagt
    10381 aataaatgcg ttaatacttt gtggaggaat accaatattt atacaaccag aatttgatga
    10441 aaaactaggt ataagtttaa atattactct tgaaaaagtt agaacagaga tagaaaaaga
    10501 ttgtaatata aaagcattat ttttccttaa tccaacttac tatggagttt gtgcagacct
    10561 tgagagtatt atagaactat gccataaaaa taatgtttta gtgttagttg atgaagctca
    10621 tggtgcacat tttccatttc atttagattt acctccttct gcaataagtt tgggagctga
    10681 tatggtagct gtaagtatac ataaaactgg aggagcattg acacaatctt cagcactctt
    10741 attgaataga gataatgtaa gttttgaaaa ggttcttcaa tcaatcaata tgctacaatc
    10801 aacatcagca tcttatttgc ttatggcaag tatagatggt gctagagtta atctagttga
    10861 gaatggtgaa aagcaactgt caaaagcatt aaatctatct aggtatgcaa aatctaaatt
    10921 aaacaaaatt gatggaataa aagttttatc tacagaaata ttgaaacaaa aaggtgttaa
    10981 atttatagat gaaacaaaat tgtgtataaa tgtaaaagaa ttaaatttga ctggatttga
    11041 agtatacgat ttattatata aaaatttttc aattcaagta gaattgggag attcatataa
    11101 tatactggca cttgtgtcca ttggaacaaa taaatcagat atagatagat tagtaaaagc
    11161 actttctata attgcaaaga tttatagaaa agaatcaaca ttaaatgaat ttaatatggt
    11221 tcaaataaat ccaattatta aacttaatcc aagagaagct ttttatgcac caaaggaaag
    11281 tgtagaaatc aattcatgta tagatagaat ttgtggagaa tcaataatgg catatccacc
    11341 aggtataccg attattgctc caggagaatt gataacagaa gaaattatgg agtatattat
    11401 tttcttaaaa aatagcaatg catatcttac agatgtacaa gataaaaact tagatagaat
    11461 attagtaata aaataaatta ctttattttg caagggcaag tatttgttaa gtagagttta
    11521 tcaaatagaa cttattaaaa gtataaagga gttggggttg aaatgaaatt tgaaacacta
    11581 ggaagacata tactagtaga atactataat tgtgatgaaa acgtacttaa agacccacgt
    11641 cttatagaaa attttatgaa tgattcagca ttaaatgcaa aagcgacaat tgtggattct
    11701 gtattccacc attttaatcc ttggggggtt tcaggagctg ttataattgc tgaatctcat
    11761 ttgacaatac atacatggcc tgaatatggc tatgcagcag cagatttttt tacttgtggt
    11821 gatatagacc catggaaaag ttttgaatta ttagagcaac ttttaaagtc tgaaagaagc
    11881 gagtctacag aaattccaag aggcttaact acaaaaatta aaaaatattc aaaaaaagat
    11941 ttaggtaaga ttactcataa accagaagca gtataaaaca tacaagagaa agtgaggatt
    12001 attatatgga actttggtat acagaagaat ggacagaaaa tgtaagattt tctataaaag
    12061 taaataaaca tctatttgaa ggaaagtctc aatttcaaag gatagatgtg tttgatagtg
    12121 atgaatttgg aaaatttcta acaatagatg gattaatgat ggtaacatat aaagatgaat
    12181 ttatatacca tgagatgata actcatgttc ctatggctac aaatttaaac ataaagaaag
    12241 tattagtcat aggtggaggt gatggaggta cagtaagaga attaagccgt tatcctcaaa
    12301 tagaaaagat tgacatggtt gaaatagata aaatggttgt agatgtatct aaggagtata
    12361 tggatatatg ctcatgtaaa ttagatgata aaagagtgag tttatatttt gaagatggtg
    12421 ttaattttgt taagtgtgca catgataaat catatgacct gataatagta gattcaactg
    12481 acccaatagg accaggtgaa gggcttttct caactgattt ttataaggat tgttatagaa
    12541 tactgactga tgatggaatt ttagtaaatc aaagtgaaag tccgtatttt gactttaatg
    12601 ctaaagagat gaaaagagct aataaaaaat taaaacagat atttccaata tcagaagttt
    12661 atcaagcaca tataccaaca tatccatctg gtcactggtt gtttggattt gcttcaaaaa
    12721 aacttaatcc agtaaaaaat caagatagaa atggatggga gaaattaagt ttaaaaacta
    12781 aatattataa tagtgatata catttaggtt cgtttatgtt acctcaatac gtgaaggaga
    12841 tgctagatga agaataattt ctatcatatg aacactttta tgagtatgga caaaaattat
    12901 gaagaatcta atcttatagt atttggtgtt ggatttgatg gaactacttc taacagacct
    12961 ggggctagat ttgcaagtag ctctatgaga aaagaatttt acggtcttga gacatatagt
    13021 ccttttttag atttggattt agaggattat aatatatgtg attatggaga tttagaaatt
    13081 agtgttggaa gtacagaaca agtcttaaaa gaaatctatc aagagacata taagattgtt
    13141 agagattcaa aggtaccctt tatgattgga ggagagcatt tagttacatt accagccttt
    13201 aaagcagtac atgaaaagta caatgatata tatgtaattc attttgatgc ccatactgat
    13261 ttgagggaag aatataataa tagtaaaaat tctcatgcaa cagtaattaa aagaatatgg
    13321 gatattgtag gtgataataa aatatttcaa tttggtataa ggtctgggac aaaagaagaa
    13381 tttaaatttg ctacagaaga aaaacacaca tacatggaaa taggaggaat agatacgttt
    13441 gaaaatatag ttaatatgct aaatggaaag aatatttatc taactataga tttagatgta
    13501 ttggatgcat ctgtgtttcc aggaacaggt acaccagaac ctggtggtgt aaattataga
    13561 gagtttcaag agatttttaa gattataaaa aactctaata taaatatagt tggttgtgac
    13621 attgtagagt taagccctga ttacgataca acaggtgtat cgacagttat agcttgtaaa
    13681 atcttaagag agttatgctt aataatatct gataaaatta aatagagtat tttatataaa
    13741 tagtatatat tataatataa gaagttattt taaaaaagtt agtttaagtt tgacgctttt
    13801 ctaaagtaac ttcttatttt tgtaattaaa aataaatata ataaacaaca aaaaagagcc
    13861 ctcgatagct ccttttctaa aatatatata tttaaattaa ataattatat tctatttacg
    13921 ttttcagctt gaggtcctct attaccttga gttatatcaa agctaacctt ttcgccttct
    13981 tctaaagttt tgtatccatc attttgtata gctgagaaat gtacgaaaac atcatcttct
    14041 ccctctacag atatgaaccc aaatcctttt tcattgttaa accattttac tattccgttt
    14101 ttcattataa gaaaacctcc gcattattaa aaaatacaaa ctaaaaaaat aagtctgttc
    14161 tattaatata acataaattt taaataaaag caaataaaat ttttaaaaaa attaattact
    14221 tttagaattt aataaaaatt gttaaattat acagtgagaa gtattgtaaa atttgacgaa
    14281 aatgtaaatg tagataataa atttaatatc aaaaaatgta acaaaaaggt atgtaagtaa
    14341 aaagtaaaat taaaatatat aataaaaaat attatatatt agattgaaaa gtaaaaataa
    14401 aaatagtgaa atttcagaaa tatcaataat attatataat aaaacaaaaa aacactatat
    14461 atattcgata aaataaaatt taaacatata atattttatg tatatattaa taaaaggaca
    14521 tattgtgtta taatggtatc gtataaaatc atttacgggg gtggtattaa aatgtttcaa
    14581 tttgaaacac aaatacacaa attaagacat gatgttttaa ctgcaatagc tagacttgga
    14641 aaagaagata accttaccag agaagcaatg gataatattc agtatgaaat aataaaaggt
    14701 gagaaaccta catacagatg ttgtgtttat aaagaaagag ctataatatc tgagagagta
    14761 aatgtaagta tggggttaca accaggtcaa gataagatag atttagatac aatggatata
    14821 gaagaagatg aacaaattat atatattttg gaagctgcat gtgacagttg tccaataaat
    14881 gaatttacag taacagatat ttgtagagga tgtctagcac atagatgtaa agaagcttgt
    14941 aaatttggag ctataacaca tgtcggagga atggcctata taaatcatga attatgtaag
    15001 gcttgtggaa tgtgtaaaaa agcttgtcaa tatgatgcca tctcagaggt tgttagacca
    15061 tgtaagagtg tttgtccaac taatgcctta ggatttgata gagaaaatat gaaagctatg
    15121 atacatgagg ataaatgttt aaactgtgga gcatgtatgt cagcatgtcc atttggagca
    15181 atatctgata agagtttgat agctcctgta gctagaaagt tagttcaaaa agagaaaatg
    15241 tatgcggtgg tagctccagc tataacaggt caagttgaag caaatgttac atatggtcaa
    15301 ataaaaaatg ctataaaatc actaggattt gttgatgtat tagaagcagc ttgtggagca
    15361 gatgcagtta cagttcatga aagcttagaa tttgctgaaa gaatggaaaa gggagaagct
    15421 tttatgacaa attcttgttg tccaggattt gttggttata tagaaaaaac atacccaaat
    15481 catgtaggga aaatatcttc tacagtatct cctatgatag ctagtggtag atttataaaa
    15541 agtcatgaac cagatgctaa agttgtattc ataggaccat gtacagccaa aaagagtgag
    15601 gcagctaaga aagaattaaa aggagctgtt gattatgtac ttacttttga agaaataatg
    15661 gcattatttg aggcatttga tatagacttg gctaagtgtt caaatgaaga tatagatgat
    15721 gcatcaattt ttggaagagg ttttggagct gctggtggtc ttacaaaagc tatagaaaat
    15781 tatcttgctg aaaaaggtat tggtgttaat tttgaacctg taaagatttc tggttcaaga
    15841 gaaatcaaga aaactatgac tatggctaat ttaggaaagc tagaaggtaa ttttatagaa
    15901 ggaatgatgt gtgaaggtgg ttgtataaat ggttctggta aattcttatc aggtgcaaag
    15961 gttaaagcca cttttgatag aaaaaattct caatcaacta agaaaagtgt cttagcaaat
    16021 acaaagataa aagattttag taatataaat ttagaaaaat aaagataata caaagcaaca
    16081 aaaatacata ttgttaatag agttgttcta agttgaggtt taacttttgg acaactctat
    16141 ttttatttat atatttaatt attgaacaac taaaataaaa attatataca cttaaaataa
    16201 aaattacata tataatattt tgtatataac ttaacaaagt atatgcctat gttataataa
    16261 tttatagaaa taaataaaaa atacaatata cataatagta gaaatatagc aaaaaggtgt
    16321 gatttatagg gaggattact tatgtttgaa tttgaaacgc aactaaaaag gttaaaacat
    16381 gaagttttaa cagcagtagc aagactatct attgaagaaa atttaacaaa agaaaatata
    16441 gaaaaaattc catatgaaat aattaaagga gaaaaggcga gatatagatg ttgtgtttat
    16501 aaagagagag aagtagttct tgaaagggcg caacttgcat taagtttaac tccaaatagt
    16561 aaatatggag atataaatcc agattcagtt agtttggaca cagatgagca aattatatat
    16621 atagttgaag cagcatgtga tagatgtcca ataaatgaat ttacagttac agagctttgt
    16681 agagggtgtt tggctcatag atgtaaggaa gcatgtaaat ttggggcaat ttcttatata
    16741 aatgggagag catatataaa tcatgattta tgtaaggctt gtggaatgtg caaaagttca
    16801 tgtcaatatg atgctatatc agaagttgta agaccttgta aaagcgtttg tccaacagga
    16861 gctttggatt ttaatagaaa cactatgaaa gcaatgatac atgaagataa ttgtataaat
    16921 tgtggagcat gtatgtcagc atgtcctttt ggagcaatat ctgataagag tttgatagca
    16981 cctgttgcaa aaaaacttgc aaagaaagaa aatatgtatg caatagtagc tccagctata
    17041 acaggtcaaa tagatagtaa tattacatat ggtcagttaa aaaatgctat aaaatcactg
    17101 ggatttgtag atatgataga agcttcttgt ggagcagatg cagttacagt tcatgaaagc
    17161 aatgaactta ttgaaagaat aaaatcagga gataattaca tgacaaattc atgttgtccg
    17221 ggatttttta agtatataga gaagatgttc ccagatgaaa aagatagaat atcatctaca
    17281 gtgtctccta tggtagcaac aggaagatta gtaaaaaaaa tagattctga tgctaaagtt
    17341 gtatttatag gtccatgtac agctaaaaag agtgaggcaa cagagaaaag tttaaaagat
    17401 tcagtagatt atgtacttac ttttgaagaa ctaatggcat tatttgaagc atttaatata
    17461 gatttatcaa aatgttcaaa tgaagatata aatgatggtt cgatttttgg aaggggattt
    17521 ggagcatctg gtggacttgc caaatcagta cagaactata ttgctgaaaa ggggcttagt
    17581 tttgattttg aacctataaa agtatctggt ccaagacaaa ttaaaaagac aatgacaatg
    17641 gctaaattgg gaagattaga aggtaatttt atagaaggaa tgatgtgtga agaaggttgt
    17701 attaatggag ccggtaagtt tttatcaggt gtaaaagcca aaaatacttt tgatagaaaa
    17761 aatggacaat ctactaaaaa gagtgtttta tctaatgata agattaaaga atttgaagat
    17821 gtaaatttag aaagataatt gttttggtac agtcattttt ttattatgcc acaaatatgc
    17881 ctaaaatttg ccctttttat atgtgtattt tacagagtta aggttgctat actataaata
    17941 tgtaataaat aaaatttata ggagcttttg gatgaggaaa atagtattaa aagatatcct
    18001 gtttttagtt actacattat ctataatagt aatattattg cttgtaacaa atataactac
    18061 taatagtaag ataaaatcaa caagtgaatc ttatttaaaa agtgacaaaa atagtgtgag
    18121 gcaaaatggt atccagagga gcacaaagag tagcacaaaa aatactgcat ttaagactac
    18181 tatactaaac actggaaagt ctgattgcat attggttgag ataggtaaca aagtcataat
    18241 gattgataca ggagaagata aaaatggaaa acaaatagtg gataggttaa aagaaaaagg
    18301 aataaataca cttgactatt tgattttaac tcatttagat aaggaccata taggtggagt
    18361 agatagtgtg ttatctagtg ttaaagtaaa gaatattata caagcaaatt ataagaaaga
    18421 tagtaagcaa tatgatgaat atattgactc acttaaaaaa gctgatatag aaccagtgct
    18481 actaaaagat aatatgaata ttgtaatcaa tggtgcagaa ataaacatac atccggcttc
    18541 aaaaagcaag tacgagagtt caaatgatta ttcaataatc actaatataa gctatggagc
    18601 acataagttt ttatttgcag gagatgcaga ggaagaaaga ttgtcagagt ttataaatgg
    18661 aaatacttta aaatatgatt ttgttaaaat gcctcatcat ggaagatatg acaaattaac
    18721 tgaaacattt ttagagtcta tttcacctca atatgctgtt attacatgtt cagagaaaaa
    18781 agaaccagag gaaggtgttt taaaaatatt ggaaagattg aatataaaaa catttttgac
    18841 ttctaatgga gaggtagtta tcaatagtga tggtaagaca ttgagtgtga atcaataatt
    18901 tttttaaaaa tatctaaaaa aatttaaaaa aatcattagc aaatattacc ccttaaacat
    18961 agtatatttt aggagctgaa actccacata caaaatgact aggaggtaac atattatgtt
    19021 ggatagattt tttggtgaag gcggatttgg tggatgtgct tggtggataa taatattatt
    19081 cttcttattc ttagcattcc aagattgttg ggctgaaatg gacttatgtg catggatacc
    19141 tttcttaata ttattattaa tactttgtga atgtggtgac gtttttgatg gaggatgtgg
    19201 atgctaaaaa aatcaattta gatgatttaa taaagcttat ggtgggtata aataaaatac
    19261 caaaccaatc acaatctagt gtttgaaggt agtcggaaat cccccgctac cttctttttt
    19321 ttattgttaa aatttatttt tgaattattt catttacata taataatttt tacgataaag
    19381 tctgatataa ttaaaaagaa aataaaattt atttatagga gatgtaaaaa tggctatagt
    19441 ggataagatt ttcaatgaga taaaacttat ggttgcaaga cttttattgg gaaaaaaata
    19501 cagtgaatat gaagaaaaag atttagtgta taatacagaa gaagaagtta tacttataac
    19561 tttaaaaaga ttagtttttc agggaaatgt aaacgaagca gaagaaattt tatttgataa
    19621 agctaagagt gtaaatagtg aaaatatgca gtatatagca atagaatttt atactatgct
    19681 tatggaaaag actgatgaag aattagaagc tatgaatttt tctaaacaag aagtttatca
    19741 aggtatagaa gatattagaa aagtattgaa tttagaataa aagatatatg aaaatattga
    19801 aataaattaa tgctaaggtg agaatattat acttatatat aaaaatatag tattcttatt
    19861 ttattagtta tataggtata tcttatttac cataaaacta tcttgaaaaa aattaatctt
    19921 aattgtataa tattactttg agtgaaaaag tattaacatt tttttataag atgttttact
    19981 aaaaaaatat atataaatat actgttatca acaagaaatt taatttagtg aggtgttaag
    20041 atgaaagtag gatttgacca caaaaaatat ttagaagagc agtctaaata tatcttagaa
    20101 agagtaaata attttgacaa actttattta gagtttggag gaaaattgat gggagacctt
    20161 catgcaaaaa gagtacttcc aggatttgat gaaaatgcaa agataaaagt attacaacat
    20221 atgaaagaaa aagttgaagt tgtaatttgt gtctatgcag gagatataga aagaaacaaa
    20281 ataagaggag actttggtat cacttatgat atggaagttt taagattaat agatgattta
    20341 agaggttatg aactagatgt aaatagtgta gtaattacta gatttgaagg acaacctgct
    20401 acaactgtat ttataaataa attagaacgt agaggaatta aagtttataa gcattatcca
    20461 acaaagggat atccgtcaga tgttgagact atagttagtg atgagggata tggagcaaat
    20521 gaatatatag aaactacaaa gccaatagta gtagtcacag caccaggacc taatagtgga
    20581 aaacttggta cttgtctaag tcagttgtat catgaaaata aaagaggtaa tgtagttgga
    20641 tattctaagt ttgagacatt cccagtttgg aatgtacctg taaaacatcc tttgaatata
    20701 gcttatgaag cagctacagt tgatttaaaa gatgtgaata tgatagattc attccacctt
    20761 gaaacgtatg gtgaaatgtc agtaaactac aatagagatt tggaattatt tccagtgctt
    20821 aaaaaaataa tagaaaagat aactggaaaa gaatcaattt tccaatctcc aactgatatg
    20881 ggtgttaata gagttggctt tggaataata gatgatgaag taataagaaa agcttctata
    20941 gaagaaataa taagaagata ctttaaaact gcctgtgagt ataaaaaggg acaagttgat
    21001 aaaggtgctt atgatagaat gaaaatgatt atggaagagc ttaacttaaa gccagaagat
    21061 agaaatgttg tattacctgc tagaaactac agtaataaat tgaaagaaag tgccgacaag
    21121 aatgatactt gtcctgtagt tgcattagaa ttagaagatg gtacaatatt aactggtaag
    21181 ggttctgatt taatgaatgg aactgcagca gtagtattaa atgccattaa acatttagcc
    21241 aatatatctg atgatatgca cttaatatca cctgtaatat tagaacctat cataaactta
    21301 aaaacaaaga ctttagctag tagaaatgtt tcacttagtt gccaagaggt gttaactgca
    21361 cttagtattt gtgctgtaac taatccaact gcacaatttg ctatggaaaa gttagcatta
    21421 ttaaaagggt gtcaagctca ttctactact atattaaata gagatgatga acaaacattt
    21481 agaaaacttg gtatagatgt aacttgtgac ccagaatatc cttcacaaaa tctttactat
    21541 agttaaaatt atataaaaaa atatgggctg ttttaaagta atagtttgag cagtccatta
    21601 caattataat aaaatcagta ggctgtcttg tataagacag tcttttgttt ttaaaacatc
    21661 ccataaatta aatatatata ctgttatcca taaggaattt taaatttagt tccttggaat
    21721 acctattgta aagcttttat atagtttttg caagtgtttt taaggatttt ttataaatta
    21781 tattgaagtt aatggattat agatggtttt atttatggaa aatatgaata tataaagaaa
    21841 ataatgaaaa aataccaaaa agaaacataa gtttggtata attaaaaagt aatataaata
    21901 aaattaatct atttatactt taaaaggtga taataatgaa acattataga aaaataattc
    21961 atatagatat ggacgctttt tatgcatcta tagaacaaag agataataaa aaattaaaag
    22021 gaagacctgt tattgtcggt ggaaatccac aaagccgagg tgtggttgca acctgttctt
    22081 atgaagctag aaaatttggt atccattcag ctatgccatc agctgtagct tacaataggt
    22141 gtccatatgc agtttttgta agacctagat ttgatgttta taagagtgtg tcagagcaaa
    22201 taagagatat attttataga tacacagatt tagttgaacc attatcttta gatgaagctt
    22261 acttagatgt aacaaaaaat aaaaaaaata ttgattcatc aattgagata gcaaagcaaa
    22321 taaaaaaaga tatatttaga gaagttggtc ttacttcttc agctggtgtg tcatacaata
    22381 agtttcttgc taagattgca tcagacttaa gaaagccaaa tgggttaact gtaataaccg
    22441 aagaaaatgc ccaggacttt ttagataaat tacctgtgaa taaatttttt ggtgttggaa
    22501 aagttacttc aaatactctt aaaaatttag gtataaaaac tggatatgat ttaaggtgtt
    22561 taaatttatt tgaacttgaa aatatattca aaaaaagagg ttatgaatta tataaatttg
    22621 ctagaggaat agacgataga ccagtggaac caaatagggt tagaaaatct gttggggctg
    22681 agactacatt aagtcataat ttggatattg atgaagaaga aacacgcaac attcttgatg
    22741 aactttgtga agaagtatgt catagattaa aaaactctga gaagtttgga aaaacattaa
    22801 cattaaaaat taaatatgag gactttacaa agataactag aagccttagt ttagaacact
    22861 atattgacga atataatgat ataagaagtg gtgtagataa tttgttgaga aatgttgagg
    22921 ttaatggaaa acaaattagg ctattgggag ttacaatatc aaacctaagt gataaaaaag
    22981 aaacttataa agatattaca ttatttgaat acatggatag tatccaaatg tgagttttgt
    23041 ttaaatgaaa taacactagc tttaatacta tataattgag gctagtgtta ttttatgaat
    23101 atttttatat tttttgtttt ttgacattgt atattatata ctatatataa atactttata
    23161 tttgtagcaa tattcagaca aatagtgacc taaaaatcgt actttgttta cataaataaa
    23221 atagtatgat ataattataa aaacaactta taatattgga gaaggttgct tgttcgaaaa
    23281 aggggatgat aaattatgat agagataaga aatgtaacaa aaaaaatagg aaataatgtt
    23341 atattagatg atatttctct agttgtagaa acaggtacat tggtagtttt gattggttca
    23401 agtggttgtg gaaagactac tactttgaag cttataaaca aattaataaa acctacatct
    23461 ggtgagatat atattaatgg caaaccaatt tctcaggaaa atgaaataga gcttagaaga
    23521 aaaataggat atgttataca gaacacaggc ctattccctc atcttacaat aaaagaaaat
    23581 atagagctaa ttccacgcct aaaaaaggaa aaatccgttg aagaaattga aaaaagaacg
    23641 ttgcaactac ttgagatggt aggacttgat agtgatgaat ttttgaataa gtatccttca
    23701 gaacttagtg gtggacagca acaaa
//
