LOCUS       c00176_NZ_CBVI..       14089 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CBVI010000176.1 Bacteroides timonensis isolate AP1, whole genome
            shotgun sequence.
ACCESSION   NZ_CBVI010000176
VERSION     NZ_CBVI010000176
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-03-14 01:32:33
            Original ID  :: NZ_CBVI010000176.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14089
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14089
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1133:4089]"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1134..4089
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
     cand_cluster    1..14089
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /kind="single"
                     /product="Pyruvate2acetate-formate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14089
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Pyruvate2acetate-formate"
                     /region_number="1"
                     /rules="((PFL_acetate1 or PFL_acetate2) and Radical_SAM)"
                     /tool="gutsmash"
     CDS             complement(443..880)
                     /locus_tag="ctg176_1"
                     /transl_table=11
                     /translation="METFDYSQVPYGFGLCASADCPKTSTCLRHIALEHAPVKYPFLPT
                     LTPQKLQAMKGKCEYYRSNKPVRYAKGFTQLLNSLTVSVSGTFRWRLISHLGRRNYYLA
                     RKGDWLIKPADQQYIIRLAKECGLQLDDYFDDYVDGYNWGD"
     CDS             1134..3362
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: PFL_acetate1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Gly_radical"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg176_2"
                     /sec_met_domain="Gly_radical (E-value: 2.2e-46, bitscore:
                     146.8, seeds: 99, tool: rule-based-clusters)"
                     /sec_met_domain="PFL_acetate1 (E-value: 0.0, bitscore:
                     1160.8, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELNKTFIDGLWSKEINVSDFVSKNIAPYTGDASFLQGPTERTKH
                     IWELCLKALEEERANNGVRSLDPHTVSTITSHQAGYIDKENELIVGLQTDELLKRAIKP
                     FGGINVVAKACRENGVEIDDKVKDIFTHYRKTHNDGVFDVYTEEIRSFRSLGFLTGLPD
                     NYARGRIIGDYRRLALYGIDRLIEAKMEDLHNLTGPMTDARIRLREEVAEQIKALKDIK
                     IMGEYYGLDLSRPATSAQEAVQWVYMAYLAAVKEQDGAAMSLGNVSSFLDIFIEYDLAH
                     GKINETFVQELIDQFVIKLRMVRHLRMQSYNDIFAGDPTWVTEAIGGRFNDGRVKVTKT
                     SFRFLQTLYNLGPSPEPNLTILWGPELPEGFKEFCAQVSVDTSSIQYENDNLMREVRNC
                     DDYGIACCVSYQAIGKQIQFFGARANLAKALLLAINGGRCENTGTVMVKGIPVLTGETL
                     KFEEVMSNYKKVLTEIARVYNEAMNIIHFMHDKYYYEKAQMAFIDTNPRINLAYGVAGL
                     SIAIDSLSAIKNAKVTARRNDIGLTEGFDIDGTFPCFGNNDDRVDHLGVDLVYYFSEEL
                     KKLPVYKNARPTLSLLTITSNVMYGKKTGATPDGRAKGVAFAPGANPMHGRDKNGAIAS
                     LSSVAKLRYRDSQDGISNTFSIVPKSLGPTPEDRVENLVTMMDGYFTKGAHHLNVNVLN
                     REMLEDAMEHPEKYPQLTIRVSGYAVNFVKLSREHQLEVISRSFHERM"
     CDS             3364..4089
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: Radical_SAM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1015:4Fe-4S single cluster domain (Score: 73.9;
                     E-value: 5.3e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg176_3"
                     /sec_met_domain="Radical_SAM (E-value: 3.9e-31, bitscore:
                     98.6, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINVHSYESMGTFDGPGLRLVVFLQGCPFRCLYCANPDTIDAKGG
                     TPTPPEEILQMAISQKVFFGKKGGITFSGGEPTLQAEALIPLFKDLKANGIHICLDTNG
                     GIWNEKVEELLSLTDLVLLDLKEFNPERHKRLTGCNNAKTLHTAAWLEEQNRPFWLRYV
                     LVPGYSDFEEDIRSLGEHLGQYKNIQRIEILPYHRLGVHKYEAMGWDYQLKEVKENTPE
                     QLERTEKLFKEYFETVIVN"
     CDS             complement(4133..5440)
                     /locus_tag="ctg176_4"
                     /transl_table=11
                     /translation="MMKDDELWLKKIKERLDDYSEPLPDTGWERLEKVLPVSAPMSVGK
                     KKQIMFRRWAMTAAAVVLVAVSSVSLWLLQSPVVDEVRRAAEPVLATIPDVLPEQTKPD
                     TQGEQPEPVIRRVIEQGDSRHQALVAQHLETESNVQEVNVNRQEEIVNSDLNSNVTEET
                     GKTEQAKETETSSSIPEKEEREVYRPSSRDKLHLPTEKKSSTGNKGWAVGMSVGNTGAL
                     ASLDNTNGGMHSGPNSTPMFSDKLDLPNVSSGILDIPEGQELVFEGGVPYLRKNTRQVK
                     NIKHKQPLSFGLSVRKALPKNFSVETGVTYTMLSSEITYENSSEKTDQKLHYIGIPVRA
                     NWSFVNDKRFTVYVSAGGAIEKCVYGKVGSEKETVKPVQLSVMGAVGAQYNISNRVGIY
                     VEPGVSYFFDDGSPIETIRKENPMNFTLQAGIRLTY"
     CDS             complement(5456..6004)
                     /locus_tag="ctg176_5"
                     /transl_table=11
                     /translation="MEEQELAGRCRQGDNLARKELYERYAGRMLSVCLRYAGDRDTAED
                     LMHDGFLKLFDSFDKFTWRGDGSLRAWMERVMVNTALQYLRKNDVINQSEGLDNIPETY
                     EEPDASTVETIPQKVLMQFISELPAGYRTVFNLYIFEEKSHKEIAQMLGINEKSSASQL
                     TRAKATLATKVREWMKNNV"
     CDS             6181..6879
                     /locus_tag="ctg176_6"
                     /transl_table=11
                     /translation="MKKLRFYSVVFTLALLIMPMLQSCLNDDDESRGTRFTIGTIEVIG
                     EKEYFFNLDDGDKMYPSDTTYIHNYTVENNQRVFIHFLPLEEDIPGYDYNVKLIQLENI
                     LTKDIIPLTEETADSIGNDRINATSLWITGNYLNIEHQFFHSNNPDKKHMLNLVINEMA
                     ETPDTEDEYFTLEFRHNAYNDEQRTPGWGIVSFRLDEITEQLTGKKGLKIIVNTIYDGK
                     QTYTIDLKKE"
     CDS             complement(7004..8020)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AlaDh_PNT_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg176_7"
                     /sec_met_domain="AlaDh_PNT_C (E-value: 4.3e-09, bitscore:
                     25.8, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_N (E-value: 2.4e-33, bitscore: 104.3,
                     seeds: 68, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.7e-30, bitscore:
                     95.6, seeds: 88, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKAVQIVNPSEMKVVELEKPVVGAGEVLVRIKYVGFCGSDLNTFL
                     GRNPMVKLPVVPGHEVGAVIEEIGPDVPAGFEKGMNVTLNPYTNCGKCASCRNGRVNAC
                     EHNETLGVQRNGVMCEYAVLPWTKIIPAGNISPRDCALIEPMSVGFHAVSRGQVIDNEY
                     VMVIGCGMIGIGAIVRAALRGAIVIAVDLDDEKLELARRMGASHTVNSKTEDVHSRIQE
                     ITEGFGADVVIEAVGSPVTYVMAVDEVAFSGRVVCIGYAKSEVAFQTKYFVQKELDIRG
                     SRNALPADFRAVINYMKAGTCPVEELITKVAVPEDALEAMTEWAANPGKVFRILVQL"
     CDS             complement(8044..9303)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_functions="transport (smcogs) SMCOG1058:Major
                     facilitator family (Score: 74.3; E-value: 2.9e-23)"
                     /gene_kind="transport"
                     /locus_tag="ctg176_8"
                     /sec_met_domain="MFS_1 (E-value: 6.6e-24, bitscore: 74.3,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKNTYTIPLALVFCLFFLWAISSNLLPTMIRQLMKTCELNTFEA
                     SFTETAYWLAYFIFPIPIAMFMKRYSYKAGIIFGLLLAALGGLLFFPAAMLKAYWAYLC
                     IFFIIATGMCFLETAANPYVTVLGAPETAPRRLNLAQSFNGLGAFISAMFLSKLILSGT
                     HYTRDTLPVDYPGGWQAYIQVETDAMKFPYLMLALLLVIIAVVFVFSKLPQIGDESKTP
                     SSGSKKEKLIDFGVLKHSHLRWGVIAQFFYNGGQTAINSLFLVYCCSYAGLPEETATTF
                     FGLYMLAFLVGRWIGTGLMVKFRPQDMLLVYSLMNILLCGVVMIWGGMVGLYAMLAISF
                     FMSIMYPTQFSLALKGLGDQTKSGSAFLVMAIVGNACLPQLTAYFMHANEHIYYAAYCV
                     PMICFIFCAYYGWKGYKVID"
     CDS             complement(9320..10243)
                     /locus_tag="ctg176_9"
                     /transl_table=11
                     /translation="MDYTIIDAHAHLWLRQDTVVDGFPIRTLDNGRSLFMGEIRQMVPP
                     FMMDGVNSAEVFLSNMDYAQVAAAVITQEFIDGIQNEYLAEVISRYPDRFFVCGMCEFR
                     KSGFLAQAKELIARGFKAIKIPAQRLLLKEGRVMLNSEEMMRMFRYMEERDVMLSIDLA
                     DGATQVPEMQEVIQECPRLRIAIGHFGMVTRPDWEEQIRLALHPNVMIESGGITWLFND
                     EFYPFKGAVKAIRKAAELVGMEKLMWGSDYPRTITAITYKMSYDFIVKSPDLQEDEKRL
                     FLGENARKFYGFTDLPVLPYIKNMSE"
     CDS             complement(10261..11193)
                     /locus_tag="ctg176_10"
                     /transl_table=11
                     /translation="MQYHEIGKTGMKVSSLSFGASSLGGVFHDVKEKEGIEAVFTAVES
                     GMNFIDVSPYYGHYKAETVLGKALKDIPRDRYYLSTKVGRYGKDGVNTWDYSAKRAVES
                     VYESMERLNIDFIDLINVHDIEFADLNQVVNETLPALVELREKGVVGHVGITDLQLENL
                     KWVIDHSPSGTVESILNFCHYCLCDDKLADFLDYFESKGIGVINASPLSMGLLSERGVP
                     AWHPAPELLVDACRKAMEHCKAKNYPIEKLAMQFSVNNPRIATTLFSTANPLNVKKNVS
                     FIEEPIDWTLVHEVQEIIGEQQRVSWANS"
     CDS             11375..12391
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LacI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peripla_BP_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1043:Periplasmic binding protein-like domain (Score:
                     118.9; E-value: 9.1e-37)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg176_11"
                     /sec_met_domain="LacI (E-value: 2.6e-13, bitscore: 39.6,
                     seeds: 22, tool: rule-based-clusters)"
                     /sec_met_domain="Peripla_BP_3 (E-value: 2.1e-37, bitscore:
                     118.9, seeds: 83, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEYRKHTSLKDLAQALGVSIPTVSRALKDSPEISSELCAKAKKLA
                     KEMNYRPNPFAMSLRKNTPRIIGVVVPDIVTHFFASILNGIENMAVDNGYFVIITTSHE
                     SYEYEKRNIENLVNMRVEGIIACLSQETTDYAHLAALKDINMPLILFDRVCLTDQFSSV
                     VADGVQSAQMATQHLLDTGSKRVAFIGGANHLDIVTKRKHGYLEALRDNRIPIEKELVI
                     CRKIDYEEGKIATEALLSLPQPPDAILAMNDTLAFAAIEVIKSHGLRIPEDIAIMGYTD
                     EQHANYVEPKLSAVSHQTYKMGETACRLLIDQIKGDRTVRQVIIPTNLQIRESSRKK"
     CDS             complement(12669..13526)
                     /locus_tag="ctg176_12"
                     /transl_table=11
                     /translation="MAERNFLEIHSFLNGKDDIKSIKNDFCVFSYEKDIIPPYPIKNNM
                     YVCCIVTRGEARGRINLLPCTLKSQAMCITMPGYILEHEYMSDDFQCICIMLSERFLSG
                     LGLSYDFQTHLFIQENPILNLTDEHFTPIISYCNMVRNILGSRNPYKKETVKHLTCAFF
                     YGLGYYFYEKAENRKLTNDEILMQKFLKEVQQFYKQERKVIFYANKLCLSAGYLSTVIK
                     KVSGRTVADWIDDYVILEAKALLKSGKLTIQQISDELNFPSQSFFGKYFKRIAGVSPKE
                     YKNG"
ORIGIN
        1 aaccccgggt acctcgcagt acaacggttt tcaagaccgc cgcaatcgac cactctgcca
       61 cctctccaaa actcctcttt caagaagtgc tttcctctta aagcggtgca aaggtacgat
      121 ttttttttat atcacaaaca tttccgcaca aaaatcatct tctataccta aaataatata
      181 tatacaagga gattagttga tgcaacgaat cctatccatt acaaataagt aaaatcactg
      241 taaagcaaat caggaacagt ttcaatagaa ctaccatttt agtataagtt aatcattacc
      301 aaggcactgc aatgacatgt gcgttcccgc gctcgaaaac cgtcgttacc acgaagagaa
      361 acgagcgttc ccattaaagg aaacttcaac gcattatata tcaacaaaat agaacgctta
      421 tacgaagcca gaaataacct ctttagtctc cccaattata cccatccaca taatcatcaa
      481 agtagtcatc caactggagt ccgcattctt tggccagacg aatgatatac tgctggtcgg
      541 caggctttat caaccagtca cctttacggg caagatagta gttcctgcgt ccgaggtgtg
      601 aaatgagccg ccatctgaat gtaccagaga cactcactgt cagggaattc aataattgtg
      661 tgaatccttt agcataacgc accggcttgt tcgaacgata atattcgcat tttcccttca
      721 tggcttgcag tttttgagga gtcagggtgg gcaggaacgg atattttacg ggagcatgct
      781 ccaaggctat gtggcgcaga caagtagaag tcttagggca atcggcagat gcacataagc
      841 caaaaccata gggcacttgc gagtaatcga atgtttccat atcgtattta ttaatagttg
      901 acggcaaagg taaacagaat aaatcgggaa aaagaggaaa agattgaaaa gattgaagag
      961 aaacaaaagg aggaagtgat ggcaagtgct gaaagtggca tacctaacaa tagttatttt
     1021 atgctgttca acataaaaaa ggcatatata tccatactat tacggaaata tttccgtaat
     1081 ttagcagccc caaaaggata acattacatt tacccactaa caaaatgaat attatggaat
     1141 tgaacaaaac ctttatcgac gggctttgga gcaaagaaat caatgtcagt gatttcgtga
     1201 gtaaaaacat cgcgccttat actggagacg cttctttcct gcaaggacct accgaacgta
     1261 ccaaacatat ctgggagctt tgcctcaaag cgctcgaaga agaaagagct aacaacggag
     1321 tacgttctct cgacccccac accgtatcca ctatcacttc acatcaggcc ggttatatag
     1381 ataaggagaa tgaacttatc gttggtttgc agacggatga actgttgaaa cgtgccatca
     1441 agccattcgg tggtatcaat gtagtagcta aagcttgccg cgaaaacggc gtagaaatag
     1501 atgataaagt aaaggatatc tttacccatt atcgcaagac acacaatgac ggcgtattcg
     1561 acgtatatac tgaagagatc cgctcattcc gttcattagg tttcctcacc ggacttcccg
     1621 ataactatgc ccgcggacgt atcatcggcg actaccgtcg tctggcactt tacggcatcg
     1681 accgcctcat cgaagccaaa atggaagatt tacacaacct gaccggtccg atgaccgacg
     1741 cccgtattcg cctgcgtgaa gaagtggcag agcagatcaa ggctttgaaa gatattaaga
     1801 taatgggaga atattacgga ctcgacctca gtcgtccggc tacttcggca caggaagccg
     1861 tacaatgggt gtacatggct tatctggccg ctgtaaaaga acaagacggt gcagccatgt
     1921 ctctgggtaa cgtttcttcc ttcctagaca tctttattga atacgatctg gcacacggta
     1981 aaatcaatga aacatttgtc caggagctga tcgaccagtt cgttatcaaa ctccgcatgg
     2041 tgcgccatct gcgtatgcag tcatacaacg atatctttgc cggagacccg acctgggtaa
     2101 cggaagccat tggcggacgt ttcaacgacg gacgtgtaaa ggtaacaaag acttccttcc
     2161 gcttcctgca aacactgtat aacctcggtc cttctcccga accgaacctt accatacttt
     2221 ggggacctga actccctgaa ggcttcaagg aattctgtgc acaagtatcc gtagatacca
     2281 gctccatcca atacgaaaat gataacctga tgcgcgaagt acgtaactgc gatgactatg
     2341 gtatcgcatg ttgtgtatcc tatcaggcta tcggcaaaca gatacagttc ttcggggcac
     2401 gtgccaacct ggcaaaagcc ttgttgcttg ccatcaacgg cggacgttgc gaaaataccg
     2461 gtactgtcat ggtaaaaggt attcccgtat tgaccggtga aacattgaag tttgaggaag
     2521 taatgtcgaa ctacaagaaa gtgctaaccg aaattgcccg tgtttacaat gaggcaatga
     2581 acatcatcca cttcatgcac gataagtatt attacgaaaa ggctcagatg gcatttatcg
     2641 atacgaatcc acgtattaat ctggcttatg gcgtagcagg tctttccatt gccatcgact
     2701 cactgtcggc catcaagaat gcaaaggtta cagcccgtcg caacgacatc ggcttgacgg
     2761 aaggtttcga tatcgacggt acattcccat gtttcggtaa caatgacgac cgtgtggacc
     2821 acctcggggt agacttggta tattatttca gtgaagaact gaagaaattg cccgtttaca
     2881 agaatgcccg tcctaccctt tcattgctga cgattacttc taacgtaatg tacggtaaga
     2941 agacaggtgc cactcctgac ggacgtgcca aaggtgtagc tttcgccccg ggtgccaacc
     3001 cgatgcacgg acgcgataag aacggcgcca tagcatcact gagttccgta gccaagttgc
     3061 gttatcgcga ctcacaggac ggcatcagta atacattctc tatcgtcccg aaatctctcg
     3121 gcccgacacc ggaagaccgt gttgaaaacc tggtaacaat gatggacggt tactttacta
     3181 aaggtgcaca ccacctgaac gtaaacgtgc tgaaccgtga aatgttggaa gatgccatgg
     3241 aacatccgga gaagtatccg caactcacaa tccgtgtttc cggctatgct gtgaacttcg
     3301 tgaaactgag ccgcgagcat cagttagaag ttatcagccg tagtttccac gaaagaatgt
     3361 aatatgataa acgtacactc ctacgaaagt atgggaacat tcgacgggcc gggtctccgg
     3421 ctcgtcgttt tcctgcaagg ctgtccgttc cgttgtctgt attgtgccaa cccggataca
     3481 atagacgcaa aagggggaac acctacccca ccggaagaaa ttctgcaaat ggctatcagc
     3541 cagaaagtat ttttcggaaa aaagggtggc atcacattct cgggtggtga gcctacatta
     3601 caggccgaag cgcttatacc tctgttcaaa gatttgaaag caaacggcat tcacatctgc
     3661 ttggatacca atggcggtat ctggaatgaa aaagttgaag aactattgag tctgacggat
     3721 ttagtgctgc tggatctcaa agaattcaat cccgaacgcc ataagaggct gaccggatgc
     3781 aacaatgcaa aaactttaca tacagcagct tggctagagg aacagaaccg gcctttctgg
     3841 ctacgctatg tattagtacc gggatatagt gattttgagg aagacattcg cagtttaggc
     3901 gaacatcttg gtcaatataa aaatatacag cgaatagaaa tacttcccta tcatcgcctg
     3961 ggcgtgcata agtacgaagc tatgggatgg gattaccagt tgaaagaagt aaaagaaaat
     4021 actcccgaac aactggaacg tacggaaaag ttattcaagg aatacttcga aacggttata
     4081 gtaaactaag agaaattcac tttatcaccc tatcactctt tattcatact gattagtaag
     4141 tcagacggat acctgcctgc aacgtaaagt tcatcgggtt ttccttccgt atagtctcta
     4201 tcggagaacc atcgtcaaag aaataggaaa caccgggctc tacatatatt cccactctat
     4261 tactaatatt atattgagcg cctaccgcac ccattacaga taattgcacg ggtttcaccg
     4321 tttccttttc gcttcctacc ttaccataga cacacttctc tattgcacca ccggcagata
     4381 catataccgt gaaacgtttg tcattaacga aactccagtt cgcacgcacc ggaataccga
     4441 tatagtgcag tttttgatct gtcttttccg aactattttc atatgttatt tcagacgaca
     4501 gcatcgtata agtcacaccg gtttccacag aaaagttttt cggtaatgct ttccgtaccg
     4561 ataagccgaa actaagaggt tgcttatgct tgatattttt aacctgacgg gtatttttcc
     4621 gcagataagg tactccacct tcaaaaacca gttcttgtcc ttcaggaata tccagaatac
     4681 cactggaaac attcggtaaa tccagtttat cactaaacat cggagttgaa ttcggacctg
     4741 agtgcatacc gccatttgta ttatccagcg atgcaagtgc tcctgtattt cctacagaca
     4801 tgccaaccgc ccaaccttta tttccggtag atgatttctt ttcagtaggc aaatggagtt
     4861 tatccctgct ggaaggacga tatacttcgc gttcttcctt ttccggaatc gaagatgaag
     4921 tttccgtttc ctttgcctgt tccgtttttc ccgtttcttc tgtcacattt gaattcaaat
     4981 ctgaattcac tatttcttct tgtcggttca catttacttc ctgaacattg ctttccgtct
     5041 ccaaatgctg cgctacaaga gcttgatgac gagaatcccc ttgttcaatt actcgccgga
     5101 taacaggttc cggctgttct ccttgagtat ccggctttgt ctgttccggc aatacatcag
     5161 gtatcgttgc cagaaccggt tcagctgcac gacgcacctc gtccactacc ggactttgca
     5221 gcaaccacaa gctaacagac gatacagcca ccagcacaac tgccgcagcc gtcatcgccc
     5281 aacgacggaa catgatctgt ttcttcttcc ctacagacat gggtgcggag acaggcaata
     5341 ccttctccaa ccgttcccag ccggtatcag gcaacggttc ggaataatca tccagccgct
     5401 cctttatctt tttcaaccac aattcatcat ctttcatcat acgtcctttc cttcattaaa
     5461 cattgttctt catccactcc cgtacttttg tagccaaagt agctttagca cgtgtcagct
     5521 gcgaagccga tgacttctca ttaataccca gcatctgggc aatttcctta tgagactttt
     5581 cttcaaatat atataagttg aatacggtgc gataaccggc aggtaattca ctgataaact
     5641 gcatcagcac cttctgggga atagtttcca ctgtcgaagc atcgggttcc tcgtacgttt
     5701 caggtatgtt gtccaacccc tccgactggt ttattacatc attcttgcgc aagtattgca
     5761 gcgccgtatt caccataaca cgctccatcc acgcccgcaa ggatccatca cctcgccaag
     5821 tgaatttatc aaaagaatcg aagagcttca ggaaaccatc gtgcatgagg tcttctgctg
     5881 tatcacggtc acccgcataa cgaagacaca cgctgagcat ccgccctgca tagcgctcgt
     5941 acagctcctt cctggcaagg ttgtcgcctt gcctgcaccg tcctgccagt tcctgttctt
     6001 ccattctttc ctttgacacg tgtttacctt ataaatgcgg caaagataga aatactgcac
     6061 gtagcgagca agaaattaac tcttttgttt ctttaacagt cctttatgca gtatttaccc
     6121 tcacattgca ttttttaaat acatgtagaa aataagatta acaccaaaaa acaacaattg
     6181 atgaagaagc tgagatttta ttcggtagta tttacacttg cacttttaat aatgccgatg
     6241 ttacagtctt gtctgaatga tgatgacgaa agtcgtggta cccgtttcac aatcggtact
     6301 atagaagtta taggagaaaa ggaatacttt tttaatctgg atgacggtga taagatgtat
     6361 cccagtgata ctacttacat ccataactac acagtggaaa acaaccaacg tgtatttatt
     6421 catttccttc cattggaaga agatatcccg ggctatgact ataatgtgaa acttatccaa
     6481 cttgagaaca tactgacaaa agatattatt ccacttaccg aggaaacggc tgacagcatc
     6541 ggtaatgacc gtatcaatgc tacctcatta tggattacag ggaattatct gaacatagaa
     6601 caccagttct tccacagcaa taatccagat aagaagcaca tgctgaacct ggtcataaat
     6661 gaaatggccg agacacctga tacggaagac gagtatttca ctttggaatt ccggcacaat
     6721 gcttataacg atgaacaacg tacgccgggt tggggaatcg tatcattcag actggatgaa
     6781 ataaccgagc aattgacagg aaagaaagga ttaaaaataa tcgtcaatac gatttatgac
     6841 ggaaaacaaa cctatacgat agatctgaaa aaagagtaaa ataggattaa acaataagag
     6901 accaacctaa actgaccgat tgaagacgga gagggtgcat tcctacagtg aatgccccct
     6961 cttttacttc aaaaaagcct tatttaaaag accttgaaat ctcttataac tgtacaagga
     7021 tacggaatac ttttccagga ttagccgccc actccgtcat agcttccaat gcatcttcag
     7081 gtactgctac cttcgttatt aattcttcta ccgggcaagt tcctgccttc atatagttga
     7141 ttaccgcacg aaagtcggcc ggcaatgcat ttctggaacc acgtatatcc aattctttct
     7201 ggacaaaata cttcgtctgg aaagcgactt cactcttcgc atagccaatg caaacgacac
     7261 gccctgaaaa agcaacttca tccacagcca ttacataagt cacaggacta ccgacagctt
     7321 caatcacaac atcagctcca aagccttccg taatctcttg aatccgacta tgcacatctt
     7381 ccgttttaga attaaccgta tgagacgctc ccattctccg agccagctcc aacttctcat
     7441 catccaggtc cacagcaata acaatggcac ctctgagagc ggcacgaaca atagcaccta
     7501 taccaatcat accgcaacca atgaccatca catattcatt gtcaatcacc tgaccgcgcg
     7561 aaacggcatg aaatcccaca ctcatcggct caatcaaggc acaatcacgc ggagagatat
     7621 tacctgccgg aataatttta gtccaaggca atacagcata ctcacacatc acgccattcc
     7681 gctgcactcc taatgtttca ttatgttcgc aggcattgac acgaccattg cggcacgaag
     7741 cacatttacc acaattagta tatggattca gagtcacatt cattcctttt tcaaagcctg
     7801 ccggaacatc cggacctatt tcttcaatga ccgcgcctac ttcgtgcccc ggcactacag
     7861 gcaacttcac catcgggtta cgccccagga aggtgttcaa atcggaacca cagaaaccta
     7921 catattttat tctcactaac acctcaccgg caccaaccac cggtttttca agttcaacca
     7981 ccttcatttc agagggattg actatttgaa ctgctttcat tttatatatt tgaaattaat
     8041 tgtttaatca ataaccttat aacctttcca gccatagtag gcacagaata taaagcaaat
     8101 catcggtaca cagtaagctg cataataaat gtgctcattg gcgtgcatga aataagccgt
     8161 caactgaggg agacaggcat taccgacaat agccatcaca agaaaagccg aaccactttt
     8221 tgtctggtcg cccaatccct tcagagccag agagaactgg gtaggataca taatagacat
     8281 gaagaaagag atagccagca tagcatataa tcctaccata cctccccaga tcattaccac
     8341 tccgcataaa agaatattca ttaaggaata aaccaacaac atatcctgcg gacggaattt
     8401 caccatcagt cctgtaccaa tccagcgccc tacaaggaaa gcaagcatat aaagtccgaa
     8461 gaaagttgtt gcggtttctt ccggaagtcc tgcataagaa cagcaataga caaggaataa
     8521 actgttgatc gctgtctgcc cgccattgta aaagaactgc gcaattactc cccaacgcaa
     8581 gtgtgaatgt ttcagcacac caaaatcaat cagcttttct ttctttgaac cggaagaagg
     8641 agtcttactt tcatctccta tctgcggcaa tttggaaaat acaaatacca ctgctataat
     8701 caccaacagc aaagccagca tcagataagg gaacttcata gcatccgtct ctacttgtat
     8761 ataagcctgc cacccacccg gataatctac gggtaaagta tcacgtgtat aatgcgtgcc
     8821 actcagaatc agtttactca gaaacatagc agagataaag gcgccgagtc cgttgaaaga
     8881 ttgcgccagg ttcaaccgcc gtggtgctgt ttcgggcgca cctaaaacgg taacatacgg
     8941 attggcagca gtctccagga aacacatacc ggtagctatg ataaagaata tgcagagata
     9001 ggcccaatag gctttcaaca tggcagccgg aaaaaagagc aaaccaccca atgccgccaa
     9061 caataaaccg aaaataatgc ctgctttgta gctataacgc ttcatgaaca tagctatcgg
     9121 aatcgggaaa atgaagtaag caagccaata ggcagtttcg gtaaatgacg cctcaaaggt
     9181 gttcagttca caggttttca tcaactgccg tatcattgtc gggagcagat tgctgctaat
     9241 tgcccaaagg aaaaaaaggc agaagaccag cgccaaaggt atcgtataag tatttttttt
     9301 catacgtatt attatcttct tattcagaca tgtttttgat atatggcaat acgggaagat
     9361 cagtaaatcc atagaatttc cgggcatttt ctccaaggaa cagccttttt tcatcttcct
     9421 gcaaatcggg tgatttcact ataaaatcat acgacatttt gtaagtgatt gcggtaatag
     9481 tacgcggata atccgatccc cacatcagtt tctccatccc gaccagttcg gcagctttcc
     9541 gtatagcttt taccgctccc ttaaaaggat agaactcatc attgaaaagc caggttattc
     9601 ctccggattc aatcatcaca ttgggatgaa gagccagccg tatctgctct tcccaatccg
     9661 gacgtgtcac cattccgaaa tgcccgatag caattctcaa ccggggacat tcctgaataa
     9721 cctcctgcat ctcgggaact tgcgttgctc cgtccgccaa gtctatggaa agcatcacat
     9781 cccgttcttc catatagcgg aacatccgca tcatctcttc actattcagc atcacccgtc
     9841 cttctttaag caacagacgt tgagccggaa ttttaatagc tttgaaacct cttgcaatga
     9901 gttcttttgc ctgtgccaga aacccggact tacgaaactc acacattccg caaacaaaga
     9961 agcgatcggg ataacgggaa ataacttctg ccagatattc attctgaata ccatcaataa
    10021 attcctgtgt aatcacagca gcagccactt gcgcatagtc catgttcgac aggaaaactt
    10081 ctgcactatt caccccgtcc atcataaagg gaggaaccat ttggcggatc tctcccataa
    10141 acaacgagcg tccattatcc agtgtacgaa tgggaaaccc atccaccact gtatcttgcc
    10201 gcaaccataa atgggcatgg gcatcaatta ttgtatagtc catatagaca gctgtttttt
    10261 ttaagagtta gcccaactta cgcgttgctg ttccccaata atttcctgta cttcatgcac
    10321 cagcgtccag tcaatcggct cttcaataaa agagacattc tttttcacat tcagcggatt
    10381 ggccgtactg aacaatgtag ttgcaatccg aggattatta acagaaaact gcatagctaa
    10441 tttctcaata ggataattct ttgccttaca gtgttccatt gctttgcgac aagcatccac
    10501 caaaagttcc ggagccggat gccatgcagg aacgccccgt tcactcaaca atcccatgga
    10561 tagcggagag gcatttatca cacctattcc tttcgattca aaataatcaa gaaaatccgc
    10621 tagcttgtca tcgcacaggc aataatggca aaaattgagt atagattcta ccgtaccact
    10681 gggcgagtgg tcaattaccc atttcaagtt ttcaagttgc aagtcagtga ttccgacgtg
    10741 tccgacaact cctttttcac gcagttctac caatgccggt aatgtctcat taacaacctg
    10801 gttcaaatca gcaaactcaa tatcgtgcac attaatcaaa tcgataaagt cgatattcag
    10861 acgttccatg ctctcatata cactttctac cgcacgtttt gcagagtaat cccaagtatt
    10921 gacaccatct tttccataac gtcccacttt ggtagaaaga taataccggt cacgtggaat
    10981 gtctttcaag gcctttccta aaacagtctc tgctttataa tgcccataat aaggggagac
    11041 atctataaaa ttcatgcccg attcgacagc agtaaacaca gcctcaattc cttctttctc
    11101 tttaacatca tggaaaaccc ctcctaaaga agaagctcca aaactgagag atgatacttt
    11161 catccctgtc tttccgattt catggtattg cataactaat taaatttaaa agtttttaga
    11221 tgcgacaaaa ataggacaag aataaattca ggacagcata taagaagcga aaacaatacg
    11281 taatggttta cgtaaaaaaa acatccttct atactgtctt ttatcgggga atgtgttttc
    11341 tttgtaaacg aatctaatat agcagactta aaacatggaa tatcggaaac atacttcatt
    11401 aaaagatctc gcccaagcat taggcgtatc catccccact gtatccaggg cactaaaaga
    11461 cagtcctgaa atcagcagtg agctttgcgc taaagccaag aagctggcaa aagaaatgaa
    11521 ttaccgcccc aacccttttg ccatgagtct gcgaaagaat accccgcgta tcattggagt
    11581 cgttgtaccg gatatcgtta cccatttctt cgcatccatc ctgaacggga tagagaatat
    11641 ggcagtggac aacggatact ttgtcatcat caccacttca catgaatcct acgaatatga
    11701 aaaaaggaat attgagaatt tagtcaatat gcgggtagag ggtatcattg cctgtctgtc
    11761 ccaagaaact acagattatg ctcatcttgc tgccctgaag gacattaata tgccactcat
    11821 cctcttcgac cgtgtttgcc tgaccgacca gttttcttcg gtagtagcag atggagtgca
    11881 atcggcacaa atggctaccc aacatttatt ggataccggt agtaaacgag tggctttcat
    11941 aggaggagct aaccatttgg atattgtgac aaaaagaaaa cacggttacc tggaagctct
    12001 ccgtgacaat cgtattccca ttgaaaaaga actggtaatc tgtcggaaaa tagattatga
    12061 agagggtaaa atagcaacgg aagccttgtt atcccttcct caacctcccg atgccattct
    12121 tgccatgaat gacacattag cctttgccgc catagaagtt attaaaagtc acggccttcg
    12181 cattccggaa gatatagcta tcatgggtta tacagacgaa caacatgcca actatgtaga
    12241 accgaaacta tcggcagtat cacatcagac ctataaaatg ggagaaacgg cttgtcgttt
    12301 attaatagac caaatcaaag gagatagaac agtcagacaa gtaatcattc cgacaaatct
    12361 acaaatcagg gaaagtagta gaaagaaata acaaaaacgg tttatcaacc tgcggagaga
    12421 cggggtaatg aacccatctc cttatatcgt tcaaactcaa ctctttatca atatatcaat
    12481 gccttagggg gtacaattta ggtttcaaaa aagacgttta tctgtcgtcc tttggctgtt
    12541 cattgtctgc ctaaaacttc ggttcaaaga tactgcttct ttttgaatta cgcaaatgtc
    12601 tgaatataaa tgtttagcga ttagtgcaag gtgcaagcta catatagata tatacttgca
    12661 ccttgcactt acccgttttt atattcctta ggtgatactc ctgctattct tttgaaatac
    12721 tttccaaaaa aagattgaga tggaaaattc aactcatcgc taatttgttg tatagtcagt
    12781 ttgccagatt ttagtaaggc tttcgcttcc agtattacat aatcatcaat ccaatcggct
    12841 actgtacgtc cactaacttt ttttattacc gtagaaagat agcccgcaga taaacatagc
    12901 ttgtttgcat aaaatataac ttttctttct tgcttataaa actgctgaac ttcttttaaa
    12961 aatttctgca ttagaatttc gtcattagtt agttttctgt tttctgcttt ttcataaaaa
    13021 taatatccta atccataaaa aaatgcacaa gtgagatgtt ttactgtttc ttttttatag
    13081 ggatttctgc tacctaatat attgcgcacc atattgcagt acgatattat aggagtaaaa
    13141 tgttcgtctg ttagatttag tattggattt tcttgaatga aaagatgagt ttgaaaatca
    13201 tatgataatc ctaatccact aagaaatctc tctgatagca taatacatat acactggaaa
    13261 tcatcgctca tatattcatg ttcaagaata tatcccggca ttgttatgca cattgcttgt
    13321 gatttcaacg tgcaaggaag taagtttatt cgacctcgtg cttctccacg agtcacaatg
    13381 cagcatacat acatattatt ttttattgga taagggggaa tgatgtcttt ttcatacgaa
    13441 aaaacacaaa aatcattctt tatgctcttt atatcatctt ttccatttaa aaaggagtgt
    13501 atttctaaaa agtttctttc agccattttt catcatttag attacaaata taggataaaa
    13561 aagatgattt tacagtataa atataacaaa tcgtccaaat cctccaatga aaagaccttt
    13621 gctacatctt aaaactatat gacctttgca aaatttaaaa gaccattgtc atgaaaaata
    13681 agaataatac aattttatta ctcggtggaa ttaactatgt actattacaa atacagaagt
    13741 tctgcacagg aatactaaaa gtacataatc aaattaacaa acaaatctgt tttatacgaa
    13801 ttttgttttt aatattgggt ggcatatcac caatatacag taatgcacaa gtaataaccg
    13861 attctttagc taatgatatt agaagtttta cagcacgcaa tatttcaaga taccgtactt
    13921 tgaatttata ctgggaaaca aagggaatgc atgattacac gcttaaaatg aatgggaaag
    13981 atgttgagaa aggaagaaaa aacgatttac atacaatcaa attttcaaca atgttcccta
    14041 ttttgaaaca aagaaatatt tcactatatg ccaatcttca atataattg
//
