LOCUS       c00020_NZ_CBYM..       14723 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CBYM010000020.1 Clostridium saudiense strain JCC, whole genome
            shotgun sequence.
ACCESSION   NZ_CBYM010000020
VERSION     NZ_CBYM010000020
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-03-14 01:06:27
            Original ID  :: NZ_CBYM010000020.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14723
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14723
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2679:4723]"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [Flavoprotein,
                     Semialdhyde_dh]) and gallic_acid)"
                     /neighbourhood="10000"
                     /product="gallic_acid_met"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2680..4723
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [Flavoprotein,
                     Semialdhyde_dh]) and gallic_acid)"
                     /neighbourhood="10000"
                     /product="gallic_acid_met"
                     /protocluster_number="1"
     cand_cluster    1..14723
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [Flavoprotein,
                     Semialdhyde_dh]) and gallic_acid)"
                     /kind="single"
                     /product="gallic_acid_met"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14723
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="gallic_acid_met"
                     /region_number="1"
                     /rules="(minimum(1, [Flavoprotein, Semialdhyde_dh]) and
                     gallic_acid)"
                     /tool="gutsmash"
     CDS             2..151
                     /locus_tag="ctg20_1"
                     /transl_table=11
                     /translation="KASALLLNTNFTVTDISYMVGYDNKEHFIRTFKKNFGVSPTQHRK
                     GIKN"
     CDS             256..1164
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ROK"
                     /gene_functions="other (smcogs) SMCOG1034:Repressor, ORF,
                     Kinase (Score: 142.4; E-value: 7e-44)"
                     /gene_kind="other"
                     /locus_tag="ctg20_2"
                     /sec_met_domain="ROK (E-value: 5.5e-44, bitscore: 142.4,
                     seeds: 11, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGNKYLVLDIGGSSIKYALMTECVEFLEKGKVATPQDSIESFVNV
                     IGDLYDKYKDKIEGIAISMPGLIDSKNGYARTGGWLRYNDDKYIVKILQERCPTKITIQ
                     NDAKSAALAEVWKGSLKEYNDGIVVVLGTGVGGAVVKDRKILNGKHFFAGEFSYIWTDT
                     TFAIDSTDNMWGYVNGASALNGAVAMAKNLAKEEVDGFKVFELVNSGDKEAIDVLDKFT
                     YQLAAQLYNLHCVLDTEVIAIGGGISEQDILIEYIQKNIEKIFDKVPFDIPRVKVVRCK
                     FRNDANLIGALYNFLGLEDKQ"
     CDS             complement(1246..2115)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HTH_1"
                     /gene_functions="regulatory (smcogs) SMCOG1012:Bacterial
                     regulatory helix-turn-helix protein, lysR family (Score:
                     67.6; E-value: 2.4e-21)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg20_3"
                     /sec_met_domain="LysR_substrate (E-value: 1e-35, bitscore:
                     114.6, seeds: 361, tool: rule-based-clusters)"
                     /sec_met_domain="HTH_1 (E-value: 1.9e-21, bitscore: 67.6,
                     seeds: 1330, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIESLKYFLSVEKYNSFSLAAEELCISQSSLSKHIKKLESELNC
                     VLFERCTRHVKLTDAGISLKKYAINIVSNYDELILDLNKFTSSFPKLSIGYIPVINQYN
                     IAKLIGSFKNTVTDLQLTFHEGEHADILNLLFSQKIDFAFLRSDTLDYSNLDITPLAQD
                     ELVLIVPKSHPLSKRKYVSISELSNESFISLGKNSGVYDFFVSECMKASFEPNVVCFNS
                     RIENIIGLVSAGMGISPLMRKTVECFDKKNISVVLLKEKIHSNLCLVHLKDKKLSKIEK
                     NFKDYLSK"
     CDS             2312..2683
                     /locus_tag="ctg20_4"
                     /transl_table=11
                     /translation="MIKIERCYKNINIKLEAIFVGDDLCAVVTGGDKPHVGAISVYSKE
                     EGIKTISLKNHKDYIIGEIFINSIKDSFNGNISVSCGIHIDNISKEQIEDVYECCNKIF
                     QESKVELYKVTTNLNEVEK"
     CDS             2680..3249
                     /gene_functions="biosynthetic (rule-based-clusters)
                     gallic_acid_met: Flavoprotein"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg20_5"
                     /sec_met_domain="Flavoprotein (E-value: 1.8e-26, bitscore:
                     84.4, seeds: 91, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNLVIGVTGATGTVYAVRLLEYLKDIEEIKTHLIMSKWAINNLEV
                     ETDYSLDYVYDLADFIHNNDELGACVASGSFLTDGMIILPCSMKTLSSISNGFSTTLID
                     RAADVMIKEGRKLVISPRETPLSSIHLENMLKLSKLGVRIVPPMPGFYSNPKSLDDIIN
                     HHIMKILDQFNINIRNDLRWKVNEYE"
     CDS             3236..4723
                     /gene_functions="biosynthetic (rule-based-clusters)
                     gallic_acid_met: gallic_acid"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg20_6"
                     /sec_met_domain="gallic_acid (E-value: 4.2e-242, bitscore:
                     794.7, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSMNKVEINDLRSAIEYLKDIKGQLVKSDVEVNPHGELAGVYRYV
                     GAGGTVRRPTKIGPAMIFNNIKGHKDAKVIIGLLASRERVGMLLGCESKKLGFLLNEAV
                     KNPINPIIIENENAPCQEVVHYATDEDFDIRKILPAPTNTEEDAGPYITLGMCYARDPE
                     TGEGDVTIHRLCLQGKDELSMFFTPGVRHLDAFRKKAEESGQPLPISISIGVDPAIEIA
                     SCFEPPTTPIGFNELSIAGAIRKKPVEMVKCLTVDEAAIARAEYVIEGELVPNKRVRED
                     MNTNTGKAMPEFPGYTGEAAKELPVIRVKAITHRKNPIMQTCIGPSEEHVNMAGIPTEA
                     SIIQMVEKAMPGRLVNVYAHPAGGGKYMAILQIKKSMASDQGRERQAALLALSAFSELK
                     TVILVDEDVDPFDSNDVLWALNTRYQGDIDTIFIPGVRCHPLDPSQSPEYSWTIRDRGI
                     ACKTIFDCTVPYELKDKFKRAKFTEVDLEKFKIEDYK"
     CDS             complement(4769..5107)
                     /locus_tag="ctg20_7"
                     /transl_table=11
                     /translation="MKKCKIEVLKTTFHEDLAKQYGCKNLGKCPMHKVGDIFYGDYSKP
                     EGLCDEAWKAMYQYVFAISHGCDKFYYEDWIDQKGIAICSCNDGIRPVIFKIESTNEQS
                     KINYEPIK"
     CDS             5238..5579
                     /locus_tag="ctg20_8"
                     /transl_table=11
                     /translation="MSMKDLENSDLTDIKSTPFGYTLSIIGGKWKMIIMFWLVEYEVLR
                     YGELKRCIGQISDKILNNQLKELEKDGIIIRKEYPQIPPRVEYRLSKRGLSLMPILEEM
                     CKWGEVNKI"
     CDS             5875..6714
                     /locus_tag="ctg20_9"
                     /transl_table=11
                     /translation="MGCKRAKNKKDKEQIKNISKSDEFQLSLLNLQVKIILIYMISNIF
                     LFGGTLQSINISCNKKASDSNPNILLIEGQYLALIASILISYVDFSRYNELNERYKKGE
                     INKSLEPEALIKQASILTIILYELNVVVFVEIYKVSLVIDSSKCDKKHIDRLYLQAACF
                     IMRFYGDYFLLSATLKSINLIKSKYDKRIDKIENPDVDAVIAAEIYVIQRGVLYDISCN
                     ELEDLMNSSDEFEKELLLLPKQILVVANIFGVVANIISLIGFIKLYNRNSNEPIFGR"
     CDS             complement(6923..8335)
                     /locus_tag="ctg20_10"
                     /transl_table=11
                     /translation="MNYDLKFNDKKYTIETITLDEKTLKYRAFENIIYVNNPIDTNFQK
                     LSIFVPETYYEGNSIGNYNLNTAPIFFPNTVGGYMPGAPEKPGINKFINKPNATFYALL
                     HGYIVVSPGARGRGLKDKNGKFTGTAPACIVDLKAAVRYLRHNKDIIPGNVEKIISNGT
                     SAGGALSALLGSTGNHPDYESYLKELGAADERDDIFAASCYCPITNLENADKAYEWEFC
                     GINDYHKMKFERIEGSPKPKLVPISGEMNELQIELSKELKSLFPEYLNKLNLKSSNGTL
                     LTIDSEGNGTFKDYIKSFVIKSAQKELNKGKSLSDLKWITIVNNEVTDVDFDKFIKFRT
                     RMKDTPAFDNISMGTPENELFGTPEIQYRHFTEFSKNHSIVNGELSEEAQIKLMNPMNY
                     ISDNSCTTAKNFRIRHGAIDRDTSLAISAILAVTLEMNGVNVDYDLPWGIPHSGDYDLD
                     ELFAWIDNIVSN"
     CDS             complement(8458..9306)
                     /locus_tag="ctg20_11"
                     /transl_table=11
                     /translation="MENLIDLHTHSYISDGSCSPTDVIKAAKKNKLKAISLTDHDSIAG
                     LKEAKIAAEDSNIELINGIEISALYKDGRLLHILGLGIDIHNEYFLNSYNKMKKAREKS
                     VPKILKHIENNHGLSIDINYLHKVKYDEYLSRYDIYRYILENNICTEPQKVWDIYLDPI
                     PYGNDELITVDEAIKMIHEAGGKSYLAHFNKRIGLEGFSFEEIEDNIKYLVSLGLDGIE
                     RYYPSYTDDDRRLLDYLVWKYQLYSSGGTDYHGANRGNIEIGFGEGDLKIPYSLIDSLK
                     R"
     CDS             9456..10415
                     /locus_tag="ctg20_12"
                     /transl_table=11
                     /translation="MRKDIIDKLMELTQEEKEILEGKHSIDQSIYTDDKQFIIDSKKIL
                     ADGQLINIRKHTRFIEFPAHKHNYIEFNYVYKGKLTEVIHNKKIELQEGEIIFLNKDIT
                     HAIEKSSEDDIIINFIIRPEFFDFILNLSESDNIIFNFLLKSLYLNKNSKGEYLYFKVS
                     NENNIQETLEKIIIEIYEPTMMSSTTIKLLVGLLIVELIKKPNNIEVYSEDNYDNLIII
                     EVLKYIDNNYSTATLFEISEIVNQPHYKISKLVKKHTNMTFKELLQEKRLNKAKQLLNE
                     TDISIVEIISLVGYENLTYFYKIFKEKYGYTPKDFRKS"
     CDS             10571..11989
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FGGY_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FGGY_N"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg20_13"
                     /sec_met_domain="FGGY_C (E-value: 3.4e-17, bitscore: 54.5,
                     seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="FGGY_N (E-value: 6e-42, bitscore: 135.5,
                     seeds: 11, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMSYYLAIDMGASSGRHILGSIEDGKIKLEEIYRFENGISKIGDE
                     YCWDIQGLFNEIKKGIKKCKEIGKVPKTIGIDTWAVDFVLLDENDEMLGNAVAYRDDRT
                     EGYMEKAFQVIPQDMLYLYTGIQFQRFNTLYQLLAIKDKNPEYLKKAKTFLMIPDYLNF
                     LLTGKKANEYTNATSTQLVNSFDRTWDKNILKEYGINEEMFQEIKMPKTSLGKLRKELV
                     DEFGFDMEVILPATHDTGSAFISSVCNDSDSIYVSSGTWSLIGVENRFPICVPQAMDYN
                     FTNEGGIDYRFRFLKNIMGLWVIQEVRRNLNNEFSFADLVVLAEEHNYFKSIVNVDDDR
                     FLKPDNMIEEIQNYCKETNQDIPTKVGEIAVCVFNSLGHSYKSAVANLEDIFEKEFKRI
                     NIFGGGCQNNLLNQVVADVTGKEVLAGPVEATAIGNLVAQLISVGELKDLGQARQVIKE
                     SFDINIFKPNKGEV"
     CDS             11991..13247
                     /locus_tag="ctg20_14"
                     /transl_table=11
                     /translation="MNVKERYELAKEQYEKWGINVDKVLEELNKVKISVHCWQGDDVKG
                     FEVVQNALSGGIQCNGNYPGAARSAEELRADLDKALSLIPGKHKVNLHAIYLESNGEFV
                     ERDEIKPEHFENWVNWAKERGLGLDFNPTIFSHPKAADGLTLSHPDKEIRDFWIRHAIA
                     SRKIGEYFGKELGQTCLTNLWIPDGYKDIPSDRLGPRARLKDSLEQIYAVKTNKDYNLD
                     CVESKVFGIGAESYTVGSNEFYLNFAARNGIMSLMDTGHYHPTEVVSDKLSSMLLFDEK
                     VALHVSRPVRWDSDHVVVYDDELKEIAKEIVRNDALDRVIIGLDFFDASINRIAAWTIG
                     TRNMIKALLNAMLTPNELLRKLQDEGNFTERLALMEEFKTYPMGDIWNYYCEKNNVPVG
                     ESWIEDVKRYEEEVLSKRN"
     CDS             13353..14171
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldolase_II"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg20_15"
                     /sec_met_domain="Aldolase_II (E-value: 6.2e-39, bitscore:
                     125.5, seeds: 389, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSMQDMKFVQNFMKMTNDAWLKGWHERNGGNISYRLTSENVESIK
                     NIIDENRDYSPIGVTVKNLANEYFLVTGSGKFIRNVAVDLEANVGIVKIDEKGENYKVV
                     WGLVNGAKPTSELPSHLMSHSVKFEATNGKHRVIMHSHATNLIALTFVLPLDGAVFTRE
                     LWEMATECPVVFPSGVGIVPWMVPGGAEIAEATSELMKKHDVVIWAHHGVFCSGEDLDL
                     TFGLMDTVEKSAEILVKVLSMGGKRQTISSDNFRDLARDFNVTISEEYLK"
ORIGIN
        1 taaggcgagt gctcttttgt taaatactaa ttttactgta actgatatat catatatggt
       61 agggtacgat aataaggaac actttattag aacttttaaa aagaattttg gagtctctcc
      121 aactcagcat agaaagggta ttaaaaatta aaaaaaatca attattttga ataataataa
      181 caattggaag ttaatttaat ataagttaaa atgtaagtag aagtttttaa agtagagtgt
      241 gagggggaag tatttatggg aaataaatat ttagttttag atattggtgg aagttcaatt
      301 aaatatgcgt taatgactga gtgtgttgaa tttttagaaa aaggaaaagt tgcaacacca
      361 caagattcta ttgaaagttt tgtaaacgtt attggtgatt tatatgataa atataaagat
      421 aaaatagagg gaatagcaat aagtatgcct ggtttaatag acagtaaaaa tggttatgca
      481 agaacaggcg gatggcttag atataatgat gataaatata tagttaaaat acttcaagaa
      541 agatgtccaa ctaagattac aattcaaaat gatgcgaaat cagcagcttt agcagaggta
      601 tggaaaggga gtttaaagga gtataatgat ggaattgtag ttgttttagg cacaggagtg
      661 ggaggagcag tagtaaaaga taggaaaata cttaatggaa agcacttctt tgcaggtgaa
      721 tttagttata tatggacaga tactacattt gcaatagata gtactgataa catgtgggga
      781 tatgttaatg gtgcatcagc tttaaatgga gcagttgcaa tggctaaaaa cttagctaaa
      841 gaagaagttg atggttttaa ggtttttgaa cttgttaact ctggagataa ggaagctata
      901 gatgtgttag ataaatttac atatcaatta gcagctcaac tgtataactt acattgtgtt
      961 ttagatactg aagttatagc tatcggtgga ggaattagtg aacaagatat attaatagaa
     1021 tatattcaaa aaaatattga aaagatattt gataaagttc catttgacat tccaagagtt
     1081 aaagtggtta gatgtaaatt tagaaatgat gctaatttaa ttggagcatt atataatttt
     1141 ttaggattag aggacaagca atagtaaaaa aacttcctcc ggagaaagtt tatgaaatga
     1201 actctcgccg gaggtaaatt cattttatag agagaaataa attcattatt tgcttaaata
     1261 gtctttaaaa tttttttcaa ttttagataa tttcttatcc tttaaatgaa ctaagcataa
     1321 attactatgt attttttctt tcaacaaaac aacagaaata tttttcttat caaaacattc
     1381 tacagttttt ctcataagtg gagaaatacc catgccagca gaaacaagac ctataatatt
     1441 ttctatccta ctattaaaac aaacaacatt aggctcaaat gaagctttca tacattcact
     1501 tacaaagaaa tcataaacac cagaattctt tcctaaggaa ataaaacttt catttgataa
     1561 ttcagaaata gaaacatact tcctttttga aaggggatga gatttaggaa caattaacac
     1621 aagttcatct tgagctaaag gagtaatatc taagttcgaa taatctaatg tgtcacttct
     1681 taaaaatgca aagtctattt tttgagagaa taataaattt aatatatcag cgtgctctcc
     1741 ttcatggaaa gtaagttgta aatcagtaac tgtattttta aaacttccaa taagttttgc
     1801 aatattatat tgatttatta ctggaatata tccaatagat aatttaggga atgaagaggt
     1861 aaatttattt aaatcaagta ttagttcatc ataattacta actatattta tagcatattt
     1921 ttttaatgaa atacctgcat ctgttaactt aacatggcga gtacatcttt caaaaagtac
     1981 acaattaagt tcactttcta atttttttat atgtttagat aatgaagatt gagatataca
     2041 taattcttca gcagccaaag aaaagctatt atatttttct acacttaaga agtattttaa
     2101 gctttctata ttcataagtt tatcaccgtc atttctgaaa tatattaata ttatatcacg
     2161 ataattatta aggaatggac atatatttcg aatttattcc aaaatggaat aaatgtatat
     2221 taattaaaga attgttcatt aagatagtgt taaatataat ttgagtatat agtagtaact
     2281 ttaaaaaact ttgagaaata gggaaaatta tatgataaaa atagaacgtt gttataaaaa
     2341 tataaatata aaattagagg caatattcgt aggtgatgat ttgtgtgcag tagtaacagg
     2401 aggggataag cctcatgttg gagcaatatc tgtgtattca aaagaagagg gaataaaaac
     2461 aatttctttg aaaaatcata aggattatat tattggagag atttttataa acagtataaa
     2521 agatagtttt aatggaaata tatctgtgag ctgtgggata catatagata atatatcaaa
     2581 agagcagata gaagatgtct atgaatgttg taataaaatt ttccaagaat caaaggtgga
     2641 actttataaa gttactacta atttaaatga ggtggaaaaa tgaatttagt tataggagtt
     2701 actggagcaa ctggcactgt atatgcagtt aggttacttg aatatttaaa agacatagaa
     2761 gaaataaaaa ctcacttaat aatgagtaaa tgggcaatta ataatttaga agttgaaaca
     2821 gattattcat tagattatgt ttatgattta gctgacttta tacataataa tgatgagtta
     2881 ggagcttgtg ttgcgagcgg ttctttttta accgatggaa tgattattct tccttgtagt
     2941 atgaagacac taagcagtat aagtaatgga ttttcaacta cattaataga tagggctgca
     3001 gatgtaatga ttaaggaagg aagaaaatta gttatttcac ctagagaaac acctttaagt
     3061 tcaatacatt tagaaaatat gctaaaactt tcaaagttag gggttagaat agtgccacca
     3121 atgccaggat tttattcaaa tcctaaatct ttagatgata ttataaatca tcatattatg
     3181 aaaatattag atcaatttaa tataaatata agaaatgatt taagatggaa ggtaaatgag
     3241 tatgaataaa gtagaaatta atgatttaag aagtgctatt gaatacttaa aagatattaa
     3301 aggacaatta gttaaaagtg atgttgaagt aaatccacat ggtgaacttg caggggtata
     3361 tagatatgtt ggtgctggag gaactgtaag gagaccaaca aagatagggc cagctatgat
     3421 ttttaataat attaaaggtc ataaagacgc taaagttata atcggtcttt tagctagtag
     3481 agaaagagtt ggtatgcttt taggttgtga atctaaaaag ttaggttttt tattgaatga
     3541 agcagtaaag aatccaataa atccaattat aatagaaaat gaaaatgcac cgtgtcaaga
     3601 ggttgtacat tatgcaacag atgaagattt tgatataaga aaaatattac ctgcacctac
     3661 taatacagaa gaggatgctg gaccatatat aactttagga atgtgttatg caagagatcc
     3721 tgaaactgga gaaggggatg ttacaattca tcgcttatgt ttacaaggta aggatgaatt
     3781 atcaatgttc tttacacctg gggtaagaca tttagatgca tttagaaaaa aggcggagga
     3841 aagtggacaa cctttaccaa tatctattag tataggtgtt gatcctgcaa ttgaaatagc
     3901 atcatgtttt gaaccaccaa ctacaccaat tggatttaat gaattatcta tagctggagc
     3961 aataagaaag aaaccagttg aaatggtaaa atgtttaact gttgatgaag ctgcaattgc
     4021 aagagctgaa tatgtaattg aaggtgagtt agtacctaat aagagagtaa gagaggatat
     4081 gaatacaaac actggaaagg caatgcctga gtttccaggt tacacaggtg aagctgctaa
     4141 agaattacct gtaattagag taaaagctat aactcataga aaaaatccaa taatgcaaac
     4201 ttgtatagga ccaagtgaag agcatgttaa tatggctggg attccaacag aagcaagtat
     4261 aattcaaatg gttgaaaaag caatgccagg tagacttgta aatgtatatg ctcatccagc
     4321 aggtggtgga aaatatatgg ctatattaca aattaaaaag agtatggcta gtgatcaagg
     4381 tagagaaaga caagcggcat tattggcatt atcagcattt tcagaattaa aaactgtaat
     4441 attagttgat gaagatgtag atccatttga tagtaatgat gttttatggg cattaaatac
     4501 tagatatcaa ggggatattg atacaatatt tattccagga gtaagatgtc atcctttaga
     4561 tccttcacaa agtcccgaat atagttggac tattagagat agggggatag cgtgcaaaac
     4621 tatatttgat tgtactgtac cttatgaatt aaaagataaa tttaagagag ctaaatttac
     4681 tgaagtggat ttagagaagt ttaaaataga agattataaa taatagtcaa taagagacat
     4741 caaaataact tttgatgtct ctattaaatt atttaatagg ttcgtagtta attttagatt
     4801 gttcattagt tgattcaatt ttaaaaatta ctgggcgaat accgtcatta caggagcaaa
     4861 ttgctattcc cttttgatct atccaatctt cataataaaa tttgtcacag ccatgagata
     4921 tagcaaaaac atattgatac atagctttcc aagcttcatc acataatcct tcaggttttg
     4981 aataatctcc ataaaatata tctcctactt tatgcatagg acattttcca agattcttgc
     5041 aaccatattg ttttgctaaa tcttcatgga atgttgtttt aagaacttca attttacact
     5101 ttttcataaa attccatctc ctttaactat cttttacgaa tatgagtata tgtggtattt
     5161 tatatttaaa caagtatgca cttttaggta aagtacacac ctttgggtta gtattaaatt
     5221 tttaagaggg tgaaaaaatg agtatgaagg acttggaaaa ttcagattta acagatatta
     5281 agtctactcc ttttggatat acgctttcaa ttataggtgg aaaatggaag atgataataa
     5341 tgttttggtt ggtggagtat gaagtattaa gatatgggga actgaagagg tgtatagggc
     5401 aaataagtga taaaatatta aataatcaat taaaagaatt agagaaggat ggaattatta
     5461 ttagaaaaga atatcctcaa attcccccaa gggtagaata tagactttca aaacgtggtt
     5521 tatctttaat gcccatttta gaagagatgt gtaaatgggg agaagtcaat aaaatttaaa
     5581 tttatttaag taattttagt atttaaagta tataagaata cataatttta actttaggta
     5641 ttcttaaaat aatttttgtt ttgatactat gttatacatc aaaataaata gctaaagata
     5701 aaactactaa taagttttag taatattttt gaatttgaaa gatgtaacta actattaagt
     5761 gtttacatat aatacaagta gaatttagga tattagtagt ttatttaaat aattaatttg
     5821 gtattttagt ttgtgaagct ttatgtatga caataaatat ggggtaaact atatatgggg
     5881 tgtaagagag cgaaaaataa gaaggataaa gagcaaatta agaacatatc taagagcgat
     5941 gaatttcaat tatcattatt aaatctgcaa gtaaagataa ttttaatata tatgatatcc
     6001 aatatatttc ttttcggtgg tacacttcag agtataaata taagttgtaa taaaaaagct
     6061 tcagatagta atcccaatat attattaatt gaagggcaat atttagcctt aattgcaagt
     6121 atattaattt cttatgtaga ttttagcaga tataatgaac taaatgaaag atataaaaaa
     6181 ggagagataa ataagtcatt agaaccagaa gctttaataa agcaagcatc tatacttaca
     6241 atcatactat atgaattgaa tgtagttgta ttcgtggaaa tatataaagt tagtcttgtt
     6301 atagatagtt ctaaatgtga taaaaaacat atagatagat tatatttaca agcagcatgt
     6361 tttataatga ggttttatgg tgactatttt ttgttaagtg ctacattaaa aagtattaat
     6421 ttaataaaaa gcaaatacga taaaagaata gacaaaattg aaaatcctga tgtagatgca
     6481 gtaattgcag cagaaattta tgttatacaa aggggagtac tttatgatat tagttgtaat
     6541 gaattagaag atttaatgaa tagcagtgat gagtttgaaa aggagttatt acttttacct
     6601 aaacaaattt tagtagttgc aaatatattt ggagttgtag caaatataat ttctttaatt
     6661 ggatttatta aattatataa taggaattct aatgaaccta tttttggtag ataaaagtag
     6721 attattttta aggattttta cagatgcatt attagaaggt gcatttttta taatgtaaat
     6781 ctagggatat aaggtataca aagatgtatt atgataaaag tagatatatg tatttttaat
     6841 aataagtata tctactttta ttattttaag actactgata taagagcaaa aaagaatact
     6901 ttatatttga ttataataat ttttagtttg atactatgtt atctatccaa gcaaataatt
     6961 catctaaatc ataatcacct gaatgaggaa ttccccatgg aagatcataa tctacattaa
     7021 ctccattcat ttctaaagtt actgctaaaa tagctgatat tgcaagtgaa gtatcacggt
     7081 caatagcacc atgacgaatt ctgaaatttt tagctgtagt acaagaatta tctgaaatat
     7141 aattcatcgg attcattaat ttaatttgag cttcctcaga taattcacca tttacaattg
     7201 aatgattttt gctaaactca gtaaaatgac gatattgaat ttcgggtgta ccaaataatt
     7261 cgttttcagg tgtacccatt gatatattat caaaagcagg tgtatctttc attctagtac
     7321 ggaactttat aaatttatca aagtctacat cagttacttc gttgtttact atagtaatcc
     7381 acttcaaatc tgataagctc tttcctttat ttaattcttt ttgagctgat ttaataacaa
     7441 aagatttaat ataatcttta aaagttccat ttccttcaga atcaattgtt agtaatgtac
     7501 catttgatga ttttaaattc aatttattta agtattcagg gaataaagat tttaattcct
     7561 tagaaagttc tatttgtaat tcattcattt caccacttat aggtacaagt ttgggttttg
     7621 gagatccttc aattctttca aatttcattt tatgatagtc gtttattcca caaaactccc
     7681 attcgtaggc cttatctgca ttttcaagat ttgtaattgg acaataacaa gatgctgcaa
     7741 aaatatcatc tctttcatca gctgctccca attcttttaa atatgattca tagtcaggat
     7801 ggtttcctgt tgaaccaaga agtgcagata aggctccacc agcactagta ccattagaaa
     7861 ttattttctc tacattacca ggaataatgt ctttattatg acgaaggtaa cgtacagcgg
     7921 cttttaaatc aacaatgcat gctggagcag ttccggtaaa tttaccattt ttatctttta
     7981 atcccctacc acgagcacca ggagaaacta cgatatatcc gtgtaaaagt gcataaaaag
     8041 tagcattggg cttgttaata aatttgttga taccaggctt ttcaggagct cctggcatat
     8101 agccacctac tgtatttggg aagaagattg gtgcagtgtt taaattatag tttcctattg
     8161 aatttccttc ataataagtt tcaggtacaa atatgcttag tttttgaaag ttagtatcta
     8221 ttggattatt aacatatatt atgttttcaa atgcacgata ttttagtgtt ttctcatcta
     8281 aagttattgt ttctatagta tattttttat cattaaattt taaatcgtaa ttcattttat
     8341 ggctcctttc aataatattc ttttatataa ttttaagatt attatgggaa agtaagcaat
     8401 tcaatttgta aaatgtatat attccaatta ggaatatata catttataat aaatttatta
     8461 tctttttaaa ctatcaatta aagagtaagg aattttaagg tcaccttctc caaatccaat
     8521 ttcaatatta cccctattag caccgtgata atcagttcca ccactagaat ataactgata
     8581 cttccatact aaatagtcca aaagtcttct atcatcatca gtataagaag gatagtacct
     8641 ttcaattcca tctaacccta aagaaactaa atatttaata ttatcttcaa tttcttcaaa
     8701 actgaaacct tctaaaccaa ttcttttatt aaagtgagct aaataagact ttccgccagc
     8761 ctcatgaatc attttaatag cttcatctac agtgattaac tcatcatttc cataaggaat
     8821 tggatctaaa tatatatccc aaactttttg aggttcagta caaatattat tttcaagaat
     8881 atatctgtaa atatcatatc tagataaata ttcatcgtat ttcactttat gtaaatagtt
     8941 aatatctata gacaatccat gattgttttc tatatgctta agtatttttg gaacactttt
     9001 ttctcttgct tttttcattt tattatagct atttaaaaag tactcattat gtatatcaat
     9061 tcctaaacca agtatatgaa gtagtctacc atccttatat aatgcactaa tttcaattcc
     9121 attaattaat tcaatattac tatcttctgc agcaatttta gcttctttta aacctgcaat
     9181 actatcatga tcagttaatg aaattgcttt taatttattt ttctttgctg cttttatcac
     9241 atctgttgga ctacagctac catctgaaat atatgaatgt gtgtgtaaat caattaaatt
     9301 ctccataaaa ataccctcca atgatatata ttataacatt ttaataagtt aaatataagt
     9361 tcagagtgca attatagtag tagatcaaat aggtaaaaga tatgtccaaa ttactaaatt
     9421 aatcttataa ttaacttata aggagattag tgattatgag aaaagatata atagataaat
     9481 taatggaatt aacgcaagaa gagaaagaaa tattagaagg aaaacatagc attgatcaaa
     9541 gtatatatac agatgataaa caatttatca tagatagtaa aaaaatattg gcagatggac
     9601 aactcataaa tataagaaaa catacgaggt ttatagagtt ccctgcacat aagcataact
     9661 atattgaatt taattatgtc tataaaggta aacttacgga agtaatacat aataaaaaaa
     9721 tagaacttca agaaggcgaa ataatttttt taaacaaaga tataactcat gcaatagaaa
     9781 aaagttctga ggatgatatt ataattaatt tcataataag accggaattt tttgatttta
     9841 ttcttaactt atcagaaagt gataacatta tatttaactt tttattaaag tcattatatt
     9901 taaataaaaa tagtaaaggt gaatatcttt attttaaagt ttctaatgaa aataatatac
     9961 aagagacttt agaaaagata attatagaaa tttatgaacc cactatgatg agtagcacaa
    10021 ctataaaatt attagttgga ctattaattg tagaattaat taaaaagcct aataatatag
    10081 aagtttattc agaagataat tatgataatt taattataat tgaagtttta aagtatatag
    10141 ataataatta ttctactgca actttatttg aaatatctga aatagtgaat cagccacatt
    10201 ataaaataag taagttagta aaaaagcata ctaatatgac atttaaagaa ttgttacaag
    10261 aaaaaaggct taataaagca aagcaattac taaatgaaac agatatttct attgtagaga
    10321 taatatcttt agttggttat gaaaatctta cttattttta taaaatattt aaagaaaaat
    10381 atggttatac cccaaaagat tttagaaaat cataaattat tgttataagg tgattttact
    10441 atgtatattt atatttgagg aaaaatacat ttgcaaataa ggataataaa ttagacaacc
    10501 ttggttatta aagccaaggt tgtttttatt tataatttaa tcatagtaaa cgttttgcaa
    10561 gggaggagaa atgatgagct attacttagc cattgatatg ggggcttcta gtgggaggca
    10621 tatattagga agtatagaag atggaaagat aaagttagaa gaaatatata gatttgaaaa
    10681 tggaattagc aaaataggag atgaatattg ttgggatatt caaggactct ttaatgaaat
    10741 aaagaaaggt attaaaaagt gcaaagagat tggaaaagtg ccaaaaacca taggcataga
    10801 tacgtgggca gtagattttg ttttattaga tgaaaatgat gagatgctag gaaatgccgt
    10861 tgcctataga gatgatagga ctgagggata tatggaaaaa gcatttcaag ttattccgca
    10921 agatatgttg tatttataca caggaataca attccaaaga tttaatacat tatatcagct
    10981 attagcaatt aaggataaaa atccagaata cttaaaaaag gcaaaaacat ttttaatgat
    11041 tcctgattat ttaaattttt tacttacagg taaaaaagct aatgaatata caaatgcaac
    11101 atctacacag ttagtaaatt cttttgatag aacttgggat aaaaatattt taaaggaata
    11161 tggaatcaat gaggaaatgt tccaagaaat aaaaatgcca aagacaagtt taggaaagtt
    11221 aagaaaagaa ttagttgatg aatttggatt tgatatggag gttatacttc cagcaactca
    11281 tgatactgga tcagcattta tatcttcagt atgtaatgat tcagatagta tttatgtaag
    11341 ttctggtaca tggtcattaa ttggcgtaga gaatagattc ccgatttgtg taccacaagc
    11401 tatggattat aactttacaa atgaaggtgg aattgattat agatttagat ttttaaaaaa
    11461 tattatgggg ctttgggtaa tacaagaggt aaggagaaat ttaaataatg agttttcttt
    11521 tgctgactta gtagtactag ctgaagagca caattatttt aaatcaatag ttaatgttga
    11581 tgatgataga tttttaaaac ccgacaatat gattgaagaa attcaaaact attgtaaaga
    11641 aactaatcaa gatattccaa caaaagttgg agaaatagca gtttgtgtat ttaatagttt
    11701 aggacatagt tacaaaagtg cagtggcaaa tcttgaggat atatttgaaa aagaatttaa
    11761 gagaataaat atatttggag gaggatgcca aaataattta ttaaatcaag tagttgcaga
    11821 tgttactgga aaagaagttt tagcaggacc agtagaggca actgcaatag gaaatcttgt
    11881 agctcaatta ataagtgttg gtgagttaaa ggatttagga caagctaggc aagtaataaa
    11941 agaatcattt gatataaata tatttaaacc aaataaagga gaagtttaag atgaatgtta
    12001 aagaaagata tgaattagct aaagagcaat atgaaaaatg gggaataaat gtagataaag
    12061 ttttagaaga acttaataaa gtgaaaattt cagttcattg ttggcaagga gatgacgtta
    12121 aaggatttga agtagttcaa aatgctttat ctggaggaat tcaatgtaat ggaaattacc
    12181 ctggagcagc aagaagtgca gaagagttaa gagctgattt agataaagca ttaagtttaa
    12241 ttccaggtaa gcataaagta aatttacatg ctatttattt agaaagtaat ggagagtttg
    12301 ttgaaagaga tgaaataaaa ccagaacatt ttgaaaactg ggttaactgg gcaaaagaaa
    12361 gagggctagg attagatttt aatccaacga tattctcaca tccaaaagca gcagatggat
    12421 taacattatc acatccagat aaagaaataa gagatttctg gataagacat gctattgcat
    12481 ctagaaaaat tggtgaatac tttggaaaag aattggggca aacttgctta actaatcttt
    12541 ggattccaga tggatataag gatattccaa gtgatagatt agggccgaga gcaagactta
    12601 aagattcttt agagcaaata tatgcagtta aaacaaataa agattataac ttagattgtg
    12661 ttgaatcaaa agtatttggt ataggtgcag aaagttatac agtaggttca aatgagtttt
    12721 atctaaactt tgcagcaaga aatggaatta tgtcattaat ggatacggga cattatcatc
    12781 caacagaagt tgtttctgat aaattatcat caatgttact atttgatgaa aaggttgctc
    12841 ttcatgtaag tagaccagtt agatgggata gtgatcatgt agttgtttat gatgatgagt
    12901 taaaggaaat tgctaaagaa atagtaagaa atgatgcatt agatagagta attattggac
    12961 ttgatttctt tgatgcaagt attaatagaa tagcagcttg gacaattggt acaagaaata
    13021 tgattaaggc attattaaat gcaatgttaa ctccaaatga attgttaaga aagcttcaag
    13081 atgaaggtaa ctttactgaa agattagcct taatggaaga atttaaaaca tatccaatgg
    13141 gagatatatg gaattactac tgtgaaaaga ataatgtacc agtaggtgaa tcttggatag
    13201 aagatgttaa aagatatgaa gaagaagtgt tatcaaagag aaattaatta taagtaataa
    13261 taaaagaaga gtttatatta ggtatcaaaa taataccata atagagtttt gatatctaat
    13321 atacaaaatt tattgaataa gaggtaatga aaatgagtat gcaagatatg aaatttgtac
    13381 aaaactttat gaaaatgact aatgatgctt ggcttaaagg atggcatgaa agaaatggtg
    13441 gaaatatttc ttatagatta acttctgaaa atgtagaatc aattaagaat attattgatg
    13501 aaaatagaga ttattcacca ataggggtta cagttaaaaa tttagctaat gaatatttct
    13561 tagtaactgg aagtggaaag tttataagaa atgtagctgt tgatttagag gctaatgtag
    13621 gaatagttaa aattgatgaa aaaggtgaaa actataaagt tgtttgggga ttagttaatg
    13681 gtgctaaacc gactagcgaa ttaccatctc atttaatgag tcactctgtt aaattcgaag
    13741 caactaatgg gaagcataga gtgataatgc attcacatgc gacaaattta attgctttaa
    13801 catttgtatt acctcttgat ggagctgtat ttacaagaga attatgggaa atggcaaccg
    13861 aatgtccagt agtattccca tcaggagtag gaatagttcc ttggatggtt ccaggtggag
    13921 ctgaaattgc tgaagcaaca agtgaattaa tgaagaagca tgacgtagtt atttgggcac
    13981 atcatggagt gttctgttca ggtgaggatt tagatttgac atttggactt atggatacag
    14041 ttgagaagtc tgctgaaata cttgtaaaag ttctatcaat gggcggaaag agacaaacta
    14101 taagctcaga taattttaga gatttagcaa gagattttaa tgttactatt tcagaagaat
    14161 atttaaagta attaattaag ttaaggatta aagggtaaag cgaaaagttg aggtaaattg
    14221 tatttttctt aagtatttct gaaactaatg tggtattaaa aatagaaatt caggttttac
    14281 tctttaattt atatattaat aaagaatata cgaaaaattt ataagttata tagaaaaaat
    14341 tagagtaagg agaggatatt atggcaatat attatgtacc atctattaat ttaatgggag
    14401 ctggatgttt aaatgattta ggagcaacag ttaatgattt aggatttaag aaagcttttg
    14461 ttgttactga taatttccta atgagtaatg gagtagcaaa taaagtatta aatgttttag
    14521 agggagcagg aatagcttat gaagtatact cagaagtagt tccaaatcca acttgtaaaa
    14581 atgttcatga tggattagaa agattaaaag gaactgattg tgatttctta gtatcaattg
    14641 gtggaggatc accacaagat acagctaagg ctataggaat cttagcaact aatggtggac
    14701 atattaaaga atatgaagga gtt
//
