LOCUS       c00005_NZ_CABK..       13267 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CABKTV010000005.1 Actinomyces polynesiensis isolate
            MGYG-HGUT-01480, whole genome shotgun sequence.
ACCESSION   c00005_NZ_CABK..
VERSION     c00005_NZ_CABK..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-03-14 01:52:02
            Original ID  :: NZ_CABKTV010000005.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13267
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..765
                     /gene_functions="biosynthetic (rule-based-clusters)
                     histidine2glutamate_hutHGIU_operon: Amidohydro_1"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg5_1"
                     /sec_met_domain="Amidohydro_1 (E-value: 4.2e-32, bitscore:
                     101.2, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="GVRTGPGVRIGAAIHSVRAVPPRDMAIVASWARDRGAPLHVHLSE
                     QVAENEACLEALGATPTAVLDGTGAWEAHATAVHATHLEASDIAVLGAHRVTCCLCPST
                     EADLADGIGPAVELADSGAPLALGSDQNVLTDPFAEMRRLEMDQRLARGTRENFAPVAL
                     VDALTADGHACLGWPESGRIREGALADLVHVSTASAAVAGVRPDRIPLQAGAHDVTDVW
                     VGGRRVVGAGRHVGVEAAPTLARCIAALRSTP"
     protocluster    1..13267
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[0:5809]"
                     /cutoff="10000"
                     /detection_rule="(minimum(3, [Amidohydro_1, Amidohydro_3,
                     Arginase, FGase, Urocanase]) and Lyase_aromatic and
                     Urocanase_C)"
                     /neighbourhood="10000"
                     /product="histidine2glutamate_hutHGIU_operon"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1..5809
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(3, [Amidohydro_1, Amidohydro_3,
                     Arginase, FGase, Urocanase]) and Lyase_aromatic and
                     Urocanase_C)"
                     /neighbourhood="10000"
                     /product="histidine2glutamate_hutHGIU_operon"
                     /protocluster_number="1"
     cand_cluster    1..13267
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(3, [Amidohydro_1, Amidohydro_3,
                     Arginase, FGase, Urocanase]) and Lyase_aromatic and
                     Urocanase_C)"
                     /kind="single"
                     /product="histidine2glutamate_hutHGIU_operon"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13267
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="histidine2glutamate_hutHGIU_operon"
                     /region_number="1"
                     /rules="(minimum(3, [Amidohydro_1, Amidohydro_3, Arginase,
                     FGase, Urocanase]) and Lyase_aromatic and Urocanase_C)"
                     /tool="gutsmash"
     CDS             762..1991
                     /gene_functions="biosynthetic (rule-based-clusters)
                     histidine2glutamate_hutHGIU_operon: Amidohydro_1"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg5_2"
                     /sec_met_domain="Amidohydro_1 (E-value: 3.5e-26, bitscore:
                     81.8, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSTLVTGIAELVTNDPALGRGVLGILHDAALVCEDGRITWVGPA
                     DAAPACDRGIDVHGRAVLPGFVDSHTHLVFDGERSHEFAARMSGEPYTGGGIDRTVHAT
                     RLADDTRLRRGLAARLAELRSQGTTTVEVKGGYGLDVDQEARLLRLAREATTETTFLGG
                     HVIAPEYRTRRAAYVDLVCGEMLEACLPHAKWVDAFCEPASPTALDAEEARAVLEAGAA
                     RGLRPRVHGAQLRQGPGPRLAVEVGAASLDHTTHLGEGDVDLLAEAAHGDGPVVTLLPL
                     VEFSTRQPYPDARRLLDRGITVALASDCNPGTNASSSMPLAMSIAVRDMGMTPQEALWA
                     ATAGGAAALRRDDVGVLRPGARADLAVVDAPTFLHVPYRVGVPLVRALETRTGPPGGPD
                     DTYLSQRPEW"
     CDS             2003..4075
                     /gene_functions="biosynthetic (rule-based-clusters)
                     histidine2glutamate_hutHGIU_operon: Urocanase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     histidine2glutamate_hutHGIU_operon: Urocanase_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Urocanase_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg5_3"
                     /sec_met_domain="Urocanase (E-value: 1.1e-81, bitscore:
                     263.0, seeds: 148, tool: rule-based-clusters)"
                     /sec_met_domain="Urocanase_C (E-value: 1.9e-83, bitscore:
                     268.2, seeds: 88, tool: rule-based-clusters)"
                     /sec_met_domain="Urocanase_N (E-value: 3.9e-53, bitscore:
                     168.1, seeds: 71, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSTRTLHEADHGDVDAATATAGAQPFRVPPISELPPVPPMDPTV
                     RRAPSRGFRLTRAQTRVALANALRYVDPSLHEQLAPEFLDELTRYGRIYGYRFRPAEPL
                     HGRPVDDYEGRCLEGRAFQVMIDNNLDVDVALYPYELVTYGETGSVCHDWMQYRLITSY
                     LKVMTRDQTLVVASGHPVGLFPSRPDAPRVIITNGLMVGLFDNHEDWEIAEEMGVANYG
                     QMTAGGWMYIGPQGIVHGTYNTLLNAGRQYLGIPEDQDLAGRLFVSSGLGGMSGAQPKA
                     MTLAGGVSVIAEVDPSRIATRHSQGWVDRVAVGIPEAFALAEEALGARRALSIAYQGNV
                     VDLLQYAVDHDIPIDLLSDQSSCHDAHYGGYCPQGITFEERTALLGEDPSLFAKLVDES
                     LRTHAGLVRELADRGTYFFDYGNSFLKACFDAGVSDLSRNGTDDKDGFTLPSYVEDIMG
                     PHLFDYGYGPFRWVCLSGSEEDLRATDRAAMESIDPDRRSQDRDNYNWIRDAEDAYLVV
                     GTKARILYQDMEGRCRIALRFNELVREGVIGPVMLGRDHHDVSGTDSPFRETANIRDGS
                     NVMADMAVQCFAGNAARGMSLVALHNGGGVGIGKSINGGFGLVLDGSERVDAVIRSSLL
                     WDVMGGVARRSWARNPHAMEVVADFNRRHGDSAAITEPCLADPGLIESSVDRVLG"
     CDS             4121..5809
                     /gene_functions="biosynthetic (rule-based-clusters)
                     histidine2glutamate_hutHGIU_operon: Lyase_aromatic"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg5_4"
                     /sec_met_domain="Lyase_aromatic (E-value: 3.5e-69,
                     bitscore: 223.1, seeds: 479, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVTRADAVVELGGDADRGDLELADLVRIADGAAVAVPGPVMAALA
                     DAHTRAREIRARGGVYGQSTGVGANKAVAVAADEWRQGMRLLRSHAAGTGPVADARTTR
                     AMLAIRINQLCRAGSGIDPAVVAGMVTMLDTGALPLVRVDSGVGTADLSALATVGLTLA
                     GERPATAPLDPIGAISSDSALPLMSSSALTLAGTLLQVARLEEVLDAAEGAFVLSCTAL
                     RANTSPLAPAAARAVAVPEAQELAHRLRGALRGVRWDPHAVQDSYGFRAYVPSQSVALR
                     AVARLRDQALALCSTAQENPLFTPEGVLHHGVFLQAALAQELSSTCRALAQTTTLTMSR
                     IRMLNDPVHSGLPGFLSTDEAGASGTIILEYVAGSGAAMVLGSVTDLASHSVVISQGME
                     EDASFVGEMLRGLTRAVEGMEVLVACEFLEAVRAATEGREWARGPGRGPVRGRRYPRGG
                     HPRPGPPGGCRHGPGPGHGTGADDATGGRPLGAIGADGTVRVPGRVWPPAECTPGRGAR
                     CRHGERRRHGERRPGGCGPDLLQRRSALLSPAGARRGPGGCRCRG"
     CDS             complement(5757..6365)
                     /locus_tag="ctg5_5"
                     /transl_table=11
                     /translation="MTQAPSWLRRSELAPPPDEGGADTGFSVLFVCTGNICRSAFAEIY
                     LRDRLGPSSPVTVSSAGIMAVAGHDLEDEMAARAQFLGLPRTGHVARQLNGRILAGADL
                     VVVFEEHHLTWVLEERPETLLRTVSLGQAAAAATALGPEGTLPWTELAPRIHALRPSPL
                     PEDWIPDPYGRGPEAASAVAGRITHDIDTLLAHVAPPQG"
     CDS             6611..7759
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_4"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg5_6"
                     /sec_met_domain="Aminotran_4 (E-value: 2.7e-30, bitscore:
                     95.4, seeds: 70, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATQTHVPTALEAAGDVVIPVADELAGRFPLHANPSPASDAEYDA
                     IMEDLTFGRAFTDHMAHMRWTPDQGWHDRAVVPYGPLELTPAAAVLHYSQSVFEGIKAY
                     RHADGSIWTFRPGYNAARIDHSAWRMSLPAIDREDFVASLVDYVRADAKWVPDRPGSSL
                     YLRPFMFASEDFLGVHAAHEIDYYVIGSPSGPYFKGGFEPVSIWVVKGYHRAGPGGTGT
                     AKAGGNYAASLLPQMEAAERGFSQVCFLDTYQEKYLEELGGMNVFVVMADGTVRTPELT
                     GVILEGGTRSAICRMLRSQGTEVREEPIALDELVEGIRSGDVAEVFACGTAAVVTPIGR
                     LAGDDFDVQVPTGPVTEKAYHDLTDIQMGRVPDPFGWTYRIL"
     CDS             complement(7917..8621)
                     /locus_tag="ctg5_7"
                     /transl_table=11
                     /translation="MSDVEQLPGGGVLGAGEDTGTHTEHLEVVVLNGSPSGRSRTASLA
                     QLAADEAAQRFPTHVTHVDVYRIGTDLTSATGREEVGPAAEAALRAVEAADLLVVAVPV
                     FRGSYPGIFKHFVDLLDQYGVAGTPTLLMATGGSDRHSLMVDQELRPLFAFLQAFVAPA
                     GIFVSSAAFDGTAILDPRVYTRVQVALDDLDPLLRVRLAHRARPTGTGPTGPARPTADG
                     PADGTEQAEQVG"
     CDS             complement(8618..9718)
                     /locus_tag="ctg5_8"
                     /transl_table=11
                     /translation="MMEIGVLTFGEVTTDPATGRAPSTRQRVAETLEQARVADQVGLDV
                     FGIGEHHRGDFIASAPQVLLAAAATTTERIRLTSAVTVLSSDDPVRVYEQFATLDQVSG
                     GRAEVMAGRGSYTESFPLFGYSLEDYDTLFEEKLDLLLRIRSTNPISWSGTTRPALDRA
                     DIAPRALQDPLPVWRAVGGSPASAVHAGRAGIPMVIAFLVGPLGAQEVMSQYYRAAAEQ
                     AGVPQDQLRVGASVHGFVGRTSQSARDTMYPHFSRGMRENNHQRGVGFDIPRRAFDAQA
                     GPGGMPVVGSPQEVIDKVMRYHEVYGIDRIMFQMGFGGVPQRDHLEAIELLGTEVAPVL
                     RREFGAGPAAPSGGATALADTGEATR"
     CDS             complement(9715..10176)
                     /locus_tag="ctg5_9"
                     /transl_table=11
                     /translation="MDVVGRRWSGRVVQALGAGCQGFAEIARHVGGVSDQVLARRLREL
                     ESDGLVSRSVTDGHPPLVRYRLTEVGGALLPVLDALTDWGHQLLESTGEGGKPQEEPLG
                     GREILPAWARGGLTTGGTPGAARPPEPDPVAPVGARSTNDQSLRTEQDS"
     CDS             complement(10416..11498)
                     /locus_tag="ctg5_10"
                     /transl_table=11
                     /translation="MAPPTRRVHEPTAPARTSAYRSSGADLPFGHPERAHGVAMEGYYW
                     RVTDPRSGRVLIALIGVQTDATGRWALVGVGNSDGFWREMILPVASARPDGLGARAAGP
                     GTRAAGPGTRVAGTGATFLGTDRRLVVDLGEDARLDLRLDRPTRWPARRPFGGSSWFQS
                     LPGLNQYWHPWLLGGRASGTAEMGGQRRELQGAQLYGEKNWGKAGFPDSWWWGQAQGFA
                     DPSACVAFAGGEVVAGPLHTEVTALVVRLPDGRVLRLGNPVTSPVRAEVDDEHWHLRGR
                     SRGWAVTVDAHAPLGDAHVLPVPLVGQRRAVPGAIEHLSGDLRVRVTRWGEEVWEDRST
                     LAGLEHGGLSRAAALAASRR"
     CDS             11647..13266
                     /locus_tag="ctg5_11"
                     /transl_table=11
                     /translation="MKRLPVIVLSWGSVLGLALVMLCVGRGVDRIIAGRGLGGVELGIA
                     LLGVVASGVCAWGASLLSGRGLAPQERELRHRVLRQVFALGASERTRERTGRIVSTATD
                     GVERAAGYRATFIAPMIASLATPALVLVIVAIAVDPLSAGLLAISIPLVPLCIGSFQMA
                     FRSVSGRYRASSRALAAQELDAIQGLSTLALLNAGSSMGRRLARASEDVRRSVMRLLAG
                     NQLVLLVVDAVFSLAMVTAAVVLALWRIRDGAITPGQGIALVLMSSLMLDPLDRIGQFF
                     YIGMGGIAAGKEIRAFCPEVPDVVDAPGVHWPGDGSHPTDRDAVGGAGESVRLEDVHFS
                     YDGTTPVLDGVDLDLEAGEHLVLTGASGAGKTTIAALVQADLRPDSGRVLIGGHDLREV
                     PLEWTRAQVGTVAQHTYLFTGTLRDNLLLADPSADDQRLLDALRRAHLGDLLDRLSAGL
                     DTPVGERGLGLSGGEAQRVSIARALLKDAPVLVLDEPTAHVDLGSERAVLAAVREATVG
                     RTTLTISHRAATIEDAPARAELR"
ORIGIN
        1 ggcgtccgca ccggtccagg cgtccgcatc ggagcggcca tccactccgt gcgcgccgtc
       61 ccaccccggg acatggcgat cgtcgcctcc tgggcacgtg accggggtgc gcccctgcac
      121 gtgcacctct ccgagcaggt cgccgagaac gaggcgtgcc tggaggccct gggggccacc
      181 cccacagccg tcctcgacgg aaccggggcc tgggaggcgc acgccaccgc cgtgcacgcc
      241 acccacctgg aggccagcga catcgccgtg ctcggcgccc accgcgtcac ctgctgcctg
      301 tgcccctcca ccgaggccga cctcgccgac gggatcggcc cggccgtgga actcgccgac
      361 tccggcgcgc ccctcgccct gggatcggac cagaacgtcc tcaccgaccc cttcgccgag
      421 atgcgccgac tcgagatgga ccagcgcctc gcccgcggca cccgcgagaa cttcgccccg
      481 gtcgccctcg tcgacgccct gaccgcggac gggcacgcct gcctggggtg gccggagtcg
      541 ggacgcatcc gggagggtgc gctcgccgac ctcgtccacg tctccaccgc ctccgccgcc
      601 gtggccgggg tccggcccga ccgcatcccc ctccaggccg gggcccacga cgtcaccgac
      661 gtgtgggtgg ggggacgacg cgtggtgggg gccggacgcc acgtcggggt ggaggccgcc
      721 cccacgctgg cccgctgcat cgcggcactg aggagcaccc catgagcagc acactggtca
      781 ccggcatcgc cgaactcgtc accaacgatc ccgccctcgg acggggagtg ctgggcatcc
      841 tccacgacgc ggcgctggtc tgcgaggacg ggaggatcac ctgggtcggc cccgccgacg
      901 ccgcccccgc ctgcgaccgc ggcatcgacg tgcacgggcg cgcggtgctc cccgggttcg
      961 tcgactccca cacccacctc gtcttcgacg gtgagcgcag ccacgagttc gccgcgcgga
     1021 tgtcggggga gccctacacc ggcgggggca tcgaccgcac cgtgcacgcc acccgcctgg
     1081 ccgacgacac ccgcctgcga cggggactgg cggcgcggct ggcggaactg cgctcccagg
     1141 gcaccaccac cgtcgaggtc aagggtggct acggactcga cgtcgaccag gaggcgcgcc
     1201 tgctgcgtct ggcccgcgag gccacgacgg agacgacctt cctcggcgga cacgtcatcg
     1261 ccccggagta ccgcacgcgg cgcgcggcct acgtcgacct cgtctgcggg gagatgctgg
     1321 aggcctgcct gccccacgcg aagtgggtgg acgccttctg cgaacccgcc tcacccaccg
     1381 ccctggacgc cgaggaggcg cgcgccgtcc tcgaggccgg tgccgcccgc ggactgcgac
     1441 cacgcgtcca cggcgcccag ctgcgccagg gccccggccc ccgcctggcc gtggaggtcg
     1501 gcgcggcgag cctggaccac accacccacc tgggggaggg ggacgtcgac ctcctggcgg
     1561 aggccgcgca cggggacggc ccggtggtca ccctgctgcc cctcgtcgag ttctccaccc
     1621 gccagcccta ccccgatgcg cgccgactcc tggaccgcgg catcaccgtg gccctggcca
     1681 gcgactgcaa cccgggcacc aacgcctcct cctccatgcc actggcgatg tcgatcgcgg
     1741 tgcgcgacat ggggatgacc ccccaggagg ccctgtgggc ggccaccgcc gggggagcgg
     1801 ccgccctgcg acgcgacgac gtcggggtgc tgcgccccgg ggcgcgcgcc gacctggcgg
     1861 tggtggacgc cccgaccttc ctccacgtcc cgtaccgggt gggtgtgccc ctggtgcggg
     1921 ccctggagac ccggaccggc cccccgggcg gccccgacga cacgtacctg tcccagcgac
     1981 ccgaatggtg aggatgagcg agatgaccag cacgaggacc ttgcacgagg cggaccacgg
     2041 ggacgtggac gccgccacgg cgacggcggg cgcccagccc ttccgggtgc caccgatcag
     2101 cgaattgccg cccgtgccac ccatggaccc cacggtgcgc cgcgccccct cgcgcggctt
     2161 ccgcctcacc cgcgcccaga cccgcgtggc cctggccaac gccctgcgct acgtcgatcc
     2221 ctccctgcac gagcagctcg cccccgagtt cctcgacgag ctcacccgct acgggcgcat
     2281 ctacggctac cgcttccggc ccgccgagcc cctgcacggg cgccccgtgg acgactacga
     2341 gggccgctgc ctggagggcc gcgccttcca ggtgatgatc gacaacaacc tcgacgtcga
     2401 cgtcgccctg tacccctatg agctggtcac ctacggggag accgggtccg tgtgccacga
     2461 ctggatgcag taccgcctca tcacctccta cctgaaggtc atgacccgcg accagaccct
     2521 cgtcgtcgcc tccgggcacc ccgtgggact cttcccctcc cgccccgacg ccccgcgcgt
     2581 catcatcacc aacggcctca tggtcggcct cttcgacaac cacgaggact gggagatcgc
     2641 cgaggagatg ggggtcgcca actacgggca gatgacggcg ggcgggtgga tgtacatcgg
     2701 gccccagggc atcgtgcacg gcacctacaa caccctcctc aacgccggac gccagtacct
     2761 gggcatcccc gaggaccagg acctggcggg ccggctcttc gtctcctccg ggctgggcgg
     2821 catgagcggc gcccaaccca aggccatgac cctggcgggg ggcgtgtcgg tcatcgcgga
     2881 ggtcgacccc tcccggatcg cgacccgcca ctcccagggg tgggtcgacc gggtggcggt
     2941 gggcatcccg gaggccttcg ccctggccga ggaggccctc ggggcgcgca gggcgctgtc
     3001 catcgcgtac cagggcaatg tcgtggacct cctccagtac gcggtggacc acgacatccc
     3061 catcgacctg ctctccgacc agtcctcctg ccacgacgcc cactacggcg gctactgccc
     3121 ccagggcatc accttcgagg agcgcacggc cctgctgggg gaggacccga gcctcttcgc
     3181 caagctcgtc gacgagtccc tgcgcaccca tgcgggtctc gtgcgcgagc tcgccgaccg
     3241 cgggacctac ttcttcgact acggaaactc cttcctcaag gcctgcttcg acgccggggt
     3301 gagcgacctg tcccgcaacg gcaccgacga caaggacggg ttcaccctgc cctcctacgt
     3361 ggaggacatc atgggccccc acctcttcga ctacggctac ggccccttcc ggtgggtgtg
     3421 cctgtccggg tccgaggagg acctgcgcgc cacggaccgc gcggccatgg agagcatcga
     3481 cccggaccgg cgctcccagg accgcgacaa ctacaactgg atccgcgacg ccgaggacgc
     3541 ctacctcgtg gtgggcacca aggcccgcat cctctaccag gacatggagg gacgctgccg
     3601 catcgccctg cgcttcaacg aactcgtccg cgagggcgtg atcggtcccg tcatgctcgg
     3661 ccgcgaccac cacgacgtct ccggcacgga ctccccgttc cgcgagaccg ccaacatccg
     3721 cgacggctcc aacgtcatgg ccgacatggc ggtgcagtgc ttcgccggca acgccgcgcg
     3781 cggcatgagc ctggtggccc tgcacaacgg cgggggcgtg ggcatcggca agtccatcaa
     3841 cggtggcttc gggctggtcc tggacgggtc ggagcgggtg gacgccgtca tccgctcctc
     3901 cctcctgtgg gacgtcatgg gcggggtggc caggaggtcg tgggcgcgca acccccatgc
     3961 catggaggtc gtggccgact tcaaccggcg ccacggcgac agcgccgcca tcacggagcc
     4021 ctgcctggct gaccccgggc tcatcgagtc cagcgtcgac cgggtgctcg gctgaggtgg
     4081 ggcgggcggt ggaggacacg gagcggaagg ggagggaccg atggtgacga gggcggacgc
     4141 ggtggtcgag ctgggcggtg acgccgaccg gggcgacctg gagctggcgg acctggtgcg
     4201 catcgcggac ggggcggcgg tggccgtgcc cggaccggtc atggcggcgc tcgcggacgc
     4261 ccacacccgc gcgcgggaga tccgggcccg gggcggcgtg tacggccagt caaccggggt
     4321 gggagccaac aaggccgtgg cggtggcggc cgacgaatgg cgccagggca tgcgcctgct
     4381 tcgcagccac gccgcgggca cgggccccgt ggccgacgct cgcaccacgc gcgccatgct
     4441 cgccatccgc atcaaccagc tgtgccgggc gggatcgggt atcgacccgg ccgtcgtggc
     4501 cgggatggtc accatgcttg acaccggggc cctgcccctc gtgcgggtcg actccggggt
     4561 gggcacggcg gacctgtcgg ccctggccac cgtcgggctc accctggcgg gggagcggcc
     4621 ggccaccgca cccctggatc cgatcggcgc aatctcctcc gactccgcgc tgcccctgat
     4681 gagttcctcc gccctcaccc tggccgggac gctgctgcag gtggcgcgtc tggaggaggt
     4741 gctggacgcc gcggaggggg ccttcgtcct cagctgcacg gccctgcggg ccaacacctc
     4801 cccgctggcg ccggcggcgg cccgtgccgt ggccgtgccc gaggcccagg agctggccca
     4861 ccgcctgcgc ggcgcgctgc ggggagtccg gtgggacccc cacgccgtcc aggactccta
     4921 cggcttccgg gcctacgtgc cctcccagtc cgtggcgctg cgggcagtgg cgcgcctgcg
     4981 cgaccaggcc ctggccctgt gctcgaccgc ccaggagaac ccactgttca cgccggaggg
     5041 ggtcctccac cacggggtgt tcctccaggc cgccctcgcc caggagctgt cctcgacctg
     5101 ccgggccctg gcccagacga ccacgctcac gatgtcccgg atccgcatgc tcaacgaccc
     5161 ggtccactcc gggctgcccg gtttcctctc caccgacgag gcaggcgcct cgggcacgat
     5221 catcctcgag tacgtcgccg gatccggggc ggccatggtg ctggggtcgg tcaccgacct
     5281 ggcctcccac tccgtcgtca tctcccaggg catggaggag gacgcctcct tcgtggggga
     5341 gatgctccgg gggctcaccc gcgcggtgga gggcatggag gtcctcgtcg cctgcgagtt
     5401 cctggaggcc gtgcgcgctg cgactgaggg gcgggagtgg gcacgagggc ccggtcgggg
     5461 acctgttcgc ggtcggcgat accctcgggg aggacacccg cgaccgggac ctccaggagg
     5521 atgtcgacac ggcccgggcc ctggtcacgg cactggggcg gacgatgcga cgggtggccg
     5581 tcccctcggc gccatcggag ccgacggcac cgtgagggtc cccggccggg tgtggccacc
     5641 cgcagagtgc acgccaggac gcggtgcgcg ctgccgacac ggtgagcgtc gtcggcacgg
     5701 tgagcgtcgc ccgggtgggt gtggaccaga cctcctccag cgccgctcag ccctgctcag
     5761 ccctgcgggg gcgcgacgtg ggccaggagg gtgtcgatgt cgtgggtgat gcgcccggcg
     5821 acggcggacg ccgcctcggg gccacggccg tagggatcgg ggatccagtc ctcgggcagg
     5881 ggggagggcc gcagggcgtg gatgcgcggc gcgagttcgg tccaggggag cgtcccctcc
     5941 ggcccgagag ccgtggcggc ggccgctgcc tggcccaggg acaccgtgcg caggagcgtc
     6001 tcggggcgct cctcgaggac ccaggtgagg tggtgctcct cgaagacgac caccaggtcc
     6061 gcccccgcca ggatgcgtcc gttcagctgg cgtgccacgt gcccggtgcg ggggaggccg
     6121 aggaactgcg cgcgggccgc catctcgtcc tccaggtcat ggccggccac cgccatgatg
     6181 ccggcggagg agaccgtgac ggggctggag gggcccaacc ggtcgcgcag gtagatctcg
     6241 gcgaacgccg agcggcagat gttcccggtg cacacgaaga gcaccgagaa gccggtgtcc
     6301 gccccgccct cgtccggggg aggtgccagc tccgacctcc tcagccacga cggcgcctgg
     6361 gtcatcgctg cctccctccc acgtccggac ctccatcttc gtgcatcgga gtcgcgcgtg
     6421 gacagtgccc ggacgcgagc cgcgatcggg tgggacccag gtcccgggtt ctgggcgcag
     6481 tgccgacgag ggcgcctccg cgagccctcc cgggctccgg agtcaggtca catgacggac
     6541 ccggacccgc gaaatggtgc ggattcccta ggctggtgcg cgacatcacg tccagaagag
     6601 gaggccccgg atggcaaccc agacacacgt ccccaccgcg ctcgaagcag caggtgacgt
     6661 cgtcatccct gtagccgacg agctggccgg gcggttcccg ctgcacgcca acccgagccc
     6721 cgcctccgat gccgagtacg acgccatcat ggaggacctc accttcgggc gtgccttcac
     6781 cgaccacatg gcccacatgc ggtggacgcc ggaccagggc tggcacgacc gcgcggtcgt
     6841 cccctacggg ccgctggagc tgacgcccgc cgctgcggtg ctccactact cccagtcggt
     6901 gttcgagggc atcaaggcct accggcacgc ggacgggtcc atctggacgt tccgtcccgg
     6961 ctacaacgcc gcccgcatcg accactcggc ctggcgcatg tccctgcccg cgatcgaccg
     7021 tgaggacttc gtcgcctccc tggtcgacta cgtgcgggcc gacgccaagt gggtgccgga
     7081 caggcccggg tcgagcctgt acctgcggcc cttcatgttc gcctcggagg acttcctcgg
     7141 cgtgcacgcc gcccacgaga tcgactacta cgtcatcggc tccccctcgg gtccctactt
     7201 caagggcggc ttcgagccgg tgtccatctg ggtcgtcaag ggctaccacc gggccggccc
     7261 cggcgggacc ggtaccgcga aggccggcgg caactacgct gcctcgctcc tgccccagat
     7321 ggaggccgcc gagcgcggtt tctcccaggt gtgcttcctc gacacctacc aggagaagta
     7381 cctcgaggaa ctcggcggca tgaacgtctt cgtcgtcatg gccgacggga ccgtgcgcac
     7441 ccccgagctg accggcgtca tcctcgaggg cggcacccgc tccgcgatct gccgcatgct
     7501 gcgctcccag ggcactgagg tccgtgagga acccatcgcc ctggacgaac tggtcgaggg
     7561 catccggtcc ggcgacgtcg ccgaggtctt cgcctgcggc acggccgcgg tcgtgacccc
     7621 catcggccgc ctcgccgggg acgacttcga cgtgcaggtg cccaccgggc ccgtcaccga
     7681 gaaggcctac cacgacctga ccgacatcca gatggggcgc gtccccgatc ccttcggttg
     7741 gacctaccgc atcctctgag gccatctgcg tcgggggagc ggtgaggggc ccggagccac
     7801 acggctccgg gccccctccg tgtccggcac acggggtcgg tgggcagggg atggagggcg
     7861 cgtgatcccg gagaccgcgc ccctccgcgt ccccggccgt cagcggtggc gggggactac
     7921 ccgacctgtt cggcctgctc ggtgccgtcc gccggcccgt ccgcggtcgg tcgggcgggc
     7981 ccggtcggtc ctgttcccgt cgggcgcgcc cggtgggcca ggcggacccg gagcaggggg
     8041 tcgaggtcgt cgagggcgac ctggacccgc gtgtagacgc gcgggtccag gatggccgtc
     8101 ccgtcgaacg cggctgagct gacgaagatg ccggccggcg ccacgaaggc ctggaggaac
     8161 gcgaagaggg ggcgcagctc ctggtcgacc atgagggaat gacggtcgga tccgcccgtg
     8221 gccatgagca gcgtcggggt gcccgccacg ccgtactggt ccaggaggtc cacgaagtgc
     8281 ttgaagatcc ccgggtagga accccggaac acgggcacgg ccaccaccag caggtcagcc
     8341 gcctcgacgg ctcgcaacgc cgcctcggca gcggggccca cctcctcgcg tccggtggcg
     8401 gaggtcaggt cggtcccgat ccggtacacg tcgacgtggg tgacgtgggt ggggaagcgc
     8461 tgtgccgcct cgtcagcggc gagctgtgcc agtgaggccg tcctggacct ccccgagggg
     8521 gatccgttga ggaccacgac ctcgaggtgc tccgtgtggg tgcccgtgtc ctctcccgcg
     8581 ccgaggacgc ctccgcccgg gagctgctcc acgtcgctca tcgggtggcc tccccggtgt
     8641 ccgcgagggc ggtcgcaccg ccggacggtg ctgcgggacc cgcaccgaac tcgcgacgca
     8701 ggacgggcgc gacctcggtt cccagcagct cgatggcctc caggtggtcg cgctggggga
     8761 ctccaccgaa gcccatctgg aacatgatgc ggtcgatgcc gtagacctcg tggtagcgca
     8821 tgaccttgtc gatgacctcc tggggtgagc ccaccaccgg catgcccccg ggccccgcct
     8881 gggcgtcgaa ggcccggcgc gggatgtcga acccgacacc gcgctggtgg ttgttctcac
     8941 gcatgccgcg cgagaagtgg gggtacatgg tgtcccgggc ggactgactg gtgcgcccca
     9001 cgaagccgtg cacgctggcg cccacgcgca gctggtcctg gggcacgccc gcctgctcgg
     9061 cggcggcccg gtagtactgg gacatgacct cctgggcgcc cagtggaccc accaggaagg
     9121 cgatgaccat cgggatgccc gcccgtccag cgtggacggc ggaggcgggt gacccaccca
     9181 ccgcccgcca cacgggcagg gggtcctgga gggcgcgagg agcgatgtcg gcacggtcca
     9241 gggcaggtcg ggtagtgccg gaccaggaga tcgggttggt ggagcggatc cgcaggagga
     9301 ggtcgagctt ctcctcgaag agggtgtcgt agtcctccag ggagtacccg aacaggggga
     9361 aggactccgt gtaggagccg cgtcccgcca tcacctccgc gcgtcccccg gagacctggt
     9421 ccagggtggc gaactgctcg tagacgcgca cggggtcatc gctggacagg accgtgacgg
     9481 cgctggtcag gcggatgcgt tcggtggtcg tggccgctgc ggccaggagc acctgggggg
     9541 cggaggcgat gaagtccccg cggtggtgct ccccgatgcc gaagacgtcc aggcccacct
     9601 ggtccgccac cctcgcctgc tccagggtct ccgcgacacg ctggcgggtg ctgggcgccc
     9661 gcccagtggc cgggtccgtg gtgacctcac cgaatgtgag gactccgatc tccatcatga
     9721 atcctgctcc gtccgaagtg actggtcgtt cgtgctgcgt gcccccaccg gggcgacggg
     9781 gtccggctcg ggtggtcgtg cggcgcccgg cgtccctccg gtggtgaggc cgccccgggc
     9841 ccacgcgggg aggatctcgc gcccaccgag gggttcctcc tgcggtttgc cgccttctcc
     9901 cgtggactcg aggagttggt ggccccagtc cgtgagggcg tccaggacgg ggagcagtgc
     9961 gcctccgacc tccgtcagcc ggtaccggac cagtggggga tgcccgtcgg tgacggaacg
    10021 gctgacgagc ccgtcggact cgagctcgcg gaggcggcgg gccaggacct ggtccgagac
    10081 gcctcccaca tggcgggcga tctccgcgaa cccctggcag ccggccccca gtgcctggac
    10141 cacgcgaccg ctccagcggc ggccgacgac gtccatcgcc gccacgaagg agggacaggc
    10201 gctgcccgca tcccctgcgg gcggccggga ggggtgcgtc gactcttctg tactcacaaa
    10261 aggtgagtat ctaccgaaat gagagtgtcc acaacaggga tgggtgtgat ccgcgcaatg
    10321 gcagtgaggc ggtggaggag ctggtggtgg gggagccggg gagggtgtgg ttgcggcgcg
    10381 tgggtgacgg tgacggggcc ctgaccggcg tcggttcacc tgcgcgaggc cgccagggcc
    10441 gcggcgcggg acaggccgcc gtgctccagg ccggccaggg tggaccggtc ctcccacacc
    10501 tcctcgcccc agcgggtgac ccgcacccgc aggtccccac tgaggtgctc gatggcaccg
    10561 gggacggcgc gacgctgccc gaccaacggg acggggagga catgggcatc gcccagcggt
    10621 gcatgtgcgt cgaccgtgac cgcccagccg cgtgaacggc cacgcaggtg ccagtgctcg
    10681 tcatcgacct ccgcccgcac gggtgaggtc acggggttgc ccagacgcag cacgcggccg
    10741 tcgggcaggc gcaccacgag tgcggtgacc tcggtgtgca gcggacccgc caccacctca
    10801 cccccggcga atgccacgca ggccgacggg tcggcgaagc cctgggcctg cccccaccac
    10861 caggagtcgg ggaaccccgc cttcccccag ttcttctccc cgtagagctg ggcaccttgg
    10921 agttcccgac gctgtccgcc catctcggca gttcccgagg cacgcccacc gaggagccag
    10981 ggatgccagt actggttgag gccgggcagc gactggaacc agctcgaccc accgaagggt
    11041 cgtcgggccg gccagcgcgt gggacggtcg agacggaggt cgagacgggc atcctcgccc
    11101 aggtcgacca ccagacgtcg gtccgtgccg aggaaggtcg cccccgtccc tgcgacgcgt
    11161 gtcccaggcc ccgcggcgcg tgttccgggc cctgcggcac gggcaccgag tccgtcgggc
    11221 cgggcgctgg ccacgggcag gatcatctcg cgccagaagc cgtcggagtt ccccactccc
    11281 accagcgccc accgacccgt cgcgtcggtc tggaccccga tgagggcgat gaggacacgc
    11341 ccggaccgcg ggtccgtcac gcgccagtag tagccctcca tggcgacgcc gtgggcccgc
    11401 tcggggtgcc cgaaggggag gtcggcgccc gaggaccgat aggccgacgt acgggcaggt
    11461 gcggtcggct cgtgcacacg gcgcgtggga ggtgccatgt ccgcgatcct cgcacggggc
    11521 ggtgcccggc gcccggcgtt ggggcgtgca tcctcccccg tggcagccgc gtcgccctcg
    11581 tcctcgaccc tccccggagc gggacgtagg gtgggcctga tgttcgccgg acgaggatgg
    11641 gaccgcatga agaggcttcc ggtcatcgtg ctgtcatggg gatcggtcct cggactggcg
    11701 ctggtcatgc tctgcgtcgg acgcggggtg gaccgcatca tcgccggccg gggactcggg
    11761 ggcgtggaac tcgggatcgc cctcctcggg gtggtcgcct ccggggtgtg cgcgtggggg
    11821 gcctccctcc tctccgggag ggggctcgct ccccaggaga gggagctgcg gcaccgcgtg
    11881 ctgcgacagg tcttcgccct gggcgcgtct gagcgcaccc gggaacgcac cggccgcatc
    11941 gtgtccaccg ccaccgacgg ggtcgagcgc gcagccgggt accgggcgac gttcatcgcc
    12001 ccgatgatcg cctcactggc cacacccgcc ctcgtcctcg tcatcgtcgc gatcgccgtc
    12061 gaccccctca gtgcaggcct gctcgccatc tccatccccc tggtccccct gtgcatcggg
    12121 tccttccaga tggccttccg gagcgtctcc gggcggtacc gcgcctcctc ccgggcgctc
    12181 gcggcgcagg aactggacgc catccagggc ctgtcgaccc tggcactcct caacgccggg
    12241 agctccatgg ggcgccgcct ggcgcgggcg agcgaggacg tgcgccgcag cgtcatgcgg
    12301 ctcctcgccg gcaaccagct cgtgctcctg gtggtcgacg ccgtcttctc cctggccatg
    12361 gtcaccgccg ccgtggtcct ggccctgtgg cggatccgcg acggggcgat cacgccggga
    12421 cagggcatcg ccttggtcct gatgtcctcc ctgatgctcg accccctgga ccgcatcggg
    12481 cagttcttct acatcgggat gggagggatc gcggccggga aggagatccg cgcgttctgc
    12541 ccggaggtgc ccgacgtcgt cgacgccccc ggcgtgcact ggccgggcga tgggtctcac
    12601 ccgacggatc gggacgccgt gggcggcgcc ggtgaatccg tgcgcctgga ggacgtgcac
    12661 ttcagctacg acggcacgac acccgtgctg gacggcgtgg acctcgacct cgaggccggt
    12721 gagcacctgg tgctcaccgg tgcctccggg gcgggcaaga ccaccatcgc cgccctcgtc
    12781 caggccgacc tgcgtcccga ctccgggcgg gtgctgatcg ggggccacga cctgcgcgag
    12841 gtccccctgg agtggacgcg cgcgcaggtc ggcaccgtcg cgcagcacac ctacctgttc
    12901 accggcaccc tccgcgacaa cctcctcctg gccgatccct ccgccgatga ccagcgcctg
    12961 ctcgacgccc tgcggcgcgc ccacctcggt gacctcctgg accgcctgtc ggccggactg
    13021 gacacacccg tgggggagcg gggcctgggg ctctcgggag gggaggcgca gcgtgtctcc
    13081 atcgcccggg cgctcctcaa ggacgcgccg gtgctggtcc tcgacgaacc caccgcccac
    13141 gtggacctcg gctccgagcg ggccgtcctc gccgccgtgc gggaggcgac ggtcgggcgc
    13201 acgaccctga cgatctccca ccgcgccgcc accatcgagg acgcccccgc acgcgcggag
    13261 ctgcgcg
//
