LOCUS       NZ_CP020549.1          23244 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP020549.1 Streptococcus pneumoniae strain Hu17 chromosome.
ACCESSION   NZ_CP020549
VERSION     NZ_CP020549.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-03-13 23:20:54
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 886050
            Orig. end    :: 909294
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..23244
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="[896050:899294]"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..13244
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
     cand_cluster    1..23244
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /kind="single"
                     /product="Putrescine2spermidine"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..23244
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="Putrescine2spermidine"
                     /region_number="2"
                     /rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /tool="gutsmash"
     CDS             1536..1985
                     /locus_tag="ctg1_874"
                     /transl_table=11
                     /translation="MKLTDYVKQVSLEDFGRAFIHHVQWNRRLRSTGGRFFPKDGHLDF
                     NPKVYQKLGMEVFRKIVRHELCHYHLYFQGKGYQHKDRDFKELLKAVDGLRFVPSLPNS
                     NSKPLKLYRCQSCQQRYQRKRRIDTKRYRCGLCRGKLLLINQPED"
     CDS             2044..2316
                     /locus_tag="ctg1_875"
                     /transl_table=11
                     /translation="MNSKFYKMRRNRMISGVLAGLSDKWNFDVTLVRFLFAIFTVANFG
                     LGVIIYIILASIMPTKEEIEAEMYGTGPRKRKEAQAIDDNEGWFW"
     CDS             complement(2670..2861)
                     /locus_tag="ctg1_876"
                     /transl_table=11
                     /translation="MKHKEHILIGLLYLLSPFIGQLLVEHTHFIGTEFTGTAYVICWLS
                     VVISIHHFSKNILSQQQK"
     CDS             3164..3274
                     /locus_tag="ctg1_877"
                     /transl_table=11
                     /translation="MKQILHKKTRKPSHKEIERVQLGCTMMQATFHLMGY"
     CDS             3289..4047
                     /locus_tag="ctg1_878"
                     /transl_table=11
                     /translation="MTLLDVKHVQKIYKTRFQGNQVEALKDIHFTVEKGDYVAIMGESG
                     SGKSTLLNILAMLDKPSRGQVYLNGTDTATIKNSQASSFRREKLGFVFQDFNLLDTLSV
                     KDNILLPLVLSRRPITEMMKKLVVTAENLGINQLQEKYPYEISGGQKQRVAVARAIITE
                     PEILLADEPTGALDSKSSAALLDVFDEINERGQTILMVTHSTAAASRAKRVLFIKDGIL
                     YNQIYRGEKTERQMFQEISDTLTVMASEVN"
     CDS             4049..6037
                     /locus_tag="ctg1_879"
                     /transl_table=11
                     /translation="MFRLTNKLAVSNLIKNRKLYYPFALAVLLAVTVTYLFYSLTFNPK
                     IAEIRGGTTIQATLGFGMFVVTLASAIIVFYANSFVMKNRSKELGIYGMLGLEKRHLIS
                     MTFKELVVFGILTVGAGIGIGALFDKLIFAFLLKLMKLKVELVATFQTKVVITVLVVFG
                     LIFLGLMFLNALRIARMNALQLSREKASGEKKGRFLPLQTILGSISLGIGYYLALTVKD
                     PLTALTTFFIAVLLVIFGTYLLFNAGITVFLQILKKNKKYYYQPNNLISVSNLIFRMKK
                     NAVGLATIAILSTMVLVTMSAATSIFNSSESFKKVLNPHDFGVSGQNVEKEDLDKLLSQ
                     FASDKGYKIKEKEVFRYTYFAVANQEGTELTIFEKGQNRVQPKTIFMVFDQKDYENMTG
                     QKLSLSGNEVGLFAKNEGVKEQKTLILNDHQFSVKEEFNKDFIVKHVPNQFNILTADYN
                     YLVVPDLQAFLNQFPDSAIYNQFYGGMNVNVSEEEQLKVAEEYEKYLQKFNAQLNTEGN
                     YVYGSTLADASAQMSVLFGGVFFIGIFLSIIFMVGTVLVIYYKQISEGYEDRERFIILQ
                     KVGLDQKQIKQTINKQVLTVFFLPLLFAFLHLAFAYHMLSLILKVIGVLDTTMMLIVTL
                     SICAIFLIAYVLIFMITSRSYRKIVQM"
     CDS             complement(6079..6996)
                     /locus_tag="ctg1_880"
                     /transl_table=11
                     /translation="MQENYTTKAKHLTIDSRRLIERWKKEGKSNREIASLLGKAPXXXX
                     XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXSETNHEIDSNFAGRLNILRAGVLGANDGI
                     ISIAGVVIGVASATTNIWIIFLSGFAAILAGAFSMAGGEYVSVSTPKDTEEAAVSREKL
                     LLDQDRELAKKSLYAAYIQNGECKTSAQLLTNKIFLKNPLKALVEEKYGIEYEEFTNPW
                     HAAISSFVAFFLRSLPPMLSVTIFPSDYRIPATVLIVGVALLLTGYTSARLGKAPTKTA
                     MIRNLAIGLLTMGVTFLLGQLFSI"
     CDS             7703..9178
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_7_arginine"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_881"
                     /sec_met_domain="OKR_DC_1_C (E-value: 4e-11, bitscore:
                     40.3, seeds: 113, tool: rule-based-clusters)"
                     /sec_met_domain="OKR_DC_1_7_arginine (E-value: 4e-125,
                     bitscore: 414.5, seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LKELDQNQAPIYEALVKLRKKRIVPFDVPGHKRGRGNPELVELLG
                     EKCVGIDVNSMKPLDNLGHPISIIRDAEELAADAFGASHAFLMIGGTTSSVQTMILATC
                     KAGDKIILPRNVHKSAINALVLCGAIPIYIEMSVDPKIGIALGLENDRVAQAIKDHPDA
                     KAILINNPTYYGICSDLKGLTEMAHEAGMMVLVDEAHGAHLHFTGKLPISAMDAGADMA
                     AVSMHKSGGSLTQSSLLLIGEQMNPEYVRQIINLTQSTSASYLLMASLDISRRNLALRG
                     KESFEEVIELSEYARHEINAIGGYYAYSKELIDGVSVCDFDVTKLSVYTQGIGLTGIEV
                     YDLLRDEYDIQIEFGDIGNILAYISIGDRIQDIERLVGALADIKRLYSRDGKDLIAGEY
                     IQPELVLSPQEAFYSERKSLTLDESVGQVCGEFVMCYPPGIPILAPGERITREIVDYIQ
                     FAKERGCSLQGTEDPEVNHINVIKRKTNYKKSQ"
     CDS             9357..9920
                     /locus_tag="ctg1_882"
                     /transl_table=11
                     /translation="MLSNDFIQLRKDDIKTTSVLXXXXXXXXXXXXXXXXXXXXXXXXX
                     XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
                     XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
                     XXXXXXXXXXXXLSEIVKRLEEMN"
     CDS             10001..10861
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synth"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synt_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_883"
                     /sec_met_domain="Spermine_synth (E-value: 2e-49, bitscore:
                     164.6, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Spermine_synt_N (E-value: 1.7e-15,
                     bitscore: 53.6, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLWFSEVHTPDVKLSLRTAKQLYAGKSEWQDIEVLDTPAFGKIL
                     ILNGHVLFSDADDFVYNEMTVHVPMAVHPNPKKVLVIGGGDGGVAQVLTLYPELEQIDI
                     VEPDEMLVEVCREYFPDFAAGLDDPRVTIYYQNGLRFLRNCEDDYDIIINDATDPFGHT
                     EGLFTKEFYGNSYRALKEDGIMIYQHGSPFFDEDESACRSMHRKVNQSFPISRVYQAHI
                     PTSPAGYWLFGFASKKYHPVKDFDKEGWKKRQLFTEYYTANLHVGSFMLPKYVEDILEE
                     EEGKK"
     CDS             10858..12117
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Sacchrp_dh_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Sacchrp_dh_NADP"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_884"
                     /sec_met_domain="Sacchrp_dh_C (E-value: 1.7e-41, bitscore:
                     140.0, seeds: 375, tool: rule-based-clusters)"
                     /sec_met_domain="Sacchrp_dh_NADP (E-value: 1.1e-30,
                     bitscore: 103.5, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRLLVIGCGGVAQVAISKICQDSETFTEIMIASRTKSKCDDLKA
                     KLEGKTSTKIETAALDADKVEEVIALIESYKPEAVLNVALPYQDLTIMDACLATGVHYI
                     DTANYEAEDTEDPEWRAIYEKRCKELGFTAYFDYSWQWAYQEKFKEAGLTALLGSGFDP
                     GVTSVFSAYALKHYFDEIHYIDILDCNGGDHGYPFATNFNPEINLREVSAPGSYWEDGK
                     WVEVEAMSIKREYDFPQVGQKDMYLLHHEEIESLAKNIPGVKRIRFFMTFGQSYLTHMK
                     CLENVGLLRTDTINFNGQEIVPIQFLKALLPDPASLGPRTVGKTNIGCIFTGVKDGVEK
                     TIYIYNVCDHQECYAEVGSQAISYTTGVPAMIGTKLVMNGTWKQAGVYNLEELDPDPFM
                     EALNEYGLPWVVVENLQMVD"
     CDS             12117..13244
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Orn_DAP_Arg_deC"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_885"
                     /sec_met_domain="Orn_DAP_Arg_deC (E-value: 2.4e-13,
                     bitscore: 47.1, seeds: 500, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLEQVPTPAYVIDLAKLEANCRILQYVQEEVGCKVLLAQKAYSL
                     YKTYPLISQYLSGTTASGLYEAKLAREEFPGEVHVFAPAFKDADLEELLGITDHIVFNS
                     ERQLRKHGARCREAGVSVGLRLNPQCSTQGDHALYDPCAPGSRFGVTIDKIPSDLLDLV
                     DGLHFHTLCEQGADDLQTTLKAVEEQFGPYLHEVKWLNMGGGHHITREGYDVDLLISEI
                     KRIRKTYNLEIYIEPGEAIALNAGYLATEVLDIVENGMEILVLDASATCHMPDVLEMPY
                     RPPLRNGFEAQEKAHTYRLSSNTCLTGDVIGDYSFENPVQIGDRLYFQDMAIYSFVKNN
                     TFNGIGLPSLYLMDEQGDCSLLKAFGYQDFKGRLS"
     CDS             13241..14326
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PAD_porph"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_886"
                     /sec_met_domain="PAD_porph (E-value: 2.2e-122, bitscore:
                     405.3, seeds: 436, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMDSPKKLGYHMPAEYEPHHGTLMIWPTRPGSWPFQGKDAKRAFT
                     QIIETIAEGERVYLLVEQAYLSEAQSYLGDKVVYLDIPTNDAWARDTGPTILVNDKGKK
                     LAVDWAFNAWGGTYDGLYQDYEEDDQVASRFAEALERPVYDAKPFVLEGGAIHSDGQGT
                     ILVTESCLLSPGRNPNLTKEEIENTLLESLGAEKVIWLPYGIYQDETNEHVDNVAAFVG
                     PAEVVLAWTDDENDPQYAMSKADLELLEQETDAKGCHFTIHKLPIPAVRQVVTEEDLPG
                     YIYEEGEEERYAGERLAASYVNFYIANKAVLVPQFEDVNDQVALDILSKCFPDRKVVGI
                     PARDILLGGGNIHCITQQIPE"
     CDS             14336..15211
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CN_hydrolase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_887"
                     /sec_met_domain="CN_hydrolase (E-value: 1.8e-51, bitscore:
                     172.0, seeds: 52, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRNVRVATIQMQCAKDVATNIQTAERLVRQAAEQGAQIILLPELF
                     EHPYFCQERQYDYYQYAQSVAENTAIQHFKVIAKELQVVLPISFYEKDGNVLYNSIAVI
                     DADGEVLGVYRKTHIPDDHYYQEKFYFTPGNTGFKVWNTRYAKIGIGICWDQWFPETAR
                     CLALNGAELLFYPTAIGSEPILDTDSCGHWQRTMQGHAAANIVPVIAANRYGLEEVTPS
                     EENGGQSSSLDFYGSSFMTDETGAILERAERQEEAVLLATYDLDKGASERLNWGLFRDR
                     RPEMYRQITD"
     CDS             complement(15391..16200)
                     /locus_tag="ctg1_888"
                     /transl_table=11
                     /translation="MIKLLALDMDGTLLNEAKEIPQAHIAAIHQAIEKGVKLVLCTGRP
                     LFGVLPYYKKLGLDLQNEYVIVNNGCSTHQTSDWGLVDWQELSPADIEYLYDLAEKSDV
                     QLTLFDESHYFVLGGKPNQVIENDAKLVFSDLTEISLEEATSGKFRMFQGMFLGTKEQT
                     DDFEQRFAEELCQRFSGVRSQPVIYEAMPLGTTKATALSRLAEILKIDSSEIMAMGDAN
                     NDIEMLQFAGLGIAMGNASDYVKSLADAVTSSNEEDGVARAIEKYIL"
     CDS             16472..16693
                     /locus_tag="ctg1_889"
                     /transl_table=11
                     /translation="MILMTKNINLTNEELELIQGGADPYGKEPNGYYPWQMEPVLTMPV
                     HGFCPRGTDDLVYIVGGNHLCKGSAARF"
     CDS             16747..17418
                     /locus_tag="ctg1_890"
                     /transl_table=11
                     /translation="MKKRAIQILLALSLIFYKSTWFWRLFNYLAKPYLPASREFFQILL
                     LLESGVLLSAVIYLLVFAGKKIFHFKWQLRYFIYLLLGYIISYMSDFLFSYFISPPSNQ
                     ISLNETIEMMGRQEFPYFLLIVCFIAPIAEELIYRGVIMTTFFKNSPWYGDVLLSAIIF
                     GYIHINFALTPLAFFIYASGGLILALLYRMTKNLYYPILVHILINITAFWDVWLLLFSG
                     S"
     CDS             17660..18568
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HTH_1"
                     /gene_functions="regulatory (smcogs) SMCOG1012:Bacterial
                     regulatory helix-turn-helix protein, lysR family (Score:
                     -3.8; E-value: 46)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_891"
                     /sec_met_domain="LysR_substrate (E-value: 6.7e-13,
                     bitscore: 45.5, seeds: 361, tool: rule-based-clusters)"
                     /sec_met_domain="HTH_1 (E-value: 8.5e-18, bitscore: 61.1,
                     seeds: 1330, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIQQLRYVVAIANSGTFREAAEKMYVSQPSLSISVRDLEKELGF
                     KIFRRTSSGTFLTRRGMEFYEKAQELVKGFDIFQNQYANPEEEKDEFSVASQHYDFLPP
                     TITAFSERYPDYKNFRIFESTTVQILDEVAQGHSEIGIIYLNNQNKKGIMQRVEKLGLE
                     VIELIPFHTHIYLCEGHPLAQKEELVMEDLADLPTVRFTQEKDEYLYYSENFVDTSASS
                     QMFNVTDRATLNGILERTDAYATGSGFLDSDSVNGITVIRLKDNLDNRMVYVKREEVEL
                     SQAGTLFVEVMQEYFDQKRKS"
     CDS             18565..19026
                     /locus_tag="ctg1_892"
                     /transl_table=11
                     /translation="MKKRAIVAVIVLLLIGLDQLVKSYIVQQIPLGEVRSWIPNFVSLT
                     YLQNRGAAFSILQDQQLLFAVITLVVVIGAIWYLHKHMEDSFWMVLGLTLIIAGGLGNF
                     IDRVSQGFVVDMFHLDFINFAIFNVADSYLTVGVIILLIAMLKEEINGN"
     CDS             19016..19903
                     /locus_tag="ctg1_893"
                     /transl_table=11
                     /translation="MEIKIETGGLRLDKALSDLSELSRSLANEQIKSGQVLVNGQVKKA
                     KYTVQEGDVVTYHVPEPEVLEYVAEDLPLEIVYQDEDVAVVNKPQGMVVHPSAGHTSGT
                     LVNALMYHIKDLSGINGVLRPGIVHRIDKDTSGLLMIAKNDDAHLALAQELKDKKSLRK
                     YWAIVHGNLPNDRGVIEAPIGRSEKDRKKQAVTAKGKPAVTRFHVLERFGDYSLVELQL
                     ETGRTHQIRVHMAYIGHPVAGDEVYGPRKTLKGHGQFLHAKTLGFTHPRTGKTLEFKAD
                     IPEIFKETLERLRK"
     CDS             19906..21801
                     /locus_tag="ctg1_894"
                     /transl_table=11
                     /translation="MKKKLTSLALVGAFLGLSWYGNVQAQESSGNKIHFINVQEGGSDA
                     IILESNGHFAMVDTGEDYDFPDGSDSRYPWREGIETSYKHVLTDRVFRRLKELGVQKLD
                     FILVTHTHSDHIGNVDELLSTYPVDRVYLKKYSDSRITNSERLWDNLYGYDKVLQTAAE
                     KGVSVIQNITQGDAHFQFGDMDIELYNYENETDSSGELKKIWDDNSNSLISVVKVNGKK
                     IYLGGDLDNVHGAEDKYGPLIGKVDLMKFNHHLDTKNSNTKNFIKNLSPEIIVQTSSSP
                     IGSYDSGQEINREYISWLESMGIQHINAASKDYDATVFDIRQDGLVNISTSYKPIPSFQ
                     AGWHKSSYGNWWYQAPDSTGEYAVGWNEIKGEWYYFNQTGILLQNQWKKWNNRWFYLTD
                     SGVAAKNWKKIAGIWYYFNKENQMEIGWIQDKEQWYYLDVDGSMKTGWLQYKGQWYYFA
                     PSGEMKTGWVKDKEAWYYMDSTGIMKTGEIEVAGHHYYLEESGAMKQGWHKKANDWYFY
                     KTDGSRAVGWIKDKDKWYFLKENGQLLVNGKTPEGYTVDSSGAWLVDVSIEKSATIKTT
                     SHSEIKESKEVVKKDLENKETSQHESVTNSSTSQDLTSSTSQSSETSVNKSESEQ"
     CDS             21902..23011
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AA_kinase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_895"
                     /sec_met_domain="AA_kinase (E-value: 5e-42, bitscore:
                     141.1, seeds: 128, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYKRIVFKVGTSSLTNEDGSLSRSKVKDITQQLAMLHEAGHELI
                     LVSSGAIAAGFGALGFKKRPTKIADKQASAAVGQGLLLEEYTTNLLLRQIVSAQILLTQ
                     DDFVDKRRYKNAHQALSVLLNRGAIPIINENDSVVIDEVKVGDNDTLSAQVAAMVQADL
                     LVLLTDVDGLYTGNPNSDPRAKRLERIETINREIIDMAGGAGSSNGTGGMLTKIKAATI
                     ATESGVPVYICSSLKSDSMIEAAEETEDGSYFVAQEKGLRTQKQWLAFYAQSQGSIWVD
                     KGAAEALSQHGKSLLLSGIVEAEGAFSYGDIVTVFDKESGKSLGKGRVQFGASALEDIL
                     RSQKAKGVLIYRDDWISITPEIQLLFTEF"
ORIGIN
        1 tgatgaaaag caggtttttc agatttatta tgatttttca gagacagttg gaactatgca
       61 aggctatcgt accttggctc tcaatcgtgg ggagaaactt ggtgtcttga agatcggttt
      121 tgaacatgcg acggaccgta ttcttgcctt ctttgctact cgtttcaagg tgaaaaatgt
      181 ttatattgat gaagttgttc agcaatccgt taagaaaaag gtcttgcctg ctatcgagcg
      241 tcgtattcgg acagaattaa ctgagaaagc tgaagaagga gctatccaac ttttttctga
      301 caatctgcgc aatctcctct tggttgctcc actgaaaggg cgcgtggttc ttggatttga
      361 cccagccttt cgtacaggtg ccaagttagc tgtcgtggat gcaacaggaa aaatgctgac
      421 aactcaggtt atttatcctg ttaaaccagc atcagctcgt caaatcgaag aagccaagaa
      481 agatttagca gatttaattg gtcaatacgg tgtagagatt attgccattg gaaatggaac
      541 ggccagtcgt gaaagtgaag cttttgtagc ggaagttctg aaagatttcc ctgaagtcag
      601 ctatgttatc gttaatgaaa gtggtgcttc tgtctattct gccagcgaac ttgctcgtca
      661 ggagtttcca gacttgaccg ttgaaaaacg ttctgccatt tctatcgccc gtcgtttgca
      721 agatcctctt gcggaattgg tcaaaatcga tcctaagtca attggtgtcg gtcaatacca
      781 acacgatgtc agtcagaaga aactatctga gagtctggac tttgttgtcg atacagtggt
      841 taaccaagtt ggtgtcaatg tcaatacagc tagcccagct cttctttcac acgtagctgg
      901 actcaacaaa actatctctg aaaatattgt caaataccgc gaggaagaag gaaaaatcac
      961 ttcacgcgcc caaatcaaga aagttcctcg tctgggagcc aaggcctttg agcaggctgc
     1021 tggtttcctt cgtatccctg aaagtagcaa tatccttgat aatacaggag ttcacccaga
     1081 gaattacact gcagttaagg aactcttcaa acgtttagat attaaagacc taaacgaaga
     1141 agcccaaagc aaactcaagt ccctttcagt caaggaaatg gctcaagagc tagacctcgg
     1201 tccagaaacc cttaaagata tcattgcaga tcttctcaaa ccaggtcgag atttccgtga
     1261 ttcctttgac gcacctgtgc ttcgccaaga tgtcctagat atcaaagacc tagtggtagg
     1321 tcagaagcta gaaggtgttg tgcgtaacgt tgttgacttc ggtgccttcg ttgatatcgg
     1381 gattcacgag gacggcttga ttcatatttc tcatatgagt cgcaagttta tcaaacaccc
     1441 tagtcaagtg gtgtcagttg gagatttggt gaccgtttgg gtcaagaaaa ttgatactga
     1501 acgtgaaaaa gttaatctgt cgctcctcgc tccaaatgaa actgactgat tatgtcaagc
     1561 aggtttcact agaagacttc gggagagctt ttatccatca tgtccagtgg aataggcgtc
     1621 tacgttcgac aggtgggcga tttttcccca aagatgggca tctggatttt aatcccaagg
     1681 tttatcagaa actgggtatg gaggttttta ggaaaattgt ccgacatgaa ctctgtcatt
     1741 atcaccttta tttccaaggg aagggctatc aacacaagga tcgggatttt aaggaacttt
     1801 tgaaagcagt ggatggatta cggtttgtac catccttgcc caatagtaac tctaaaccac
     1861 tcaagcttta tcgttgtcaa tcctgccagc aaaggtatca gcgcaagcgt aggattgata
     1921 ccaaacgcta tcgctgtgga ctttgtcgag gtaaattgct tctgataaat cagcctgagg
     1981 actgatgaaa gccgagcctc cccgtgatat actatgtcta acctagcaga aagaggaaat
     2041 atcatgaaca gtaaatttta taaaatgaga cgcaatcgca tgatttcagg agttctggca
     2101 ggtctgtcag acaagtggaa ttttgatgtt accctagttc gtttcttgtt tgctattttt
     2161 acagttgcaa actttggact tggcgtgatt atctatatca tcctagcttc tatcatgcct
     2221 accaaggaag aaatcgaagc agaaatgtac ggaacaggcc cacgtaaacg caaagaagcc
     2281 caagccattg acgacaatga aggctggttt tggtgaggtt ctacagaaga tttggaataa
     2341 gcaaaaagct ttaaatcaat agtctaaact gcttgattta aagctttttt acttttatac
     2401 tcaataaaaa tcaaagtgca aactaggaag ccagccacag gctgtaattt agtcggcaat
     2461 gtgaagttga catagtttgc actttgattt ttgaatagta ttaataatat ttcgccagct
     2521 tcatccacaa actatagtgg attggaacta gaatagtaca cctctacttc taaaacattg
     2581 ttagaaatcg atttgactat cctgatcgat ttgtcctgtt cttatttcat tttattataa
     2641 aagcagtaat ttaaacgcag ttttttaatc tatttttgct gctgagacaa tatatttttg
     2701 gaaaaatggt ggatgctgat aacaactgat aaccagcaaa taacataagc agtgccggta
     2761 aattctgtac cgataaagtg tgtgtgttca actaagagct gaccgatgaa tggagagagc
     2821 agatagagaa gtccgatgag tatatgttct ttgtgtttca ttaaagcgca ccttctttcc
     2881 ttataggttg aacgacttgc aagtgttaaa ttgaatggta tgttatctag gtaaccttac
     2941 taaaatgtta gttcccgctt cctccttttc aaagtaagcc ttttcacact tatattttac
     3001 aactttaaaa ataggaaatc aaatcatttt ctaagtaatt ttgcttatat ttcacccaat
     3061 cttacaaaaa tgtaagatta aagtctcttt tgtaaggtta ggttatggca agcggtcttt
     3121 ttttgatgta aactagactc ataaagaaca aaggagtaac atcatgaaac aaatcttaca
     3181 taagaaaact agaaaaccaa gtcacaaaga aattgagcgc gttcagctgg gatgcactat
     3241 gatgcaagct acatttcatt tgatgggata ttaagaaagg agattctcat gacactttta
     3301 gatgtaaaac acgttcaaaa aatttataaa acacgttttc agggcaacca agtagaagcc
     3361 ctcaaggata ttcactttac cgtcgaaaag ggtgactacg ttgccatcat gggtgagtct
     3421 ggttctggta aatcaactct tctcaatatt ctagctatgc tggataaacc aagtcgtggt
     3481 caggtttact tgaatggaac tgacaccgca accattaaaa attcacaggc ctctagcttc
     3541 cgtcgtgaaa agttgggctt tgtcttccaa gactttaact tgctagatac tctatctgta
     3601 aaggacaata tcttgcttcc gcttgtcttg tcaagaagac ctattacaga gatgatgaag
     3661 aaattggtgg tgacagctga gaatctggga ataaaccaat tacaagagaa gtacccttac
     3721 gagatttctg gtggtcagaa acagcgtgta gcagtagccc gcgccatcat cacagaacct
     3781 gaaattctcc ttgcggacga accgacagga gctcttgact ccaagtcatc tgcagcctta
     3841 cttgatgtct ttgatgaaat caatgagcgc ggccaaacca ttctcatggt aacccactca
     3901 acagcagcag ctagcagagc taaacgtgta ctctttatca aagacggcat tctttacaat
     3961 caaatctacc gtggagagaa gacagaacgt cagatgttcc aagaaatctc tgataccttg
     4021 actgtcatgg caagcgaggt gaattagtat gtttcgatta accaataagt tagcggtatc
     4081 gaacttgatt aaaaaccgca aactctacta tccttttgcg ctggctgttc tcttggcagt
     4141 cactgtcacc tatctctttt actctctaac cttcaatcct aagattgcgg aaatccgtgg
     4201 aggaacaacc attcaggcta cacttggatt tggtatgttt gtcgtcaccc ttgcgtcagc
     4261 cattatcgtt ttctatgcca atagttttgt catgaagaac cgttccaagg aactaggaat
     4321 ttatggcatg ttgggcttgg agaagcgtca tcttatcagt atgaccttta aggagttagt
     4381 ggtatttggg attctaactg ttggagcggg tatcggtatt ggagccttgt ttgacaagtt
     4441 aattttcgct ttcctgctca aactaatgaa attgaaggtt gagctggttg ctaccttcca
     4501 gacgaaagtt gtcattacag tgcttgttgt cttcggtttg attttcctag gcctcatgtt
     4561 cctgaatgcc cttcgaatcg cccgtatgaa tgccctccag ctctctcgtg agaaagctag
     4621 tggagagaaa aaaggtcgct tccttcctct ccaaaccatt cttggttcca taagtttagg
     4681 aattggctat tatcttgccc ttacggtaaa agatcctctt acagccttaa caaccttctt
     4741 catagctgtt ttactggtta tctttgggac ttatctcttg tttaatgcag ggattaccgt
     4801 tttcctccaa atcttaaaga aaaataagaa atactattac caaccaaata acctcatatc
     4861 tgtttctaac ttgattttcc gtatgaagaa aaatgcagtt ggactagcca ccatcgctat
     4921 cttgtcaaca atggttttgg taaccatgtc agcagcgaca agcattttca attcctcaga
     4981 aagctttaaa aaagttctaa atcctcatga ttttggggtt tcagggcaaa atgttgaaaa
     5041 agaagacttg gacaaactct tgagccagtt tgcaagtgac aaaggttata agattaaaga
     5101 aaaagaagta tttcgttaca cttactttgc tgttgcgaat caagaaggaa ccgagttaac
     5161 tatttttgaa aaaggacaaa accgtgtcca accaaaaaca attttcatgg tatttgacca
     5221 aaaagattat gaaaatatga ctggtcaaaa actgtctcta tcaggaaatg aggtcggact
     5281 ctttgcaaag aatgagggag ttaaagaaca gaaaactcta attctgaatg atcatcaatt
     5341 ttctgtaaaa gaagaattta ataaagattt tattgtcaag catgtcccaa atcagtttaa
     5401 tattttgact gctgattaca attaccttgt tgtacctgat ttacaagcct ttttgaacca
     5461 attcccagat tcggctatct ataatcagtt ttacggtggt atgaatgtaa atgtcagtga
     5521 agaagagcaa ctcaaagtcg ctgaagaata tgaaaaatac ttacaaaagt ttaatgctca
     5581 attaaacact gaaggtaact atgtgtatgg tagcactcta gcagatgcta gtgctcaaat
     5641 gagtgtcctc tttggcggtg tcttctttat cggtattttc ctatccatta tctttatggt
     5701 cggaaccgtt ctggtcatct actacaaaca aatttctgaa ggctacgaag accgtgagcg
     5761 ctttattatc ttgcagaaag tcggtttaga tcaaaagcaa atcaagcaaa ccatcaacaa
     5821 acaggtttta actgtattct tccttccttt gctctttgcc ttcctacatc tagcctttgc
     5881 ctaccatatg cttagtctga ttttaaaagt gattggtgta ctggatacga ctatgatgtt
     5941 gattgtgacc ttgtctatct gcgctatctt cctcatcgcc tatgtgctga ttttcatgat
     6001 tacttcaaga agttatcgca agattgtgca aatgtaaaaa agatacctcg acttcaaaat
     6061 cgaggtattt cttgttttct aaatgctgaa aagttgtccg agcaggaagg taactcccat
     6121 agttaagaga ccaatagcaa ggttccgaat catagctgtt ttggttgggg cttttccaag
     6181 tctagcgctt gtgtagccag tgagaagaag ggctacaccg acgataagga cggtagcagg
     6241 gatgcggtaa tcacttggaa aaatggtcac tgacagcatt ggaggcaaac ttctaaggaa
     6301 aaaggcaacg aagctagaaa tggcagcgtg ccaaggattg gtaaattctt catactcaat
     6361 cccatatttt tcctctacca gagccttgag tggattttta agaaagatct tattggtcaa
     6421 gagttgggca gaagttttgc attctccatt ttggatataa gcagcataga gggatttttt
     6481 ggctagttcc ctatcttggt ctaacaagag tttttctcgc gaaacggcag cttcctcggt
     6541 atcttttgga gttgaaacgg atacatattc tccaccagcc attgaaaagg caccagctaa
     6601 gatagccgca aatcctgata aaaagataat ccagatattg gtcgtggcac tggcaacccc
     6661 gataaccaca ccagcaatgg aaataattcc atcgttagca ccaagaacac ctgcgcgcag
     6721 gatatttaaa cgacctgcaa aatttgaatc gatttcgtga tttgtttctg acnnnnnnnn
     6781 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     6841 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnaaggagct tttccaagta gagaggcaat
     6901 ttctctattt gatttccctt cttttttcca tctttcgatt aagcgacggc tatcgattgt
     6961 caaatgtttg gcttttgtag tataattttc ttgcatctct gtgcctttct tgtgtttgtg
     7021 gttgaacaac aagtataaca cagaggtgtt ttcttatgcc tacaagagct atcagctagt
     7081 tgaaccatct aatttttagg agggctgggt ggctaacttc attatagaac tttcatttac
     7141 gaacatatag taaaatgaaa caagaacaga acaaatcgat caggacagta aaatctattt
     7201 ctaataatgt tttagaagca gaagtgtact attctagttt caatctatta tatttttgtt
     7261 ttttatcaaa aaatacttta caagttctta aaaacatgat atagtaataa agcttagaaa
     7321 atgagatgat gttttctagc aaatataaac ccgagtaaaa aatgcctacg gacaggcagg
     7381 gttgaatgcc gaagcgtggt tgaaaagcca cattattgat agggttaaaa gcctactttt
     7441 ataagttgat gttaggacac ttgtcctaat tcataaattt ttagtgtggt gaaagcacac
     7501 gtcatcttgt gaaacgatca ataaagtacg taatatttgc tactagagag ttaggaaaca
     7561 tcgggaacag acatactcaa cagaaaccaa aataaacacg tcagaagatt gcagagcagg
     7621 tgaaaacctg ctcttttttc atgagtcaac ctttagttcc ttagttttca taaggtccta
     7681 aaaatattga aaggagtatg ttttgaaaga gttagatcaa aaccaagccc caatttatga
     7741 ggccttggtg aagttacgca agaaaaggat tgttcccttt gatgttccag gtcacaagcg
     7801 tggacgggga aatccagaac ttgtcgaact cttaggagaa aaatgtgtag gcattgatgt
     7861 caattcgatg aaacccttgg ataatttagg ccatcctatt tcgattattc gtgatgcaga
     7921 ggagctggct gcagatgctt ttggagctag ccatgccttt ctaatgattg gtggaacaac
     7981 ttcatcggtg cagactatga ttctggcaac ctgcaaggca ggagataaga ttattctgcc
     8041 acgaaatgtc cataaatctg ctatcaatgc gttggttcta tgtggtgcca ttcccatcta
     8101 tatcgagatg agtgtagatc ctaagattgg tatcgcttta ggtcttgaaa atgaccgagt
     8161 agcacaggcc ataaaggacc atccagatgc taaggctatc ctaatcaaca atcctactta
     8221 ctacggcatc tgttcagacc taaaggggtt gacagaaatg gctcatgaag ctggcatgat
     8281 ggttttagta gatgaagccc atggagcgca tttgcatttc actggtaaac ttccaatttc
     8341 tgctatggat gcaggagctg atatggcagc agtttccatg cataagtctg gtgggagttt
     8401 gacacaaagt tcgcttcttt taatcgggga gcagatgaat cccgagtacg ttcgtcagat
     8461 tataaacctg acacagtcta catctgcctc ttacttattg atggctagtt tggatatttc
     8521 acgtcgcaac ttggcccttc gtggtaaaga gtcgtttgag gaagtcattg agctatccga
     8581 gtacgctcgt catgaaatca atgccattgg cggttactat gcttactcaa aagagttaat
     8641 agatggtgtg tcggtctgtg attttgatgt aaccaagttg tcagtttaca ctcagggaat
     8701 aggcttaaca ggtatcgagg tttatgacct cttgcgagac gaatacgaca ttcagatcga
     8761 gtttggtgat atcggcaata tcttggccta tatttccatc ggcgaccgca tccaagacat
     8821 cgagcgcttg gttggtgctc tggctgatat taagagactc tattcacgag atgggaagga
     8881 cttaatagct ggagaatata ttcagcccga gttggtgctg tctccacaag aagccttcta
     8941 ttcagagaga aaaagtttga ccttagatga gtctgttgga caggtctgtg gagaatttgt
     9001 catgtgctat cctccaggga ttcctatctt ggctcctggt gaacgcatta cacgagaaat
     9061 tgtagactat atccaattcg ccaaggaacg tggttgctcc ctccaaggga cggaagatcc
     9121 agaggtcaat catatcaacg ttattaagag aaagacaaac tataagaaaa gtcaatagtt
     9181 ttatctaaac tatttcttat ttcaatttga tgatttggcg atgattttag agcacggcaa
     9241 aaagcccttg aattagaagc ggtcaatcgc ttaatttcta tcagcttatc aaatcctgcc
     9301 tcaatccttt tctgaggatt agggtagcgt gtcaagagtt ggtaggtata ttctgaatgc
     9361 tttccaacga ttttatccaa ctcaggaaag atgatatcaa gacaacgagt gtattgtnnn
     9421 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     9481 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     9541 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     9601 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     9661 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     9721 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     9781 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     9841 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnng cctttcggaa atcgttaagc
     9901 gattggagga aatgaactaa tccacagtga cttattccaa gtataccact tgggctttgg
     9961 cagtagctaa ctgcgctaaa tataatataa ggagaaatag atggatttat ggttttctga
    10021 agttcatact ccagatgtca aattgtctct gagaacagcc aagcaacttt acgctggaaa
    10081 aagtgaatgg caggatatcg aagtcttgga tacgccagct tttgggaaaa tactgatttt
    10141 aaatggccat gtcttgttct cagatgcgga tgatttcgtc tacaatgaaa tgaccgtcca
    10201 cgttcccatg gctgtccacc caaatccaaa gaaagtattg gttattgggg gtggtgacgg
    10261 cggtgttgcc caagtattaa cactctatcc tgaactggaa caaatcgata tcgtggaacc
    10321 ggatgagatg ttggtcgagg tctgtcgtga gtatttccca gactttgctg cagggctaga
    10381 tgatcctcgt gttaccattt actaccaaaa tgggctacgc tttttgcgaa actgcgaaga
    10441 tgattacgat attatcatca acgatgcgac agatccattt ggccatacgg aaggactctt
    10501 taccaaggaa ttctacggca atagttatcg agctctgaag gaagacggca tcatgattta
    10561 ccagcatggg agtcccttct ttgacgagga tgagtcggcc tgccgaagca tgcaccgcaa
    10621 ggtcaatcaa tcctttccaa tcagtcgggt ttatcaggcc catattccaa ctagcccagc
    10681 tggctattgg ttgtttggat ttgcatcgaa aaaataccac cctgtcaaag attttgacaa
    10741 ggaaggttgg aaaaaacgcc agcttttcac agaatactac actgcaaact tacacgtggg
    10801 atcctttatg ttgcccaagt atgttgagga cattttagaa gaagaggaag gaaaaaaatg
    10861 agtcgtttac tagttattgg ttgtgggggc gttgcccaag ttgctatttc aaagatttgt
    10921 caagatagcg aaacatttac agagattatg attgctagcc gtaccaagtc aaaatgcgat
    10981 gacttgaaag cgaagctaga aggcaaaaca agtactaaaa ttgaaactgc agcacttgat
    11041 gctgacaagg ttgaagaagt gattgccctg attgaaagct acaaaccaga agctgttttg
    11101 aatgtagctc tgccttatca agatttaacc attatggatg cttgtttggc aacaggtgtt
    11161 cactatatcg atacagccaa ctacgaagca gaagacacag aagaccctga gtggcgtgct
    11221 atctacgaaa aacgttgtaa ggaacttggt tttacagcct actttgacta ctcatggcag
    11281 tgggcttatc aagagaaatt caaagaagca ggcttgactg ctcttcttgg ttctggcttt
    11341 gacccaggtg taactagtgt cttttcagct tatgccctca aacactattt tgatgaaatc
    11401 cattatatcg acattttaga ctgtaatggc ggtgaccacg gttatccatt tgcaaccaac
    11461 tttaatccag aaattaatct ccgtgaggtt tctgcgccag gttcttactg ggaagatggg
    11521 aaatgggtcg aagtcgaagc tatgtctatc aagcgtgagt atgatttccc tcaagttgga
    11581 caaaaagata tgtatctcct tcaccatgaa gaaatcgaat cattggccaa gaacattcca
    11641 ggtgtcaaac gcattcgttt ctttatgact tttggtcaat cttacttgac gcacatgaaa
    11701 tgtcttgaaa atgttggact ccttcgtacg gataccatta actttaacgg ccaagaaatt
    11761 gttccaattc aatttttgaa agccttgctt ccagatcctg ctagccttgg cccacgtact
    11821 gtaggtaaaa ccaatattgg atgtatcttt acaggtgtca aagatggcgt tgaaaagact
    11881 atctacatct acaatgtttg cgaccatcaa gagtgctatg cagaagtcgg gtcacaagca
    11941 atttcataca cgacaggcgt tccagccatg attgggacaa aattagtcat gaacggaact
    12001 tggaaacaag ctggagtgta taaccttgag gagttagatc cagatccatt catggaagct
    12061 ttgaatgagt atggtttgcc atgggttgtg gttgaaaatc tacaaatggt ggactaatga
    12121 agttagaaca agtaccaaca ccagcctatg ttattgactt ggccaagtta gaagctaatt
    12181 gccgcattct acaatatgta caagaagagg tcggttgcaa ggtcttgctt gcccagaagg
    12241 catattccct ctacaaaact tatcccttga ttagccagta tctatcaggt acgacagcta
    12301 gtggactcta tgaggccaaa ttggcaaggg aagaatttcc tggtgaagtc catgtatttg
    12361 cgcctgcttt caaggatgca gacttggagg aattgcttgg gataacagac catatcgtct
    12421 ttaactcaga gagacagttg cgtaagcatg gggctcgttg tcgagaggct ggtgtcagtg
    12481 ttggtttgcg cctcaaccct cagtgttcaa ctcaaggaga tcacgcgctc tatgaccctt
    12541 gtgcaccagg ttctcgcttt ggagttacta tagacaagat tccgagtgat ttgctagatt
    12601 tggttgacgg acttcatttt catacccttt gcgagcaggg agcagatgat ttacaaacaa
    12661 ctttgaaagc agtagaagaa cagtttggtc cctacttaca tgaggtaaaa tggctcaata
    12721 tgggtggtgg tcatcatatt acaagagaag gttacgatgt ggatttgctg atttcagaaa
    12781 tcaagcgtat ccgaaaaact tacaatcttg aaatctatat cgagcctggt gaagccattg
    12841 cgcttaatgc gggttattta gcaactgagg tattagatat tgtagaaaac ggtatggaaa
    12901 tcttggtttt agacgcctct gcgacctgcc atatgcctga tgtacttgag atgccctatc
    12961 gtccaccttt gagaaatggc tttgaggcac aggaaaaagc ccatacctac agactttctt
    13021 ctaatacctg tctgacgggc gatgtgattg gtgattatag ttttgaaaat ccagtccaaa
    13081 tcggagacag actttatttt caagacatgg ccatttattc ttttgtcaaa aataatacct
    13141 ttaatggtat tggattgcca agtctctatc tcatggacga acagggagac tgtagcttac
    13201 tcaaagcttt tggctatcaa gactttaaag ggagattatc atgatggaca gtccaaaaaa
    13261 attaggctat cacatgccag cagagtacga accccatcat ggtaccctca tgatatggcc
    13321 gactcgacca ggatcatggc cttttcaagg aaaggatgct aaaagagcat ttactcagat
    13381 catcgagact atagcagaag gggaaagagt ctatcttttg gtggagcagg cctatctatc
    13441 tgaagcccaa tcctatcttg gggacaaggt tgtttattta gacattccca ccaatgatgc
    13501 ctgggcgcgt gatactggcc caaccattct cgtcaatgat aaaggtaaga aattagccgt
    13561 ggattgggcc ttcaatgctt ggggaggcac ctatgatggt ctttatcaag attatgaaga
    13621 ggatgaccaa gtagccagtc gttttgctga ggccttggaa aggcctgtct atgatgctaa
    13681 accttttgta ctggaaggag gtgcaatcca tagcgatggt caaggaacta ttctcgtaac
    13741 tgaaagttgc ttgcttagtc ctggtcgcaa tcctaacttg actaaagagg agattgaaaa
    13801 cacattatta gaaagtcttg gtgctgaaaa agttatttgg cttccttatg gtatttatca
    13861 ggatgaaacc aatgaacacg tcgataatgt tgctgccttt gttggtcctg ctgaggttgt
    13921 tttggcttgg acagatgacg aaaatgatcc ccagtatgcc atgtcaaaag cagatctcga
    13981 actcttagaa caggaaacag atgcaaaagg ttgtcacttc accattcata aattgcctat
    14041 ccctgcagtt cgacaagttg tgacagaaga agatttgcca ggctacatct atgaagaagg
    14101 agaagaagag cgatacgcag gtgaacgact agcagcttcc tacgtaaact tttatatcgc
    14161 caacaaggct gtcttggttc cacagtttga ggatgtaaac gaccaagtgg ccttagatat
    14221 cctcagcaag tgtttcccag accgtaaagt tgtcggaata ccagccagag atattctctt
    14281 aggtggtggc aatatccact gtatcaccca acaaattcca gaataggaga aaaagatgag
    14341 aaatgtaaga gttgcaacca ttcagatgca atgcgctaag gatgtggcaa caaatatcca
    14401 aaccgcagag cgtttagtac gtcaggctgc tgagcaagga gcccaaatta ttctcttgcc
    14461 cgagttgttt gaacatccct atttctgtca ggaacgtcag tatgactact accagtatgc
    14521 ccaatctgta gcggaaaata ctgccattca gcattttaag gtgattgcta aggaactaca
    14581 agttgtttta ccaatcagtt tctatgaaaa agatggtaat gtcttgtata actctattgc
    14641 cgtcattgat gcagatgggg aagtgctggg cgtttatcga aagacccata taccagatga
    14701 ccattattat caagaaaaat tctatttcac gcctggtaac actggtttca aggtctggaa
    14761 tactcgctat gctaagattg gtatcggtat ctgttgggat caatggttcc ctgaaacagc
    14821 gcgctgtctt gcattgaatg gtgctgaatt gctcttttat cctacagcta tcggttcaga
    14881 gccaattttg gatacagata gttgtggtca ctggcaacgt actatgcaag ggcacgcagc
    14941 agcgaatatt gttccagtca tcgcagccaa tcgttatggt ttagaggagg ttactcctag
    15001 tgaggaaaat ggcggacaga gttccagtct tgacttctac ggttcctcct ttatgacgga
    15061 tgaaacagga gctattctag aacgagctga aagacaagaa gaagctgttc tgttagctac
    15121 ttatgaccta gacaagggag caagtgaacg tctaaactgg ggcttgtttc gagatagaag
    15181 accagaaatg tatagacaaa ttacagatta gtgtgggaga aatgagagat tcattctgct
    15241 agactaactt cttattagca actataagat actatggcat ctagtaaatc gatttttatg
    15301 attcgctatt cttgtctatt gattagtccg tattttaaat attagcaaaa aagcaaatag
    15361 cagtaacttc tgtctatttg cttttctttt ttatagaata tatttctcaa tagcacgcgc
    15421 aacgccgtct tcttcgttgc ttgaggtaac ggcatccgca agagatttga cataatcgct
    15481 ggcatttccc attgcaatcc caagccctgc aaactggagc atttcgatat cgttattagc
    15541 atcgcccatg gccataatct ctgaggaatc aatcttcaaa atctcagcaa gtcgtgaaag
    15601 agcagtagcc tttgtcgttc caagtggcat tgcttcataa atgacaggct gcgaacgaac
    15661 tccactgaat cgttggcaaa gctcttcagc aaaacgctgc tcaaaatcgt ctgtttgttc
    15721 ttttgttcct aaaaacatac cttggaacat ccggaacttt ccactagtcg cttcttcaag
    15781 agaaatttca gtcaggtctg aaaatactag tttagcatca ttttcaataa cttgattggg
    15841 cttgccaccg agaacaaaat aatgtgactc gtcaaaaagt gtcaactgaa catcactctt
    15901 ttcagcaagg tcatagaggt attcgatgtc agctggactc agttcttgcc agtcaaccaa
    15961 gccccagtcg ctagtctggt gagttgaaca accgttgtta acaatcacat attcgttctg
    16021 gaggtcaagc cccagttttt tgtagtaggg gaggacaccg aaaagggggc gacccgtaca
    16081 gaggaccagt ttgacacctt tttcaatggc ttggtgaata gcagcgatgt gagcctgtgg
    16141 gatttccttg gcttcattga ggagggttcc atccatatcc aaggctagta gtttaatcat
    16201 aggtcttcct tctttatctt ttggtattat tatagcatat tttggagaag aaattgatag
    16261 aaagcttgag actaattgat tttatagttt aagatgtttt gatgacaatt catgatttga
    16321 agaggatatt tggcaaagat atgctatact atgtttgtca atgttgcaac tagacaaatt
    16381 aaaaaaccaa cttaatataa tagttttttt gtaagtaggt atgagtatca gattactcaa
    16441 ctaatctaaa caataacgga ggaaatatat catgatttta atgacaaaaa atataaatct
    16501 aacaaatgaa gaattagagc tgatacaagg tggagcagat ccctatggta aagaacctaa
    16561 tggttattat ccttggcaaa tggaaccagt attaactatg ccggttcatg gattttgtcc
    16621 cagaggaacc gatgatttag tatatattgt aggaggtaat catctttgca aaggaagtgc
    16681 tgcgagattt taagtaaaat ttattaggaa tatgaagaaa caaggggaga aaacagagga
    16741 tttaatatga aaaaacgagc tattcaaatt ttactagcat tgtccttaat tttttacaaa
    16801 tcaacttggt tttggaggct tttcaattat ctcgcaaagc cctatctacc agcaagtcgt
    16861 gaattttttc agattctact tttgctggaa agtggtgttc ttttgtcagc agtcatctat
    16921 ctactagttt ttgcaggaaa gaagattttt catttcaagt ggcagttgag gtactttatc
    16981 taccttttac tgggctacat catttcgtat atgtctgact ttctcttttc gtatttcata
    17041 tccccgcctt caaatcaaat ttctttgaat gaaacgatag aaatgatggg acgacaggag
    17101 ttcccttatt tcttgctcat cgtttgcttc atcgccccta ttgctgagga attgatttat
    17161 cgcggtgtga ttatgacaac ctttttcaaa aactcgcctt ggtacggaga tgttttgctt
    17221 tctgctatta ttttcggtta tattcatatc aattttgctt taactcctct tgcttttttc
    17281 atttatgcta gtggaggtct tattttagct ctattgtatc gcatgactaa aaatctctac
    17341 tatccaatac tagttcatat tctcatcaat atcactgcct tctgggatgt gtggttactc
    17401 ctattttcag gaagttagct tactaaaaaa atgtcggaat tttccggcat tttctttttt
    17461 cacaaatagt caacgttttt ctttccgata ctgaagtggt gtgtagccac ttattttttt
    17521 gaattgattt tgaaaataag attggcgtga gaaaggcaga tagtgaagat agttaagaag
    17581 aataggatgt tcttttttcc tttttggaaa acttctaaaa tatggtataa tgaaaagata
    17641 aagaagttgg gggtagaaga tgaacattca acaattacgc tatgttgtgg ctattgccaa
    17701 tagtggtact tttcgtgaag ctgctgaaaa gatgtatgtt agtcagccga gtctgtctat
    17761 ttctgttcgt gatttggaaa aagagttggg ctttaagatt tttcgtcgga ccagctcagg
    17821 gactttcttg acccgtcgtg ggatggaatt ttatgaaaaa gcgcaagaat tggttaaagg
    17881 atttgatatt tttcaaaatc agtatgccaa tcctgaagaa gaaaaagatg aattttccgt
    17941 tgctagccag cactatgact tcttaccacc aactattacg gccttttcag agcgctatcc
    18001 tgactataag aacttccgta tttttgaatc aactactgtt caaatattag atgaagtggc
    18061 gcaagggcat agtgagattg ggattatcta cctcaacaat caaaataaaa aggggattat
    18121 gcaacgggtt gaaaagttag gtctggaggt catcgaattg attcctttcc atacccatat
    18181 ttatctctgt gagggtcatc ctttagccca gaaagaggaa ttagtcatgg aggatttagc
    18241 ggatttacca acggttcgtt tcactcaaga gaaagacgag tacctttatt attcagagaa
    18301 ctttgttgat accagcgcta gctcacagat gtttaatgtg acagaccgtg ccaccttgaa
    18361 tggtattttg gagcggacgg acgcctatgc gacaggttct ggatttttag atagtgacag
    18421 tgttaatggc attacagtta ttcgtctcaa ggataaccta gataaccgca tggtctatgt
    18481 taaacgtgaa gaagtggagc ttagtcaagc tgggactctc ttcgtagaag tcatgcaaga
    18541 atattttgat caaaagagga aatcatgaaa aaaagagcaa tagtggcagt cattgtactg
    18601 cttttaattg ggctggatca gttggtcaaa tcctatatcg tccagcagat tccactgggt
    18661 gaagtgcgct cctggattcc caatttcgtt agcttgacct acctgcaaaa tcgaggtgca
    18721 gccttttcta tcttacaaga tcagcagctg ttattcgctg tcattactct ggttgtcgtg
    18781 ataggtgcca tttggtattt acataaacac atggaggact cattctggat ggtcttgggt
    18841 ttgactctaa taatcgcggg tggtcttgga aactttattg acagggtcag tcagggcttt
    18901 gttgtggata tgttccacct tgactttatc aactttgcaa ttttcaatgt ggcagatagc
    18961 tatctgacgg ttggagtgat tattttattg attgcaatgc taaaagagga aataaatgga
    19021 aattaaaatt gaaactggtg gtctgcgttt ggataaggct ttgtcagatt tgtcagaatt
    19081 atcacgtagt ctcgcgaatg aacaaattaa atcaggccag gtcttggtca atggtcaagt
    19141 caagaaagct aaatacacag tccaagaggg tgatgtcgtc acttaccatg tgccagaacc
    19201 agaggtatta gagtatgtgg ctgaggatct tccgctagaa atagtctacc aagatgagga
    19261 tgtggctgtc gttaacaaac ctcagggaat ggttgtgcac ccgagtgctg gtcataccag
    19321 tggaacccta gtaaatgccc tcatgtatca tattaaggac ttgtcgggta tcaatggggt
    19381 tctgcgtcca gggattgttc accgtattga taaggatacg tcaggtcttc tcatgattgc
    19441 taaaaacgat gatgcgcatc tagcacttgc ccaagaactc aaggataaaa agtctctccg
    19501 caaatattgg gcgattgttc atggaaatct gcctaatgat cgtggtgtaa ttgaagcgcc
    19561 gattggccgg agtgaaaaag accgtaagaa acaggctgta actgctaaag ggaagcctgc
    19621 agtgacgcgt tttcacgtct tggaacgctt tggcgattat agcttagtag agttgcaact
    19681 ggagacaggg cgcactcatc aaatccgtgt ccacatggct tatatcggcc atccagtcgc
    19741 tggtgatgag gtctatggtc ctcgcaagac tttgaaagga catggacaat ttcttcatgc
    19801 caagacttta ggttttactc atccgagaac aggtaagacc ttggaattta aagcagatat
    19861 cccagagatt tttaaggaaa ccttggagag attgagaaag taagaatgaa aaagaaatta
    19921 actagtttag cacttgtagg cgctttttta ggtttgtcat ggtatgggaa tgttcaggct
    19981 caagaaagtt caggaaataa aatccacttt atcaatgttc aagaaggtgg cagtgatgcg
    20041 attattcttg aaagcaatgg acattttgcc atggtggata caggagaaga ttatgatttc
    20101 ccagatggaa gtgattctcg ctatccatgg agagaaggaa ttgaaacgtc ttataagcat
    20161 gttctaacag accgtgtctt tcgtcgtttg aaggaattgg gtgtccaaaa acttgatttt
    20221 attttggtga cccataccca cagtgatcat attggaaatg ttgatgaatt actgtctacc
    20281 tatccagttg accgagtcta tcttaaaaaa tatagtgata gtcgtattac taattctgaa
    20341 cgtctatggg ataatctgta tggctatgat aaggttttac agactgctgc agaaaaaggt
    20401 gtttcagtta ttcaaaatat cacacaaggg gatgctcatt ttcagtttgg ggacatggat
    20461 attgagctct ataactatga aaatgaaacc gattcatcgg gtgaattaaa gaaaatttgg
    20521 gatgataatt ccaattcctt gattagtgtg gtaaaagtca atggcaagaa aatttacctt
    20581 gggggcgact tagataatgt tcatggagca gaagacaagt atggtcctct cattggaaaa
    20641 gttgatttga tgaagtttaa tcatcattta gatacaaaaa attctaatac aaaaaatttt
    20701 ataaaaaatt tgtctcctga gataattgtt caaacttcct cctcaccaat tggttcgtat
    20761 gatagcggtc aagaaataaa tagggaatat attagttggc ttgaatcaat gggaattcaa
    20821 catataaatg cagccagcaa agactatgat gcaacagttt ttgatattcg acaagacggt
    20881 ttagtaaaca tttcaacttc ctacaagcct attccaagtt ttcaagctgg ttggcataag
    20941 agttcatatg gaaactggtg gtatcaagcg cctgattcta caggagaata tgctgtcggt
    21001 tggaatgaaa ttaagggtga atggtattac tttaaccaaa cgggtatctt attacagaat
    21061 caatggaaaa aatggaacaa tcgttggttc tatttgacag actctggtgt tgctgctaaa
    21121 aattggaaga aaatcgctgg aatctggtat tattttaaca aagaaaacca gatggaaatt
    21181 ggttggattc aagataaaga gcagtggtat tatttggatg ttgatggctc tatgaagaca
    21241 ggttggcttc aatataaggg gcaatggtat tactttgctc catcagggga aatgaaaacg
    21301 ggctgggtaa aagataaaga agcctggtac tatatggatt ctactggtat catgaagaca
    21361 ggtgagatag aagttgctgg acatcattac tatctagaag aatcaggagc tatgaagcaa
    21421 ggctggcata aaaaggcaaa tgattggtat ttctacaaga cagacggttc acgagctgtg
    21481 ggttggatca aggacaagga taaatggtac ttcttgaaag aaaatggtca attacttgtg
    21541 aacggtaaga caccagaagg ctatactgtg gattcaagtg gtgcctggtt agtggatgtt
    21601 tcgatcgaga aatctgctac aattaaaact acaagtcatt cagaaataaa agaatccaaa
    21661 gaagtagtga aaaaggatct tgaaaataaa gaaacgagtc aacatgaaag tgttacaaat
    21721 tcttcaacta gtcaagattt gacatcctca acttcacaaa gctctgaaac gagtgtaaac
    21781 aaatcggaat cagaacagta gtagaaaaga aggttttagg gccttctttt tcctatcaac
    21841 tcttttctat ttcctgttat tcatgttata atggataaat atgaataatc ggagtgagac
    21901 tatgaaatac aaacggattg tctttaaggt gggtacttct tctctgacaa atgaggatgg
    21961 aagtttatca cgtagtaagg taaaggatat tacccagcag ttggctatgc tgcacgaggc
    22021 tggtcatgag ttgattttgg tgtcttcagg tgccattgcg gctggttttg gagccttagg
    22081 atttaaaaag cgtccgacta agattgctga taaacaggct tcagcagcgg tagggcaagg
    22141 gcttttgttg gaagaatata caaccaatct tctcttgcgt caaatcgttt ctgcacaaat
    22201 cttgctgacc caagatgatt ttgtggataa gcgtcgttat aaaaatgccc atcaggcttt
    22261 gtcggtttta ctcaaccgtg gggcaattcc tatcatcaat gagaatgata gtgtcgttat
    22321 tgatgaggtc aaggttgggg acaatgacac tctaagtgcc caagtagcgg cgatggtcca
    22381 agcagacctt ttggttctct tgacagatgt ggacggtctc tatactggaa atcctaattc
    22441 agatccaaga gccaaacgct tggagagaat agagaccatc aatcgtgaga ttattgatat
    22501 ggctggtgga gctggttcgt caaacggaac tgggggtatg ttaaccaaaa tcaaggctgc
    22561 aactatcgcg acggaatcag gagttcctgt ttatatctgc tcatccttga aatcagattc
    22621 catgattgag gcggcagagg agaccgagga tggttcttac tttgttgctc aagagaaggg
    22681 gcttcgtacc cagaaacaat ggcttgcctt ctatgctcag agtcaaggtt ctatttgggt
    22741 tgataaaggg gctgcggaag ctctctctca acatggaaag agtcttctct tatctggtat
    22801 tgttgaagca gaaggagcct tttcttacgg tgatatcgtg acagtatttg acaaggaaag
    22861 tggaaaatca cttggaaaag gacgcgtgca atttggagca tctgctttgg aggatatatt
    22921 gcgttctcaa aaagccaagg gtgtcttgat ttaccgtgac gactggattt ccattactcc
    22981 tgaaatccaa ctacttttta cagaatttta gaggtaaact atggtgagta gacaagaaca
    23041 atttgaacag gtacaggctg ttaaaaaatc gattaacaca gctagtgaag aagtgaaaaa
    23101 tcaagccttg ctagccatgg ctgatcactt agtggctgct actgaggaaa ttttagcggc
    23161 taatgccctc gatatggcag cggctaaggg gaaaatctca gatgtgatgt tggatcgtct
    23221 ttatttggat gcagatcgta taga
//
