LOCUS       NZ_HE578907.1          17373 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_HE578907.1 Anaerococcus senegalensis JC48 strain type strain:
            JC17, whole genome shotgun sequence.
ACCESSION   NZ_HE578907
VERSION     NZ_HE578907.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-03-14 00:32:08
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 17373
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..17373
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[4117:7373]"
                     /cutoff="10000"
                     /detection_rule="(Amidinotransf and OTCace and OTCace_N and
                     AA_kinase)"
                     /neighbourhood="10000"
                     /product="Arginine2_Hcarbonate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      4118..7373
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Amidinotransf and OTCace and OTCace_N and
                     AA_kinase)"
                     /neighbourhood="10000"
                     /product="Arginine2_Hcarbonate"
                     /protocluster_number="1"
     cand_cluster    1..17373
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Amidinotransf and OTCace and OTCace_N
                     and AA_kinase)"
                     /kind="single"
                     /product="Arginine2_Hcarbonate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..17373
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Arginine2_Hcarbonate"
                     /region_number="1"
                     /rules="(Amidinotransf and OTCace and OTCace_N and
                     AA_kinase)"
                     /tool="gutsmash"
     CDS             complement(1849..2553)
                     /locus_tag="ctg1_1"
                     /transl_table=11
                     /translation="MEFIASESFWELFPEAEIGLILFKDIKMEEKSNREIRDKLDDANE
                     KALDYLTKPVFSENPVIKVWRDAFRKFKTKKGARCSIEALLKRVSKDKDVGSINPLVDI
                     YNATSLNYALPCGAEDIDKFVGDLKLEITEGDDPFQAIGDDKNSPTLEGELCYRDDKGA
                     VCRCFNWRDGQRTMITDQTKNAILFMENLDTERKEDLRNAINYLAENLENHLEGNVEIH
                     FITKDNPSVEIK"
     CDS             complement(2577..3839)
                     /locus_tag="ctg1_2"
                     /transl_table=11
                     /translation="MVISNIQTKISTISDLSKICSFEVEFQDKSTTTLIHSTARLLLIK
                     RGKGKFMINGVEYLIEKNTMISILPWDITTITDVTEDLEFYKIVYNFQIINDDLRNICN
                     FRKNQINSIEFLSKNPIKILDNESYYNMESSFIEIKDEVGNDSYQEEITKKEYSDEFLI
                     SSIIRILIKFLRFENKCKIKTDISFDQQVKINQILRYIYSHMSEKLTLDRLSSTFFISK
                     STLTKYIDENTGFTFTELLNRIRFSKAIDLLMFSDKSLTEIAKSVGYTDSSHFTKIFES
                     TEGIKPGEFKKYYNIKQMSLKQSEQKLLVDVVNYEINNFNDANLTIGKVAKTFGISTSE
                     VNRLIYFQFEKNFYEYLDELRISKACELLKTTDLKIIDVAMKVGYNSTRTFQRSFGRLT
                     GISPNKFRSSINYQDSEGNII"
     CDS             4118..5344
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Arginine2_Hcarbonate: Amidinotransf"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_3"
                     /sec_met_domain="Amidinotransf (E-value: 1.9e-96, bitscore:
                     319.4, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSIQVTSEIKPLKKVLVHRPGEELLNLTPSTLEELLFDDIPDLK
                     SAQEEHDRFTDIMRDNGVEVVYLEDLMAETLDANDGLRETFLEEYLSETGCEDKDILAK
                     AKEYLEKIEDTKEFVEKTMAGLTLKELGLFTEEDLHEMVVGQSYLAINPMPNLYFTRDP
                     FSSVGNGAVINKMYSVTRNRETIYCDYIFRFHPEYKEVPDLYGRKNEFHIEGGDTFNGN
                     ENTLLIGISQRTQYDAIKVLAKNLFFGDVENKIEKIYALKIDENRAFMHLDTVFTQIDY
                     DAFTYHPAIIKEMEVKIITKDEENNDLHIETASGKLDEILAEALGIEKVRLIPCGGGDP
                     IAAEREQWNDGSNTLTLAPGKVLVYKRNTVTNEVLRKEGIEVLELEASNLTVGRGGPRC
                     MSMPLEREL"
     CDS             5403..6407
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Arginine2_Hcarbonate: OTCace"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Arginine2_Hcarbonate: OTCace_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_4"
                     /sec_met_domain="OTCace (E-value: 2.8e-55, bitscore: 183.0,
                     seeds: 50, tool: rule-based-clusters)"
                     /sec_met_domain="OTCace_N (E-value: 4.6e-45, bitscore:
                     149.6, seeds: 1463, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPVNLQGQSILGLKFLSEDQIKYLIDLGEQFKKLKMTRTPHKYLE
                     GKNIVLLFEKTSTRTRCSFEVAGMDLGMGVTYLDPGSSQMGHKESIEDTAKVLGRFYDG
                     IEYRGFDQELVEKLAEHSGVPVWNGLTDEFHPTQMIADMLTIKENFGYLKGLNFVFMGD
                     CRNNVSNSLMVACAKLGINYTGCGPKELWADDKLVEEAKEFAKVHGSKVEFTEDVEEAA
                     KGAHAVYTDIWVSMGEPKEVWEKRIEILHPYQVNQKVMDLADDDAIFLHCLPSFHDLET
                     TTGKDVKEKFGDKYDLDGMEVKDDVFLGKQSKVFDQAENRMHTIKAIMYATLK"
     CDS             6438..7373
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Arginine2_Hcarbonate: AA_kinase"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_5"
                     /sec_met_domain="AA_kinase (E-value: 2.4e-34, bitscore:
                     115.3, seeds: 128, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKKRLVIALGGNALGNTPAEQLELVKKTAKTIVDLSENYDIAVG
                     HGNGPQVGMINNAMEFSANKGGDTPEMPFPECGAMSQGYIGYHLSQSIRNELKNRNKDS
                     EIACVVTQVMVDENDEAFNKPTKPIGSFLTKEEAEAKQKENGYEYVEDAGRGYRRVVAS
                     PIPKEIIEINIVENLVNNGNIVITVGGGGVPVIETEEGLEGVPAVIDKDRSSALLAQEL
                     NADMLVILTAVDRVMINYNKPNQEEIEEMTVEEAKKYIEEGHFAPGSMLPKVEACLEFV
                     EKSDKGRALITSLEKAAEALEGKTGTIIKK"
     CDS             7383..8888
                     /locus_tag="ctg1_6"
                     /transl_table=11
                     /translation="MKKEKKKSLSAFSILMIVLAAVCLITFITSGKPIDSDIIKSLDPT
                     KYEDLINTVKAGETVTVESAKLSDFVMAIPNGFMDAADLIVFILCIGGFIGIVMSTGAM
                     EAGIRSLVRKNKGKEGRLIAVLMFLFSVGGSTYGMAEETIGFYPLITAAMVAAGLDTMV
                     AVGTVLLGAGAGVLGSTINPFATSAAMGALESVGIKSNATIVMVIGVILWLSTDIIVIK
                     FVLNYAKKLLSNKEASVLTADEKHDMQEYFAKDTEGDLEFTGTHKAVLTIFAITFVIMI
                     ASLISYVDINFKGDEEAYLKVFGWSDFLTGSPLGYWYFKDLAALFTLSSIVIAIVAKIS
                     EKEFVDGFIAGAADLLSVGLIIAVARGITVVMSSTHLDFYILQNSAKLLKGVSPFVFAP
                     LAYLIYMVLSFLVPSTSGLAALSIPIMGSLANQLGYDPNIMIMIFCAACGLVNFVTPTS
                     GVVMGGLAAAKVEYSTYLKWVRKPFIIVFIANIIILSIAMSVM"
     CDS             9459..10685
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Trypsin_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1057:Trypsin-like peptidase (Score: 112.2; E-value:
                     1.3e-34)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_7"
                     /sec_met_domain="Trypsin_2 (E-value: 2.8e-33, bitscore:
                     112.2, seeds: 183, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRRNKGSGGFSNFLSGLIGAVLGGFLVFSLLGSSINNGNSKNSS
                     NNNSKEKNKSVINIDTSDDITMERAVVKKSIDSVVGITTKTKATQNTIFGPQTGYVEGV
                     GSGSIVTKDGYILTNSHVVSNGDASEINVLFSNNKSLKAELVWNDTTLDLAVIKVNANN
                     LNPIDLGDSDEINVGDRAVAIGNPLGLELQSTVTSGIISGLNRTVSFENGAQMDGLMQT
                     DAAINAGNSGGALLNSKGELIGINTAKAGNSDGIGFAIPVNLAKKVVDQISKNGKFNSV
                     YLGITGINLDLLLQSNNIDPKNVGSEDGVYVQSVVDDAKNYFRKGDIIVGIDGQKVKDM
                     SSLKKLLLNYSVGDKAKVEIVRSGEKKSVDFEFTMDSSNIEEFKEASPKNEIKENDENG
                     QQLPDWLRP"
     CDS             10844..11167
                     /locus_tag="ctg1_8"
                     /transl_table=11
                     /translation="MEKLVQVARLFDTYGSLLNEKQRDVINCYYNEDLSLNEIAQNNNK
                     SKQAISDMIQRSVDKLFEFENELSLLKKKDDLKDNLSLLRELIESSNENEAIKKIDQMI
                     NKI"
     CDS             11179..12516
                     /locus_tag="ctg1_9"
                     /transl_table=11
                     /translation="MIFSNLSEKLQDTLGKLTGKGKLSEKDIDNAAREIKLSLLEADVN
                     YKVVKNFIKKIKERSMGQDVMESLTPGQTVIKIVNEELTNLMGKENSKLELKGSTPHVV
                     LMVGLQGSGKTTHSGKLVRKLKKEGRNPLLVALDVYRPAAIEQLKVVGGQAEVEVFEKG
                     KQDPVKTANEAKEYARRNNNDVVIMDTAGRLQIDEDLMDELKNIKKAVKPDEILLVVDA
                     MVGQESVNVAKTFDDYLDITGVILTKLDGDARGGAALSIRQVVGKPIKFIGTGEKLDDL
                     EAFHPDRMASRILGMGDVLSLIEKAEKQVSLKDAKELEEKMRNQTYTLDDFIEQINQIR
                     NMGPLEDLLAMIPGVNNKMLKNVNVDEKGFVRIEALISSMTKEEREKPEIIGKSRKERI
                     AKGSGVDMNELNKLLKQFKELKKMMKQFTNMKKGRKGKRKFNMPFF"
     CDS             12535..12780
                     /locus_tag="ctg1_10"
                     /transl_table=11
                     /translation="MAVKIRLKRMGQKKRPFYRVVVADSRSPRDGKFIEEIGTYNPVSE
                     PKEFKIDNEKAKQWIKNGAKPTSIVEKLFNDNNVLA"
     CDS             12785..13009
                     /locus_tag="ctg1_11"
                     /transl_table=11
                     /translation="MKELVKLIVTELVENKDAVGIILEEDNGEVDIKINVAEADKGRVI
                     GKGGNIINSIRTIARACAVKEDVKVNIRI"
     CDS             13006..13491
                     /locus_tag="ctg1_12"
                     /transl_table=11
                     /translation="MKITVAEILTTHGIKGNLKIKSYSDNDKRFEKESKLFLDGNLVTI
                     ESSFKHKGNIIIKLKNYDDINDVEKFIGHELTIEDKDLEKLDNGEYYLFDLVGLKVYEK
                     NQELGFIKDVISGVYPNDIYVIEKDGKEVYLPALNATIKNVDLENKKIEVENFKDYE"
     CDS             13484..14203
                     /locus_tag="ctg1_13"
                     /transl_table=11
                     /translation="MNKITILTLFPESFEFLKNYGVIGKAIEKGLIEINLVDIRDYSKD
                     KHNKVDDTVFGGAAGMLMKPQPIYDALIANKTSKSKVVYMSAAGEILNQKLAIKFADFE
                     DLVILCGHYEGIDARITNHYVDYEVSIGDYVLTGGEIPAMVLIDSLSRFIGGVVGKKES
                     LVTDSHYNGLLQYDEYTKPRNFNGYMVPKELYSGNHKLVDEWKKKSSLEKTKKVRRDLY
                     DRYIKEDHDGINQKNRK"
     CDS             14175..14522
                     /locus_tag="ctg1_14"
                     /transl_table=11
                     /translation="MELIKKIENEQLREDNPDFRVGDTVRVSYRIKEGDKTRLQDFEGV
                     VIKIKEGNLGKTFTLRRLSYGVGVERTFLYHSPRLEAFKIVRRGKVRRAKLNYLRGRQG
                     KAAKVKEKTNY"
     CDS             14606..15442
                     /locus_tag="ctg1_15"
                     /transl_table=11
                     /translation="MNINWYPGHMKKTKEEIINSLKLVDIVLEVIDARIPDSSRNPLIS
                     EITQKKDRIIIMNKTDLSDPNENEKWIKKFADNGIKAIKMNSKEKINTRQIYNTARGIL
                     EEKFKKNEEKNIENENIRMMVVGVPNSGKSTFINNIAKRKGARVGNRPGVTQQKQWIKT
                     NEKILLLDTPGVLWPKLEGNSGLHLSFTNAIKDEILNVEELCLKFLEFMKEFYPDNLKE
                     RYKIDPTSSAIEIYDQIGLKRGAIIRKGEVDYTRCANLIFNDFRSGKLGRITIEKA"
     CDS             15429..16061
                     /locus_tag="ctg1_16"
                     /transl_table=11
                     /translation="LKKPRYSEFNDEIKKQIHEKYDLIAGIDEVGRGPLAGPVVACAVI
                     MKKDSHIEGITDSKKLSKKKMKELYQKIIADSISYSFGYANNILIDKINIKQATRYAMK
                     NALNNLSVKPQIVLIDAERIDTDIKQLNIVKGDLYEYSISCASILAKVRRDKIMENFSK
                     IYPYYSFETNAGYGTKKHYDGLEKYGECPIHRKTFLRKFHQRQLSFI"
     CDS             16058..16414
                     /locus_tag="ctg1_17"
                     /transl_table=11
                     /translation="MKSKKRSIGDFGEDIAARYLEKKGYQILERNFLKSFGEIDIIAIK
                     DDILTFVEVKTRKNDNFKPASLDVDYYKQERIKKTAQAYLIEKDLGDFLISFDVCEVYL
                     EEKMIHYIKNAFGD"
ORIGIN
        1 attaggttaa aacagtatat taaatatgtg gtgacgatgg cagaagggat acacctgttc
       61 ccataccgaa cacagaagtt aagccttcta acgccgatgg tactcggagg gagacctccc
      121 gggagactag gtagttgcca aacttatata atatcttcta tttttattag atagaaggta
      181 tttgtataag atttttttta ttattttatt gttttggagt gcttaggtag ctcaatggtg
      241 gagcacccgg ctgttaaccg gtaggttgtg ggttcgagtc ccaccctgag cgccaattat
      301 tattctatta attggaataa ttttaacaag atgctcatac taagaatact atatcgcggg
      361 atggagcagc ttggtggctc gtcgggctca taacccggag gtcgtaggtt caaatcctac
      421 tcccgcaacc atgtggcgaa gtagctcagt tggctagagc attcggttca tacccggagt
      481 gtcaagagtt caagtctctt cttcgctacc attttttatt ttttataagc tcttagctta
      541 ttgtatttgc ctggagcttt tggctccatg gtcaagtggt taagacacca gcctctcacg
      601 ctggtatccc gggttcaaat cccggtggag tcaccacgtt ttattatttt tatggcccta
      661 tggtcaagcg gttaagacat cgccctttca cggcggtatc ccgggttcaa atcccggtag
      721 ggtcaccatt ttggaagtat agctcagttg ggagagcatc tgccttacaa gcagggggtc
      781 acaggttcga gccctgttac ttccaccaat tatctttgtg gcttagtagt tcagttggtt
      841 agaatgctgc cctgtcacgg cagaggtcgt gggttcgaat cccatctaag tcgccattgc
      901 ctttaaggct attataggat ttggatttca gatgagatcc aatttgctga tgtagctcaa
      961 ttggtagagc aattgatttg taatcaatag gttgtaggtt caagtcctat catcagctcc
     1021 atattaaagc tttgctttga tattataatt tttcatattt acttaaataa acgggaagat
     1081 gttttaaact ttcataaatt ttcttcccac aaatatatgc ggaagtggct cagtggtaga
     1141 gtatcgcctt gccaaggcga gggtcgcggg ttcgaatccc gtcttccgct ccaataatgt
     1201 tttttgcggg tgtagctcag tggtagagcc ccagccttcc aagctggttg cgagggtccg
     1261 attcccttca cccgctccaa atttaaaaac ttatgagctg attaaagttc gtaagttttt
     1321 ttatgtgaat atttaattta tttatattag agattaatta aataaatttt tatacaattt
     1381 ctttttattt tttttatttt atggtacaat atataccata gtagaaattg atatttaata
     1441 aactactatt aaaaattgtt ttatattaat gtgcgcctgt agctcagctg gatagagcaa
     1501 cggacttcta atccgtgtgt cagaggttcg actcctctca ggcgcgccaa aatatcttta
     1561 taaattttta atgtgcgcct gtagctcagc tggatagagc aacggacttc taatccgtgt
     1621 gtcggaggtt cgactcctcc caggcgcgcc atatttttaa attttgagcg gtattagctc
     1681 agttggatag agcgactggc tacggaccag taggcctggg gttcgaatcc tcaatgccgc
     1741 gccattttga tctttagttt tctaaagatc tttttttgta tatttttttg tattttgaat
     1801 ataaaaaaag cacaaatttt attgtttgtg ctttgatatt attttatttt attttatttc
     1861 tacacttgga ttgtcttttg ttatgaagtg aatttcaaca tttccttcta aatgattttc
     1921 tagattttct gctagatagt taattgcatt tcttaagtct tcttttcttt ctgtatctag
     1981 attttccata aagagtatgg cattttttgt ttgatctgta atcattgttc tttgaccatc
     2041 tctccaatta aaacatctac aaactgcacc tttatcatct ctataacata attcaccttc
     2101 tagtgttggt gagtttttgt catcacctat agcttggaaa ggatcgtctc cttcagttat
     2161 ttcaagtttt aagtctccta caaatttatc aatatcttca gctccacatg gaagagcata
     2221 gtttaaagaa gtagcattgt aaatatcaac tagtggattt atacttccta catctttatc
     2281 ttttgaaact ctttttagta gtgcttctat tgagcaacga gctccttttt ttgttttaaa
     2341 tttacgaaat gcatctctcc aaacttttat aactggattt tcgctaaaaa ctggttttgt
     2401 aagatagtct aatgcttttt cgtttgcatc atcaagttta tctcttattt ctctgtttga
     2461 tttttcttcc atttttatat ctttaaataa gataagtcca atttcagctt caggaaataa
     2521 ttcccaaaat gattcacttg ctataaactc catattaact ccttttcata atttacttat
     2581 attatatttc cttcagaatc ttggtaattt atacttgacc taaatttatt aggtgatata
     2641 ccagtaagcc taccaaatga tctttggaag gttctagtag aattgtaccc gactttcatt
     2701 gctacatcta tgatttttag atcagttgtc tttaataatt cacatgcttt agaaattcta
     2761 agctcatcta agtattcata gaagtttttt tcaaattgaa aatatataag cctattgact
     2821 tcagatgttg agattccaaa agttttagca acttttccaa tagttaagtt tgcatcatta
     2881 aagttattta tttcgtagtt tacaacatca actaacaatt tttgctctga ttgttttaga
     2941 ctcatttgtt ttatattgta gtatttctta aattcaccag gttttattcc ttctgtgctt
     3001 tcaaaaattt ttgtaaaatg agaggagtct gtataaccaa cacttttagc tatttcagtc
     3061 aaacttttgt ctgaaaacat gagtaggtca attgcttttg aaaatctaat cctatttaaa
     3121 agttcagtaa aagtaaaacc agtattttca tctatatatt ttgttaaagt cgatttgctg
     3181 atgaaaaaag ttgatgatag tctgtctaag gtaagttttt cgctcatatg agaataaata
     3241 tacctaagaa tttgattgat ttttacttgc tgatcaaaac ttatatctgt tttaatttta
     3301 catttatttt cgaatcttaa aaatttaatt aaaattctaa taatagatga tataagaaat
     3361 tcatctgaat attctttttt tgtaatctct tcttggtagg aatcattacc tacttcgtct
     3421 ttaatttcaa taaaagaact ttccatatta taatatgatt cattatcaag aatttttata
     3481 ggatttttgg ataaaaattc tattgaattt atttgatttt tcctaaaatt acaaatattt
     3541 cttaaatcat cattaattat ttgaaaatta tatacaattt tataaaattc taaatcttca
     3601 gtaacatcag ttattgttgt aatatcccat ggtaatattg aaatcatagt gtttttttca
     3661 ataagatatt caactccatt gatcataaat ttacccttac ctcttttaat taaaagaagt
     3721 cttgccgtac tgtgtataag ggtagtagta gatttatctt gaaattcaac ttcaaaacta
     3781 caaatctttg acaagtctga aattgtagaa attttggttt gtatattact tataaccata
     3841 aacaacctct ttatataaat attctatact tatattatat agtattttgg tcgagattac
     3901 taattttaag ccgtttatta ataaattttc ataatttagt gtatgaaaat cttttcattt
     3961 aaatagagaa tacaataaag tatgtaaaat ttgtcgcgaa atttatattt aaaagtgtat
     4021 actattaatg taaacgatat tagtgctaat taatagttag aaaataacat aataaactta
     4081 tattaagcac tgtgttttat atattttagg aggaagcatg acaagtatac aagtaacaag
     4141 tgagattaaa ccacttaaaa aagttttggt acacagacca ggtgaagaat tattaaattt
     4201 aacaccatct actctagaag aattattgtt cgatgatata ccagatttaa aatctgctca
     4261 agaagaacat gacagattca cagatatcat gagagacaat ggtgtagaag ttgtttatct
     4321 tgaagattta atggctgaaa cattagatgc taatgatgga ttaagagaaa ctttcttaga
     4381 agaatattta agtgaaacag gttgtgaaga taaggatatt ctagctaaag ctaaagaata
     4441 tttagaaaaa attgaagata caaaagaatt tgttgaaaaa acaatggctg gtttaacatt
     4501 aaaagaacta ggtctattta cagaagaaga tcttcatgaa atggtggtag gacaatcata
     4561 cctagcaatt aatccaatgc caaatcttta ctttacaaga gatccattct catcagtagg
     4621 aaatggtgca gtaattaata aaatgtattc tgtaacaaga aacagagaaa caatctactg
     4681 tgactatatc tttagattcc atccagaata taaagaagtt ccagatcttt atggtagaaa
     4741 aaatgaattc catattgaag gtggagatac attcaatggt aatgaaaata cattattaat
     4801 tggtatttct caaagaactc aatacgatgc tatcaaagta ttagctaaaa atttattctt
     4861 tggtgatgtt gaaaacaaaa ttgaaaaaat ctatgcatta aaaattgatg aaaatagagc
     4921 tttcatgcac ttagatacag tatttacaca aattgattat gatgctttca cataccatcc
     4981 tgcaattatc aaagaaatgg aagttaaaat cataacaaaa gatgaagaaa ataatgattt
     5041 acacattgaa acagcatcag gaaaattaga tgaaatctta gcagaagctt taggaattga
     5101 aaaagttcgt ctaattccat gtggtggtgg agatccaata gctgcagaaa gagagcaatg
     5161 gaatgatgga tcaaacacat taacacttgc tccaggaaaa gttttagttt ataagagaaa
     5221 cactgtaact aatgaagtac taagaaaaga aggaattgaa gtgcttgaat tggaagcatc
     5281 aaacttaaca gtaggtcgtg gtggtccaag atgtatgtca atgcctttag aaagagaatt
     5341 ataagaagta agttagtcac taaaaattaa tattgaaaaa caaaaattaa ggagataaca
     5401 atatgccagt aaatttacaa ggacaaagta tattaggatt aaaattccta tcagaagatc
     5461 aaattaaata cctaatagat ctaggtgaac aattcaaaaa attaaaaatg acaagaacac
     5521 ctcataaata tctagaagga aaaaatatag tattattatt tgaaaaaact tcaacaagaa
     5581 ctcgttgttc atttgaagta gctggaatgg acttaggaat gggagtaaca tacctagatc
     5641 caggttcaag tcaaatggga cacaaagaat caatcgaaga tacagcaaaa gtattgggaa
     5701 gattctatga tggaattgaa tacagaggat ttgaccaaga attagttgaa aaattagctg
     5761 aacattcagg agtacctgta tggaatggtc taacagatga attccaccca acacaaatga
     5821 tagctgatat gctaacaatc aaagaaaact ttggttacct aaaaggactt aactttgtat
     5881 tcatgggtga ttgcagaaac aacgtaagta actcattaat ggtagcttgc gctaaacttg
     5941 gaatcaacta cacaggttgt ggtccaaaag aattatgggc agatgataaa ttagttgaag
     6001 aagctaaaga atttgcaaaa gttcacggat caaaagtaga atttacagaa gatgtagaag
     6061 aagcagcaaa aggcgctcat gcagtttata ctgatatttg ggtatcaatg ggagaaccaa
     6121 aagaagtttg ggaaaagaga attgaaattc ttcacccata ccaagtaaac caaaaagtta
     6181 tggacttagc agatgacgat gctatattct tacattgtct accatcattc cacgatcttg
     6241 aaacaacaac aggaaaagac gtgaaagaaa aattcggaga caaatacgat cttgacggaa
     6301 tggaagttaa agacgatgta ttcttaggaa aacaaagtaa agtatttgat caagcagaaa
     6361 acagaatgca tacaatcaag gctattatgt atgcaacatt aaaatagtaa aaaataaaat
     6421 agtaaatagg ataacaaatg acaaaaaaaa gattagttat cgctctcggg ggtaatgctt
     6481 taggcaatac ccctgctgag caattagaat tagtaaaaaa aacagcaaaa acaatagttg
     6541 atttatcaga aaactacgac atagcagtag gacatggaaa tggtccacaa gtaggaatga
     6601 taaataatgc aatggaattt tcagcaaaca agggtggaga tactcctgaa atgccatttc
     6661 cagaatgtgg agctatgagc caaggttata ttggatatca tttatcacaa tctataagaa
     6721 atgaattaaa aaatagaaat aaagattcag aaattgcttg tgttgttact caagtaatgg
     6781 ttgatgaaaa tgatgaggct ttcaataaac caacaaaacc aattggaagt ttcttaacaa
     6841 aagaagaagc agaagcgaaa caaaaagaaa atggttatga atatgttgaa gatgcaggaa
     6901 gaggatatag aagagttgta gctagtccaa ttcctaaaga aataattgaa atcaatattg
     6961 tagaaaattt ggttaataac ggtaacatag taataacagt cggtggaggt ggtgtgccag
     7021 taatcgaaac agaagaagga ttagaaggtg tgccagctgt aatagataaa gatagatctt
     7081 ctgcattact agcacaagag ctaaatgctg atatgttagt aatcttaaca gcagtagata
     7141 gagttatgat aaattacaac aaaccaaatc aagaagaaat agaagaaatg actgttgaag
     7201 aagctaaaaa gtatattgaa gaaggacatt ttgcacctgg ttcaatgtta ccaaaagtag
     7261 aagcttgttt agaatttgtt gaaaaatcag acaaaggtcg tgcacttata acatctttag
     7321 aaaaagcagc tgaagcctta gaaggaaaga caggaactat aattaaaaaa taggagaata
     7381 ctatgaaaaa agagaagaaa aaatcactaa gtgcattttc tatcttgatg attgtcctag
     7441 ctgcagtatg tttgattaca tttataacaa gtggtaaacc aatagattca gacataataa
     7501 aatctttaga tccaactaaa tacgaagatc ttattaacac tgtaaaagca ggggaaacag
     7561 ttactgttga aagtgcaaaa ttaagcgatt ttgtaatggc aataccaaat ggatttatgg
     7621 atgctgccga tcttattgta tttattttat gtattggtgg ttttattggt atcgtaatga
     7681 gcactggtgc aatggaagct ggaattcgtt cattagttag aaaaaataaa ggaaaagaag
     7741 gaagactaat tgcagtatta atgttcttat tctcagtagg tggttctact tatggaatgg
     7801 cagaagaaac aattggtttt tatccattaa ttacagcagc aatggtagca gcaggacttg
     7861 atactatggt tgcggtaggt acagttttac ttggagctgg agccggagta ctcggttcaa
     7921 caataaaccc atttgctaca tcagcagcta tgggagcttt ggaatcagta ggtataaaat
     7981 ctaatgccac aattgtaatg gttattggtg ttatactttg gttatcaaca gatattatag
     8041 ttattaaatt tgtattaaat tatgctaaaa aattattatc aaataaagag gcgtcagtat
     8101 taacagcaga tgaaaaacat gatatgcaag aatattttgc taaagatact gaaggagacc
     8161 ttgaatttac aggaactcat aaagcagtac taacaatttt tgctattaca tttgtaataa
     8221 tgattgcatc attaatttca tatgtagaca taaacttcaa aggtgatgaa gaagcatatc
     8281 taaaagtatt tggatggtca gatttcttga caggatcacc attaggatat tggtacttta
     8341 aagatcttgc ggctttattt acactttcaa gtatagtaat agcaattgtt gctaaaatta
     8401 gtgaaaaaga atttgtagat ggatttatag caggagcagc tgatctatta tctgtaggac
     8461 taataatcgc agtagcaaga ggaattacag tagtaatgag ctcaactcac ttagatttct
     8521 acattctaca aaactcagct aaattattaa aaggagtatc accatttgta tttgcaccac
     8581 ttgcttactt gatttacatg gtattatcat tcttggtacc atcaacatca ggacttgcag
     8641 cattatcaat tccaatcatg ggatcattgg caaatcaatt aggttatgac cctaatatta
     8701 tgattatgat tttctgtgca gcttgtggac ttgtaaactt tgttactcca acatcaggag
     8761 tagtaatggg tggtcttgca gcagcaaaag tagaatattc aacatatttg aaatgggtaa
     8821 gaaagccatt tattattgta tttattgcaa atataattat tttatcaatt gcaatgtcag
     8881 taatgtaaaa ataaaactca gatttttatc tgagtttttt taatgccaat tattatttaa
     8941 tacatcttta aatataaaaa ttttgatact tagattgata aaaaaagact taaaaaaatt
     9001 ttgtatttaa aaaaaattat gttataatta tattagttaa agagataaaa catttcttta
     9061 ttatgttaaa tatttatttt tatgtgcgcc tgtagctcag ctggatagag caacggactt
     9121 ctaatccgtg tgtcagaggt tcgactcctc tcaggcgcgc cattattttg cggtattagc
     9181 tcagttggat agagcgactg gctacggacc agtaggcctg gggttcgaat cctcaatgcc
     9241 gcgccaaact aagcttgaat cttcaagctt tttttattta caaaattttg ttcaataatt
     9301 aaaatgtttt gatatattta tataaaataa gagagttaga taagttagaa aataattata
     9361 aaaattatta caagtatcat gtaatttgaa atttgtttat aacatattat ttacattttt
     9421 ttgtagaata ataatataaa gatataaagg aggcatatat gtctagaaga aacaaaggat
     9481 ctggaggatt ttctaatttt ctttcaggat taattggtgc tgttctaggt ggatttttag
     9541 ttttttcatt actaggtagt tctattaata atggaaatag taaaaattct tcaaataata
     9601 attcgaaaga aaaaaataaa agcgtaataa acattgatac aagtgatgat attacaatgg
     9661 aaagggctgt tgttaaaaaa agtatagatt ctgtagtagg aattacgaca aaaacaaaag
     9721 caactcaaaa tactatattt ggtcctcaaa caggctacgt tgagggggta gggtcaggtt
     9781 cgattgtaac taaggatggt tatattttga ctaattccca tgtagtaagt aatggtgatg
     9841 ctagtgaaat taatgtatta ttttcaaata ataaatcgct aaaagcagag cttgtttgga
     9901 atgatacaac cttagatctt gctgtaataa aagtaaatgc taataattta aacccaattg
     9961 atttgggcga tagtgatgag ataaatgttg gcgatagagc tgtagctatt ggaaatcctt
    10021 taggacttga attacaatca acagtaacta gcggtattat ttccggttta aataggactg
    10081 tttcatttga aaatggcgca caaatggatg gtctaatgca aactgatgca gctatcaatg
    10141 cgggaaattc cgggggagcc ttgttaaatt ctaaaggtga attaattgga ataaatactg
    10201 caaaagcagg aaattctgat ggaattggat ttgcaattcc cgtaaattta gccaaaaaag
    10261 ttgtagatca aatttcaaaa aatggaaaat tcaactcagt ttatttagga attactggaa
    10321 taaatttaga tttattatta caatctaata atattgatcc aaaaaatgta ggaagcgaag
    10381 atggagttta cgttcaatca gtagttgacg atgctaaaaa ctactttaga aaaggagata
    10441 taattgtagg aattgacggt caaaaagtaa aagatatgtc aagtctaaaa aaactcttat
    10501 taaattacag cgttggtgat aaggctaagg ttgaaattgt tagaagtggt gagaaaaaat
    10561 cagtagattt tgaatttact atggattctt caaatataga agaatttaaa gaagcaagcc
    10621 caaaaaatga aataaaagaa aatgatgaaa atggtcaaca actaccagat tggctaagac
    10681 cataaataaa aaaagaattc cattttggag ttcttttttt gtatctgaaa taagggataa
    10741 aagttgaaat ttaaataaaa aaattgtcaa gaaaatttct tgacactagg gattttttct
    10801 agtatacttt ataggtcaag aaaattactt gacgggtgag aatatggaaa aattagtaca
    10861 ggttgcaaga ttgtttgaca cttatggatc tcttttgaat gaaaagcaaa gagatgtcat
    10921 aaattgttat tacaatgaag atttatcatt aaatgaaata gcccagaata ataataagtc
    10981 aaagcaggcc atatcagata tgattcaaag gtcggttgat aagttatttg agtttgaaaa
    11041 tgagctctct ttattaaaga aaaaagatga tttaaaagat aatttgtctt tgttaagaga
    11101 gttgatcgaa agttcaaatg aaaatgaagc tattaaaaaa atagatcaaa tgataaataa
    11161 gatttaggat gtgaaaatat gattttttca aatctttctg aaaagttaca agatacttta
    11221 ggtaaactta caggaaaagg aaaattaagc gaaaaagaca tcgataatgc agccagagaa
    11281 ataaagcttt ccttgcttga agctgatgtt aactacaagg tagttaaaaa tttcatcaaa
    11341 aaaatcaagg aaagatcaat gggtcaagat gtcatggaat ctcttacccc aggtcaaact
    11401 gttattaaga ttgtaaatga agaacttaca aatcttatgg gtaaggaaaa ttctaaactt
    11461 gaactaaaag gatctacccc tcatgttgtt ttgatggtag gtttgcaagg ttctggtaag
    11521 actactcact ctggtaagct tgttcgtaaa ttaaaaaaag aaggaagaaa tcctctttta
    11581 gtagctcttg atgtttatag acctgctgca atcgaacaat tgaaagttgt aggaggtcag
    11641 gctgaagttg aagtttttga aaaaggaaaa caagatccag taaaaacggc aaatgaggct
    11701 aaggaatatg ctagaagaaa taacaacgat gttgttataa tggatactgc tggacgtctt
    11761 caaattgatg aggacttgat ggatgagcta aaaaacatta aaaaagctgt taaacctgat
    11821 gaaattttat tggtagttga tgctatggtt ggtcaagaat ctgtaaacgt agcaaaaact
    11881 tttgatgact accttgatat aacaggtgta attttaacaa agcttgacgg tgatgcaaga
    11941 ggtggagcag ccctttcaat tagacaagtt gtaggaaagc caattaaatt tattggaact
    12001 ggagaaaaac ttgatgatct tgaagccttt catccagata ggatggcatc aagaattttg
    12061 ggaatgggag atgtcttatc tcttattgaa aaggcagaaa aacaagtttc tttaaaagat
    12121 gcaaaagaac ttgaagaaaa gatgcgaaat caaacctata ccttagatga ttttattgaa
    12181 caaataaatc aaataagaaa tatgggaccg cttgaagatt tacttgctat gattcctgga
    12241 gtaaacaaca agatgttaaa aaatgtaaat gttgatgaaa agggatttgt aaggattgaa
    12301 gctttaatat cttctatgac caaggaagaa agagaaaaac ctgagataat tggcaaaagt
    12361 cgtaaagaaa gaattgccaa gggatctggg gttgatatga acgaattaaa taaattatta
    12421 aagcaattca aagaactaaa gaaaatgatg aaacaattta ctaatatgaa aaaaggtaga
    12481 aaaggtaaaa gaaaattcaa tatgcctttc ttctaaaaaa atacggaggt tatgatggca
    12541 gtaaaaatta gattaaaaag aatgggacaa aagaaaagac cattttacag agtagttgta
    12601 gcagattcta gaagtccaag agatggaaaa ttcatcgaag aaattggaac atacaatcca
    12661 gtatctgaac caaaagaatt caaaattgac aacgaaaaag ctaaacaatg gataaaaaat
    12721 ggtgcaaaac caacatcaat agttgaaaaa ttatttaacg acaacaacgt tttagcataa
    12781 gaaaatgaaa gaattagtca aactaatagt tacagaactt gtagaaaaca aggatgctgt
    12841 aggaataata ttagaagaag acaacggaga agttgacatt aaaattaacg ttgcagaagc
    12901 tgataaggga agagtaattg gaaaaggtgg aaatataatt aattctataa ggactattgc
    12961 tcgtgcttgt gcagtaaaag aagatgttaa ggttaatata agaatatgaa aataactgta
    13021 gcagaaatac ttacaacaca tgggataaaa ggaaacctta aaataaaatc ttattctgat
    13081 aatgataaaa gatttgaaaa ggaatctaaa ctttttcttg atggaaattt ggttacaatt
    13141 gaatcatctt ttaagcataa gggtaatatt atcataaaac tcaagaacta tgatgatatt
    13201 aatgatgtag aaaagtttat tggacacgaa cttactatag aggacaagga cttagagaaa
    13261 ttagataatg gagaatatta tttatttgat ttagttggac taaaagttta tgaaaaaaat
    13321 caagaacttg gttttataaa agatgtgata tcaggagttt atccaaacga catctatgta
    13381 atagaaaaag atggcaagga agtttatctt ccagccttaa atgctacaat taaaaatgtt
    13441 gacttagaaa ataaaaaaat agaagtggaa aacttcaaag attatgaata aaataactat
    13501 acttacactt tttccagaat ctttcgaatt tctaaaaaac tatggagtta taggaaaggc
    13561 aatagaaaaa ggactaattg aaattaatct tgttgatata agagattata gcaaggacaa
    13621 acacaacaag gttgatgata cagtctttgg tggagcagca ggaatgctaa tgaagcctca
    13681 gccaatttat gatgccctaa tagcaaataa aacttcaaaa tcaaaagtag tctacatgtc
    13741 tgcagcagga gaaatcctaa accaaaaatt agcaatcaaa tttgcagatt ttgaagactt
    13801 ggtaatactt tgtggtcatt acgaaggaat tgatgcaaga attaccaatc actatgttga
    13861 ttatgaagtt tcaattggag attatgtttt aacaggtggt gaaatccctg ccatggtgtt
    13921 aatagattct ctatcaagat ttattggtgg agttgttgga aaaaaagaat cattagttac
    13981 agattcacac tacaatggtc tactacaata tgatgagtac acaaaaccaa gaaatttcaa
    14041 tggatatatg gttccaaaag aactttatag tggaaatcat aaattagtag acgaatggaa
    14101 aaagaaatca tctcttgaaa aaactaaaaa agtaagaaga gatttatacg atagatatat
    14161 caaggaggat cacgatggaa ttaatcaaaa aaatagaaaa tgaacaacta cgtgaagata
    14221 atccagactt tagagttgga gatactgtaa gagtaagcta cagaatcaaa gaaggagaca
    14281 aaacaagact ccaagacttt gaaggtgtag taatcaaaat aaaagaagga aatcttggaa
    14341 aaactttcac acttagaaga ctttcttatg gtgtaggagt tgaaagaaca ttcctttatc
    14401 actcaccaag acttgaagca tttaaaattg taagacgtgg taaggtaaga cgtgcaaaac
    14461 taaattacct aagaggacgt caaggtaagg ctgcaaaagt taaagaaaaa acaaattatt
    14521 aataagaaga ccccaaaggg tcttttttat tttataaatt cacaaatatt tgtgataaaa
    14581 tataagataa agattaggag gatatatgaa tataaattgg tatccgggtc atatgaaaaa
    14641 gaccaaagaa gaaattataa attctctaaa gcttgttgat atagttttag aagtaataga
    14701 tgcaagaatt ccagattcat ctagaaatcc gttgatttca gaaataaccc aaaaaaaaga
    14761 taggattata ataatgaata aaactgacct atcagatcct aatgagaatg aaaaatggat
    14821 caaaaaattt gcagataatg gaattaaagc tataaagatg aattctaagg aaaaaattaa
    14881 tacaaggcaa atttataata cagctagagg aattttagaa gaaaaattca aaaaaaatga
    14941 agaaaaaaat atagaaaatg aaaatatcag gatgatggtt gttggtgttc caaattctgg
    15001 gaaatctacc tttattaata atattgccaa aagaaaggga gcaagggttg gaaatagacc
    15061 tggagttacc caacaaaaac aatggataaa aacaaatgaa aaaattttac ttttggatac
    15121 tccaggtgtt ttgtggccaa aacttgaagg aaattcagga ctgcacttat cttttaccaa
    15181 cgcaattaaa gatgaaattt taaatgttga agaattatgc ctaaaatttt tagaatttat
    15241 gaaggaattt tatccggata atttaaaaga aagatataag atcgatccta ctagctcagc
    15301 tatagaaatt tatgatcaga ttggcttaaa aagaggagcc ataattagaa aaggcgaagt
    15361 tgattataca aggtgtgcaa atttaatttt caatgatttt agaagtggaa aacttggaag
    15421 gataacaatt gaaaaagcct agatattctg aatttaatga tgaaattaaa aaacaaatac
    15481 acgaaaaata tgatttgatt gcaggaattg atgaagttgg aaggggaccc ttggcaggtc
    15541 ctgttgtagc ctgtgcagta attatgaaaa aagattctca tatagaaggg attactgatt
    15601 ctaaaaaatt atccaaaaaa aagatgaaag aactttatca aaaaattata gctgattcaa
    15661 tttcttattc ttttggatat gcaaataata ttcttattga taaaattaat ataaaacaag
    15721 ctacaagata tgctatgaaa aatgctctca ataatctttc agtaaaacct caaattgtat
    15781 tgattgatgc tgaaagaatt gatactgata tcaagcaatt aaatattgta aagggtgact
    15841 tgtatgaata ttccatctct tgtgcatcaa ttcttgcaaa ggttcgtaga gataaaataa
    15901 tggaaaattt ctcaaaaatt tacccttatt attcttttga aactaatgca ggatatggaa
    15961 caaagaagca ctacgatgga ctagaaaaat atggtgagtg cccaattcat agaaaaactt
    16021 ttctaagaaa atttcatcaa aggcagctat cttttatatg aaaagtaaaa aaagatctat
    16081 aggagatttt ggggaagata tagctgcaag atatttagag aaaaaaggct atcaaatttt
    16141 agaaagaaac ttcctaaaat cttttggtga aattgatatc attgcaataa aagatgatat
    16201 tttgaccttt gttgaagtaa aaactagaaa gaatgataat tttaagcctg caagtttgga
    16261 tgttgattat tataaacaag aaagaatcaa aaaaacagcc caagcttatt taattgaaaa
    16321 agacttgggt gattttttaa tttcttttga tgtatgtgaa gtatatcttg aagaaaagat
    16381 gattcattac ataaaaaatg catttggtga ttagatgaaa aagaaagaat tactattata
    16441 ttttaatttt ataaatttat ccaacaagat aattttggat ttttgtgaaa atcttgatat
    16501 ggatgatttt tttgaccttg ataggaaaat ctttgataaa ttgactaaga aaaatagaga
    16561 aaagattttt tctaagaaaa atttagaaga ttttaaaact tataaggaaa aagttatcaa
    16621 aggaaattac aaaatttgta ctatttatga tgaaaattat ccgataaatt tatcctttat
    16681 agacgataag ccaactcttt tttattacaa gggaaaaatt gaaaaagaag acaaaaatgc
    16741 ccttgccttt ataggcgcta gaaaatgtac agactatggt aaatgggcat gcaaaaaaat
    16801 cgttgaagga tttaaagata caaatataag gacagtttca ggacttgcct atggaattga
    16861 tgcaataagc cataaggtaa gccttgaaaa taatataaaa acaattgggg taattggctc
    16921 aggtcttaat atagtttatc ccaaggcaaa taaatatttg tatgaaaaaa ttgaagaaaa
    16981 tggcttaatt atttcagaat ttcccttaga aactccacca aattcctata attttccaag
    17041 aagaaatagg attatatcag gacttagcaa gggagtttgt gtgattgaag caaaagaaaa
    17101 atctggaact atgattacaa caaattttgc ccttgatcaa ggaagggaag tgttttgtct
    17161 tcctggaaat ataaattcaa tttattcaaa aggttgcaat aaattaattc aagaaggatc
    17221 aaagcttgtt atggatgcat ctgatataat agatgaaatt gaagatttta aaaatataaa
    17281 taaggaaaaa agaaaaataa atcttgatgg acttgataaa gatgctgcaa atgtagtaaa
    17341 gtatataatc gacaagccat cttcaagtgc aga
//
