LOCUS       NZ_KE384518.1          15267 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_KE384518.1 Anaerovorax odorimutans DSM 5092
            K292DRAFT_scaffold00003.3, whole genome shotgun sequence.
ACCESSION   NZ_KE384518
VERSION     NZ_KE384518.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-03-13 23:35:14
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 260922
            Orig. end    :: 276189
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15267
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[270922:275801]"
                     /cutoff="2000"
                     /detection_rule="(Complex1_51K and minimum(5, [FMN_bind,
                     FeS, Fer4, Fer4_9, NQR2_RnfD_RnfE, Rnf-Nqr, RnfC_N,
                     SLBB]))"
                     /neighbourhood="10000"
                     /product="Rnf_complex"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..14879
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="2000"
                     /detection_rule="(Complex1_51K and minimum(5, [FMN_bind,
                     FeS, Fer4, Fer4_9, NQR2_RnfD_RnfE, Rnf-Nqr, RnfC_N,
                     SLBB]))"
                     /neighbourhood="10000"
                     /product="Rnf_complex"
                     /protocluster_number="1"
     cand_cluster    1..15267
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Complex1_51K and minimum(5, [FMN_bind,
                     FeS, Fer4, Fer4_9, NQR2_RnfD_RnfE, Rnf-Nqr, RnfC_N,
                     SLBB]))"
                     /kind="single"
                     /product="Rnf_complex"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15267
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Rnf_complex"
                     /region_number="1"
                     /rules="(Complex1_51K and minimum(5, [FMN_bind, FeS, Fer4,
                     Fer4_9, NQR2_RnfD_RnfE, Rnf-Nqr, RnfC_N, SLBB]))"
                     /tool="gutsmash"
     CDS             568..1758
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg3_244"
                     /sec_met_domain="Aminotran_1_2 (E-value: 1.1e-52, bitscore:
                     173.4, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISKKMVSYVESSSIIRAMFEEGKRLSDIHGAENVYDFSLGNPNT
                     QPPQAVKEAILDILNSESPTFVHGYMNNSGYEDVRDSIAKSINNKFNTDFNEKNIIMTV
                     GAAGGINVILKTLLDPGDEVIAFAPFFGEYRSYTSNFDGNLIVVSPNTKDFQPNLEEFK
                     NKITAKTKAVIINSPNNPTGVIYSEKTIIDMANILREKQLEFGADIYIIADEPYRELAY
                     DGINVPYVTKYYDNTIVGYSYSKSLSLPGERIGYLVIPNKVADFENVVSAANVANRILG
                     FVNAPSLIQRAVAKCVDAEVDIDSYNKNREALYNGLVSLGYECIKPEGAFYLFLKSPVE
                     DDKLFCEMAKKYNILMVPGTSFACPGYVRIAYCVAYDTIINSLPNFKELISEVKDK"
     CDS             complement(1831..3114)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Radical_SAM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LAM_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg3_245"
                     /sec_met_domain="Radical_SAM (E-value: 7.6e-13, bitscore:
                     43.2, seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="LAM_C (E-value: 6.3e-44, bitscore: 143.3,
                     seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTQLNLKKIDLINNNFFKNIDPEDWNSWSWQMQNRIETVEDLKK
                     HIDLTPEEESGIKKCLNTLRMAITPYYLSLINPEDPNDPIRKQAIPSSLEIMRDSFDIE
                     DPLHEEADSPVPGLTHRYPDRVLLLVTDQCAMYCRHCTRRRFAGQSDNSLPMEQIDKAI
                     KYIAKTPEIRDVLISGGDALLISDEKLEKIIKRLRAIKHVEIIRLGSRVPVVMPQRITP
                     KLVSMLKKYHPIWLNTHFNHPNEITFESKKACEMLANAGIPLGNQTVLLRGINDCVHVM
                     KKLMHELVKIRVRPYYIYQCDLSMGIKHFRTKVSKGIEIIEGLRGHTSGFAVPTFVIDA
                     PGGGGKIPVMPNYVISSAENKVILRNFEGVITTYNEPEDYSSECTCEVCSGKKDIEPVG
                     ISRLVNNEKISLEPSGLRRNIRNGNESE"
     CDS             complement(3163..3999)
                     /locus_tag="ctg3_246"
                     /transl_table=11
                     /translation="MYDSITNIDNSEIQYGSENNRIYLMHLAKEDMPDILIKLDLMADK
                     HGYTKIIAKVPKSVSEDFIKDGYAKEAEVLGYFKGKEDCLFMAKYMDKKRQSEVDKELN
                     KKVLDIAESKEIFDINKYHFSEEFSFRKANLSDVNKMAELYSKVFDSYPFPITEPEYII
                     ETMKTNVIYYGIFRGNKLLALSSCEMSLKDENVEMTDFAVLPEYRGYNFANFLLSNMEK
                     EMKKINIKTAYTIARSASYGMTITFAKGGYTYAGRLKSNTQIGGKIEDMSVWFKAL"
     CDS             4223..4864
                     /locus_tag="ctg3_247"
                     /transl_table=11
                     /translation="LSTIKNKTPRYIKIALDIARRIDNLEFKEGAKLRGRSTLASEYNV
                     SPETIRRSASLLEDMGVVIITQKSGIFIKSIKKARIFLEKFNEKNNLDETRNAIKQLRI
                     EKENIEKKIDENIDTLLEYFMQQKKINLGSSYEIPVPIQSNIIKKTINELQFWHNTGAT
                     ITAIKRDYELFISPGPYFEFIEGDIICFICTAENYYKVEDFVNKKAEILS"
     CDS             complement(4919..5545)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FTCD_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg3_248"
                     /sec_met_domain="FTCD_C (E-value: 1e-56, bitscore: 185.6,
                     seeds: 242, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLADLNIRKYNELLASSEPAPGGGAASALAGAQGIALSLMVINL
                     TIGKEKYKEFEPLCLDVKIKAEKLLEDLILGIDKDKDAFNLLSSAYKMPKDTIKEKVLR
                     SNAIIKTTIGATEVPLEAMQQGLEGLKLTYKLIGKSNKSAVSDLGVAALNLLSCVKGAW
                     LNVLINIPSIKDLNMAEDFKKRGQAIYTESEKLCEEIYNKVASSF"
     CDS             complement(5585..5965)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Ribonuc_L-PSP"
                     /gene_functions="regulatory (smcogs)
                     SMCOG1038:Endoribonuclease L-PSP (Score: 149.1; E-value:
                     1.8e-46)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg3_249"
                     /sec_met_domain="Ribonuc_L-PSP (E-value: 7.8e-46, bitscore:
                     149.1, seeds: 29, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRKIVSTKEAPAAIGPYSQGNIFGNLLFTSGQIPINPSSGEIVGK
                     TIEEQTEQVFKNVKAILEEAGSSLDKVLKTTVFIKNMDDFAAMNGIYAKYFKEGVLPSR
                     SAVEVARLPKDVLVEIETIAYV"
     CDS             complement(6038..6574)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) YcxB"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg3_250"
                     /sec_met_domain="YcxB (E-value: 4.4e-14, bitscore: 46.1,
                     seeds: 189, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIENNKIKLDFEIKKEDYKALSNFTLFFRKRWTIFAYVFIFVLAL
                     VMMIGRASGKLDMPDWYFYFYVIMIFFIILIFIIQELMIRRVLRTDKVSFHIKRQYIID
                     ENKIQIKGGKENRNSEYKWDLFYKGYETKKYFLLYVNIQQAFILPKKAMTEEEIIMTEK
                     ILKENMGRNFNKRCK"
     CDS             complement(6561..6854)
                     /locus_tag="ctg3_251"
                     /transl_table=11
                     /translation="MKKTSQKLNYVYLLRCKDGTLYGGWTNDLQSRIKAHNDGKGAKYT
                     RGRRPVTLVYSESFDTKEEAMKMEWKIKHMARAKKIKLIEEKGKGITINDRK"
     CDS             complement(6873..7439)
                     /locus_tag="ctg3_252"
                     /transl_table=11
                     /translation="MGEGYSKIFWGLFLTMFHINLGSIQLLPNFIGLLIVLNGIKQMLY
                     KYENIKELKNAVAFCYMSIIIEFIIFFIKLISYEGIALIFNLIIIELGIISDFIMIFYI
                     LSGAVRILERLELTIAANEYIKNIRIFTVLYSILCIILAISVSFNFEIIAVLSIIFWII
                     INIWLLIIIRGLKNLKIDDEVNYTI"
     CDS             complement(7440..8357)
                     /locus_tag="ctg3_253"
                     /transl_table=11
                     /translation="MELNFKIFKICITCIIFTAFICLGFIFCLRLDEPVFLKTYCEYEV
                     QEDVNDENHYEDTQFIIRYITNIDDKAKVTNVTFLEAPELDFWASEDKPNSSFVFSYNN
                     NENNVIGERCGTYSIRTVYVNLLSREDIFNDNSILELNNAEVMFSDGTSMNVQLGRLLF
                     SKKTNSTQLLTNDYSGSTSSEGSHISEEKYIVEKNLKLLSVNSPLFKETNELIELTIDG
                     NKFDKVNNIQYEKFDTIDVKSRFKDKLDTMSYYTMYDIKPVIAYEDDFGNTYELRIYNI
                     ERNTYNLECDFIKLIKYLKERGSI"
     CDS             complement(8467..9621)
                     /locus_tag="ctg3_254"
                     /transl_table=11
                     /translation="MVLERCREYSIPLILGVIISLIWTNVSIESYHHFIHTPIFFNIDF
                     HFLINDIFMVFFFAIAGVEILNSLSRGGALNPIRKAVTPLMATAGGVIGPIFTFFILNY
                     FFGSDEYINGWGICTATDIALAWLLARIVFGKKHPAVSFLLLLAVADDAIGLIIIAVFY
                     SDPTEPVKPLWLLLIVVGMLIAWTLNRKRVKSYVPYIFGAGTIVWIGMYAAHLHPALSL
                     VFIVPFLPKKGVSTELIDMHGVNDAPIHTTLNKFEHQISPLVDYGLIFFGISNAGVELS
                     QISKLTWIVFASLVIGKTIGISLFTCHAVLLKFKLPEGMRAKDVFLTGLIGGLGLTVAL
                     FVASEAYSDVSLQGSAKMGALFTIFLFIFVIALGKIMRIKKIDN"
     CDS             10001..11308
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: RnfC_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: Fer4"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: SLBB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: Complex1_51K"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_10"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg3_255"
                     /sec_met_domain="Fer4_10 (E-value: 1.1e-09, bitscore: 32.4,
                     seeds: 59, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 1.7e-07, bitscore: 24.9,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="SLBB (E-value: 2.6e-14, bitscore: 46.9,
                     seeds: 67, tool: rule-based-clusters)"
                     /sec_met_domain="Complex1_51K (E-value: 1.8e-49, bitscore:
                     161.6, seeds: 88, tool: rule-based-clusters)"
                     /sec_met_domain="RnfC_N (E-value: 1.7e-32, bitscore: 105.5,
                     seeds: 53, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 0.00017, bitscore: 16.1,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LSILKKHLQGIHVDHRKNTMNHAIETMPTPDIVYISMSQHIGAPC
                     EPLVSVGDHVKIGQPIGNSEAFISAPVHSSVSGKVTNIEEVMSSLGTMDKTIIIKTDKK
                     QELWEDIKIPTAETKEEFIKAIRDSGLVGLGGAAFPTHVKYNPRNLDEVDTLIVNGAEC
                     EPYITSDYRTMLEHTQDIVNGILLIMKHLELKQCYIGIEENKPEAIERLNSFLSTFPNI
                     KVITLDSRYPQGAERVLIYETTGKVLPPGKLPADIGVIVSNITSIAFLAKYFRTGVPLI
                     SKVVTVDGDAVSTPKNVRVPIGTKIYEVINFCGGYKKPPKKIIFGGPMMGRAIYDDGKP
                     IIKNNNAILAFDEDQALIPNETACINCGRCVQACPLNLMPTAIDKAYKRNDIDALKNLN
                     VAICMECGCCSYVCPAKKQLSLVNKLSKALVKEAGK"
     CDS             11310..12269
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: NQR2_RnfD_RnfE"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg3_256"
                     /sec_met_domain="NQR2_RnfD_RnfE (E-value: 7.6e-117,
                     bitscore: 383.8, seeds: 472, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNYKYDNLIVASSPHLVDSITTSKIMAMVIIALMPAFAVSIWVF
                     GARAIFLTGICIIACVVFEYLFNKITKKPSTIGDFSAVVTGILVAFNVPVNFPYWMAII
                     GCFVAIIIAKQLFGGIGQNFVNPAITARVVLFLAFSTEMTSWPTPQRIFLATDAVTGAT
                     PLALFAKQNFDQLPSNTEMFLGTIGGCIGETSALALLIGGLFLLFKKIISPTIPVSFLG
                     TMVVISLIAGIDPIFQICAGGAMIGAFFMATDYSTSPLTTNGKIIFGIGCGLITMVIRL
                     FGNYPEGVSFSILFMNLIVPHIDNLSRRKLYGGGVKND"
     CDS             12262..12816
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: FMN_bind"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg3_257"
                     /sec_met_domain="FMN_bind (E-value: 1.8e-23, bitscore:
                     77.0, seeds: 891, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKFKDYFAPTLVLMIICLCVTIALAVTYNITTPIIEASAAAEAS
                     ASRAEVLPSGKDGFTAFDVNYTEGIQDVYAADNNSGYAITSYNKGFGGKVYTMVGIDNK
                     GEITGIKVLSHSETPGLGTKAMTPEYLSQYISASKITLTNEPDATNIDTITGATISSKA
                     IYGAINNALVQYDELRGVKND"
     CDS             12809..13483
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: Rnf-Nqr"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg3_258"
                     /sec_met_domain="Rnf-Nqr (E-value: 1.8e-68, bitscore:
                     224.0, seeds: 650, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKLDLIKNGIIKENPVLVLLLGACPTLAVTTSAINGLGMGVSTM
                     TVLICSNIVISLLKSVISPKVRIPCYIVVIAGFVTMVGFLLNAYVPDIYDSLGLFIPLI
                     VVNCIILGRAEMFASKNSVLNSAADGIGMGLGFTLALFLMGAIREFLGAGTLFGFTITA
                     NIIKPMTIFALPPGGFFVFGCLVALINFISKGRAIKKTEMGCSNCPSAEACGKSEKGEC
                     NN"
     CDS             13483..14073
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: Rnf-Nqr"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg3_259"
                     /sec_met_domain="Rnf-Nqr (E-value: 1.1e-58, bitscore:
                     192.2, seeds: 650, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEILMIMFSVILVDNFVLTKFLGICPFLGVSKKLDSAVGMSGAV
                     IFVMVLATIVTYPIYIYILEPSGLKYLQTIVFILVIASLVQLVEISLKKYIPALHRSLG
                     VFLPLITTNCAVLGVTILNIDENYTYIQSIFNALGAGIGFLLAMVIFAGVRQKIEYCNV
                     PATFKGIPSILIAASIVSVSFMGFSGVVDGIFK"
     CDS             14085..14879
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: Fer4"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: FeS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1016:4Fe-4S dicluster domain (Score: 29.2; E-value:
                     3.6e-09)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg3_260"
                     /sec_met_domain="Fer4_7 (E-value: 4.8e-09, bitscore: 30.8,
                     seeds: 208, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 1.1e-09, bitscore: 31.9,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="FeS (E-value: 1.4e-13, bitscore: 44.3,
                     seeds: 364, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 0.002, bitscore: 12.8,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQQYFLPIIIVIIIGFLAGTILTLASKFMAVKVNETVVKVKEILP
                     GANCGACGYAGCEDYAVALANDPTIKPNLCTPGGSSVALAISNALGIEFEAVAGKTAVV
                     KCSGTYAKTNYVMDYRGLQSCAANKMFYRGRGACDYSCIGYGDCVDACEYDAIKIEGGV
                     AVVDNDKCVGCGLCAKRCPNNLIDIVPGSNFVYVGCSSNEKGAVTKDKCTIGCIGCKKC
                     EKICKFDAIHVINNLAVIDYDKCKNCKMCINECPVGVIKFNN"
     CDS             complement(14976..15266)
                     /locus_tag="ctg3_261"
                     /transl_table=11
                     /translation="FHSDQGWAYQMKAYSSNLKSNRIYQSMSRKGNCYDNSIMENFFGV
                     MKQEMYYGCVYYSYEELKDAIEKYIYYYNNQRIKQKLSWMSPVEYRLSQVA"
ORIGIN
        1 cattagataa tttcctattc cataaggcaa tgaagctatg ggaattaatg ggtaaaaaaa
       61 gaattgtgct ccgataacag caaaaacaac aacagggata aaataaaccc atttattatt
      121 ccccttcgta aatcttggat taatcatagt tcctacacat attccaacta aaaaataaac
      181 tatatataat actaagtata cgtatgatcc tgcacccaca agctgtgcat tcagccaagc
      241 ccctattatc ataagtatta atataagcag cactctgccg catattttta gcgttgcttc
      301 catagacttt ctccttattt acttattttt tagttattat aaaaaacctc ttttaaggct
      361 cttttatctc ttttaattct tattgcttcg taattattat gtttaattat accagatttc
      421 ttactatttt tatataagaa ttgttttttc caatataaga atgatataat aatataagtt
      481 atttattaat taaacttatt actattttaa gttatcataa tagtaatttt ataatataca
      541 aatgaaaata atttaggagt gtaaaatatg atttcaaaaa aaatggttag ctacgtagaa
      601 agcagctcaa taataagggc tatgtttgaa gaaggaaaac gtttatctga tatacacgga
      661 gctgaaaatg tatatgattt cagccttgga aatccaaata cacagcctcc tcaagcggta
      721 aaagaagcaa ttcttgatat tttaaacagt gaatctccta cctttgtaca cggttatatg
      781 aataactcag gttatgagga cgttagagat tccattgcta aatctattaa caataaattt
      841 aatactgatt ttaatgaaaa aaatattatc atgactgtag gtgctgccgg aggtataaat
      901 gtaattctaa aaaccctctt agacccaggt gatgaagtaa tagcctttgc acccttcttt
      961 ggggaatata gaagttatac ttcaaatttt gatggtaatt taatagtagt ctctccaaat
     1021 acaaaagatt ttcagccaaa tttagaagag tttaaaaaca aaataactgc aaaaacaaaa
     1081 gctgttataa ttaattcacc aaataaccct acaggagtta tatactcaga aaaaacaatt
     1141 atagatatgg caaacatttt aagagaaaaa cagcttgaat ttggtgcaga tatttatatt
     1201 attgctgacg aaccatacag agaacttgct tatgatggaa taaatgtgcc atatgtaaca
     1261 aaatattacg ataacactat tgtggggtat tcttacagta aatctctttc tctaccagga
     1321 gaaagaatcg gatatttagt tattccaaat aaagttgctg attttgaaaa tgtagtttct
     1381 gctgctaatg tggcaaatcg tatcctaggg tttgtaaatg caccttcact tatacagcgt
     1441 gcggttgcaa aatgtgtaga tgccgaagta gacatagact cttataataa aaacagagaa
     1501 gctttatata acggattagt atctttaggt tatgaatgta taaaacctga gggagcattt
     1561 taccttttct taaaatctcc tgtggaagat gataagttat tttgtgaaat ggcaaaaaaa
     1621 tataatattc tcatggtacc cggtacttct tttgcttgcc ccggttatgt aagaatagct
     1681 tattgtgtag catatgatac tattataaat tctctaccaa actttaaaga attaatatct
     1741 gaggttaaag ataaataatc attaaaataa tgtttagcat ttaaaagaga ctgcttttaa
     1801 acagtctctt ttattatatt tttaataagt ctattcactt tcattaccat ttcttatatt
     1861 ccttctaagc cctgatggtt ctaaagatat tttctcatta tttacaagcc ttgaaatgcc
     1921 tacgggttct atgtcttttt tacccgaaca aacttcacaa gtacactccg atgaataatc
     1981 ttccggctca ttatatgttg ttattactcc ttcgaaattt cttaaaatca ctttattctc
     2041 ggcactcgaa ataacataat ttggcataac gggaattttt cctcctccgc caggtgcatc
     2101 tattacaaaa gtaggaactg caaaacctga tgtatgtcct ctcagccctt ctattatctc
     2161 tatacctttt gaaactttag tcctgaaatg ttttataccc attgaaagat cgcactgata
     2221 aatataatac ggtctaactc ttatctttac aagttcatgc attaattttt tcataacatg
     2281 aacacaatca ttaatgcctc ttagaagaac agtttgattt cctaaaggaa ttccggcatt
     2341 agcaagcatt tcacatgctt tttttgattc aaaagtgatc tcattaggat gattgaaatg
     2401 tgtatttaac catataggat gatacttttt taacatggag acaagttttg gggtaatcct
     2461 ttggggcata acaacgggca ctctgcttcc taatcttatt atctcaacat gttttatggc
     2521 tcttaatctt ttaattatct tttcaagttt ctcatcagag attaaaagtg catctcctcc
     2581 tgatataaga acatctcgga tttcaggagt tttggctata tattttatag ccttatcaat
     2641 ttgctccata ggaagtgaat tgtcactttg acctgcaaat ctccttctag tacagtgcct
     2701 gcaatacatt gcacattgat ctgtaactaa aagaagaact ctgtcagggt atctatgtgt
     2761 aagtcctgga accggtgaat ctgcttcttc atgtaaagga tcttcaatat caaagctatc
     2821 tctcataatt tctaaggaac ttggtatcgc ttgttttctt ataggatcat ttggatcttc
     2881 aggatttata agagaaagat aatatggtgt tattgccatt cgtaatgtgt taaggcattt
     2941 ttttattcca ctctcttctt ctggggtaag atctatatgt ttttttaaat cttcaacagt
     3001 ttctattctg ttttgcattt gccacgacca actattccaa tcttctggat caatattttt
     3061 aaaaaaatta ttattaatta aatctatttt ttttaagttt aattgagtac tcataaaacc
     3121 tcctattcag tttttattta aaaattaact tattctataa atttataaag ctttaaacca
     3181 aacactcata tcttcaattt tcccgcctat ttgggtatta cttttaagtc ttcccgcata
     3241 agtatatccg ccttttgcaa aagtaatagt cattccgtag gatgctgagc gagcaattgt
     3301 atatgctgtt tttatattga tttttttcat ttctttttcc atattactta gtaaaaaatt
     3361 tgcaaaatta tagcctctat actccggtaa tactgcaaaa tctgtcattt caacattttc
     3421 atcttttaaa ctcatctcac atgaggaaag agccagcaat ttatttcctc taaagatacc
     3481 ataatatata acattggttt tcatcgtttc tatgatatat tccggttctg ttatagggaa
     3541 aggataggaa tcgaacactt tagaatataa ttcagccatt ttgttaacat ctgaaagatt
     3601 tgcttttcta aacgaaaatt cttcagaaaa atggtattta tttatatcaa atatttcttt
     3661 tgattcagca atatctaaaa cttttttgtt taattcttta tctacttcac tttgcctttt
     3721 tttgtccatg tattttgcca taaacaagca atcttctttt cccttaaaat aacccaaaac
     3781 ctcagcttct ttagcatatc catcttttat aaaatcctct gatacggatt ttggaacttt
     3841 tgcaattatt tttgtatatc catgtttatc tgccattaaa tcaagtttta ttaaaatatc
     3901 aggcatatct tcttttgcaa gatgcataag atagattcta ttattttcag atccatattg
     3961 tatttcagaa ttgtctatat tagttatact atcgtacata atttccccct tttgtaaata
     4021 ttcttcaatc tgacaacttt attatatcat aaaagttgtc agatgtaaaa tttttatgat
     4081 attaatttta aattaagcct tacgtatttt taattaatat tctcaaatat acttttatat
     4141 atgttctggc ttacatatct tgacagtaca tgcttttatg ataaaatgag attaatattg
     4201 taatatgaaa gagggataat tgttgagtac aataaagaac aagacaccga ggtatatcaa
     4261 aattgcactt gatatagcaa gaagaatcga taatcttgaa tttaaagaag gtgcaaagct
     4321 aagaggaaga tccactttgg caagtgaata taatgtatca ccggaaacaa taagaagatc
     4381 tgcttcgctt cttgaagaca tgggtgttgt tataataacc caaaaaagcg gcatatttat
     4441 taaatctatt aaaaaagcta gaattttttt agaaaaattt aatgaaaaaa ataatcttga
     4501 tgaaacaaga aatgctataa agcaattacg aattgaaaaa gaaaatattg aaaaaaaaat
     4561 agatgagaac atagatactt tacttgaata ttttatgcag caaaaaaaaa taaatcttgg
     4621 atcaagttat gaaataccag tacctataca aagtaatata attaaaaaaa ctataaacga
     4681 acttcaattt tggcataata caggggcaac tataacagct attaaaagag attatgagct
     4741 ctttatttca cctgggcctt attttgaatt tatagaagga gatataattt gttttatatg
     4801 tacagcagaa aattattata aagtagaaga tttcgtaaat aaaaaagctg aaatattaag
     4861 ctgatattta ataaaccggc aattaatgcc ggttttattt tttatttaat aatttcattt
     4921 aaaaactgga ggcaacttta ttataaattt cttcacataa tttttctgat tctgtataaa
     4981 ttgcctgacc tcttttctta aaatcttctg ccatatttaa atcttttata ctgggaatat
     5041 tgattaacac atttaaccat gcacctttta cacaggataa tagatttaat gcagcaactc
     5101 ccaaatcact tacggcactt ttatttgatt ttccaatcag cttatatgtt aattttaacc
     5161 cttccagtcc ctgctgcata gcttcaagag gaacctcagt agctcctatc gtagttttaa
     5221 ttatagcatt acttcttaat actttttctt tgattgtatc tttaggcatt ttataagcag
     5281 aggaaagcaa attaaatgcg tccttatctt tatcaatacc taaaattaaa tcttctaata
     5341 acttctcagc ctttatttta acatctaagc aaagtggttc aaattcttta tatttttctt
     5401 tccctattgt taaatttatc accataagag aaagtgcaat accttgtgcc cctgcaagtg
     5461 cactggcagc accgcctcca ggagctggct ctgatgaagc taataattca ttatactttc
     5521 ttatgttaag atctgctaat ttcatatttc attccatttc taccaacttt gtaacagctt
     5581 ttatctatac ataggctata gtttctattt ctactaatac atcctttggc agtcttgcta
     5641 cttccactgc tgatcttgaa ggcaatactc cttctttaaa atattttgca taaataccat
     5701 tcatagctgc aaaatcatcc atatttttaa taaatacggt agtttttaaa actttgtcca
     5761 gagaacttcc agcttcttct aaaattgctt ttacattttt aaaaacttgt tctgtctgtt
     5821 cttctattgt ttttcccacg atttcacctg aagatggatt aattggaatt tgacctgatg
     5881 taaatagtaa attaccaaat atatttccct gtgaatatgg accaattgct gccggagctt
     5941 cctttgttga aacaattttt ctcatatttt tatctccttt tcatttttta gatactaata
     6001 ttttatcaat attaacattt gataaacata aatattttta tttgcatctt ttattaaaat
     6061 ttcttcccat attttctttt aatatttttt ctgtcattat aatttcttct tccgtcatgg
     6121 cttttttagg caatataaag gcttgctgaa tatttacgta taataagaaa tatttttttg
     6181 tttcataacc tttataaaat aaatcccatt tatattcact gtttctattt tctttgccgc
     6241 ctttaatttg aatcttattt tcatcaatta tatattgcct tttaatatga aaagaaactt
     6301 tatctgttct taacactcta cgaatcataa gttcttgaat aataaatatc aaaataataa
     6361 agaaaatcat tatcacataa aaataaaaat accaatccgg catatctaat tttccggatg
     6421 ctcttcctat catcataaca agtgctaaaa caaatataaa aacataagca aagattgtcc
     6481 atctttttct gaaaaacaag gtaaaattgc tgagtgcttt ataatcttct ttctttattt
     6541 cgaaatcaag ttttatttta ttattttcta tcatttatag taatcccctt acctttttcc
     6601 tctattaatt ttattttttt agctctagcc atatgtttta tcttccactc cattttcatg
     6661 gcctcttcct tcgtatcaaa tgactcactg taaactagag taacaggtct tcgtcctctt
     6721 gtatattttg cacctttacc gtcattatga gcttttattc ttgactgtaa atcatttgtc
     6781 cagcctccat ataatgttcc gtctttacag cgtaataaat atacataatt taatttttga
     6841 gaagtttttt tcatcttaat atgttaaatc ctttatatcg tatagtttac ttcatcatct
     6901 atttttaaat ttttcaaacc acgtataatt ataagcagcc atatgttaat aattatccaa
     6961 aagattatac tcaatactgc aataatctca aaattaaaac taactgaaat agctaaaatg
     7021 atacataaaa tactatatag taccgtaaaa atacgaatat ttttaatata ttcattcgcc
     7081 gctatagtaa gctctaatct ttctaatatt ctaacagctc ctgataatat ataaaaaatc
     7141 attataaaat ctgaaattat tcctagttct attataatca aattgaaaat taatgctata
     7201 ccttcataag aaattaactt aataaagaat ataataaatt ctataataat gctcatatag
     7261 caaaaagcca cagcattttt taactctttt atattttcat atttatataa catttgtttt
     7321 attccattta atactattaa taaacctata aaattaggga gaagctgaat agaacctaaa
     7381 tttatatgaa acattgtcaa aaataatccc caaaagattt tactatatcc ctctcccatt
     7441 tatattgatc ctctttcttt taaatacttt attaatttta taaaatcaca ttcaagatta
     7501 tatgtatttc tttcaatatt ataaattctt aattcatatg tattaccaaa atcatcttca
     7561 taagcaatta ctggcttaat atcatacatt gtataatagg acatagtatc taatttatct
     7621 ttaaatcttg attttacatc gattgtatca aatttttcat actgtatatt atttacttta
     7681 tcaaacttat taccatctat cgttaattca attaattcat tggtctcttt aaataaagga
     7741 ctattaacag aaagtaattt caaatttttt tcaacaatat atttttcttc tgaaatatgt
     7801 gaaccttcac ttgaagtgct cccactataa tcatttgtca aaagctgtgt agaatttgtt
     7861 ttttttgaga ataaaagtct tccaagctgt acattcatac tagtgccgtc actaaacatt
     7921 acttctgcat tatttaattc taatatacta ttatcattaa atatatcttc tctagacagt
     7981 aaatttacat aaaccgttct gatactataa gttccacacc tttcacctat tacattattt
     8041 tcattattat tgtagctaaa cacaaatgat gaattaggtt tatcttctga agcccaaaag
     8101 tcaagctctg gagcttctaa aaatgtaacg tttgttactt tggctttatc atcaatattt
     8161 gttatatacc gaattataaa ctgagtatct tcataatgat tttcatcatt aacatcttcc
     8221 tgtacttcat attcacaata agtttttaaa aaaacaggct catctaatct aagacaaaaa
     8281 ataaagccca aacatataaa tgctgtgaat ataatgcaag taatacatat cttgaagatt
     8341 ttaaaattta actccataaa atatccttaa tcctatttta ataattattc cttatagaaa
     8401 ataatacaaa ttacttcttt aactttaaaa atattaatgc catttaatta taatatatat
     8461 atatatttaa ttgtcaatct ttttaattct cattatctta cctaaagcaa ttacaaatat
     8521 aaataaaaat atggtaaata gagcgcccat tttagctgaa ccttgcaatg atacatctga
     8581 ataagcttca cttgcaacaa agagtgcaac ggttaaacct aaaccaccta ttagtcctgt
     8641 taaaaaaaca tcctttgccc gcataccttc aggaagttta aattttaaca aaacagcatg
     8701 acaagtaaat aaggaaattc caatagtttt tcctataact aaagaagcaa atacaatcca
     8761 tgttaattta gaaatctgtg agagttcaac ccctgcattt gaaatcccaa agaatatcaa
     8821 gccataatca acaagtggag atatttgatg ttcaaatttg tttaaagttg tatgaattgg
     8881 tgcatcatta actccatgca tatcaattaa ttctgtagat actcctttct taggcaaaaa
     8941 aggaacaata aatactaaag acaatgctgg gtgcaagtgt gcagcataca taccaatcca
     9001 tacaattgtc cctgcaccaa agatatatgg tacataactc ttaactctct ttctatttaa
     9061 ggtccaagct attaacattc ccacaactat taacaataac cataagggtt tcaccggctc
     9121 agttggatct gaatagaaaa ctgcgataat aataaggcca atggcatcat cggcaactgc
     9181 taaaagtaat aagaagctta ctgccggatg ttttttgcca aaaacaattc ttgctaatag
     9241 ccacgcaaga gctatatctg tggctgtaca tataccccat ccattaatat attcatcact
     9301 gccaaaaaaa tagttcaaaa taaaaaatgt aaaaatagga ccaataactc caccggctgt
     9361 agccattaac ggagttacag cttttctaat aggatttaaa gccccacctc ttgataaact
     9421 gtttagaatt tcaactcctg ctattgcaaa gaaaaaaacc ataaaaatat catttattaa
     9481 aaaatgaaaa tcaatattaa aaaaaattgg tgtatgaata aaatgatgat acgattcaat
     9541 tgatacattt gtccatatca atgatattat cactcctaaa atcaacggga tagaatactc
     9601 tctgcatcgt tccaatacca taaatgtcct ccaacgtaat actattattt tattttctct
     9661 attttaataa ttagaatata ctatatcaaa aatttaattt agtttcaatt tataataatt
     9721 aaatttggaa aaaaatgaat gatatttaaa tattccttca tatatatagt ataataatta
     9781 gtttaaaaaa attttaaaaa agatttgttt aaatttgttc ttttttaaat tatgtgatat
     9841 tatttttatt ggagtgtaaa ttattaaata attttttata atttttttta ttttataatt
     9901 taactttaga ttaaccttag ttttatattt tccccatata ataaaaaaaa acagtatttt
     9961 gtgaaaaaaa aaacatatca caagaaagga gactcaaatt ttgtcaatat taaaaaaaca
    10021 tttacaggga attcatgttg accacagaaa aaatacaatg aaccatgcta ttgagactat
    10081 gcctacaccg gatatagttt atattagtat gtctcaacat attggcgctc cctgtgagcc
    10141 attagtctct gtgggagatc atgtaaaaat tgggcagcct atcggcaatt cggaggcttt
    10201 tatcagtgct cctgttcatt ccagtgtttc gggaaaagtt actaatattg aagaagtcat
    10261 gtcatcactt ggaacaatgg ataagaccat aattattaaa acagataaaa aacaagaact
    10321 atgggaagac attaaaatac caacagctga aacaaaagaa gaatttatta aggctattag
    10381 ggatagtggc ttggttggtt taggcggtgc tgcatttcca actcacgtaa aatataaccc
    10441 tagaaatttg gatgaagtag ataccttaat agtaaatggt gccgaatgtg agccatatat
    10501 tacttcagac tacagaacaa tgcttgaaca tactcaagat attgtaaatg gtattttact
    10561 aatcatgaag catttggagc ttaaacagtg ttatatagga attgaggaaa ataaacctga
    10621 ggctattgaa agattaaatt catttttgtc tacatttcct aatataaaag ttataacttt
    10681 agattcaaga tatcctcaag gagctgaacg tgtattaatt tatgaaacaa caggtaaagt
    10741 tttacctccg ggaaaacttc ctgctgatat aggagttatt gtatcaaata taacttccat
    10801 agccttttta gctaaatatt ttagaacagg tgtaccactt atttcaaaag tggttacggt
    10861 tgacggagat gctgtctcta ctccaaagaa tgtcagagtt cctattggga caaagattta
    10921 tgaagtaatt aatttttgtg gaggatataa aaaacctcct aaaaaaataa ttttcggcgg
    10981 accaatgatg ggtagagcaa tttacgacga tggtaaacca ataataaaaa ataacaatgc
    11041 aattttggct tttgacgaag atcaagcatt aattcctaat gaaactgctt gtattaactg
    11101 tgggcgttgt gtacaagctt gtccgttaaa tttaatgcct actgctattg ataaagcata
    11161 taaaagaaat gatattgatg ctttaaagaa ccttaatgtt gcaatttgca tggaatgtgg
    11221 atgctgttcc tatgtttgtc ctgcaaaaaa acaattaagt ttagtaaaca aactatcaaa
    11281 agcacttgtt aaggaggcgg gaaaataaaa tgaaaaacta taaatatgat aatcttattg
    11341 tagcatcttc gcctcatttg gttgatagta taactacttc aaaaataatg gcaatggtta
    11401 ttatcgcgtt gatgcctgcc tttgccgtat ctatttgggt attcggtgca agagcaatat
    11461 ttttaacagg aatatgtatc atcgcatgtg tggtttttga gtatttgttt aataaaataa
    11521 ctaaaaaacc ttctactatt ggtgatttta gtgctgtagt aacaggtatt ttagtagcat
    11581 ttaatgtccc tgtaaatttt ccatactgga tggctattat aggttgtttt gtggctatta
    11641 ttattgcaaa acaactgttt ggaggaattg gacaaaattt tgtaaatcct gctattacag
    11701 ctcgtgtagt tctatttctc gcattctcta cagaaatgac cagctggcct accccacaaa
    11761 gaattttctt agcgacagat gcagtaaccg gtgcaacacc tcttgcatta tttgctaaac
    11821 agaattttga tcaactacct tctaatacag aaatgttctt aggaacaatt ggtggctgta
    11881 taggagaaac cagtgcttta gcacttttaa taggcggatt atttttattg tttaaaaaaa
    11941 taatttcacc tacaattcct gttagttttc ttgggacaat ggttgttatt tctctaattg
    12001 caggtataga tcctatattc cagatttgtg caggtggagc aatgataggt gcatttttta
    12061 tggcaactga ttattccaca tctccactta ctacaaacgg taaaataata tttggtatag
    12121 ggtgcggtct tattaccatg gtaataagac tatttggaaa ctatcctgaa ggtgtatctt
    12181 tttcaatatt gtttatgaat ttaattgttc cacatattga taacctttca agaagaaaat
    12241 tatacggtgg aggtgttaaa aatgactaaa tttaaagatt attttgcacc aactcttgtt
    12301 ttaatgatta tttgcctatg cgttacaatt gctttggctg ttacttataa tataactaca
    12361 ccaataattg aagcaagcgc tgctgctgaa gccagtgctt caagagcaga agtacttcca
    12421 tcaggtaaag acggttttac cgcttttgat gttaattata ccgaaggaat tcaagatgta
    12481 tatgcagctg ataataacag tggttatgcg attacttctt ataacaaggg cttcggaggc
    12541 aaggtttata ctatggtggg aattgacaac aaaggcgaaa taacaggtat aaaagtactg
    12601 tcacattccg aaactccggg tcttggaaca aaagctatga cccctgaata tctatctcag
    12661 tacatctctg catcaaaaat aactttgaca aatgaacctg atgctacaaa tatagatacc
    12721 ataacaggag ctactatatc atctaaagca atctatggtg ctataaataa tgcacttgtt
    12781 caatacgatg aattgagagg tgttaaaaat gactaaatta gatcttataa aaaacggaat
    12841 tataaaagaa aaccctgttt tagttctatt acttggtgcg tgtcctactt tggctgtaac
    12901 tacatcagct attaacggac ttggaatggg tgtttccact atgacagttc ttatttgttc
    12961 aaatattgta atatcccttt taaaaagcgt tatttcacct aaagtaagaa taccttgtta
    13021 tatagtagta attgcgggtt ttgttacaat ggtaggtttc ttacttaatg catatgttcc
    13081 tgatatatac gattccttag gtttatttat tcctctgata gttgtaaatt gtataatttt
    13141 aggcagggca gaaatgtttg caagtaaaaa ctctgttctt aattctgccg cagatggtat
    13201 cggtatgggg cttgggttta ctctagcatt gtttttaatg ggtgcaattc gtgagttctt
    13261 aggagctggt acactgtttg gatttactat aacagcgaat attattaaac ctatgactat
    13321 ttttgcttta cctccgggag gattctttgt tttcggctgc ttggttgcat taataaactt
    13381 tatttctaaa ggtcgtgcaa ttaaaaaaac tgaaatggga tgcagcaact gtccttctgc
    13441 cgaagcatgc ggaaagtctg agaaaggaga gtgcaataac taatgaaaga aattttaatg
    13501 attatgttca gtgttatcct tgttgataac tttgtactaa caaaattttt aggaatttgt
    13561 ccgtttttag gagtttctaa aaaattagac tctgccgttg gtatgagcgg agctgttatc
    13621 tttgtaatgg ttctagcaac tattgttacc tatccaatat atatatatat attagaacca
    13681 agcggtttaa aatatttaca aactattgta tttattttgg taatagcttc attagttcaa
    13741 ttagtagaaa tatctttaaa aaaatatata cctgcgcttc atagatctct tggagtattt
    13801 cttcctctaa ttacaacgaa ctgtgcagta cttggtgtta ctatactgaa tatcgatgaa
    13861 aactatactt atatacaatc aattttcaat gcactaggtg ctggaattgg ttttctttta
    13921 gcaatggtaa tatttgctgg cgtaagacaa aaaatcgaat attgtaacgt tcctgcgact
    13981 tttaaaggaa ttccgtcaat tctaattgca gcatctatag tttctgtttc ttttatggga
    14041 ttcagtggtg tagttgatgg aatttttaaa taggaggtag gattatgcaa caatattttt
    14101 taccaatcat cattgttata ataataggct ttttagcagg tactatatta accttagcct
    14161 caaaatttat ggcagtaaaa gtaaacgaaa cagttgttaa agtgaaagaa atattgccag
    14221 gtgcaaattg cggtgcttgt ggctatgcag gttgtgaaga ctatgctgta gcactagcca
    14281 acgaccctac aataaaacca aatttgtgca ccccgggagg aagttcagtg gcccttgcta
    14341 tcagtaatgc tttaggcata gaatttgaag ctgttgccgg aaaaacagca gtagtaaaat
    14401 gttcgggaac ttatgcaaaa accaactatg taatggatta tagaggatta caatcctgtg
    14461 cagcaaataa aatgttttat cgtggcagag gagcttgtga ttattcttgt ataggatatg
    14521 gagactgtgt tgatgcttgt gaatatgatg ctataaaaat cgaaggcgga gtagccgttg
    14581 ttgacaatga taaatgtgta ggctgcggtc tttgtgcaaa gaggtgtcca aataacttga
    14641 ttgatatagt accgggcagt aatttcgttt atgtaggctg ctcttcaaat gaaaaaggtg
    14701 ctgttacaaa agataaatgt actataggtt gtataggctg taagaaatgt gaaaagattt
    14761 gtaaattcga tgctattcat gttataaata atcttgcagt tattgattac gataaatgta
    14821 aaaattgtaa aatgtgtatt aatgaatgcc ctgtgggtgt tattaaattt aataattaaa
    14881 tatttatatg aaaaaaatag actttcttat aaatgatgtg accccaataa gttagactct
    14941 atagcgaagt agtatttttt actgcttcgc catttttatg ctacttggct gagtcgatat
    15001 tcaacaggac tcatccaaga tagtttttgc ttgattcttt gattattata ataatatatg
    15061 tatttctcta ttgcatcctt caattcttca taactatagt aaacgcagcc ataatacatt
    15121 tcttgtttca tcactccaaa aaaattctcc attattgaat tatcgtagca atttcctttt
    15181 cgtgacatac tttgatatat acggtttgat ttaagattac tactgtatgc cttcatttgg
    15241 taagcccagc cttgatctga gtgaaaa
//
