LOCUS       c00050_NZ_CAUE..       13498 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CAUEFJ010000050.1 MAG: Catenibacterium mitsuokai isolate
            SRR17382081_bin.77_MetaWRAP_v1.3_MAG ERZ18707875.4055, whole genome
            shotgun sequence.
ACCESSION   c00050_NZ_CAUE..
VERSION     c00050_NZ_CAUE..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-03-13 23:56:19
            Original ID  :: NZ_CAUEFJ010000050.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13498
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13498
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1905:6132](+)"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1906..6132
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
     cand_cluster    1..13498
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /kind="single"
                     /product="Others_HGD_unassigned"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13498
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Others_HGD_unassigned"
                     /region_number="1"
                     /rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1,
                     HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and
                     minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF,
                     ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C,
                     Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and not (minimum(2,
                     [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /tool="gutsmash"
     CDS             2..163
                     /locus_tag="ctg50_1"
                     /transl_table=11
                     /translation="KQLSVTNKTVINRLAVLVKNGFVIPILVNKRIRSYKLSEFAINHE
                     REIKEAVG"
     CDS             196..912
                     /locus_tag="ctg50_2"
                     /transl_table=11
                     /translation="MDDQFIKSVVFDWDKVDNDSYVKKIEGFRGIDKLKFNKSITFFVG
                     ENGSGKSTLLEALAVAHGFNPEGGTKNYDFSTYDNHSELCDAIKIQKSHRKERWGYFLR
                     AESFYNVATQEEEYADEAHPSEKYHEQSHGESFLALAQKHLQPNSLYFFDEPEAALSPQ
                     RQLTLLMLIYRCAQAGSQFFIVTHSPILLGIPDADIYCFDCGSIHLCEYEETDSYAITE
                     MFINNREMLLDKLLKD"
     CDS             921..1676
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_9"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg50_3"
                     /sec_met_domain="Fer4_9 (E-value: 4.1e-11, bitscore: 32.9,
                     seeds: 61, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 4.3e-10, bitscore: 29.1,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_6 (E-value: 6.8e-09, bitscore: 25.6,
                     seeds: 134, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 5.2e-07, bitscore: 20.0,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKYRITFSPTGGTEKVSKSITKNWGHVEDIDLSVVDKNYQDISL
                     TENDIAVIAMPTYAGLAPQVALDRLAKINAHNCKCVIFAVYGNRSYEDTLVQMEDYAHM
                     AGFDVIGAISAIAEHSIFHQFATGRPDENDCHQLEEFGDQILEKASNKINTKPNIPGHR
                     PYKKIGGGTIPQANTLCTKCDLCVMKCPTGAISKDNPQVTDKNKCISCMRCVDVCPNQA
                     RKLDQEKMAVIETAITKVCSIKKECELFL"
     CDS             1906..6132
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: BcrAD_BadFG"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg50_4"
                     /sec_met_domain="HGD-D (E-value: 1.1e-52, bitscore: 169.6,
                     seeds: 370, tool: rule-based-clusters)"
                     /sec_met_domain="BcrAD_BadFG (E-value: 3.5e-41, bitscore:
                     131.3, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYYLGIDVGSTTVKLYLTDENDKCLFSKYTRHFSDVRKTIYELL
                     IEVKNQMGDIDLYPVMTGSGGLSLADKLGISFIQEVIACTKTVETYIPQTDVVIELGGE
                     DAKITYFEGQLEQRMNGTCAGGTGAFIDQMATLLKTDAAGLNEYAKNYKTIYPIASRCG
                     VFAKTDIQPLINEGVSKEDIAVSIFQAVVNQTISGLACGKPIRGNVAFLGGPLYFMDQL
                     RERFIETLGLTEDEIIFPQNSQLFVAMGACLNAKEKVESPLNISKIIEDLEGLSDSPTE
                     LTNVLEPLFNDEAELKEFRERHFTHITKKRTLKKYKGKVFLGIDVGSTTSKIIMTDEQG
                     AILYSFYSSNEGNPLQLIMSLMKEIYQMLPEGCYIAKAGVTGYGEALIKAALKVDIGEV
                     ETIAHYTAAKAYEPDVDFILDIGGQDMKAITIRDNVIQNISLNEACSAGCGSFLETFAK
                     SLGYKIEEFAELALKSKHPIDLGSRCTVFMNSKVKQAQKEGASVEDISAGLSYSVIKNA
                     LYKVIKLRSKEDIGKHVVVQGGTFYNEAVLRAFEKETGIEVVRPDIAGLMGAYGMARIA
                     IENDDNEPSTILSLEEIEALDYDTKIRNCGKCTNNCMLTITSFNDGREYISGNRCERGA
                     NLPMTSKKLPNLYDYKYGRIFGYKSLSKDDAKRGEVGIPRVLNMYENYPFWHTFFTQLG
                     FRVVLSARSSKKIYEKGIESIPSENACYPAKISHGHIENLIERGIPFIFYPSVAYERKE
                     YEDAGNHYNCPVVASYPEVIRNNVDSLEEHNVKYKNPFLSLNNPKTLFKVMKESLAEYD
                     ISDKEMHNAIDKAYQELARARKDIEVKGQEALEWMHKNHKKGIVLAGRPYHVDPEINHG
                     IASLITSEGFCVLTEDSVCNLNKENLDLRVVDQWTYHSRLYRAAEFVTTQPDLELIQLT
                     SFGCGLDAVTSDQVAELLQARGKIYTLIKIDEASNLGPIRIRIRSLKATVKKKDNTVHL
                     ENKYESEKVSFTEEMKDDRWTILCPQMSPIHFQFVETAMNSEGYNFVVLPSVDKDAVDQ
                     GLKYVNNDACYPSILVTGQMMNALNSGKYDPHKVALIISQTGGGCRATNYIAFIRKALK
                     DAHMDYVPVISANLQGLESNPGFKITYKVAKKVIIGAMYGDLFMRVLYRVRPYEKVKGS
                     ANELYESWVEKCKENVENGSMKEFKKNVYQIVKEFDELPLLDIKKPRVGLVGEILVKFH
                     PTANNEIVKIIEEEGAEAVMPDLIDFFQYCFYNTQYEYEHYDASWKSAKLCNVAIKLVD
                     FLRKDMIKALEASNRFDAPHPIDQIAKKASEVVSIGNQTGEGWFLTGEMIELIDEGAPN
                     IVCMQPFACLPNHVTGKGVIKALRRKYPQSNIVAIDYDPGASETNQLNRIKLMLSTAFK
                     NMESSK"
     CDS             6144..6464
                     /locus_tag="ctg50_5"
                     /transl_table=11
                     /translation="MEDGHSTPPSRGRAILGFIRSKLNYNKISVLKKLACKNNPVIYRR
                     VLQELGDYKYKKKPVKGITLSQADYDTCCLILTVMVEKDFDYYYDQGDVKRTIERMIDL
                     LS"
     CDS             6474..6998
                     /locus_tag="ctg50_6"
                     /transl_table=11
                     /translation="VRKIKEVVVVEGKTDTATLKQLFDVDTIETSGSGINEDILSLIKT
                     AAQTRGVIVLTDPDYPGTQIRNKVIQAVPNAKHAFVAKKDAKGVKKLGIAEARHDAIIE
                     ALENAVTFSDAKESISWDEFIDLDVLGNKKRRLQVYDAFHLGYGNAKALFKRLNMMGIT
                     KEEVLKALKSQ"
     CDS             complement(7021..7398)
                     /locus_tag="ctg50_7"
                     /transl_table=11
                     /translation="MNNTEQYIHNIWTIMPMHTNKEKFYLLDLKKHLKEFMDDHPDCSY
                     EDIVEHFGEPKDIVVEYIQNSDENYLIQRMRLKEVFQKFIVFLCILCTLLAIWFGLLWY
                     DVYRNSKYSGVGEIKYTITDQ"
     CDS             complement(7391..7729)
                     /locus_tag="ctg50_8"
                     /transl_table=11
                     /translation="MAKKNQFFKLDMLLLCIIAKQDCYGYEITKQIKTYSHELIDIKEG
                     TMYPILYKLQDAHYISSYEKVIERKIRVYYHIEEEGKEKLLEMINEFNQAVDGIHNVIK
                     ESLGESYE"
     CDS             complement(7985..8086)
                     /locus_tag="ctg50_9"
                     /transl_table=11
                     /translation="MTNNVFPMNGKTKLEQNIVGSEEILIGILPRLK"
     CDS             complement(8153..8650)
                     /locus_tag="ctg50_10"
                     /transl_table=11
                     /translation="MDRKTRIMEIISSSDKPVSASKIAKELGVSRQIIVGDVALLRASG
                     EDITATPRGYILDTNRSNHYTIAVKHNNDQLEEELNTIVDLGGKVEDVIVEHPLYGEIK
                     GNLHIYSRYDVSKFMSAVKDNDIAPLSLLTDGVHLHTITVPDEETLERIKEALDEKHIL
                     LK"
     CDS             8735..9553
                     /locus_tag="ctg50_11"
                     /transl_table=11
                     /translation="MENIAKKSNTEFILNTFNLKPSKKYGQNFLVDPGIIQSIADHASL
                     DKETAVIEIGPGIGALTEQLSNKAGKVLCFEIDERLKEVLSFSLEGHDNVEIIFQDFMK
                     ADLEEACNKLKDYKDICVVTNLPYYITSKIITKIVSSSTPINRLVAMVQKEVALKLCSE
                     EKSPLKMMIDYVGDVQYELNVPRHVFMPAPHVDSAVISIHKERVISQELIDLIEASYTA
                     KRKTLYNNLKSLYHDQTKELLESCGIPANKRAEELNIDDYIRILERSHTL"
     CDS             9550..10416
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GHMP_kinases_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GHMP_kinases_N"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg50_12"
                     /sec_met_domain="GHMP_kinases_C (E-value: 5.3e-09,
                     bitscore: 26.4, seeds: 112, tool: rule-based-clusters)"
                     /sec_met_domain="GHMP_kinases_N (E-value: 1.7e-11,
                     bitscore: 34.2, seeds: 447, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIRAYAKINLALDVVSEREDGYHELNMIMAPIVLHDLILIDPIE
                     KGIEITTNTYRVPTDERNIMYKVADALIKKFDIQSGVRIHCYKHIPSQAGMGGGSADGA
                     AIFRAMNSLFHLRMSYQDMCEMGKEIGADIPFCVWNRIAVVGGIGENLHFIDRSRFNCH
                     LLIVKPKKGVSTKKCFDDLDIETAVHPDIDLMKHAIEKNDYQGVVDCLGNTLEAPSIKM
                     VQDIQSIKDDMMNFGFDGALMSGSGSSVFGMTQDPELIDKVLPYFKKKYSFAIKTQIYY
                     PEKRKKG"
     CDS             10487..11884
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Hexapep"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IspD"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg50_13"
                     /sec_met_domain="Hexapep (E-value: 4.8e-11, bitscore: 32.1,
                     seeds: 216, tool: rule-based-clusters)"
                     /sec_met_domain="IspD (E-value: 3.1e-14, bitscore: 43.1,
                     seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVYAVVLAAGKGTRMKSDAPKVVHEVLYKPMINHVVDELKKLDI
                     AETVVVVGHGADQVKALLDNDVTTVLQEEQKGSGHAVMMAESVLGDKEGITLVLNGDAP
                     LITAETLQGLIDYHMNGKNSGTVMTCDCDLSLPFGRIIKEDGQVTGIVEFKDLQESQMD
                     ITEMNVGEYCFDNKSMFEALKKVTNNNAQGEYYITDLIGIMNEEGKKVDGYKIQDFSEV
                     GGINDRVQLAEATKLLQKRVNKNWLLNGVTIVDTDNTYIGTDVVIGKDTIIEPGCIIKG
                     HTTIGAHCHIGPYCEFTDVDIKDNVEIKFSVLSDSVVESGTDIGPYARLRTNCHIRENV
                     HIGNFVEMKKADFGKGSKSAHLTYIGDAKVGDGVNIGCGTITSNYDGKNKSMTVIGNNA
                     FIGCNSNLVAPVTVGEGAFVAAGSTVTETVEDGAMSIARARQVNKPGYAKVLEEKRMKI
                     YNERNKK"
     CDS             11900..12850
                     /locus_tag="ctg50_14"
                     /transl_table=11
                     /translation="MKNKITVFSLSSSKKLAQDIASILGTKVGDCKVHHFADGEILCEI
                     GESVRGKDVFIVQSTSNPVTENLMEILVLTDALKRASAREITAVIPYFGYARQDRKAKP
                     RQPITSKLVADLLTTAGVNRVVTVDLHAAQIQGFFDIPVDEMQALPLLIKYFRKKKVQD
                     LCVVSPDHGGATRARKMSEAFDCPIAIIDKRRPKPNVAEVMGIIGNVEGKNCILIDDMI
                     DTAGTITAGVDMLKQKGAKDVYIACTHGVLSGPAVERLSTCAAKEVVITNTIEIPQDKK
                     FDKLVSVSVAGLLAHTIENIENDLPVSDVFTQYDC"
ORIGIN
        1 taaacaatta tcagtcacaa ataagacagt tattaataga ttggcagtat tagtgaagaa
       61 cggatttgtg attccaatat tagttaataa gagaatccgt tcctataaac taagtgaatt
      121 tgcgataaat cacgaaaggg aaattaagga agcagttggg taatataatt tatttaaatt
      181 tgctgaggtg atgatatgga tgatcaattt ataaaaagcg ttgtatttga ttgggacaaa
      241 gtagataatg atagttatgt aaaaaagata gagggattta gaggtattga taagcttaaa
      301 ttcaataaat ctattacttt ctttgtaggt gaaaatggca gtggtaaatc tactttacta
      361 gaggcgcttg ctgtagcaca tggttttaac cctgaaggag gtacaaagaa ctatgatttt
      421 tctacctatg ataaccattc agaattatgt gatgcaataa aaattcaaaa aagtcaccga
      481 aaagaaagat ggggatattt ccttagggct gagagctttt ataatgtagc aacacaggag
      541 gaagaatatg ctgatgaagc acatccatct gaaaaatatc atgaacaatc acatggagaa
      601 agttttctag cattagccca gaaacattta cagcccaata gcttatactt tttcgatgaa
      661 ccagaagctg cattatcacc acaaagacag ctcacattat taatgttgat atacagatgt
      721 gcacaagctg ggtcacagtt tttcatagtc actcattctc ctattttatt aggtatacca
      781 gatgcagata tatattgttt tgattgtgga agcatacatc tatgtgagta tgaggagaca
      841 gatagttatg caataacaga gatgttcatt aataatagag aaatgttgct tgataaatta
      901 ttaaaggatt agaggatata atgaataagt acagaattac attcagtcca acaggtggaa
      961 ctgaaaaagt atcaaaatca atcacaaaga attggggaca tgtagaagac atagatcttt
     1021 cagttgtaga taagaattat caagatatat cattgacaga aaatgatatt gcggtgattg
     1081 ccatgccaac ttacgcagga ttagcaccac aagtcgcatt agatagactt gctaaaatca
     1141 atgcacataa ttgtaaatgc gtcatttttg cggtatatgg aaatagatcg tatgaagata
     1201 cacttgttca aatggaagat tatgcacata tggctggatt tgatgtcatt ggggctatat
     1261 cagccattgc tgaacattct attttccatc aatttgcgac aggaagaccg gatgagaatg
     1321 attgtcatca attagaagaa tttggtgatc agattctaga aaaagcatct aataagatta
     1381 atactaaacc gaatattcca ggtcatagac cttataagaa gataggtgga ggaacgattc
     1441 ctcaagcaaa taccttatgt acaaagtgtg acttatgcgt aatgaaatgc ccaacaggtg
     1501 ctattagtaa agataatcca caagtgacag acaagaataa atgtatttca tgtatgcgtt
     1561 gtgtggatgt ttgtccaaat caggcaagaa agctagatca agagaagatg gcagtcatag
     1621 aaacagcaat tacaaaggtt tgttcaatca aaaaagagtg tgaattattt ctataattta
     1681 atagaaggaa atcaagaaga ggacgagatt agatgatatt ttcatccttc cttcctcttt
     1741 ttgactttgt tagacaagcg ttgtactttt ccttacaaat agttaaattt tgtgtattta
     1801 tcgttatatt ttataatttt attaggcaaa aaactagatt atttcttaaa attcgtttaa
     1861 tataggttcg atataataca caaaaaaaga gaaggatgtg gaaatatgaa atattattta
     1921 ggaattgatg taggatctac gactgtaaaa ctctatttaa cagatgagaa tgataaatgc
     1981 ttattttcta agtacacaag acatttctca gatgttagaa aaacaatcta tgagttatta
     2041 attgaagtaa agaaccagat gggtgatatt gatttatatc ctgttatgac tggttcagga
     2101 ggtttatctc ttgcagataa gcttggtatt tcttttatac aggaagttat tgcgtgtaca
     2161 aagacagtag aaacatatat tccacaaact gatgttgtta tagagcttgg tggagaagat
     2221 gccaagatca cttattttga aggacagctt gaacagcgta tgaacggtac ttgtgcagga
     2281 ggtactgggg catttattga ccagatggca actttattaa agactgatgc tgcaggttta
     2341 aatgaatatg cgaaaaacta taagacaatc tatcctatcg catcacgttg tggtgtcttt
     2401 gcgaaaacag atattcagcc tttaattaat gaaggtgtat ctaaagaaga tattgcggta
     2461 tctattttcc aggcagtcgt caatcagact atttctggtc ttgcctgtgg taaacctatt
     2521 agagggaatg ttgcattctt aggtggtcca ctttatttca tggatcagtt aagagaacgt
     2581 tttattgaaa cattaggttt aactgaagat gaaatcatct tcccacagaa ctcacagcta
     2641 tttgttgcta tgggggcatg tttaaatgcg aaagaaaagg tagaaagccc attaaacatc
     2701 tctaagatta ttgaagattt agaaggtctt tcagactccc ctacagaact tacaaatgtc
     2761 ttagaaccat tatttaatga tgaagcagaa ttaaaagaat tcagagaaag acactttacc
     2821 catatcacta agaaaagaac acttaagaaa tataaaggta aagtattctt aggtatcgat
     2881 gttggttcta caacatctaa gatcatcatg actgatgaac agggtgctat tttatattct
     2941 ttctatagtt ctaatgaagg aaatccatta cagttgatca tgagtctgat gaaggaaatc
     3001 tatcagatgc ttccagaagg atgttatatt gcgaaagccg gtgttactgg ttatggtgaa
     3061 gcccttatta aagctgcttt aaaggtggat attggtgaag tagaaacaat tgcccattat
     3121 actgccgcaa aagcctatga acctgatgtg gatttcattc tagatattgg tggtcaggat
     3181 atgaaggcta ttactattag agataacgtc attcagaaca tttcattaaa tgaagcatgt
     3241 tctgcgggat gtggttcatt cttagagaca ttcgcaaaat cattaggtta taagattgaa
     3301 gaattcgcag aacttgcatt aaagtctaaa caccctattg atttaggttc tagatgtaca
     3361 gtattcatga actcaaaggt aaaacaggca caaaaagaag gtgcttcagt agaagatatt
     3421 agtgctggtt tatcttattc agttatcaag aatgcgttat ataaagttat taaactaaga
     3481 agtaaagaag atattggtaa gcatgttgtt gtacagggag gtactttcta taacgaagct
     3541 gtactacgtg catttgaaaa agaaacaggt attgaagtag taagacctga tatcgcaggg
     3601 ttaatgggtg cttatggtat ggctcgcatt gcgattgaaa atgatgacaa tgaaccttct
     3661 actattcttt cattagaaga aatagaagca cttgactatg atacaaagat cagaaactgt
     3721 ggtaaatgta caaacaactg tatgttgact attacatcat ttaatgatgg tagagaatat
     3781 atttcaggta atagatgtga aagaggagcg aatcttccaa tgacatctaa gaagttacct
     3841 aacctctatg attataaata tggtcgtatc tttggttata aatcactttc taaagatgat
     3901 gcaaaaagag gagaagtggg tattcctaga gtacttaata tgtatgagaa ctatccattc
     3961 tggcatacat tctttactca gttaggcttt agagttgtct tatcagcaag atcttctaag
     4021 aagatttatg aaaagggtat tgaatctatt ccatcagaaa atgcctgtta tccagcaaag
     4081 atttctcatg gacatattga aaacctgatt gaaagaggta ttccttttat cttctatcca
     4141 tcagtagcat atgaaagaaa agaatatgaa gatgcgggta atcactataa ctgtccagtt
     4201 gttgcttctt atccagaagt tattagaaat aatgtagaca gcttagaaga acacaacgtg
     4261 aaatataaga atccattctt atctttaaat aaccctaaga cattatttaa ggtaatgaag
     4321 gaatctttag ctgaatatga tatttcagat aaggaaatgc ataatgcgat tgataaggct
     4381 tatcaggaat tagcacgtgc aagaaaagat attgaagtta agggtcagga agcattggaa
     4441 tggatgcata aaaaccataa gaagggtatt gtccttgcag gacgtcctta tcatgtggat
     4501 ccagaaatca accatggtat tgctagctta attacaagtg aaggtttctg tgtattaaca
     4561 gaagattctg tatgtaattt aaataaagaa aacttagact tacgtgtagt agaccaatgg
     4621 acatatcatt ctagactcta tcgtgctgct gaattcgtaa caactcagcc agatcttgaa
     4681 cttatccagt taacatcatt tggatgtgga ttagatgcgg ttacaagtga ccaggtggct
     4741 gaattattac aggcaagagg taagatttat acacttatta agattgatga agcctctaac
     4801 ttaggaccaa tcagaatccg tattagatca cttaaagcaa cagtaaagaa gaaagacaat
     4861 actgtacact tagaaaataa atatgaatct gaaaaggtat cattcacaga agaaatgaag
     4921 gatgatagat ggactatttt atgtcctcag atgtctccta ttcatttcca gtttgtagaa
     4981 actgcaatga attcagaagg ttataatttt gtggtattac cttctgtaga taaagatgct
     5041 gtagaccagg gattaaagta tgttaacaat gatgcatgtt acccaagtat tttagtaaca
     5101 ggtcagatga tgaatgcctt gaattcaggt aagtatgatc ctcataaggt ggcattgatc
     5161 atctcacaga caggtggagg atgccgtgca actaactata ttgcgtttat tagaaaagca
     5221 ttaaaggatg cacatatgga ttatgtacct gttatttcag caaacttaca gggattagaa
     5281 tctaacccag gctttaagat tacttataag gtggctaaga aggttattat tggggctatg
     5341 tatggtgact tattcatgag agttttatat cgtgtcagac cttatgaaaa ggttaaaggt
     5401 tcagctaatg aattatatga atcatgggta gaaaagtgta aagaaaacgt tgaaaatggt
     5461 tctatgaagg aattcaagaa gaacgtttat cagattgtaa aggaatttga tgaattacca
     5521 cttctagata ttaagaaacc tagagtaggt cttgtaggag aaatccttgt gaagttccac
     5581 cctactgcca ataatgagat tgtaaagatt attgaagaag aaggcgcaga agcagttatg
     5641 ccagatttaa ttgacttctt ccagtattgt ttctacaata ctcagtatga atatgaacat
     5701 tatgatgcaa gctggaaatc agctaagtta tgtaatgtag caattaaact cgtagacttc
     5761 ttaagaaaag atatgattaa ggcattagaa gcatcaaatc gttttgatgc accacatcct
     5821 attgatcaaa ttgcgaagaa agcaagtgaa gttgtttcta ttggtaacca gacaggtgaa
     5881 ggatggttct taactggtga aatgattgaa ctcattgatg aaggtgcacc aaatatcgta
     5941 tgtatgcagc catttgcctg cttacctaac catgtaacag gtaagggtgt cattaaggca
     6001 ttaagaagaa aatatccaca gtctaacatt gttgcgattg attacgatcc aggggctagt
     6061 gaaacaaacc agcttaaccg tattaaattg atgttatcaa cagcatttaa gaacatggaa
     6121 tcatctaaat agtggaggaa gatatggaag atggacattc caccccgccc tcgcgaggta
     6181 gggctattct aggctttata agatcaaaac tgaattataa taagatttct gtattaaaga
     6241 aattagcctg taagaataac cctgtaatat atagacgtgt attacaagaa ttaggcgact
     6301 acaagtataa aaagaaacct gtgaagggta taaccctttc acaggctgat tatgatacat
     6361 gctgccttat actcactgta atggttgaga aagatttcga ttattattat gatcagggag
     6421 atgtcaaacg tacaatagaa cgtatgattg acttactgag ttaggagatt attgtgagaa
     6481 agattaaaga agttgttgta gtagaaggta aaacagatac agcaacactt aaacagttat
     6541 ttgatgtaga tacaattgaa acatctgggt caggaatcaa cgaagatatt ctatctctca
     6601 ttaaaactgc tgcccaaaca cgtggcgtca ttgtcttaac agaccctgat tatcctggta
     6661 cacagattag aaataaagtc attcaggctg ttcctaatgc gaagcatgct tttgtcgcaa
     6721 aaaaggatgc taagggtgtg aagaagcttg gtattgcgga agcaagacat gatgcaataa
     6781 ttgaagcatt agagaatgca gtcacattta gtgatgctaa agaatccatt tcatgggatg
     6841 aatttattga tctagatgta ttaggaaata agaagagaag actacaggtc tatgatgcct
     6901 ttcatttagg ttatggtaat gcgaaagcat tatttaagag actgaatatg atgggtatta
     6961 caaaagaaga agtacttaaa gcactaaaga gtcagtagac atagtatcta ctgactcttt
     7021 ttattgatct gttatggtat attttatttc tcctacacct gaatattttg aatttctata
     7081 gacatcatac caaagaagac caaaccatat cgcaagtaat gtacaaagga tacaaagaaa
     7141 aacaatgaac ttctggaaca cttcttttag tctcattctt tgaatcaaat agttttcatc
     7201 actattctgg atatattcaa cgactatatc ctttggttca ccaaaatgtt ctacaatatc
     7261 ttcatatgaa caatcaggat gatcatccat gaattctttt aaatgtttct ttaaatcaag
     7321 aagatagaat ttctctttat ttgtatgcat gggcataata gtccaaatat tgtgaatata
     7381 ttgttctgta ttattcataa gattctccta aagattcctt aatcacatta tggattccat
     7441 ccacggcttg attaaattca ttaatcattt ctaatagctt ttctttaccc tcttcttcta
     7501 tatgataata gactcttatt ttgcgttcta ttaccttctc ataactagaa atatagtgtg
     7561 catcctgtaa tttatagaga ataggataca tagtgccttc tttaatatct atgagttcat
     7621 gagagtaagt tttaatctgt ttcgttattt catacccata acaatcctgc ttcgcaataa
     7681 tacatagaag aagcatatcc agtttgaaaa attgattctt tttggccata ttaatcgatc
     7741 ctcaacattc atatacttat attatacttt gtgttttaaa agtagcaata catagatatg
     7801 ctatgtacaa agagcaacat tcatgatatt atatgtatgt ggaaacgttt tcgataaaat
     7861 catttttata ttaatcggag ggattattta tgcttagctc taaagagaag aagttcatta
     7921 tctgttttgt gatttatgtg gcattattca ttgcgtcagc tttctattgt gatcaaaccg
     7981 ttctttattt cagtctagga agtattccta ttagtatttc ttcactacct acaatattct
     8041 gttctaattt agttttacca ttcattggaa atacattatt agtcatctat ttctttaaag
     8101 atgacatcaa aaacttcttc aagatataat aaaaaggctg ttcaccacag ccttatttta
     8161 ataatatatg cttttcatcc aatgcttctt taatacgctc taatgtctct tcatcaggta
     8221 ctgtaattgt atgtaagtga acaccatccg ttaatagaga aagaggtgca atgtcattat
     8281 ctttaactgc agacatgaac ttagatacat cataacgtga atatatatgt agatttcctt
     8341 tgatttctcc ataaagagga tgttctacta tcacatcttc taccttacca cctaaatcta
     8401 caatggtatt taattcttct tctaattgat cattattatg ctttacggca attgtataat
     8461 gattacttct atttgtatct aatatatatc ctctaggtgt tgcagtaata tcttctcccg
     8521 atgctcttag taatgcaaca tctcctacaa taatctgtct agaaacacct aattctttcg
     8581 caattttact tgctgaaaca ggtttatcac tactacttat tatttccatt attcttgttt
     8641 ttctatccat atatatcacc ttttcgacca ttatagaaga atttttcagg gaactcaatg
     8701 gtcttttctt tacatatcct atataataaa tgatatggaa aatatcgcaa aaaaatcaaa
     8761 tacagaattt atattaaata catttaactt aaagccttct aagaaatatg gacagaactt
     8821 cttagtagat ccaggtatta ttcaaagtat cgcagatcat gcttcgctgg ataaggagac
     8881 agcagttatt gaaataggac ctggtatagg cgctcttaca gaacagctct ctaataaagc
     8941 tggtaaagta ttatgctttg aaatagatga acgtttaaag gaagtattat cattctcttt
     9001 agaaggacat gataatgtag aaatcatctt ccaggacttt atgaaagctg atttagaaga
     9061 agcatgtaat aaactaaagg actataagga tatctgtgtt gtcacaaatc ttccttatta
     9121 tattacgtct aaaatcatca caaagattgt atcttcttct acacctatta atcgtttagt
     9181 cgctatggta caaaaggaag tcgcactaaa gctctgttct gaagaaaaga gtcctttaaa
     9241 gatgatgatt gattatgtag gagatgttca atatgaattg aatgttccta gacatgtatt
     9301 tatgccagca cctcatgtag atagtgctgt tatttctatt cataaagaac gtgttatatc
     9361 acaggaattg attgatctga ttgaggcaag ttatactgca aaaagaaaaa cactctataa
     9421 taacttaaag tctttatatc atgatcaaac aaaagaatta ttagaatcat gtggtattcc
     9481 tgccaataaa cgtgctgagg aattaaacat tgatgactat ataagaatac tagaaaggag
     9541 tcatactcta tgaagattcg tgcttatgcg aaaataaacc ttgcattaga tgtagtaagt
     9601 gaaagagaag atggatatca tgaattaaat atgattatgg cccctattgt tcttcatgat
     9661 ttgattctta tcgatcctat tgaaaaaggt atagaaatta ctacaaacac ataccgcgta
     9721 cctactgatg aacgtaacat tatgtataag gttgcggatg cattaatcaa gaagtttgat
     9781 atccaaagtg gtgtaagaat ccactgttat aagcatattc catcacaagc tggaatgggt
     9841 ggaggaagtg ccgatggtgc tgccatcttc cgcgcaatga acagcttatt ccatttacgt
     9901 atgtcttatc aggatatgtg tgaaatgggt aaagagattg gtgcagatat tccattttgt
     9961 gtatggaatc gtattgcggt tgtaggtggt attggtgaaa atctacattt tattgatcgt
    10021 tcacgtttta attgtcattt attgattgta aaacctaaga agggtgtttc tacaaagaaa
    10081 tgttttgatg atctagatat tgaaacagct gttcatccag atattgattt gatgaaacat
    10141 gcaattgaaa agaatgatta tcagggtgtt gtagattgtt taggtaatac tttagaagcg
    10201 ccttctatta agatggtaca ggatatccag tctattaagg atgatatgat gaactttggt
    10261 tttgatggtg ctcttatgtc aggtagtggt tcatctgttt ttggtatgac tcaagatcct
    10321 gaattaattg ataaagtgct tccatatttt aaaaagaaat atagttttgc aataaaaaca
    10381 cagatttact atccagagaa aaggaaaaag ggataactta cgccttttct cttttatttt
    10441 gaattgaatt ttgctagaat gtaggggaaa aaaaggagat atgtcgatga aagtttatgc
    10501 agttgtctta gctgcgggta aaggtacccg tatgaagtca gatgcaccta aggttgttca
    10561 tgaagtttta tataaaccaa tgatcaatca tgtggtggat gaattaaaga agttagatat
    10621 cgcagaaaca gtcgttgttg ttggacatgg ggctgaccag gtcaaggctt tgttagataa
    10681 cgacgtcact actgtcttac aggaagagca gaaaggctct ggacatgctg tcatgatggc
    10741 agaaagtgtt ctaggggata aagaaggaat cactcttgta ttaaatggtg atgcaccttt
    10801 aattactgcg gaaacattac agggacttat tgattatcat atgaatggta agaatagtgg
    10861 tactgtaatg acatgtgatt gtgacttgtc acttccattt ggtcgtatta ttaaggaaga
    10921 tggccaggta acaggaattg tagaattcaa agacttacag gaatctcaga tggatatcac
    10981 tgagatgaac gtaggtgaat attgttttga taacaaatca atgtttgaag ctttaaagaa
    11041 agtaacaaac aacaatgctc agggtgagta ttatattaca gatttaattg gaatcatgaa
    11101 tgaagaaggc aagaaggttg atggctataa gattcaggat ttcagtgaag taggtggcat
    11161 taatgaccgt gttcagcttg ctgaagcaac taagttactt cagaagagag taaataagaa
    11221 ctggttatta aatggcgtga ctattgtaga tactgataac acatatattg gtactgatgt
    11281 tgtaattggt aaggatacaa tcattgaacc aggttgtatt atcaagggac atactactat
    11341 aggggcacac tgtcatattg gtccttattg tgaatttaca gatgtagata ttaaggataa
    11401 tgtggaaatc aagttctcag tattaagcga ttctgttgta gaaagcggta ctgatattgg
    11461 tccttatgca agactaagaa ctaattgtca tattagagag aatgtacaca ttggtaactt
    11521 tgtggaaatg aagaaagctg attttggtaa gggaagcaag tctgctcatc ttacttatat
    11581 cggtgatgct aaagtaggcg atggcgttaa tattggttgt ggtactatca caagcaatta
    11641 tgacggtaag aataagtcaa tgactgttat tggaaacaat gcatttattg gatgtaattc
    11701 aaatctcgtt gcaccagtga ctgttggtga aggcgcattt gttgcagctg gatctactgt
    11761 aacagaaact gtagaagatg gcgcaatgtc tatcgcacgt gctagacagg tgaacaaacc
    11821 tggttatgca aaagttttag aagaaaaacg tatgaagatt tataacgaaa gaaacaagaa
    11881 ataaaaaaag gggacacata tgaaaaacaa aattacagta ttttctttat cttcaagcaa
    11941 gaaattagct caggatatcg caagcatttt aggtactaag gttggagact gcaaagttca
    12001 tcatttcgca gatggtgaaa tcttatgtga aatcggtgaa tctgttcgtg gtaaggacgt
    12061 attcattgtt cagtctactt ctaatccagt aactgaaaac ttaatggaaa tcttagtatt
    12121 aactgatgct ttaaaacgtg cttctgctcg tgaaattact gctgttattc catatttcgg
    12181 atatgctaga caggatcgta aagctaaacc tagacagcca atcacttcta agttagttgc
    12241 agacttatta actacagctg gtgttaaccg tgttgtaact gttgacttac atgcagctca
    12301 gatccaggga ttctttgata ttccagttga tgaaatgcag gctttaccac tattaattaa
    12361 atacttccgt aaaaagaagg ttcaggattt atgtgttgta tctcctgacc acggaggagc
    12421 tactagagct cgtaagatgt ctgaagcatt tgactgccct atcgctatca tcgataagag
    12481 aagacctaaa ccaaacgttg ctgaagttat gggtattatc ggtaatgttg aaggtaagaa
    12541 ctgtatctta attgacgata tgatcgatac agctggtact attacagctg gtgttgatat
    12601 gttaaaacag aaaggtgcta aagatgtata tattgcatgt actcatggtg tactttctgg
    12661 acctgctgtt gaaagattat ctacttgtgc ggcaaaagaa gttgttatta ctaacactat
    12721 cgaaattcca caggataaga aatttgataa acttgtttct gtatctgttg caggattact
    12781 tgcacataca attgaaaata tcgaaaacga tttaccagtt agtgacgtat tcactcagta
    12841 tgattgttaa tgtagaggac tcattacgag tcctttttta gaccaaatat atgaagtgaa
    12901 ataagtaaac tgctcctgtg gtttctatgt agtaactact tgactatgaa gtggttaagt
    12961 gttagacttc aaatgaattc agaaatcaaa atacatcaaa cgaaaaggta aggattggca
    13021 tatcattatc ttttctaatt tttagagtgg tttagcacta ggctagttat cgtttgaaaa
    13081 attcgtctaa ccatttgcag atgtagtagg taagaacacc agccatgacg gttatgaaaa
    13141 agtcgaacat caaactataa gcatatgaaa atgaagtgaa ataattactt atattatttt
    13201 tatgctacta tgacttatat cgtttttatg ctacgacgac ttgactatga agtggttaag
    13261 tgttaaactt caattgaatt caaaaaacaa aaagtatcaa acgaaaaggt aaggattgtg
    13321 ggatccttac cttttctaac ttttatagtg gtttaacact aggctagtta tcgtttgaaa
    13381 aattcgtcta accatttgca gatgtaataa gttagaacac ctgccatgac ggttatgata
    13441 aactcaaaaa acaaaaagca tcaccccctt tcaaggagga cgataacaaa gatattat
//
