GCF_000364225.2_ASM36422v2_genomic - 6 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_AQFT02000001 (original name was: NZ_AQFT02000001.1)

Region	Type	From	To
Region 1.1	cyclic-lactone-autoinducer,RRE-containing	937,057	978,592
Region 1.2	cyclic-lactone-autoinducer	1,833,542	1,865,647
Region 1.3	RRE-containing	3,290,027	3,309,566
Region 1.4	cyclic-lactone-autoinducer	3,372,829	3,393,319
Region 1.5	ranthipeptide	5,586,920	5,608,575
Region 1.6	lanthipeptide-class-ii	5,708,480	5,731,509

Region	Type	From	To	Similarity
Region 1.1	cyclic-lactone-autoinducer,RRE-containing	937,057	978,592
Region 1.2	cyclic-lactone-autoinducer	1,833,542	1,865,647
Region 1.3	RRE-containing	3,290,027	3,309,566
Region 1.4	cyclic-lactone-autoinducer	3,372,829	3,393,319
Region 1.5	ranthipeptide	5,586,920	5,608,575
Region 1.6	lanthipeptide-class-ii	5,708,480	5,731,509

No secondary metabolite regions were found in these records:: NZ_AQFT02000002 (original name was: NZ_AQFT02000002.1); NZ_AQFT02000003 (original name was: NZ_AQFT02000003.1); NZ_AQFT02000004 (original name was: NZ_AQFT02000004.1); NZ_AQFT02000005 (original name was: NZ_AQFT02000005.1); NZ_AQFT02000006 (original name was: NZ_AQFT02000006.1)

Compact view

c00001_NZ_AQFT.. - Region 1 - RRE-containing,cyclic-lactone-autoinducer

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Location: 937,057 - 978,592 nt. (total: 41,536 nt) Show pHMM detection rules used

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)
RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000504.1	0.57	RiPP	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000600.1	0.52	RiPP	thurincin H	Bacillus thuringiensis
BGC0000572.1	0.49	RiPP	capistruin	Burkholderia thailandensis E444
BGC0001407.1	0.48	RiPP	bicereucin	Bacillus cereus SJ1
BGC0001549.1	0.48	RiPP	citrulassin B	Streptomyces aurantiacus JA 4570
BGC0001551.1	0.47	RiPP	citrulassin E	Streptomyces glaucescens
BGC0001291.1	0.46	RiPP	enterocin NKR-5-3B	Enterococcus faecium
BGC0000569.1	0.46	RiPP	plantazolicin	Bacillus velezensis FZB42
BGC0000566.1	0.45	RiPP	streptolysin S	Streptococcus pyogenes M1 GAS
BGC0000495.1	0.44	RiPP	actagardine	Actinoplanes garbadinensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000488.1	0.57	RiPP	circularin A	Clostridium beijerinckii
BGC0001291.1	0.56	RiPP	enterocin NKR-5-3B	Enterococcus faecium
BGC0000504.1	0.54	RiPP	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000523.1	0.52	RiPP	lactocin S	Lactobacillus sakei
BGC0000874.1	0.52	Other	blasticidin S	Streptomyces griseochromogenes
BGC0000500.1	0.52	RiPP	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0001407.1	0.51	RiPP	bicereucin	Bacillus cereus SJ1
BGC0001618.1	0.50	RiPP	hyicin 3682	Staphylococcus hyicus
BGC0000560.1	0.49	RiPP	subtilomycin	Bacillus subtilis
BGC0000514.1	0.49	RiPP	gallidermin	Staphylococcus gallinarum

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

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c00001_NZ_AQFT.. - Region 2 - cyclic-lactone-autoinducer

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Location: 1,833,542 - 1,865,647 nt. (total: 32,106 nt) Show pHMM detection rules used

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000486.1	0.09	RiPP	butyrivibriocin AR10	Butyrivibrio fibrisolvens
BGC0001469.1	0.07	NRP	marthiapeptide A	Brevibacillus sp. Leaf182
BGC0001971.1	0.05	NRP, Polyketide	malyngamide I	Okeania hirsuta
BGC0001970.1	0.05	NRP, Polyketide	malyngamide C acetate	Okeania hirsuta
BGC0000926.1	0.05	Other	rhizocticin A	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000347.1	0.05	NRP	equibactin	Streptococcus equi subsp. equi
BGC0001059.1	0.04	NRP, Polyketide	zwittermicin A	Bacillus cereus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000486.1	0.33	RiPP	butyrivibriocin AR10	Butyrivibrio fibrisolvens
BGC0001469.1	0.29	NRP	marthiapeptide A	Brevibacillus sp. Leaf182
BGC0001971.1	0.24	NRP, Polyketide	malyngamide I	Okeania hirsuta
BGC0001970.1	0.22	NRP, Polyketide	malyngamide C acetate	Okeania hirsuta
BGC0000926.1	0.22	Other	rhizocticin A	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000347.1	0.21	NRP	equibactin	Streptococcus equi subsp. equi
BGC0001059.1	0.17	NRP, Polyketide	zwittermicin A	Bacillus cereus

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

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c00001_NZ_AQFT.. - Region 3 - RRE-containing

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Location: 3,290,027 - 3,309,566 nt. (total: 19,540 nt) Show pHMM detection rules used

RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000519.1	0.16	RiPP	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000551.1	0.16	RiPP	SapB	Streptomyces coelicolor A3(2)
BGC0000513.1	0.16	RiPP	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000501.1	0.15	RiPP	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0000592.1	0.15	RiPP	microviridin B	Microcystis aeruginosa NIES-298
BGC0001496.1	0.15	RiPP	actinokineosin	Actinokineospora spheciospongiae
BGC0001484.1	0.15	Other	2'-chloropentostatin, 2'-amino-2'-deoxyadenosine	Actinomadura sp. ATCC 39365
BGC0000294.1	0.15	NRP	acinetobactin	Acinetobacter baumannii
BGC0001928.1	0.15	Other	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000584.1	0.14	RiPP	colicin V	Escherichia coli

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000519.1	0.47	RiPP	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000551.1	0.47	RiPP	SapB	Streptomyces coelicolor A3(2)
BGC0000513.1	0.46	RiPP	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000501.1	0.46	RiPP	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0000592.1	0.46	RiPP	microviridin B	Microcystis aeruginosa NIES-298
BGC0001496.1	0.45	RiPP	actinokineosin	Actinokineospora spheciospongiae
BGC0001484.1	0.45	Other	2'-chloropentostatin, 2'-amino-2'-deoxyadenosine	Actinomadura sp. ATCC 39365
BGC0000294.1	0.45	NRP	acinetobactin	Acinetobacter baumannii
BGC0001928.1	0.45	Other	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000584.1	0.43	RiPP	colicin V	Escherichia coli

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

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c00001_NZ_AQFT.. - Region 4 - cyclic-lactone-autoinducer

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Location: 3,372,829 - 3,393,319 nt. (total: 20,491 nt) Show pHMM detection rules used

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000486.1	0.09	RiPP	butyrivibriocin AR10	Butyrivibrio fibrisolvens
BGC0000506.1	0.08	RiPP	entianin	Bacillus subtilis subsp. spizizenii
BGC0001791.1	0.05	NRP	sunshinamide	Gynuella sunshinyii YC6258
BGC0000433.1	0.04	NRP	surfactin	Bacillus velezensis FZB42

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000486.1	0.32	RiPP	butyrivibriocin AR10	Butyrivibrio fibrisolvens
BGC0000506.1	0.31	RiPP	entianin	Bacillus subtilis subsp. spizizenii
BGC0001791.1	0.21	NRP	sunshinamide	Gynuella sunshinyii YC6258
BGC0000433.1	0.19	NRP	surfactin	Bacillus velezensis FZB42

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

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c00001_NZ_AQFT.. - Region 5 - ranthipeptide

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Location: 5,586,920 - 5,608,575 nt. (total: 21,656 nt) Show pHMM detection rules used

ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or YcaO or TIGR03882)))

Legend:

core biosynthetic genes

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transport-related genes

regulatory genes

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001441.1	0.13	Other	belactosin A, belactosin C	Streptomyces sp.
BGC0001440.1	0.12	Other	cystargolide A, cystargolide B	Kitasatospora cystarginea
BGC0001562.1	0.08	NRP	curacomycin	Streptomyces curacoi
BGC0001371.1	0.07	NRP	echinocandin B	Aspergillus nidulans NRRL 8112
BGC0000273.1	0.07	Polyketide, Saccharide	steffimycin D	Streptomyces steffisburgensis
BGC0001569.1	0.07	NRP	dechlorocuracomycin	Streptomyces noursei ATCC 11455
BGC0001814.1	0.06	NRP	ulleungmycin	Streptomyces sp. KCB13F003
BGC0000407.1	0.06	NRP	plipastatin	Bacillus subtilis subsp. subtilis
BGC0001035.1	0.05	Other (Aminocoumarin), Polyketide, NRP	pneumocandin B0, pneumocandin A0	Glarea lozoyensis ATCC 20868
BGC0001449.1	0.05	NRP, Polyketide, Alkaloid	ucs1025a	Thermothelomyces thermophilus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001441.1	0.42	Other	belactosin A, belactosin C	Streptomyces sp.
BGC0001440.1	0.39	Other	cystargolide A, cystargolide B	Kitasatospora cystarginea
BGC0001562.1	0.30	NRP	curacomycin	Streptomyces curacoi
BGC0001371.1	0.29	NRP	echinocandin B	Aspergillus nidulans NRRL 8112
BGC0000273.1	0.28	Polyketide, Saccharide	steffimycin D	Streptomyces steffisburgensis
BGC0001569.1	0.28	NRP	dechlorocuracomycin	Streptomyces noursei ATCC 11455
BGC0001814.1	0.25	NRP	ulleungmycin	Streptomyces sp. KCB13F003
BGC0000407.1	0.25	NRP	plipastatin	Bacillus subtilis subsp. subtilis
BGC0001035.1	0.24	Other (Aminocoumarin), Polyketide, NRP	pneumocandin B0, pneumocandin A0	Glarea lozoyensis ATCC 20868
BGC0001449.1	0.23	NRP, Polyketide, Alkaloid	ucs1025a	Thermothelomyces thermophilus

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

Selected features only

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c00001_NZ_AQFT.. - Region 6 - lanthipeptide-class-ii

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Location: 5,708,480 - 5,731,509 nt. (total: 23,030 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

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transport-related genes

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Gene details

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MIBiG comparison

KnownClusterBlast

Lanthipeptides

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000500.1	0.28	RiPP	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000523.1	0.28	RiPP	lactocin S	Lactobacillus sakei
BGC0000499.1	0.26	RiPP	butyrivibriocin OR79	Butyrivibrio fibrisolvens
BGC0000525.1	0.25	RiPP	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000626.1	0.23	RiPP	thuricin	Bacillus thuringiensis
BGC0000532.1	0.23	RiPP	mutacin II	Streptococcus mutans
BGC0000521.1	0.22	RiPP	lacticin 481	Lactococcus lactis subsp. lactis
BGC0000498.1	0.21	RiPP	bovicin HJ50	Streptococcus equinus
BGC0000561.1	0.21	RiPP	thermophilin 1277	Streptococcus thermophilus
BGC0000501.1	0.21	RiPP	catenulipeptin	Catenulispora acidiphila DSM 44928

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000500.1	0.62	RiPP	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000523.1	0.61	RiPP	lactocin S	Lactobacillus sakei
BGC0000499.1	0.59	RiPP	butyrivibriocin OR79	Butyrivibrio fibrisolvens
BGC0000525.1	0.58	RiPP	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000626.1	0.56	RiPP	thuricin	Bacillus thuringiensis
BGC0000532.1	0.56	RiPP	mutacin II	Streptococcus mutans
BGC0000521.1	0.55	RiPP	lacticin 481	Lactococcus lactis subsp. lactis
BGC0000498.1	0.54	RiPP	bovicin HJ50	Streptococcus equinus
BGC0000561.1	0.54	RiPP	thermophilin 1277	Streptococcus thermophilus
BGC0000501.1	0.54	RiPP	catenulipeptin	Catenulispora acidiphila DSM 44928

Similar known gene clusters

No matches found.

Lanthipeptide predictions

Lanthipeptide(s) for ctg1_6666 - Putative Class II

ctg1_6665 leader / core peptide: MDNEKKSQLQEESSDMDILGKKFEDLTQEEMKKIQGS - GDVDhaPEDIGAFDhbDhbILDhbDhaKNPYNCK
ctg1_6670 leader / core peptide: MSKEIKKEKILKEAVENITEEELQEIAAA - GDDhbDhbPEADAGIIFPVDhaQVDhaVLKDhbNVFDhaCKPGPIVC
allorf_5721677_5721811 leader / core peptide: LTISEMAEVQGA - GDMEGELDhbDhbPVCVVIADhbADhaADhaVGLAKDhbFKGKC
allorf_5713018_5713086 leader / core peptide: MLYFLNEILYN - MKNDIDhaHCLGG
allorf_5721592_5721762 leader / core peptide: VAITTHTGVVNSPSISPAPCTSAISEIVKSSNAS - PDDhbDhaFVFCFHLDhaFLFLLFFNFY

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

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Lanthipeptides

Core peptide predictions

ctg1_6665 - Class II

Cleavage pHMM score: 0.10

RODEO score: 0

Monoisotopic mass: 2479.2 Da

Molecular weight: 2480.7 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2498.7 Da N = 1; 2516.8 Da N = 2; 2534.8 Da N = 3; 2552.8 Da N = 4

ctg1_6670 - Class II

Cleavage pHMM score: 2.00

RODEO score: 0

Monoisotopic mass: 3480.8 Da

Molecular weight: 3483.0 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 3501.0 Da N = 1; 3519.0 Da N = 2; 3537.1 Da N = 3; 3555.1 Da N = 4

allorf_5721677_5721811 - Class II

Cleavage pHMM score: 3.10

RODEO score: 0

Monoisotopic mass: 3074.6 Da

Molecular weight: 3076.6 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 3094.6 Da N = 1; 3112.6 Da N = 2; 3130.6 Da N = 3; 3148.7 Da N = 4

allorf_5713018_5713086 - Class II

Cleavage pHMM score: -5.60

RODEO score: 0

Monoisotopic mass: 1155.5 Da

Molecular weight: 1156.3 Da

Number of bridges: 1

allorf_5721592_5721762 - Class II

Cleavage pHMM score: -7.20

RODEO score: 0

Monoisotopic mass: 2696.3 Da

Molecular weight: 2698.1 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2716.1 Da N = 1; 2734.2 Da N = 2