Select genomic region:
Overview
2.1
31.1
49.1

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_AUJE01000002 (original name was: NZ_AUJE01000002.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 2.1 | NRPS | 132,962 | 176,594 |

NZ_AUJE01000035 (original name was: NZ_AUJE01000035.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 31.1 | ranthipeptide | 8,200 | 29,810 |

NZ_AUJE01000053 (original name was: NZ_AUJE01000053.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 49.1 | RiPP-like | 1 | 10,592 | N-tetradecanoyl tyrosine | Other | 6%

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 2.1 | NRPS | 132,962 | 176,594 |
Region 31.1 | ranthipeptide | 8,200 | 29,810 |
Region 49.1 | RiPP-like | 1 | 10,592 | N-tetradecanoyl tyrosine | Other | 6%

No secondary metabolite regions were found in these records:
  NZ_AUJE01000001 (original name was: NZ_AUJE01000001.1)
  NZ_AUJE01000003 (original name was: NZ_AUJE01000003.1)
  NZ_AUJE01000004 (original name was: NZ_AUJE01000004.1)
  NZ_AUJE01000005 (original name was: NZ_AUJE01000005.1)
  NZ_AUJE01000006 (original name was: NZ_AUJE01000006.1)
  NZ_AUJE01000007 (original name was: NZ_AUJE01000007.1)
  NZ_KE384126.1
  NZ_AUJE01000010 (original name was: NZ_AUJE01000010.1)
  NZ_AUJE01000011 (original name was: NZ_AUJE01000011.1)
  NZ_KE384127.1
  NZ_AUJE01000014 (original name was: NZ_AUJE01000014.1)
  NZ_AUJE01000015 (original name was: NZ_AUJE01000015.1)
  NZ_AUJE01000016 (original name was: NZ_AUJE01000016.1)
  NZ_AUJE01000017 (original name was: NZ_AUJE01000017.1)
  NZ_AUJE01000018 (original name was: NZ_AUJE01000018.1)
  NZ_AUJE01000019 (original name was: NZ_AUJE01000019.1)
  NZ_AUJE01000020 (original name was: NZ_AUJE01000020.1)
  NZ_AUJE01000021 (original name was: NZ_AUJE01000021.1)
  NZ_AUJE01000022 (original name was: NZ_AUJE01000022.1)
  NZ_KE384128.1
  NZ_AUJE01000025 (original name was: NZ_AUJE01000025.1)
  NZ_AUJE01000026 (original name was: NZ_AUJE01000026.1)
  NZ_AUJE01000027 (original name was: NZ_AUJE01000027.1)
  NZ_AUJE01000028 (original name was: NZ_AUJE01000028.1)
  NZ_AUJE01000029 (original name was: NZ_AUJE01000029.1)
  NZ_AUJE01000030 (original name was: NZ_AUJE01000030.1)
  NZ_AUJE01000031 (original name was: NZ_AUJE01000031.1)
  NZ_KE384129.1
  NZ_AUJE01000034 (original name was: NZ_AUJE01000034.1)
  NZ_AUJE01000036 (original name was: NZ_AUJE01000036.1)
  NZ_AUJE01000037 (original name was: NZ_AUJE01000037.1)
  NZ_AUJE01000038 (original name was: NZ_AUJE01000038.1)
  NZ_AUJE01000039 (original name was: NZ_AUJE01000039.1)
  NZ_AUJE01000040 (original name was: NZ_AUJE01000040.1)
  NZ_AUJE01000041 (original name was: NZ_AUJE01000041.1)
  NZ_AUJE01000042 (original name was: NZ_AUJE01000042.1)
  NZ_AUJE01000043 (original name was: NZ_AUJE01000043.1)
  NZ_AUJE01000044 (original name was: NZ_AUJE01000044.1)
  NZ_AUJE01000045 (original name was: NZ_AUJE01000045.1)
  NZ_AUJE01000046 (original name was: NZ_AUJE01000046.1)
  NZ_AUJE01000047 (original name was: NZ_AUJE01000047.1)
  NZ_AUJE01000048 (original name was: NZ_AUJE01000048.1)
  NZ_AUJE01000049 (original name was: NZ_AUJE01000049.1)
  NZ_AUJE01000050 (original name was: NZ_AUJE01000050.1)
  NZ_AUJE01000051 (original name was: NZ_AUJE01000051.1)
  NZ_AUJE01000052 (original name was: NZ_AUJE01000052.1)
  NZ_AUJE01000054 (original name was: NZ_AUJE01000054.1)
  NZ_AUJE01000055 (original name was: NZ_AUJE01000055.1)
  NZ_AUJE01000056 (original name was: NZ_AUJE01000056.1)
  NZ_AUJE01000057 (original name was: NZ_AUJE01000057.1)
  NZ_AUJE01000058 (original name was: NZ_AUJE01000058.1)
  NZ_AUJE01000059 (original name was: NZ_AUJE01000059.1)
  NZ_AUJE01000060 (original name was: NZ_AUJE01000060.1)
  NZ_AUJE01000061 (original name was: NZ_AUJE01000061.1)
  NZ_AUJE01000062 (original name was: NZ_AUJE01000062.1)
  NZ_AUJE01000063 (original name was: NZ_AUJE01000063.1)
  NZ_AUJE01000064 (original name was: NZ_AUJE01000064.1)
  NZ_AUJE01000065 (original name was: NZ_AUJE01000065.1)
  NZ_AUJE01000066 (original name was: NZ_AUJE01000066.1)
  NZ_AUJE01000067 (original name was: NZ_AUJE01000067.1)
  NZ_AUJE01000068 (original name was: NZ_AUJE01000068.1)
  NZ_AUJE01000069 (original name was: NZ_AUJE01000069.1)
  NZ_AUJE01000070 (original name was: NZ_AUJE01000070.1)
  NZ_AUJE01000071 (original name was: NZ_AUJE01000071.1)

Compact view
c00002_NZ_AUJE.. - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 132,962 - 176,594 nt. (total: 43,633 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001561.1 |  | 0.34 | NRP | curacomycin | Streptomyces curacoi
BGC0000427.1 |  | 0.34 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0000375.1 |  | 0.33 | NRP | indigoidine | Streptomyces chromofuscus
BGC0000900.1 |  | 0.32 | Other | ferrichrome | Aspergillus oryzae
BGC0001249.1 |  | 0.31 | NRP | dimethylcoprogen | Alternaria alternata
BGC0000348.1 |  | 0.31 | NRP | ergovaline | Epichloe festucae var. lolii
BGC0000876.1 |  | 0.27 | Other | neopolyoxin C | Streptomyces tendae
BGC0001399.1 |  | 0.26 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0001479.1 |  | 0.26 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0000727.1 |  | 0.25 | Saccharide | indigoidine | Streptomyces aureofaciens

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001561.1 |  | 0.67 | NRP | curacomycin | Streptomyces curacoi
BGC0000427.1 |  | 0.67 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0000375.1 |  | 0.67 | NRP | indigoidine | Streptomyces chromofuscus
BGC0000900.1 |  | 0.66 | Other | ferrichrome | Aspergillus oryzae
BGC0001249.1 |  | 0.65 | NRP | dimethylcoprogen | Alternaria alternata
BGC0000348.1 |  | 0.65 | NRP | ergovaline | Epichloe festucae var. lolii
BGC0000876.1 |  | 0.61 | Other | neopolyoxin C | Streptomyces tendae
BGC0001399.1 |  | 0.59 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0001479.1 |  | 0.59 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0000727.1 |  | 0.59 | Saccharide | indigoidine | Streptomyces aureofaciens

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 132961 - 176594:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg2_141: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (216..611): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DGgdvGEVsK
    Nearest Stachelhaus code:
      leu
    Stachelhaus code match:
      60% (weak)

c00031_NZ_AUJE.. - Region 1 - ranthipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 8,200 - 29,810 nt. (total: 21,611 nt) Show pHMM detection rules used
ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or YcaO or TIGR03882)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | ranthipeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000466.1 |  | 0.17 | NRP | yatakemycin | Streptomyces sp. TP-A2060
BGC0000780.1 |  | 0.17 | Saccharide | O&K-antigen | Vibrio parahaemolyticus
BGC0001973.1 |  | 0.13 | Other | fervenulin | Streptomyces hiroshimensis
BGC0001972.1 |  | 0.13 | Other | toxoflavin, fervenulin | Streptomyces hiroshimensis
BGC0000807.1 |  | 0.09 | Saccharide | phosphonoglycans | Stackebrandtia nassauensis DSM 44728
BGC0001191.1 |  | 0.07 | Other | A-102395 | Amycolatopsis sp. SANK 60206
BGC0000678.1 |  | 0.06 | Terpene | pentalenolactone | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001995.1 |  | 0.06 | Terpene | heptelidic acid | Aspergillus oryzae RIB40
BGC0000949.1 |  | 0.06 | NRP | A-500359 A, A-500359 B | Streptomyces griseus
BGC0000225.1 |  | 0.04 | Polyketide | frenolicin B | Streptomyces roseofulvus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000466.1 |  | 0.48 | NRP | yatakemycin | Streptomyces sp. TP-A2060
BGC0000780.1 |  | 0.48 | Saccharide | O&K-antigen | Vibrio parahaemolyticus
BGC0001973.1 |  | 0.41 | Other | fervenulin | Streptomyces hiroshimensis
BGC0001972.1 |  | 0.41 | Other | toxoflavin, fervenulin | Streptomyces hiroshimensis
BGC0000807.1 |  | 0.33 | Saccharide | phosphonoglycans | Stackebrandtia nassauensis DSM 44728
BGC0001191.1 |  | 0.28 | Other | A-102395 | Amycolatopsis sp. SANK 60206
BGC0000678.1 |  | 0.26 | Terpene | pentalenolactone | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001995.1 |  | 0.26 | Terpene | heptelidic acid | Aspergillus oryzae RIB40
BGC0000949.1 |  | 0.25 | NRP | A-500359 A, A-500359 B | Streptomyces griseus
BGC0000225.1 |  | 0.20 | Polyketide | frenolicin B | Streptomyces roseofulvus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00049_NZ_AUJE.. - Region 1 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 10,592 nt. (total: 10,592 nt) Show pHMM detection rules used
Region on contig edge.
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001687.1 |  | 0.05 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSL12
BGC0001090.1 |  | 0.04 | NRP, Polyketide | bacillomycin D | Bacillus velezensis FZB42
BGC0001098.1 |  | 0.04 | NRP, Polyketide | iturin | Bacillus subtilis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001687.1 |  | 0.23 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSL12
BGC0001090.1 |  | 0.18 | NRP, Polyketide | bacillomycin D | Bacillus velezensis FZB42
BGC0001098.1 |  | 0.18 | NRP, Polyketide | iturin | Bacillus subtilis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names