LOCUS       NZ_LR025744.1          10816 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_LR025744.1 Burkholderia stabilis isolate E chromosome III,
            complete sequence.
ACCESSION   NZ_LR025744
VERSION     NZ_LR025744.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 14:38:37
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 921977
            Orig. end    :: 932793
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10816
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[926977:927793](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5816)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10816
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10816
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="4"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(1144..3990)
                     /gene_functions="other (smcogs) SMCOG1223:ATPase (Score:
                     1001.6; E-value: 4.8e-303)"
                     /gene_kind="other"
                     /locus_tag="ctg3_794"
                     /transl_table=11
                     /translation="MPALCDICHARPAVARATVMQDGERKTISICDYHFRQLMRHQSML
                     NPFDSLLGGGGSSSLFGELGDESPLAAEVPRESVDPTDAFSEQTLELLQRAAEKAHELR
                     RSELDSEHLLYALADTDVCAALLKELKLSPQDIKSYIDEHAHTGTADPDAPLDKLSISP
                     RVKKAVQYAFQASRDLGHSYIGPEHLLIGLASVPDSIAGTLLKKYGVTPEALRQKVVKV
                     VGKGAEDGRVDAPTGTPNLDKFGRDLTAIARQGKLDPVLGRAQEIESTIEVLARRKKNN
                     PVLIGEPGVGKTAIVEGLAQRIVNGDVPEVLRNKRLVEVNINSMVAGAKYRGEFEERAK
                     QLIDEVTAKQDELILFIDELHTIVGAGQGGGEGGLDIANVLKPALARGELSLIGATTLN
                     EYQKYIEKDAALERRFQPVFVPEPSVEQTIVILRGLRDSLEAHHQVTFADDAFVAAAEF
                     ADRYITSRFLPDKAIDLIDQAAARVRIGATSRPVDIQEGEAQIAQLKREQDYATSRKRF
                     DEAKQFEEQINEKQKAVDEKMEAWQRKTGSETLEVTVEAVAEVVSRLTGIPVSELTQEE
                     RQKLLKMEEQLRERVVGQSDAVVAVSDAVRLSRAGLGQTHRPIATFLFLGPTGVGKTEL
                     AKALAETVFGDEQAIIRIDMSEYMERHAVARLIGAPPGYVGYDEGGQLTERVRRRPYSV
                     ILLDEIEKAHPDVYNVLLQVFDDGRLTDGKGRVVDFSNTIIIATSNLGAAIIMDNLTQP
                     EAARKTDKAIREELMQVLKGHFRPEFLNRIDEVIVFHALSKDNIRSIVQIQLDRVVRTA
                     AAQDITLVMGDALVDHLTEAGYQPEFGARELKRQIRQTIETKLAKEILADRLKSGDHVE
                     VDYDKDNDEVKFDKIAAPEAKDTKDAKKDADGKAKPNGKAAAKASGEAKAGEAPADAPP
                     PAAKPSGKKSSGSKKDAH"
     PFAM_domain     complement(1375..1617)
                     /aSDomain="ClpB_D2-small"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF10431.11"
                     /description="C-terminal, D2-small domain, of ClpB protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_794_0084"
                     /evalue="1.00E-21"
                     /label="ctg3_794"
                     /locus_tag="ctg3_794"
                     /protein_end="872"
                     /protein_start="791"
                     /score="76.8"
                     /tool="antismash"
                     /translation="LSKDNIRSIVQIQLDRVVRTAAAQDITLVMGDALVDHLTEAGYQP
                     EFGARELKRQIRQTIETKLAKEILADRLKSGDHVEV"
     PFAM_domain     complement(1633..2142)
                     /aSDomain="AAA_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07724.16"
                     /description="AAA domain (Cdc48 subfamily)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_794_0083"
                     /evalue="1.30E-54"
                     /label="ctg3_794"
                     /locus_tag="ctg3_794"
                     /protein_end="786"
                     /protein_start="616"
                     /score="185.0"
                     /tool="antismash"
                     /translation="RPIATFLFLGPTGVGKTELAKALAETVFGDEQAIIRIDMSEYMER
                     HAVARLIGAPPGYVGYDEGGQLTERVRRRPYSVILLDEIEKAHPDVYNVLLQVFDDGRL
                     TDGKGRVVDFSNTIIIATSNLGAAIIMDNLTQPEAARKTDKAIREELMQVLKGHFRPEF
                     LNRIDEV"
     PFAM_domain     complement(2416..2721)
                     /aSDomain="AAA_lid_9"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF17871.3"
                     /description="AAA lid domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_794_0082"
                     /evalue="1.10E-30"
                     /label="ctg3_794"
                     /locus_tag="ctg3_794"
                     /protein_end="525"
                     /protein_start="423"
                     /score="105.7"
                     /tool="antismash"
                     /translation="SVEQTIVILRGLRDSLEAHHQVTFADDAFVAAAEFADRYITSRFL
                     PDKAIDLIDQAAARVRIGATSRPVDIQEGEAQIAQLKREQDYATSRKRFDEAKQFEE"
     PFAM_domain     complement(2743..3144)
                     /aSDomain="AAA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00004.31"
                     /description="ATPase family associated with various
                     cellular activities (AAA)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_794_0081"
                     /evalue="3.50E-14"
                     /label="ctg3_794"
                     /locus_tag="ctg3_794"
                     /protein_end="416"
                     /protein_start="282"
                     /score="53.5"
                     /tool="antismash"
                     /translation="VLIGEPGVGKTAIVEGLAQRIVNGDVPEVLRNKRLVEVNINSMVA
                     GAKYRGEFEERAKQLIDEVTAKQDELILFIDELHTIVGAGQGGGEGGLDIANVLKPALA
                     RGELSLIGATTLNEYQKYIEKDAALERRFQ"
     PFAM_domain     complement(3319..3477)
                     /aSDomain="Clp_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02861.22"
                     /description="Clp amino terminal domain, pathogenicity
                     island component"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_794_0080"
                     /evalue="5.70E-16"
                     /label="ctg3_794"
                     /locus_tag="ctg3_794"
                     /protein_end="224"
                     /protein_start="171"
                     /score="58.5"
                     /tool="antismash"
                     /translation="AFQASRDLGHSYIGPEHLLIGLASVPDSIAGTLLKKYGVTPEALR
                     QKVVKVVG"
     PFAM_domain     complement(3562..3705)
                     /aSDomain="Clp_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02861.22"
                     /description="Clp amino terminal domain, pathogenicity
                     island component"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_794_0079"
                     /evalue="8.20E-06"
                     /label="ctg3_794"
                     /locus_tag="ctg3_794"
                     /protein_end="143"
                     /protein_start="95"
                     /score="25.9"
                     /tool="antismash"
                     /translation="AAEKAHELRRSELDSEHLLYALADTDVCAALLKELKLSPQDIKSY
                     IDE"
     CDS             complement(4626..4895)
                     /locus_tag="ctg3_795"
                     /transl_table=11
                     /translation="MSDTNDALQALQASVDSLKKTVDANAGSQAGDTAVLFTVVSLMLA
                     ELPPDTRNLIEDSFSVWANGLPNAALSTDVKQIARQRLAMKLPD"
     CDS             complement(5001..5816)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Linocin_M18"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg3_796"
                     /sec_met_domain="Linocin_M18 (E-value: 5.5e-94, bitscore:
                     310.1, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNLHRELAPISSSAWEQIEEEVARTFKRSVAGRRVVDVDGPEGP
                     ELSAVGTGHLVEVAAPREHVNARLREVRTIVELTVPFELSRDAIDSVERGARDADWQPA
                     KDAAQRLAFAEDNAIFDGYPAAGIVGIREGTSNRKLTLPADVSAYPDAISDALEALRLA
                     GVDGPYSVVLGSDAYTALSEARDQGYPVLGHIKRIVSGEIIWAPAISGGCVLSMRGGDY
                     ELHLGEDVSIGYTSHTDKAVRLYLRETFTFLMLTSEASVAVAPQGNPAA"
     PFAM_domain     complement(5064..5816)
                     /aSDomain="Linocin_M18"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04454.14"
                     /description="Encapsulating protein for peroxidase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_796_0085"
                     /evalue="1.40E-93"
                     /label="ctg3_796"
                     /locus_tag="ctg3_796"
                     /protein_end="251"
                     /protein_start="0"
                     /score="313.0"
                     /tool="antismash"
                     /translation="MNNLHRELAPISSSAWEQIEEEVARTFKRSVAGRRVVDVDGPEGP
                     ELSAVGTGHLVEVAAPREHVNARLREVRTIVELTVPFELSRDAIDSVERGARDADWQPA
                     KDAAQRLAFAEDNAIFDGYPAAGIVGIREGTSNRKLTLPADVSAYPDAISDALEALRLA
                     GVDGPYSVVLGSDAYTALSEARDQGYPVLGHIKRIVSGEIIWAPAISGGCVLSMRGGDY
                     ELHLGEDVSIGYTSHTDKAVRLYLRETFT"
     CDS             complement(5809..6876)
                     /locus_tag="ctg3_797"
                     /transl_table=11
                     /translation="MTDRQPAMQTPPPLSQAVHSPITRSAIFLVATINSGADHADTIRS
                     WCGDIAALVRSVGKRVPGGNLSCVCGFGADAWDALFGGPRPASLHSFREFGAGQRVAVA
                     TPGDILLHIRADAMDLCFELATQLLGALGEAVTVVDEVHGFRNFDQRAMIGFVDGTENP
                     EGREAVDFTVIGDEDAEFTGGSYVIVQKYLHDMAGWNALAVETQERIIGRTKLSDIELA
                     PNVKPSCSHSSLTTLDENGQEVKILRDNMPFGRPGAGEFGTYFIGYARSPAPIEQMLEN
                     MFVGRPPGNYDRLLDYSRAVTGSLFFVPSADLLEALADRAAPAADAAPPEPLSSAPHRD
                     GSLKIGSLKGTQAHE"
     aSDomain        complement(5941..6828)
                     /aSDomain="TIGR01413"
                     /aSTool="tigrfam"
                     /description="Dyp_perox_fam: Dyp-type peroxidase family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg3_797_0011"
                     /evalue="1.00E-84"
                     /identifier="TIGR01413"
                     /label="ctg3_797"
                     /locus_tag="ctg3_797"
                     /protein_end="312"
                     /protein_start="16"
                     /score="282.6"
                     /tool="antismash"
                     /translation="AVHSPITRSAIFLVATINSGADHADTIRSWCGDIAALVRSVGKRV
                     PGGNLSCVCGFGADAWDALFGGPRPASLHSFREFGAGQRVAVATPGDILLHIRADAMDL
                     CFELATQLLGALGEAVTVVDEVHGFRNFDQRAMIGFVDGTENPEGREAVDFTVIGDEDA
                     EFTGGSYVIVQKYLHDMAGWNALAVETQERIIGRTKLSDIELAPNVKPSCSHSSLTTLD
                     ENGQEVKILRDNMPFGRPGAGEFGTYFIGYARSPAPIEQMLENMFVGRPPGNYDRLLDY
                     SRAVTGSLFFVPSAD"
     PFAM_domain     complement(5941..6831)
                     /aSDomain="Dyp_perox"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04261.14"
                     /description="Dyp-type peroxidase family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_797_0086"
                     /evalue="8.80E-90"
                     /label="ctg3_797"
                     /locus_tag="ctg3_797"
                     /protein_end="312"
                     /protein_start="15"
                     /score="301.1"
                     /tool="antismash"
                     /translation="QAVHSPITRSAIFLVATINSGADHADTIRSWCGDIAALVRSVGKR
                     VPGGNLSCVCGFGADAWDALFGGPRPASLHSFREFGAGQRVAVATPGDILLHIRADAMD
                     LCFELATQLLGALGEAVTVVDEVHGFRNFDQRAMIGFVDGTENPEGREAVDFTVIGDED
                     AEFTGGSYVIVQKYLHDMAGWNALAVETQERIIGRTKLSDIELAPNVKPSCSHSSLTTL
                     DENGQEVKILRDNMPFGRPGAGEFGTYFIGYARSPAPIEQMLENMFVGRPPGNYDRLLD
                     YSRAVTGSLFFVPSAD"
     CDS             7254..7613
                     /gene_functions="regulatory (smcogs) SMCOG1031:LysR family
                     transcriptional regulator (Score: 60.8; E-value: 2.3e-18)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg3_798"
                     /transl_table=11
                     /translation="MNLLEAMRVYVAVVEHGGVAGAASELKLGEAQVSDRIDCLERYLD
                     CRLLQCRERGYVACTDTGVAFHVCCRRTLSAVEQATGAALTRKTDARDCADDTAHCPDF
                     PPPSAAHASSHRPSP"
     PFAM_domain     7263..7442
                     /aSDomain="HTH_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00126.29"
                     /description="Bacterial regulatory helix-turn-helix
                     protein, lysR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_798_0087"
                     /evalue="5.60E-11"
                     /label="ctg3_798"
                     /locus_tag="ctg3_798"
                     /protein_end="63"
                     /protein_start="3"
                     /score="42.3"
                     /tool="antismash"
                     /translation="LEAMRVYVAVVEHGGVAGAASELKLGEAQVSDRIDCLERYLDCRL
                     LQCRERGYVACTDTG"
     CDS             8091..9077
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1172:methionine aminopeptidase (Score: 158.8; E-value:
                     3.3e-48)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg3_799"
                     /transl_table=11
                     /translation="MNLPLDTRLRSARSDSPSCCVLGLTHQVVAIGRFDIATYVQLESA
                     RYNMSHNVDYNEISIKTPEEIAMLRAAGRIAAQVLQDLTPHIQPGVTSRQINDIAYDLI
                     VNKYHAEIDREDLSGYDSSEYACISIAHNENAFSGEPNDLPLKKGDLFGVDVSIKKEGW
                     CGDTQRMWIVGEETSAEARLLMAVGYQAMCLGISLVRPGAAVQDIARRVQAYVESFGFS
                     MLRVPSGTGHSIGQVHADGWLIPYYESSVNEGRVLEKGMVITVEPFICAGSGEGIRLNN
                     VTRSAQTADKSLAVYWEHVVAVTESGCEVLDLRDGEDVTFYDARPRG"
     PFAM_domain     8292..9005
                     /aSDomain="Peptidase_M24"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00557.26"
                     /description="Metallopeptidase family M24"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_799_0088"
                     /evalue="6.90E-36"
                     /label="ctg3_799"
                     /locus_tag="ctg3_799"
                     /protein_end="305"
                     /protein_start="67"
                     /score="124.0"
                     /tool="antismash"
                     /translation="MLRAAGRIAAQVLQDLTPHIQPGVTSRQINDIAYDLIVNKYHAEI
                     DREDLSGYDSSEYACISIAHNENAFSGEPNDLPLKKGDLFGVDVSIKKEGWCGDTQRMW
                     IVGEETSAEARLLMAVGYQAMCLGISLVRPGAAVQDIARRVQAYVESFGFSMLRVPSGT
                     GHSIGQVHADGWLIPYYESSVNEGRVLEKGMVITVEPFICAGSGEGIRLNNVTRSAQTA
                     DKSLAVYWEHVVAVTE"
     CDS             complement(9074..10003)
                     /gene_functions="regulatory (smcogs) SMCOG1031:LysR family
                     transcriptional regulator (Score: 207.2; E-value: 5.9e-63)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg3_800"
                     /transl_table=11
                     /translation="MTDRIRFNFSALRALETAERSRSFTAAANELSLTHSAISHQIRQI
                     ESMLGISLFTRTQSQMIPTPACTHLAERVRQGLADIECALLEARDADRQQRLVLKVSVM
                     ADFATAWLIPELDVFYSRYPHLDLSIAVRNTLDVPEGHESDIGIWHKSIDRNGFQSRKL
                     LDDQVIAACTPAFLDKHRPLTVTDLARVPLLRFSGRSWREFFHAANLVAGDPEYGPMFN
                     DAASLLQAALAGQGVAMLRERLIRSYLQEGKLVQVGSTRIPSNLAYYLCWREGDPKQDA
                     ILQFVAWLEEMVQQKDRDSLAQDKTVVP"
     PFAM_domain     complement(9128..9724)
                     /aSDomain="LysR_substrate"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03466.22"
                     /description="LysR substrate binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_800_0090"
                     /evalue="1.10E-31"
                     /label="ctg3_800"
                     /locus_tag="ctg3_800"
                     /protein_end="292"
                     /protein_start="93"
                     /score="110.0"
                     /tool="antismash"
                     /translation="QQRLVLKVSVMADFATAWLIPELDVFYSRYPHLDLSIAVRNTLDV
                     PEGHESDIGIWHKSIDRNGFQSRKLLDDQVIAACTPAFLDKHRPLTVTDLARVPLLRFS
                     GRSWREFFHAANLVAGDPEYGPMFNDAASLLQAALAGQGVAMLRERLIRSYLQEGKLVQ
                     VGSTRIPSNLAYYLCWREGDPKQDAILQFVAWLEEM"
     PFAM_domain     complement(9806..9976)
                     /aSDomain="HTH_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00126.29"
                     /description="Bacterial regulatory helix-turn-helix
                     protein, lysR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_800_0089"
                     /evalue="8.00E-16"
                     /label="ctg3_800"
                     /locus_tag="ctg3_800"
                     /protein_end="66"
                     /protein_start="9"
                     /score="57.9"
                     /tool="antismash"
                     /translation="SALRALETAERSRSFTAAANELSLTHSAISHQIRQIESMLGISLF
                     TRTQSQMIPTPA"
ORIGIN
        1 gctcgcgcgc tcgatgtcgt cccacgacgt ggcctgcagg tcggccgaga acgcgtcgaa
       61 gccgtcggtg tgctgcgcga tgaagtcgcg gtcgagcacg tcgccgcgct cggcttcgag
      121 ctgcagcagc gccttcatga tgcccttcag cgcggctgcg tcgccgccgg cgtcgacctg
      181 gtagtacgtc gatgcgatcc gcgtcgagcc gaacgacgcc atctcgatca tgtcctgtgg
      241 gtccgcgaag cgttcgagcg cgcgttcgcg cagcggattg aacacgatga tcggcacgtg
      301 gcggcgcgcg cactcgtgca gcgtgcccat catccgcggg tggttcgtgc cggggttgtg
      361 gccgatcgag atgatcagct cgcactggtc gaaatcttcc agcgacacgg tgcccttgcc
      421 gatgccgatc gactgcggca gcccgacgct ggtcggctcg tggcacatgt tcgagcagtc
      481 ggggaagttg ttggtgccga gctcgcgcgc gaacagctgg tacaggtacg cggcttcgtt
      541 cgacgcgcgg cccgacgtat agaactccac ctgctcgggc ggcagtgcgc gcagcacttc
      601 gccgatgcgc gcgaacgcgt cgtcccattc gatcgcgcgg aacgtgtcgg tcgcgcgatc
      661 gtagacgagc gggtgcgtga gccgccccat gttctccagt tcgtaatccg acatgcgcag
      721 cagcgacgac acggtgttcg ccgcgaagaa ctcgggtggc acgcgcttgg tcgtcgcttc
      781 ccacgtgacg gccttcgcgc cgttctcgca gaactggaac gtcgacttgt gttccttgtc
      841 cggccaggcg cagccggggc agtcgaaacc gtcgggctgg ttggtccgca tcagcacgat
      901 cggcgcctcg atggtttcca tctgcgtgcg cacggcctcg gctgtcgcgc gaagcgcgcc
      961 ccaaccgccg gcgggcccat cgtacttcct gatgcctggc acttcgcgtc gatttgtcat
     1021 gtgaatctcc atgagccggc ccggtgcggg cggctcgggt tgcgccgcgt cgcggcgtag
     1081 ggcggctccg tccggtggac ggagccggtc atgcgagccc cgggctgcag ggcaggcggg
     1141 gtttcagtgc gcgtccttct tcgagccgga cgactttttg ccagacggtt tcgccgcggg
     1201 cggcggcgcg tcggccggcg cctcgccggc cttcgcttca cctgatgcct tggcggccgc
     1261 cttgccgttc ggcttcgcct tgccgtcggc gtccttcttc gcgtccttcg tgtccttcgc
     1321 ttccggcgcg gcgatcttgt cgaacttcac ttcgtcgttg tccttgtcgt agtcgacctc
     1381 gacgtggtcg cccgacttca gccggtcggc gaggatctcc ttcgcgagct tggtctcgat
     1441 cgtctggcgg atctgacgct tcagctcgcg cgcgccgaac tccggctggt agccggcttc
     1501 ggtcaggtgg tcgacgagcg catcgcccat cacgagcgtg atgtcctgcg cggcggccgt
     1561 gcgcaccacg cggtcgagct ggatctgcac gatcgagcgg atgttgtcct tcgacagcgc
     1621 atggaagacg atcacctcgt cgatccggtt caggaactcg gggcggaagt ggcccttcag
     1681 cacctgcatc agctcctcgc ggatcgcctt gtcggtcttg cgcgcggctt ccggttgcgt
     1741 gaggttgtcc atgatgatcg ccgcgccgag gttgctcgtc gcgatgatga tcgtgttgct
     1801 gaagtcgacc acgcggccct tgccgtcggt caggcggcca tcgtcgaaca cctgcagcag
     1861 cacgttgtag acgtccgggt gcgccttctc gatctcgtcg agcaggatca cgctgtacgg
     1921 gcggcgccgc acgcgctcgg tgagctggcc gccttcgtcg tagccgacgt agccgggcgg
     1981 cgcgccgatc agccgcgcga ccgcgtgccg ttccatgtat tcggacatgt cgatgcggat
     2041 gatcgcctgc tcgtcgccga acacggtctc ggccagcgcc ttcgcgagct cggtcttgcc
     2101 gacgcccgtc ggcccgagga acaggaacgt cgcgatcggc cggtgcgtct ggccgagccc
     2161 cgcgcgcgac agccgcacgg cgtcgctgac ggcgaccacc gcgtcgctct ggccgaccac
     2221 gcgctcgcgc agctgctctt ccatcttcag cagcttctgg cgttcttcct gcgtgagttc
     2281 ggacacgggg atgccggtca gccgcgacac cacttcggcc acggcttcga cggtcacttc
     2341 gagcgtctcg gagccggtct tgcgctgcca cgcttccatc ttttcatcga ccgccttctg
     2401 cttctcgttg atctgctctt cgaactgctt cgcttcgtcg aagcgcttgc gcgaggtcgc
     2461 gtagtcctgt tcgcgcttca gttgcgcgat ctgcgcttcg ccttcctgaa tatcgaccgg
     2521 gcgcgacgtc gcgccgatcc gcacgcgtgc ggcggcctgg tcgatcaggt cgatcgcctt
     2581 gtcgggcagg aagcgcgacg tgatgtagcg gtcggcgaat tcggcggcgg cgacgaatgc
     2641 gtcgtcggcg aacgtcacct ggtggtgcgc ctcgaggctg tcgcgcagcc cgcgcaggat
     2701 cacgatcgtc tgctcgacgc tcggctccgg cacgaacacc ggctggaagc gccgttcgag
     2761 cgccgcgtcc ttctcgatgt acttctggta ttcgttgagc gtcgtcgcgc cgatcaggct
     2821 cagctcgccg cgcgcgagcg cgggcttcag cacgttcgcg atatcgaggc cgccttcgcc
     2881 gccgccctgg ccggcaccga cgatcgtgtg cagctcgtcg atgaacagga tcagttcgtc
     2941 ctgcttcgcg gtcacttcgt cgatcagctg cttcgcgcgc tcctcgaatt cgcctcgata
     3001 cttcgcaccg gccaccatcg agttgatgtt gacttcgacg agccgcttgt tgcgcagcac
     3061 ctcgggcacg tcgccgttga cgatccgctg cgcaagccct tcgacgatcg ccgtcttgcc
     3121 gacgcccggc tcgccgatca gcaccgggtt gttcttcttg cggcgcgcga gcacctcgat
     3181 cgtgctctcg atttcctgcg cgcggccgag caccgggtcg agcttgccct ggcgtgcgat
     3241 cgcggtgagg tcgcggccaa acttgtcgag gttcggcgtg ccggtcggcg catcgacgcg
     3301 gccgtcctcg gcgcccttgc cgaccacctt gacgactttc tggcgcagcg cctcgggcgt
     3361 cacgccgtat ttcttcaaca gcgtaccggc gatgctgtcc ggcaccgacg cgaggccgat
     3421 cagcaggtgc tcggggccga tgtacgagtg gccgagatcg cgcgacgcct ggaacgcgta
     3481 ctgcacggcc ttcttcacgc gcggggagat cgacagcttg tcgagcggcg catcggggtc
     3541 ggccgtgccg gtgtgcgcgt gctcgtcgat atacgacttg atgtcctgcg gcgacagctt
     3601 cagttccttc agcagcgcgg cgcacacgtc ggtgtccgcg agcgcgtaga gcaggtgttc
     3661 ggaatcgagc tcgctgcggc gcagctcgtg cgctttttcg gccgcgcgct gcagtagttc
     3721 gagcgtctgt tcgctgaacg cgtcggtcgg gtcgaccgac tcacgcggta cttcggcggc
     3781 gagtggcgat tcgtcgccga gctcgccgaa cagcgacgac gagccgcctc cgcccagcag
     3841 cgaatcgaac gggttcagca tgctttgatg ccgcatcagc tgacggaagt ggtaatcgca
     3901 gatcgaaatc gtcttgcgct cgccgtcctg catcacggtt gcgcgcgcga cggccggccg
     3961 cgcgtggcag atatcgcaaa gtgcgggcat ggtggtctgg ctcctgtctg tgaaggtggg
     4021 tcgaagggtg aagtcccgat gcggtgcggc gctcgcgcgt cccgaccgag aacagacgac
     4081 gcgcggcgcg gcggcgcgcg tgccgcgccc gcgctgtcgc gcagtgcgcg ccggcgtcgt
     4141 gcacggtcgc ggtcgcggcg gggagcacga gtgctgcgag gagcccacgg catcgcttcg
     4201 actgcattca aaatagcgaa tcggcggggg gcatccaaga cacagttccg tgccggaccc
     4261 acggcgaatt gcaccctcac atgcgtgcgc gtacgggcgg caaggagtac agacgggcgc
     4321 gcatgcggtg gcgcggccgt gcgcggcgtg tgtcgtgcgc gttggccgga agcggggagc
     4381 agcggaacgg gaagggatcg cggtgcgaca tcggcgcgca gggcgcgggc cggcagcagg
     4441 cgggcggtga tgcgggggga caaccgcggc acgagcgccg cggtgtgagc gcgtgcgccg
     4501 caggcgtgcg cgaagtggtc acgaccggcc acgcgcacac cgcagccgat gcgtgcgtgg
     4561 cagccggagg agcggtcggg ttgcacggtg cgggccggac atggcgcaac cgtggagaac
     4621 cgcgatcagt ccgggagttt catcgcgagc cgctgccggg caatctgctt cacgtcggtt
     4681 gacagtgccg catttggcag accattggcc cacacggaga acgaatcctc gatcaggttg
     4741 cgcgtgtcgg gcggcaactc ggccagcatc agcgacacga cggtaaacag cacggcggtg
     4801 tcgccggcct ggctgcccgc gttcgcatcg accgtcttct tcaggctgtc gaccgacgct
     4861 tgcagcgcct gcagtgcatc attcgtatcg ctcatgacac tctccatgca agatgggttc
     4921 aatcggcgac gaacatgcgg ccggcggcgc ggcctgtcgc gcgcgacgcc cgggcgggca
     4981 tcgcgcgcag gcaaccgggg tcaggccgcc ggattgccct gcggcgccac ggccaccgat
     5041 gcttcgctcg tcagcatcag gaacgtgaac gtttcgcgca ggtacaggcg gacggccttg
     5101 tcggtatggc tcgtgtagcc gatcgatacg tcttccccga ggtgcagctc gtaatcgccg
     5161 ccgcgcatgg acagcacgca gccgccgctg atcgccggcg cccagatgat ctcgccgctg
     5221 acgatgcgtt tgatgtgacc gaggaccgga taaccctggt cgcgcgcctc gctgagcgcg
     5281 gtataggcgt ccgagccgag cacgaccgag tacgggccgt cgacgccggc gagccgcagc
     5341 gcttcgagcg cgtcgctgat cgcgtccggg tacgcgctga cgtcggccgg cagcgtgagc
     5401 ttgcggttcg acgtgccttc gcggatgccg acgatgccgg ccgccggata gccgtcgaaa
     5461 atcgcgttgt cttcggcgaa cgcgagccgc tgcgcggcgt ccttcgccgg ttgccagtcg
     5521 gcatcgcgcg cgccgcgctc gacgctgtcg atcgcatcgc ggctcaactc gaacggcacc
     5581 gtcagctcga cgatcgtgcg gacttcgcgc agccgcgcgt tcacgtgctc gcgcggcgcg
     5641 gcgacttcca ccagatgccc ggtgccgacg gccgacagct cggggccttc ggggccgtcg
     5701 acgtcgacga cgcggcggcc ggccaccgat cgtttgaagg tgcgcgccac ttcctcctcg
     5761 atttgttccc aggcggacga cgagatcggg gcgagttcgc ggtgcagatt attcatgggc
     5821 ttgggttcct ttcagcgagc cgattttcag cgagccgtcg cgatgcggcg cggacgacaa
     5881 gggttcgggg ggcgcggcgt cggcggcagg cgccgcgcga tcggcgagcg cttcgagcag
     5941 gtcggccgac ggcacgaaga acagcgagcc ggtgaccgcg cggctgtagt cgagcaggcg
     6001 gtcgtagttg ccgggagggc ggccgacgaa catgttctcg agcatctgtt cgatcggcgc
     6061 gggcgagcgc gcatagccga tgaaataggt gccgaactcg ccggcgcccg ggcgcccgaa
     6121 cggcatgttg tcgcgcagga tcttcacttc ctggccgttc tcgtcgagcg tggtcagcga
     6181 gctgtgcgaa cacgacggct tcacgttcgg cgcgagctcg atgtcggaca atttggtgcg
     6241 gccgatgatg cgctcctgcg tctcgaccgc gagcgcgttc cagccggcca tgtcgtgcag
     6301 gtatttctgc acgatcacgt agctgccgcc ggtgaactcc gcgtcttcgt cgccgatcac
     6361 cgtgaagtcg accgcctcgc ggccttccgg gttctcggtg ccgtcgacga agccgatcat
     6421 cgcgcgctgg tcgaagttgc ggaagccgtg cacctcgtcg acgaccgtga cggcttcacc
     6481 gagcgcgccg agcagttgcg tcgcgagctc gaagcagagg tccatcgcat cggcgcggat
     6541 gtgcagcagg atgtcgccgg gtgtcgcgac cgcgacgcgc tggcctgcgc cgaactcgcg
     6601 gaacgagtgc agcgacgccg ggcgcgggcc gccgaacagc gcgtcccatg cgtcggcgcc
     6661 gaagccgcag acgcacgaca ggttgccgcc cggcacgcgc ttgccgaccg agcgcaccag
     6721 cgcggcgatg tcgccgcacc atgaacggat cgtgtcggcg tgatcggcgc cggaattgat
     6781 cgtcgccacg aggaagatcg cgctgcgcgt gatcgggctg tgaacggcct gggagagtgg
     6841 gggaggtgtc tgcatcgcgg gctgccggtc agtcatgtcg ggacggacgg gccacggctg
     6901 ccgcggcgcg cgagggcgaa cggttgaact gtgtcatgcg actcttctct ttgtgacatg
     6961 cggatgaagg acgttgcgcg ggcctcgcgc aacgggccgc ggcagcggcg gccggccgcc
     7021 cggcgcgtga actgcgcgca ccgcgtaacg tcgtcgagca tgcaatctag cagcttcggc
     7081 gggtctttgg aacacgtatc gacaatctgt cattcgaatc cgtcaaacag gcccggattt
     7141 tgcgcaacgc ccgcgcagct gtactcctgg ggcgcgcggc gctgtgctct tgagcgcgcg
     7201 tgcggcgtgc agtagattag gttccgctgc gcccgccgac gaggagcgtc atcatgaacc
     7261 tgctggaagc gatgcgtgtt tatgtcgcgg tggtcgagca cggcggcgtt gccggtgcgg
     7321 cgtccgagct gaagctcggc gaagcgcagg tgagcgaccg gatcgactgc ctcgaacggt
     7381 atctcgactg ccgcctgctg cagtgccgcg agcgcggcta cgtcgcctgc accgacacgg
     7441 gcgtcgcatt ccacgtgtgc tgccggcgta cgctgtccgc ggtcgagcag gcgaccggcg
     7501 cggcgctcac gcgaaagacc gacgcgcggg attgtgcaga cgacaccgcg cattgccctg
     7561 atttcccgcc gccgagtgcc gctcacgcat cctcacaccg accgtcacct tgatcttcgc
     7621 caggcgagcg catccgccgc cgcttcggtc atttcctgct cgcagccgat ggccgggctg
     7681 atcgtgatcg gcctgcgacc gcgatgacgc aggcagcgtc tcaggtcacg acgatggtct
     7741 cggtccggtg ctgatggaca tgcttgccac gtacgccgcc agggctggcc gatcgagctt
     7801 cgcccgtcga cgggccggat cgtgcgtcgt gatgctcgat cgctgcgctg catccactac
     7861 cgaatgacgg tgttcgatca tctgattgct gcttcgatat cgagtcattc gtttccgcct
     7921 tcctgctcat ctcgatgtcg tctgccgcta tggatttcga ctcgagaatt tccacgagag
     7981 gctggccggt ccccgtgagg gcggatatca aaaatcgttc acatcagtcg tgaaaatcca
     8041 tcgttggacg ttggcgacat ggaatccaat acttccatca tgtcgacgcg atgaatctcc
     8101 cgctcgacac gaggttgcga tccgcacgtt ccgacagtcc atcatgttgt gttttgggtc
     8161 taacgcatca ggtggtggca atcgggcgct tcgacattgc aacatacgtt caacttgaaa
     8221 gtgcacggta caacatgagc cacaacgtcg actacaacga aatttcgatc aagacacctg
     8281 aagagatcgc gatgctgcgt gccgcagggc gcatcgcagc acaggtcctg caggatctca
     8341 cccctcacat ccagcctggc gtgacatcgc gtcagatcaa cgacatcgct tacgacctga
     8401 tcgtcaacaa gtaccacgcg gaaatcgatc gggaagatct ctccggctac gactcgagcg
     8461 agtacgcctg catttcgatc gcgcacaacg agaacgcctt cagcggcgaa ccgaacgacc
     8521 tgcccttgaa aaaaggcgat cttttcggcg tcgacgtcag catcaagaag gaaggatggt
     8581 gcggcgacac tcagcgcatg tggatcgtgg gcgaggaaac aagcgccgag gcgcgtttgc
     8641 tgatggcggt cggatatcag gccatgtgtc tcggcatcag tctggttcgt ccgggcgcgg
     8701 cggtgcagga tattgcgcgt cgcgtccagg cctacgtcga atcgttcggg ttttcgatgc
     8761 tgcgcgttcc cagcggaacg gggcattcga tcggtcaggt tcacgcggac ggatggctga
     8821 taccgtacta cgagtcgtcc gtgaacgaag ggcgcgtgct ggaaaaaggc atggtcatca
     8881 cggtcgagcc gttcatctgc gccgggtccg gcgagggtat ccgtttgaac aacgtcacgc
     8941 gttcggcgca gaccgcggac aagtcgcttg ccgtctactg ggagcacgtg gtcgcggtca
     9001 cggagtcggg ctgcgaggtg ctcgatctgc gcgacggcga ggacgttacg ttctacgacg
     9061 ctcgtcctcg cggctaaggc acgacggttt tgtcttgcgc aagcgagtcc cggtctttct
     9121 gttggaccat ttcctccagc caggccacga actgcaggat ggcgtcctgt ttgggatcgc
     9181 cttcccgcca gcacagatag taggcaaggt tggagggaat tcgggtgctc ccgacctgta
     9241 ccagttttcc ctcctgcagg taagagcgta tcaaccgttc tctcagcatg gcgacacctt
     9301 gccccgcgag tgcggcctgg agcagggatg ccgcatcgtt gaacatgggg ccgtactccg
     9361 ggtcgcccgc aacgagattg gcggcatgaa agaactcgcg ccacgaccgg ccggagaaac
     9421 gtagcagcgg aacgcgagcc agatccgtga cggtcagcgg ccggtgcttg tcgagaaacg
     9481 cgggcgtgca tgccgcaatc acctggtcgt ccagcagttt ccttgactgg aatccgtttc
     9541 gatcgatgct tttatgccag atgccgatat ccgattcgtg tccttcggga acgtcgagcg
     9601 tattgcgaac cgcgatcgag agatcgagat gcgggtatcg gctgtaaaac acgtcgagct
     9661 ccggaatcag ccatgcggtc gcgaagtcgg ccatgacgct gaccttgaga acgaggcgct
     9721 gttgtctatc cgcatccctt gcttccagaa gcgcgcattc gatgtcggcc agtccctgac
     9781 gcacgcgctc ggccagatgc gtacacgcgg gcgttggaat catctgcgac tgcgtacgcg
     9841 tgaacaacga tattcccagc atcgattcga tctgccggat ctggtgactg atcgcgctat
     9901 gcgtgagact gagctcgttg gcggccgcag taaagcttcg gcttcgttcg gccgtttcga
     9961 gtgcgcgcag cgcagaaaaa ttgaatcgaa tccggtcggt catctcgagg gcgggggcgt
    10021 gagttacggg atgatcggcg gatggtaggc gagggtaccc gcaagggccc agagcatgaa
    10081 gatcaccagc ggaagatgga cgaccagttg cgtgaacgtg aatccgacga tgtcacgcgc
    10141 acgcagcccg agcacgccga gcagaggcag catccagaat ggattgatca ggttcggcaa
    10201 tgcctccgcc gcgttgtaca ccgttaccgc ccagcccaga tgcacttgca gcagtttcgc
    10261 ggcctcgatc acgtacggcg cctcgatgat ccatttgccg ccgccggacg gcacgaagaa
    10321 tccgaggacg gccgagtaca cgcccatgac ggcgggaaat gacgagtgcg aggacagtgc
    10381 gacgaagaaa tgcgcgaggt gatcggacag cgtcaatccg gcgggcgccg acgccttcgt
    10441 caggatgtag gcgatgccgc cgtacaacgg aaactggatc agcacccctg caaccgacgg
    10501 taccgcacgc gcgacggcat tgaggaatcg ccgcggccgc cagttcagca acatcccgag
    10561 catcaggaac aagtagttgt aggtgttcag attcgagatc gcgatcatcg ggtttttcgt
    10621 cgtgaactcg tgccacgccc agattgcacc gatcgccacg atgacgatcg tgatgagagg
    10681 gctgtattcg agccagtctc ccgggcgcga cgggcgcgcg atcgttgcat gggcttcgtc
    10741 gagctgaatc ccaaactccg ccgcggtctt cgcacgtgcg tcgccggggg cggacagata
    10801 agcgatcgct agcgat
//
