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Overview
1.1
1.2
1.3
1.4
1.5

### Identified secondary metabolite regions using strictness 'relaxed'

NC_013037.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1 | arylpolyene | 2,410,428 | 2,455,879 | flexirubin | Polyketide | 27%
Region 2 | T3PKS,terpene | 2,461,840 | 2,503,810 | carotenoid | Terpene | 28%
Region 3 | RiPP-like | 5,929,283 | 5,941,499 |
Region 4 | RRE-containing | 6,079,175 | 6,099,441 |
Region 5 | resorcinol,arylpolyene | 6,938,406 | 6,967,790 | flexirubin | Polyketide | 13%

NC_013037.1 - Region 1 - arylpolyene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,410,428 - 2,455,879 nt. (total: 45,452 nt) Show pHMM detection rules used
arylpolyene: (APE_KS1 or APE_KS2)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | arylpolyene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000231.1 |  | 0.24 | Polyketide | griseusin | Streptomyces griseus
BGC0000248.1 |  | 0.21 | Polyketide | naphtocyclinone | Streptomyces arenae
BGC0000272.1 |  | 0.21 | Polyketide | spore pigment | Streptomyces collinus
BGC0000194.1 |  | 0.20 | Polyketide | actinorhodin | Streptomyces coelicolor A3(2)
BGC0000219.1 |  | 0.20 | Polyketide, Saccharide | elloramycin | Streptomyces olivaceus
BGC0000261.1 |  | 0.20 | Polyketide | R1128 | Streptomyces sp. R1128
BGC0000221.1 |  | 0.20 | Polyketide | erdacin | uncultured soil bacterium V167
BGC0000237.1 |  | 0.19 | Polyketide | lactonamycin Z | Streptomyces sanglieri
BGC0002000.1 |  | 0.19 | Polyketide | setomimycin | Streptomyces aurantiacus JA 4570
BGC0000275.1 |  | 0.18 | Polyketide | tetracenomycin C | Streptomyces glaucescens

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000231.1 |  | 0.57 | Polyketide | griseusin | Streptomyces griseus
BGC0000248.1 |  | 0.54 | Polyketide | naphtocyclinone | Streptomyces arenae
BGC0000272.1 |  | 0.54 | Polyketide | spore pigment | Streptomyces collinus
BGC0000194.1 |  | 0.53 | Polyketide | actinorhodin | Streptomyces coelicolor A3(2)
BGC0000219.1 |  | 0.53 | Polyketide, Saccharide | elloramycin | Streptomyces olivaceus
BGC0000261.1 |  | 0.53 | Polyketide | R1128 | Streptomyces sp. R1128
BGC0000221.1 |  | 0.52 | Polyketide | erdacin | uncultured soil bacterium V167
BGC0000237.1 |  | 0.51 | Polyketide | lactonamycin Z | Streptomyces sanglieri
BGC0002000.1 |  | 0.51 | Polyketide | setomimycin | Streptomyces aurantiacus JA 4570
BGC0000275.1 |  | 0.50 | Polyketide | tetracenomycin C | Streptomyces glaucescens

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_013037.1 - Region 2 - T3PKS,terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,461,840 - 2,503,810 nt. (total: 41,971 nt) Show pHMM detection rules used
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)
terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T3PKS | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001938.1 |  |  | 0.67 | Polyketide | entotheonella | Candidatus Entotheonella serta
BGC0001962.1 |  |  | 0.66 | Polyketide | hierridin B, hierridin C | Cyanobium sp. LEGE 06113
BGC0000648.1 |  |  | 0.64 | Terpene | carotenoid | Myxococcus xanthus
BGC0001905.1 |  |  | 0.63 | Polyketide | violapyrone B | Streptomyces somaliensis
BGC0000647.1 |  |  | 0.62 | Terpene | carotenoid | Rhodobacter sphaeroides
BGC0000645.1 |  |  | 0.59 | Terpene | carotenoid | Halobacillus halophilus DSM 2266
BGC0000650.1 |  |  | 0.58 | Terpene | carotenoid | Algoriphagus sp. KK10202C
BGC0000630.1 |  |  | 0.49 | Terpene | (2R,3S,3'S)-2-hydroxyastaxanthin | Paracoccus haeundaensis
BGC0000656.1 |  |  | 0.47 | Terpene | zeaxanthin | Xanthobacter autotrophicus Py2
BGC0001831.1 |  |  | 0.46 | Polyketide | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001938.1 |  | 0.67 | Polyketide | entotheonella | Candidatus Entotheonella serta
BGC0001962.1 |  | 0.66 | Polyketide | hierridin B, hierridin C | Cyanobium sp. LEGE 06113
BGC0000648.1 |  | 0.65 | Terpene | carotenoid | Myxococcus xanthus
BGC0001905.1 |  | 0.65 | Polyketide | violapyrone B | Streptomyces somaliensis
BGC0000645.1 |  | 0.64 | Terpene | carotenoid | Halobacillus halophilus DSM 2266
BGC0000647.1 |  | 0.64 | Terpene | carotenoid | Rhodobacter sphaeroides
BGC0000650.1 |  | 0.63 | Terpene | carotenoid | Algoriphagus sp. KK10202C
BGC0000630.1 |  | 0.58 | Terpene | (2R,3S,3'S)-2-hydroxyastaxanthin | Paracoccus haeundaensis
BGC0000656.1 |  | 0.57 | Terpene | zeaxanthin | Xanthobacter autotrophicus Py2
BGC0001831.1 |  | 0.56 | Polyketide | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_013037.1 - Region 3 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 5,929,283 - 5,941,499 nt. (total: 12,217 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000554.1 |  | 0.20 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001861.1 |  | 0.20 | RiPP | bacillicin BAG2O | Bacillus cereus BAG2O-1
BGC0000617.1 |  | 0.19 | RiPP | coagulin | Bacillus coagulans
BGC0000500.1 |  | 0.19 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000624.1 |  | 0.16 | RiPP | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius
BGC0001210.1 |  | 0.15 | RiPP | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0001928.1 |  | 0.15 | Other | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0000626.1 |  | 0.15 | RiPP | thuricin | Bacillus thuringiensis
BGC0001551.1 |  | 0.15 | RiPP | citrulassin E | Streptomyces glaucescens
BGC0001639.1 |  | 0.15 | RiPP | klebsidin | Klebsiella pneumoniae

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000554.1 |  | 0.53 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001861.1 |  | 0.53 | RiPP | bacillicin BAG2O | Bacillus cereus BAG2O-1
BGC0000617.1 |  | 0.51 | RiPP | coagulin | Bacillus coagulans
BGC0000500.1 |  | 0.51 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000624.1 |  | 0.47 | RiPP | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius
BGC0001210.1 |  | 0.46 | RiPP | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0001928.1 |  | 0.46 | Other | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0000626.1 |  | 0.45 | RiPP | thuricin | Bacillus thuringiensis
BGC0001551.1 |  | 0.45 | RiPP | citrulassin E | Streptomyces glaucescens
BGC0001639.1 |  | 0.45 | RiPP | klebsidin | Klebsiella pneumoniae

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_013037.1 - Region 4 - RRE-containing
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 6,079,175 - 6,099,441 nt. (total: 20,267 nt) Show pHMM detection rules used
RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RRE-containing | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001639.1 |  | 0.22 | RiPP | klebsidin | Klebsiella pneumoniae
BGC0001634.1 |  | 0.20 | RiPP | keywimysin | Streptomyces sp. NRRL F-5702
BGC0001550.1 |  | 0.19 | RiPP | citrulassin D | Streptomyces katrae
BGC0000575.1 |  | 0.19 | RiPP | lariatin | Rhodococcus jostii
BGC0001889.1 |  | 0.17 | RiPP | fusilassin | Thermobifida fusca YX
BGC0001496.1 |  | 0.17 | RiPP | actinokineosin | Actinokineospora spheciospongiae
BGC0001645.1 |  | 0.17 | RiPP | lagmysin | Streptomyces sp. NRRL S-118
BGC0000571.1 |  | 0.16 | RiPP | burhizin | Paraburkholderia rhizoxinica HKI 454
BGC0000554.1 |  | 0.16 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000504.1 |  | 0.16 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001639.1 |  | 0.55 | RiPP | klebsidin | Klebsiella pneumoniae
BGC0001634.1 |  | 0.52 | RiPP | keywimysin | Streptomyces sp. NRRL F-5702
BGC0001550.1 |  | 0.51 | RiPP | citrulassin D | Streptomyces katrae
BGC0000575.1 |  | 0.51 | RiPP | lariatin | Rhodococcus jostii
BGC0001889.1 |  | 0.49 | RiPP | fusilassin | Thermobifida fusca YX
BGC0001496.1 |  | 0.48 | RiPP | actinokineosin | Actinokineospora spheciospongiae
BGC0001645.1 |  | 0.48 | RiPP | lagmysin | Streptomyces sp. NRRL S-118
BGC0000571.1 |  | 0.47 | RiPP | burhizin | Paraburkholderia rhizoxinica HKI 454
BGC0000554.1 |  | 0.47 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000504.1 |  | 0.46 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_013037.1 - Region 5 - arylpolyene,resorcinol
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 6,938,406 - 6,967,790 nt. (total: 29,385 nt) Show pHMM detection rules used
Region on contig edge.
resorcinol: DarB
arylpolyene: (APE_KS1 or APE_KS2)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | resorcinol | arylpolyene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001526.1 |  |  | 0.48 | Other | bartolosides E, bartolosides F, bartolosides G, bartolosides H, bartolosides I, bartolosides J, bartolosides K | Synechocystis salina LEGE 06099
BGC0001525.1 |  |  | 0.45 | Other | bartoloside 2, bartoloside 3, bartoloside 4 | Synechocystis salina LEGE 06155
BGC0000836.1 |  |  | 0.45 | Other | APE Ec | Escherichia coli CFT073
BGC0000272.1 |  |  | 0.41 | Polyketide | spore pigment | Streptomyces collinus
BGC0000248.1 |  |  | 0.41 | Polyketide | naphtocyclinone | Streptomyces arenae
BGC0000231.1 |  |  | 0.38 | Polyketide | griseusin | Streptomyces griseus
BGC0001897.1 |  |  | 0.38 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10
BGC0001927.1 |  |  | 0.37 | Other | A-94964 | Streptomyces sp.
BGC0001197.1 |  |  | 0.37 | Polyketide | frankiamicin | Frankia sp. EAN1pec
BGC0000234.1 |  |  | 0.36 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001526.1 |  | 0.57 | Other | bartolosides E, bartolosides F, bartolosides G, bartolosides H, bartolosides I, bartolosides J, bartolosides K | Synechocystis salina LEGE 06099
BGC0000836.1 |  | 0.57 | Other | APE Ec | Escherichia coli CFT073
BGC0001525.1 |  | 0.56 | Other | bartoloside 2, bartoloside 3, bartoloside 4 | Synechocystis salina LEGE 06155
BGC0000272.1 |  | 0.53 | Polyketide | spore pigment | Streptomyces collinus
BGC0000248.1 |  | 0.53 | Polyketide | naphtocyclinone | Streptomyces arenae
BGC0001927.1 |  | 0.52 | Other | A-94964 | Streptomyces sp.
BGC0000231.1 |  | 0.51 | Polyketide | griseusin | Streptomyces griseus
BGC0001897.1 |  | 0.51 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10
BGC0001197.1 |  | 0.50 | Polyketide | frankiamicin | Frankia sp. EAN1pec
BGC0000234.1 |  | 0.50 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names