LOCUS       c00003_NZ_RKHR..       12499 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_RKHR01000005.1 Sinobacterium caligoides strain DSM 100316
            Ga0244720_103, whole genome shotgun sequence.
ACCESSION   NZ_RKHR01000005
VERSION     NZ_RKHR01000005
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 15:13:06
            Original ID  :: NZ_RKHR01000005.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 416556
            Orig. end    :: 429055
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12499
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[421556:424055](+)"
                     /cutoff="20000"
                     /detection_rule="IucA_IucC"
                     /neighbourhood="5000"
                     /product="siderophore"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..7499
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="IucA_IucC"
                     /neighbourhood="5000"
                     /product="siderophore"
                     /protocluster_number="1"
     cand_cluster    1..12499
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="IucA_IucC"
                     /kind="single"
                     /product="siderophore"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12499
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="siderophore"
                     /region_number="1"
                     /rules="IucA_IucC"
                     /tool="antismash"
     CDS             628..2340
                     /NRPS_PKS="Domain: Beta_elim_lyase (164-302). E-value:
                     5.5e-07. Score: 20.9. Matches aSDomain:
                     nrpspksdomains_ctg3_332_Beta_elim_lyase.1"
                     /NRPS_PKS="type: other"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1180:Decarboxylase, pyridoxal-dependent (Score: 377.3;
                     E-value: 1.6e-114)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg3_332"
                     /transl_table=11
                     /translation="MGSTIEAMDTETEFLSEKQAKQRPSAKEFVFNEHQLSAYEEAMQQ
                     GISLVQKTIAGKEKPFTGILPHELAAKFSDIDLSSPLDSINDALAEVDDLYLQDAVYFH
                     HPKYVAHLNCPVAYPAILAELILSSINSSVDTWDQSAGATLIEQKLIDWSCFQIGLGDE
                     ADGIFTSGGTQSNLMALLLARDHFCSKHFPEYDIKHGGLPASAQRIRIFTSSVSHFSVQ
                     KAAAILGLGYDAVISIDCDQHFTMDSEALEQAINQAKADGLLPMAVIATAGTTDFGSID
                     PLHSIADLCDEHDLWMHTDAAYGCGLLASKNQRHLLSGIERSQSVTVDFHKSFLQPVSC
                     SALLTRNKKNLGVVTHHAEYLNPLSAREQGTPNLVDKSLQTTRRFDALKLWLTLRTAGI
                     DAIGEIFDKVCETAASCYLRMLLSPSFEPMHLPQMSTLVFRYIPSSPSLTAQHTEQDID
                     DTNAHIREALFRSGQAVVAGTKIGARRYLKITLLNPETTLNDIDEILTMIKQLGDEYLQ
                     SIPQTNSDIIASNKATDTVTIITDNLGNRANEQEKNAPINDHNTSINSQEACR"
     PFAM_domain     874..1950
                     /aSDomain="Pyridoxal_deC"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00282.21"
                     /description="Pyridoxal-dependent decarboxylase conserved
                     domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_332_0001"
                     /evalue="3.10E-64"
                     /label="ctg3_332"
                     /locus_tag="ctg3_332"
                     /protein_end="441"
                     /protein_start="82"
                     /score="217.1"
                     /tool="antismash"
                     /translation="DSINDALAEVDDLYLQDAVYFHHPKYVAHLNCPVAYPAILAELIL
                     SSINSSVDTWDQSAGATLIEQKLIDWSCFQIGLGDEADGIFTSGGTQSNLMALLLARDH
                     FCSKHFPEYDIKHGGLPASAQRIRIFTSSVSHFSVQKAAAILGLGYDAVISIDCDQHFT
                     MDSEALEQAINQAKADGLLPMAVIATAGTTDFGSIDPLHSIADLCDEHDLWMHTDAAYG
                     CGLLASKNQRHLLSGIERSQSVTVDFHKSFLQPVSCSALLTRNKKNLGVVTHHAEYLNP
                     LSAREQGTPNLVDKSLQTTRRFDALKLWLTLRTAGIDAIGEIFDKVCETAASCYLRMLL
                     SPSFEPMHLPQMSTLVFRY"
     aSDomain        1120..1533
                     /aSDomain="Beta_elim_lyase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg3_332_Beta_elim_lyase.1"
                     /evalue="5.50E-07"
                     /label="ctg3_332_Beta_elim_lyase.1"
                     /locus_tag="ctg3_332"
                     /protein_end="302"
                     /protein_start="164"
                     /score="20.9"
                     /tool="antismash"
                     /translation="DGIFTSGGTQSNLMALLLARDHFCSKHFPEYDIKHGGLPASAQRI
                     RIFTSSVSHFSVQKAAAILGLGYDAVISIDCDQHFTMDSEALEQAINQAKADGLLPMAV
                     IATAGTTDFGSIDPLHSIADLCDEHDLWMHTDAA"
     CDS             2340..3704
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1080:lysine/ornithine N-monooxygenase (Score: 400.5;
                     E-value: 1.2e-121)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg3_333"
                     /transl_table=11
                     /translation="MSPVIYDFVAIGLGPFNLSLACLSSPIEGLNGLFLEQKEEFNWHP
                     GLMFESAHLQTPFMSDLVTLADPTHPLSFLNYIKKQGRLYSFYIREDFYIMRREYNQYC
                     RWAANELDNIAFGQCVTEVTRSEKTDCYRLVVRNTKDNSERIVYSRKLVLGTGPSPYRP
                     DCCPDSDKRICHASDYLYQKEQLQQQSSITLVGSGQSAAEIYYDLLGDIDQYGYELNWI
                     TRAPRFFPLEYTKLTLEMTSPEYVDYFYALPQQKKDELINRQKQLYKGINGDLINEIFD
                     LLYVKRLQHNFTSNILTNSTLQGVDNPDNTAQPLTLRFMQNEQQQAYELNSQRMILATG
                     YQYQMPDFIAGISQQIRWDDHGRFDVQRNYSIDQKGGEIFVQNAELHSHGFVTPDLGMA
                     CYRNSYILREILGYAPYEVEERIAFQQFTAPTKTGGNIRAVEPIPLRQESASTCR"
     PFAM_domain     2352..3365
                     /aSDomain="K_oxygenase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13434.8"
                     /description="L-lysine 6-monooxygenase (NADPH-requiring)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_333_0002"
                     /evalue="1.80E-118"
                     /label="ctg3_333"
                     /locus_tag="ctg3_333"
                     /protein_end="342"
                     /protein_start="4"
                     /score="395.6"
                     /tool="antismash"
                     /translation="IYDFVAIGLGPFNLSLACLSSPIEGLNGLFLEQKEEFNWHPGLMF
                     ESAHLQTPFMSDLVTLADPTHPLSFLNYIKKQGRLYSFYIREDFYIMRREYNQYCRWAA
                     NELDNIAFGQCVTEVTRSEKTDCYRLVVRNTKDNSERIVYSRKLVLGTGPSPYRPDCCP
                     DSDKRICHASDYLYQKEQLQQQSSITLVGSGQSAAEIYYDLLGDIDQYGYELNWITRAP
                     RFFPLEYTKLTLEMTSPEYVDYFYALPQQKKDELINRQKQLYKGINGDLINEIFDLLYV
                     KRLQHNFTSNILTNSTLQGVDNPDNTAQPLTLRFMQNEQQQAYELNSQRMILATGYQ"
     CDS             3695..4921
                     /locus_tag="ctg3_334"
                     /transl_table=11
                     /translation="MSLKHSLILLTLISVVADTMLLPFYPQFFQQAFAVDNPEHVGFYI
                     AACCFTVMTALPLWAKVARHVHELHLWVYTQVAAACLGLFCYQTESLVAFWIASQLMLV
                     FKASYLLIYPFVMRLEEKEQHLKVVGLFSVLMHFGAIGGAILGGFALQFYQPQDIYLIM
                     VGSDITQVLLCLYLIRLLATPWRAHAQPAEATENGSSRSWQRSIVFRLSVVSMLFYFSA
                     FLIRPFFVSYWQSISQLNSELYSAIAYSIPAWVALYCLWLSHRRPSSQSHFAAICVGGA
                     CAIAGLFLQGSGEAWWVAGGRLLFGYAMYQITVRLEVLLFENSDPERYGDDFSKVHFFQ
                     NLGVIFASFSVGYIVDSYGPASTFTIALVGFTIATICFFLFFRTLLRTPSTKTTTSPNN
                     AHTSGELTS"
     PFAM_domain     3713..4621
                     /aSDomain="MFS_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07690.18"
                     /description="Major Facilitator Superfamily"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_334_0003"
                     /evalue="2.00E-09"
                     /label="ctg3_334"
                     /locus_tag="ctg3_334"
                     /protein_end="309"
                     /protein_start="6"
                     /score="36.9"
                     /tool="antismash"
                     /translation="LILLTLISVVADTMLLPFYPQFFQQAFAVDNPEHVGFYIAACCFT
                     VMTALPLWAKVARHVHELHLWVYTQVAAACLGLFCYQTESLVAFWIASQLMLVFKASYL
                     LIYPFVMRLEEKEQHLKVVGLFSVLMHFGAIGGAILGGFALQFYQPQDIYLIMVGSDIT
                     QVLLCLYLIRLLATPWRAHAQPAEATENGSSRSWQRSIVFRLSVVSMLFYFSAFLIRPF
                     FVSYWQSISQLNSELYSAIAYSIPAWVALYCLWLSHRRPSSQSHFAAICVGGACAIAGL
                     FLQGSGEAWWVAGGRLLFGYAM"
     CDS             5001..7499
                     /gene_functions="biosynthetic (rule-based-clusters)
                     siderophore: IucA_IucC"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1203:putative siderophore biosynthesis protein (Score:
                     123.8; E-value: 1.9e-37)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg3_335"
                     /sec_met_domain="IucA_IucC (E-value: 1.1e-81, bitscore:
                     268.8, seeds: 168, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAAPLKEPMNHTTFFDRHSDEHGRLSLIPFCPDSHSAILHRWVS
                     QPYAAFWGMLDKTEAEVKEEYYKLCDTPRTRVYLGLHNDRPAFLVETYAVEDSPLARHY
                     SVQSGDIGMHILLAPPRHPIPHFSHAVLSAVMDFIFEHPDNLRVVVEPDHRNDKIHRLN
                     KRVGFFHQQRVQLADKETYLAFCTREQFAMAKAREDRVNEPHTLPHYDPYRSTCGNALT
                     TAPGIASESIDSETWAKVNRQLVQKALSELCHERILDPRCVDTTALWCNYRLSTDSGDV
                     EYRFTAQRLPLNHWQIDLYSIERMESGRSHELDAIDFIVDFQGSLGIDSSRLASYLEEV
                     TSTLCSSAYKQQRPWQSAKYLACADFQSVETGMTEGHPCFIANNGRIGFSAADFRAYAP
                     EAAAPVTLMWLAAHKQRAHFSVGPDLDYQQLLSEELDLSTRNRFTQTLVERGVEPDDYL
                     WIPIHPWQWLNKLSNIYAPEIASNHLILLGYGDDAYLAQQSIRTFYNISQPNKRYVKTA
                     LSILNMGFMRGLSAYYMRSTPAINQWLRELIDNDAYLQSKGFDMLREIAAVGYEIPHYD
                     KQRIGDNPYRKMLAALWRENPHSRLKPDQRLMTMASLLHVDPAGEALLPALIEASGLSI
                     DDWLARYFDVYLTPLLHCFYQHELAFMPHGENLILVFDNNIPVRAIMKDIGEEIVLQNS
                     RQPLPEDVERIKVDVPEEMEVLAIFTDVFDCFFRFMSATLYQHADYPVEDFWRGVGHCI
                     RDYQHDNPQLAARFEQHDLFADEFALSCLNRLQLRNNQQMVDLTDPANSLCFAGTLNNP
                     VAPYRPSLQLDSDHLRSREE"
     PFAM_domain     5097..5528
                     /aSDomain="Acetyltransf_8"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13523.8"
                     /description="Acetyltransferase (GNAT) domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_335_0004"
                     /evalue="1.70E-43"
                     /label="ctg3_335"
                     /locus_tag="ctg3_335"
                     /protein_end="176"
                     /protein_start="32"
                     /score="147.8"
                     /tool="antismash"
                     /translation="PDSHSAILHRWVSQPYAAFWGMLDKTEAEVKEEYYKLCDTPRTRV
                     YLGLHNDRPAFLVETYAVEDSPLARHYSVQSGDIGMHILLAPPRHPIPHFSHAVLSAVM
                     DFIFEHPDNLRVVVEPDHRNDKIHRLNKRVGFFHQQRVQL"
     PFAM_domain     6093..6845
                     /aSDomain="IucA_IucC"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04183.14"
                     /description="IucA / IucC family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_335_0005"
                     /evalue="7.10E-80"
                     /label="ctg3_335"
                     /locus_tag="ctg3_335"
                     /protein_end="615"
                     /protein_start="364"
                     /score="268.1"
                     /tool="antismash"
                     /translation="DFQSVETGMTEGHPCFIANNGRIGFSAADFRAYAPEAAAPVTLMW
                     LAAHKQRAHFSVGPDLDYQQLLSEELDLSTRNRFTQTLVERGVEPDDYLWIPIHPWQWL
                     NKLSNIYAPEIASNHLILLGYGDDAYLAQQSIRTFYNISQPNKRYVKTALSILNMGFMR
                     GLSAYYMRSTPAINQWLRELIDNDAYLQSKGFDMLREIAAVGYEIPHYDKQRIGDNPYR
                     KMLAALWRENPHSRLKPDQRLMTMASLLH"
     PFAM_domain     6909..7379
                     /aSDomain="FhuF"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF06276.14"
                     /description="Ferric iron reductase FhuF-like transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_335_0006"
                     /evalue="1.50E-41"
                     /label="ctg3_335"
                     /locus_tag="ctg3_335"
                     /protein_end="793"
                     /protein_start="636"
                     /score="142.6"
                     /tool="antismash"
                     /translation="DWLARYFDVYLTPLLHCFYQHELAFMPHGENLILVFDNNIPVRAI
                     MKDIGEEIVLQNSRQPLPEDVERIKVDVPEEMEVLAIFTDVFDCFFRFMSATLYQHADY
                     PVEDFWRGVGHCIRDYQHDNPQLAARFEQHDLFADEFALSCLNRLQLRNNQQM"
     CDS             7563..8669
                     /locus_tag="ctg3_336"
                     /transl_table=11
                     /translation="MSGELAPRPPRLMAVDLGRGLAVFLMILVHTLWMYADQATQSASW
                     LGHVIHFIGKGTPAFLLCMGISMLTSQQQSALATLRKGLLILCFGYLMNGLKFLVPIAL
                     GIMPENFIQAYGWAHPLNASQWRYLLLTGDILQMAGLSLILLAAVRQYLHNKYTVLVVA
                     LAILAISRELSGYTPQIAGLDYLAKLFFSNSFHVYFPLFPWMSFILFGMFIGMLIRDNN
                     WNYCTIFNRLPVPALACICIGGSLCYWRFDYHFGNFFHLGPGGVIYLLGINFALMWLIH
                     KVTESGVNNRAVDFLNFCSQRVTSMYVIQWTLICWGMSVIGFQSLSLMQTLAIMPVIVV
                     LTVLVQQSKDYLVNSLQQLSSQKTSLKH"
     PFAM_domain     7593..8282
                     /aSDomain="HGSNAT_cat"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07786.14"
                     /description="Heparan-alpha-glucosaminide
                     N-acetyltransferase, catalytic"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_336_0007"
                     /evalue="7.70E-30"
                     /label="ctg3_336"
                     /locus_tag="ctg3_336"
                     /protein_end="240"
                     /protein_start="10"
                     /score="104.2"
                     /tool="antismash"
                     /translation="RLMAVDLGRGLAVFLMILVHTLWMYADQATQSASWLGHVIHFIGK
                     GTPAFLLCMGISMLTSQQQSALATLRKGLLILCFGYLMNGLKFLVPIALGIMPENFIQA
                     YGWAHPLNASQWRYLLLTGDILQMAGLSLILLAAVRQYLHNKYTVLVVALAILAISREL
                     SGYTPQIAGLDYLAKLFFSNSFHVYFPLFPWMSFILFGMFIGMLIRDNNWNYCTIFNRL
                     PVPALACI"
     CDS             complement(8666..9169)
                     /locus_tag="ctg3_337"
                     /transl_table=11
                     /translation="MNKLAVKVREAASEDCLAIAKQRIDSWCHAHQSIIDEDILLGLDL
                     EARVIAWEKALGPPGKLIVSTVDNNITGFVYVRFHDNSESVGEVVALYLQLKWVGAGHA
                     GELMRAAKSYLHRKRSDPVFVLTLENRAKENEIYDAVTIRRDSRRKIIAAGGLLESDYR
                     KYLH"
     CDS             9877..11160
                     /locus_tag="ctg3_338"
                     /transl_table=11
                     /translation="MSLKMKALPFAITAATVSLSSYGAGFQVSEQSASGLGRAFAGEAA
                     VADNAAVIARNPAAMTRFKRAEVSGAITVIDADIDVDSTDGNGRHQTAHDIAPTQAVPA
                     AYFVQPINDKLAFGLGLFSNYGVTSDYDESFAPGTAAGKTSLITLNLNPSLAYKVNDQL
                     SVGGGISLVYADAELIRRYGADANWFPTHPAPSDKTIELAGDTYSWGWNVGGLYEFDEN
                     NRFGLSYRAQVDLNFEGDFTDYTGQVVPGLPSPGGQKVDGELDIVLPATAEFSGFHQLN
                     DRVSVQYSILWTDWSAFKEIKATSSDCSYHGQSGVCLAKDEDFEDSMRYAVGASYLLNP
                     QWTLRAGLAYDEKGGQPTLSIPDSNRYWYTAGATYHYSDSLSFDAGLAYVQSEEASFTE
                     GGTLLDDDYALKSNGDAYLASLQVNYKL"
     PFAM_domain     9925..11154
                     /aSDomain="Toluene_X"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03349.18"
                     /description="Outer membrane protein transport protein
                     (OMPP1/FadL/TodX)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_338_0008"
                     /evalue="3.70E-126"
                     /label="ctg3_338"
                     /locus_tag="ctg3_338"
                     /protein_end="426"
                     /protein_start="16"
                     /score="421.2"
                     /tool="antismash"
                     /translation="VSLSSYGAGFQVSEQSASGLGRAFAGEAAVADNAAVIARNPAAMT
                     RFKRAEVSGAITVIDADIDVDSTDGNGRHQTAHDIAPTQAVPAAYFVQPINDKLAFGLG
                     LFSNYGVTSDYDESFAPGTAAGKTSLITLNLNPSLAYKVNDQLSVGGGISLVYADAELI
                     RRYGADANWFPTHPAPSDKTIELAGDTYSWGWNVGGLYEFDENNRFGLSYRAQVDLNFE
                     GDFTDYTGQVVPGLPSPGGQKVDGELDIVLPATAEFSGFHQLNDRVSVQYSILWTDWSA
                     FKEIKATSSDCSYHGQSGVCLAKDEDFEDSMRYAVGASYLLNPQWTLRAGLAYDEKGGQ
                     PTLSIPDSNRYWYTAGATYHYSDSLSFDAGLAYVQSEEASFTEGGTLLDDDYALKSNGD
                     AYLASLQVNYK"
ORIGIN
        1 gtggtgccgc cgcaattacg gcagtgatag cgctactgag agcgctaagc aaaaatttcg
       61 gctttgttct ttgcatcttt ttatccttca acatcctggt aaatacttcg aacgccataa
      121 tacctaaacg agaatgatta tcaacagcat tttaattagc attctgtata agatgtaatg
      181 attctataat gatatttctc ttttgactaa cgtaaattta atttgttaac caagaagaca
      241 actttaaaca aggataaaaa aacaccaaaa aaaacattct aggctacgag aaaaaaaccc
      301 ttacccattg atttaacgat atttaatagc tcacaaaaag acagcaagaa attaaatcaa
      361 caaggcgcca tagagataaa taatcgctat aagcctaatt attttatggt tattaatcgt
      421 tgtaataaaa aaataataat ttaattaaaa ctatcgatta tcgctcacct ctaacatatt
      481 cacccattat cgctattgca aatgggaatc gttctcatta ctatcctctg ccttaacaga
      541 tcctagtggc tcagcgaagc tgcagtatta gccacacaaa accctaaaga aatagggttt
      601 tcatcaaaca atagggagag ttctgctatg ggtagtacaa tcgaagcaat ggatacagag
      661 acagagtttc tgtctgagaa gcaggccaag caacggccta gcgcaaaaga gtttgtcttt
      721 aatgaacacc aactcagcgc ctacgaggag gccatgcaac aaggtatctc gttggtgcaa
      781 aaaaccatcg ccggtaaaga aaaacccttc accggtatcc ttccccacga gctagccgct
      841 aaattttcag acatcgatct tagctcccct ctcgactcaa taaacgatgc actggccgag
      901 gtggatgacc tctacctaca agatgccgtc tattttcatc acccaaaata tgtcgcccac
      961 ctcaactgcc ccgtcgctta tccggctatt cttgccgagc taatactgtc atcgatcaac
     1021 agctcggtcg acacctggga tcaaagcgca ggtgcaacac tcatcgaaca aaagcttatt
     1081 gattggagct gttttcaaat cgggctgggg gatgaagccg acggcatttt tacctcagga
     1141 ggcacacaat ctaatttaat ggcattactg ctagcccgcg accacttctg cagcaaacat
     1201 tttcccgagt acgatatcaa acacggcggc cttcctgcct cagcacaacg tattcgtatt
     1261 ttcacctcaa gcgtcagcca tttcagcgta caaaaagcag ccgcgattct cggcctcgga
     1321 tacgatgcag tcatcagcat cgactgtgat caacacttca ccatggattc ggaagcactc
     1381 gaacaagcca tcaaccaggc aaaagctgat ggtttactgc ccatggccgt gattgccacc
     1441 gccggcacga cagactttgg cagcattgac ccgctacaca gtatcgccga cctctgtgat
     1501 gagcatgact tatggatgca caccgacgcc gcctatggct gcggtttatt ggcctcaaag
     1561 aaccagcgtc acctgctttc ggggatcgag cgctcacaat ctgtcaccgt cgactttcac
     1621 aaatcgtttc tacagcctgt cagctgtagc gccctactga ctcgaaacaa aaaaaatctt
     1681 ggtgtagtga ctcatcacgc cgaatacctt aatccactga gcgcacgcga acagggtacg
     1741 cccaacttgg ttgacaagag tctacaaacc actcgacgtt ttgacgcatt aaagctctgg
     1801 ctcactctgc gcacagccgg tattgatgcc atcggggaaa tcttcgacaa agtgtgcgaa
     1861 acggcagcca gttgttatct acgcatgcta ttaagcccct cttttgagcc catgcacctg
     1921 ccacaaatga gcaccttggt gttccgttac attccctcgt ctccatcgct caccgctcag
     1981 cacaccgagc aggatattga tgacaccaac gcccacatac gcgaagcact attcaggtca
     2041 ggccaggcgg ttgtcgccgg aaccaaaata ggtgcacgcc gctatttaaa aataacgttg
     2101 ttaaacccgg aaaccacgtt gaatgacatc gacgaaattt tgacaatgat taaacagctt
     2161 ggcgatgagt acctgcaatc aatcccacaa accaatagcg acattatcgc cagtaacaag
     2221 gccactgaca cggtaacaat catcacagat aaccttggca accgtgcaaa cgagcaagaa
     2281 aagaacgccc ccataaacga tcacaatact tctatcaact cgcaagaggc ctgccgctaa
     2341 tgtcacccgt tatttatgat tttgtcgcca tcggcctcgg ccccttcaac cttagcttag
     2401 cctgccttag ctcgcccatt gaagggctga acggtttatt tctagaacaa aaagaggaat
     2461 tcaactggca ccctgggcta atgtttgaga gtgcgcattt acagacgccg tttatgtctg
     2521 atttggtaac cttagcagac ccgacccacc ctctcagctt ccttaattac atcaaaaagc
     2581 aggggcgact ttattcattt tatattcgcg aagactttta catcatgcgt cgcgagtaca
     2641 atcaatactg ccgctgggcg gcgaatgagc tggacaatat cgccttcggt caatgtgtca
     2701 ccgaagtgac ccgtagcgaa aaaacagact gctatcgatt ggtcgtacgc aacactaaag
     2761 ataatagcga gcgcatcgtc tacagccgaa aactcgttct cggcactggg ccatccccgt
     2821 atcggccgga ttgctgtcca gacagcgaca agcgtatctg ccatgcctcc gattacctct
     2881 accaaaaaga gcagctacag caacaaagca gcattacgtt ggtcggcagt ggccagagtg
     2941 ccgcggagat ctactacgac cttctcggcg atatcgatca atacggttat gagctgaact
     3001 ggatcacgcg cgcacctcgt ttcttcccct tggagtacac caaactcacg ttggaaatga
     3061 cctcgccaga gtacgttgat tacttctacg ctcttccaca gcaaaagaaa gatgagctca
     3121 tcaaccgaca aaaacagctt tataaaggta ttaatggtga tctcatcaac gagattttcg
     3181 acctgcttta tgtcaagcgg ctgcaacata acttcaccag taatattctc actaactcca
     3241 cgctgcaagg tgtcgacaac cctgacaaca cagcgcaacc gcttactctg cgtttcatgc
     3301 agaatgagca acaacaagcc tacgagctca atagtcagcg aatgattctc gcaaccggct
     3361 atcaatatca aatgcctgac ttcatcgctg gcattagcca acaaatacgc tgggatgacc
     3421 acggtcgctt tgatgttcaa cgcaactaca gcatcgatca aaaaggcggt gaaattttcg
     3481 tgcaaaatgc tgaattacat tcacacggat ttgtcactcc cgatctcggc atggcctgtt
     3541 accgcaacag ttatatcttg cgtgaaatcc ttggttacgc tccctacgag gtcgaagaac
     3601 gcattgcttt tcagcaattc accgcgccga caaaaacggg tggcaacatt cgcgccgtag
     3661 aacctattcc tctgcgtcag gagagcgcta gcacatgtcg ctaaaacata gcctcattct
     3721 actaacgctg atttcggtag tcgcggacac catgctgcta ccgttttatc cgcaattctt
     3781 tcagcaagcc tttgccgtcg acaacccaga gcatgtcggc ttctacatcg ccgcctgctg
     3841 tttcaccgtg atgacggcgc tgccactctg ggccaaggtc gcccggcacg tgcatgagct
     3901 gcacctttgg gtctataccc aagtcgctgc ggcctgccta ggcttattct gttatcaaac
     3961 cgaatccctt gtggcattct ggattgcatc acaactcatg ctggttttca aagccagtta
     4021 cctgttgatc taccccttcg ttatgcgtct agaggagaag gagcaacacc taaaggttgt
     4081 cggcttgttc tctgtactga tgcattttgg tgccatcggc ggtgccatac tgggcggttt
     4141 tgcgctgcag ttttatcagc cccaagacat ctacctgatt atggtaggct ctgacattac
     4201 ccaggtgctg ctgtgcttgt acctgattcg cctgcttgca acaccctggc gagcacacgc
     4261 tcaaccggca gaggctactg agaatggtag cagccgttct tggcaacgca gcatcgtatt
     4321 tcggttatct gtggtatcga tgctgttcta tttcagcgcc tttctgatcc gacctttctt
     4381 tgtcagttat tggcagtcga tcagccaact caatagcgag ctatacagtg ccattgctta
     4441 ctccatcccc gcctgggtgg cgctgtactg tttgtggcta agccatcgac gcccgtcatc
     4501 acaaagccat ttcgccgcca tctgtgtcgg cggcgcctgc gctatcgccg gactgttttt
     4561 acagggctct ggtgaggctt ggtgggtcgc tggcggacgt ctgttattcg gctacgccat
     4621 gtatcagata accgttcgtc ttgaagttct gctgttcgaa aacagtgacc ccgagcgcta
     4681 tggtgatgac ttcagtaaag ttcatttttt ccaaaatctc ggcgtcattt ttgcgtcatt
     4741 cagtgtcggg tatattgtcg atagctacgg gcctgcaagt acgttcacca tcgcccttgt
     4801 tggcttcacc atcgcaacaa tctgcttttt cctgttcttc aggacactgc tcagaacacc
     4861 gtccaccaag acaaccacgt cgccgaataa tgctcacacg agcggagaac tcacctcatg
     4921 acgacgcctt ataaaagcac ttacccccca caccacctag cgaacggaga agtaaatcgc
     4981 tatcaattgg agagatgcca atgactgctg caccccttaa agagccgatg aaccacacta
     5041 ccttcttcga tcgccacagc gatgaacacg gtcgacttag cttgattcct ttttgccccg
     5101 atagccacag cgcgatcttg catcgctggg tcagccagcc ctatgcagcc ttctggggca
     5161 tgctagataa aaccgaagca gaagttaaag aggagtatta caagctctgc gacacgccgc
     5221 gcacccgtgt atatctcggc ctacataacg acagacccgc gtttcttgtc gaaacctatg
     5281 ccgtagaaga tagcccctta gctcgccact actcggtaca aagcggggat attggcatgc
     5341 atattttgct tgccccaccg cgtcatccca ttccacattt cagtcatgcc gtgctctctg
     5401 ctgtcatgga ctttatcttc gagcatcctg acaacttgcg tgtagtggtc gaacccgatc
     5461 accgtaatga caaaatccac cgccttaata agcgcgttgg gttttttcat caacagcgtg
     5521 tccagcttgc cgataaggag acctacctcg ccttctgcac ccgcgagcaa tttgccatgg
     5581 ctaaggcacg ggaagaccgt gtcaacgagc cacacacgct gccccactat gacccctacc
     5641 gatcaacctg tggcaacgca ctaacgactg cgcctggcat tgccagtgaa tcgatcgaca
     5701 gcgaaacctg ggcgaaggtc aaccggcagc tggtgcaaaa agcgctatca gagctctgtc
     5761 atgagcgtat tttggaccct cgctgtgtcg acaccaccgc gctgtggtgt aactatcgtc
     5821 tttcaaccga ctccggcgac gttgaatatc gcttcaccgc tcaacgactg ccgctcaacc
     5881 actggcagat cgacctctac tccattgaaa ggatggagtc tggccgctcc catgaactcg
     5941 acgccatcga ctttatcgtc gactttcagg gctcgctcgg catcgacagt agtcgtctag
     6001 caagttactt agaagaggtt accagtacac tctgcagcag cgcctataag caacaacgtc
     6061 cctggcagag tgcaaaatat ctcgcttgcg ccgactttca gagtgtcgaa accggcatga
     6121 cagaggggca cccctgcttc atcgctaaca acggtcgtat cggcttttct gctgccgact
     6181 ttcgcgccta tgccccagaa gccgcagcac cggtgacgct gatgtggctc gccgcacaca
     6241 aacaacgcgc acacttctct gtcggcccgg atctcgatta ccagcagtta ctgtccgaag
     6301 agcttgatct cagcacccgc aaccgcttta cccagacgct cgtcgaacgc ggtgtcgagc
     6361 ctgatgatta cctatggatc cccatccacc cttggcagtg gcttaataag ctatcgaata
     6421 tttacgcgcc agagatcgca agcaaccact taatcctgct cggctacggt gatgacgcct
     6481 acctagcaca gcagtccatc cgtaccttct acaatatatc ccagcccaat aaacgctacg
     6541 tcaaaaccgc cctctccatc ctcaatatgg gcttcatgcg cggtctatcg gcctattaca
     6601 tgcgctctac tcctgccatc aatcagtggc tgcgcgaact gatcgataac gacgcctatt
     6661 tacaaagcaa gggtttcgac atgctgcgtg aaattgccgc cgtcggttat gaaataccgc
     6721 actacgacaa gcaacgcatt ggcgacaacc cataccgcaa gatgctcgcg gcactgtggc
     6781 gcgagaaccc acacagccgc ctgaagccgg accagcgtct tatgaccatg gcgtcactgc
     6841 tacatgtcga tccggcagga gaggctctat tgcccgcact catcgaggcc tcggggctct
     6901 ctatcgacga ttggctcgcg cgctacttcg atgtttactt aacgccacta ctgcactgct
     6961 tctatcaaca tgaactcgcc ttcatgcctc acggcgaaaa tctcatttta gtcttcgaca
     7021 acaatatccc cgtgcgggcc atcatgaaag atattggcga agagattgtg ctgcaaaaca
     7081 gccgacaacc tctacctgaa gatgtcgagc gcatcaaagt cgacgtgccc gaggagatgg
     7141 aggtgctagc gattttcacc gatgtctttg actgcttctt ccgctttatg tctgcgacgc
     7201 tgtatcaaca tgccgactac ccggtcgaag acttctggcg tggtgttggt cattgcattc
     7261 gtgactacca acacgataac ccacagttag ccgcacgctt tgaacagcat gacctatttg
     7321 ctgatgaatt tgccctgtca tgccttaacc gtctgcagct gcgtaataac cagcagatgg
     7381 tcgatctgac agatcccgct aacagcctct gctttgccgg caccctcaac aaccccgtcg
     7441 cgccgtaccg cccctcgcta cagctcgatt ctgaccacct acgttcacgt gaagaataag
     7501 taggcaaaaa taataattac cgcggccgtt gacggccgct ttgttaataa ggaagtacca
     7561 ctatgagtgg agagttagcc ccccgaccgc cgcgtttaat ggccgtagat ctcggccgcg
     7621 gcctcgccgt ttttttgatg atattagtcc acacgctctg gatgtatgcc gatcaagcaa
     7681 cacaatctgc atcgtggctt ggccacgtta ttcacttcat tggtaaaggt acccccgcat
     7741 ttctactctg catgggtatc tctatgctga catcacagca acaatcagcg cttgccaccc
     7801 tgcgcaaagg attactgatt ttgtgcttcg gctacttgat gaatggttta aagtttctcg
     7861 tccccatcgc gcttggcatc atgcccgaaa acttcataca ggcctatggc tgggcccacc
     7921 ccctcaacgc cagtcaatgg cgctatttat tactcaccgg cgatatcctg caaatggccg
     7981 ggctatcgct gattctgctc gccgctgttc gacagtattt gcataacaaa tacaccgtgc
     8041 tagtcgttgc cttggccatt ctagccatct cccgtgaact cagtggttac acccctcaaa
     8101 tcgccggcct cgattatctt gcgaaactat ttttcagtaa tagctttcat gtctacttcc
     8161 cgctctttcc gtggatgagt ttcatcttat tcggcatgtt catcggcatg cttatacgcg
     8221 ataacaactg gaactattgt accattttca accgtctgcc ggtcccagcg ctcgcttgca
     8281 tctgtatcgg tggcagcctc tgttactggc ggttcgacta tcacttcggt aacttctttc
     8341 accttggccc cggcggtgtc atctacctgt taggcatcaa cttcgcgctg atgtggctga
     8401 tccataaagt cactgaatcc ggtgtcaaca accgagccgt cgacttcctc aacttctgca
     8461 gtcaacgagt aacctcaatg tacgtcattc aatggacgct gatctgctgg ggtatgagcg
     8521 tcatcggttt ccagtcacta tcactgatgc agacccttgc catcatgcca gttatcgtcg
     8581 ttttaaccgt cctagttcaa cagagcaaag actatttggt caattctctg caacaactat
     8641 cgagtcaaaa aacgtcacta aaacattagt gtaagtattt gcgatagtcg ctttctaata
     8701 gtccccccgc cgcgattatt tttcggcggc tatcacgacg aattgttacc gcatcataaa
     8761 tctcattttc ttttgctcta ttctctaaag tcaaaacaaa gaccggatcg ctacgctttc
     8821 ggtgtaaata agacttcgcc gctctcatca actctcctgc atgaccagcg ccaacccatt
     8881 ttaactgtaa ataaagtgca acaacctctc ctacggattc gctattgtcg tgaaatcgaa
     8941 cataaacaaa acctgtaata ttattgtcga ctgtcgagac aatcagctta cccgggggcc
     9001 ctaaagcctt ctcccaagca ataactcgag cttctaaatc cagccctagc aagatatctt
     9061 catcaataat gctttgatgg gcgtggcacc aagagtcaat acgctgcttg gcaatagcta
     9121 aacaatcttc gcttgctgct tcccttactt tgactgctaa tttattcatc atctatctcc
     9181 aaaataacac ttgcaaacga tcaacgcgtt tatcgagccg accaccacat gaccacatga
     9241 ccacattctt ttaccaccgg tgtctttata gaacaagtgg acgcagatca ccgctaaact
     9301 ccataaaatg taatagctga acacattggg ccgacacttt aaagtttagc gcaaaacaaa
     9361 aataaaatta aaaacccgaa gaatcattga taaaagacca tattccgagt taaaaaaacg
     9421 cactaatcct cgctaacact gtttaaatca ttcaaatctt actgttcatt ttctaaatat
     9481 tacttttcgt tagtgttcgc gaaaggtgat ggcgttcaac gtttggttat attatgatct
     9541 tgcacataaa gtttggggcg acaacatcgg caaataaaaa tttccgtctg atctgccaca
     9601 aactatttat tggttaaata gtaactttga ctaacaatta gcacgactat ttcaactctt
     9661 agcagtctct aatagctttg attaataaag actctactac ccgcaacaaa aaatacgata
     9721 acaataattt tttactagga aaaaatattt ttcgaccttc acatcatctc tgacaggata
     9781 gttatctagt cagttcaact cgtttacatc gacttcccta attctcaatt cttatcgctg
     9841 agcgtttcac cgtataacct aacaaggtat catttaatgt ctcttaagat gaaagcactc
     9901 ccgttcgcca tcacggccgc gaccgtctcc ctcagctcct acggcgctgg ttttcaagtt
     9961 tcagaacagt ctgcgtccgg tttggggcgg gcctttgccg gtgaggctgc cgtggcagat
    10021 aatgctgctg taattgcaag aaatcccgcg gcaatgacgc gttttaaacg tgccgaggtg
    10081 tccggtgcca ttaccgtcat cgatgccgat atcgacgttg attccaccga tggcaacggt
    10141 cgccaccaga ccgcccacga tatagccccg actcaggccg tgcctgccgc ctattttgta
    10201 cagccaatca atgacaagtt agcatttggc ctagggctgt tttccaacta cggtgtcacc
    10261 agcgactatg acgagagctt tgcacccggt accgctgccg gcaaaacctc gcttatcacc
    10321 ttgaacctaa accccagcct tgcttataag gtcaacgacc aactcagtgt cggtggtggt
    10381 atcagcctcg tctatgccga tgccgagctc attcgtcgct atggtgccga tgccaactgg
    10441 tttcccacac accccgcccc cagcgacaaa acgattgaac ttgctggcga tacttacagc
    10501 tgggggtgga atgttggtgg tttgtacgag ttcgatgaga ataatcgttt tggcttaagc
    10561 tatcgtgcac aagttgatct caacttcgaa ggtgacttta ccgattacac cggtcaggtc
    10621 gttcccggct tacctagtcc cggcggtcaa aaagtcgatg gcgagctcga cattgtctta
    10681 cccgccaccg ccgagttctc aggcttccac cagctgaacg accgtgtctc tgtgcaatac
    10741 agcattctct ggaccgactg gagcgccttt aaagaaatta aggcaacctc ttctgactgc
    10801 agctaccacg gccagagtgg tgtctgtctc gccaaggatg aagacttcga agacagcatg
    10861 cgctacgcag tcggagccag ctacttgctc aaccctcagt ggacactgcg cgccggcctc
    10921 gcctatgacg aaaaaggcgg ccaaccgacg ctgagcattc ctgattccaa tcgttactgg
    10981 tacaccgccg gcgccactta ccactacagc gacagccttt ccttcgatgc cggccttgcc
    11041 tatgtccaga gcgaggaagc ctcgttcacc gaaggcggca ccttgttgga tgacgactac
    11101 gcacttaagt caaacggcga tgcctacctc gcttcactgc aggttaacta caagctctaa
    11161 ctctaagacg gggcgagatg ctctccccct caacccatct ttgacaggta tatcacatga
    11221 aaaaacgttt aatcacgctg ctcgttagca ctgccattac tctcgtcggc tgtggcggcg
    11281 gtggtggcgg cacctccggt gacgacaccg tccccaagcg ccccgaaaca caaattaaat
    11341 tcgatctgtt cgctgccaat aaagtactgg ttaccccatc gttcatcgcc atggatcaga
    11401 gtgatggcac cctcgccgcc gatggtttta atggcagcgc tgactacagc actaacatca
    11461 acgatcccgc agttgccatc ggcaagatgg atggctgggg gctcagcgta ccgatcgaca
    11521 ttgcctttga agggaaagac ttagaccccg ccagcgcttc agccggtttc gtgatcattg
    11581 aagcctttaa ccccacaacg ggcgtcgctg gtacgaccag agtactcgag gaaggccgcg
    11641 attacgctgt atctaccgtg ggtaagaagc tattggtgaa tttcttaatg ccgctacaac
    11701 cggccagcaa ctatatgttc gctgtgaccg accaactgaa agacgtcaac ggcaaggctg
    11761 tcggtgcctc cgtttcttac gagaagctca agtcgaacga caacgcgcca aacgaagagt
    11821 ttgccgccat tcaaaaagtc actcatgctg tcgaacaaac catcagccag gcgagcggca
    11881 ccaacagcaa agacatcatc ttctccacct ggttcgagac cgaatctgcg ggcaacagcc
    11941 tacacgctgt caaagtcgcc acctaccgca cgatacaggc aaagcttagc ggccaagacg
    12001 tcgccggcat ttggggagta gaggataacg ccaacattac cgtcgaagat ctcttcgaga
    12061 tcaccgagcc cacaaaacaa aatcctacgg atatagtttc cccgggtact aagcctgatc
    12121 aaatcgcctt gcttccaact ctatatgctg ccactcaagt cgagatatat aagggaacag
    12181 tcaccctccc ctattttctc gataacccat cggacgccgg caccagcccc gacggccaac
    12241 tcgaccaccc ttggcagagc gccacaccga gcctgcgcaa aatcgccatc gccctagccc
    12301 agggtgacga taacgccgcc gccatccagc agcagcttat cggctacggc atctccgaga
    12361 gtgagatggc tcagttattg agcaaccctg cggcacaggc ctccgtgctc gccaaactta
    12421 ctggcaagac tctgaccctc gccgacggca gcacccccct cgatagcgaa cgcctcgtga
    12481 cccgctacag cccgatgcc
//
