Select genomic region:
Overview
8.1
19.1
20.1

### Identified secondary metabolite regions using strictness 'relaxed'

c00008_NZ_CALE.. (original name was: NZ_CALERU010000008.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 8.1 | thiopeptide | 24,859 | 67,029 |

c00019_NZ_CALE.. (original name was: NZ_CALERU010000019.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 19.1 | arylpolyene,NRPS-like | 172,006 | 242,422 |

c00020_NZ_CALE.. (original name was: NZ_CALERU010000020.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 20.1 | RRE-containing | 224,049 | 245,308 | TP-1161 | RiPP:Thiopeptide | 16%

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 8.1 | thiopeptide | 24,859 | 67,029 |
Region 19.1 | arylpolyene,NRPS-like | 172,006 | 242,422 |
Region 20.1 | RRE-containing | 224,049 | 245,308 | TP-1161 | RiPP:Thiopeptide | 16%

No secondary metabolite regions were found in these records:
  c00001_NZ_CALE.. (original name was: NZ_CALERU010000001.1)
  c00002_NZ_CALE.. (original name was: NZ_CALERU010000002.1)
  c00003_NZ_CALE.. (original name was: NZ_CALERU010000003.1)
  c00004_NZ_CALE.. (original name was: NZ_CALERU010000004.1)
  c00005_NZ_CALE.. (original name was: NZ_CALERU010000005.1)
  c00006_NZ_CALE.. (original name was: NZ_CALERU010000006.1)
  c00007_NZ_CALE.. (original name was: NZ_CALERU010000007.1)
  c00009_NZ_CALE.. (original name was: NZ_CALERU010000009.1)
  c00010_NZ_CALE.. (original name was: NZ_CALERU010000010.1)
  c00011_NZ_CALE.. (original name was: NZ_CALERU010000011.1)
  c00012_NZ_CALE.. (original name was: NZ_CALERU010000012.1)
  c00013_NZ_CALE.. (original name was: NZ_CALERU010000013.1)
  c00014_NZ_CALE.. (original name was: NZ_CALERU010000014.1)
  c00015_NZ_CALE.. (original name was: NZ_CALERU010000015.1)
  c00016_NZ_CALE.. (original name was: NZ_CALERU010000016.1)
  c00017_NZ_CALE.. (original name was: NZ_CALERU010000017.1)
  c00018_NZ_CALE.. (original name was: NZ_CALERU010000018.1)
  c00021_NZ_CALE.. (original name was: NZ_CALERU010000021.1)
  c00022_NZ_CALE.. (original name was: NZ_CALERU010000022.1)

Compact view
c00008_NZ_CALE.. - Region 1 - thiopeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 24,859 - 67,029 nt. (total: 42,171 nt) Show pHMM detection rules used
thiopeptide: ((YcaO or TIGR03882) and ((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or PF07366 or PF06968 or PF04055) or thiostrepton)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Thiopeptides
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | thiopeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000938.1 |  | 0.21 | Other (Aminocoumarin) | fosfomycin | Streptomyces fradiae
BGC0000600.1 |  | 0.17 | RiPP | thurincin H | Bacillus thuringiensis
BGC0000554.1 |  | 0.17 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000513.1 |  | 0.16 | RiPP | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0001173.1 |  | 0.16 | RiPP | plantazolicin | Bacillus pumilus ATCC 7061
BGC0000569.1 |  | 0.16 | RiPP | plantazolicin | Bacillus velezensis FZB42
BGC0000563.1 |  | 0.16 | RiPP | venezuelin | Streptomyces venezuelae ATCC 10712
BGC0001120.1 |  | 0.16 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0001525.1 |  | 0.16 | Other | bartoloside 2, bartoloside 3, bartoloside 4 | Synechocystis salina LEGE 06155
BGC0001526.1 |  | 0.16 | Other | bartolosides E, bartolosides F, bartolosides G, bartolosides H, bartolosides I, bartolosides J, bartolosides K | Synechocystis salina LEGE 06099

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000938.1 |  | 0.54 | Other (Aminocoumarin) | fosfomycin | Streptomyces fradiae
BGC0000600.1 |  | 0.49 | RiPP | thurincin H | Bacillus thuringiensis
BGC0000554.1 |  | 0.48 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000513.1 |  | 0.47 | RiPP | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0001173.1 |  | 0.47 | RiPP | plantazolicin | Bacillus pumilus ATCC 7061
BGC0000569.1 |  | 0.47 | RiPP | plantazolicin | Bacillus velezensis FZB42
BGC0000563.1 |  | 0.47 | RiPP | venezuelin | Streptomyces venezuelae ATCC 10712
BGC0001120.1 |  | 0.47 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0001525.1 |  | 0.47 | Other | bartoloside 2, bartoloside 3, bartoloside 4 | Synechocystis salina LEGE 06155
BGC0001526.1 |  | 0.47 | Other | bartolosides E, bartolosides F, bartolosides G, bartolosides H, bartolosides I, bartolosides J, bartolosides K | Synechocystis salina LEGE 06099

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Thiopeptide predictions
Lists the possible core peptides for each biosynthetic enzyme, including the predicted class. Each core peptide shows the leader and core peptide sequences, separated by a dash. Predicted tail sequences are also shown.
No core peptides found.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
Thiopeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists its possible molecular weights and the scores for cleavage site prediction and RODEO. If relevant, other features, such as macrocycle and amidation, will also be listed.
No core peptides found.
c00019_NZ_CALE.. - Region 1 - NRPS-like,arylpolyene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 172,006 - 242,422 nt. (total: 70,417 nt) Show pHMM detection rules used
arylpolyene: (APE_KS1 or APE_KS2)
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | arylpolyene | NRPS-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001588.1 |  |  | 0.37 | Saccharide | exopolysaccharides | Burkholderia pseudomallei 1026b
BGC0000703.1 |  |  | 0.35 | Saccharide | kanamycin | Streptomyces kanamyceticus
BGC0001579.1 |  |  | 0.35 | RiPP | duramycin | Streptomyces cinnamoneus
BGC0001589.1 |  |  | 0.35 | Saccharide | exopolysaccharides | Burkholderia cenocepacia J2315
BGC0001526.1 |  |  | 0.33 | Other | bartolosides E, bartolosides F, bartolosides G, bartolosides H, bartolosides I, bartolosides J, bartolosides K | Synechocystis salina LEGE 06099
BGC0000487.1 |  |  | 0.33 | RiPP | carnocyclin | Carnobacterium maltaromaticum
BGC0001551.1 |  |  | 0.33 | RiPP | citrulassin E | Streptomyces glaucescens
BGC0001525.1 |  |  | 0.33 | Other | bartoloside 2, bartoloside 3, bartoloside 4 | Synechocystis salina LEGE 06155
BGC0000554.1 |  |  | 0.33 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000496.1 |  |  | 0.32 | RiPP | AmfS | Streptomyces griseus subsp. griseus NBRC 13350

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000858.1 |  | 0.57 | Other | ectoine | Methylobacter marinus
BGC0000852.1 |  | 0.57 | Other | ectoine | Sporosarcina pasteurii
BGC0000860.1 |  | 0.57 | Other | ectoine | Methylarcula marina
BGC0000853.1 |  | 0.57 | Other | ectoine | Streptomyces anulatus
BGC0000855.1 |  | 0.57 | Other | ectoine | Methylomicrobium kenyense
BGC0000854.1 |  | 0.56 | Other | ectoine | Methylomicrobium alcaliphilum 20Z
BGC0000856.1 |  | 0.56 | Other | ectoine | Methylophaga thalassica
BGC0000859.1 |  | 0.56 | Other | ectoine | Methylomicrobium alcaliphilum
BGC0000857.1 |  | 0.56 | Other | ectoine | Methylophaga alcalica
BGC0001538.1 |  | 0.55 | NRP, Polyketide | caboxamycin | Streptomyces sp. NTK 937

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00020_NZ_CALE.. - Region 1 - RRE-containing
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 224,049 - 245,308 nt. (total: 21,260 nt) Show pHMM detection rules used
RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RRE-containing | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000607.1 |  | 0.10 | RiPP | micrococcin P1 | Macrococcus caseolyticus
BGC0001472.1 |  | 0.06 | RiPP | berninamycin A | Streptomyces bernensis
BGC0000610.1 |  | 0.06 | RiPP | nosiheptide | Streptomyces actuosus
BGC0000615.1 |  | 0.06 | RiPP | TP-1161 | Nocardiopsis sp. TFS65-07
BGC0001423.1 |  | 0.06 | NRP, Polyketide | myxochromide C | Myxococcus hansupus
BGC0001421.1 |  | 0.06 | NRP, Polyketide | myxochromide B | Myxococcus sp.
BGC0001427.1 |  | 0.06 | NRP, Polyketide | myxochromide A | Myxococcus xanthus
BGC0001424.1 |  | 0.06 | NRP, Polyketide | myxochromide C | Myxococcus virescens
BGC0001425.1 |  | 0.06 | NRP, Polyketide | myxochromide A | Myxococcus xanthus DK 1622
BGC0001426.1 |  | 0.06 | NRP, Polyketide | myxochromide A | Myxococcus xanthus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000607.1 |  | 0.36 | RiPP | micrococcin P1 | Macrococcus caseolyticus
BGC0001472.1 |  | 0.27 | RiPP | berninamycin A | Streptomyces bernensis
BGC0000610.1 |  | 0.26 | RiPP | nosiheptide | Streptomyces actuosus
BGC0000615.1 |  | 0.24 | RiPP | TP-1161 | Nocardiopsis sp. TFS65-07
BGC0001423.1 |  | 0.24 | NRP, Polyketide | myxochromide C | Myxococcus hansupus
BGC0001421.1 |  | 0.24 | NRP, Polyketide | myxochromide B | Myxococcus sp.
BGC0001427.1 |  | 0.24 | NRP, Polyketide | myxochromide A | Myxococcus xanthus
BGC0001424.1 |  | 0.24 | NRP, Polyketide | myxochromide C | Myxococcus virescens
BGC0001425.1 |  | 0.24 | NRP, Polyketide | myxochromide A | Myxococcus xanthus DK 1622
BGC0001426.1 |  | 0.24 | NRP, Polyketide | myxochromide A | Myxococcus xanthus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names