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Overview
1.1
1.2
1.3
1.4

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP072608.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1.1 | NRPS-like | 1,745,087 | 1,786,837 |
Region 1.2 | arylpolyene | 1,881,171 | 1,934,942 | flexirubin | Other | 8%
Region 1.3 | thiopeptide | 2,135,498 | 2,176,213 | gentamicin | Saccharide | 3%
Region 1.4 | NRPS | 2,400,115 | 2,456,920 |

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1.1 | NRPS-like | 1,745,087 | 1,786,837 |
Region 1.2 | arylpolyene | 1,881,171 | 1,934,942 | flexirubin | Other | 8%
Region 1.3 | thiopeptide | 2,135,498 | 2,176,213 | gentamicin | Saccharide | 3%
Region 1.4 | NRPS | 2,400,115 | 2,456,920 |

No secondary metabolite regions were found in these records:
  NZ_CP072609.1

Compact view
NZ_CP072608.1 - Region 1 - NRPS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,745,087 - 1,786,837 nt. (total: 41,751 nt) Show pHMM detection rules used
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001535.1 |  | 0.28 | Other | branched-chain fatty acids | Streptomyces filamentosus
BGC0000340.1 |  | 0.27 | NRP | echoside A, echoside B, echoside C, echoside D, echoside E | Streptomyces sp. LZ35
BGC0001895.1 |  | 0.24 | Polyketide | huanglongmycin A, huanglongmycin B, huanglongmycin C | Streptomyces sp. CB09001
BGC0001723.1 |  | 0.23 | Polyketide | oviedomycin | Streptomyces antibioticus
BGC0000194.1 |  | 0.22 | Polyketide | actinorhodin | Streptomyces coelicolor A3(2)
BGC0002000.1 |  | 0.22 | Polyketide | setomimycin | Streptomyces aurantiacus JA 4570
BGC0000231.1 |  | 0.21 | Polyketide | griseusin | Streptomyces griseus
BGC0000221.1 |  | 0.21 | Polyketide | erdacin | uncultured soil bacterium V167
BGC0001399.1 |  | 0.21 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0001591.1 |  | 0.21 | Other | fatty acid enol ester | uncultured bacterium CSLC2

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001535.1 |  | 0.62 | Other | branched-chain fatty acids | Streptomyces filamentosus
BGC0000340.1 |  | 0.60 | NRP | echoside A, echoside B, echoside C, echoside D, echoside E | Streptomyces sp. LZ35
BGC0001895.1 |  | 0.58 | Polyketide | huanglongmycin A, huanglongmycin B, huanglongmycin C | Streptomyces sp. CB09001
BGC0001723.1 |  | 0.56 | Polyketide | oviedomycin | Streptomyces antibioticus
BGC0000194.1 |  | 0.55 | Polyketide | actinorhodin | Streptomyces coelicolor A3(2)
BGC0002000.1 |  | 0.55 | Polyketide | setomimycin | Streptomyces aurantiacus JA 4570
BGC0000231.1 |  | 0.54 | Polyketide | griseusin | Streptomyces griseus
BGC0000221.1 |  | 0.54 | Polyketide | erdacin | uncultured soil bacterium V167
BGC0001399.1 |  | 0.54 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0001591.1 |  | 0.54 | Other | fatty acid enol ester | uncultured bacterium CSLC2

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 1745086 - 1786837:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (gln)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_1523: gln
  Search NORINE for peptide: strict or relaxed
  AMP-binding (467..738): gln
  NRPSPredictor2: gln
  SVM prediction details:
    Predicted physicochemical class:
      N/A
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAQDLaVVDK
    Nearest Stachelhaus code:
      gln
    Stachelhaus code match:
      90% (moderate)

NZ_CP072608.1 - Region 2 - arylpolyene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,881,171 - 1,934,942 nt. (total: 53,772 nt) Show pHMM detection rules used
arylpolyene: (APE_KS1 or APE_KS2)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | arylpolyene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001075.1 |  | 0.27 | Terpene, Polyketide | aurachin RE | Rhodococcus erythropolis
BGC0001723.1 |  | 0.24 | Polyketide | oviedomycin | Streptomyces antibioticus
BGC0000231.1 |  | 0.24 | Polyketide | griseusin | Streptomyces griseus
BGC0000234.1 |  | 0.23 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000194.1 |  | 0.21 | Polyketide | actinorhodin | Streptomyces coelicolor A3(2)
BGC0001895.1 |  | 0.20 | Polyketide | huanglongmycin A, huanglongmycin B, huanglongmycin C | Streptomyces sp. CB09001
BGC0001897.1 |  | 0.20 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10
BGC0002000.1 |  | 0.19 | Polyketide | setomimycin | Streptomyces aurantiacus JA 4570
BGC0000220.1 |  | 0.19 | Polyketide | enterocin | Streptomyces maritimus
BGC0000219.1 |  | 0.19 | Polyketide, Saccharide | elloramycin | Streptomyces olivaceus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001075.1 |  | 0.61 | Terpene, Polyketide | aurachin RE | Rhodococcus erythropolis
BGC0001723.1 |  | 0.58 | Polyketide | oviedomycin | Streptomyces antibioticus
BGC0000231.1 |  | 0.58 | Polyketide | griseusin | Streptomyces griseus
BGC0000234.1 |  | 0.56 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000194.1 |  | 0.54 | Polyketide | actinorhodin | Streptomyces coelicolor A3(2)
BGC0001895.1 |  | 0.53 | Polyketide | huanglongmycin A, huanglongmycin B, huanglongmycin C | Streptomyces sp. CB09001
BGC0001897.1 |  | 0.52 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10
BGC0002000.1 |  | 0.52 | Polyketide | setomimycin | Streptomyces aurantiacus JA 4570
BGC0000220.1 |  | 0.51 | Polyketide | enterocin | Streptomyces maritimus
BGC0000219.1 |  | 0.51 | Polyketide, Saccharide | elloramycin | Streptomyces olivaceus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP072608.1 - Region 3 - thiopeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,135,498 - 2,176,213 nt. (total: 40,716 nt) Show pHMM detection rules used
thiopeptide: ((YcaO or TIGR03882) and ((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or PF07366 or PF06968 or PF04055) or thiostrepton)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Thiopeptides
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | thiopeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001217.1 |  | 0.26 | Other | PreQ0 Base | Streptomyces qinglanensis
BGC0000887.1 |  | 0.17 | Alkaloid | saxitoxin, gonyautoxin 2, gonyautoxin 3, toxin C2, toxin C3, gonyautoxin 5, decarbamoylsaxitoxin, decarbamoylgonyautoxin 2, decarbamoylgonyautoxin 3 | Dolichospermum circinale AWQC131C
BGC0001589.1 |  | 0.16 | Saccharide | exopolysaccharides | Burkholderia cenocepacia J2315
BGC0001588.1 |  | 0.16 | Saccharide | exopolysaccharides | Burkholderia pseudomallei 1026b
BGC0000846.1 |  | 0.16 | Other | tabtoxin | Pseudomonas syringae
BGC0001387.1 |  | 0.15 | Other | nucleocidin | Streptomyces calvus
BGC0000541.1 |  | 0.15 | RiPP | paenicidin A | Paenibacillus polymyxa
BGC0001391.1 |  | 0.15 | RiPP | thusin | Bacillus thuringiensis serovar rongseni
BGC0001586.1 |  | 0.15 | Saccharide | EPS273 | Pseudomonas stutzeri
BGC0000565.1 |  | 0.15 | RiPP | goadsporin | Streptomyces sp. TP-A0584

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001217.1 |  | 0.60 | Other | PreQ0 Base | Streptomyces qinglanensis
BGC0000887.1 |  | 0.48 | Alkaloid | saxitoxin, gonyautoxin 2, gonyautoxin 3, toxin C2, toxin C3, gonyautoxin 5, decarbamoylsaxitoxin, decarbamoylgonyautoxin 2, decarbamoylgonyautoxin 3 | Dolichospermum circinale AWQC131C
BGC0001589.1 |  | 0.47 | Saccharide | exopolysaccharides | Burkholderia cenocepacia J2315
BGC0001588.1 |  | 0.47 | Saccharide | exopolysaccharides | Burkholderia pseudomallei 1026b
BGC0000846.1 |  | 0.47 | Other | tabtoxin | Pseudomonas syringae
BGC0001387.1 |  | 0.46 | Other | nucleocidin | Streptomyces calvus
BGC0000541.1 |  | 0.46 | RiPP | paenicidin A | Paenibacillus polymyxa
BGC0001391.1 |  | 0.45 | RiPP | thusin | Bacillus thuringiensis serovar rongseni
BGC0001586.1 |  | 0.45 | Saccharide | EPS273 | Pseudomonas stutzeri
BGC0000565.1 |  | 0.45 | RiPP | goadsporin | Streptomyces sp. TP-A0584

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Thiopeptide predictions
Lists the possible core peptides for each biosynthetic enzyme, including the predicted class. Each core peptide shows the leader and core peptide sequences, separated by a dash. Predicted tail sequences are also shown.
No core peptides found.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
Thiopeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists its possible molecular weights and the scores for cleavage site prediction and RODEO. If relevant, other features, such as macrocycle and amidation, will also be listed.
No core peptides found.
NZ_CP072608.1 - Region 4 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,400,115 - 2,456,920 nt. (total: 56,806 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001050.1 |  | 0.38 | NRP, Polyketide | thalassospiramide A | Tistrella bauzanensis
BGC0000457.1 |  | 0.31 | NRP | vicibactin | Rhizobium etli CFN 42
BGC0000417.1 |  | 0.26 | NRP | rhodochelin | Rhodococcus jostii RHA1
BGC0001185.1 |  | 0.26 | NRP | bacillibactin | Bacillus velezensis FZB42
BGC0001873.1 |  | 0.26 | NRP | pyrrolizixenamide A | Xenorhabdus szentirmaii DSM 16338
BGC0001399.1 |  | 0.26 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0000342.1 |  | 0.26 | NRP | enniatin | Fusarium equiseti
BGC0001250.1 |  | 0.26 | NRP | epichloenin A | Epichloe festucae
BGC0001251.1 |  | 0.26 | NRP | epichloenin A | Epichloe festucae
BGC0001609.1 |  | 0.26 | NRP | gliovirin | Trichoderma virens Gv29-8

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001050.1 |  | 0.70 | NRP, Polyketide | thalassospiramide A | Tistrella bauzanensis
BGC0000457.1 |  | 0.65 | NRP | vicibactin | Rhizobium etli CFN 42
BGC0000417.1 |  | 0.60 | NRP | rhodochelin | Rhodococcus jostii RHA1
BGC0001185.1 |  | 0.60 | NRP | bacillibactin | Bacillus velezensis FZB42
BGC0001873.1 |  | 0.59 | NRP | pyrrolizixenamide A | Xenorhabdus szentirmaii DSM 16338
BGC0001399.1 |  | 0.59 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0000342.1 |  | 0.59 | NRP | enniatin | Fusarium equiseti
BGC0001250.1 |  | 0.59 | NRP | epichloenin A | Epichloe festucae
BGC0001251.1 |  | 0.59 | NRP | epichloenin A | Epichloe festucae
BGC0001609.1 |  | 0.59 | NRP | gliovirin | Trichoderma virens Gv29-8

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 4, location 2400114 - 2456920:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (tyr - ser)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_2084: gln
  Search NORINE for peptide: strict or relaxed
  AMP-binding (452..724): gln
  NRPSPredictor2: gln
  SVM prediction details:
    Predicted physicochemical class:
      N/A
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAQDLaVVDK
    Nearest Stachelhaus code:
      gln
    Stachelhaus code match:
      90% (moderate)
ctg1_2085: tyr - ser
  Search NORINE for peptide: strict or relaxed
  AMP-binding (457..830): tyr
  NRPSPredictor2: tyr
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aromatic
    Large clusters prediction:
      phe, trp, phg, tyr, bht
    Small clusters prediction:
      tyr, bht
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DASTIAAVCK
    Nearest Stachelhaus code:
      tyr
    Stachelhaus code match:
      100% (strong)
  AMP-binding (2935..3353): ser
  NRPSPredictor2: ser
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      ser
    Single AA prediction:
      ser
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVWHFSLVDK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      100% (strong)