LOCUS       NZ_CP040441.1          10366 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP040441.1 Halalkalibacterium halodurans isolate LB-1 chromosome,
            complete genome.
ACCESSION   NZ_CP040441
VERSION     NZ_CP040441.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 13:11:56
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 307877
            Orig. end    :: 318243
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10366
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[312877:313243](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5366
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10366
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10366
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             1107..1868
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 206.1; E-value:
                     1e-62)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_285"
                     /transl_table=11
                     /translation="MSDIILNVQQLHKDYVGEVNYKALKGIDFQLKRNEFVSVMGPSGS
                     GKTTFLNCISTIDRPTNGSITINQKNPYELNDEDLAKFRRSELGFVFQDFNLVHTLTVE
                     ENILLPLTLDAVNAKEMTSRLAEVVEFLGIEEIMKKRTFEISGGQKQRVAIARAVIHQP
                     SLLLADEPTGNLDSKAANSVMTLFQSIHETFQTSLLMVTHDPYVASFAERVIFMQDGML
                     YNEIQRGDHKKQFYQEIVDTLTFLGGGYHEL"
     PFAM_domain     1176..1622
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_285_0001"
                     /evalue="2.10E-33"
                     /label="ctg1_285"
                     /locus_tag="ctg1_285"
                     /protein_end="172"
                     /protein_start="23"
                     /score="115.8"
                     /tool="antismash"
                     /translation="LKGIDFQLKRNEFVSVMGPSGSGKTTFLNCISTIDRPTNGSITIN
                     QKNPYELNDEDLAKFRRSELGFVFQDFNLVHTLTVEENILLPLTLDAVNAKEMTSRLAE
                     VVEFLGIEEIMKKRTFEISGGQKQRVAIARAVIHQPSLLLADEPT"
     CDS             1858..3708
                     /gene_functions="transport (smcogs) SMCOG1243:ABC
                     transporter, permease component (Score: 218.1; E-value:
                     4.1e-66)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_286"
                     /transl_table=11
                     /translation="MSFNHIVIQNIVRDKWTYISYFLSSVFSILVFFFFLITAFHPMMD
                     AIDANSSLGIAMILCSMIVYIFSFIFIIYSMLAFLKKKTKSLGVFIISGASTKQVRKMV
                     FRENMLIAFAAIITAIVVGLIVSPLFLMVVKNILEAESFGMYVPVQAIATTFILFSVLF
                     FIVSKITTRFIKKEEAVQLLKADVTQEKLILPTPWRFLLSILVSAVCLLPFKVNPDIIE
                     SLGILYFVILFISLLITFYLVLTQGTWFTIRGLQKSSSYYRKTNMLFVSNLQAKGKSHA
                     HIIYLLSILLLAVFVTTSVLYSSYYNVEENTEAVYPYSFQYISHPDNPIEKVQQDIEFI
                     ESTLEQTVGDFDAYQSAFKTDEDRRIGFMSNTNFNALGTHQAITLNDNEYYVVAGNVGM
                     IPNTDTIQDYVDDPLQYVGLEEGMILTTGFRAVYYVIPEAIYEALNYPEYHVFAYELKD
                     WTEKRDVAEKIESQIMTEPDERYVTSKISLYHDELFVKRIMFFIGFMLSLLFLSAAMSI
                     LYFYLQTSLAGEKEKYLGIRKIGLSMKEMSVIVTRELSILIFVPFTIATILLFIVLFSI
                     RDALSPAFFQMTNVGVGIILLLFTLSFFIIRKAYLKKLVE"
     PFAM_domain     2110..2391
                     /aSDomain="FtsX"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02687.23"
                     /description="FtsX-like permease family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_286_0002"
                     /evalue="2.00E-08"
                     /label="ctg1_286"
                     /locus_tag="ctg1_286"
                     /protein_end="178"
                     /protein_start="84"
                     /score="34.7"
                     /tool="antismash"
                     /translation="KSLGVFIISGASTKQVRKMVFRENMLIAFAAIITAIVVGLIVSPL
                     FLMVVKNILEAESFGMYVPVQAIATTFILFSVLFFIVSKITTRFIKKEE"
     CDS             complement(4630..4818)
                     /locus_tag="ctg1_287"
                     /transl_table=11
                     /translation="MRKMGLTLVLASIFVLVACNADENETESVDQNAEVEEVTEDELEQ
                     DQEEFEDVVEETDDEEE"
     CDS             5001..5366
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Lactococcin_972"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_288"
                     /sec_met_domain="Lactococcin_972 (E-value: 6.4e-07,
                     bitscore: 27.8, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKIFFSVAAATFLALASQQVLAAEPETVSEQEGVSNADVTPFET
                     VDAQSTVWIWSRGITNVTDTRKTAYSNYYHRDRPHRSAAQLGNDRAVSPLGGPGATTYA
                     SIRGNKNLPATFYRFTY"
     PFAM_domain     5163..5327
                     /aSDomain="Lactococcin_972"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09683.12"
                     /description="Bacteriocin (Lactococcin_972)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_288_0003"
                     /evalue="2.50E-09"
                     /label="ctg1_288"
                     /locus_tag="ctg1_288"
                     /protein_end="109"
                     /protein_start="54"
                     /score="37.6"
                     /tool="antismash"
                     /translation="WSRGITNVTDTRKTAYSNYYHRDRPHRSAAQLGNDRAVSPLGGPG
                     ATTYASIRGN"
     CDS             5454..7679
                     /locus_tag="ctg1_289"
                     /transl_table=11
                     /translation="MKRLFLVFLAASFLFSAYVSYLLETDKEVHAWSAAAYADFAVTIP
                     RIDLLGPDIVLSVLEEAATHHQVNLLRDVQLLGEGDKIALTTFALLTEKSPFLEAIPLR
                     HGSRLTSEDTRDGDLILSSRRTKEDVEEIKGTIQTLSQTHTRTVRPLHQFPNYVSPYAT
                     YQVEQAGTVTKEQFSATLADLFNHYLEDYVEELEPLTVDDFAVQTEPSHVSTTFDPTFP
                     KTLAWTLWGITGLMLMFYIMRNGKTVAIYSMHGFSLFKIWRRLIGNACGGFFAFYLLFL
                     PLLAFALFGWQPRYLFATMVTGSWPFLLLLAISFLFVFYSSRSSLIESIKNNTKTKLFL
                     IVSQVAKVVALVSVIVFLLQIADRLTIMEEVRNSMTDWAFGKDYGEFYPHSIGYDQEEM
                     NQESGLWQTDISLTKSLYPVLNAVGALYIDAVLYEEEWLRMATEYSQEHIRSIRVNPNY
                     LQAFPLVDENNKRIAIQEEETNRVLLVPEQYKDQKEDIIAYFKEDYAYWATMPEYQAES
                     YSHLQEQTFDIIWLASSQEVFSFNLYVFPNEGNLIVDPIIQVLTENNSYPMERDFFRGS
                     VGNDPLKVKLLDQNTAKTYEHYLPLLRDLQLDDNAKHLVTVNEQAQKDITEIQRALTLD
                     TILFVLTATIALFMIVQSSHLLFAQHKKRFLLRRLFGHSLFRAYRNVLFWTLATWVVIL
                     GIALYRHSGTQYLAIVVLVLFLTEVVVTSVVLMRLEQKNKVSVLKGE"
     aSDomain        5592..7673
                     /aSDomain="TIGR01654"
                     /aSTool="tigrfam"
                     /description="bact_immun_7tm: bacteriocin-associated
                     integral membrane protein"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_289_0001"
                     /evalue="2.50E-243"
                     /identifier="TIGR01654"
                     /label="ctg1_289"
                     /locus_tag="ctg1_289"
                     /protein_end="740"
                     /protein_start="46"
                     /score="807.4"
                     /tool="antismash"
                     /translation="IDLLGPDIVLSVLEEAATHHQVNLLRDVQLLGEGDKIALTTFALL
                     TEKSPFLEAIPLRHGSRLTSEDTRDGDLILSSRRTKEDVEEIKGTIQTLSQTHTRTVRP
                     LHQFPNYVSPYATYQVEQAGTVTKEQFSATLADLFNHYLEDYVEELEPLTVDDFAVQTE
                     PSHVSTTFDPTFPKTLAWTLWGITGLMLMFYIMRNGKTVAIYSMHGFSLFKIWRRLIGN
                     ACGGFFAFYLLFLPLLAFALFGWQPRYLFATMVTGSWPFLLLLAISFLFVFYSSRSSLI
                     ESIKNNTKTKLFLIVSQVAKVVALVSVIVFLLQIADRLTIMEEVRNSMTDWAFGKDYGE
                     FYPHSIGYDQEEMNQESGLWQTDISLTKSLYPVLNAVGALYIDAVLYEEEWLRMATEYS
                     QEHIRSIRVNPNYLQAFPLVDENNKRIAIQEEETNRVLLVPEQYKDQKEDIIAYFKEDY
                     AYWATMPEYQAESYSHLQEQTFDIIWLASSQEVFSFNLYVFPNEGNLIVDPIIQVLTEN
                     NSYPMERDFFRGSVGNDPLKVKLLDQNTAKTYEHYLPLLRDLQLDDNAKHLVTVNEQAQ
                     KDITEIQRALTLDTILFVLTATIALFMIVQSSHLLFAQHKKRFLLRRLFGHSLFRAYRN
                     VLFWTLATWVVILGIALYRHSGTQYLAIVVLVLFLTEVVVTSVVLMRLEQKNKVSVLKG
                     "
     PFAM_domain     7371..7673
                     /aSDomain="DUF1430"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07242.13"
                     /description="Protein of unknown function (DUF1430)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_289_0004"
                     /evalue="2.30E-24"
                     /label="ctg1_289"
                     /locus_tag="ctg1_289"
                     /protein_end="740"
                     /protein_start="639"
                     /score="85.6"
                     /tool="antismash"
                     /translation="VLTATIALFMIVQSSHLLFAQHKKRFLLRRLFGHSLFRAYRNVLF
                     WTLATWVVILGIALYRHSGTQYLAIVVLVLFLTEVVVTSVVLMRLEQKNKVSVLKG"
     CDS             7683..8324
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 193.8; E-value:
                     6.1e-59)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_290"
                     /transl_table=11
                     /translation="MAAAIVELTDISKSFHSETVLRDFNLTIDRGEMIAITGPSGSGKT
                     TILNIIGLLEKEDRGTVRLFGKNKPAYHSKQALQFRKSKIAYLFQNFALMDDETVSKNL
                     DVPLELIKGSRTFKQQKKKEVLEKVGLFNKLNKKVHSLSGGEQQRVAIARLLLRPCDLL
                     LADEPTGSLDMANRNVILDLLCQLNQEGMTIVIVTHDPEVADRCDRVITL"
     aSDomain        7704..8321
                     /aSDomain="TIGR03608"
                     /aSTool="tigrfam"
                     /description="L_ocin_972_ABC: putative bacteriocin export
                     ABC transporter, lactococcin 972 group"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_290_0002"
                     /evalue="3.40E-89"
                     /identifier="TIGR03608"
                     /label="ctg1_290"
                     /locus_tag="ctg1_290"
                     /protein_end="213"
                     /protein_start="7"
                     /score="295.7"
                     /tool="antismash"
                     /translation="LTDISKSFHSETVLRDFNLTIDRGEMIAITGPSGSGKTTILNIIG
                     LLEKEDRGTVRLFGKNKPAYHSKQALQFRKSKIAYLFQNFALMDDETVSKNLDVPLELI
                     KGSRTFKQQKKKEVLEKVGLFNKLNKKVHSLSGGEQQRVAIARLLLRPCDLLLADEPTG
                     SLDMANRNVILDLLCQLNQEGMTIVIVTHDPEVADRCDRVITL"
     PFAM_domain     7743..8189
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_290_0005"
                     /evalue="3.20E-32"
                     /label="ctg1_290"
                     /locus_tag="ctg1_290"
                     /protein_end="169"
                     /protein_start="20"
                     /score="112.0"
                     /tool="antismash"
                     /translation="LRDFNLTIDRGEMIAITGPSGSGKTTILNIIGLLEKEDRGTVRLF
                     GKNKPAYHSKQALQFRKSKIAYLFQNFALMDDETVSKNLDVPLELIKGSRTFKQQKKKE
                     VLEKVGLFNKLNKKVHSLSGGEQQRVAIARLLLRPCDLLLADEPT"
     CDS             complement(8468..8848)
                     /locus_tag="ctg1_291"
                     /transl_table=11
                     /translation="MKIEHVAIWVKDLEAMKTFYVKYFNGHANSKYHNKDKKFESYFLT
                     FDGGARLEIMCQSGIDKPDQDDRMGWAHIAISLGSKEAVNQMTGRLHNDGYRLVNGPRV
                     TGDGYYESVIEDPEGNFLELTV"
     PFAM_domain     complement(8477..8845)
                     /aSDomain="Glyoxalase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00903.27"
                     /description="Glyoxalase/Bleomycin resistance
                     protein/Dioxygenase superfamily"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_291_0006"
                     /evalue="4.00E-11"
                     /label="ctg1_291"
                     /locus_tag="ctg1_291"
                     /protein_end="124"
                     /protein_start="1"
                     /score="43.3"
                     /tool="antismash"
                     /translation="KIEHVAIWVKDLEAMKTFYVKYFNGHANSKYHNKDKKFESYFLTF
                     DGGARLEIMCQSGIDKPDQDDRMGWAHIAISLGSKEAVNQMTGRLHNDGYRLVNGPRVT
                     GDGYYESVIEDPEGNFLEL"
     CDS             complement(8947..9744)
                     /locus_tag="ctg1_292"
                     /transl_table=11
                     /translation="MMTTPIYVVDAFTNQAFKGNPAAVCVLPTSRDDIWMQHVASEMNL
                     SETAFLHPYQDGYSLRWFTPNTEVDLCGHATLASARILWELDHISAEQPITFYTKSGIL
                     TASKRGEWIELDFPSEQPKQENVYPNELIDGLGIQPLYVGRNRFDYLIEIDSEQRLKEL
                     NPNFSLLEQIDTRGIIVTSKSTSTEYDFISRCFFPAVGVNEDPVTGSAHCCLGPYWQEK
                     LNKNEFLAYQASKRGGILKIKLQHDRVFLLGQAITVLRSELLL"
     PFAM_domain     complement(8968..9720)
                     /aSDomain="PhzC-PhzF"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02567.18"
                     /description="Phenazine biosynthesis-like protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_292_0007"
                     /evalue="2.40E-68"
                     /label="ctg1_292"
                     /locus_tag="ctg1_292"
                     /protein_end="259"
                     /protein_start="8"
                     /score="230.7"
                     /tool="antismash"
                     /translation="VDAFTNQAFKGNPAAVCVLPTSRDDIWMQHVASEMNLSETAFLHP
                     YQDGYSLRWFTPNTEVDLCGHATLASARILWELDHISAEQPITFYTKSGILTASKRGEW
                     IELDFPSEQPKQENVYPNELIDGLGIQPLYVGRNRFDYLIEIDSEQRLKELNPNFSLLE
                     QIDTRGIIVTSKSTSTEYDFISRCFFPAVGVNEDPVTGSAHCCLGPYWQEKLNKNEFLA
                     YQASKRGGILKIKLQHDRVFLLGQAITVL"
     aSDomain        complement(9052..9741)
                     /aSDomain="TIGR00654"
                     /aSTool="tigrfam"
                     /description="PhzF_family: phenazine biosynthesis protein,
                     PhzF family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_292_0003"
                     /evalue="1.10E-38"
                     /identifier="TIGR00654"
                     /label="ctg1_292"
                     /locus_tag="ctg1_292"
                     /protein_end="231"
                     /protein_start="1"
                     /score="131.3"
                     /tool="antismash"
                     /translation="MTTPIYVVDAFTNQAFKGNPAAVCVLPTSRDDIWMQHVASEMNLS
                     ETAFLHPYQDGYSLRWFTPNTEVDLCGHATLASARILWELDHISAEQPITFYTKSGILT
                     ASKRGEWIELDFPSEQPKQENVYPNELIDGLGIQPLYVGRNRFDYLIEIDSEQRLKELN
                     PNFSLLEQIDTRGIIVTSKSTSTEYDFISRCFFPAVGVNEDPVTGSAHCCLGPYWQEKL
                     NKNEFLAY"
ORIGIN
        1 gttatttata aaggatcatc tcagctttat tcttttgtat ctgataacgt ttatctgctt
       61 gccttttatc attgaacaat tagatggttt tgaaaatcat tatgactatt ttagtttttt
      121 agccatcact ttattaataa gtctacttgt tattcgctat cttcgtcgta aaaaaatgta
      181 tacacattta aaaaaagaaa atttggacca agctgatttt cttatctatc gtcctcatgc
      241 tccaatagaa aaagcatatg ccaatcaatt aaaggaattt tcctccttac tcttaaaaga
      301 acaggacacg tatcaaaatt ttttacagga acagcagcta cttatttcac atgcggtgca
      361 tcagatgaag acgcctattt ctgtcatgca attgcttgtt caatcgaatc aaacaaacga
      421 tgtcaaatcg ttgggagaat ggcagaaagt agaagccgaa tgcgataaaa tatacttttc
      481 gttaaatcag ctattgtctt atagccgctc tacccaatta ttatctgatt tgaaaattga
      541 agcgatgcca ctaaagaaaa tcatccaaga ggttattaat gatttaaaag attactttat
      601 tgaggaagaa ctatttccca aggtgacaat agcggaagaa gttattcttt attcagaccg
      661 aaagtggatg aaagtagttg tctaccaact gcttagtaat gcgataaaat atggtgagaa
      721 gcactctact gttcatattt attacaggaa tggtcagtta tcgattcata acagagggga
      781 aaccattcca aaaagcgaga tcaaccgctt attcaatttg ttctatacag gttcaaaagg
      841 acggaaaaga agtgaagcaa caggaatagg tttatactta gtcaaaagga ttttggttac
      901 gctagatcac ccgtttgagt taacgtctca tcatcaagaa accactttca ccattgaact
      961 ttcgaaaagt attagtacgg ctgccgattg aggcagccgt tttaaatgtg tcaatattgt
     1021 cactttgccg tcatgattct aaatgttaag gaatggacta cctcggtata gtaaagttaa
     1081 caatgaaaaa aacaggagtg gtatatatgt cagatatcat attaaatgtt caacaactcc
     1141 ataaggatta tgtgggagag gtgaactata aagcattaaa aggcattgac tttcaactga
     1201 aacgtaatga atttgtctct gtaatgggcc catctggaag tgggaagacg acatttttaa
     1261 attgtatatc aaccatagac cgtccgacaa atggttctat tacaattaac caaaaaaatc
     1321 catatgaact gaatgatgaa gatcttgcaa agtttcgacg tagtgaattg ggttttgttt
     1381 ttcaagattt taacttggtt cacacattaa ccgtagaaga aaacatttta ttaccattga
     1441 cactcgatgc agtgaatgca aaggaaatga catcccgttt agcggaagtc gttgagtttt
     1501 taggaattga agaaatcatg aagaagagaa cctttgaaat ttcaggggga cagaagcaac
     1561 gtgtagccat tgcacgagcc gttattcatc agcctagtct attattagca gatgagccga
     1621 cggggaatct ggactctaaa gcagcaaata gtgtgatgac gctatttcaa tccattcacg
     1681 aaacgtttca aacctcttta ttaatggtca cacatgatcc gtatgttgcc agttttgctg
     1741 agcgagtaat ttttatgcaa gacgggatgc tctacaatga aatacagaga ggtgaccaca
     1801 agaagcaatt ctatcaagaa attgtagata cactgacatt tctgggcggt ggatatcatg
     1861 agctttaatc atattgtcat tcaaaatata gtacgggata aatggaccta tatttcgtat
     1921 tttctgagca gcgtcttttc tattttagtc tttttctttt ttttgattac tgcctttcat
     1981 ccaatgatgg atgcaatcga tgcgaatagc tcacttggaa tagccatgat tttatgtagt
     2041 atgattgtct atattttttc ttttattttt attatttatt cgatgctggc ttttttaaag
     2101 aagaaaacca aaagccttgg cgtctttatc atttctggag catcgacgaa gcaagtgcgg
     2161 aaaatggtgt tccgagaaaa tatgctgatt gcttttgcgg caattattac agccattgtt
     2221 gttggattaa tcgtttctcc tctgttttta atggtcgtta aaaatatctt ggaggcagaa
     2281 agctttggaa tgtatgtacc cgtacaagcg attgcaacga cattcatttt atttagtgtt
     2341 ttatttttca ttgtttccaa aataacgaca cgatttatca agaaagaaga agctgtacaa
     2401 ctgttaaaag cagatgtaac acaggaaaaa ttaatacttc caactccatg gaggttcctt
     2461 ttatccatct tagtgagtgc agtttgttta ctacctttca aagtaaatcc agatatcatt
     2521 gaaagcttag gaattcttta ttttgtgatt ttgtttatca gtctgttaat tacgttttat
     2581 ttggtattaa cccaaggaac ttggtttacg attcggggat tgcaaaaaag ctcctcgtat
     2641 tacagaaaaa cgaatatgtt atttgtatcg aatttacaag ccaaaggcaa atcacatgct
     2701 catatcattt atttgctcag tattttactg cttgccgtat ttgttacgac gagtgttttg
     2761 tacagttcgt attataatgt cgaagaaaat acggaagctg tatatccgta tagctttcaa
     2821 tatatttcac atccagataa tcctatagaa aaagtacagc aagatattga atttatagag
     2881 tcaacccttg agcaaacagt gggagatttc gatgcgtatc aatctgcgtt caaaacagac
     2941 gaagaccgca ggattggctt catgtccaat actaatttca acgcactagg cacacaccag
     3001 gcgataacac ttaacgataa tgaatattat gttgtagcag gaaatgtggg aatgattcca
     3061 aatacggata ccattcagga ttatgtggat gaccctcttc agtacgtagg attagaagaa
     3121 ggaatgattc ttacaacagg atttcgggca gtatattatg ttattccaga agcgatttat
     3181 gaagcactca attatccaga atatcatgtg tttgcctatg aattgaagga ttggacagag
     3241 aaacgggatg tagcagaaaa aatagaatca caaatcatga cagaaccaga tgagcgttat
     3301 gtcacatcga aaatttcatt atatcatgat gaattatttg tgaagaggat catgtttttt
     3361 attggtttta tgctgagtct gcttttttta agtgcagcca tgagtattct ttatttttac
     3421 ttgcagacct ctttagcggg tgaaaaagaa aaatatttgg gcattcgcaa aatcgggcta
     3481 tctatgaaag aaatgagtgt gattgtgaca agagaattat ccatactgat ttttgtccct
     3541 tttacaattg ctacgatttt attatttatc gtgttattca gtattcgtga tgcactttca
     3601 ccagcatttt ttcagatgac taacgttggt gtaggaatta ttttgctgtt gtttactctg
     3661 agctttttta ttatacgcaa ggcatattta aaaaaattgg tagagtaaat gcacgttagc
     3721 cgtcgtttta gatcaaacct taatttaaat ctacaggaga ttgtagattt tgaaaaagga
     3781 tatacctttt ttaccccttt ggattatcgt gtccaaaggg gttatttatc gaaacgtatt
     3841 ccacaatcag gcgcgatggc taaaaatcaa tttgaaattt tagaccaaag gacctggaag
     3901 ttgttcaggt gagttgggtt attaggaaag gatcatatta tgaaaaattg actaacctct
     3961 tgtgaaaatg aaggtaattt gaaataattg ttagtaagcg atgggcagaa aagagggagg
     4021 gaattgtaat gaataatata tcagtatcct gatggtagta taatgcgaat tgaacagagt
     4081 atcgcacttt acgcatggca tggtaatcac catttagcac atattcaaca agctttaaga
     4141 agtaccaagt aaggattata aagcaattac gcaggcatta agaaaaggat aatagtgccc
     4201 cgagtctgaa ggcttgtcaa aaggcctttg aatccttcaa acaacaatgg accgcttatc
     4261 cagagaaact ttggacaagt cgattagttc tttgactatg ccaacgccat tcgcaaaatc
     4321 gacttacgcc gtggaaagca tccgttccag cctcaggaaa gtgacgaaaa aaggagcatt
     4381 cccccatgag aatgccctat gaaaaggatt gtaattacgc attaaaagaa ctggaaaata
     4441 agatggggtg gcgggtaccc gaaacgggtc cattgtcagg aaccagctgc tccttcatga
     4501 tgagctgaaa gatagggttt taaaatagcc tcagtaacgt ggcaaacccg ctagttttgt
     4561 ccccgtctac taatcttagt cgttttttgt ctcgcaatct atgggtttca atctacctta
     4621 aaccaaagat tattcctctt cgtcatctgt ttcttccaca acgtcttcaa attcttcttg
     4681 gtcttgctcc aattcgtctt ctgttacttc ttccacttct gcattttggt caacgctttc
     4741 cgtttcattt tcatctgcat tgcatgctac caagacaaaa atgctagcaa gcactaacgt
     4801 caatcccatt tttcgcatct aagacactcc ttcataaagc taagttttat tctactctaa
     4861 acaattgcac atgtagttgt caatgtgttc caataaaaaa ccgatattct acaaattatt
     4921 ctattaattt actaaaaagg cattgacaaa tttttcaaca atttatagaa ttaatttgca
     4981 cccaaaaatc ggaaaattaa atgaaaaaga ttttcttttc agtagctgca gccacatttc
     5041 tagcacttgc ttcccaacaa gtattggccg ctgaaccaga aacggtttca gaacaagagg
     5101 gcgtatcaaa tgccgatgtg acgccatttg aaacagtcga tgcccagagc acggtttgga
     5161 tctggtcaag aggcattacc aatgttacag acactcgaaa aacggcttat tctaattact
     5221 atcatcgtga caggccgcac cgttctgctg cacagttagg gaatgatcga gccgtctcgc
     5281 cgctaggcgg tccgggagca actacctatg ctagcatccg cggcaacaaa aacttaccag
     5341 caacgttcta tcgttttacg tactaaacat gccgcttcgt ccagtatcta ctgggcgaag
     5401 cgcttcattt ccacgataca tataacagga atgattacga aggggtttat ttcatgaagc
     5461 gtctttttct cgtttttttg gctgcttctt ttctgttttc ggcttatgtt tcgtatttac
     5521 tggagacaga caaagaagtg cacgcatggt cggcagcagc gtatgctgat tttgctgtta
     5581 cgattccacg aatcgatttg ttagggcctg atattgtgtt gtctgtgtta gaggaagcag
     5641 ctacccatca tcaggtaaat ttgttgcgtg atgtccaact ccttggggaa ggcgacaaga
     5701 ttgccttgac gacgtttgcc ttgctgacag aaaaaagccc ctttctagag gcgattccac
     5761 ttcgacacgg ctctcgttta acgagtgaag atacccgtga tggtgacttg atcttgtctt
     5821 ctcggcgaac gaaggaagac gttgaggaaa tcaaagggac gatacaaaca ttgagccaga
     5881 cacatacacg aacggttagg ccgttgcacc agtttcctaa ctatgtctcg ccctatgcta
     5941 cctatcaagt ggaacaagct ggtactgtta cgaaagagca gttttccgcc acgcttgccg
     6001 atttattcaa ccattacctt gaagactatg tggaagagct tgaaccgtta acagtcgatg
     6061 attttgctgt tcaaacagag cctagtcatg tgagcacaac atttgatcct acctttccga
     6121 aaacgttagc atggacgctt tggggaataa cagggctgat gctcatgttt tacattatgc
     6181 gaaacggcaa aacagtcgcg atttatagca tgcacggttt ttcgcttttt aagatatggc
     6241 gacgattgat cggcaatgcc tgtggaggtt tttttgcttt ttatttgttg ttcttgcccc
     6301 tgttggcttt tgccttgttt ggctggcaac ctcgctatct cttcgctaca atggttaccg
     6361 gatcatggcc attcctgctt ctgctggcga tatccttttt gtttgtgttt tatagcagtc
     6421 gttcttcctt aatcgagagc attaaaaaca acacgaaaac gaagctgttt ttaatcgtaa
     6481 gccaagtagc caaggtggtc gccctcgttt ctgtcattgt ttttttgcta caaatcgcgg
     6541 atcgcctgac aataatggaa gaagtgcgta actcgatgac cgattgggcg ttcggtaaag
     6601 attacggcga attttatccc cattctatcg gttacgacca agaagaaatg aaccaggaga
     6661 gtggcttatg gcaaacagat atttccttaa ctaagagctt gtatccagtg ctaaatgctg
     6721 tgggcgctct ctatatagat gcagtacttt atgaagaaga atggttgcga atggctacgg
     6781 aatattcaca agaacatatt cgttcaatac gagtgaaccc aaactattta caagcttttc
     6841 cgctagtaga tgagaataat aaacgtattg ccattcagga agaagaaacc aatcgtgtgt
     6901 tattggttcc tgagcaatat aaggaccaga aagaagatat tattgcttac tttaaagaag
     6961 attatgcgta ttgggcaacg atgcccgaat atcaagcaga gtcttattcc cacttgcaag
     7021 agcaaacgtt tgacatcatt tggctcgctt cgtctcaaga agtgtttagc tttaatctct
     7081 atgtcttccc aaacgaaggc aatctaattg ttgaccctat catacaagtc cttacggaga
     7141 ataacagcta tccaatggaa cgagatttct ttcgtggctc agtcggaaat gatccgctaa
     7201 aagtcaaact gttggaccaa aatacagcga aaacctatga acactatctt ccgcttttgc
     7261 gcgacttgca gcttgatgac aatgccaaac acttggtgac cgttaatgaa caagcacaaa
     7321 aagacattac tgagatccaa cgggcactaa cacttgatac gatcctgttt gtgcttacgg
     7381 caacaatcgc cctgtttatg attgtgcaat caagccattt gttgttcgca caacacaaaa
     7441 aacgctttct attgcggcgc cttttcggcc acagtctgtt tcgtgcttac cgtaatgtcc
     7501 tgttttggac gttggcaaca tgggtcgtca ttttaggcat tgccctttac cgccatagtg
     7561 ggacccaata cttggcgatc gtcgtacttg tccttttctt gacggaagtg gtggtcacgt
     7621 ctgttgtgtt aatgaggctc gagcagaaaa acaaagttag cgtattaaag ggggaataac
     7681 gaatggcagc tgcaatcgta gaactgactg acatcagcaa atcttttcat tcagaaacgg
     7741 tgctccgtga cttcaactta accattgatc gtggcgaaat gatcgcgatt acagggccaa
     7801 gcggctcagg aaagacaacg attttaaaca ttattggtct gttagaaaaa gaagatcgcg
     7861 gcacggtgcg gctttttggc aagaacaagc cagcatacca ttccaaacag gcattgcagt
     7921 tccgtaaaag caaaatcgct tacttgtttc aaaactttgc tttaatggat gatgaaacgg
     7981 tttcgaaaaa tctcgacgtc ccgctcgaac ttataaaggg atcacgtaca ttcaaacaac
     8041 aaaagaaaaa ggaagtgtta gaaaaagtcg gtctctttaa caaactaaat aaaaaagtcc
     8101 actcgctatc aggaggggaa caacaacgtg tggctattgc acgcctcttg ttacggccgt
     8161 gcgacttgtt gttagctgat gagccaacag gatcacttga tatggctaac cgcaatgtca
     8221 ttcttgattt gttatgccaa ttgaaccaag aaggaatgac gattgtgatc gttacccatg
     8281 atcctgaagt tgccgaccga tgcgatcggg taatcaccct ttaaggaaaa gtcactacag
     8341 ggattaacca tgcctttatg gcgttctcct atagaaatgc acgtttttat aggagaacgg
     8401 ttaagccggg aatatcaatg cagcacggta atcaagaacg atgctccatt aaagggcgcg
     8461 atatttttta cacagtcaat tctaagaagt tgccttcagg atcctctatc acactctcat
     8521 aatagccgtc cccagtaaca cgaggaccat taacaaggcg gtaaccgtca ttgtgtaagc
     8581 ggcctgtcat ctgattgacg gcctccttgc tccccagaga aatggcaata tgagcccaac
     8641 ccatccgatc gtcctgatcc ggcttatcga tacctgactg acacataatc tctaaacgtg
     8701 cacccccgtc aaacgttaga aagtaagatt caaatttctt atctttatta tgatactttg
     8761 agtttgcatg tccattaaag tacttaacat aaaatgtttt catagcttct aaatctttga
     8821 cccagattgc tacatgctct attttcatct cactgtcact cctctaatgt tgcactattt
     8881 ttaccttttt taaattcttg cggatgatta aatcatctca tcattcatgg atgaataggt
     8941 tacgagttaa aggaggagct cacttctcaa tactgtgatg gcttgcccta ataagaaaac
     9001 tctatcatgt tgcaatttga tttttaggat gcctcctctt ttagaagcct gataggcaag
     9061 aaattcgttt ttgtttaatt tttcttgcca gtatggacct agacaacaat gggctgaccc
     9121 tgtaacagga tcctcgttca cacctaccgc tggaaagaag catcttgaaa taaaatcgta
     9181 ttcagttgat gtcgatttgc ttgttacaat gattcctcta gtatcgattt gttctaatag
     9241 tgaaaaatta ggatttaatt cttttaacct ttgttcagag tctatttcaa ttaaataatc
     9301 aaatcggttt cggccaacat ataacggttg aatgcctaat ccatcaatca gttcattagg
     9361 atacacattt tcctgttttg gttgttcaga tgggaaatct aattcgatcc attcgccgcg
     9421 tttactagca gtaagtattc cgcttttagt ataaaatgta atgggctgtt ccgcgcttat
     9481 gtgatccagt tcccataaaa tacgggcact tgccagagtc gcatgtccac acaaatcgac
     9541 ctctgtattt ggtgtaaacc acctcaatga gtatccatct tgataagggt ggaggaaagc
     9601 agtctcggat aaattcattt ccgaagcaac atgctgcatc caaatatcat ctcgtgaagt
     9661 aggaagaaca cagacggctg ctggattccc tttaaaagct tgatttgtaa aagcgtctac
     9721 tacataaata ggggttgtca tcatctaaat tctccctctt acgattttta accactcttt
     9781 aaattttacc aaaagattaa acgaagcgga aaggcttttc cttccaaggt tgagaatgat
     9841 gtaaaatcga cagaagttaa ttagcaagat aagtgaatag aaggtttatt gagtattcca
     9901 gaactgggga ctatttgcta atgtgacgga ttgttaaccg aatgatttta tgatttaatt
     9961 gtagtgtagt aatacagttt aataggcttc ttaggtgcct catttgtagg agaataggga
    10021 agttttaaaa cgacgcggag cccgccactg tagtcgagga gctgctacaa taccactggg
    10081 aaactgggaa ggtgtagcat gcgatgaatc ggagccagga gacctgccta agaagatgcg
    10141 ctgtcattga tgaggcatgg cataccctca gcttatttaa gctggggttt tttgtgtggt
    10201 cgggagttac catcaaagga ggaaggatca tgcaaaaagt aaaggaaacg attggttcaa
    10261 tcaatgggtt ggacacaaaa gcacagcaac aaatggaaca acatttaaac actctgacga
    10321 aacctttggg gagtttaggt ttattagaat cattggcgat taaaat
//
