LOCUS       NZ_CP060274.1          10356 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP060274.1 Priestia flexa strain SSAI1 chromosome.
ACCESSION   NZ_CP060274
VERSION     NZ_CP060274.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 13:53:04
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 320279
            Orig. end    :: 330635
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10356
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[325279:325635]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5356
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10356
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10356
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="2"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             363..1148
                     /locus_tag="ctg1_323"
                     /transl_table=11
                     /translation="MFYFSMFFQYISQYIKTRLQYRADMVVEVVSDLLFQAVNLIFILV
                     VFGHTQFLNGWSREEIIFIYGFFLVPFAVFSSFFNIWDFNERYIVKGEMDRILTRPIHS
                     LFQVILERMELESLFGAITGVAVMIYAGSILDLLFAWYDFFVFILFVLGGALVYAGIFI
                     ALASIGFWSDARTSIMPTMYNIGNYGRYPVDIYNNVIRYVLTWILPFAFVGVYPAAYFL
                     GREEWYGYAFLTPVMGVIFFTLAIVLWNVGVKRYRGAGN"
     PFAM_domain     459..1142
                     /aSDomain="ABC2_membrane_6"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF06182.13"
                     /description="ABC-2 family transporter protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_323_0024"
                     /evalue="5.90E-52"
                     /label="ctg1_323"
                     /locus_tag="ctg1_323"
                     /protein_end="260"
                     /protein_start="32"
                     /score="176.8"
                     /tool="antismash"
                     /translation="LLFQAVNLIFILVVFGHTQFLNGWSREEIIFIYGFFLVPFAVFSS
                     FFNIWDFNERYIVKGEMDRILTRPIHSLFQVILERMELESLFGAITGVAVMIYAGSILD
                     LLFAWYDFFVFILFVLGGALVYAGIFIALASIGFWSDARTSIMPTMYNIGNYGRYPVDI
                     YNNVIRYVLTWILPFAFVGVYPAAYFLGREEWYGYAFLTPVMGVIFFTLAIVLWNVGVK
                     RYRGAG"
     CDS             1241..1642
                     /locus_tag="ctg1_324"
                     /transl_table=11
                     /translation="MTVSLILVIVFLMVGSMKFLFEKELGEFHFFSLGHFFVLLYSYLT
                     VLLGFSLIYTVCEMSNIEVISGGFYHQEHYFYTLFNSMYFSAITLFSVGYGDMYPVGIG
                     KMFATIEALIGYMMPAVFVIRTVSRNEKV"
     PFAM_domain     1373..1624
                     /aSDomain="Ion_trans_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07885.18"
                     /description="Ion channel"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_324_0025"
                     /evalue="5.00E-13"
                     /label="ctg1_324"
                     /locus_tag="ctg1_324"
                     /protein_end="128"
                     /protein_start="44"
                     /score="48.9"
                     /tool="antismash"
                     /translation="TVLLGFSLIYTVCEMSNIEVISGGFYHQEHYFYTLFNSMYFSAIT
                     LFSVGYGDMYPVGIGKMFATIEALIGYMMPAVFVIRTVS"
     CDS             1712..2182
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1196:alkyl hydroperoxide reductase/ Thiol specific
                     (Score: 191.1; E-value: 1.6e-58)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_325"
                     /transl_table=11
                     /translation="MTVTVGEVAPDFKLAANNGEEVALSDYKGQNVVLYFYPKDMTPGC
                     TTEACDFRDAHQEFADLDAVILGVSPDPIDKHQKFIDKHGLPFLLLADEDHQVAEAYGV
                     WKLKKNFGKEYMGIERSTFIINKDGEIAKEYRKVRVKDHVAEALRFIKENLA"
     PFAM_domain     1724..2107
                     /aSDomain="AhpC-TSA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00578.23"
                     /description="AhpC/TSA family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_325_0026"
                     /evalue="2.10E-42"
                     /label="ctg1_325"
                     /locus_tag="ctg1_325"
                     /protein_end="132"
                     /protein_start="4"
                     /score="144.0"
                     /tool="antismash"
                     /translation="VGEVAPDFKLAANNGEEVALSDYKGQNVVLYFYPKDMTPGCTTEA
                     CDFRDAHQEFADLDAVILGVSPDPIDKHQKFIDKHGLPFLLLADEDHQVAEAYGVWKLK
                     KNFGKEYMGIERSTFIINKDGEIA"
     CDS             2428..2862
                     /gene_functions="regulatory (smcogs) SMCOG1266:hydrogen
                     peroxide sensitive repressor (Score: 122.7; E-value:
                     1.7e-37)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_326"
                     /transl_table=11
                     /translation="VSKHLQEALEMLKETGVRITPQRHAILEYLINSMTHPTADDIYKA
                     LEDKFPNMSVATVYNNLRVFKEVGIVKELTYGDASSRFDYITTEHYHVICEKCGKIVDF
                     HYPGLDEVEALAAHITGFEISHHRMEIYGTCPDCTTKKAH"
     PFAM_domain     2467..2823
                     /aSDomain="FUR"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01475.21"
                     /description="Ferric uptake regulator family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_326_0027"
                     /evalue="1.40E-39"
                     /label="ctg1_326"
                     /locus_tag="ctg1_326"
                     /protein_end="132"
                     /protein_start="13"
                     /score="135.1"
                     /tool="antismash"
                     /translation="ETGVRITPQRHAILEYLINSMTHPTADDIYKALEDKFPNMSVATV
                     YNNLRVFKEVGIVKELTYGDASSRFDYITTEHYHVICEKCGKIVDFHYPGLDEVEALAA
                     HITGFEISHHRMEIY"
     CDS             complement(2874..3245)
                     /locus_tag="ctg1_327"
                     /transl_table=11
                     /translation="MGIKYSSKINKIRTFALSLIFIGFIVMYGGIFFKSSMWLMTIFML
                     LGLLCIIASTVVYFWIGMLSTKAVQVTCPTCNKHTKMLGRVDLCMYCNEPLTLDPALDG
                     KEFDEKYNRKDTKKADSIS"
     PFAM_domain     complement(2904..3236)
                     /aSDomain="DUF2614"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF11023.10"
                     /description="Zinc-ribbon containing domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_327_0028"
                     /evalue="3.50E-62"
                     /label="ctg1_327"
                     /locus_tag="ctg1_327"
                     /protein_end="114"
                     /protein_start="3"
                     /score="207.5"
                     /tool="antismash"
                     /translation="KYSSKINKIRTFALSLIFIGFIVMYGGIFFKSSMWLMTIFMLLGL
                     LCIIASTVVYFWIGMLSTKAVQVTCPTCNKHTKMLGRVDLCMYCNEPLTLDPALDGKEF
                     DEKYNRK"
     PFAM_domain     3466..3819
                     /aSDomain="NTF-like"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF14540.8"
                     /description="Nucleotidyltransferase-like"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_328_0029"
                     /evalue="3.30E-45"
                     /label="ctg1_328"
                     /locus_tag="ctg1_328"
                     /protein_end="118"
                     /protein_start="0"
                     /score="152.8"
                     /tool="antismash"
                     /translation="MEDILRPLYQERASKKETLGILLIEKRKTDSPVTDDLDAILFIIT
                     SNNEVPVFVKQYEYKEQRAALYIASEQQISEWIMMGTNRRTVDWVLNGKVLFDRNEYVA
                     NLKKRLLDFPREDR"
     CDS             3466..4335
                     /locus_tag="ctg1_328"
                     /transl_table=11
                     /translation="MEDILRPLYQERASKKETLGILLIEKRKTDSPVTDDLDAILFIIT
                     SNNEVPVFVKQYEYKEQRAALYIASEQQISEWIMMGTNRRTVDWVLNGKVLFDRNEYVA
                     NLKKRLLDFPREDRVKRIGIEFAKLIRRFKEGKDFYTSNHHLDAFNHVVHALHHLARLS
                     VLENGFYPEVTVWNQVKKIEPSIYRLYEELVGSQEEINKKLELLFLASELYVNKKVDIG
                     STHLLTIMSEKEEWTFNELISHQQVSPYAIDLGILLEFLIQKEIVVIHKVETKGKSLYH
                     RYYAINKG"
     PFAM_domain     4138..4320
                     /aSDomain="HTH_52"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF18576.3"
                     /description="Helix-turn-helix domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_328_0030"
                     /evalue="5.50E-26"
                     /label="ctg1_328"
                     /locus_tag="ctg1_328"
                     /protein_end="285"
                     /protein_start="224"
                     /score="90.7"
                     /tool="antismash"
                     /translation="HLLTIMSEKEEWTFNELISHQQVSPYAIDLGILLEFLIQKEIVVI
                     HKVETKGKSLYHRYYA"
     CDS             5001..5201
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03651"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_329"
                     /sec_met_domain="TIGR03651 (E-value: 3.5e-09, bitscore:
                     34.8, seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEVVAYIAGALGISEYWANVIVTAIEAGSTVLALISMFASFGLTS
                     ALILTAKSLLKKGAKKTAVAY"
     aSDomain        5016..5198
                     /aSDomain="TIGR03651"
                     /aSTool="tigrfam"
                     /description="circ_ocin_uber: circular bacteriocin,
                     circularin A/uberolysin family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_329_0006"
                     /evalue="3.70E-09"
                     /identifier="TIGR03651"
                     /label="ctg1_329"
                     /locus_tag="ctg1_329"
                     /protein_end="66"
                     /protein_start="5"
                     /score="34.8"
                     /tool="antismash"
                     /translation="YIAGALGISEYWANVIVTAIEAGSTVLALISMFASFGLTSALILT
                     AKSLLKKGAKKTAVAY"
     PFAM_domain     5022..5198
                     /aSDomain="Bacteriocin_IId"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09221.12"
                     /description="Bacteriocin class IId cyclical
                     uberolysin-like"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_329_0031"
                     /evalue="1.80E-06"
                     /label="ctg1_329"
                     /locus_tag="ctg1_329"
                     /protein_end="66"
                     /protein_start="7"
                     /score="28.2"
                     /tool="antismash"
                     /translation="AGALGISEYWANVIVTAIEAGSTVLALISMFASFGLTSALILTAK
                     SLLKKGAKKTAVAY"
     CDS             5234..5356
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03651"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_330"
                     /sec_met_domain="TIGR03651 (E-value: 9.8e-07, bitscore:
                     26.9, seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEVVAYIAGALGISEYWANVIVTAIEAGSTVLALCSLALD"
     CDS             6284..6568
                     /gene_functions="other (smcogs) SMCOG1164:transposase
                     IS3/IS911 family protein (Score: 66.6; E-value: 2.6e-20)"
                     /gene_kind="other"
                     /locus_tag="ctg1_331"
                     /transl_table=11
                     /translation="MAKRERRTFTEDFKQQMVQLYQNGKPRKEIIREYDLTPSSLDKWV
                     GQSQRSGSFKEKDNLTDEQKELIELRKRNKQLEMENDILKQAALILGRK"
     PFAM_domain     6293..6505
                     /aSDomain="HTH_Tnp_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01527.22"
                     /description="Transposase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_331_0032"
                     /evalue="2.00E-11"
                     /label="ctg1_331"
                     /locus_tag="ctg1_331"
                     /protein_end="74"
                     /protein_start="3"
                     /score="44.0"
                     /tool="antismash"
                     /translation="RERRTFTEDFKQQMVQLYQNGKPRKEIIREYDLTPSSLDKWVGQS
                     QRSGSFKEKDNLTDEQKELIELRKRN"
     CDS             6610..7404
                     /gene_functions="other (smcogs) SMCOG1026:transposase
                     (Score: 219.4; E-value: 8.6e-67)"
                     /gene_kind="other"
                     /locus_tag="ctg1_332"
                     /transl_table=11
                     /translation="MCKVLQIPRSVYYYEAKERRAEDPVVSDVVEIFHASRQNYGTRKI
                     KVELKKRGLIVSRRRIGRIMQEQGLVSSYTIAQFKPHAKSCNESEQKNELNREFAQEQE
                     MTAIVSDLTYVRVNQKWNYVCVFVDLFNREIVGFSTGPNKDALLVYRALASIKVDLNKI
                     QLFHTDRGNEFKNKLIDDALKTFNIQRSLSMKGCPYDNAVAEATFKIIKTEFVKGRHFN
                     SLAELTREFQDYVHWFNNIRIHGTLGYASPIDYKHRHLKKIV"
     PFAM_domain     6673..6831
                     /aSDomain="HTH_21"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13276.8"
                     /description="HTH-like domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_332_0033"
                     /evalue="6.40E-13"
                     /label="ctg1_332"
                     /locus_tag="ctg1_332"
                     /protein_end="74"
                     /protein_start="21"
                     /score="48.8"
                     /tool="antismash"
                     /translation="EDPVVSDVVEIFHASRQNYGTRKIKVELKKRGLIVSRRRIGRIMQ
                     EQGLVSSY"
     PFAM_domain     6919..7203
                     /aSDomain="rve"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00665.28"
                     /description="Integrase core domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_332_0034"
                     /evalue="2.90E-12"
                     /label="ctg1_332"
                     /locus_tag="ctg1_332"
                     /protein_end="198"
                     /protein_start="103"
                     /score="46.9"
                     /tool="antismash"
                     /translation="EMTAIVSDLTYVRVNQKWNYVCVFVDLFNREIVGFSTGPNKDALL
                     VYRALASIKVDLNKIQLFHTDRGNEFKNKLIDDALKTFNIQRSLSMKGCP"
     PFAM_domain     7222..7389
                     /aSDomain="rve_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13333.8"
                     /description="Integrase core domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_332_0035"
                     /evalue="4.90E-16"
                     /label="ctg1_332"
                     /locus_tag="ctg1_332"
                     /protein_end="260"
                     /protein_start="204"
                     /score="58.7"
                     /tool="antismash"
                     /translation="EATFKIIKTEFVKGRHFNSLAELTREFQDYVHWFNNIRIHGTLGY
                     ASPIDYKHRHL"
ORIGIN
        1 gtttttcaat tatctttagc tttattgtta atactcaaat taacttatta acgggaatta
       61 cgacattctt cttgtttaat aatgatggat taattcgtgc aaagcgcgtt atcatagatt
      121 tgttttcagg gcttttatta ccaattagct tttatcctct ttgggcacaa gatttaatgg
      181 ggtatcttcc ttttcaagca atcagctata ttccaagcat gatctttaca gaaggattta
      241 cgggaagtga agtggtaact gcattggtga cacagcttat ttggtcactg cttttattta
      301 ttcctatcgt ctttctatgg aatgttgcaa agaaaaagat ggtcatccaa ggagggtaag
      361 caatgtttta tttttctatg ttctttcaat acatcagtca atatataaaa accagacttc
      421 aataccgagc tgatatggtt gttgaagttg tatctgattt actatttcaa gcagtaaacc
      481 taatttttat tttagttgta tttggccaca ctcaatttct caacggttgg tcacgagaag
      541 aaatcatttt tatttatgga ttcttcctag ttccttttgc agtattctct tcattcttta
      601 acatttggga ttttaatgag cgctatattg ttaaaggtga aatggatcgt atcttaacaa
      661 gacctattca tagcttgttt caagtgattt tagaaagaat ggaattagag tctttatttg
      721 gagcaatcac cggggtggca gtgatgattt atgctggctc cattttagac cttttgtttg
      781 cttggtatga ctttttcgtc tttattctat ttgtgctcgg gggagcgttg gtatatgcag
      841 gtatctttat tgcactcgca agcataggtt tttggtcaga tgctcgtacg tctattatgc
      901 caacgatgta taacattgga aactatggac gctatcctgt tgatatttat aacaacgtta
      961 ttcgttatgt gctaacatgg attttaccgt ttgcctttgt tggagtatat ccagctgctt
     1021 acttcttagg aagagaagaa tggtatggct atgcattttt aactccagtt atgggggtta
     1081 tcttttttac tctagctatt gtcttatgga atgttggtgt aaaaaggtat cgaggagcag
     1141 gcaactgatg cctgcttttt ttatgctatt gaacagtaat gagtaggtag gggacaacgt
     1201 atagtaatac aagaactttt ttacttaaag gagtatccgt atgacggttt cgttgattct
     1261 agtcattgtg tttctaatgg taggaagcat gaaatttttg tttgaaaaag agctcggtga
     1321 atttcatttc ttctcacttg gtcatttttt tgttttactt tattcatatt taacggtttt
     1381 gcttggcttt agcttaatct atacggtttg tgaaatgagt aatatagaag taattagtgg
     1441 aggattttat catcaagaac attattttta tacactgttc aacagcatgt attttagtgc
     1501 cattacgcta ttctctgtag ggtatggaga tatgtatccc gttggtattg gaaagatgtt
     1561 tgcaacaatc gaagctctca ttgggtatat gatgccagct gtttttgtga ttcgcacggt
     1621 aagtcgaaat gagaaagttt aaaagttgtc ttaaatcgcg aaattggtta ccctataacc
     1681 atagagaact gtataaaagg agcgatataa gatgacagta acagtaggtg aagtagcacc
     1741 agattttaaa ctagcagcta acaatggaga agaggtagct ctatctgatt ataaaggtca
     1801 aaatgttgtt ctttattttt atccaaaaga tatgacgccg ggctgtacga cagaagcatg
     1861 tgatttcaga gatgctcatc aagaatttgc agacttagat gccgttatct taggcgtaag
     1921 tccagatcca attgataaac atcaaaaatt tattgataaa cacggactac catttttact
     1981 attagcagac gaagatcatc aagttgctga agcatatggt gtatggaagt taaaaaagaa
     2041 ctttggaaaa gagtatatgg gcattgagcg ctcgacgttc attattaaca aagacggtga
     2101 aattgcgaaa gaatatcgca aagtgcgtgt gaaagatcac gtagcagaag ctttacgttt
     2161 tattaaagaa aatttagcat aattaaggca ttcgtctata acaaaatctt tcgttatgcg
     2221 tatgataaca atgtagggca tacctcctca ggtgttacga tataaagcgc gacttagata
     2281 gtcgcgtttt ttttgaatga ataaaaaatc gtttaaaaat aatatatagt aggaattgtt
     2341 aatgagattg acaaagtgaa gcagtaagag ttacactaat tgtaagaatt ataaagtaag
     2401 aatgcttata gaagagaggt gcatgacgtg tcaaaacatt tacaagaagc gcttgaaatg
     2461 ctgaaagaaa ctggcgttcg cattacaccg caacgtcatg ctattttaga gtatttaatc
     2521 aattcaatga cacatccaac tgctgatgat atttataaag cattggagga taaatttcct
     2581 aatatgagtg tggcaaccgt ttataataat ctacgcgttt ttaaagaagt aggaattgta
     2641 aaagagctaa cttacggaga tgcttcaagt cgttttgatt atattacgac cgagcattac
     2701 cacgtaatat gcgaaaagtg tggaaaaatt gttgacttcc attatccagg attagatgaa
     2761 gtagaagcac ttgcagcgca cattaccggg tttgagatta gtcaccaccg tatggagatt
     2821 tatggtactt gtccggattg tacaactaaa aaagcacatt aaaaagctga tagttatgat
     2881 atactatcag ctttctttgt gtcttttcta ttatatttct catcaaactc ttttccatca
     2941 agggctggat ctagagtcaa aggctcattg cagtacatac ataagtctac tcgtccaagc
     3001 attttcgtat gtttattaca ggttgggcat gtgacctgta cagctttagt agaaagcatg
     3061 ccaatccaaa agtaaacaac ggtactagca atgatacata gtaaacccaa tagcataaaa
     3121 atggtcataa gccacatgga agatttaaaa aagattcctc catacatcac gatgaagcca
     3181 ataaaaatta aacttaatgc aaatgtcctg atcttattga ttttacttga gtatttaatt
     3241 cccatgaaaa atctccctcc cactttataa atatagcata attgtaagaa aaataagtct
     3301 tttaggttga attaactgat agaactgttt agggagtgaa taaaagagag aatttgttat
     3361 aataagctgt gaggaagtcc gtcacgaaca ttcacactaa atgtgtttca atataaaaga
     3421 agattagacc aatatcttta attatgatag tgaggagctt gcagaatgga agatatttta
     3481 cgaccgctat accaagagcg agcaagtaaa aaagaaacgt taggtatttt attaatagaa
     3541 aaaaggaaaa cagattcacc agttacagat gacttagatg ccatactatt tattatcaca
     3601 agtaacaatg aggtacctgt gtttgtgaag cagtatgagt ataaagaaca aagagcagct
     3661 ctttatatag cttcagaaca gcagattagc gaatggatta tgatgggtac caaccgacgt
     3721 actgttgatt gggtgttaaa tggaaaagta ctgtttgatc gtaatgaata cgtagcaaat
     3781 ttgaaaaaaa gactactgga ttttccgcgc gaagatcgag tgaagaggat aggtattgaa
     3841 tttgccaagc ttattcgccg ttttaaagaa ggaaaagact tttatacgtc aaatcatcat
     3901 ctagatgcat tcaatcatgt ggttcatgct ttacaccatt tagcgcgtct atcagtacta
     3961 gaaaatgggt tttacccaga ggttactgtt tggaatcaag tgaaaaaaat tgagccatct
     4021 atttatcgtt tatatgaaga gcttgttggc agccaagaag agataaacaa gaagcttgag
     4081 ctattattct tagctagtga gctttatgta aataaaaagg ttgatatagg ttctacacat
     4141 ctattaacaa ttatgagcga aaaagaagag tggacgttta atgaactcat ttcacatcag
     4201 caagttagcc catatgcaat cgatttagga attttgctag aattcctcat ccaaaaagag
     4261 attgtagtaa ttcataaagt ggagacaaaa ggaaagagtt tatatcatcg ttactacgct
     4321 attaataagg gttaataaag gaaagataaa aaaacaaatg tttttttatc tttttttaaa
     4381 aaagatgttg acgttcatga aaatacatgt taaatttata tacgtcgctg atgagcgata
     4441 ccaagtttat gaaaaacttg aaaaataatc ttaaaaaagt tgttgacaaa aagttaacta
     4501 cttggtaaga taagaaagtc gcttaagagc gacggttgaa ctttgaaaac tgaacaaagc
     4561 gacaaacgtc aacgttaatt ttttaaaact tttatgagca agtcaaacat ttcttcggag
     4621 agtttgatcc tggctcagga tgaacgctgg cggcgtgcct aannnnnnnn nnnnnnnnnn
     4681 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     4741 nnnnnnnnnn nnnnnnnnnn nnaaaacatg gaagtagtag catatatcgc aggagcatta
     4801 ggaatttctg aatactgggc aaacgtaatc gtaacagcaa tcgaagcagg cagcacagtt
     4861 ctagctttga tctcaatgtt cgctagcttt ggattaacat cagcactaat cttaacagct
     4921 aaatcattat tgaaaaaagg cgctaagaaa acggcagtag cttactaata aattaaaaat
     4981 tttaaaatga ggtgaaaaac atggaagtag tagcatatat cgcaggagca ttaggaattt
     5041 ctgaatactg ggcaaacgta atcgtaacag caatcgaagc aggcagcaca gttctagctt
     5101 tgatctcaat gttcgctagc tttggattaa catcagcact aatcttaaca gctaaatcat
     5161 tattgaaaaa aggcgctaag aaaacggcag tagcttacta ataaattaaa aattttaaaa
     5221 tgaggtggaa aacatggaag tagtagcata tatcgcagga gcattaggaa tttctgaata
     5281 ctgggcaaac gtaatcgtaa cagcaatcga agcaggcagc acagttctag ctttatgttc
     5341 gctagctttg gattaacatc agcactaatc ttaacagcta aatcattatt gaaaaaaggc
     5401 gctaagaaaa ctgcagttcc acagtagctc agtggtagag caatcggctg ttaaccgatc
     5461 ggtcgtaggt tcgagtccta cctgtggagc catttccaca gtagctcagt ggtagagcaa
     5521 tcggctgtta accgatcggt cgtaggttcg agtcctacct gtggagccat ttggagagct
     5581 gtccgagtgg ccgaaggagc acgattggaa atcgtgtagg cggttaacgc tgtctcaagg
     5641 gttcaaatcc cttgctctcc gccatttatt tcttaaatgg cccgttggtc aagtggttaa
     5701 gacaccgccc tttcacggcg gtaacacggg ttcgaatccc gtacgggtca ccataattct
     5761 tatacatagt tggaggatta gctcagctgg gagagcacct gccttacaag cagggggtcg
     5821 gcggttcgat cccgtcatcc tccaccnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     5881 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     5941 nnnnnncgaa cacggaagtt aagttctcta gcgccgatgg tagttgggac tttgtccctg
     6001 tgagagtagg acgttgccag gctttataag attccacagt agctcagtgg tagagcaatc
     6061 ggctgttaac cgatcggtcg taggttcgag tcctacctgt ggagccannn nnnnnnnnnn
     6121 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     6181 nnnnnnnnnn nnnnnnnnnn nnnnnnntgg ataggctaca cttagttgga cagaattttt
     6241 aaggtcaagt agactacaga taatacattt gaggagaatc tacatggcca aaagagaacg
     6301 ccgaacattt actgaagatt tcaagcaaca gatggtgcag ctataccaaa atggaaaacc
     6361 aagaaaagag attattcgtg aatatgacct aactccttcc tctttagata agtgggtggg
     6421 ccagagtcaa aggtcaggtt cttttaagga gaaagataat ttaacagatg aacaaaagga
     6481 attgatagaa ctccgaaaaa gaaataagca actagaaatg gaaaatgaca ttttaaagca
     6541 agccgcgctg atactaggac gaaagtaaat gtaattaaga ataaccaaca caaatactcg
     6601 atatcagcaa tgtgcaaagt cctacaaatc cctagaagcg tctattatta tgaagcaaaa
     6661 gaaagaagag cagaggatcc cgttgtctct gatgtggtcg aaatttttca cgcaagccgt
     6721 caaaattatg gaacacgaaa aatcaaagtt gaattgaaaa agcgtggtct tatcgtgtct
     6781 agacgaagaa ttggacgcat catgcaggag cagggccttg tttcttcata tacaatcgcc
     6841 caatttaaac cacatgcaaa atcgtgtaat gaatcagaac agaagaatga gctgaatcgt
     6901 gagttcgccc aggaacaaga aatgaccgca atcgtaagcg atttaacata cgtaagagtg
     6961 aatcaaaaat ggaactacgt atgtgtcttt gttgatctct ttaatcgaga aattgtgggt
     7021 tttagcacag gaccaaacaa agatgcatta ctcgtttatc gtgcattagc ttctatcaaa
     7081 gtcgatctta ataagataca gctttttcat acggatcgtg gaaatgaatt taaaaataaa
     7141 ctgattgatg atgctttaaa gacatttaat atccagcgat ccttaagtat gaagggctgc
     7201 ccatatgata atgcagtagc cgaagcgact tttaaaatta tcaaaacaga gtttgtgaaa
     7261 ggaagacatt ttaatagttt agcagaatta acgagggaat ttcaggacta tgttcactgg
     7321 tttaataaca tccgaattca tggaaccctt ggatatgcaa gcccaattga ttacaagcat
     7381 agacacctta agaaaattgt ctagtttagt gttgacatac cagtcccgtg gtgtagcggt
     7441 taacatgcct gcctgtcacg caggagatcg cgggttcgat tcccgtcggg accgccatta
     7501 taagaaggct cggtagctca gttggtagag caaaggactg aaaatccttg tgtcggcggt
     7561 tcgattccgt cccgagccac catcttatga aaacacgccg gtgtagctca actggtagag
     7621 caactgactt gtaatcagta ggttgggggt tcaagtcctc ttgccggcac catgtttttc
     7681 tggaggggta gcgaagtggc taaacgcggc ggactgtaaa tccgctcctt cgggttcggc
     7741 agttcgaatc tgcccccctc caccatctta taggggtata gtttaaaggt agaactacgg
     7801 tctccaaaac cgtcagtgtg ggttcgattc ctactacccc tgccaattaa tacggcgatt
     7861 gtggcgaagt ggttaacgca tcggattgtg gttccgacat tcgtgggttc gattcccatc
     7921 agtcgcccca tttttattgg gctatagcca agcggtaagg caacggactt tgactccgtc
     7981 atgcgttggt tcgaatccag ctagcccagc catacaatat gcggaagtag ttcagtggta
     8041 gaacaccacc ttgccaaggt gggggtcgcg agttcgaacc tcgtcttccg ctccatattt
     8101 tgaataaagt ggcggcatag ccaagtggta aggcagaggt ctgcaaaacc tttatcaccg
     8161 gttcaaatcc ggttgccgcc tccattattc acaataagtc ctgccggggt ggtggaattg
     8221 gcagacacac aggacttaaa atcctgcggt aggtgactac cgtgccggtt caagtccggc
     8281 cctcggcacc atttatatta tttctgcctt ttttattttg ccagtgtggc ggaattggca
     8341 gacgcgcacg actcaaaatc gtgttccttc gggagtgtcg gttcgacccc gaccactggt
     8401 attagtttta cataaaagaa cgtaatgtta agacttcaac agagatgttg aggtcttttt
     8461 tgtgtttagt cttttcaaag caactgatta agtttgaatt aaataaaaat tgtaaattag
     8521 ttaacaaaat gtaattcatc tctctagaag tcgagtgtga agaggtgtac aataagtact
     8581 aaagatgaaa gactcacgca gtaagcttct tagttcactg ctgaggtgat aagttagttt
     8641 gaaaggggat acatagtttt gaacgtaaat tatttagatc tactggctaa gaagtatgac
     8701 acagaagaga aagtggtaac ggaaattatt aacttagaag caattctaaa tttgccaaaa
     8761 ggaacagaac actttgtaag tgatttacac ggcgagtatc aggcctttca acacgtatta
     8821 cgaaatgggt cgggaaacgt aaaagaaaag attaaagatc tatttaagga tacattatct
     8881 caacaagaaa ttaatgaatt tgcgacgctt gtttattatc cagaagagaa gctgaagatt
     8941 attaaagcaa actttactcg caaacaagaa ctacgtgatt ggtatacgac aatgattaat
     9001 cgcatgcttg atttagtttt gtatgcatca tcgaagtata cacgttcaaa ggtgcgtaaa
     9061 gcactccctg agcagtttgc ttatattatt gaagagcttt tatataagac agatgaattt
     9121 acaaataaag agcattacta tcataaaatt gtgcagcaaa tcatttcatt aggacaagct
     9181 gataaactta tatcaggact ggcttatacc attcagcggt tggttgtcga tcatttgcat
     9241 gtcgttggag atatttatga tcgtggtcca gaacctgata aaatcatgga aactcttatt
     9301 aactatcatt ccgtcgatat tcagtgggga aaccatgacg ttctttggat tggagctttt
     9361 gcaggttcga aagtatgctt agctaatatt gttcgtattt gtgcacgtta taataactta
     9421 aatattattg aagatgcgta tggtattaac ttacgaccac ttctaaacct agcagaaaaa
     9481 tattatgatg ataatcctgc attccgtcca aaagaaaatg taggttcgca actatctgag
     9541 catgaacgtt tacagattac aaaaattcat caagctattg cgatgattca gtttaagctt
     9601 gaaatgccaa ttattaaaag acgtccgtat ttcaatatgt cagaacgact tttgcttgag
     9661 aaagttaatt atgaaacaaa tgaaattaca cttggagata aaacgtatcc tattgaaaat
     9721 ggatgctttg caacggtaaa ccctgaaaat ccacaagagc tcttagaaga agaggagcag
     9781 gttattgaga aattattgtt ttcagttcaa cattctgaaa agctagcaag acatatgaac
     9841 tttcttatga ataaaggaaa tctctatttg aaatacaatg ggaacttact catccatgga
     9901 tgcattcctt tagatgaaga aggaaatatg gaaaagatgg tgattgaagg caagttttat
     9961 tcaggtcgtc aactgttaga tgtgtttgag cagtatttgc gttcggcttt tgcaggcccg
    10021 gataaaacgg atgatttagc aactgacatg gtctggtatt tatggacggg cgaatattca
    10081 tctctatttg gaaaacgagc gatgacgacg tttgagcgct atttcattaa agataaagca
    10141 acgcataaag aaaagaaaaa tccatattat taccttcgtg aaaaagagga tatgtgccgt
    10201 cgaatattag ctgattttgg attaaatcca gatcatggtc atatcattaa tggtcacacg
    10261 cctgttaaag agatagaagg tgaaaaccct gttaaagcaa acggtagaat gattgtcatt
    10321 gatggcgggt tttcaaaagc atatcaatca caaacc
//
