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Overview
2.1

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_UGGM01000001 (original name was: NZ_UGGM01000001.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 2.1 | NRPS | 388,352 | 431,717 |

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 2.1 | NRPS | 388,352 | 431,717 |

No secondary metabolite regions were found in these records:
  NZ_UGGM01000002 (original name was: NZ_UGGM01000002.1)

Compact view
c00002_NZ_UGGM.. - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
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Location: 388,352 - 431,717 nt. (total: 43,366 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000460.1 |  | 0.29 | NRP | vulnibactin | Vibrio vulnificus CMCP6
BGC0001343.1 |  | 0.28 | Polyketide | aurachin A, aurachin D | Stigmatella aurantiaca Sg a15
BGC0000352.1 |  | 0.26 | NRP | fimsbactin A | Acinetobacter sp. ADP1
BGC0000373.1 |  | 0.26 | NRP | holomycin | Streptomyces clavuligerus ATCC 27064
BGC0000343.1 |  | 0.25 | NRP | enterobactin | Pseudomonas sp. J465
BGC0000662.1 |  | 0.24 | Terpene | grixazone | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001444.1 |  | 0.23 | Other | caboxamycin | Streptomyces sp. NTK 937
BGC0001538.1 |  | 0.23 | NRP, Polyketide | caboxamycin | Streptomyces sp. NTK 937
BGC0002000.1 |  | 0.22 | Polyketide | setomimycin | Streptomyces aurantiacus JA 4570
BGC0000225.1 |  | 0.22 | Polyketide | frenolicin B | Streptomyces roseofulvus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000460.1 |  | 0.62 | NRP | vulnibactin | Vibrio vulnificus CMCP6
BGC0001343.1 |  | 0.61 | Polyketide | aurachin A, aurachin D | Stigmatella aurantiaca Sg a15
BGC0000352.1 |  | 0.60 | NRP | fimsbactin A | Acinetobacter sp. ADP1
BGC0000373.1 |  | 0.60 | NRP | holomycin | Streptomyces clavuligerus ATCC 27064
BGC0000343.1 |  | 0.58 | NRP | enterobactin | Pseudomonas sp. J465
BGC0000662.1 |  | 0.57 | Terpene | grixazone | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001444.1 |  | 0.56 | Other | caboxamycin | Streptomyces sp. NTK 937
BGC0001538.1 |  | 0.56 | NRP, Polyketide | caboxamycin | Streptomyces sp. NTK 937
BGC0002000.1 |  | 0.55 | Polyketide | setomimycin | Streptomyces aurantiacus JA 4570
BGC0000225.1 |  | 0.55 | Polyketide | frenolicin B | Streptomyces roseofulvus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 388351 - 431717:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (cys)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg2_345: cys
  Search NORINE for peptide: strict or relaxed
  AMP-binding (458..867): cys
  NRPSPredictor2: cys
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      cys
    Small clusters prediction:
      cys
    Single AA prediction:
      cys
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DMFnvGvIWK
    Nearest Stachelhaus code:
      thr
    Stachelhaus code match:
      70% (weak)
ctg2_348: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (14..416): X
  NRPSPredictor2: hydrophobic-aliphatic
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      alpsLGVTFK
    Nearest Stachelhaus code:
      ile
    Stachelhaus code match:
      60% (weak)
ctg2_350: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (16..412): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      gfpYLGagCK
    Nearest Stachelhaus code:
      leu
    Stachelhaus code match:
      50% (weak)