LOCUS       NC_014376.1            18463 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NC_014376.1 [Clostridium] saccharolyticum WM1, complete sequence.
ACCESSION   NC_014376
VERSION     NC_014376.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 15:21:46
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 2082441
            Orig. end    :: 2100904
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..1353
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1143:sugar-binding lipoprotein (Score: 218; E-value:
                     4.6e-66)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_1906"
                     /transl_table=11
                     /translation="MRLKRVLAIVLAAGMACASLTACGSKTAESSAADTSGATTAADTT
                     KADDKKEGSGEKKVLSVTTWDYDSSPQFQAVVDAYMKENPNVEIKVIDTSADEYNNSLG
                     ISLSAAQPDPDIIWVKDMGSMLQMADKKQLLPLDDFMKKDSFDTSVYNGAAEQLQYNGV
                     TYGLPYRSDWYVLYYNKDLFDAAGVAYPSNDMTWDEYNELAAKMTSGEGSSKVYGGHNH
                     TWQALVTNWAVQDGKHTVVDKDYSFLKPWYESALSLQDNGYIQDYSTLKTANIHYSSVF
                     KNQQCAMMPMGTWFISTMIQSRASDETSFNWGIARIPHPADTETGYTVGALTPLGISAY
                     TDEPDLSWDFVKFATSKEAANILAEQGVFTGIQTEESLKTIASAQFFPEGESNIEALSY
                     THYSFDRPLDPQIEEIRKVLDEVHEMIMIKQYTVDQGIEELNKRVAEIKGW"
     protocluster    1..18463
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[2091238:2091808](+)"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      8798..9367
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
     cand_cluster    1..18463
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..18463
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="2"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     PFAM_domain     214..1080
                     /aSDomain="SBP_bac_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01547.27"
                     /description="Bacterial extracellular solute-binding
                     protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1906_0024"
                     /evalue="1.50E-31"
                     /label="ctg1_1906"
                     /locus_tag="ctg1_1906"
                     /protein_end="360"
                     /protein_start="71"
                     /score="110.6"
                     /tool="antismash"
                     /translation="QFQAVVDAYMKENPNVEIKVIDTSADEYNNSLGISLSAAQPDPDI
                     IWVKDMGSMLQMADKKQLLPLDDFMKKDSFDTSVYNGAAEQLQYNGVTYGLPYRSDWYV
                     LYYNKDLFDAAGVAYPSNDMTWDEYNELAAKMTSGEGSSKVYGGHNHTWQALVTNWAVQ
                     DGKHTVVDKDYSFLKPWYESALSLQDNGYIQDYSTLKTANIHYSSVFKNQQCAMMPMGT
                     WFISTMIQSRASDETSFNWGIARIPHPADTETGYTVGALTPLGISAYTDEPDLSWDFVK
                     FATSKEAA"
     CDS             1448..2365
                     /gene_functions="transport (smcogs) SMCOG1067:putative ABC
                     transporter permease protein (Score: 284.2; E-value:
                     1.8e-86)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_1907"
                     /transl_table=11
                     /translation="MKEVKKTLTSHQKKAIRSNLIGYSFILPNLIGYAIFVFIPVIFSF
                     ILSVMKWDGSQAPMEFVGLQNFAQIFSDRIFVQSFVHTIQYALLTVFPTLVFALLLAVL
                     LNHKLKGIAIFRTALYFPYIASIVAVGAVWNMLFQPDFGPINEFLKFIGISKPPRWVVD
                     VKWAMVAISVVSIWKYMGYYMIVYLAALQGISGSLYEAAGIDGANGFQKLRYITIPMLT
                     PTTFFVLIMLTIQCFKVFDLVYVMTGGGPGNATKTLVNYIYEKAFTTWQFGPASAGAIV
                     LFSVVLVITLIQFAGEKKWSKDLM"
     PFAM_domain     1730..2344
                     /aSDomain="BPD_transp_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00528.24"
                     /description="Binding-protein-dependent transport system
                     inner membrane component"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1907_0025"
                     /evalue="2.70E-13"
                     /label="ctg1_1907"
                     /locus_tag="ctg1_1907"
                     /protein_end="299"
                     /protein_start="94"
                     /score="50.2"
                     /tool="antismash"
                     /translation="LVFALLLAVLLNHKLKGIAIFRTALYFPYIASIVAVGAVWNMLFQ
                     PDFGPINEFLKFIGISKPPRWVVDVKWAMVAISVVSIWKYMGYYMIVYLAALQGISGSL
                     YEAAGIDGANGFQKLRYITIPMLTPTTFFVLIMLTIQCFKVFDLVYVMTGGGPGNATKT
                     LVNYIYEKAFTTWQFGPASAGAIVLFSVVLVITLIQFAGEKK"
     CDS             2378..3205
                     /gene_functions="transport (smcogs) SMCOG1069:putative ABC
                     transporter permease protein (Score: 283.7; E-value:
                     2.4e-86)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_1908"
                     /transl_table=11
                     /translation="MRTKTKDLKILLYLGLIALSLFMLVPFYWMVISSLKLNKDVFSIP
                     MKWWPDTMHWENYKIIWKKLPLVTFFFNTAKLTVITTIIQLCTSCFAAYGFTKTRFKGR
                     DFIFLMYVTTIAVPWQVYMVPQFILVSKLGLNDTHLGLILMQAFSAFGVFLIRQFYISI
                     PDELCEAARIDGLNEYGIFGKIVFPLGKPAMATLTIFTFTNVWNDFMGPLIYLKTKELK
                     TIQLGIRMFISQFGADYAWIMAASVCSLIPVIIVFLSCQKFFVEGVAASGIKG"
     PFAM_domain     2639..3172
                     /aSDomain="BPD_transp_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00528.24"
                     /description="Binding-protein-dependent transport system
                     inner membrane component"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1908_0026"
                     /evalue="9.20E-21"
                     /label="ctg1_1908"
                     /locus_tag="ctg1_1908"
                     /protein_end="265"
                     /protein_start="87"
                     /score="74.5"
                     /tool="antismash"
                     /translation="TSCFAAYGFTKTRFKGRDFIFLMYVTTIAVPWQVYMVPQFILVSK
                     LGLNDTHLGLILMQAFSAFGVFLIRQFYISIPDELCEAARIDGLNEYGIFGKIVFPLGK
                     PAMATLTIFTFTNVWNDFMGPLIYLKTKELKTIQLGIRMFISQFGADYAWIMAASVCSL
                     IPVIIVFLSCQKFFV"
     CDS             3331..4509
                     /locus_tag="ctg1_1909"
                     /transl_table=11
                     /translation="MAQTLEQIKTYPGMEESMVQQALDDAVAIVKKNLTKFTDKFQSSN
                     SFGGFYEETENVEWTTGFWTGVIWLAYEHTGDEAFRKAAEVQVESFLNRIENKIDVNHH
                     DMGFLYSLSCVAAYKLTGNEHAKKAALLAADHLAERYREKGRFLQAWGNPGEPKEYRLI
                     IDCLLNLPLLYWATEVTGDPSYEEKAENHIKTAMKCILRPDHSTYHTHFFDVETGDPTY
                     GVTHQGNRNGSAWARGQAWGIYGVALSYRYLKNTEYMDLFCSITDYFIKHLPEDLVPYW
                     DFDFDTGSTEPRDSSASAIAVCGILEMAKYLDKDKAMVYLDAADRMLRALVDHCANKNY
                     QKSNGLLLHGTYARDSKENTCTNRGVDECNTWGDYFYMEALTRLSGDWELYW"
     PFAM_domain     3436..4389
                     /aSDomain="Glyco_hydro_88"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07470.15"
                     /description="Glycosyl Hydrolase Family 88"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1909_0027"
                     /evalue="1.20E-29"
                     /label="ctg1_1909"
                     /locus_tag="ctg1_1909"
                     /protein_end="353"
                     /protein_start="35"
                     /score="103.5"
                     /tool="antismash"
                     /translation="KFTDKFQSSNSFGGFYEETENVEWTTGFWTGVIWLAYEHTGDEAF
                     RKAAEVQVESFLNRIENKIDVNHHDMGFLYSLSCVAAYKLTGNEHAKKAALLAADHLAE
                     RYREKGRFLQAWGNPGEPKEYRLIIDCLLNLPLLYWATEVTGDPSYEEKAENHIKTAMK
                     CILRPDHSTYHTHFFDVETGDPTYGVTHQGNRNGSAWARGQAWGIYGVALSYRYLKNTE
                     YMDLFCSITDYFIKHLPEDLVPYWDFDFDTGSTEPRDSSASAIAVCGILEMAKYLDKDK
                     AMVYLDAADRMLRALVDHCANKNYQKSNGLLLHGTYA"
     CDS             4540..5928
                     /locus_tag="ctg1_1910"
                     /transl_table=11
                     /translation="MKTNLLYVFADQWRYHAMGFMNMDQVVTPNIDSFAQESMRFTNAY
                     STYPLCSPHRASLMTGKYPFRAGMWTNCKIGLEEKVMLRPQEVCIGDILKTEGYLTGYI
                     GKWHLDASELNFTSSPKSGAKDWDAYTPPGERRHGFDYWLSYGAWDDHLDPHYWQDDER
                     QIKPGKWSAEFETDKAIEYMESRKDEDQPFALFLSYNPPHLPYELVPDRYYEKFKDLEI
                     QYRENVPEEMRQKGGLLETQTRQYYAAVYGIDEQFGRVLQYLKDHNMEENTIVILSADH
                     GEMLGSHGLMSKNIWYEESVHIPLMIRQKGRIKAVENNSIFASPDHMPTILELLEIPVP
                     KTCEGYGHSRGMFGTDENEPTNMLICSYPGSADMVKAFSDKGLSHKAYGWRGIKDKRFT
                     YVIFNGYAPGEGQMEYLYDNIADPYQLHPEILEPDCQRAEVLAYREALKNYLLQTEDPF
                     LWNR"
     PFAM_domain     4549..5547
                     /aSDomain="Sulfatase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00884.25"
                     /description="Sulfatase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1910_0028"
                     /evalue="7.20E-65"
                     /label="ctg1_1910"
                     /locus_tag="ctg1_1910"
                     /protein_end="336"
                     /protein_start="3"
                     /score="219.5"
                     /tool="antismash"
                     /translation="NLLYVFADQWRYHAMGFMNMDQVVTPNIDSFAQESMRFTNAYSTY
                     PLCSPHRASLMTGKYPFRAGMWTNCKIGLEEKVMLRPQEVCIGDILKTEGYLTGYIGKW
                     HLDASELNFTSSPKSGAKDWDAYTPPGERRHGFDYWLSYGAWDDHLDPHYWQDDERQIK
                     PGKWSAEFETDKAIEYMESRKDEDQPFALFLSYNPPHLPYELVPDRYYEKFKDLEIQYR
                     ENVPEEMRQKGGLLETQTRQYYAAVYGIDEQFGRVLQYLKDHNMEENTIVILSADHGEM
                     LGSHGLMSKNIWYEESVHIPLMIRQKGRIKAVENNSIFASPDHMPTILELLE"
     CDS             6031..6474
                     /locus_tag="ctg1_1911"
                     /transl_table=11
                     /translation="VLYFYGCICYNESALIKQGLNEVDDMSLKERANQLITDIPAIFLC
                     LKSRDTPLAAKILAGITVVYALSPVDLIPDFIPVLGYLDDVILLPVLIALTVKLIPQKL
                     FQQFKKEAKGMWENGKVKYWYYAIPIVAIWLLILWFFVKAIIF"
     PFAM_domain     6193..6300
                     /aSDomain="DUF1232"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF06803.14"
                     /description="Protein of unknown function (DUF1232)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1911_0029"
                     /evalue="3.90E-13"
                     /label="ctg1_1911"
                     /locus_tag="ctg1_1911"
                     /protein_end="90"
                     /protein_start="54"
                     /score="49.0"
                     /tool="antismash"
                     /translation="AKILAGITVVYALSPVDLIPDFIPVLGYLDDVILLP"
     CDS             complement(6546..7292)
                     /locus_tag="ctg1_1912"
                     /transl_table=11
                     /translation="MIHIYLCEDDTRQLNRWEDIISKYLLMNPTETKLYCATSKPEELL
                     SMRRRSGTTGLYFLDIDLQSNKNGIELAQEIRKYDPRGYVVFVTTHSEMAVLTFRYKVE
                     AMDFITKDDAETLPEQICSCIRNAERNYKVQLDASNRLLSIKVDKDSLVLDQNDIVAIT
                     TGDDSHKLTVHTRNGVRQISGSLKEYHTTLNSNFCQCNRSTIINLKHVTKYSRESALLL
                     MNNRETYSVSIRMMGKVQKALNNIHP"
     PFAM_domain     complement(6564..6839)
                     /aSDomain="LytTR"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04397.17"
                     /description="LytTr DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1912_0031"
                     /evalue="2.40E-15"
                     /label="ctg1_1912"
                     /locus_tag="ctg1_1912"
                     /protein_end="243"
                     /protein_start="151"
                     /score="56.6"
                     /tool="antismash"
                     /translation="LVLDQNDIVAITTGDDSHKLTVHTRNGVRQISGSLKEYHTTLNSN
                     FCQCNRSTIINLKHVTKYSRESALLLMNNRETYSVSIRMMGKVQKAL"
     PFAM_domain     complement(6933..7283)
                     /aSDomain="Response_reg"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00072.26"
                     /description="Response regulator receiver domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1912_0030"
                     /evalue="3.80E-13"
                     /label="ctg1_1912"
                     /locus_tag="ctg1_1912"
                     /protein_end="120"
                     /protein_start="3"
                     /score="49.7"
                     /tool="antismash"
                     /translation="IYLCEDDTRQLNRWEDIISKYLLMNPTETKLYCATSKPEELLSMR
                     RRSGTTGLYFLDIDLQSNKNGIELAQEIRKYDPRGYVVFVTTHSEMAVLTFRYKVEAMD
                     FITKDDAETLPEQ"
     CDS             complement(7304..8617)
                     /locus_tag="ctg1_1913"
                     /transl_table=11
                     /translation="MIYFIYTLTGALCVYFFCVHLLPNKLTILKRVIIFLYAFSTIFLF
                     NRIFGQASTFITFLGIILLIYFFTNNQYLSLSCYLFGYLYTITFNYLFMWIAGFIFKMD
                     MEALLTHHLLLVTFSCVYCMFCGTTTKLIGYYFHKKLNIAKYLTNNHLLKAIFIDLFLL
                     VFFYIFNFSYGERLGYNYGVIAINGIIFLLLFLITVFLMYSVYKVTMGEQAYKHRMAQF
                     ENLRVYTKRLEKSYGIMRKFKHDYMNILITMSGFLKENDMDGLKEYYGERILPISRAFT
                     ESDTKLGNLSNIKNTALKSLLSSKFVYMMEIGIKAEIELTEPINALNMDCLDLSRILGI
                     FLDNAMEAAMETEEKEVRFCMFYKGRDLYLIIQNTALPPTYAISELRSHDISTKGENRG
                     IGLFNVDVILKSYENAIWNTTYEEPYFTQELILIHNGS"
     PFAM_domain     complement(7322..7633)
                     /aSDomain="HATPase_c_5"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF14501.8"
                     /description="GHKL domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1913_0032"
                     /evalue="2.90E-21"
                     /label="ctg1_1913"
                     /locus_tag="ctg1_1913"
                     /protein_end="432"
                     /protein_start="328"
                     /score="75.3"
                     /tool="antismash"
                     /translation="MDCLDLSRILGIFLDNAMEAAMETEEKEVRFCMFYKGRDLYLIIQ
                     NTALPPTYAISELRSHDISTKGENRGIGLFNVDVILKSYENAIWNTTYEEPYFTQELIL
                     "
     CDS             8798..9367
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_1914"
                     /sec_met_domain="AgrB (E-value: 4.8e-30, bitscore: 102.2,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSITRIAVGFCGWLNKISPRSQEENKVIQYGMELLLDNVIKLIVI
                     SLIGIFLGKGLETFVVLAAFCGLRLQAGGIHAKTGFGCGFSMLVVWAISILGDMFFGIR
                     ASFLPYIYAVSVLVILCCAPRSINIEHFSVHDKLKKKIYSITILTLIMTIAFLNPSFRE
                     LLVYPVSLEVLTLLPKNKINVERENE"
     PFAM_domain     8858..9319
                     /aSDomain="AgrB"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04647.17"
                     /description="Accessory gene regulator B"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1914_0033"
                     /evalue="1.80E-29"
                     /label="ctg1_1914"
                     /locus_tag="ctg1_1914"
                     /protein_end="174"
                     /protein_start="20"
                     /score="102.5"
                     /tool="antismash"
                     /translation="SQEENKVIQYGMELLLDNVIKLIVISLIGIFLGKGLETFVVLAAF
                     CGLRLQAGGIHAKTGFGCGFSMLVVWAISILGDMFFGIRASFLPYIYAVSVLVILCCAP
                     RSINIEHFSVHDKLKKKIYSITILTLIMTIAFLNPSFRELLVYPVSLEVL"
     CDS             9364..9510
                     /locus_tag="ctg1_1915"
                     /transl_table=11
                     /translation="MMKKMAVEELQKMLVKVSLNSVGKSIPAAIYERKIPDAVLKMHNE
                     NAK"
     CDS             9905..10096
                     /locus_tag="ctg1_1916"
                     /transl_table=11
                     /translation="MIKKLYQRILILDYNIADVFVHKNIMSKRRKRKIIPDEYFIDVTA
                     TIPERKVVVENIIFNQCE"
     CDS             complement(10480..11118)
                     /locus_tag="ctg1_1917"
                     /transl_table=11
                     /translation="MTYFIYTFTGAICHYFFCIYLLPDKLTFIKQLVVFSYTFIIFFLF
                     GRIYGQASTFITFGGNILLIYFFTDNRYLSLSCYLFGYLYAITFNYLFLLLVGFIFKID
                     IEALITRNLLLIIFSCIYCMFCGTSLKLIAYYIHKKLNIAKYLTNRDLLKTIFVYLLLL
                     VFFCIFNFSYGERLGYTHDVIALNGIIFLMLFLITVFLMYSVYKILSAK"
     CDS             complement(11710..14166)
                     /locus_tag="ctg1_1918"
                     /transl_table=11
                     /translation="MTHNTTILNSVREQTLQILESGDIDGHGVDAYTLAIDLKMDRANV
                     SRALNDLWRDGLLIKFQGKPTLFLDRKLVTEYQPGFFIPQTVAKGEVLSNLIKASDNRK
                     QSDRAIFLEELIGADTSLKDIIALAKASVSYPPYGLHTLLFGSIGVGKSKFAHCMYLYK
                     KTLASTDSAIPFIPVTCHSFSDNPKLFSQQLLGLARDVVSNKSRRGFLDAAKGGILFFD
                     GIEHLSPASLELITSVITKNYYNRIGDTSLRDLQCMIIASTTCKSSNDPIRILAERFPS
                     AISIPDLEVRGIHEKIELIIQLFSEEARIIHLPIKISKDAISCMANMNYTRNIIQLMNE
                     IKTACSRAYLDSLSNHCRTVYIHLHDLSQELLSFIDCSANKQELVRHILEEIPDQYIEL
                     DQNGGSKYLNSFKSAPSTSEASHQQLLENHLSMEIESIDNIYQTVVENIARLSNCRDTE
                     LHAIKRNIYPIVFQIVIAQLQKKGKFEESKKHIHLLYGILLHITNFLKREDSHLLPDPC
                     EAPAASLDSFPEEYQMALDIMENLSQIYSCYFSNREIDYLASYFAIFSNWITTVNLGLL
                     VICHGETIASDMVSYALKTIYDDYIIDYINFSSTMSLKECLDLAVEKAKQLNRGSGILI
                     FTDMEPLTTINEYITRQTGIDTNILYPVTLPLLLETIRQILSNRSDFSLLTPASQTHSS
                     RAANLSSQEAFIQNLVDKVISKTTVFLDTTKAVNVLEKCLKATLLDLKIPYSNEIAAKY
                     LCHCCNMLERAIRGETWSYTRLNGFTNEHHELMYTVEHKLEYAENIFGIKIPASEIAYI
                     TEIFME"
     PFAM_domain     complement(11719..11964)
                     /aSDomain="PRD"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00874.22"
                     /description="PRD domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1918_0037"
                     /evalue="2.00E-06"
                     /label="ctg1_1918"
                     /locus_tag="ctg1_1918"
                     /protein_end="816"
                     /protein_start="734"
                     /score="28.1"
                     /tool="antismash"
                     /translation="KATLLDLKIPYSNEIAAKYLCHCCNMLERAIRGETWSYTRLNGFT
                     NEHHELMYTVEHKLEYAENIFGIKIPASEIAYITEIF"
     PFAM_domain     complement(12145..12447)
                     /aSDomain="EIIA-man"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03610.18"
                     /description="PTS system fructose IIA component"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1918_0036"
                     /evalue="2.50E-06"
                     /label="ctg1_1918"
                     /locus_tag="ctg1_1918"
                     /protein_end="674"
                     /protein_start="573"
                     /score="27.7"
                     /tool="antismash"
                     /translation="GLLVICHGETIASDMVSYALKTIYDDYIIDYINFSSTMSLKECLD
                     LAVEKAKQLNRGSGILIFTDMEPLTTINEYITRQTGIDTNILYPVTLPLLLETIRQ"
     PFAM_domain     complement(12484..12702)
                     /aSDomain="PRD"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00874.22"
                     /description="PRD domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1918_0035"
                     /evalue="1.30E-04"
                     /label="ctg1_1918"
                     /locus_tag="ctg1_1918"
                     /protein_end="561"
                     /protein_start="488"
                     /score="22.3"
                     /tool="antismash"
                     /translation="KHIHLLYGILLHITNFLKREDSHLLPDPCEAPAASLDSFPEEYQM
                     ALDIMENLSQIYSCYFSNREIDYLASYF"
     PFAM_domain     complement(13369..13824)
                     /aSDomain="Sigma54_activat"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00158.28"
                     /description="Sigma-54 interaction domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1918_0034"
                     /evalue="1.10E-19"
                     /label="ctg1_1918"
                     /locus_tag="ctg1_1918"
                     /protein_end="266"
                     /protein_start="114"
                     /score="70.8"
                     /tool="antismash"
                     /translation="LIGADTSLKDIIALAKASVSYPPYGLHTLLFGSIGVGKSKFAHCM
                     YLYKKTLASTDSAIPFIPVTCHSFSDNPKLFSQQLLGLARDVVSNKSRRGFLDAAKGGI
                     LFFDGIEHLSPASLELITSVITKNYYNRIGDTSLRDLQCMIIASTTCK"
     CDS             14452..14850
                     /locus_tag="ctg1_1919"
                     /transl_table=11
                     /translation="MSKVLLLSHGDLAREIWATSNMVLGEMSGVEYLTLPLGTDLNRYE
                     QDIRRKIEDAEDGLLILTDIFGGTPFITASRVFASLEDKDRVEIVTGMNLAMAIQVFNF
                     VGNMPVKELKKIAVTAGTEGIVDLKERI"
     PFAM_domain     14461..14796
                     /aSDomain="EIIA-man"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03610.18"
                     /description="PTS system fructose IIA component"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1919_0038"
                     /evalue="2.30E-19"
                     /label="ctg1_1919"
                     /locus_tag="ctg1_1919"
                     /protein_end="115"
                     /protein_start="3"
                     /score="69.7"
                     /tool="antismash"
                     /translation="VLLLSHGDLAREIWATSNMVLGEMSGVEYLTLPLGTDLNRYEQDI
                     RRKIEDAEDGLLILTDIFGGTPFITASRVFASLEDKDRVEIVTGMNLAMAIQVFNFVGN
                     MPVKELKK"
     CDS             14872..15339
                     /locus_tag="ctg1_1920"
                     /transl_table=11
                     /translation="MSVRMIRIDDRLIHGQIVAAWAKNLSIKRIWIVDDDVAKDAFITN
                     VMKMVSPPDTELVITGTDKAREMAEEFDAADKNTLILVKYPKVARLLFDTDIRLRELNV
                     GGMGANAERKKLFKNISASEEERKTLKDMKESGVKVYFQVTPNEKQTLFEG"
     PFAM_domain     14881..15318
                     /aSDomain="PTSIIB_sorb"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03830.17"
                     /description="PTS system sorbose subfamily IIB component"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1920_0039"
                     /evalue="6.50E-45"
                     /label="ctg1_1920"
                     /locus_tag="ctg1_1920"
                     /protein_end="149"
                     /protein_start="3"
                     /score="153.1"
                     /tool="antismash"
                     /translation="RMIRIDDRLIHGQIVAAWAKNLSIKRIWIVDDDVAKDAFITNVMK
                     MVSPPDTELVITGTDKAREMAEEFDAADKNTLILVKYPKVARLLFDTDIRLRELNVGGM
                     GANAERKKLFKNISASEEERKTLKDMKESGVKVYFQVTPNEK"
     CDS             15360..16112
                     /locus_tag="ctg1_1921"
                     /transl_table=11
                     /translation="MLIQSILVAFWAWFNGMVVSEYLVWIVRGAPLVSGTITGILMGDW
                     RSGAMIGATIQLLYMGQVTVGGISSYDKSYAGIIATAVTIASHQTPEIGITLAVALGTL
                     GLIASNIFMTVCVAFVHMADKYVEEGKTNRIWIYNWLLPNLLCGLLWGIPAFLAVYFGS
                     SYLEAFMNHIPAFVSKALTTVGMILPALGIAMMLKTVFNPRFSPFIVVGFLCVAYLHMD
                     IIACALLGGACAVLYWTLNLDKLTEGGN"
     PFAM_domain     15363..16064
                     /aSDomain="EII-Sor"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03609.16"
                     /description="PTS system sorbose-specific iic component"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1921_0040"
                     /evalue="8.70E-69"
                     /label="ctg1_1921"
                     /locus_tag="ctg1_1921"
                     /protein_end="235"
                     /protein_start="1"
                     /score="231.6"
                     /tool="antismash"
                     /translation="LIQSILVAFWAWFNGMVVSEYLVWIVRGAPLVSGTITGILMGDWR
                     SGAMIGATIQLLYMGQVTVGGISSYDKSYAGIIATAVTIASHQTPEIGITLAVALGTLG
                     LIASNIFMTVCVAFVHMADKYVEEGKTNRIWIYNWLLPNLLCGLLWGIPAFLAVYFGSS
                     YLEAFMNHIPAFVSKALTTVGMILPALGIAMMLKTVFNPRFSPFIVVGFLCVAYLHMDI
                     IACALLGGACAV"
     CDS             16115..16954
                     /locus_tag="ctg1_1922"
                     /transl_table=11
                     /translation="MDETIVAANENNEKKLRKSDLLRCFLIWETTSESCLSYERLMSLG
                     FCHAMTPVINRLYKTKEERASALKRHMVFFNTENNWGAFIPGIVCSMEEERANEGTISD
                     EMINSVKIGLMGPLAGIGDTITQGLFKTVLLAIFVDMTLKGNIAAPFIYAILMGAYIGG
                     LGYFTFFSGYRLGQNVLGKITDVAIMRKITNSLSILGLIIAGAMMVNNVSIVTPLAINI
                     GKTSVVIQDLLDSILPGMLSVIFVMLCFGLMKKRVSVFKIMIILFAVAIIAALFGIL"
     PFAM_domain     16157..16951
                     /aSDomain="EIID-AGA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03613.16"
                     /description="PTS system mannose/fructose/sorbose family
                     IID component"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1922_0041"
                     /evalue="6.30E-88"
                     /label="ctg1_1922"
                     /locus_tag="ctg1_1922"
                     /protein_end="279"
                     /protein_start="14"
                     /score="294.5"
                     /tool="antismash"
                     /translation="KLRKSDLLRCFLIWETTSESCLSYERLMSLGFCHAMTPVINRLYK
                     TKEERASALKRHMVFFNTENNWGAFIPGIVCSMEEERANEGTISDEMINSVKIGLMGPL
                     AGIGDTITQGLFKTVLLAIFVDMTLKGNIAAPFIYAILMGAYIGGLGYFTFFSGYRLGQ
                     NVLGKITDVAIMRKITNSLSILGLIIAGAMMVNNVSIVTPLAINIGKTSVVIQDLLDSI
                     LPGMLSVIFVMLCFGLMKKRVSVFKIMIILFAVAIIAALFGIL"
     CDS             17142..17960
                     /locus_tag="ctg1_1923"
                     /transl_table=11
                     /translation="MRKTWLSDVIGTEKAAFGLVHLLALPGDPLYDAEGGLERIYEAAL
                     SDVQSLQEGGIDALHFSNEFSFPYQKNPPREIMAAMAYIIGRLKPYIKVPYGANVISSP
                     SDSVALCASVGAKFTRGTFSGVYSGNLGLYDTAIGDYVRLRHNLHADDVKMIHYVVPES
                     SADIGGRDPLASAAASKFMNMPDGFAVPGATAGQSADMSLLHQLRKSMPDMVLVASTGV
                     KYETVEEIFSICDAAFIATSLKKDGIFENPVDKDRVKRFMERLKDFRNSL"
     PFAM_domain     17175..17939
                     /aSDomain="BtpA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03437.17"
                     /description="BtpA family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1923_0042"
                     /evalue="5.30E-57"
                     /label="ctg1_1923"
                     /locus_tag="ctg1_1923"
                     /protein_end="266"
                     /protein_start="11"
                     /score="193.3"
                     /tool="antismash"
                     /translation="TEKAAFGLVHLLALPGDPLYDAEGGLERIYEAALSDVQSLQEGGI
                     DALHFSNEFSFPYQKNPPREIMAAMAYIIGRLKPYIKVPYGANVISSPSDSVALCASVG
                     AKFTRGTFSGVYSGNLGLYDTAIGDYVRLRHNLHADDVKMIHYVVPESSADIGGRDPLA
                     SAAASKFMNMPDGFAVPGATAGQSADMSLLHQLRKSMPDMVLVASTGVKYETVEEIFSI
                     CDAAFIATSLKKDGIFENPVDKDRVKRFMERLK"
     aSDomain        17178..17942
                     /aSDomain="TIGR00259"
                     /aSTool="tigrfam"
                     /description="thylakoid_BtpA: membrane complex biogenesis
                     protein, BtpA family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1923_0015"
                     /evalue="7.50E-62"
                     /identifier="TIGR00259"
                     /label="ctg1_1923"
                     /locus_tag="ctg1_1923"
                     /protein_end="267"
                     /protein_start="12"
                     /score="207.1"
                     /tool="antismash"
                     /translation="EKAAFGLVHLLALPGDPLYDAEGGLERIYEAALSDVQSLQEGGID
                     ALHFSNEFSFPYQKNPPREIMAAMAYIIGRLKPYIKVPYGANVISSPSDSVALCASVGA
                     KFTRGTFSGVYSGNLGLYDTAIGDYVRLRHNLHADDVKMIHYVVPESSADIGGRDPLAS
                     AAASKFMNMPDGFAVPGATAGQSADMSLLHQLRKSMPDMVLVASTGVKYETVEEIFSIC
                     DAAFIATSLKKDGIFENPVDKDRVKRFMERLKD"
     CDS             17972..18463
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115:HAD-superfamily hydrolase, subfamily IA, variant
                     (Score: 71.6; E-value: 1.3e-21)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_1924"
                     /transl_table=11
                     /translation="MLKAVLFDCDGVLMDSESIYLSCVSQILGTLGKLASVEELAYLIG
                     ADIHVITERLKQDFGLENYDTEELIRVQRTLFNERFYREKLTPMDGLEGFLESLKKEGI
                     LLAVVSSSGQDYVEYVLDRLRIREYFNLYRRQPAVPSPSQTCTWRQSGGWESTQMRRWW
                     "
     PFAM_domain     17984..18364
                     /aSDomain="HAD_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13419.8"
                     /description="Haloacid dehalogenase-like hydrolase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1924_0043"
                     /evalue="1.60E-17"
                     /label="ctg1_1924"
                     /locus_tag="ctg1_1924"
                     /protein_end="131"
                     /protein_start="4"
                     /score="64.2"
                     /tool="antismash"
                     /translation="VLFDCDGVLMDSESIYLSCVSQILGTLGKLASVEELAYLIGADIH
                     VITERLKQDFGLENYDTEELIRVQRTLFNERFYREKLTPMDGLEGFLESLKKEGILLAV
                     VSSSGQDYVEYVLDRLRIREYFN"
ORIGIN
        1 atgagattaa aacgggtttt agctattgtt ttagcagctg gtatggcttg cgcatctctt
       61 acagcatgcg gcagcaagac tgcagaaagc agtgctgcag atacatctgg agcaacaact
      121 gctgcagata caacaaaggc agacgataaa aaagaaggct caggtgagaa gaaggttctt
      181 tccgttacca catgggacta tgattcatca cctcagttcc aggcagtcgt tgacgcttat
      241 atgaaagaga atccaaatgt agagatcaag gttattgaca catcggccga tgagtataac
      301 aattccttgg gaatcagctt atctgctgca cagccggatc cggatatcat ctgggtaaag
      361 gacatgggct ccatgcttca gatggcagat aagaagcagc ttcttcctct ggatgatttc
      421 atgaagaagg acagctttga tacatctgtt tacaacggtg cggctgaaca gcttcagtac
      481 aatggagtta cctatggact tccatatcgt tccgactggt atgttctgta ttataataag
      541 gatctttttg atgccgcagg cgttgcttat ccttccaatg acatgacctg ggatgagtat
      601 aatgaactgg cagctaagat gacctctgga gaaggcagct caaaggtata tggaggacat
      661 aatcatacct ggcaggcgct tgtaacaaac tgggccgtac aggatggcaa gcacacagtt
      721 gttgataagg attattcctt cttaaagcca tggtatgaat cagctctttc cttacaggat
      781 aatggatata ttcaggatta ctctacttta aagacagcaa atatccatta ctcttccgta
      841 tttaaaaatc agcagtgcgc tatgatgcct atgggaacct ggtttatttc aaccatgatc
      901 cagtcccgtg catcagatga aacatccttt aactggggca ttgcaaggat tcctcatccg
      961 gctgatacag aaaccggtta tacggtagga gctcttacac cccttggtat cagtgcttac
     1021 actgatgaac ctgacttatc ctgggatttc gtgaagttcg caaccagcaa agaggcagca
     1081 aatatcctgg ctgaacaggg cgtatttacc ggtatccaga cagaggaatc cttaaagacc
     1141 atcgcttccg cacagttttt cccggaagga gagtcaaata ttgaagcact gtcttatacc
     1201 cattactcat ttgaccgtcc tttagatcca cagatcgaag agattcgtaa agtactggat
     1261 gaagttcatg aaatgatcat gattaagcag tataccgttg atcaggggat tgaagaactg
     1321 aacaaacgag ttgcggaaat caaaggctgg taaaatataa ttgattgccc ggagagcgcc
     1381 ttttctaaaa acacagcaag gcgctctttt tgtggcaaaa agcaggtgaa aaggaggtaa
     1441 atcctgtatg aaggaagtta aaaagacact gacgtcacat cagaagaagg caatccgaag
     1501 taacctgatc ggttattcct ttattctgcc caatttaatc gggtacgcaa ttttcgtatt
     1561 cattcccgtg atcttttctt ttattttaag tgttatgaag tgggatggct ctcaggctcc
     1621 catggagttc gtaggattac aaaattttgc tcagattttt agtgacagga tatttgttca
     1681 atcgtttgtt cacaccattc aatatgcact gcttacggta ttcccgacct tggtgtttgc
     1741 acttttactg gcagttctct tgaatcataa actgaaggga atcgcaattt tccgtactgc
     1801 gctgtatttc ccatacattg cttctattgt agcagttggt gcagtgtgga atatgctgtt
     1861 tcagccggat tttggaccaa tcaatgaatt tttaaaattc atcggaattt ccaagccccc
     1921 cagatgggtc gttgatgtga aatgggctat ggtggccatt tccgtggtaa gtatatggaa
     1981 atatatggga tactatatga tcgtgtatct ggcagccctt cagggaatct ctggttctct
     2041 ttatgaagct gcaggtattg acggggccaa cgggtttcag aagcttcggt acattaccat
     2101 tcccatgctg acaccaacca cattcttcgt tttgatcatg ctgaccatcc agtgctttaa
     2161 ggtatttgac cttgtatatg taatgacagg cggaggtccg ggcaatgcca ccaaaactct
     2221 ggtcaattat atttatgaaa aagcatttac cacatggcag ttcggaccgg caagcgcggg
     2281 agctattgtt ctgttttccg tagtacttgt gatcaccctg atccagtttg caggtgaaaa
     2341 gaagtggtct aaggatttga tgtaaggagg gaaagcgatg agaacaaaaa caaaggattt
     2401 aaagatactt ctgtatctgg gattgattgc tttatccctt ttcatgctgg tgccctttta
     2461 ctggatggta atttcttctt taaagcttaa taaagatgta ttttccatac caatgaaatg
     2521 gtggccggat acgatgcatt gggagaacta caagatcatc tggaagaagc tgccactagt
     2581 gaccttcttt ttcaataccg ccaagctgac ggtcatcacg accattattc agttgtgcac
     2641 cagctgtttt gctgcttacg gtttcacaaa gacgcgtttt aaaggcaggg atttcatctt
     2701 ccttatgtat gttaccacca tagccgttcc atggcaggta tacatggttc cccagtttat
     2761 tctggtttcc aagcttggcc ttaacgacac tcatttagga ctgatcctga tgcaggcctt
     2821 ttccgcattc ggcgtgtttt tgatccgtca gttttatatc agtatcccgg atgaattatg
     2881 tgaagcagcc aggatcgatg gattaaatga gtacggaata tttggaaaaa tcgtgtttcc
     2941 tcttggtaag cctgcaatgg caacattgac catctttacg ttcaccaatg tatggaatga
     3001 tttcatggga ccattgatct acttaaagac taaggaatta aaaacgatcc agttgggtat
     3061 ccggatgttt atatcccagt tcggagcgga ttacgcatgg atcatggctg cttctgtttg
     3121 ttccctgatc ccggtcatta ttgtgttttt aagctgccag aagttctttg ttgagggcgt
     3181 tgcagccagt ggaatcaagg gttaaccgga aacagaaagg aatacctgca ggaatacctt
     3241 gatgtcccca atatggacat aggaggaaat accctggggg taagccgata tgttctgaaa
     3301 tatggacaat agtaggaaag gggatgcatt atggcacaga cattggaaca aataaaaacc
     3361 tatcctggaa tggaagagag tatggtacaa caggctcttg atgatgcggt agcgattgtt
     3421 aaaaaaaacc ttacgaaatt tacagataaa ttccagtctt ccaacagttt cggcggattt
     3481 tatgaggaaa cagaaaatgt ggaatggacg acaggatttt ggacaggagt gatctggctg
     3541 gcatacgagc ataccggtga tgaagcattc cggaaagccg cagaagtaca ggtggaaagt
     3601 ttccttaaca gaattgaaaa taaaattgat gtaaaccacc atgacatggg atttttatac
     3661 agcttgtcct gcgtagcggc ctataagctg accggcaatg aacatgcgaa aaaagcggct
     3721 cttctggcag cggatcattt ggcagaacgt tacagagaaa aaggcagatt tctccaggcg
     3781 tggggaaatc ctggcgaacc caaggaatac cgtctgatta ttgactgcct gttaaacctt
     3841 cctctgcttt actgggcaac ggaagtgacg ggggatcctt cttatgaaga aaaggctgag
     3901 aaccacataa aaaccgccat gaaatgcatt ctgcggccgg atcattccac ttaccatacc
     3961 catttctttg atgtggaaac aggggacccg acttatggtg ttacccatca ggggaaccgc
     4021 aatggttctg cgtgggccag aggccaggca tggggcattt acggcgtcgc tttaagctat
     4081 cggtatttaa aaaatacaga atacatggat ctgttttgca gcataactga ttattttatc
     4141 aaacaccttc cggaagatct tgttccttac tgggattttg actttgatac gggtagtaca
     4201 gagccgagag attcttctgc ttctgccatt gctgtatgcg gtatcctgga aatggcaaaa
     4261 tatctggata aagataaggc tatggtatac ttagatgcag ccgaccggat gttgcgggcc
     4321 ctggtggatc attgcgccaa caagaattat caaaaatcca atggattgct gctccacggt
     4381 acctatgcca gggattccaa agaaaatacc tgtaccaacc ggggagtaga tgagtgcaat
     4441 acctggggcg attattttta catggaagcg cttaccaggc tttccgggga ctgggagctg
     4501 tactggtagg atctgctgaa aaaataagga gaaaaaagaa tgaaaacgaa tctgctgtat
     4561 gtttttgctg accagtggcg ttatcacgcc atgggattta tgaacatgga tcaggtggtg
     4621 actccaaaca ttgactcctt tgcccaggag agcatgagat ttaccaatgc ttacagtacg
     4681 taccccttat gttctcctca cagagcttcc cttatgacag ggaaatatcc tttccgcgct
     4741 ggaatgtgga ccaattgcaa aataggattg gaagagaagg tcatgctaag gccccaggag
     4801 gtatgtatcg gagatatact gaaaaccgaa ggctatctta cgggttatat tggaaaatgg
     4861 catttggatg catcagagct taacttcaca tccagtccga aatcaggggc aaaagactgg
     4921 gatgcttata ctcctcctgg agaaagaagg catggatttg attactggct gtcctatgga
     4981 gcctgggatg atcacttgga tccccattac tggcaggatg atgaaaggca gataaagccc
     5041 ggaaaatggt ctgcggaatt tgagacagat aaggccattg aatatatgga atcaaggaaa
     5101 gatgaggatc agccttttgc cctgttccta tcctataatc ccccccatct tccatatgag
     5161 ctggtacctg accggtatta tgagaagttt aaggatttgg aaattcaata ccgggaaaac
     5221 gtgccggaag aaatgcggca aaaaggaggg cttctagaaa ctcagacaag gcaatattat
     5281 gctgcagttt acggaatcga tgagcagttt ggaagggtcc tccaatattt aaaagatcat
     5341 aacatggagg agaataccat tgtcatcctg tctgcggacc atggagaaat gcttggttcc
     5401 cacgggctga tgagtaaaaa tatctggtat gaggaatccg ttcatattcc acttatgatc
     5461 cgccagaaag ggagaattaa ggcagtagaa aataacagta tatttgcaag cccggaccat
     5521 atgccaacca ttctggagct tctagaaatt cctgttccca aaacctgcga gggctatggc
     5581 cattccaggg ggatgttcgg aacggatgaa aatgagccaa cgaatatgct gatctgttcc
     5641 tatccgggaa gtgcggatat ggtaaaggca ttttctgaca aaggcctcag ccataaggct
     5701 tatggatgga gaggcatcaa agacaagcga tttacctatg tcattttcaa cggttatgct
     5761 ccgggagaag ggcaaatgga atatctttat gataatatag cagatcctta tcagcttcat
     5821 ccggaaatct tggagccgga ttgccaaaga gcagaggttt tagcatacag ggaagccctt
     5881 aaaaattacc tccttcagac ggaagatccg tttttatgga atcggtagaa aaaaatggaa
     5941 taagaggatg ccaaataact tatcccagtc tcggacttca tgccaagtta atttatttga
     6001 tagcacttaa tattatctta ggaatattaa gtgctatatt tttatggctg catttgctat
     6061 aatgagtctg cattaataaa acagggattg aacgaggtag atgacatgag tctaaaagaa
     6121 agagcgaacc aattaataac agatatacct gctatatttt tatgtctgaa aagcagggat
     6181 actccactgg cagctaaaat actggccggg ataacggtcg tctatgctct atctcctgtt
     6241 gatttgattc cagatttcat tccggtactg ggttatttag atgatgtcat cctgttgcct
     6301 gtgctcatag cactgaccgt gaagctcata ccccaaaagc tttttcaaca atttaaaaag
     6361 gaagcaaagg gaatgtggga aaatggaaaa gtgaagtact ggtattatgc aattcccatt
     6421 gtggcaatat ggctgttaat tctttggttc tttgtaaaag caattatttt ttaaacattc
     6481 agggtttcat caatgcatta aattataatg ggaggcagcc gaataactcg gctgcctcct
     6541 ggtaattatg gatgaatgtt atttaaagcc ttctgtactt ttcccatcat acgtatggat
     6601 acagagtagg tttccctgtt attcatgaga agcaaagcgc tttccctgga atattttgtt
     6661 acgtgcttca gatttataat ggtggaacgg ttgcattggc aaaagttaga attcagggtc
     6721 gtatggtatt ccttcagcga gcctgaaatt tgccggactc catttctggt gtgaactgta
     6781 agcttatgag aatcgtcacc agttgtgatt gccacaatgt cattttgatc caggactagg
     6841 gaatctttat caactttaat ggataagagc cggttggaag catcaagctg tactttgtaa
     6901 tttctttccg catttcgaat acaggagcag atttgttccg gcaaggtctc tgcatcatct
     6961 ttagttataa aatccattgc ctccacctta tagcggaagg tcagaacggc catttcactg
     7021 tgtgttgtta caaaaacaac ataaccgcgt ggatcatatt tgcgaatttc ctgagctagt
     7081 tcaattccat ttttatttga ctgtaagtca atgtccagaa aataaagtcc ggtagtaccg
     7141 gaacgcctcc gcatggaaag caattcttcc ggttttgaag tcgcacagta aagcttggtt
     7201 tctgttgggt tcattaataa atatttactt atgatgtctt cccagcggtt tagttgtctt
     7261 gtatcatctt cacataagta gatatggatc atttttgtac tccttatgaa ccattatgta
     7321 ttaggattaa ttcctgtgtg aaataaggtt cttcatatgt ggtattccaa atggcatttt
     7381 catagctttt taaaattaca tctacattaa agagaccaat acctctattt tctccttttg
     7441 tagaaatatc atggcttcga agttctgata tggcataggt tggtggcaga gcggtatttt
     7501 gtataataag atagagatcc ctccctttgt aaaacataca gaaacgtact tctttttctt
     7561 ctgtttccat ggcagcttcc atggcattat ctaaaaatat tcctaagatc cgggaaagat
     7621 ccagacaatc catgtttaaa gcatttattg gttcagtaag ttctatttcc gctttgatac
     7681 ctatctccat catgtagacg aatttggagg agagtaagct ttttaacgcg gtattcttta
     7741 tattggagag atttcctaac ttggtatctg attctgtaaa agcacggctg atggggagga
     7801 ttctttctcc ataatattcc tttagtccat ccatatcatt ttctttcaga aatcctgaca
     7861 tagtaataag tatgttcatg taatcgtgct tgaatttacg cataatgccg taagactttt
     7921 ctagacgctt cgtgtagaca cgaagatttt caaattgtgc catgcggtgc ttataagcct
     7981 gttctcccat ggtaacttta taaacggaat acatgagaaa gaccgtgatt aagaacaata
     8041 atagaaaaat aattccattt attgcgatga ctccataatt ataaccaagg cgttccccat
     8101 atgaaaaatt aaaaatataa aagaacacca acagaaaaag atcaataaaa atagctttca
     8161 gcagatgatt gttggttaaa tattttgcta tatttaattt tttatgaaaa taatagccaa
     8221 taagcttggt tgtagttccg cagaacatac agtaaacgca tgaaaaggta acgagtaaca
     8281 aatggtgagt tagtaaagct tccatatcca ttttaaaaat gaaaccagct atccacataa
     8341 acaggtaatt aaatgtgatt gtataaagat atccaaataa atagcaggat agacttaaat
     8401 actgattatt agtaaaaaag tagattaaaa gtatgattcc taaaaaagta ataaatgtac
     8461 tggcctgtcc aaatattcga ttaaaaagaa aaatggtact aaaggcatat aaaaatataa
     8521 taactcgttt aagaattgtc aacttattag gaagcaaatg tacacaaaaa aagtaaacac
     8581 ataaggctcc tgtaagtgta taaataaaat aaatcatgat atatctcctc gccagtagat
     8641 gtatgaatat attttacatt gttgtaatta gaaagtaaag gaaattgtat aaaaagtagg
     8701 ttcattttac gcttaggaag aaaaatacaa cggaaattga aaaaatatac tgctgatcaa
     8761 aggatatggt aatatatggt caaatggtgg tgataaaatg agtattacaa gaattgctgt
     8821 tggtttttgc ggctggttga acaagattag ccctagaagt caagaagaga ataaagtaat
     8881 tcaatatgga atggaattgt tgctggataa tgttattaaa cttatcgtta tttcgcttat
     8941 tggaattttc ttaggaaaag gcttagagac ctttgtggtg ttagctgcat tttgcggctt
     9001 aaggttacag gctggcggta ttcatgctaa aacaggtttt ggttgtggat ttagtatgct
     9061 agtagtttgg gcaatatcta ttttaggtga tatgttcttt ggtataagag cttccttctt
     9121 accgtatatt tatgctgttt cagttttagt cattctttgc tgtgctccgc ggtcaataaa
     9181 tattgagcac tttagtgtgc atgataaatt aaagaagaaa atatattcaa ttactatttt
     9241 gaccttaatt atgacgattg cctttttaaa tccgtctttt agagagctac ttgtataccc
     9301 ggtttctttg gaagtcttaa cattacttcc taaaaataaa ataaatgtag aaagagagaa
     9361 cgaatgatga aaaagatggc agtagaagaa ttgcagaaaa tgttagtaaa ggtatccctt
     9421 aattccgtag ggaagagtat tccggccgca atctatgaaa gaaaaattcc ggatgcagtg
     9481 ttaaagatgc ataatgagaa tgctaaataa gagattgatt aggaaaatat ttttgttaat
     9541 taactcaagt acaaaaagtc cggtatgagt tatataatga taatgtaatc attatagata
     9601 gaaaaagcga tgctatgaca aagaatatta tacataaaaa ttttttgtag gattttcttg
     9661 ttcaattagt tggaatgtgt atgatatgat tactgcagta acaaggggga aacttttgtc
     9721 tgttttatta agattcctat taacaagtta aacatggaat ttggcttcgt acagaagttt
     9781 tatgatactc agtaaaataa ggtataaatg attactgccc tttgagctaa tttcaaaggg
     9841 cagttagtca atataggagc tatttgcatg gaatatgttt gggataagat aggagaaaag
     9901 tcagatgata aagaaactat atcaaagaat tttaatactg gattataata tagcagatgt
     9961 atttgtgcat aagaatatca tgtcaaagcg cagaaaaaga aagattattc cagatgaata
    10021 ttttattgat gtgacagcca ccataccgga aagaaaagtt gtagtagaaa atattatatt
    10081 taatcaatgt gagtaactga ttaaataatt aaaaacaatg tcatataagg ctgaatatta
    10141 tattaaatat tagaatcact gtaattattt gttcagcccc ctaatttaaa aaatgtttcg
    10201 gagtattaat aattacgtac cgaaatgcgt tgtatggagg agtggaatct aatttgtgcc
    10261 tttggaaata atggcttctt tttggtaaga ttaaagatat gaaaattctt atcgaaaaga
    10321 agtcttttta ttgcagttgc taaagggcaa attaaacaga ttttttgagt gcaaaatgat
    10381 gattaaaaga aatgctaaac gtataattgc ggaaaaacgc acctcgtaag aatatgcatc
    10441 tttccagact ttgttgaaat gacaactatt ggaaagaacc tattttgcgc ttaagatttt
    10501 atagactgaa tacataagaa acactgttat aagaaatagc atcaggaaaa taatcccatt
    10561 taatgcaata acatcatgag tatagccaag gcgttctcca tatgaaaagt taaatataca
    10621 aaaaaatact agcaatagaa gataaacaaa aatagttttt aataaatcgc gattagttaa
    10681 gtacttagca atatttaact ttttatgtat gtaataagca attaatttaa gagaggttcc
    10741 gcaaaacatg caataaatgc aagaaaaaat tataagaagc aaattacgtg taataagtgc
    10801 ctctatatct attttaaaga tgaaaccaac caacaataaa aacagatagt taaatgtaat
    10861 tgcataaaga tagccaaata aataacagga tagacttaag taacgattat ctgtaaaaaa
    10921 atatatcaag agtatgtttc ccccaaaggt gataaatgta ctggcctgtc catagattcg
    10981 gccaaaaaga aaaaaaatga taaaagtgta tgaaaataca acaagttgtt taataaatgt
    11041 caacttatcg ggaagtaaat atatacaaaa aaaataatga catatggctc ctgtaaaagt
    11101 ataaataaaa taagtcatga tgtatctcct cgccagtaga tatatgtata cattttacat
    11161 tattgttaat ggaaagtaaa ggaaattgta tgaaaagaat gtgcattttg cccatagata
    11221 taaaaatgtc acgaatattg tatgaatatt ttgttctcgt taaaagatgg tgatatgtgg
    11281 ttaaatggtg gtgataaaat gagggagcag attgggtctc tggtctgcaa gtattgcctg
    11341 tgccgttaac cagaataatc aaataacatt ccgcctatct ttccatgaaa tgcagggaat
    11401 caaacaggta cgtactatta gcgtcggact tcctccggcg ctttttatga tggttcgtga
    11461 cccggttgag tacgaaaaac gtacgaaaca tgaactaccc gctatgcggt caatgtcaac
    11521 ttaagcaaat atctaataaa attcattagc acagaacact tgacaaaata atcaaaatgt
    11581 tgactagcat gattgccgaa tttgaatgca aggtgctttt atgaattccc gtctggtttt
    11641 attcttcaat ccactcacaa atcaattctt atatccgtcc tccattatga aaaaaaagtc
    11701 ccagccggat tactccatga atatctccgt tatatatgcg atttcactgg ccggaatctt
    11761 aatcccgaaa atattttctg catattccag tttgtgttct accgtgtaca taagctcatg
    11821 atgttcgttg gtgaagccgt tgagccgggt atagctccag gtctctccgc gaatggcccg
    11881 ctccagcata ttacagcaat ggcatagata cttggctgca atttcattgg aataagggat
    11941 cttgagatcc agcaatgtgg ccttcaggca tttttcaagt acattaacag ccttagtggt
    12001 gtctaaaaat accgtagttt tggaaattac cttgtctact aaattctgaa taaaggcttc
    12061 ctgggagctt aagttagctg cacggctact gtgggtctga ctggcaggcg tcaggaggga
    12121 gaaatccgaa cggttggaca gtatctgacg aatggtttcc aggagcaaag gcagggtgac
    12181 ggggtagagg atgttggtgt caatgccagt ttgtctggta atatattcgt tgatggtggt
    12241 caacggctcc atatcggtga aaatcaggat gccggagcca cggtttaact gctttgcctt
    12301 ttccactgct agatccaggc actcctttaa gctcatggtg gaggagaagt tgatataatc
    12361 tataatatag tcatcataaa tggttttcag ggcataactc accatgtccg aagcaatcgt
    12421 ttcaccatgg cagatcacta aaagtcccag attaacggtt gttatccagt tggaaaaaat
    12481 ggcaaaatag gaggccaggt aatcaatttc ccggttggag aaataacagg agtaaatctg
    12541 agacagattt tccataatat ccagagccat ctgatattct tccgggaaac tgtccaggga
    12601 tgcggcggga gcctcgcagg gatctggcag caaatggctg tcttcccttt ttaaaaaatt
    12661 ggtgatatgc aaaagaatcc catataaaag atggatatgc tttttgctct cctcaaactt
    12721 gcctttcttt tgcagctgag cgataacaat ctggaataca ataggataga tattccgctt
    12781 aatggcatga agctctgtat ccctgcagtt ggacagccgg gcgatgtttt ccactacggt
    12841 ctgataaatg ttgtcaatgg attcgatctc catgctcaga tggttttcca gaagctgctg
    12901 gtggctggcc tcggatgtag agggggcgga tttaaatgaa tttaagtatt tggaacctcc
    12961 gttttggtcc agctcgatgt actggtcagg tatttcctcc aggatatggc ggacaagctc
    13021 ctgcttgttt gcggaacaat ctatgaaaga aagaagctct tgggacagat cgtgaagatg
    13081 gatgtaaaca gtccggcagt ggttagaaag gctgtccaga taggcacggg agcaggcggt
    13141 cttgatttca ttcatcagtt gaatgatatt tctggtatag ttcatgttag ccatacagga
    13201 aattgcgtct ttggaaattt ttataggaag atggatgatg cgtgcttcct cagaaaagag
    13261 ctggatgatc agctctattt tttcgtggat cccccgtacc tccagatcag ggatggaaat
    13321 ggcagaagga aacctttccg ccaaaatgcg aatggggtca ttgctgcttt tgcaggtggt
    13381 ggaggcgatt atcatacact ggaggtcacg cagggaggta tcgccgatac ggttataata
    13441 gtttttagta attactgagg taataagttc caaagaggca ggagacaggt gctcgattcc
    13501 atcaaagaaa agaatccctc ctttggctgc gtccaggaag ccgcgccgcg atttgttaga
    13561 gactacatct ctggccagtc ccagaagctg ctgggaaaac agtttgggat tgtcagaaaa
    13621 gctatggcag gtcacgggaa taaagggaat ggcactgtca gttgaggcca gcgttttttt
    13681 gtatagatac atacagtggg cgaatttgct tttgcccacg ccgatggagc cgaagagcag
    13741 ggtgtgtagc ccataaggcg gataggaaac agaggccttg gcaagggcaa tgatatcctt
    13801 aagactggtg tccgctccga ttagctcttc cagaaagata gctctgtctg attgtttcct
    13861 gttgtccgaa gccttgatca gattggaaag aacttcacct tttgccacgg tctgagggat
    13921 aaaaaagccg ggctggtatt ctgttaccag ctttctgtcc aaaaacaggg tgggttttcc
    13981 ctgaaatttt atcaggaggc catcccgcca gagatcattt aaggctctgg atacgtttgc
    14041 cctgtccatt ttcaggtcaa tggcaagggt ataggcatca acgccatggc cgtcaatatc
    14101 tccactttca agaatttgca gggtctgttc ccgtacggaa ttcagtatag ttgtgttatg
    14161 tgtcattgca gtggctctcc tttgcatttt tttgtaaaaa tgcgtgtaat atcttggtga
    14221 aattctaaca cggatcatat tgaaacgcaa ggaaatacgt gaaagtgtgt aaaaatcatc
    14281 gccatacttt gacacacatt acacaaaagg tatttacttc tttaataaaa aatgaaaatt
    14341 atgtaaaatg tataaacaca aatgagaaat gtgttaattt atgatgaaat tttacataac
    14401 aaaccctatt acagtatgat gagagcaaga aaaattatgt aaggaggtta tatgagtaaa
    14461 gtacttttat taagtcatgg ggatttagcc agggaaatat gggccacatc caacatggtg
    14521 ctgggagaga tgtcaggagt ggagtattta acgcttccgt tgggtacaga tttaaaccgt
    14581 tatgagcagg acatccgccg taaaatagag gatgcggaag atgggctcct gatcctgact
    14641 gacatttttg gaggaacgcc gtttatcaca gcctctcgtg tgttcgcctc attggaggac
    14701 aaggaccggg tggagatagt aacaggcatg aatctggcta tggctattca ggtatttaat
    14761 tttgtgggaa atatgccggt aaaagaacta aaaaagatcg cggtgacagc gggtactgag
    14821 ggaatcgtgg acttgaagga acggatatga gagaagggaa aggagcagaa aatgagcgtc
    14881 aggatgattc gaatcgatga ccggctgatc catggacaga ttgttgcggc atgggcgaaa
    14941 aacctgtcca tcaaacgaat atggattgta gatgatgatg tggctaagga cgcatttatc
    15001 acgaatgtaa tgaaaatggt atctccgccg gatacagagc ttgtgattac tggtactgac
    15061 aaggcaaggg agatggcgga ggaattcgac gccgcggaca aaaacacgct gatcctggtg
    15121 aaatatccca aggtcgcaag gctgttgttt gacacagata tcagactcag agaactgaat
    15181 gtaggcggaa tgggggcaaa tgcagaacgc aaaaagctgt ttaagaatat ttctgccagt
    15241 gaggaggaac ggaaaacttt aaaagatatg aaggaatccg gagtaaaggt gtatttccag
    15301 gtaacaccca atgaaaagca gacactattt gaaggatgaa cggtaaaggg ggaaacaaca
    15361 tgttaattca atcgatttta gtagctttct gggcatggtt taacggcatg gtggtatcgg
    15421 aatatctggt atggatcgtc agaggcgcgc cgcttgtaag cggaaccatt actgggatcc
    15481 tgatggggga ctggcgttcc ggcgcaatga tcggagctac catccagctt ctgtacatgg
    15541 gacaggtgac agtgggaggc atttcatctt atgacaaatc ctatgctggc attatcgcaa
    15601 ctgcagttac cattgcttcg caccagacac cggagattgg aatcacgctg gcagttgctc
    15661 tggggactct gggcctgatt gcaagcaata ttttcatgac ggtttgcgtg gcatttgtac
    15721 atatggctga taaatatgtg gaagagggaa aaaccaacag gatatggatc tacaactggc
    15781 tgcttcccaa ccttttgtgc gggctgctgt ggggaattcc ggcttttctg gccgtatact
    15841 ttggctcctc ttatctggag gcgtttatga atcatattcc ggcatttgtg tccaaagcac
    15901 tgaccactgt cggcatgatt cttccggctc tgggaatcgc aatgatgctt aagactgtat
    15961 tcaatcccag gttttctcca tttatcgtgg tagggttcct ttgtgtggca taccttcata
    16021 tggatatcat cgcctgcgcc ctgttaggcg gggcctgcgc agttctttac tggaccctga
    16081 atctggacaa actgacagaa ggaggaaact aaagatggat gaaaccattg ttgcagcaaa
    16141 tgaaaacaat gaaaagaagc tgagaaagtc ggatttgctc cgctgttttt tgatctggga
    16201 gaccacttca gaatcctgct taagctatga acgtttaatg tccttaggct tctgccatgc
    16261 catgacgcct gtgatcaacc gtctttataa gacaaaggag gagcgggcgt ccgcattgaa
    16321 gcgccacatg gtatttttca acacagagaa caattggggg gcgtttatac cggggatagt
    16381 gtgctccatg gaagaggaga gggccaacga aggcaccatc agcgatgaga tgatcaacag
    16441 tgttaaaatt ggtctgatgg gacctctggc aggcattggg gataccatta cccagggact
    16501 attcaaaacc gttctgctgg caatttttgt ggatatgact ttaaagggaa acattgcggc
    16561 gccgtttatt tatgcaatcc ttatgggtgc ttatatcgga gggctggggt attttacgtt
    16621 cttctccggc taccgccttg ggcaaaatgt gctgggcaag atcactgatg tagcaatcat
    16681 gaggaagatc actaacagcc tttctatcct gggactgatt attgcaggag ccatgatggt
    16741 gaataatgtt tccattgtga cgcctcttgc gatcaacatt ggtaagacct ccgtcgtcat
    16801 tcaggatttg ctggattcta ttcttccagg aatgttaagc gtgatttttg ttatgttgtg
    16861 ctttgggtta atgaagaaaa gagtcagtgt gttcaagatc atgattattt tgtttgcagt
    16921 tgccattatt gcggcattat ttggaatttt ataaaattgt gagatcaggc cgcaacgttg
    16981 atatagtttt aatgtactta tagtctgaga tggctgtaac gaaattctta tgaacacact
    17041 tattatattt ccaaggaaaa atatgacagt aaaataaaat gaggctcatg tacttttatt
    17101 acgatttgtg cctgggctaa gcgaaaggaa tgtgagttat tatgagaaaa acctggcttt
    17161 cagatgtcat tggaacagaa aaagcggctt tcggtctggt tcacctgctg gcgcttcccg
    17221 gtgatccgct ttatgatgca gagggtggac tggaaagaat atatgaagca gctttgtctg
    17281 atgttcagtc tcttcaggaa ggagggattg atgcactgca tttctccaat gaattcagtt
    17341 ttccctacca gaagaatcct cccagagaaa tcatggctgc aatggcctat atcattggcc
    17401 gtctgaaacc atatatcaaa gtcccttacg gtgcaaatgt catcagtagt cccagcgaca
    17461 gcgtggcgtt gtgcgccagc gtcggagcaa aattcaccag aggaacattt tcaggggtat
    17521 actccggaaa cctggggctg tatgacactg ccatcggaga ttatgtgcgt ctgcgtcaca
    17581 atcttcatgc agatgacgta aagatgatcc actatgtggt gcctgagtca agcgcggata
    17641 tcggtgggcg tgatcctttg gcctctgcgg cggcgtctaa gtttatgaac atgccggacg
    17701 gatttgccgt gccgggagca actgccggac agtctgcaga tatgtctttg ctgcatcagt
    17761 tgagaaagtc catgccggat atggttctgg tagcttccac gggtgtgaag tatgagacgg
    17821 ttgaagagat attctcaatt tgtgatgcgg catttattgc caccagcctg aaaaaggacg
    17881 gaatatttga aaatcctgtg gataaggacc gggtaaagcg atttatggaa aggctgaagg
    17941 attttaggaa cagcctgtaa aagagggacc tatgttaaag gcagttttat ttgactgtga
    18001 cggcgtactg atggacagtg agagcatcta cctgtcctgt gtttcccaaa tactgggaac
    18061 gctgggcaag ttggcttcag tggaggaact ggcatatctg attggggcag atatccacgt
    18121 tatcactgaa cggctgaaac aggacttcgg cctggagaat tatgatacgg aagaactgat
    18181 ccgcgttcaa aggacgctgt ttaacgagcg gttttatagg gagaaattaa cgcccatgga
    18241 cgggctggaa ggctttttgg aaagtcttaa aaaagagggg attcttctgg cagtagtttc
    18301 ttcctccggc caggactatg tagaatatgt gctggatcga ttaagaatca gggagtattt
    18361 taatctatat aggaggcagc cggccgttcc aagcccttcc cagacctgta cctggaggca
    18421 gtcaggcggc tgggaatcca cgcaaatgag gcggtggtgg tag
//
