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Overview
1.1
1.2
1.3

### Identified secondary metabolite regions using strictness 'relaxed'

NC_014376.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1 | ranthipeptide | 660,316 | 681,989 |
Region 2 | cyclic-lactone-autoinducer | 2,082,442 | 2,100,904 |
Region 3 | cyclic-lactone-autoinducer | 2,666,600 | 2,687,339 |

NC_014376.1 - Region 1 - ranthipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 660,316 - 681,989 nt. (total: 21,674 nt) Show pHMM detection rules used
ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or YcaO or TIGR03882)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | ranthipeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000344.1 |  | 0.06 | NRP | entolysin | Pseudomonas entomophila L48
BGC0000388.1 |  | 0.05 | NRP | mannopeptimycin | Streptomyces hygroscopicus
BGC0000163.1 |  | 0.05 | Polyketide | tetronasin | Streptomyces longisporoflavus
BGC0001598.1 |  | 0.04 | NRP, Polyketide | foxicins A-D | Streptomyces diastatochromogenes
BGC0000144.1 |  | 0.03 | Polyketide | salinomycin | Streptomyces albus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000344.1 |  | 0.25 | NRP | entolysin | Pseudomonas entomophila L48
BGC0000388.1 |  | 0.22 | NRP | mannopeptimycin | Streptomyces hygroscopicus
BGC0000163.1 |  | 0.21 | Polyketide | tetronasin | Streptomyces longisporoflavus
BGC0001598.1 |  | 0.19 | NRP, Polyketide | foxicins A-D | Streptomyces diastatochromogenes
BGC0000144.1 |  | 0.16 | Polyketide | salinomycin | Streptomyces albus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_014376.1 - Region 2 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,082,442 - 2,100,904 nt. (total: 18,463 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000804.1 |  | 0.13 | Saccharide | acarviostatin I03, acarviostatin II03, acarviostatin III03, acarviostatin IV03 | Streptomyces coelicoflavus ZG0656
BGC0000540.1 |  | 0.12 | RiPP | paenibacillin | Paenibacillus polymyxa OSY-DF
BGC0000495.1 |  | 0.06 | RiPP | actagardine | Actinoplanes garbadinensis
BGC0000388.1 |  | 0.05 | NRP | mannopeptimycin | Streptomyces hygroscopicus
BGC0001406.1 |  | 0.04 | NRP | telomycin | Streptomyces canus
BGC0001728.1 |  | 0.04 | NRP, Polyketide | paenilipoheptin | Paenibacillus polymyxa E681
BGC0001598.1 |  | 0.04 | NRP, Polyketide | foxicins A-D | Streptomyces diastatochromogenes
BGC0001011.1 |  | 0.04 | NRP, Polyketide | meridamycin | Streptomyces sp. NRRL 30748
BGC0000171.1 |  | 0.04 | Polyketide | 9-methylstreptimidone | Streptomyces himastatinicus ATCC 53653
BGC0000341.1 |  | 0.03 | NRP | enduracidin | Streptomyces fungicidicus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000804.1 |  | 0.42 | Saccharide | acarviostatin I03, acarviostatin II03, acarviostatin III03, acarviostatin IV03 | Streptomyces coelicoflavus ZG0656
BGC0000540.1 |  | 0.40 | RiPP | paenibacillin | Paenibacillus polymyxa OSY-DF
BGC0000495.1 |  | 0.26 | RiPP | actagardine | Actinoplanes garbadinensis
BGC0000388.1 |  | 0.21 | NRP | mannopeptimycin | Streptomyces hygroscopicus
BGC0001406.1 |  | 0.20 | NRP | telomycin | Streptomyces canus
BGC0001728.1 |  | 0.19 | NRP, Polyketide | paenilipoheptin | Paenibacillus polymyxa E681
BGC0001598.1 |  | 0.19 | NRP, Polyketide | foxicins A-D | Streptomyces diastatochromogenes
BGC0001011.1 |  | 0.18 | NRP, Polyketide | meridamycin | Streptomyces sp. NRRL 30748
BGC0000171.1 |  | 0.18 | Polyketide | 9-methylstreptimidone | Streptomyces himastatinicus ATCC 53653
BGC0000341.1 |  | 0.16 | NRP | enduracidin | Streptomyces fungicidicus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_014376.1 - Region 3 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,666,600 - 2,687,339 nt. (total: 20,740 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001891.1 |  | 0.32 | Other | closthioamide | Ruminiclostridium cellulolyticum H10
BGC0000538.1 |  | 0.16 | RiPP | nisin Z | Lactococcus lactis
BGC0000517.1 |  | 0.16 | RiPP | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0001289.1 |  | 0.16 | RiPP | penisin | Paenibacillus ehimensis
BGC0000616.1 |  | 0.16 | RiPP | amylocyclicin | Bacillus velezensis FZB42
BGC0001222.1 |  | 0.16 | RiPP | acidocin B | Lactobacillus acidophilus
BGC0000486.1 |  | 0.16 | RiPP | butyrivibriocin AR10 | Butyrivibrio fibrisolvens
BGC0000491.1 |  | 0.15 | RiPP | gassericin A | Lactobacillus gasseri
BGC0001229.1 |  | 0.15 | RiPP | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0000500.1 |  | 0.15 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001891.1 |  | 0.65 | Other | closthioamide | Ruminiclostridium cellulolyticum H10
BGC0000538.1 |  | 0.47 | RiPP | nisin Z | Lactococcus lactis
BGC0000517.1 |  | 0.46 | RiPP | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0001289.1 |  | 0.46 | RiPP | penisin | Paenibacillus ehimensis
BGC0000616.1 |  | 0.46 | RiPP | amylocyclicin | Bacillus velezensis FZB42
BGC0001222.1 |  | 0.46 | RiPP | acidocin B | Lactobacillus acidophilus
BGC0000486.1 |  | 0.46 | RiPP | butyrivibriocin AR10 | Butyrivibrio fibrisolvens
BGC0000491.1 |  | 0.46 | RiPP | gassericin A | Lactobacillus gasseri
BGC0001229.1 |  | 0.46 | RiPP | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0000500.1 |  | 0.45 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names