LOCUS       NZ_AP012333.1          10297 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_AP012333.1 Parascardovia denticolens DSM 10105 = JCM 12538
            chromosome, complete genome.
ACCESSION   NZ_AP012333
VERSION     NZ_AP012333.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 13:28:25
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 637558
            Orig. end    :: 647855
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10297
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[642558:642855](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5297
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10297
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10297
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             1397..1819
                     /locus_tag="ctg1_526"
                     /transl_table=11
                     /translation="MPAVQDSIDAVRIAAAAADRMKGEDIVAFDVTEPLAITDIFLLVT
                     GDNPRQVLAIAEEIEKDMHVKLGRDPREREGVSEGQWVLQDYGDFVIHVMDRESRAFYD
                     LDRLWKDCPRIDLQLPESPAPNEAAEADQGSEGAAK"
     aSDomain        1430..1723
                     /aSDomain="TIGR00090"
                     /aSTool="tigrfam"
                     /description="rsfS_iojap_ybeB: ribosome silencing factor"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_526_0001"
                     /evalue="1.40E-27"
                     /identifier="TIGR00090"
                     /label="ctg1_526"
                     /locus_tag="ctg1_526"
                     /protein_end="109"
                     /protein_start="11"
                     /score="93.7"
                     /tool="antismash"
                     /translation="RIAAAAADRMKGEDIVAFDVTEPLAITDIFLLVTGDNPRQVLAIA
                     EEIEKDMHVKLGRDPREREGVSEGQWVLQDYGDFVIHVMDRESRAFYDLDRLW"
     PFAM_domain     1439..1723
                     /aSDomain="RsfS"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02410.17"
                     /description="Ribosomal silencing factor during starvation"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_526_0001"
                     /evalue="4.30E-23"
                     /label="ctg1_526"
                     /locus_tag="ctg1_526"
                     /protein_end="109"
                     /protein_start="14"
                     /score="81.7"
                     /tool="antismash"
                     /translation="AAAADRMKGEDIVAFDVTEPLAITDIFLLVTGDNPRQVLAIAEEI
                     EKDMHVKLGRDPREREGVSEGQWVLQDYGDFVIHVMDRESRAFYDLDRLW"
     CDS             1816..2715
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1101:phosphoglycerate mutase (Score: 74.3; E-value:
                     1.7e-22)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_527"
                     /transl_table=11
                     /translation="MTDTREHVHSIFLVRHGQTSYNAQHRFQGQIDIPLNEIGRWQVKQ
                     TAAELTRLYVGSNGDNTFDVQAGNTVDFGAQSNVAINGDGERVESFASASSPASASSAP
                     PSSSCAVQGELGQSQGSQRRQIVLTSTLSRAQETAHTFADPLGLDVHIDPRVAERNFGD
                     WEGMSMSEVREQFPDDFASWQRFEGGELRHGAETKEAVGLRGLAAINDWAYQAGKDTDL
                     FIFSHGAWINQTLQTVLGMTTIYPDFASLVSMRNAFWVKLSSLDLPDGSVRWRLEEYEH
                     GPVAAYITDWNNPDLASV"
     PFAM_domain     1846..1971
                     /aSDomain="His_Phos_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00300.24"
                     /description="Histidine phosphatase superfamily (branch 1)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_527_0002"
                     /evalue="7.00E-12"
                     /label="ctg1_527"
                     /locus_tag="ctg1_527"
                     /protein_end="52"
                     /protein_start="10"
                     /score="45.5"
                     /tool="antismash"
                     /translation="IFLVRHGQTSYNAQHRFQGQIDIPLNEIGRWQVKQTAAELTR"
     PFAM_domain     2170..2541
                     /aSDomain="His_Phos_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00300.24"
                     /description="Histidine phosphatase superfamily (branch 1)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_527_0003"
                     /evalue="1.80E-26"
                     /label="ctg1_527"
                     /locus_tag="ctg1_527"
                     /protein_end="242"
                     /protein_start="118"
                     /score="93.1"
                     /tool="antismash"
                     /translation="QGSQRRQIVLTSTLSRAQETAHTFADPLGLDVHIDPRVAERNFGD
                     WEGMSMSEVREQFPDDFASWQRFEGGELRHGAETKEAVGLRGLAAINDWAYQAGKDTDL
                     FIFSHGAWINQTLQTVLGMT"
     CDS             complement(2886..4091)
                     /locus_tag="ctg1_528"
                     /transl_table=11
                     /translation="MMSPEIRRYPKAVQIALLSITAVSLLLIVSGFFYGGDVTLLSCVN
                     LTLQCAFIVLLNRFPKSVLWLYAFFLTVSALAPFVSTIEYWGVWLTLLYAGLVLRVRYA
                     LLLAFSFSGLQFLSYAIYRDTSYTFLGVVSVTSLFFFFTFIGIGLRSFNLIQNQRVRIL
                     ELERERAEQDSREWKDDLVAELHDALAGTLTDIALCSYQNQKETDPTVSAQGNALIHKL
                     AMQSVQEIHQIIDIIDDDKPLKESVADTGQAANAARRYGKETIRKFLEAEDLKAQTIGM
                     KGHSLIQGENDILLPKSLHHEMRLTLREIYTNIKKYAAPEGVYLVSVTISREGIAIYSS
                     NRIEKGREKVLQHESGLKNIRQRVSKLNGTVKSWSDDDDLRMTIYFPVKGTRQNGHNHD
                     GQ"
     CDS             complement(4088..4792)
                     /gene_functions="regulatory (smcogs) SMCOG1016:LuxR family
                     DNA-binding response regulator (Score: 65.2; E-value:
                     8e-20)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_529"
                     /transl_table=11
                     /translation="MRSLSENKVGRRIAIVDNDILSLKMLSEIVLGFCDEYRIAWACIA
                     GKAALKHLLEDRHEPDLLLVDVSLTDTTGITLCKNIRRRAIDIPILLITAFPLKKYWFE
                     AKSAGAQGIIGKEDIDLLRESISGLFHDQATAQNPQIAENQSATIFYDFYSPQDSIRHL
                     IKERTTNKELLSQEEKRILYYTIKGKSLKQIASILSVKPSTIRNHAQHAREKLHAGNLT
                     EAAVIWLKERDE"
     PFAM_domain     complement(4115..4276)
                     /aSDomain="GerE"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00196.21"
                     /description="Bacterial regulatory proteins, luxR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_529_0005"
                     /evalue="6.30E-13"
                     /label="ctg1_529"
                     /locus_tag="ctg1_529"
                     /protein_end="226"
                     /protein_start="172"
                     /score="48.2"
                     /tool="antismash"
                     /translation="LLSQEEKRILYYTIKGKSLKQIASILSVKPSTIRNHAQHAREKLH
                     AGNLTEAAV"
     PFAM_domain     complement(4415..4756)
                     /aSDomain="Response_reg"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00072.26"
                     /description="Response regulator receiver domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_529_0004"
                     /evalue="3.40E-15"
                     /label="ctg1_529"
                     /locus_tag="ctg1_529"
                     /protein_end="126"
                     /protein_start="12"
                     /score="56.3"
                     /tool="antismash"
                     /translation="IAIVDNDILSLKMLSEIVLGFCDEYRIAWACIAGKAALKHLLEDR
                     HEPDLLLVDVSLTDTTGITLCKNIRRRAIDIPILLITAFPLKKYWFEAKSAGAQGIIGK
                     EDIDLLRESI"
     CDS             5001..5297
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Lactococcin_972"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_530"
                     /sec_met_domain="Lactococcin_972 (E-value: 5e-07, bitscore:
                     26.8, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKVKRGLMTVLASMAMVTAFAVPTVAFASGADGGNFGCSISGVP
                     GWGYVNSTYYHPSRKHYATAQGKGRQTVWANARGTANARTGRNFSGNKCWYGF"
     PFAM_domain     5124..5288
                     /aSDomain="Lactococcin_972"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09683.12"
                     /description="Bacteriocin (Lactococcin_972)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_530_0006"
                     /evalue="3.70E-08"
                     /label="ctg1_530"
                     /locus_tag="ctg1_530"
                     /protein_end="96"
                     /protein_start="41"
                     /score="33.8"
                     /tool="antismash"
                     /translation="SGVPGWGYVNSTYYHPSRKHYATAQGKGRQTVWANARGTANARTG
                     RNFSGNKCWY"
     CDS             5442..7541
                     /locus_tag="ctg1_531"
                     /transl_table=11
                     /translation="MHRISQITWVIALIFGVFFAYQAFIVMDQNQPFGTESSFHISQVD
                     SKRGVALKALEDVARSQRANIYKVQSNMTSSFNRNELYAFVGDQAAFARAGSYEYPSFS
                     SLSGSYRIRPASSLTFQDIRGEYKTNVGGGRLAAILQALSEKGVMAENDGYPPAVGFAN
                     FFAFGMAESNSGAFILALLLAIILSLAFSCSRHRKAYALKELHGYGKGRIVGQEVRDLL
                     LFSGKAMRIIFLALTVLLGVANHFHQYWRFLSLLIITWAVLLAVGLLAMAVLSRIFIGG
                     IRIVPVMKNQNSTEINFAVGFATQIVIVALIFGALSGSLVRLNAIQQASQELQAWRKAG
                     PLYVTSISTALPQKQMFRDGRAFRQVTDELEIRGQALLAVSHVENNPDAIRTGERSYYS
                     GNYRSLFINDTYLKTNPIHDLTGKKISFSDFRRNQVLLIVPQTFSGDLDALKKNYRADL
                     KDWCQTSEEGAGENKENKGCDPQISLVRAKAGQSYFLYNGTGVGLPAEGQSDNTSRISS
                     LKDPVAAVVNVNSHLIAPEILISYASSSSILFTDPHALSSRLDKAGILGDFAGINNAAD
                     IVAYSIQLSRREQLMDILGVILGLSVFVMAIAVLVSAYCELKKKQNFVQLIHGYPFGRR
                     HAAIMVTGLLVTVAALVFASFIGHMKGADNAVLAVVILLLQVGMTIGMLDFFESRVHAS
                     MIKES"
     CDS             7633..8457
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 112.4; E-value:
                     4.8e-34)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_532"
                     /transl_table=11
                     /translation="MDNSNTNGSDSQAQKAAITVLDASKSFGRHVLWRDWSFSVPSGSM
                     TAVTGPSGAGKTTLINCLGLLEDFNQGTLYYGDKLVLEVDSGVGVDGKAGKKGKAGKAA
                     EAGKTGKTGKTGKTSEGGKLSAQDRRAFFKDTLGFLFQNYGLVDSWTVRQNLEVPLKMR
                     KGLARKDYPSVCRDVLKRVGLEGMEKEKIYTLSGGEQQRVALARLMLKKPTIILADEPT
                     SSLDAANSRMVMEVLREFADQGATVLISTHGQEAIDACDGTLRIPGHEEAVV"
     PFAM_domain     7735..8301
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_532_0007"
                     /evalue="2.90E-27"
                     /label="ctg1_532"
                     /locus_tag="ctg1_532"
                     /protein_end="223"
                     /protein_start="34"
                     /score="95.9"
                     /tool="antismash"
                     /translation="DWSFSVPSGSMTAVTGPSGAGKTTLINCLGLLEDFNQGTLYYGDK
                     LVLEVDSGVGVDGKAGKKGKAGKAAEAGKTGKTGKTGKTSEGGKLSAQDRRAFFKDTLG
                     FLFQNYGLVDSWTVRQNLEVPLKMRKGLARKDYPSVCRDVLKRVGLEGMEKEKIYTLSG
                     GEQQRVALARLMLKKPTIILADEPTS"
     CDS             complement(8539..10155)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1038:phenylalanine-specific permease (Score: 379.5;
                     E-value: 2.9e-115)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_533"
                     /transl_table=11
                     /translation="MQTEQQSQVSVGSSQTGVQPAGGGHATPTDSRTASRTVKRNLRTR
                     HVSMIALGGSIGTGLFIASGETIHSAGPGGALVAYAAIGIMVYFLMTSLGEMATYLPTT
                     GSFAIYASRFVDPALGFAMGWNYWFNWAITVAVDTTTSSIVLRYWFPQVPLWVFSLVVL
                     SLIFLINILAVRAFGETEYWLALVKVITVLVFLTIGLLTIIGIIGGKAPLLTNFTYRKA
                     PFVGGFPAVLGAFAIAGFSFQGTELIGITAGESANPEKSIPKAIKQVFWRILLFYILSI
                     FVIACLIPYTSPNLLGSSASDISISPFTLVFQRAGLAAAAGVMNAVVFTSVLSAANSGM
                     YASTRMLYALAKEKQAPGIFGMVNFHGIPVPALLGTTFVAFMAFLSSIFGEEIYTFLVA
                     ASGLTGFIAWAGIAISHYRFRRAFLRQGHRLSELRYRAKLFPFGPLLALILCILVIIGQ
                     DLHSFAVWDWRAIGITYMSVPLFLILFLAYKFKNHTKLIPLDQVDLSRSPIEDQASDQA
                     ANRAEEESLSELKSRLAADRR"
     PFAM_domain     complement(8674..10020)
                     /aSDomain="AA_permease"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00324.23"
                     /description="Amino acid permease"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_533_0008"
                     /evalue="2.10E-128"
                     /label="ctg1_533"
                     /locus_tag="ctg1_533"
                     /protein_end="494"
                     /protein_start="45"
                     /score="429.0"
                     /tool="antismash"
                     /translation="HVSMIALGGSIGTGLFIASGETIHSAGPGGALVAYAAIGIMVYFL
                     MTSLGEMATYLPTTGSFAIYASRFVDPALGFAMGWNYWFNWAITVAVDTTTSSIVLRYW
                     FPQVPLWVFSLVVLSLIFLINILAVRAFGETEYWLALVKVITVLVFLTIGLLTIIGIIG
                     GKAPLLTNFTYRKAPFVGGFPAVLGAFAIAGFSFQGTELIGITAGESANPEKSIPKAIK
                     QVFWRILLFYILSIFVIACLIPYTSPNLLGSSASDISISPFTLVFQRAGLAAAAGVMNA
                     VVFTSVLSAANSGMYASTRMLYALAKEKQAPGIFGMVNFHGIPVPALLGTTFVAFMAFL
                     SSIFGEEIYTFLVAASGLTGFIAWAGIAISHYRFRRAFLRQGHRLSELRYRAKLFPFGP
                     LLALILCILVIIGQDLHSFAVWDWRAIGITYMSVPLFLILFLAYKFKNHT"
ORIGIN
        1 ccagctccat ccccaatccg aggcggtcgt ggtccgttat caggcccagc gggtggccga
       61 agccgcttcc agctatcagg acgatgcaat catcgtcaac caagatgaga tctcaggaac
      121 aggccgggcc gtccagtgcg ccgtcttcga actggagaag cgcaacgctt tccaagggac
      181 cgtcctcatc gccgcctccg acatgcccct gttggatacc gccactctga gccagcttct
      241 ggaagcgcat gagtccaacg gggatgcggc gaccgtcctg accaccagtc tggagaatcc
      301 tttcggctat ggccgtatca tccgtgatcc cgacggcaac cttttgcgca tcgtcgaaca
      361 gaaggacgcc aatgccagcg aacttgccgt gcacgaggtg aacacctccg tctacgcctt
      421 cgacgccaag atcctttccc aggccatcgc cggcttgacg acagataacg cacaagggga
      481 gttctacctg actgacgcct tggaaaccgc ccgccacatc ggtcacgtgg gggtcttcca
      541 agcccctgac tacctggccg tggagggcgt gaacgatcgg gtccagctgg cccgcctgct
      601 gaaggcccat aacgtgcgtg tttgcgagga gtggatgcgg gccggggtca ccatccaaga
      661 cccggacacc acctggatcg atgacgaggt aaccattgag cctgacgccg tcatcctgcc
      721 cggttcctac ctgcaaggaa agaccaaggt tggcgcccat gcggtcatcg ggcccgacac
      781 cactttgatc gatgccgaag tcgaggggga ggcccacgtg gaaagatccc gggtggagag
      841 ctcccacatc ggtcgcaagg ccaccatcgg tccttggact tatctgcgcc ccggcaacca
      901 tctgggcgaa gagaccaaag ccggagctta cgtggaaatg aagaaggcca ccatcgacaa
      961 gggaactaag gtcccccatc tgagctacgt gggcgacgcc catatccatg accacaccaa
     1021 cgtcggcgga ggcaccatca cggccaatta tgacggggtt cacaagaacc ggacggaaat
     1081 cgggtcgaac gtccatatcg gcgccggcaa catgctggtg gccccggtga ccgtgggaga
     1141 caacgtcact tccggcgctg gcagcgtcat ccggcacgac gtgcctgaca acgccatggt
     1201 ctactctgag aattcccagc gcatggtgga ggagtggaag ccggcttggg agcggacggg
     1261 agccaggtcc gacgattcca cggatgattc cgagggtgat ttcatggatg accgcactga
     1321 caaccgctct cgcgactcca ggccgagtaa cgagtaagca gaacgaaaca gaacggaaca
     1381 caataaagga gacttcatgc cagcagttca ggattccatc gacgccgtcc gcatcgccgc
     1441 ggccgcggct gaccgtatga aaggcgagga catcgtcgcc ttcgatgtga ccgagccatt
     1501 ggctatcacc gacatcttcc tcctcgtcac cggagacaac ccccgtcagg ttctggccat
     1561 agccgaagag atcgagaagg acatgcacgt caaactgggc cgtgaccccc gtgaacgcga
     1621 aggcgtcagc gaaggccagt gggtcctgca ggattacggg gacttcgtca tccatgtgat
     1681 ggaccgcgaa tcccgcgcct tctatgattt ggaccgcctg tggaaggatt gccctcgcat
     1741 cgacctccaa ctgcctgaga gcccagcccc aaacgaggcc gcggaagcgg accaaggatc
     1801 agaaggcgca gcgaaatgac agacacgcgc gaacacgtcc attccatttt cctggtccgg
     1861 catggtcaga cctcctataa cgcccagcat cgttttcagg ggcagatcga catccctctg
     1921 aacgagatcg ggcgctggca ggtgaagcag acagccgccg agttgacccg cttgtatgtg
     1981 ggctccaacg gagacaacac ttttgatgtt caggccggca atacggtgga cttcggcgcg
     2041 caaagcaacg tcgccatcaa cggggatggg gagagggtcg agtccttcgc ctccgcttcg
     2101 tcgccggctt ccgcatcgtc tgctcccccc tcttcctcgt gcgcagtcca aggagagctt
     2161 gggcaaagcc agggttccca acggcgacag atcgttctga cttccaccct cagccgagcc
     2221 caagagacgg cccatacttt cgcggatccg cttggccttg acgttcacat cgacccccgt
     2281 gtggccgagc gcaatttcgg cgattgggaa ggcatgtcca tgagcgaggt ccgggagcaa
     2341 ttccccgacg acttcgcctc ctggcagcgg ttcgaaggcg gggagcttcg tcatggggcg
     2401 gagaccaagg aagcggtcgg cctgcgggga ttggcggcca tcaatgactg ggcctatcag
     2461 gctggcaagg acaccgatct tttcattttc tcccacgggg cttggatcaa tcagaccttg
     2521 caaaccgttc tgggaatgac gaccatctat ccggatttcg cttccctggt ttccatgcgc
     2581 aacgccttct gggtcaagct ctccagcctg gatctgccgg atggatccgt ccgctggcgt
     2641 ttggaggaat acgagcacgg tcctgtggcc gcctatatca cggattggaa taatcctgat
     2701 ctggcttccg tttgactatt tgactgtggc gtgacctttt aaggaggcag ggtgcgagga
     2761 ttcctgaggc tgtgtacggt ttcccttctg ttaatgtctt tgattttcag caggtttttc
     2821 ctgtcacctc cccagtctga aggggaggct tttgcggcgg agcaaacggt cactcctatg
     2881 cacaatcatt gtccatcatg gttatggccg ttttgccggg ttcccttcac agggaaataa
     2941 atcgtcatgc gcaagtcgtc atcgtcgctc catgacttca ccgtgccgtt gagcttggag
     3001 acccgctgtc ggatgttctt cagtcctgac tcatgctgga ggactttttc ccgtcccttt
     3061 tctatacgat tggaagagta aatagcgatt ccttcccgtg agatagtcac cgatacgagg
     3121 tagaccccct cgggcgcagc gtattttttg atattcgtat aaatctcgcg aagggtcagc
     3181 ctcatctcat gatgaaggct ttttggaaga aggatgtcgt tttcgccttg tatgagcgag
     3241 tgtcctttca tccctatcgt ctgcgccttg agatcttcag cctcaaggaa tttccggatc
     3301 gtttccttgc cgtatcgtct ggctgcgttt gcggcctgcc cggtatcggc aaccgactct
     3361 tttaaaggct tgtcatcgtc gatgatgtca atgatctgat ggatttcctg cactgactgc
     3421 atagccagct tatgaatgag ggcattgccc tgcgccgata cggtgggatc cgtttccttt
     3481 tgattctgat aggagcataa ggcgatgtcc gtcagcgtac cagcgagagc gtcatgaagt
     3541 tcggccacca ggtcgtcttt ccattcccgg ctgtcctgtt cggctctctc cctttccagt
     3601 tccaggattc ggacacgctg gttttggatg agattgaaag aacgcaatcc gatgccgatg
     3661 aaggtgaaaa agaagaaaag ggatgtcacg ctgacgactc ccaggaatgt gtatgatgta
     3721 tcccgataaa tcgcatagga aaggaattgc agaccggaaa acgagaatgc aagcaaaaga
     3781 gcgtagcgga cccgcagaac gagaccagcg tacaggagcg taagccacac tccccagtat
     3841 tcgatcgtcg atacgaatgg agccagggcg cttaccgtga ggaaaaaggc gtaaagccat
     3901 agaacggatt tcgggaaacg attcaacagg acgataaaag cgcattgcag tgtcagattc
     3961 acgcacgaca gaagagtgac atcgcctccg tagaagaatc ctgagacgat caaaagaagg
     4021 gacaccgcag tgatgctcag caaggctatc tgaacggcct tggggtaacg gcggatttcc
     4081 gggctcatca ttcgtccctc tccttcagcc atatcaccgc cgcctcggtg agattccccg
     4141 catggagttt ctcccttgca tgctgcgcat gatttctgat ggtcgatggt ttcaccgaga
     4201 ggatagaggc gatttgtttg agggactttc ctttgatggt ataatagagg attcgctttt
     4261 cctcttgtga cagaagctcc ttgtttgtcg tcctttcttt tatcagatgt ctgatcgagt
     4321 cctgtggtga atagaaatca taaaaaattg ttgcggattg attctcggca atctgcggat
     4381 tctgggcggt cgcctgatca tgaaacaaac cactgatgga ctcgcgcaag agatcgatat
     4441 cttctttccc aatgattccc tgtgctcctg cggattttgc ctcaaaccaa tattttttaa
     4501 gggggaatgc cgtgataagg agaatgggga tgtcgatagc acggcgtcgg atgtttttac
     4561 agagagtgat cccggtcgta tcggtgaggg aaacatctac cagaaggaga tctggttcat
     4621 gccgatcttc aagaaggtgt ttgagcgcgg cctttcctgc tatgcaagcc catgcgatgc
     4681 ggtattcatc acaaaagcca aggactattt cagacaacat cttcagggaa aggatatcgt
     4741 tatcaacgat ggcgatccgc cttcccacct tattttcaga caagcttctc atgctctttt
     4801 taatctcctt ggtggcatca tggagtaaaa gctcgatgac atcctgagaa gacggtagca
     4861 cacaagtctg aaatgcgtgg attctccctt ggggagcggg acaatcgtcc ttgttggtgg
     4921 cgtaggagac caatgatggg taccgttggc agggagggag aaatatgaga tgagtgttca
     4981 ttttattcaa aggagataaa atggaaaaag taaaacgggg tctgatgacc gtcctggctt
     5041 caatggcgat ggtaaccgca ttcgctgtgc cgactgtcgc ctttgcttcc ggagctgatg
     5101 gcgggaattt cggttgctcg atttccgggg tgccaggatg gggatatgtg aattccacgt
     5161 attaccatcc atcacgcaaa cattatgcga ccgctcaagg caaaggtcgt caaacggtct
     5221 gggcgaacgc cagaggcacc gccaatgctc gtaccggtag gaatttcagc ggcaataaat
     5281 gctggtatgg cttttaagcc cggccagtat ctgccatact gttaaactcg gaaagaaagg
     5341 cgatgggtca gcccgctttc ttagaatgag ttacgatggg tgtaagaaag cggactgggt
     5401 catcgcccgt cctgcctgct catgaaaaag gatcttttca gatgcataga atctctcaaa
     5461 taacctgggt catcgccctg atcttcggtg ttttcttcgc ttatcaggct ttcatcgtca
     5521 tggatcagaa ccagccgttt ggcacggaga gctccttcca catcagccag gtggactcga
     5581 aacgcggtgt cgccctcaaa gccttggaag atgtggctcg gagtcagaga gccaatatct
     5641 acaaggtcca atccaacatg acctcctctt tcaacaggaa cgagctctac gctttcgtcg
     5701 gcgaccaggc cgctttcgcc cgggccggtt cctatgaata tccttccttc tcctccctct
     5761 ccggcagcta caggatccgt ccggcttcca gcctgacttt ccaggacatc cgcggcgagt
     5821 ataaaaccaa cgtgggcggc gggcgattgg ccgcgattct ccaagccctt tcggagaaag
     5881 gggtcatggc ggaaaacgat ggatatccgc cagcggtcgg cttcgcgaat ttcttcgctt
     5941 tcggcatggc ggaaagcaat tccggcgcct tcatcctcgc cctgctcctg gccatcatcc
     6001 tttccctggc tttttcctgc tccaggcaca ggaaggcgta cgctctgaaa gagcttcatg
     6061 gatacggtaa aggacggatc gtcggccagg aagttcgtga cctgcttctt ttctccggga
     6121 aagccatgag aatcatcttt ctggcgttga ccgtgctttt gggggttgcc aatcatttcc
     6181 atcaatattg gcgtttcctt tcgcttctga tcatcacttg ggcggtcttg ctggccgtcg
     6241 gccttctggc tatggcggtt ctgagccgaa tcttcattgg agggatcagg atcgtccccg
     6301 tgatgaagaa tcaaaacagc acggaaatca acttcgctgt cggtttcgcc acccagattg
     6361 tgattgtcgc tttgattttc ggggctttat ccggttccct ggtccgtctc aacgccatcc
     6421 agcaggcgag ccaggaactg caggcctggc ggaaagccgg tcccctttac gtcaccagca
     6481 tctccaccgc tttgccgcag aagcagatgt tccgagacgg tcgggctttc cgccaggtga
     6541 ccgatgaact ggagatcagg ggacaggcct tgctggcggt ctctcatgtg gaaaataatc
     6601 cggacgccat caggacgggg gaacggagct attactcggg caattatcgc tcgcttttca
     6661 tcaatgacac ctatctgaag acgaacccca tccacgacct gacgggcaaa aagatatcct
     6721 tctctgattt ccgtcgtaat caggtcctcc tcatcgttcc tcagacattt tccggcgacc
     6781 tggacgcttt gaagaagaat taccgggctg atctgaaaga ttggtgtcag acttcggagg
     6841 aaggcgccgg cgagaataaa gagaataaag ggtgcgatcc gcagatctct ctggtccgcg
     6901 ccaaggcggg gcaatcgtat ttcctctata acggaaccgg ggtggggctg ccggctgaag
     6961 ggcagagcga caatacgagc cggatttcca gcctcaaaga ccctgtggcg gcggtggtga
     7021 acgtcaactc ccacctgata gccccggaga tactgatctc ctatgcctca agcagcagca
     7081 tcctcttcac cgacccccac gccttaagct cccggctgga taaggccggt atcctgggcg
     7141 acttcgccgg aatcaacaat gcggccgaca tcgtcgccta ttccattcag ctttcccgca
     7201 gagaacagct gatggatatc ctgggggtca tcctggggct ttcggttttc gtgatggcca
     7261 tcgcggtcct ggtcagcgct tattgcgagc tgaagaagaa gcagaacttc gtccaactga
     7321 tccatgggta tccctttggc cgccggcatg cggccatcat ggtgacgggc ctgctggtga
     7381 ccgtggcggc cttggtcttc gcatcgttca tcggccatat gaagggggcg gataacgcgg
     7441 ttctggccgt tgtgatcctg ctcctgcaag tcggcatgac catcggcatg ctcgacttct
     7501 tcgagagccg ggtccatgcc agcatgatca aggaaagcta ggaccgggga aagctagagc
     7561 caggaaactc aagacatcgt caaggacaaa agacatcatc gaagatatca tcagcgaaac
     7621 ggaggaatca tcatggataa ttcgaatacg aatggttcgg attctcaagc gcagaaagcg
     7681 gccatcaccg tcttggacgc cagcaagagc tttggccgtc atgtcttatg gagggattgg
     7741 tctttcagcg tcccctccgg ctcgatgacc gccgtgaccg ggccttcggg agccggcaag
     7801 acgactttga tcaattgcct agggctcctg gaagacttca accagggaac cctctactat
     7861 ggggacaagc tggttctgga agtcgattcc ggagtcggag tcgatggaaa ggcaggaaag
     7921 aaggggaagg caggaaaggc ggcagaggct gggaagacag ggaaaactgg gaagacaggg
     7981 aagacgagcg aaggcgggaa actgtccgcc caagaccgcc gggccttctt caaagacacg
     8041 ctcggtttcc ttttccagaa ttatgggctg gtcgactcct ggaccgtccg gcagaatctg
     8101 gaagtccctc tgaagatgcg caagggtttg gcgcgtaagg attatccttc cgtctgccgg
     8161 gacgttttga aacgcgtggg cctggaagga atggaaaaag agaagatcta caccttgtcc
     8221 ggcggggagc agcagcgagt ggcccttgcc cgcctcatgc tgaagaaacc gacgatcatc
     8281 ctggccgatg aacctacatc gtccttggat gccgccaaca gccgcatggt catggaggtc
     8341 ttgcgggagt tcgccgacca gggggcgacg gtcctcatct ccacccatgg ccaggaggcc
     8401 atcgacgcct gtgacgggac cctgcggatt cccggccatg aggaagccgt ggtttaaggc
     8461 cgtccttttg cttgacctcc tcggctgaag atcccctttc ggatttcaat cccttttcgc
     8521 tgcctgtccg cgttaccgct atcgtctatc ggcagccagc ctgcttttca gctcggacag
     8581 gctctcctcc tcagcccggt ttgcggcttg atcgctggct tggtcttcga tgggcgacct
     8641 gctcaaatcc acctggtcca gggggatgag cttggtgtgg ttcttgaact tgtaagccag
     8701 gaagaggatc aaaaagaggg ggacggacat gtaggtgatg ccgatggctc gccagtccca
     8761 gacggcgaaa gagtgcaggt cctggccgat gatgaccagg atgcacagga tcagggccag
     8821 caaaggaccg aaggggaaga gcttggccct gtaacgcagt tcgctcaaac gatgcccttg
     8881 cctgaggaag gccctgcgga aacggtaatg ggagatggct atgccggccc aggctatgaa
     8941 accggtcagg ccgctggctg cgaccaggaa ggtgtagatc tcttcgccga aaatgctgga
     9001 caggaaggcc atgaaggcca cgaaggtcgt ccccagcaag gccggcaccg gaatcccgtg
     9061 gaagttgacc atgccgaaaa tccccggggc ctgcttctcc ttggccaagg cgtaaagcat
     9121 gcgggtagag gcgtacatgc ctgagttcgc cgcggacagg acggaggtga agaccaccgc
     9181 gttcatcacc ccggcggccg ccgccaagcc ggcccgttgg aagacgaggg tgaaggggga
     9241 gatggagatg tcggacgcgc tcgagccgag caggttgggt gaagtgtaag gaatcaggca
     9301 ggcgatgacg aagatggaaa ggatgtagaa gaggaggatc cgccaaaaga cctgtttgat
     9361 ggctttaggg atgcttttct ccggattagc cgattccccc gccgtgatcc cgatcagttc
     9421 cgtcccctgg aaggagaaac cggcgatggc gaaagctccg aggacggcgg ggaatccgcc
     9481 cacgaaaggg gcctttcggt aggtgaagtt ggtcagcaga ggggccttgc ctccgatgat
     9541 gccgatgatg gtcaagaggc cgatggtcag gaaaaccagg acggtgatta ctttgaccag
     9601 ggccagccag tattcggtct cgccgaaagc ccgcacggcc aggatgttga tgaggaagat
     9661 gagggacagg accaccagag agaagaccca gagggggact tgggggaacc agtagcgcag
     9721 gacgatggag ctggtggtgg tgtcgaccgc cacggtgatg gcccagttga accagtagtt
     9781 ccagcccatg gcgaaaccga gagcggggtc cacgaagcgg ctggcgtaga tggcgaagga
     9841 gccggtcgtc ggcaggtaag tggccatttc acccagggag gtcatgagga agtagaccat
     9901 gatgccgatg gccgcgtagg cgaccaaggc cccgcccggc ccggccgagt ggatggtttc
     9961 gccggatgcg atgaagaggc ccgtgccgat gcttccgccc aaggcgatca tggagacgtg
    10021 gcgggtgcgc agattgcgct tgactgtgcg cgaggctgtg cgcgagtctg tgggcgtagc
    10081 atggcctccg cccgcgggtt gcactccggt ctggctgctg ccgacgctta cttggctctg
    10141 ttgttctgtc tgcatggcat cctccgactg gtgaccgtct taccggccgt cctgtgtgtc
    10201 tttgtgcgtc tgtgtgcaga tcagaggcga atgcctaggt gataagaatc atcgaaagcg
    10261 ctccaccgtc gcaaatcgga cgacggtgac agtcctt
//
