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Overview
1.1
1.2
1.3
1.4
1.5
1.6

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP022562.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1.1 | redox-cofactor | 501,113 | 523,272 | lankacidin C | NRP + Polyketide | 13%
Region 1.2 | NAGGN | 1,472,604 | 1,487,392 |
Region 1.3 | RiPP-like | 2,268,940 | 2,279,773 |
Region 1.4 | ranthipeptide | 3,181,014 | 3,202,444 | pyoverdin | NRP | 7%
Region 1.5 | acyl_amino_acids | 3,340,398 | 3,401,327 | lysobactin | NRP | 4%
Region 1.6 | NRPS | 4,016,643 | 4,113,143 | pyoverdin | NRP | 18%

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1.1 | redox-cofactor | 501,113 | 523,272 | lankacidin C | NRP + Polyketide | 13%
Region 1.2 | NAGGN | 1,472,604 | 1,487,392 |
Region 1.3 | RiPP-like | 2,268,940 | 2,279,773 |
Region 1.4 | ranthipeptide | 3,181,014 | 3,202,444 | pyoverdin | NRP | 7%
Region 1.5 | acyl_amino_acids | 3,340,398 | 3,401,327 | lysobactin | NRP | 4%
Region 1.6 | NRPS | 4,016,643 | 4,113,143 | pyoverdin | NRP | 18%

No secondary metabolite regions were found in these records:
  NZ_CP022563.1

Compact view
NZ_CP022562.1 - Region 1 - redox-cofactor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 501,113 - 523,272 nt. (total: 22,160 nt) Show pHMM detection rules used
redox-cofactor: (cds(PF04055 and (TIGR04085 or SPASM)) and (TIGR02111 or TIGR03966) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | redox-cofactor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000258.1 |  | 0.22 | Polyketide | prodigiosin | Serratia sp.
BGC0000259.1 |  | 0.22 | Polyketide | prodigiosin | Serratia marcescens
BGC0000260.1 |  | 0.20 | Polyketide | prodigiosin | Hahella chejuensis KCTC 2396
BGC0001441.1 |  | 0.18 | Other | belactosin A, belactosin C | Streptomyces sp.
BGC0000723.1 |  | 0.17 | Saccharide | β-D-galactosylvalidoxylamine-A | Streptomyces hygroscopicus subsp. limoneus
BGC0000874.1 |  | 0.16 | Other | blasticidin S | Streptomyces griseochromogenes
BGC0001917.1 |  | 0.15 | Polyketide | 5-alkyl-1,2,3,4-tetrahydroquinolines, streptoaminals | Streptomyces nigrescens
BGC0001586.1 |  | 0.15 | Saccharide | EPS273 | Pseudomonas stutzeri
BGC0001440.1 |  | 0.15 | Other | cystargolide A, cystargolide B | Kitasatospora cystarginea
BGC0000919.1 |  | 0.15 | Other | phaseolotoxin | Pseudomonas syringae

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000258.1 |  | 0.55 | Polyketide | prodigiosin | Serratia sp.
BGC0000259.1 |  | 0.55 | Polyketide | prodigiosin | Serratia marcescens
BGC0000260.1 |  | 0.52 | Polyketide | prodigiosin | Hahella chejuensis KCTC 2396
BGC0001441.1 |  | 0.49 | Other | belactosin A, belactosin C | Streptomyces sp.
BGC0000723.1 |  | 0.48 | Saccharide | β-D-galactosylvalidoxylamine-A | Streptomyces hygroscopicus subsp. limoneus
BGC0000874.1 |  | 0.46 | Other | blasticidin S | Streptomyces griseochromogenes
BGC0001917.1 |  | 0.45 | Polyketide | 5-alkyl-1,2,3,4-tetrahydroquinolines, streptoaminals | Streptomyces nigrescens
BGC0001586.1 |  | 0.45 | Saccharide | EPS273 | Pseudomonas stutzeri
BGC0001440.1 |  | 0.44 | Other | cystargolide A, cystargolide B | Kitasatospora cystarginea
BGC0000919.1 |  | 0.44 | Other | phaseolotoxin | Pseudomonas syringae

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP022562.1 - Region 2 - NAGGN
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,472,604 - 1,487,392 nt. (total: 14,789 nt) Show pHMM detection rules used
NAGGN: ((TIGR03104 or cds(GATase_7 and Asn_synthase)) and TIGR03103 and (TIGR03106 or Peptidase_M42))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NAGGN | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000846.1 |  | 0.21 | Other | tabtoxin | Pseudomonas syringae
BGC0000937.1 |  | 0.17 | Other | fosfazinomycin A | Streptomyces sp. WM6372
BGC0000888.1 |  | 0.16 | Other | bacilysin | Bacillus sp. CS93
BGC0001184.1 |  | 0.15 | Other | bacilysin | Bacillus velezensis FZB42
BGC0001783.1 |  | 0.14 | Other | streptonigrin | Streptomyces flocculus
BGC0000781.1 |  | 0.14 | Saccharide | O-antigen | Pseudomonas aeruginosa
BGC0001140.1 |  | 0.14 | Terpene | platensimycin, platencin | Streptomyces platensis
BGC0000207.1 |  | 0.14 | Polyketide | chartreusin | Streptomyces chartreusis
BGC0001156.1 |  | 0.14 | Terpene | platencin | Streptomyces platensis
BGC0001374.1 |  | 0.14 | Other | thienodolin | Streptomyces albogriseolus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000846.1 |  | 0.54 | Other | tabtoxin | Pseudomonas syringae
BGC0000937.1 |  | 0.48 | Other | fosfazinomycin A | Streptomyces sp. WM6372
BGC0000888.1 |  | 0.47 | Other | bacilysin | Bacillus sp. CS93
BGC0001184.1 |  | 0.45 | Other | bacilysin | Bacillus velezensis FZB42
BGC0001783.1 |  | 0.44 | Other | streptonigrin | Streptomyces flocculus
BGC0000781.1 |  | 0.43 | Saccharide | O-antigen | Pseudomonas aeruginosa
BGC0001140.1 |  | 0.43 | Terpene | platensimycin, platencin | Streptomyces platensis
BGC0000207.1 |  | 0.43 | Polyketide | chartreusin | Streptomyces chartreusis
BGC0001156.1 |  | 0.43 | Terpene | platencin | Streptomyces platensis
BGC0001374.1 |  | 0.43 | Other | thienodolin | Streptomyces albogriseolus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP022562.1 - Region 3 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,268,940 - 2,279,773 nt. (total: 10,834 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000928.1 |  | 0.16 | Other | T3 toxin | Cylindrospermopsis raciborskii T3
BGC0000188.1 |  | 0.16 | Alkaloid | saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2 | Cylindrospermopsis raciborskii T3
BGC0000883.1 |  | 0.14 | Other | arginomycin | Streptomyces arginensis
BGC0000043.1 |  | 0.12 | Polyketide | curacin A | Moorea producens 19L
BGC0000527.1 |  | 0.09 | RiPP | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0000547.1 |  | 0.09 | RiPP | salivaricin 9 | Streptococcus salivarius
BGC0001789.1 |  | 0.09 | RiPP | suicin 90-1330 | Streptococcus suis
BGC0000536.1 |  | 0.09 | RiPP | nisin Q | Lactococcus lactis
BGC0000537.1 |  | 0.08 | RiPP | nisin U | Streptococcus uberis
BGC0000515.1 |  | 0.08 | RiPP | geobacillin I | Geobacillus thermodenitrificans NG80-2

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000928.1 |  | 0.47 | Other | T3 toxin | Cylindrospermopsis raciborskii T3
BGC0000188.1 |  | 0.47 | Alkaloid | saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2 | Cylindrospermopsis raciborskii T3
BGC0000883.1 |  | 0.44 | Other | arginomycin | Streptomyces arginensis
BGC0000043.1 |  | 0.39 | Polyketide | curacin A | Moorea producens 19L
BGC0000527.1 |  | 0.33 | RiPP | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0000547.1 |  | 0.32 | RiPP | salivaricin 9 | Streptococcus salivarius
BGC0001789.1 |  | 0.32 | RiPP | suicin 90-1330 | Streptococcus suis
BGC0000536.1 |  | 0.32 | RiPP | nisin Q | Lactococcus lactis
BGC0000537.1 |  | 0.32 | RiPP | nisin U | Streptococcus uberis
BGC0000515.1 |  | 0.30 | RiPP | geobacillin I | Geobacillus thermodenitrificans NG80-2

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
NZ_CP022562.1 - Region 4 - ranthipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,181,014 - 3,202,444 nt. (total: 21,431 nt) Show pHMM detection rules used
ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or YcaO or TIGR03882)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | ranthipeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001733.1 |  | 0.19 | RiPP | PcpA | Pleurocapsa sp. PCC 7327
BGC0000938.1 |  | 0.17 | Other (Aminocoumarin) | fosfomycin | Streptomyces fradiae
BGC0000551.1 |  | 0.16 | RiPP | SapB | Streptomyces coelicolor A3(2)
BGC0001551.1 |  | 0.16 | RiPP | citrulassin E | Streptomyces glaucescens
BGC0000519.1 |  | 0.16 | RiPP | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0001526.1 |  | 0.16 | Other | bartolosides E, bartolosides F, bartolosides G, bartolosides H, bartolosides I, bartolosides J, bartolosides K | Synechocystis salina LEGE 06099
BGC0000487.1 |  | 0.16 | RiPP | carnocyclin | Carnobacterium maltaromaticum
BGC0000501.1 |  | 0.16 | RiPP | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0001897.1 |  | 0.16 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10
BGC0001928.1 |  | 0.16 | Other | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001733.1 |  | 0.51 | RiPP | PcpA | Pleurocapsa sp. PCC 7327
BGC0000938.1 |  | 0.48 | Other (Aminocoumarin) | fosfomycin | Streptomyces fradiae
BGC0000551.1 |  | 0.47 | RiPP | SapB | Streptomyces coelicolor A3(2)
BGC0001551.1 |  | 0.47 | RiPP | citrulassin E | Streptomyces glaucescens
BGC0000519.1 |  | 0.47 | RiPP | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0001526.1 |  | 0.47 | Other | bartolosides E, bartolosides F, bartolosides G, bartolosides H, bartolosides I, bartolosides J, bartolosides K | Synechocystis salina LEGE 06099
BGC0000487.1 |  | 0.46 | RiPP | carnocyclin | Carnobacterium maltaromaticum
BGC0000501.1 |  | 0.46 | RiPP | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0001897.1 |  | 0.46 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10
BGC0001928.1 |  | 0.46 | Other | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP022562.1 - Region 5 - acyl_amino_acids
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,340,398 - 3,401,327 nt. (total: 60,930 nt) Show pHMM detection rules used
acyl_amino_acids: NasY

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | acyl_amino_acids | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000929.1 |  | 0.19 | Other | xanthothricin | Burkholderia glumae
BGC0001512.1 |  | 0.17 | Polyketide | BE-24566B | Streptomyces sp.
BGC0001526.1 |  | 0.17 | Other | bartolosides E, bartolosides F, bartolosides G, bartolosides H, bartolosides I, bartolosides J, bartolosides K | Synechocystis salina LEGE 06099
BGC0000487.1 |  | 0.17 | RiPP | carnocyclin | Carnobacterium maltaromaticum
BGC0000938.1 |  | 0.17 | Other (Aminocoumarin) | fosfomycin | Streptomyces fradiae
BGC0001525.1 |  | 0.17 | Other | bartoloside 2, bartoloside 3, bartoloside 4 | Synechocystis salina LEGE 06155
BGC0000529.1 |  | 0.17 | RiPP | microbisporicin A2 | Microbispora corallina
BGC0000554.1 |  | 0.17 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001343.1 |  | 0.17 | Polyketide | aurachin A, aurachin D | Stigmatella aurantiaca Sg a15
BGC0001964.1 |  | 0.16 | Polyketide | alkylpyrone-407, alkylpyrone-393 | Cystobacterineae bacterium

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000929.1 |  | 0.51 | Other | xanthothricin | Burkholderia glumae
BGC0001512.1 |  | 0.49 | Polyketide | BE-24566B | Streptomyces sp.
BGC0001526.1 |  | 0.48 | Other | bartolosides E, bartolosides F, bartolosides G, bartolosides H, bartolosides I, bartolosides J, bartolosides K | Synechocystis salina LEGE 06099
BGC0000487.1 |  | 0.48 | RiPP | carnocyclin | Carnobacterium maltaromaticum
BGC0000938.1 |  | 0.48 | Other (Aminocoumarin) | fosfomycin | Streptomyces fradiae
BGC0001525.1 |  | 0.48 | Other | bartoloside 2, bartoloside 3, bartoloside 4 | Synechocystis salina LEGE 06155
BGC0000529.1 |  | 0.48 | RiPP | microbisporicin A2 | Microbispora corallina
BGC0000554.1 |  | 0.48 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001343.1 |  | 0.48 | Polyketide | aurachin A, aurachin D | Stigmatella aurantiaca Sg a15
BGC0001964.1 |  | 0.47 | Polyketide | alkylpyrone-407, alkylpyrone-393 | Cystobacterineae bacterium

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP022562.1 - Region 6 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,016,643 - 4,113,143 nt. (total: 96,501 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000426.1 |  | 0.38 | NRP | sevadicin | Paenibacillus larvae
BGC0000389.1 |  | 0.36 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0001767.1 |  | 0.35 | NRP | salinichelins | Salinispora pacifica CNY331
BGC0001758.1 |  | 0.34 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001844.1 |  | 0.34 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0000463.1 |  | 0.34 | NRP | xantholysin A, xantholysin B, xantholysin C | Pseudomonas putida
BGC0001131.1 |  | 0.34 | NRP | ambactin | Xenorhabdus miraniensis
BGC0001434.1 |  | 0.33 | NRP | nematophin | Xenorhabdus budapestensis
BGC0001698.1 |  | 0.33 | NRP | nevaltophin A, nevaltophin B, nevaltophin C, nevaltophin D | Xenorhabdus budapestensis
BGC0000410.1 |  | 0.33 | NRP | pseudomonine | Pseudomonas fluorescens

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000426.1 |  | 0.71 | NRP | sevadicin | Paenibacillus larvae
BGC0000389.1 |  | 0.69 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0001767.1 |  | 0.68 | NRP | salinichelins | Salinispora pacifica CNY331
BGC0001758.1 |  | 0.67 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001844.1 |  | 0.67 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0000463.1 |  | 0.67 | NRP | xantholysin A, xantholysin B, xantholysin C | Pseudomonas putida
BGC0001131.1 |  | 0.67 | NRP | ambactin | Xenorhabdus miraniensis
BGC0001434.1 |  | 0.67 | NRP | nematophin | Xenorhabdus budapestensis
BGC0001698.1 |  | 0.67 | NRP | nevaltophin A, nevaltophin B, nevaltophin C, nevaltophin D | Xenorhabdus budapestensis
BGC0000410.1 |  | 0.67 | NRP | pseudomonine | Pseudomonas fluorescens

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 6, location 4016642 - 4113143:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (glu - D-X - X) + (asp - X - D-X - ala) + (ser) + (D-ser - gly) + (D-ser - D-lys)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_3734: ser - lys
  Search NORINE for peptide: strict or relaxed
  AMP-binding (515..917): ser
  NRPSPredictor2: ser
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      ser
    Single AA prediction:
      ser
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVWHVSLIDK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      100% (strong)
  AMP-binding (2014..2412): lys
  NRPSPredictor2: lys
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      orn, lys, arg
    Small clusters prediction:
      glu, gln
    Single AA prediction:
      lys
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DgeccGGVtK
    Nearest Stachelhaus code:
      leu
    Stachelhaus code match:
      50% (weak)
ctg1_3735: ser - gly
  Search NORINE for peptide: strict or relaxed
  AMP-binding (509..906): ser
  NRPSPredictor2: ser
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      ser
    Single AA prediction:
      ser
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVWHVSLIDK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      100% (strong)
  AMP-binding (2027..2425): gly
  NRPSPredictor2: gly
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      gly, ala
    Single AA prediction:
      gly
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DILQiGLIWK
    Nearest Stachelhaus code:
      gly
    Stachelhaus code match:
      90% (moderate)
ctg1_3736: ser
  Search NORINE for peptide: strict or relaxed
  AMP-binding (514..912): ser
  NRPSPredictor2: ser
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      ser
    Single AA prediction:
      ser
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVWHVSLIDK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      100% (strong)
ctg1_3737: asp - X - X - ala
  Search NORINE for peptide: strict or relaxed
  AMP-binding (527..898): asp
  NRPSPredictor2: asp
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      asp, asn
    Single AA prediction:
      asp
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLTKVGHVGK
    Nearest Stachelhaus code:
      asp
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1557..1965): X
  NRPSPredictor2: asp, asn, glu, gln, aad
  SVM prediction details:
    Predicted physicochemical class:
      N/A
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DGedhGtVVK
    Nearest Stachelhaus code:
      leu
    Stachelhaus code match:
      60% (weak)
  AMP-binding (2625..3027): X
  NRPSPredictor2: orn, lys, arg
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      orn, lys, arg
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DghVcGgVtK
    Nearest Stachelhaus code:
      phe
    Stachelhaus code match:
      50% (weak)
  AMP-binding (4146..4537): ala
  NRPSPredictor2: ala
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      gly, ala
    Single AA prediction:
      ala
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLwNNALTYK
    Nearest Stachelhaus code:
      ala
    Stachelhaus code match:
      90% (moderate)
ctg1_3746: pk - glu - X - X
  Search NORINE for peptide: strict or relaxed
  CAL_domain (41..482): pk
  minowa: NH2
  Prediction, score:
    NH2: 163.7
    Acetyl-CoA: 49.7
    AHBA: 16.8
    fatty_acid: 14.4
    shikimic_acid: -2.8
  AMP-binding (1131..1528): glu
  NRPSPredictor2: glu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      glu, gln
    Single AA prediction:
      glu
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVWHFGRINK
    Nearest Stachelhaus code:
      glu
    Stachelhaus code match:
      100% (strong)
  AMP-binding (2182..2586): X
  NRPSPredictor2: hydrophilic
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAegiGAVMK
    Nearest Stachelhaus code:
      phe
    Stachelhaus code match:
      70% (weak)
  AMP-binding (3708..4114): X
  NRPSPredictor2: asp, asn, glu, gln, aad
  SVM prediction details:
    Predicted physicochemical class:
      N/A
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DiWeLtadDK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      50% (weak)