LOCUS       c00081_NZ_WSRS..       16594 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_WSRS01000027.1 Streptococcus danieliae strain NM51_B2-22
            NODE_27_length_19546_cov_62.0718, whole genome shotgun sequence.
ACCESSION   NZ_WSRS01000027
VERSION     NZ_WSRS01000027
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 15:43:44
            Original ID  :: NZ_WSRS01000027.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16594
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16594
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[3846:6594]"
                     /cutoff="5000"
                     /detection_rule="(PF04055 and TIGR01716)"
                     /neighbourhood="10000"
                     /product="RaS-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3847..6594
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="(PF04055 and TIGR01716)"
                     /neighbourhood="10000"
                     /product="RaS-RiPP"
                     /protocluster_number="1"
     cand_cluster    1..16594
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PF04055 and TIGR01716)"
                     /kind="single"
                     /product="RaS-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..16594
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RaS-RiPP"
                     /region_number="1"
                     /rules="(PF04055 and TIGR01716)"
                     /tool="antismash"
     CDS             complement(2..82)
                     /locus_tag="ctg81_1"
                     /transl_table=11
                     /translation="MYIHYNTNQTTLPLEIASVLPQDHIVF"
     CDS             complement(378..2003)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg81_2"
                     /sec_met_domain="Polysacc_synt (E-value: 1.1e-27, bitscore:
                     87.6, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNDQQARQQELMLKGAAWMTASNLISRLLGALYIIPWYGWMGAHA
                     AEANGLFTMGYNIYAWFLLVSTAGLPVAISKQIAKYNTMGQEDKSFALINRFLKLMVIL
                     GLVFAALMYLAAPLFASGSGVGAELTPVMQSLAWAVLIFPAMSIIRGVFQGYSNMRPYA
                     MSQIAEQVARVIWMLLATFLIMQLGNKDYVSAVTQSTLAAFIGMLASMALLIFLLNQEG
                     LLRPILAASGQKLEGGSQLVLETLKEAIPFIITGSAIQLFQIIDQMTFINVSRWFTKTS
                     ETELLVLFSYFSANPNKVSMILIAVASSVGGVGIPLLTENYVKKDLAAAAKLVIDNLSL
                     LLTFLIPATLGSLLMGRALYTFFYGQPEGAALDLFVWAMSFTLLLGLYTVLAPMIQALY
                     QNRLAMLYFLYGLGAKLVLQIPFIWIFGSYGPLLSTGVALVLPCFLMYRTIHQVTRLNH
                     KRLMKRVVLVTLMTLIMSLVTMLAQALLSLVIGVNSRWGSLLHLMIVGAISVYVYAWMA
                     LKSNHLDRVMGSQANRLRRLLRIS"
     PFAM_domain     complement(444..881)
                     /aSDomain="Polysacc_synt_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF14667.8"
                     /description="Polysaccharide biosynthesis C-terminal
                     domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg81_2_0002"
                     /evalue="5.30E-19"
                     /label="ctg81_2"
                     /locus_tag="ctg81_2"
                     /protein_end="520"
                     /protein_start="374"
                     /score="68.8"
                     /tool="antismash"
                     /translation="FVWAMSFTLLLGLYTVLAPMIQALYQNRLAMLYFLYGLGAKLVLQ
                     IPFIWIFGSYGPLLSTGVALVLPCFLMYRTIHQVTRLNHKRLMKRVVLVTLMTLIMSLV
                     TMLAQALLSLVIGVNSRWGSLLHLMIVGAISVYVYAWMALKS"
     PFAM_domain     complement(1044..1967)
                     /aSDomain="Polysacc_synt"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01943.19"
                     /description="Polysaccharide biosynthesis protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg81_2_0001"
                     /evalue="1.10E-29"
                     /label="ctg81_2"
                     /locus_tag="ctg81_2"
                     /protein_end="320"
                     /protein_start="12"
                     /score="103.7"
                     /tool="antismash"
                     /translation="LKGAAWMTASNLISRLLGALYIIPWYGWMGAHAAEANGLFTMGYN
                     IYAWFLLVSTAGLPVAISKQIAKYNTMGQEDKSFALINRFLKLMVILGLVFAALMYLAA
                     PLFASGSGVGAELTPVMQSLAWAVLIFPAMSIIRGVFQGYSNMRPYAMSQIAEQVARVI
                     WMLLATFLIMQLGNKDYVSAVTQSTLAAFIGMLASMALLIFLLNQEGLLRPILAASGQK
                     LEGGSQLVLETLKEAIPFIITGSAIQLFQIIDQMTFINVSRWFTKTSETELLVLFSYFS
                     ANPNKVSMILIAVASSVGGVGIPLLTE"
     CDS             2362..3807
                     /locus_tag="ctg81_3"
                     /transl_table=11
                     /translation="MKLETALQILQADHNFRAIVDQDTFHYRGHDWTFQELSYDSRQVS
                     EHTLFFAKGQQFKAEYLEAAIQQGLRYYVSEIDYQVAIPVILVNDIKQAMSLIAMEFYQ
                     HPEKKLKLLAFTGTKGKTTAAYFAFNILKQEWKPAMLSTMNSTLDGVHFFKSQLTTPES
                     LDLFAMMAEAVAHGRTHFIMEVSSQAYLVKRVYGLTFDVGVFLNISPDHIGPIEHPSYE
                     DYFYHKRQLLANSRFLILNQQMDHSDFLLDSIQDQPHTTYGLGSPNTIEESAAFHFKVG
                     GPLAGDYDIQLIGDFNQENALAAGLACQQLEASPAAIQAGIAQTKVDGRMEVLTHPSGA
                     KIFIDYAHNGDSLKKLIDTVAHYQKGKLALILGATGNKGENRRKDFGLLLNDYPDLEVV
                     LTADDPNYEDPVAISQEIASYLHRPVTIIADRETAIQEILSQQYQSEDAIIIAGKGADA
                     FQIVQGEKIPYPGDPQVVVQALE"
     aSDomain        2458..3801
                     /aSDomain="TIGR01085"
                     /aSTool="tigrfam"
                     /description="murE: UDP-N-acetylmuramyl-tripeptide
                     synthetase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg81_3_0001"
                     /evalue="1.20E-86"
                     /identifier="TIGR01085"
                     /label="ctg81_3"
                     /locus_tag="ctg81_3"
                     /protein_end="480"
                     /protein_start="32"
                     /score="289.4"
                     /tool="antismash"
                     /translation="TFQELSYDSRQVSEHTLFFAKGQQFKAEYLEAAIQQGLRYYVSEI
                     DYQVAIPVILVNDIKQAMSLIAMEFYQHPEKKLKLLAFTGTKGKTTAAYFAFNILKQEW
                     KPAMLSTMNSTLDGVHFFKSQLTTPESLDLFAMMAEAVAHGRTHFIMEVSSQAYLVKRV
                     YGLTFDVGVFLNISPDHIGPIEHPSYEDYFYHKRQLLANSRFLILNQQMDHSDFLLDSI
                     QDQPHTTYGLGSPNTIEESAAFHFKVGGPLAGDYDIQLIGDFNQENALAAGLACQQLEA
                     SPAAIQAGIAQTKVDGRMEVLTHPSGAKIFIDYAHNGDSLKKLIDTVAHYQKGKLALIL
                     GATGNKGENRRKDFGLLLNDYPDLEVVLTADDPNYEDPVAISQEIASYLHRPVTIIADR
                     ETAIQEILSQQYQSEDAIIIAGKGADAFQIVQGEKIPYPGDPQVVVQAL"
     PFAM_domain     2707..3282
                     /aSDomain="Mur_ligase_M"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF08245.14"
                     /description="Mur ligase middle domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg81_3_0003"
                     /evalue="1.90E-33"
                     /label="ctg81_3"
                     /locus_tag="ctg81_3"
                     /protein_end="307"
                     /protein_start="115"
                     /score="116.2"
                     /tool="antismash"
                     /translation="TGTKGKTTAAYFAFNILKQEWKPAMLSTMNSTLDGVHFFKSQLTT
                     PESLDLFAMMAEAVAHGRTHFIMEVSSQAYLVKRVYGLTFDVGVFLNISPDHIGPIEHP
                     SYEDYFYHKRQLLANSRFLILNQQMDHSDFLLDSIQDQPHTTYGLGSPNTIEESAAFHF
                     KVGGPLAGDYDIQLIGDFNQENALAAGLA"
     PFAM_domain     3340..3597
                     /aSDomain="Mur_ligase_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02875.23"
                     /description="Mur ligase family, glutamate ligase domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg81_3_0004"
                     /evalue="1.60E-15"
                     /label="ctg81_3"
                     /locus_tag="ctg81_3"
                     /protein_end="412"
                     /protein_start="326"
                     /score="57.2"
                     /tool="antismash"
                     /translation="VDGRMEVLTHPSGAKIFIDYAHNGDSLKKLIDTVAHYQKGKLALI
                     LGATGNKGENRRKDFGLLLNDYPDLEVVLTADDPNYEDPVA"
     CDS             complement(3847..4719)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RaS-RiPP: TIGR01716"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg81_4"
                     /sec_met_domain="TIGR01716 (E-value: 1.4e-46, bitscore:
                     149.3, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSFGKVFKQFRQSRGLSLRSIATKDLSVSQLSRFENGQSDLTIS
                     KFKIALDEINMPMSEFLYAVQDFKRDELQELLHQMDIYVLQNDVVSMRHLLESRPVKPR
                     LRRLFYELNTIIIKIKLEEMTGDPVVSERDLSVLTDYLIGVEYWGYYELLLFTHSMHRF
                     RHALFMTLSKEMISRSEFYKELPLNRRMINYLVLEAFVLSCERQELIDAQYYRKFIKNH
                     HFEERDMFERMVVQYGEGMFEFFFHDERKGLMQMEAVIESFRALGSIHLAQSYENRVRA
                     AQKIKATKN"
     aSDomain        complement(3871..4533)
                     /aSDomain="TIGR01716"
                     /aSTool="tigrfam"
                     /description="RGG_Cterm: transcriptional activator,
                     Rgg/GadR/MutR family, C-terminal domain"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg81_4_0002"
                     /evalue="3.00E-44"
                     /identifier="TIGR01716"
                     /label="ctg81_4"
                     /locus_tag="ctg81_4"
                     /protein_end="283"
                     /protein_start="62"
                     /score="149.3"
                     /tool="antismash"
                     /translation="YAVQDFKRDELQELLHQMDIYVLQNDVVSMRHLLESRPVKPRLRR
                     LFYELNTIIIKIKLEEMTGDPVVSERDLSVLTDYLIGVEYWGYYELLLFTHSMHRFRHA
                     LFMTLSKEMISRSEFYKELPLNRRMINYLVLEAFVLSCERQELIDAQYYRKFIKNHHFE
                     ERDMFERMVVQYGEGMFEFFFHDERKGLMQMEAVIESFRALGSIHLAQSYENRVRAAQ"
     PFAM_domain     complement(4537..4695)
                     /aSDomain="HTH_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01381.24"
                     /description="Helix-turn-helix"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg81_4_0005"
                     /evalue="3.80E-05"
                     /label="ctg81_4"
                     /locus_tag="ctg81_4"
                     /protein_end="61"
                     /protein_start="8"
                     /score="23.7"
                     /tool="antismash"
                     /translation="KQFRQSRGLSLRSIATKDLSVSQLSRFENGQSDLTISKFKIALDE
                     INMPMSEF"
     CDS             complement(4787..5722)
                     /locus_tag="ctg81_5"
                     /transl_table=11
                     /translation="MSKILVFGHQNPDTDAIASSYAYAYLARQAHGLDTEAVILGQPNE
                     ETRFVLDYFGVETPREIQSLAQEGVEQVILTDHNEFQQSAEGIRDVEVFGVVDHHRVAN
                     FETANPLFMRLEPVGSASSIVYRMFKENQVQVPKELAGLMLSGLISDTLLLKSPTTHVT
                     DVPLAAELAELAGVDLEAYGLEMLKAGTNLSSKTAAELIDIDAKSFELGGNTVRVAQVN
                     TVDIAEILERQAEIEEAMQAAMAEAGYSDFVLMITDIVNSNSEILTLGANPDKVEAAFG
                     FTLENHHAFLPGAVSRKKQVVPQLTAAFAN"
     PFAM_domain     complement(4799..5170)
                     /aSDomain="DHHA2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02833.16"
                     /description="DHHA2 domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg81_5_0007"
                     /evalue="4.80E-20"
                     /label="ctg81_5"
                     /locus_tag="ctg81_5"
                     /protein_end="308"
                     /protein_start="184"
                     /score="72.3"
                     /tool="antismash"
                     /translation="EMLKAGTNLSSKTAAELIDIDAKSFELGGNTVRVAQVNTVDIAEI
                     LERQAEIEEAMQAAMAEAGYSDFVLMITDIVNSNSEILTLGANPDKVEAAFGFTLENHH
                     AFLPGAVSRKKQVVPQLTAA"
     PFAM_domain     complement(5282..5716)
                     /aSDomain="DHH"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01368.22"
                     /description="DHH family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg81_5_0006"
                     /evalue="3.70E-26"
                     /label="ctg81_5"
                     /locus_tag="ctg81_5"
                     /protein_end="147"
                     /protein_start="2"
                     /score="91.8"
                     /tool="antismash"
                     /translation="KILVFGHQNPDTDAIASSYAYAYLARQAHGLDTEAVILGQPNEET
                     RFVLDYFGVETPREIQSLAQEGVEQVILTDHNEFQQSAEGIRDVEVFGVVDHHRVANFE
                     TANPLFMRLEPVGSASSIVYRMFKENQVQVPKELAGLMLSG"
     CDS             complement(5800..6594)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RaS-RiPP: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg81_6"
                     /sec_met_domain="PF04055 (E-value: 2.3e-33, bitscore:
                     106.4, seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 1.4e-19, bitscore: 61.3,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGQVIDYGQVTGYVHSTESFGAVDGPGIRFIVFLQGCKMRCQYCH
                     NPDTWAFENEQAQTRTVDDILKEALRYRGYWGKNGGITVSGGEALLQIDFLIALFTKAK
                     ELGIHTTLDTCALPFRNKPEYLEVFDRLMAVTDLVLLDIKEINDERHKFVTSQSNRNIL
                     DCARYLSDKGIPVWIRHVLVPGLTDHDEDLKELGEFVKTLKNVDKFEILPYHTMGEFKW
                     EKLGIDYPLKGVKPPTKERVANAKKLMETESYQDYLKRVQKG"
     aSDomain        complement(5842..6558)
                     /aSDomain="TIGR02493"
                     /aSTool="tigrfam"
                     /description="PFLA: pyruvate formate-lyase 1-activating
                     enzyme"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg81_6_0003"
                     /evalue="5.10E-96"
                     /identifier="TIGR02493"
                     /label="ctg81_6"
                     /locus_tag="ctg81_6"
                     /protein_end="251"
                     /protein_start="12"
                     /score="318.5"
                     /tool="antismash"
                     /translation="YVHSTESFGAVDGPGIRFIVFLQGCKMRCQYCHNPDTWAFENEQA
                     QTRTVDDILKEALRYRGYWGKNGGITVSGGEALLQIDFLIALFTKAKELGIHTTLDTCA
                     LPFRNKPEYLEVFDRLMAVTDLVLLDIKEINDERHKFVTSQSNRNILDCARYLSDKGIP
                     VWIRHVLVPGLTDHDEDLKELGEFVKTLKNVDKFEILPYHTMGEFKWEKLGIDYPLKGV
                     KPPTKERVANAKKLMET"
     PFAM_domain     complement(6016..6504)
                     /aSDomain="Radical_SAM"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04055.23"
                     /description="Radical SAM superfamily"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg81_6_0008"
                     /evalue="3.00E-30"
                     /label="ctg81_6"
                     /locus_tag="ctg81_6"
                     /protein_end="193"
                     /protein_start="30"
                     /score="105.9"
                     /tool="antismash"
                     /translation="IVFLQGCKMRCQYCHNPDTWAFENEQAQTRTVDDILKEALRYRGY
                     WGKNGGITVSGGEALLQIDFLIALFTKAKELGIHTTLDTCALPFRNKPEYLEVFDRLMA
                     VTDLVLLDIKEINDERHKFVTSQSNRNILDCARYLSDKGIPVWIRHVLVPGLTDHDEDL
                     "
     CDS             complement(6765..8108)
                     /gene_functions="other (smcogs) SMCOG1273:hypothetical
                     protein (Score: 483.3; E-value: 1.1e-146)"
                     /gene_kind="other"
                     /locus_tag="ctg81_7"
                     /transl_table=11
                     /translation="MEDPSSQNLVVQIVLLFFLTFLNAFFSASEMAMVSLNRSRVEQKA
                     GEGDRAYQRLLNVLEEPNHFLSTIQVGITLINILAGASLADTLGRMFATWMGGGETAYA
                     VGSLLALALLTYISIVLGELYPKRIALNLKESLAVRTAPIILFLGKIVSPFVWLLSAST
                     NLLSRLTPMEFDDADEKMTRDEIEYMLSKSEESLDAEELEMLQGVFTLDELMARELMVP
                     RTDAFMVDIKNASEENIQAILKQNFSRIPVYEGDKDNIIGILHTKRILTEAFTAGFENL
                     SLEKILQEPLFVPETMFVDDLLASLRNTQNQMAILLDEYGGVAGLVTLEDLLEEIVGEI
                     EDETDKAELEVRELADGSYIVLGAMTLNDFNEHFDVELASDDVDTIAGYYITTLGSIPT
                     EGERLSVDLESNGYRLTLRNDKVKRGRVTKLRLHIDKIQEDLEETTSK"
     PFAM_domain     complement(6807..7052)
                     /aSDomain="CorC_HlyC"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03471.19"
                     /description="Transporter associated domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg81_7_0011"
                     /evalue="2.10E-19"
                     /label="ctg81_7"
                     /locus_tag="ctg81_7"
                     /protein_end="434"
                     /protein_start="352"
                     /score="69.4"
                     /tool="antismash"
                     /translation="ELADGSYIVLGAMTLNDFNEHFDVELASDDVDTIAGYYITTLGSI
                     PTEGERLSVDLESNGYRLTLRNDKVKRGRVTKLRLHI"
     PFAM_domain     complement(7098..7244)
                     /aSDomain="CBS"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00571.30"
                     /description="CBS domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg81_7_0010"
                     /evalue="5.80E-05"
                     /label="ctg81_7"
                     /locus_tag="ctg81_7"
                     /protein_end="337"
                     /protein_start="288"
                     /score="23.6"
                     /tool="antismash"
                     /translation="EPLFVPETMFVDDLLASLRNTQNQMAILLDEYGGVAGLVTLEDLL
                     EEIV"
     PFAM_domain     complement(7509..8066)
                     /aSDomain="DUF21"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01595.22"
                     /description="Cyclin M transmembrane N-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg81_7_0009"
                     /evalue="2.60E-48"
                     /label="ctg81_7"
                     /locus_tag="ctg81_7"
                     /protein_end="200"
                     /protein_start="14"
                     /score="164.1"
                     /tool="antismash"
                     /translation="LLFFLTFLNAFFSASEMAMVSLNRSRVEQKAGEGDRAYQRLLNVL
                     EEPNHFLSTIQVGITLINILAGASLADTLGRMFATWMGGGETAYAVGSLLALALLTYIS
                     IVLGELYPKRIALNLKESLAVRTAPIILFLGKIVSPFVWLLSASTNLLSRLTPMEFDDA
                     DEKMTRDEIEYMLSKSEESLDAE"
     CDS             complement(8224..9363)
                     /locus_tag="ctg81_8"
                     /transl_table=11
                     /translation="MKNGLLKVVYTLVLLGAAFWWGLRFGALLAQVYVGPSWNNVWLET
                     LFESTFLILLHLPLYLLVVLLHEFGHLLGGLWSGYHFVSFRVGNRVLVRWDEGLVWKRF
                     SLMGTGGQCIMVPPVRSDDQFPFLRYHLGGPLMNLLLSLVFFLALEMQPSVWTLLLWSF
                     GGLNLLSALANGIPWKGKVVANDGWNAWNLSKNPAEREVFAKQMLILEAMTRGQQLRAL
                     PADWFRIESESRSENSSAASLAFTRAQYMIDKGEEQAGIDLLQSLLESKSSVPSFERTT
                     MQLFKLYYDLLTEAGSVDLSVLDDKETQQFLKGMKDYPFVLSLNYALARLSKQDQVEAA
                     RIRQRLDRVLETYPTKAEIDSVWEDLELIDRIAAGQPLD"
     PFAM_domain     complement(8908..9183)
                     /aSDomain="Peptidase_M50"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02163.24"
                     /description="Peptidase family M50"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg81_8_0012"
                     /evalue="9.30E-07"
                     /label="ctg81_8"
                     /locus_tag="ctg81_8"
                     /protein_end="152"
                     /protein_start="60"
                     /score="28.5"
                     /tool="antismash"
                     /translation="LLVVLLHEFGHLLGGLWSGYHFVSFRVGNRVLVRWDEGLVWKRFS
                     LMGTGGQCIMVPPVRSDDQFPFLRYHLGGPLMNLLLSLVFFLALEMQ"
     CDS             complement(9383..9913)
                     /locus_tag="ctg81_9"
                     /transl_table=11
                     /translation="MVSLAERYADYPVQPFISEQQALDHAQGKVAPAVPRKNMELLEGE
                     ILAGDVILLWRIALGTFTTESVFPKYFEYTYGIDAPHNLQVLEERGLVRQQKARESLAH
                     INAGQKKAILKNQGVKGFSKMKAAELDQALLDQVEDQALEASFDIRGYCLTAQGQALFD
                     QHTEVLDRHPKKG"
     CDS             complement(9915..10331)
                     /locus_tag="ctg81_10"
                     /transl_table=11
                     /translation="MIKRMEVYLVTDGNGQEAVEFYKGVLGAEVTSLTLWGDAIPDVAD
                     EHKHLVLNAQLVVDGIRLQISDESPEYSYAPGRNVVPSIIVDSVVAAQKLYDALKEEAQ
                     EVTLELQETFWSPAYANLIDRYGINWQISAEVEG"
     PFAM_domain     complement(9936..10310)
                     /aSDomain="Glyoxalase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00903.27"
                     /description="Glyoxalase/Bleomycin resistance
                     protein/Dioxygenase superfamily"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg81_10_0013"
                     /evalue="4.10E-06"
                     /label="ctg81_10"
                     /locus_tag="ctg81_10"
                     /protein_end="132"
                     /protein_start="7"
                     /score="27.1"
                     /tool="antismash"
                     /translation="YLVTDGNGQEAVEFYKGVLGAEVTSLTLWGDAIPDVADEHKHLVL
                     NAQLVVDGIRLQISDESPEYSYAPGRNVVPSIIVDSVVAAQKLYDALKEEAQEVTLELQ
                     ETFWSPAYANLIDRYGINWQI"
     CDS             complement(10328..10621)
                     /locus_tag="ctg81_11"
                     /transl_table=11
                     /translation="LVECQESRGIVSDLWILKKDGQLKSVFQDQVKVAELNPELDLGRP
                     SFLMEYSDLDATYPFMLDRGILVMPIVDLDLMRVFNFSDLEENYFAIREVKK"
     CDS             10785..11522
                     /locus_tag="ctg81_12"
                     /transl_table=11
                     /translation="MKKLLIAGLLASAATLALIIYQNQPKQELSLNAQLQEVLKNPETD
                     FPQLTTKASKQEPIVTLKTSQGDISLKLFPEYAPLAVENFLTHAKEGYYDGLSFHRVIK
                     DFMIQTGDPKGDGSGGESIWAGKDNEKDPGTGFKNEISPYLYNIRGAVSMANAGPDTNG
                     SQFFINQNTQDISSRLDPNTYHPKIIQAYQKGGNPSLDGSYTVFGQVTQGMEVVDKIAA
                     TETDDKDKPKEAITIQKITIQSE"
     PFAM_domain     10962..11507
                     /aSDomain="Pro_isomerase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00160.23"
                     /description="Cyclophilin type peptidyl-prolyl cis-trans
                     isomerase/CLD"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg81_12_0014"
                     /evalue="5.80E-52"
                     /label="ctg81_12"
                     /locus_tag="ctg81_12"
                     /protein_end="241"
                     /protein_start="59"
                     /score="176.2"
                     /tool="antismash"
                     /translation="VTLKTSQGDISLKLFPEYAPLAVENFLTHAKEGYYDGLSFHRVIK
                     DFMIQTGDPKGDGSGGESIWAGKDNEKDPGTGFKNEISPYLYNIRGAVSMANAGPDTNG
                     SQFFINQNTQDISSRLDPNTYHPKIIQAYQKGGNPSLDGSYTVFGQVTQGMEVVDKIAA
                     TETDDKDKPKEAITIQKIT"
     CDS             11592..12518
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039:aldo/keto reductase family oxidoreductase (Score:
                     201.7; E-value: 2.5e-61)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg81_13"
                     /transl_table=11
                     /translation="MKTIELNSENTKLSSIVLGLMRIKSLSPREVEELVETALAAGINT
                     FDLADIYGGGRSEEILGQVLKTRPDLRDQMWIQSKCGIRIEEFTYFDFSKEHILKSVDG
                     ILKRLHIQQLDSLLLHRPDALMEPEEVAEAFNHLEKTGKVRNFGVSNQNPMMIELLKTA
                     VSQPLAINQLQLSAAFTPEFDTGFHVNMEEAIASSGPTGIFEYARAKDMVIQAWSVLQY
                     GYFQGVFLGNPQFEKLNQVLTRLAQNYQTTPSAIAIAWVLRYPAKMQAIIGTTQPQRIL
                     EAAQASTITLSRKEWYEIYLAAGKSLP"
     PFAM_domain     11637..12488
                     /aSDomain="Aldo_ket_red"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00248.23"
                     /description="Aldo/keto reductase family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg81_13_0015"
                     /evalue="2.00E-50"
                     /label="ctg81_13"
                     /locus_tag="ctg81_13"
                     /protein_end="299"
                     /protein_start="15"
                     /score="171.6"
                     /tool="antismash"
                     /translation="IVLGLMRIKSLSPREVEELVETALAAGINTFDLADIYGGGRSEEI
                     LGQVLKTRPDLRDQMWIQSKCGIRIEEFTYFDFSKEHILKSVDGILKRLHIQQLDSLLL
                     HRPDALMEPEEVAEAFNHLEKTGKVRNFGVSNQNPMMIELLKTAVSQPLAINQLQLSAA
                     FTPEFDTGFHVNMEEAIASSGPTGIFEYARAKDMVIQAWSVLQYGYFQGVFLGNPQFEK
                     LNQVLTRLAQNYQTTPSAIAIAWVLRYPAKMQAIIGTTQPQRILEAAQASTITLSRKEW
                     YEI"
     CDS             complement(12575..13006)
                     /locus_tag="ctg81_14"
                     /transl_table=11
                     /translation="LDYRLNLHESINDYLMKADLQDIAYVYRVKTSESILDKIDRFSEC
                     KEGYPVNSILNDIFGARVILQSEELTQVMEQLDAWKEGFGLKNWYLRDKDGYLGVYVYF
                     TNKSNFCYPWELQIWDAKDVDGNIQSHSLYKRNFVKHQS"
     PFAM_domain     complement(12596..12925)
                     /aSDomain="RelA_SpoT"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04607.19"
                     /description="Region found in RelA / SpoT proteins"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg81_14_0016"
                     /evalue="2.40E-05"
                     /label="ctg81_14"
                     /locus_tag="ctg81_14"
                     /protein_end="137"
                     /protein_start="27"
                     /score="24.7"
                     /tool="antismash"
                     /translation="RVKTSESILDKIDRFSECKEGYPVNSILNDIFGARVILQSEELTQ
                     VMEQLDAWKEGFGLKNWYLRDKDGYLGVYVYFTNKSNFCYPWELQIWDAKDVDGNIQSH
                     SLYKRN"
     CDS             complement(13131..14042)
                     /locus_tag="ctg81_15"
                     /transl_table=11
                     /translation="MYISVKRAADSWGISDRRVRDLCSQGKVEGAVREGRSWKIPQDTP
                     KPVDGRYKKAESLVVLIDQKMTKLASLRPLTQGEVERLNEEFMVEFTYNSNAIEGNTLT
                     LRETDLVLRGLTIDQKPLKDHLEAIGHKEAFEYVQTLVAAGTLLTEQVVKDIHYLVLSD
                     KKDDRGVYRKVPVRIVGAANEPAQPFMIRPLMEQLLKDYEDSQENMVTKMARFHILFES
                     IHPFIDGNGRTGRLLVNLELMKAGYPPIDIKFSDRLTYYRAFEDYHTKGSLSAMEDLFA
                     YYLNERLDMYLSILSFEDVDKD"
     PFAM_domain     complement(13320..13601)
                     /aSDomain="Fic"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02661.20"
                     /description="Fic/DOC family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg81_15_0017"
                     /evalue="1.70E-21"
                     /label="ctg81_15"
                     /locus_tag="ctg81_15"
                     /protein_end="241"
                     /protein_start="147"
                     /score="77.0"
                     /tool="antismash"
                     /translation="LTEQVVKDIHYLVLSDKKDDRGVYRKVPVRIVGAANEPAQPFMIR
                     PLMEQLLKDYEDSQENMVTKMARFHILFESIHPFIDGNGRTGRLLVNLE"
     CDS             complement(14255..14554)
                     /locus_tag="ctg81_16"
                     /transl_table=11
                     /translation="MTDKLIQDILKFRDDRGWGQAHSPRNLASSIIIEAAELLENYQWC
                     EEALDPINVQEEIADVLIYTLLLTDRLGLDVETIIQDKLKKNALKYPLPSEKLK"
     PFAM_domain     complement(14267..14464)
                     /aSDomain="MazG-like"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12643.9"
                     /description="MazG-like family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg81_16_0018"
                     /evalue="6.60E-15"
                     /label="ctg81_16"
                     /locus_tag="ctg81_16"
                     /protein_end="96"
                     /protein_start="30"
                     /score="55.2"
                     /tool="antismash"
                     /translation="IIIEAAELLENYQWCEEALDPINVQEEIADVLIYTLLLTDRLGLD
                     VETIIQDKLKKNALKYPLPSE"
     CDS             complement(14563..16101)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 92.9; E-value:
                     4.3e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg81_17"
                     /transl_table=11
                     /translation="MSILEVKRLSHGFGDRAIFEDVSFRLLKGEHIGLVGANGEGKSTF
                     MSIVTGQLQPDEGQISWSKYVKAGYLDQHAVLEAGMTVRDVLRTAFDDLFKTEARIQEI
                     YMEMAEATDYEALMEEVGELQDRLDSRDFYSLDAKIDEVARALGVSDFGMESDVTELSG
                     GQRTKVLLAKLLLEKPDILLLDEPTNYLDAEHIDWLKRYLLEYENAFILISHDIPFLND
                     VINLVYHVENQDLVRYSGNYEQFQEVYAMKKAQLEAAYERQQKEIADLKDFVNRNKARV
                     ATRNMAMSRQKKLDKMDLIELQAEKPKPQFDFKVARTPGRFIIQAQGLEIGYDRKLAGP
                     LDLTFERNQKIAIVGANGIGKTTLLKSLLGVIPALGGQVEEGEFLELGYFEQEVPGGNR
                     QTPLEAVWDAFPALNQAEVRAALARCGLTTKHIESQIQVLSGGEQAKVRLCLLMNRETN
                     VLVLDEPTNHLDVDAKEELKRALQAYKGSILMVCHEPDFYQGWVDQVWDFNELI"
     PFAM_domain     complement(14701..15081)
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg81_17_0021"
                     /evalue="1.00E-17"
                     /label="ctg81_17"
                     /locus_tag="ctg81_17"
                     /protein_end="467"
                     /protein_start="340"
                     /score="65.0"
                     /tool="antismash"
                     /translation="LDLTFERNQKIAIVGANGIGKTTLLKSLLGVIPALGGQVEEGEFL
                     ELGYFEQEVPGGNRQTPLEAVWDAFPALNQAEVRAALARCGLTTKHIESQIQVLSGGEQ
                     AKVRLCLLMNRETNVLVLDEPTN"
     PFAM_domain     complement(15163..15420)
                     /aSDomain="ABC_tran_Xtn"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12848.9"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg81_17_0020"
                     /evalue="1.50E-20"
                     /label="ctg81_17"
                     /locus_tag="ctg81_17"
                     /protein_end="313"
                     /protein_start="227"
                     /score="73.1"
                     /tool="antismash"
                     /translation="YHVENQDLVRYSGNYEQFQEVYAMKKAQLEAAYERQQKEIADLKD
                     FVNRNKARVATRNMAMSRQKKLDKMDLIELQAEKPKPQFDF"
     PFAM_domain     complement(15535..16044)
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg81_17_0019"
                     /evalue="1.70E-25"
                     /label="ctg81_17"
                     /locus_tag="ctg81_17"
                     /protein_end="189"
                     /protein_start="19"
                     /score="90.2"
                     /tool="antismash"
                     /translation="EDVSFRLLKGEHIGLVGANGEGKSTFMSIVTGQLQPDEGQISWSK
                     YVKAGYLDQHAVLEAGMTVRDVLRTAFDDLFKTEARIQEIYMEMAEATDYEALMEEVGE
                     LQDRLDSRDFYSLDAKIDEVARALGVSDFGMESDVTELSGGQRTKVLLAKLLLEKPDIL
                     LLDEPTN"
ORIGIN
        1 tgaaaacaat atgatcctgt ggtaagactg aagcaatttc tagtggtaag gtggtttgat
       61 ttgtgttata gtgaatgtac atgggatagc ctttctcagt attttatcct aattatattg
      121 tatcaagact atctccataa ggcaaaaaag caacggcttt aaaaccgttg ctttttgcgt
      181 tagtcagagg ggtttttgtc ccagcctcct taatccatag aattctagga agcagctgac
      241 ttattgcact tgagttgaca attcaagaaa tatttttaaa aagataaatt cctctaaaac
      301 actctttcta ccacctactg attcccaata aacaaatccc tttccatcaa aaaaagctgg
      361 gacaggccca gctaatgtta agagattcgt aataagcggc gcaaacggtt ggcctggctg
      421 cccatgaccc ggtccaaatg gttgcttttg agggccatcc aagcgtaaac gtagacggaa
      481 atagcaccca caatcattag gtgtaacagg ctgccccaac ggctgttgac tccaatcacc
      541 agggacaaga gggcttgggc cagcatggtc acgagcgaca taataagtgt cattaaagtt
      601 actagaacca cacgtttcat caggcgcttg tgattgaggc gtgtgacctg atgaatcgtg
      661 cggtacatca ggaagcaggg gaggactaag gctactccgg ttgacaggag tgggccatag
      721 gaaccaaaga tccagataaa tggaatttgc aagactagtt tggctcccaa gccgtaaagg
      781 aagtaaagca tggccaagcg attctggtag agggcttgaa tcattggcgc caaaacggtg
      841 tagaggccta ggaggagggt aaaggacatg gcccacacaa ataggtctag ggctgctcct
      901 tctggctggc cgtaaaagaa ggtatagagg gcccgcccca ttaataggga acctagcgtt
      961 gctggaatga ggaaggtcag cagcaaactg agattatcaa tgaccagttt ggctgctgcc
     1021 gccaagtcct ttttgacata gttctctgtc aagagtggga tccctactcc acccacagag
     1081 gaggcaaccg caatcaggat catgctgact ttattgggat tggctgagaa gtaggaaaaa
     1141 agcactagaa gctctgtttc tgaggtcttg gtaaaccagc gggagacatt aataaaagtc
     1201 atttggtcaa taatttgaaa gagctggatg gcagaccctg tgataataaa aggtatggct
     1261 tctttgagcg tttctagcac cagttggctg ccaccttcca gtttttgacc agaagcagca
     1321 aggatggggc gtaaaagccc ttcttgatta agcaaaaaaa tcaaaagcgc catcgaggcc
     1381 agcatcccaa taaaggcggc aagggtggat tgggtaacgg ccgagacgta gtccttattg
     1441 cccagctgca taatcaggaa ggtcgccagc aacatccaga tgacccgggc cacctgctct
     1501 gcaatctggc tcatggcata ggggcgcata ttactgtaac cttggaaaac accgcggata
     1561 atactcatag ctggaaaaat cagcacggcc caggccaaac tctgcatgac cggggtcaac
     1621 tcagcaccaa ctcccgaacc cgaagcgaag aggggagcgg ctagatacat gagggcggca
     1681 aaaaccagac caaggatcac catcaatttc aaaaaacggt tgatcagggc aaaggacttg
     1741 tcctcctgcc ccatggtatt gtatttggca atctgtttgg aaatcgctac tggcaggcct
     1801 gcggttgaga ccaaaaggaa ccaggcgtag atattataac ccatggtaaa aagtccattg
     1861 gcctcggctg catgagcccc catccagcca taccacggaa taatatagag ggccccgagc
     1921 aggcggctaa tgaggttact agcggtcatc caagccgctc ccttcagcat cagctcctgc
     1981 tgacgcgctt gttggtcatt cattctaatc cccttttaat actacttcca aattaaaata
     2041 agctctcaaa ctcgttctca tcataggacc taaacttaca atgtatgaag aaaactcgaa
     2101 agagtctaat acctaattaa aatcaaaatt tgaatactcg aataatttca aggaattgac
     2161 taggaaagcc gacgaaggta gaacttaggt tcatcaagga ggcttgacaa catcaaaatt
     2221 tgaaattaaa tgagtctaag ctattcgaaa atactagtac cattatagca tgaaggccca
     2281 gtccctccaa gattttaacg aaaaaaaggc aatcatcttt gacttgtaaa agcacaccag
     2341 aagggttaca atagggctat gatgaaactt gaaaccgcct tacaaatttt acaagcggac
     2401 cataacttcc gtgctattgt cgaccaggat accttccact atcgaggcca cgattggacc
     2461 ttccaagagc tgagctatga tagtcgccag gtctctgaac acaccctctt ttttgccaag
     2521 gggcaacagt ttaaagccga ataccttgaa gctgccatcc agcaaggctt gcgctactat
     2581 gtcagtgaga ttgactacca agtcgccatt cctgtgattt tggtcaatga tatcaaacag
     2641 gccatgagcc tgattgcgat ggaattttac caacaccccg agaaaaagct caagctctta
     2701 gcttttactg ggaccaaggg gaaaacaacg gctgcttatt ttgctttcaa cattctcaag
     2761 caagaatgga aacccgccat gctttcaacc atgaactcaa cgctggacgg ggtccatttt
     2821 ttcaaatcgc aactaactac tcctgagagt ctggatctct ttgccatgat ggccgaagct
     2881 gtcgcccatg gccgtaccca ctttattatg gaggtgtcca gtcaggccta cttggtcaag
     2941 cgggtctatg gcctgacttt tgatgtcggc gtctttctca atatcagccc cgatcatatt
     3001 gggccgattg aacatcctag ctatgaggac tacttctacc acaagcggca gctcctagcc
     3061 aacagccgct tcctcatttt gaaccagcaa atggatcata gcgactttct cttggattcg
     3121 attcaagacc aaccgcacac aacctatggc ctgggaagtc ccaataccat tgaagaatct
     3181 gcggcctttc acttcaaggt tggtggtcct ctcgctggcg attatgatat tcaattaatt
     3241 ggtgacttta atcaagaaaa tgccctagcc gctggcttgg cctgccaaca gctagaagca
     3301 agtccagcag ccattcaagc cggtatcgcc caaaccaagg ttgatggtcg gatggaagtt
     3361 ttaacccatc cttctggagc taaaattttt attgactatg cccacaatgg tgatagtctg
     3421 aaaaagctaa tcgataccgt ggcccactac cagaagggca agctcgccct catcctcggt
     3481 gccactggca acaagggaga aaaccgccgc aaggactttg gccttctctt aaacgactac
     3541 ccagaccttg aggtcgtcct caccgcagac gatcccaact atgaggatcc cgtggccatt
     3601 tcccaggaaa tcgccagcta cctccaccgc cctgtaacca tcattgccga ccgcgaaaca
     3661 gccatccaag aaattctgag ccaacagtat cagagtgagg atgccattat cattgctggt
     3721 aaaggagcgg atgcctttca aattgtccaa ggggaaaaaa tcccctatcc cggcgacccc
     3781 caagttgtcg tccaagcact tgaataatcg taaaaaggaa ccaattgtgg ttccttttta
     3841 cgatggctaa tttttagtag ctttaatctt ttgcgctgcc cgaacccgat tttcatagga
     3901 ctgggctaaa tgaatacttc ccagggcgcg gaaggactca atcacagctt ccatctgcat
     3961 caatccttta cgttcatcat gaaagaagaa ctcaaacatt ccttctccat attgaaccac
     4021 catccgttca aacatatccc gctcttcaaa gtgatgattt ttgatgaatt ttcggtagta
     4081 ctgggcgtca atgagttcct gacgttcgca ggatagcaca aaggcttcca agaccaaata
     4141 attaatcatc cggcgattga gaggaagctc cttataaaac tccgaccgtg agatcatttc
     4201 cttggacagg gtcataaaca gcgcatggcg aaaacggtgc atggaatggg taaatagcag
     4261 taattcatag tagccccaat actcaacgcc aattaggtaa tccgtcaaga cacttaaatc
     4321 acgctcagac acaaccggat ctccggtcat ttcttccagt ttgattttaa tgataatcgt
     4381 gtttaattca taaaacaagc gtcttagccg gggtttgaca ggtctagatt ccaagaggtg
     4441 gcgcatgctg acaacatcat tttgaagcac ataaatatcc atctggtgca gtaattcctg
     4501 caactcatca cgtttaaagt cttgaaccgc atagagaaat tcagacatgg gcatattgat
     4561 ttcatctaaa gcaattttaa acttcgagat ggtgagatcg gactggccat tttcgaaccg
     4621 cgataattgc gacacggata aatcttttgt ggcaatggag cgcaaggaca agcctcgtga
     4681 ctgccgaaat tgtttaaaca cttttccaaa tgatttcata tagacccttt acattgttta
     4741 taagcgaaag aaggcagatc caaccaagac ctaccttcct cacattttaa ttggcaaaag
     4801 ctgctgttag ttgtggaaca acttgttttt tacgagatac agcaccaggc aagaaggcat
     4861 ggtgattttc caaagtgaaa ccgaaggctg cttcaacctt gtctggattt gcccccaagg
     4921 tcaaaatctc agagttcgag ttgacaatat cggtaatcat caagacaaaa tcagagtagc
     4981 ctgcttctgc catagctgct tgcatagctt cttcaatttc agcttggcgt tccaaaattt
     5041 cagcgatatc aaccgtattg acttgggcta cacggacagt gttcccaccc aattcaaagc
     5101 tcttagcatc aatatcgatc aattcagcag ctgttttgct ggagagattg gtcccagctt
     5161 tcaacatttc tagtccataa gcctccaagt ctacaccggc tagctctgct aactcagctg
     5221 ccaaaggaac atctgtgaca tgggttgttg gtgattttaa caaaagtgtg tctgaaatca
     5281 aaccagacag catcaaacca gccaattctt ttggtacttg gacttggttt tctttaaaca
     5341 tccggtaaac aatcgaagat gctgaaccaa ctggctcaag acgcataaac aagggattag
     5401 cagtctcaaa gttagcgaca cggtggtggt caacaacacc gaaaacttca acatcacgga
     5461 tgccttctgc agattgttgg aactcattat ggtctgtcaa gataacttgt tcaacacctt
     5521 cctgggcaag ggattgaatt tcacgtggcg tctcaacacc aaaatagtct aacacaaagc
     5581 gcgtttcttc attaggttgt cccaagataa ccgcttctgt atccaaacca tgagcttggc
     5641 gagctaaata agcataggca taggatgatg caatcgcatc tgtatcaggg ttttgatgac
     5701 caaaaaccaa gatttttgac atgtttctac ctcttttcca attttcattt actattttaa
     5761 cacaaagaag ggacttctac caagtggcaa tcttcagaat tagccctttt ggacccgctt
     5821 gagatagtct tggtaggatt ctgtctccat taacttcttg gcattggcaa cccgctcttt
     5881 ggttggtggt ttcacccctt tgagtggata gtcaattccc aatttttccc atttaaattc
     5941 acccatggtg tgataaggca ggatctcaaa tttatcaaca tttttcaagg tttttacaaa
     6001 ttcacctaac tccttcaagt cctcatcatg gtcggtcaag ccgggtacca aaacgtggcg
     6061 aatccagact ggaatccctt tatctgacag gtagcgggca caatccagaa tattgcggtt
     6121 gctttggctg gttacaaatt tgtgtcgctc gtcattgatc tccttgatat ccagcaagac
     6181 caaatcggtc acagccatca atcggtcaaa tacttccaaa tactccggct tgttgcgaaa
     6241 aggcagggca caagtatcca aagttgtatg gatgcccaat tctttagctt tggtaaaaag
     6301 ggcaatcaga aagtcgattt gcaagagggc ttctccaccg ctaacggtaa tccccccatt
     6361 cttgccccag taacccctat aacggagggc ttctttcaga atatcatcca ccgtccgcgt
     6421 ctgtgcctgt tcattttcaa aggcccaagt atctggattg tgacagtact ggcagcgcat
     6481 cttacatccc tgcaaaaaca caataaagcg gatgcccgga ccatcaacag ccccaaaact
     6541 ctctgtcgaa tgcacgtatc ctgttacctg tccataatca attacttgtc ccataacagc
     6601 cctcctgtaa gcgttttact ttctttagta tagcactttt tttgacaatg ggaaagtttt
     6661 tccaaaccat ttccaagtaa gactatttat ccctatcaga actggaaaag acagctacta
     6721 aaaaagaggc cagggatctt gtcccagcct ccttggctta aaccttattt agaagtcgtt
     6781 tcttccaggt cttcttggat tttgtctatg tggaggcgaa gtttggttac tcgacctcgt
     6841 ttcaccttgt cattacgcag ggtgaggcga tagccattgg actccaaatc aaccgagagg
     6901 cgttcccctt ctgttgggat gctgcctaga gtggtgatgt agtaaccagc aatggtatcg
     6961 acatcatcac ttgccagttc cacatcaaag tgttcattaa aatcattgag ggtcatggct
     7021 ccgaggacaa tgtagcttcc atctgctaat tcacgaactt caagctctgc cttatcggtc
     7081 tcatcctcaa tctctccgac aatctcttct aagagatctt ccagggtcac cagacctgca
     7141 acacctccat attcatccag caaaatcgcc atctgattct gggtattccg caaggaagcc
     7201 aagagatcat cgacaaacat ggtttctggt acaaagaggg gctcttggag aattttctcc
     7261 aaggatagat tttcaaaacc agccgtaaag gcttcggtca aaatccgctt ggtatgaaga
     7321 ataccgatga tgttatcctt gtcaccctcg tagacgggaa tccgtgaaaa gttttgcttc
     7381 aaaatcgctt ggatattctc ttcgcttgcg ttcttgatat ccaccataaa ggcatcagtc
     7441 cggggcacca tcaattcacg cgccatcagt tcatccaagg tgaaaacccc ttgaagcatc
     7501 tccaattctt ccgcatccag gctctcctca ctttttgaga gcatgtattc gatctcatcc
     7561 cgcgtcattt tttcatcggc atcatcaaac tccattggcg tcaaacgact gagaaggttg
     7621 gtggaagccg atagcaacca aacgaaggga ctgacaattt ttcccaaaaa taaaataatt
     7681 ggagctgtgc ggacagctag ggattccttg aggttcaagg caattcgctt aggataaagc
     7741 tcacccagca caatcgaaat gtaggtcaac agtgccaaag caagtaagct tccgaccgca
     7801 taggccgtct caccgccccc catccaggtc gcaaacatac ggcccagggt atcggccaag
     7861 ctagccccgg ccaagatatt gatcagggta atcccgactt gaatcgtgga tagaaaatga
     7921 ttgggctcct ccaagacatt caacaaacgc tgataagccc ggtctccctc tccagccttc
     7981 tgctccacac gcgaacggtt gagcgacacc atagccatct cagaagctga aaagaaggca
     8041 tttagaaagg tcaggaaaaa gagtaataca atctgtacca ccaaattctg actgctagga
     8101 tcttccattg tgttttttct cctaataatg taaagataag cttattttac catattttac
     8161 aaaaaacaag aaagtgggac agaaggaaac taaaaaattc ctcctacccc actcttgttt
     8221 ttcctaatcg agtggctgcc ctgccgcaat tcgatcaatc agttccaggt cctcccagac
     8281 tgaatcaatt tccgccttgg tcgggtacgt ctctaatacc cggtccaaac gctggcgaat
     8341 ccgagccgct tctacctggt cttgcttgga cagccgggcc agagcatagt tcagactcaa
     8401 aacaaaagga tagtccttca ttcccttaag gaactgctgc gtttccttgt catctaatac
     8461 agacaaatcc acactacctg cctccgttaa caaatcgtaa tagagcttga acagttgcat
     8521 cgtggtccgc tcgaagctag gtactgaaga cttgctttcc aataaacttt gaagcaagtc
     8581 tatccccgct tgttcctccc ctttatcaat catatattga gctcgtgtaa atgccaaact
     8641 cgcagccgag gagttttcag atcgactctc agactcgatc cggaaccaat ccgctggtaa
     8701 ggctcgcaac tgttggcctc tagtcatggc ttcgaggatc aacatctgtt tggcaaaaac
     8761 ttcgcgctca gcgggatttt tagacaagtt ccaagcattc cagccgtcat ttgcaacgac
     8821 cttccctttc caagggatcc catttgccaa agctgacaat aaattgagcc cgccaaatga
     8881 ccatagcaac agggtccaca cagacggttg catctccaag gctaaaaaga atacgagact
     8941 cagcagcaga ttcatcagcg gaccacctag gtggtagcgt aaaaacggaa actggtcatc
     9001 gctcctcacc ggtggtacca tgatacattg accacctgta cccattaagg aaaatcgttt
     9061 ccagaccaag ccctcatccc agcgaactag gacacggttt ccgacccgaa aagagacgaa
     9121 atggtaacca gaccacagcc ccccgagcag atgaccaaat tcatgtagca aaactactag
     9181 cagatagagc ggcagatgaa gtaaaatcag gaaggtactt tcaaaaagag tttctagcca
     9241 aacattattc cagctaggtc caacataaac ctgcgcaagc aaggctccaa atcggagtcc
     9301 ccaccaaaaa gcagcaccta gcaaaaccaa agtataaacg accttcagca aaccattctt
     9361 cataagtgac tccccttcta gcctaacctt ttttagggtg acgatctaaa acctctgtat
     9421 gttggtcaaa aagggcctgt ccttgagctg tcaaacaata gccccgaatg tcaaaactag
     9481 cttccagagc ctggtcttca acctgatcca acagggcctg gtctagttct gccgccttca
     9541 tcttagaaaa acctttaacc ccttggttct tgaggatagc cttcttctga ccggcattaa
     9601 tatgggccag cgattcacgc gctttttgct ggcggaccaa accgcgctcc tcaagcactt
     9661 gtaaattgtg gggggcatca atcccgtagg tatattcaaa gtacttagga aaaaccgatt
     9721 ctgttgtaaa agtccccagg gcaattcgcc acaagagaat cacatcacca gcaagaatct
     9781 ccccttctaa gagctccata ttttttcgcg gaacagccgg tgcaacctta ccttgggcat
     9841 gatccagtgc ctgctgctcg gaaataaagg gctggactgg ataatccgca taacgttctg
     9901 ccaaactaac catcttaccc ctctacttct gcagaaattt gccagttgat cccataccta
     9961 tcaatcaagt tggcataggc tggtgaccag aaggtttctt gcaattccaa ggtcacctcc
    10021 tgcgcctctt cttttagggc atcgtagagt ttttgagcag ctactactga atctacgatg
    10081 attgatggta ccacattacg accaggagca tagctatact ctggactttc atctgagatt
    10141 tgcagacgaa tcccgtcaac caccagttgc gcattcaaga ccaagtgctt atgctcatca
    10201 gctacgtcag gaatcgcatc gccccagagg gtcaagctcg tcacttcagc acctaacaca
    10261 cccttgtaaa attcaacagc ctcttgacca ttgccatccg tcaccaaata cacttccatt
    10321 cttttaatca ttttttcacc tcacgaattg caaaatagtt ttcttctaaa tcggaaaaat
    10381 taaagacccg catgagatct aagtcaacaa taggcataac taaaatgccc cgatcgagca
    10441 tgaatgggta ggttgcatcc aagtcagaat actccattaa aaaggacggt cttcccaaat
    10501 ccaattcagg gttcaattca gctaccttga cctggtcttg aaacacagac tttagctgac
    10561 catccttctt aagaatccac aagtcggaaa cgattcccct actctcctga cactcaacca
    10621 actggggctt tccagagccg ttatataggc cattatttga ctgaaagagt cactcatcct
    10681 gtactcctcc gtctatccct agtataccac ggatctccgt aaaaagcttg aaagtccctc
    10741 ctccattcgt tataatgagc acagaacacg aaaggaaatc aactatgaaa aaactactca
    10801 ttgcaggcct actggccagt gcagcgaccc tagccctcat catctatcaa aaccaaccca
    10861 aacaagaatt aagtttaaac gcccagctcc aagaagtcct caaaaatcca gagaccgact
    10921 ttccccagtt gacgaccaag gctagtaaac aggagccgat cgtgaccctc aaaaccagcc
    10981 aaggcgacat cagcctcaaa ctctttccgg aatacgcgcc cttggccgtt gagaacttct
    11041 tgacccatgc caaggaaggc tattatgatg gcctcagctt ccaccgggtc atcaaggatt
    11101 ttatgatcca aaccggagac cccaagggtg acgggagcgg aggtgaatcc atctgggctg
    11161 gtaaagacaa cgaaaaagat ccgggcaccg gctttaagaa cgaaatcagc ccctacctct
    11221 acaatatccg aggcgctgtc tccatggcca atgccggccc cgacaccaat ggcagccaat
    11281 tcttcatcaa ccaaaacacc caagatatct ccagccgctt ggatcccaac acctaccatc
    11341 ccaaaatcat ccaagcctat caaaaaggag gcaaccctag cctcgacggc tcttacaccg
    11401 tcttcggaca ggtcacccaa ggcatggagg ttgtcgacaa aatcgctgcc acggaaacag
    11461 acgacaaaga taaacccaag gaagccatca ccatccaaaa aatcaccatt caatccgaat
    11521 gagcccctca acctcagaca caatccgcct gaggtttttt aaaactactt tatctcgaaa
    11581 ggatcaccca catgaaaacg attgaactca actcagaaaa caccaaacta tccagtatcg
    11641 tcctaggcct gatgcggatc aaaagcctct ctcctcgaga ggttgaggaa ttagtcgaaa
    11701 ccgccttagc agcaggcatc aacacctttg accttgcaga catctacgga ggcggacgct
    11761 ccgaagagat actcggacaa gtcctcaaaa ctagacccga cctgcgcgat cagatgtgga
    11821 tccaatccaa atgcggcatc cgcatcgagg aatttaccta ctttgatttc tccaaggagc
    11881 atattctcaa gtccgtcgac ggcatcctca aacgcctcca catccagcaa ctcgatagcc
    11941 tgcttcttca tagaccagac gctctgatgg agccagaaga agtcgccgaa gccttcaacc
    12001 acttagaaaa aacaggcaaa gtccgtaact ttggagtctc caatcaaaat cccatgatga
    12061 ttgaactcct caaaacagcg gtttcccaac cactcgccat caaccaactc caactcagtg
    12121 ctgccttcac accagaattt gacacaggtt ttcatgtgaa catggaagaa gccatcgcca
    12181 gctctggtcc aaccggtatc tttgaatacg cccgtgcaaa agacatggtc atccaagcct
    12241 ggtcagttct ccaatacggc tatttccaag gagtcttctt gggaaacccc caatttgaaa
    12301 aactcaacca ggtcctcacc cgcctagcgc aaaactacca gaccactcct tcagccattg
    12361 ccatcgcctg ggtcctgcgc taccctgcta agatgcaagc catcattggc accacccaac
    12421 cccaacgcat tttagaagct gcccaagcta gcaccattac cctcagccgc aaagagtggt
    12481 atgaaattta cctggccgct gggaaatcac ttccttaagt ttgaaagcgc aaaaagacca
    12541 gtcttcttag caaaagaggc tggccttttt tgtactagga ctgatgcttg acgaaattcc
    12601 gtttataaag gctatgactc tgaatattac catccacatc tttggcatcc cagatttgga
    12661 gctcccaagg atagcaaaaa ttacttttgt ttgtaaagta aacatagaca ccaagatagc
    12721 cgtccttatc gcggagatac caatttttta aaccaaatcc ttccttccaa gcatccaact
    12781 gctccatcac ttgcgtcagt tcttctgact gtaaaatcac ccgtgctcca aaaatatcat
    12841 ttaaaatgga attgacaggg tatccttcct tacattcaga aaaacggtcg attttatcaa
    12901 gaatactttc agatgttttc acacgataaa cgtaagcaat atcctgaaga tcagccttca
    12961 tcagataatc attgatcgac tcgtgtaaat ttagccgata gtccaaaata gcctgcgtcg
    13021 gaaccttagc aagcgttcaa ctttagtaag caaagggaat acctcccact ggtgacaagt
    13081 cttagttttc agctcacaag ctttctacga cggcttgttt atgcttcata ctaatctttg
    13141 tctacatcct caaaagaaag gattgacaaa tacatatcca atctctcatt taaatagtaa
    13201 gcaaacaagt cctccatcgc tgataaactt cctttggtat gatagtcctc gaaagctcgg
    13261 tagtaggtca agcgatctga aaatttaata tcaatgggag ggtaacccgc cttcatcaac
    13321 tctaaattca ccaaaaggcg ccctgtacgc ccattaccat caataaaagg atggatactt
    13381 tcaaaaagaa tatgaaaacg agccatttta gtcaccatgt tctcctgact atcttcatag
    13441 tctttcaaca attgctccat caaggggcga atcataaagg gttgagcagg ttcgttggca
    13501 gcccctacga tacgaacagg taccttgcga taaacacctc gatcatcctt tttatccgat
    13561 agaaccaaat aatgaatatc ttttacaacc tgttccgtca agagagttcc tgctgccacc
    13621 aaggtttgca catattcaaa agcctccttg tgtccaattg cttcgagatg atcctttaga
    13681 ggtttctgat caatggtcaa gccacgtagg accaaatccg tctcacgaag cgtcagagtg
    13741 ttcccctcaa tcgcattgga gttataggta aactccacca taaactcctc atttaggcgc
    13801 tcaacctctc cttgggttaa gggacgaagg gaggcaagtt tagtcatctt ttggtcaatt
    13861 aaaaccacca gactctccgc ctttttatag cgaccatcaa ccggtttagg cgtatcttgc
    13921 ggaatcttcc acgaacgtcc ttcacgaaca gcgccctcca ccttcccctg gctacacaaa
    13981 tcacgcacac gacgatcaga aattccccaa gaatcagctg ccctcttaac ggagatatac
    14041 ataaaacacc tcaccttcta aaaaattatt catttcctaa aaccattata gcagagttcg
    14101 gaaggatagg gttcttaacg gaaggatagt tagggtattt tcggaaggat aatgacccta
    14161 gtcgtccctt accccgatag ttttattcct gcaaaaagac ttaaaaactc aatcaggctc
    14221 ctatcttcag agctttcgat tgggttttca gtctttattt caacttctct gacggtagcg
    14281 ggtatttcaa ggcatttttc ttgagtttgt cttggatgat ggtttccaca tccaaaccca
    14341 ggcggtcagt gaggagtaag gtgtagatga ggacatcggc gatttcttct tggacattga
    14401 tggggtccaa ggcttcctcg caccattggt agttttctag gagctcggcg gcttcgatga
    14461 tgatcgagct ggccaggtta cgggggctgt gggcttggcc ccagccacgg tcatcgcgga
    14521 atttcaggat atcttggata agtttgtctg tcatagaggc tcctaaatca attcattgaa
    14581 gtcccacact tgatcgaccc agccctggta gaagtctggt tcgtggcaga ccataaggat
    14641 gctgcccttg taggcttgga gggctcgttt gagttcctct ttggcatcca catccaagtg
    14701 gttggtaggc tcgtccagga cgaggacatt ggtttcgcgg ttcatgagca ggcagaggcg
    14761 gaccttggcc tgctcacctc cactcagcac ttgaatttga ctttcaatgt gcttggttgt
    14821 caggccacag cgggctaggg ctgcgcggac ctcggcctgg ttgagggctg gaaaggcatc
    14881 ccagacagct tccagaggtg tttggcggtt gcctccaggt acttcttgtt caaagtagcc
    14941 cagttctagg aactctcctt cttcaacctg acctcccaaa gcaggaatga cacctagaag
    15001 acttttgagg agggttgttt tcccgattcc gttggcccca acaatggcaa ttttctggtt
    15061 gcgttcaaag gtcagatcca gcggtccggc cagtttgcgg tcatagccaa tttccagacc
    15121 ttgggcttgg ataataaaac gtcccggtgt ccgtgccacc ttgaagtcaa actggggttt
    15181 aggcttctcc gcttggagtt caattaggtc catcttatct agcttcttct gccggctcat
    15241 ggccatgttg cgagtcgcta cccgggcctt gttgcggttg acaaagtctt tgaggtcggc
    15301 aatctccttc tgctggcgtt cataggctgc ttccaattga gccttcttca tggcatagac
    15361 ttcctggaac tgctcataat tcccgctgta gcgcactaaa tcttgatttt caacatgata
    15421 aaccaaatta atcacgtcat taaggaaggg aatatcatgg gaaattaaaa taaaggcatt
    15481 ttcatactct aagagataac gtttgagcca atcgatgtgc tcagcgtcca ggtagttggt
    15541 aggttcatcc aagaggagta tgtctggctt ctccagcagc agcttggcca agagcacctt
    15601 ggtccgctgg cccccactaa gctcagttac atccgactcc atcccaaaat cgctgacccc
    15661 aagggcacgc gccacttcat caatcttggc atcaaggcta tagaaatcgc ggctatccaa
    15721 acgatcctgc aactcgccaa cctcttccat caaggcctca tagtccgtag cctccgccat
    15781 ctccatgtag atttcttgaa tccgcgcctc ggttttaaac aaatcatcga aggcggttcg
    15841 cagcacatca cgcacggtca taccagcctc caaaactgcg tgctggtcca gatagcccgc
    15901 cttgacatac ttggaccagc ttatttggcc ctcatccggc tgcaactgcc ccgtcacaat
    15961 gctcataaag gtggacttgc cttcaccatt ggcacccacc aagccaatat gttccccctt
    16021 taacagacga aaggaaacat cctcaaaaat ggcccgatct ccgaaaccat gactcaaacg
    16081 cttaacttct aatatactca tacttttcct attcttcaaa aaagagggga gtgggacaga
    16141 actaaatttg aaaaaattta gtttattcgc tttcttaatt tcaggctcat gctaaaaaga
    16201 tccactggag ctttttactc ccacccccgc aaggctgatt aggccctctt tcgagcttga
    16261 aaagcgaacg attgaagttt gcttcgcaaa caagatttgg tactctctaa cagcatacaa
    16321 tgctgttaga cccaatcagc tactgcgtca aaggtatttt gttatacaaa gtcaatgagg
    16381 ctagactttt gccccagcct catctctttt atcaatttat agtcttttat acgacttcag
    16441 ctaccctaga gacttcctaa actaatttct gcaaaaaggc gataaggacc tgggctgatt
    16501 tccggccagc ttccacgata aattcatcaa aggaaagagc cgcatcctgc tcagcagtat
    16561 cactcatagc ccgtaccacc ataacgggca ggtt
//
