Select genomic region:
Overview
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1.10

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP051464.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1 | NRPS | 355,805 | 418,406 | surfactin | NRP:Lipopeptide | 78%
Region 2 | terpene | 1,153,642 | 1,174,167 |
Region 3 | NRPS,betalactone | 1,869,929 | 1,947,473 | fengycin | NRP | 100%
Region 4 | terpene | 2,025,801 | 2,047,699 |
Region 5 | T3PKS | 2,094,862 | 2,135,959 |
Region 6 | NRPS | 3,046,989 | 3,094,128 | bacillibactin | NRP | 100%
Region 7 | lanthipeptide-class-i | 3,241,140 | 3,267,365 | subtilin | RiPP:Lanthipeptide | 100%
Region 8 | CDPS | 3,376,685 | 3,397,431 |
Region 9 | sactipeptide | 3,640,722 | 3,662,334 | subtilosin A | RiPP:Thiopeptide | 100%
Region 10 | other | 3,665,123 | 3,706,541 | bacilysin | Other | 100%

NZ_CP051464.1 - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 355,805 - 418,406 nt. (total: 62,602 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000389.1 |  | 0.42 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0000426.1 |  | 0.42 | NRP | sevadicin | Paenibacillus larvae
BGC0001050.1 |  | 0.37 | NRP, Polyketide | thalassospiramide A | Tistrella bauzanensis
BGC0000433.1 |  | 0.37 | NRP | surfactin | Bacillus velezensis FZB42
BGC0001833.1 |  | 0.33 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001767.1 |  | 0.33 | NRP | salinichelins | Salinispora pacifica CNY331
BGC0001615.1 |  | 0.33 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0000417.1 |  | 0.32 | NRP | rhodochelin | Rhodococcus jostii RHA1
BGC0000410.1 |  | 0.32 | NRP | pseudomonine | Pseudomonas fluorescens
BGC0001890.1 |  | 0.32 | NRP | amphi-enterobactin 1, amphi-enterobactin 2, amphi-enterobactin 3, amphi-enterobactin 4 | Vibrio campbellii ATCC BAA-1116

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000389.1 |  | 0.74 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0000426.1 |  | 0.73 | NRP | sevadicin | Paenibacillus larvae
BGC0001050.1 |  | 0.70 | NRP, Polyketide | thalassospiramide A | Tistrella bauzanensis
BGC0000433.1 |  | 0.69 | NRP | surfactin | Bacillus velezensis FZB42
BGC0001833.1 |  | 0.66 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001767.1 |  | 0.66 | NRP | salinichelins | Salinispora pacifica CNY331
BGC0001615.1 |  | 0.66 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0000417.1 |  | 0.66 | NRP | rhodochelin | Rhodococcus jostii RHA1
BGC0000410.1 |  | 0.66 | NRP | pseudomonine | Pseudomonas fluorescens
BGC0001890.1 |  | 0.66 | NRP | amphi-enterobactin 1, amphi-enterobactin 2, amphi-enterobactin 3, amphi-enterobactin 4 | Vibrio campbellii ATCC BAA-1116

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 355804 - 418406:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (glu - leu - D-leu) + (val - asp - D-leu) + (leu)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_356: glu - leu - leu
  Search NORINE for peptide: strict or relaxed
  AMP-binding (466..867): glu
  NRPSPredictor2: glu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      glu, gln
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAKDLGVVDK
    Nearest Stachelhaus code:
      glu
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1510..1908): leu
  NRPSPredictor2: leu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      leu
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAFMMGMVFK
    Nearest Stachelhaus code:
      leu
    Stachelhaus code match:
      100% (strong)
  AMP-binding (2550..2938): leu
  NRPSPredictor2: leu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      leu
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAWFLGNVVK
    Nearest Stachelhaus code:
      leu
    Stachelhaus code match:
      100% (strong)
ctg1_357: val - asp - leu
  Search NORINE for peptide: strict or relaxed
  AMP-binding (470..864): val
  NRPSPredictor2: val
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      val
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAFWIGGTFK
    Nearest Stachelhaus code:
      val
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1502..1905): asp
  NRPSPredictor2: asp
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      asp, asn
    Single AA prediction:
      asp
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLTKVGHIGK
    Nearest Stachelhaus code:
      asp
    Stachelhaus code match:
      100% (strong)
  AMP-binding (2547..2935): leu
  NRPSPredictor2: leu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      leu
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAWFLGNVVK
    Nearest Stachelhaus code:
      leu
    Stachelhaus code match:
      100% (strong)
ctg1_358: leu
  Search NORINE for peptide: strict or relaxed
  AMP-binding (469..867): leu
  NRPSPredictor2: leu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      leu
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAFFLGCVFK
    Nearest Stachelhaus code:
      leu
    Stachelhaus code match:
      100% (strong)

NZ_CP051464.1 - Region 2 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,153,642 - 1,174,167 nt. (total: 20,526 nt) Show pHMM detection rules used
terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000885.1 |  | 0.29 | Other | 4-hydroxy-3-nitrosobenzamide | Streptomyces murayamaensis
BGC0000846.1 |  | 0.27 | Other | tabtoxin | Pseudomonas syringae
BGC0001735.1 |  | 0.27 | Other | pentostatine, vidarabine | Streptomyces antibioticus
BGC0000645.1 |  | 0.25 | Terpene | carotenoid | Halobacillus halophilus DSM 2266
BGC0000937.1 |  | 0.23 | Other | fosfazinomycin A | Streptomyces sp. WM6372
BGC0001739.1 |  | 0.20 | Other | phosphonoacetic Acid | Streptomyces sp. NRRL F-525
BGC0000928.1 |  | 0.19 | Other | T3 toxin | Cylindrospermopsis raciborskii T3
BGC0000188.1 |  | 0.19 | Alkaloid | saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2 | Cylindrospermopsis raciborskii T3
BGC0000887.1 |  | 0.17 | Alkaloid | saxitoxin, gonyautoxin 2, gonyautoxin 3, toxin C2, toxin C3, gonyautoxin 5, decarbamoylsaxitoxin, decarbamoylgonyautoxin 2, decarbamoylgonyautoxin 3 | Dolichospermum circinale AWQC131C
BGC0001374.1 |  | 0.17 | Other | thienodolin | Streptomyces albogriseolus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000885.1 |  | 0.63 | Other | 4-hydroxy-3-nitrosobenzamide | Streptomyces murayamaensis
BGC0000846.1 |  | 0.61 | Other | tabtoxin | Pseudomonas syringae
BGC0001735.1 |  | 0.60 | Other | pentostatine, vidarabine | Streptomyces antibioticus
BGC0000645.1 |  | 0.58 | Terpene | carotenoid | Halobacillus halophilus DSM 2266
BGC0000937.1 |  | 0.56 | Other | fosfazinomycin A | Streptomyces sp. WM6372
BGC0001739.1 |  | 0.52 | Other | phosphonoacetic Acid | Streptomyces sp. NRRL F-525
BGC0000928.1 |  | 0.51 | Other | T3 toxin | Cylindrospermopsis raciborskii T3
BGC0000188.1 |  | 0.51 | Alkaloid | saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2 | Cylindrospermopsis raciborskii T3
BGC0000887.1 |  | 0.48 | Alkaloid | saxitoxin, gonyautoxin 2, gonyautoxin 3, toxin C2, toxin C3, gonyautoxin 5, decarbamoylsaxitoxin, decarbamoylgonyautoxin 2, decarbamoylgonyautoxin 3 | Dolichospermum circinale AWQC131C
BGC0001374.1 |  | 0.48 | Other | thienodolin | Streptomyces albogriseolus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP051464.1 - Region 3 - NRPS,betalactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,869,929 - 1,947,473 nt. (total: 77,545 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | betalactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000407.1 |  |  | 0.81 | NRP | plipastatin | Bacillus subtilis subsp. subtilis
BGC0001095.1 |  |  | 0.76 | NRP | fengycin | Bacillus velezensis FZB42
BGC0001615.1 |  |  | 0.65 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0001103.1 |  |  | 0.62 | NRP, Polyketide | mycosubtilin | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0001833.1 |  |  | 0.58 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0000426.1 |  |  | 0.57 | NRP | sevadicin | Paenibacillus larvae
BGC0001844.1 |  |  | 0.57 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001890.1 |  |  | 0.56 | NRP | amphi-enterobactin 1, amphi-enterobactin 2, amphi-enterobactin 3, amphi-enterobactin 4 | Vibrio campbellii ATCC BAA-1116
BGC0001758.1 |  |  | 0.55 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001132.1 |  |  | 0.55 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000407.1 |  | 0.85 | NRP | plipastatin | Bacillus subtilis subsp. subtilis
BGC0001095.1 |  | 0.82 | NRP | fengycin | Bacillus velezensis FZB42
BGC0001103.1 |  | 0.71 | NRP, Polyketide | mycosubtilin | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0001833.1 |  | 0.68 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0000426.1 |  | 0.68 | NRP | sevadicin | Paenibacillus larvae
BGC0000389.1 |  | 0.67 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0001131.1 |  | 0.67 | NRP | ambactin | Xenorhabdus miraniensis
BGC0001844.1 |  | 0.67 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001615.1 |  | 0.66 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0000301.1 |  | 0.66 | NRP | anabaenopeptin 908, anabaenopeptin 915 | Planktothrix agardhii NIVA-CYA 126/8

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 3, location 1869928 - 1947473:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (glu - D-orn) + (tyr - D-thr) + (glu - D-val) + (pro - glu - D-tyr) + (ile)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_1877: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (13..445): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      N/A
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      gclhIAApvK
    Nearest Stachelhaus code:
      phe
    Stachelhaus code match:
      40% (weak)
ctg1_1883: ile
  Search NORINE for peptide: strict or relaxed
  AMP-binding (474..867): ile
  NRPSPredictor2: ile
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      ile
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAFFYGITFK
    Nearest Stachelhaus code:
      ile
    Stachelhaus code match:
      100% (strong)
ctg1_1884: pro - glu - tyr
  Search NORINE for peptide: strict or relaxed
  AMP-binding (468..864): pro
  NRPSPredictor2: pro
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      pro, pip
    Small clusters prediction:
      pro
    Single AA prediction:
      pro
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVQFIAHVVK
    Nearest Stachelhaus code:
      pro
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1499..1900): glu
  NRPSPredictor2: glu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      glu, gln
    Single AA prediction:
      glu
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAWHFGSVEK
    Nearest Stachelhaus code:
      glu
    Stachelhaus code match:
      100% (strong)
  AMP-binding (2538..2931): tyr
  NRPSPredictor2: tyr
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aromatic
    Large clusters prediction:
      phe, trp, phg, tyr, bht
    Small clusters prediction:
      tyr, bht
    Single AA prediction:
      tyr
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DGTITAEVAK
    Nearest Stachelhaus code:
      tyr
    Stachelhaus code match:
      100% (strong)
ctg1_1885: glu - val
  Search NORINE for peptide: strict or relaxed
  AMP-binding (469..867): glu
  NRPSPredictor2: glu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      glu, gln
    Single AA prediction:
      glu
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAWHFGGVDK
    Nearest Stachelhaus code:
      glu
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1507..1902): val
  NRPSPredictor2: val
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      val
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVFWIGGTFK
    Nearest Stachelhaus code:
      val
    Stachelhaus code match:
      100% (strong)
ctg1_1886: tyr - thr
  Search NORINE for peptide: strict or relaxed
  AMP-binding (474..865): tyr
  NRPSPredictor2: tyr
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aromatic
    Large clusters prediction:
      phe, trp, phg, tyr, bht
    Small clusters prediction:
      tyr, bht
    Single AA prediction:
      tyr
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DGTLTAEVAK
    Nearest Stachelhaus code:
      tyr
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1505..1903): thr
  NRPSPredictor2: thr
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      thr
    Single AA prediction:
      thr
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DFWNIGMVHK
    Nearest Stachelhaus code:
      thr
    Stachelhaus code match:
      100% (strong)
ctg1_1887: glu - orn
  Search NORINE for peptide: strict or relaxed
  AMP-binding (465..863): glu
  NRPSPredictor2: glu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      glu, gln
    Single AA prediction:
      glu
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAWHFGGVDK
    Nearest Stachelhaus code:
      glu
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1502..1908): orn
  NRPSPredictor2: orn
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      orn, lys, arg
    Small clusters prediction:
      orn, horn
    Single AA prediction:
      orn
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVGEIGSIDK
    Nearest Stachelhaus code:
      orn
    Stachelhaus code match:
      100% (strong)

NZ_CP051464.1 - Region 4 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,025,801 - 2,047,699 nt. (total: 21,899 nt) Show pHMM detection rules used
terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001120.1 |  | 0.16 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0001925.1 |  | 0.15 | Alkaloid | altemicidin, SB-203207, SB-203208 | Streptomyces sp.
BGC0001783.1 |  | 0.15 | Other | streptonigrin | Streptomyces flocculus
BGC0001535.1 |  | 0.14 | Other | branched-chain fatty acids | Streptomyces filamentosus
BGC0001313.1 |  | 0.13 | Terpene | arabidiol-baruol | Arabidopsis thaliana
BGC0000313.1 |  | 0.11 | NRP | beauvericin | Beauveria bassiana
BGC0000663.1 |  | 0.08 | Terpene | hopene | Streptomyces coelicolor A3(2)
BGC0001594.1 |  | 0.07 | Alkaloid | fischerindole L | Fischerella muscicola UTEX 1829
BGC0000668.1 |  | 0.06 | Terpene, Alkaloid | 12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole | Hapalosiphon welwitschii UTEX B 1830
BGC0001501.1 |  | 0.06 | Alkaloid | ambiguine P | Fischerella sp. TAU

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001120.1 |  | 0.47 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0001925.1 |  | 0.44 | Alkaloid | altemicidin, SB-203207, SB-203208 | Streptomyces sp.
BGC0001783.1 |  | 0.44 | Other | streptonigrin | Streptomyces flocculus
BGC0001535.1 |  | 0.44 | Other | branched-chain fatty acids | Streptomyces filamentosus
BGC0001313.1 |  | 0.41 | Terpene | arabidiol-baruol | Arabidopsis thaliana
BGC0000313.1 |  | 0.38 | NRP | beauvericin | Beauveria bassiana
BGC0000663.1 |  | 0.30 | Terpene | hopene | Streptomyces coelicolor A3(2)
BGC0001594.1 |  | 0.28 | Alkaloid | fischerindole L | Fischerella muscicola UTEX 1829
BGC0000668.1 |  | 0.27 | Terpene, Alkaloid | 12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole | Hapalosiphon welwitschii UTEX B 1830
BGC0001501.1 |  | 0.27 | Alkaloid | ambiguine P | Fischerella sp. TAU

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP051464.1 - Region 5 - T3PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,094,862 - 2,135,959 nt. (total: 41,098 nt) Show pHMM detection rules used
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T3PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001938.1 |  | 0.24 | Polyketide | entotheonella | Candidatus Entotheonella serta
BGC0001962.1 |  | 0.23 | Polyketide | hierridin B, hierridin C | Cyanobium sp. LEGE 06113
BGC0001831.1 |  | 0.20 | Polyketide | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0001475.1 |  | 0.17 | Polyketide | aspterric acid | Aspergillus terreus NIH2624
BGC0001928.1 |  | 0.16 | Other | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0000867.1 |  | 0.15 | Other | polyhydroxyalkanoic acids | Ectothiorhodospira shaposhnikovii
BGC0000010.1 |  | 0.14 | Polyketide | aflatoxin | Aspergillus flavus
BGC0001882.1 |  | 0.14 | Polyketide | chrysoxanthone A, chrysoxanthone B, chrysoxanthone C | Penicillium rubens Wisconsin 54-1255
BGC0001735.1 |  | 0.14 | Other | pentostatine, vidarabine | Streptomyces antibioticus
BGC0001605.1 |  | 0.13 | Terpene | gibberellin | Sinorhizobium fredii NGR234

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001938.1 |  | 0.57 | Polyketide | entotheonella | Candidatus Entotheonella serta
BGC0001962.1 |  | 0.56 | Polyketide | hierridin B, hierridin C | Cyanobium sp. LEGE 06113
BGC0001831.1 |  | 0.52 | Polyketide | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0001475.1 |  | 0.49 | Polyketide | aspterric acid | Aspergillus terreus NIH2624
BGC0001928.1 |  | 0.47 | Other | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0000867.1 |  | 0.46 | Other | polyhydroxyalkanoic acids | Ectothiorhodospira shaposhnikovii
BGC0000010.1 |  | 0.43 | Polyketide | aflatoxin | Aspergillus flavus
BGC0001882.1 |  | 0.43 | Polyketide | chrysoxanthone A, chrysoxanthone B, chrysoxanthone C | Penicillium rubens Wisconsin 54-1255
BGC0001735.1 |  | 0.43 | Other | pentostatine, vidarabine | Streptomyces antibioticus
BGC0001605.1 |  | 0.42 | Terpene | gibberellin | Sinorhizobium fredii NGR234

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP051464.1 - Region 6 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,046,989 - 3,094,128 nt. (total: 47,140 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000309.1 |  | 0.70 | NRP | bacillibactin | Bacillus subtilis subsp. subtilis str. 168
BGC0001185.1 |  | 0.58 | NRP | bacillibactin | Bacillus velezensis FZB42
BGC0000401.1 |  | 0.55 | NRP | paenibactin | Paenibacillus elgii B69
BGC0001132.1 |  | 0.28 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.1 |  | 0.28 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001825.1 |  | 0.27 | NRP | xenematide | Xenorhabdus nematophila AN6/1
BGC0001844.1 |  | 0.27 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001758.1 |  | 0.27 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001128.1 |  | 0.27 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001149.1 |  | 0.26 | NRP, Saccharide | brabantamide A | Pseudomonas sp. SHC52

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000309.1 |  | 0.89 | NRP | bacillibactin | Bacillus subtilis subsp. subtilis str. 168
BGC0001185.1 |  | 0.83 | NRP | bacillibactin | Bacillus velezensis FZB42
BGC0000401.1 |  | 0.82 | NRP | paenibactin | Paenibacillus elgii B69
BGC0001132.1 |  | 0.62 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.1 |  | 0.61 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001825.1 |  | 0.61 | NRP | xenematide | Xenorhabdus nematophila AN6/1
BGC0001844.1 |  | 0.61 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001758.1 |  | 0.60 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001128.1 |  | 0.60 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001149.1 |  | 0.60 | NRP, Saccharide | brabantamide A | Pseudomonas sp. SHC52

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 6, location 3046988 - 3094128:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (gly - thr)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_3092: gly - thr
  Search NORINE for peptide: strict or relaxed
  AMP-binding (463..861): gly
  NRPSPredictor2: gly
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      gly, ala
    Single AA prediction:
      gly
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DILQLGLIWK
    Nearest Stachelhaus code:
      gly
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1519..1935): thr
  NRPSPredictor2: thr
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      thr
    Single AA prediction:
      thr
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DFWNVGMVHK
    Nearest Stachelhaus code:
      thr
    Stachelhaus code match:
      100% (strong)
ctg1_3094: dhb
  Search NORINE for peptide: strict or relaxed
  AMP-binding (31..435): dhb
  NRPSPredictor2: dhb
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aromatic
    Large clusters prediction:
      dhb, sal
    Small clusters prediction:
      dhb, sal
    Single AA prediction:
      dhb
  Stachelhaus prediction details:
    Stachelhaus sequence:
      PLPAQGVVNK
    Nearest Stachelhaus code:
      dhb
    Stachelhaus code match:
      100% (strong)

NZ_CP051464.1 - Region 7 - lanthipeptide-class-i
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,241,140 - 3,267,365 nt. (total: 26,226 nt) Show pHMM detection rules used
lanthipeptide-class-i: ((LANC_like and (Lant_dehydr_N or Lant_dehydr_C)) and not (YcaO or TIGR03882))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Lanthipeptides
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-i | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000559.1 |  | 0.79 | RiPP | subtilin | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000506.1 |  | 0.66 | RiPP | entianin | Bacillus subtilis subsp. spizizenii
BGC0000511.1 |  | 0.38 | RiPP | ericin S | Bacillus subtilis
BGC0001392.1 |  | 0.28 | RiPP | pinensins | Chitinophaga pinensis DSM 2588
BGC0000542.1 |  | 0.26 | RiPP | paenicidin B | Paenibacillus terrae
BGC0000538.1 |  | 0.26 | RiPP | nisin Z | Lactococcus lactis
BGC0000528.1 |  | 0.26 | RiPP | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001289.1 |  | 0.26 | RiPP | penisin | Paenibacillus ehimensis
BGC0000515.1 |  | 0.26 | RiPP | geobacillin I | Geobacillus thermodenitrificans NG80-2
BGC0000560.1 |  | 0.26 | RiPP | subtilomycin | Bacillus subtilis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000559.1 |  | 0.93 | RiPP | subtilin | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000506.1 |  | 0.87 | RiPP | entianin | Bacillus subtilis subsp. spizizenii
BGC0000511.1 |  | 0.70 | RiPP | ericin S | Bacillus subtilis
BGC0001392.1 |  | 0.62 | RiPP | pinensins | Chitinophaga pinensis DSM 2588
BGC0000542.1 |  | 0.60 | RiPP | paenicidin B | Paenibacillus terrae
BGC0000538.1 |  | 0.60 | RiPP | nisin Z | Lactococcus lactis
BGC0000528.1 |  | 0.60 | RiPP | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001289.1 |  | 0.59 | RiPP | penisin | Paenibacillus ehimensis
BGC0000515.1 |  | 0.59 | RiPP | geobacillin I | Geobacillus thermodenitrificans NG80-2
BGC0000560.1 |  | 0.59 | RiPP | subtilomycin | Bacillus subtilis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Lanthipeptide predictions
Lists the possible core peptides for each biosynthetic enzyme, including the predicted class. Each core peptide shows the leader and core peptide sequences, separated by a dash.

#### Lanthipeptide(s) for ctg1_3279 - Putative Class I

ctg1_3276 leader / core peptide
  MSKFDDFDLDVVKVSKQDSKITPQ - WKDhaEDhaLC DhbPGCVDhbGALQDhb CFLQDhbLDhb CNCKIDhaK

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
Lanthipeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

ctg1_3276 - Class I
  Cleavage pHMM score: 27.80
  RODEO score: 29
  Monoisotopic mass: 3318.6 Da
  Molecular weight: 3320.9 Da
  Number of bridges: 5
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3338.9 Da N = 1
    3357.0 Da N = 2
    3375.0 Da N = 3

NZ_CP051464.1 - Region 8 - CDPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,376,685 - 3,397,431 nt. (total: 20,747 nt) Show pHMM detection rules used
CDPS: (CDPS or cycdipepsynth)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | CDPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001891.1 |  | 0.17 | Other | closthioamide | Ruminiclostridium cellulolyticum H10
BGC0001607.1 |  | 0.16 | Other | gilvusmycin | Streptomyces sp. NRRL B-1347
BGC0001138.1 |  | 0.15 | Other (Nucleoside) | a201a | Marinactinospora thermotolerans
BGC0001540.1 |  | 0.15 | Other | CC-1065 | Streptomyces zelensis
BGC0001140.1 |  | 0.13 | Terpene | platensimycin, platencin | Streptomyces platensis
BGC0001334.1 |  | 0.09 | Alkaloid | caldoniamide A, cladoniamide B, cladoniamide C7, cladoniamide D, cladoniamide E, cladoniamide F, cladoniamide G | Streptomyces uncialis
BGC0001337.1 |  | 0.09 | Alkaloid | lazarimide A, lazarimide B, lazarimide C | uncultured bacterium
BGC0000845.1 |  | 0.08 | Other (Non-NRP beta-lactam) | clavulanic acid | Streptomyces clavuligerus ATCC 27064
BGC0001556.1 |  | 0.08 | NRP, Polyketide | combamide | Streptomyces sp.
BGC0000306.1 |  | 0.08 | NRP | arylomycin | Streptomyces filamentosus NRRL 11379

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001891.1 |  | 0.48 | Other | closthioamide | Ruminiclostridium cellulolyticum H10
BGC0001607.1 |  | 0.46 | Other | gilvusmycin | Streptomyces sp. NRRL B-1347
BGC0001138.1 |  | 0.45 | Other (Nucleoside) | a201a | Marinactinospora thermotolerans
BGC0001540.1 |  | 0.45 | Other | CC-1065 | Streptomyces zelensis
BGC0001140.1 |  | 0.42 | Terpene | platensimycin, platencin | Streptomyces platensis
BGC0001334.1 |  | 0.33 | Alkaloid | caldoniamide A, cladoniamide B, cladoniamide C7, cladoniamide D, cladoniamide E, cladoniamide F, cladoniamide G | Streptomyces uncialis
BGC0001337.1 |  | 0.33 | Alkaloid | lazarimide A, lazarimide B, lazarimide C | uncultured bacterium
BGC0000845.1 |  | 0.32 | Other (Non-NRP beta-lactam) | clavulanic acid | Streptomyces clavuligerus ATCC 27064
BGC0001556.1 |  | 0.32 | NRP, Polyketide | combamide | Streptomyces sp.
BGC0000306.1 |  | 0.31 | NRP | arylomycin | Streptomyces filamentosus NRRL 11379

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP051464.1 - Region 9 - sactipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,640,722 - 3,662,334 nt. (total: 21,613 nt) Show pHMM detection rules used
sactipeptide: (subtilosin or thuricin or TIGR04404 or Subtilosin_A or skfc)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Sactipeptides
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | sactipeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000602.1 |  | 0.66 | RiPP | subtilosin A | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000703.1 |  | 0.19 | Saccharide | kanamycin | Streptomyces kanamyceticus
BGC0001137.1 |  | 0.18 | Alkaloid | marinacarboline A, marinacarboline B, marinacarboline C, marinacarboline D | Marinactinospora thermotolerans
BGC0001496.1 |  | 0.16 | RiPP | actinokineosin | Actinokineospora spheciospongiae
BGC0001655.1 |  | 0.16 | RiPP | LP2006 | Nocardiopsis alba DSM 43377
BGC0000497.1 |  | 0.16 | RiPP | BHT-Aα, BHT-Aβ | Streptococcus ratti
BGC0000552.1 |  | 0.16 | RiPP | SmbA, SmbB | Streptococcus mutans
BGC0000620.1 |  | 0.16 | RiPP | lacticin Q | Lactococcus lactis
BGC0000568.1 |  | 0.15 | RiPP | microcin B17 | Escherichia coli
BGC0000555.1 |  | 0.15 | RiPP | staphylococcin C55 α, staphylococcin C55 β | Staphylococcus aureus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000602.1 |  | 0.87 | RiPP | subtilosin A | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000703.1 |  | 0.51 | Saccharide | kanamycin | Streptomyces kanamyceticus
BGC0001137.1 |  | 0.50 | Alkaloid | marinacarboline A, marinacarboline B, marinacarboline C, marinacarboline D | Marinactinospora thermotolerans
BGC0001496.1 |  | 0.47 | RiPP | actinokineosin | Actinokineospora spheciospongiae
BGC0001655.1 |  | 0.47 | RiPP | LP2006 | Nocardiopsis alba DSM 43377
BGC0000497.1 |  | 0.46 | RiPP | BHT-Aα, BHT-Aβ | Streptococcus ratti
BGC0000552.1 |  | 0.46 | RiPP | SmbA, SmbB | Streptococcus mutans
BGC0000620.1 |  | 0.46 | RiPP | lacticin Q | Lactococcus lactis
BGC0000568.1 |  | 0.46 | RiPP | microcin B17 | Escherichia coli
BGC0000555.1 |  | 0.46 | RiPP | staphylococcin C55 α, staphylococcin C55 β | Staphylococcus aureus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Sactipeptide predictions
Lists the possible core peptides for each biosynthetic enzyme, including the predicted class. Each core peptide shows the leader and core peptide sequences, separated by a dash.

#### Putative Sactipeptide(s)

ctg1_3658 leader / core peptide
  MKKAVIVENK - GCATCSIGAACLVDGPIPDFEIAGATGLFGLWG

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
Sactipeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists its RODEO score and predicted core sequence.

ctg1_3658
  Putative sactipeptide
  RODEO score: 33.0
  Core sequence, approximate: GCATCSIGAACLVDGPIPDFEIAGATGLFGLWG

NZ_CP051464.1 - Region 10 - other
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,665,123 - 3,706,541 nt. (total: 41,419 nt) Show pHMM detection rules used
other: (LmbU or Neocarzinostat or fom1 or bcpB or frbD or mitE or vlmB or prnB or CaiA or bacilysin or orf2_PTase)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | other | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000888.1 |  | 0.58 | Other | bacilysin | Bacillus sp. CS93
BGC0001184.1 |  | 0.57 | Other | bacilysin | Bacillus velezensis FZB42
BGC0000825.1 |  | 0.27 | Alkaloid | staurosporine | Streptomyces sp. TP-A0274
BGC0000813.1 |  | 0.27 | Alkaloid | K-252a | Nonomuraea longicatena
BGC0000245.1 |  | 0.21 | Polyketide | medermycin | Streptomyces sp. AM-7161
BGC0000214.1 |  | 0.21 | Polyketide | cosmomycin B | Streptomyces olindensis
BGC0000724.1 |  | 0.19 | Saccharide | streptomycin | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000194.1 |  | 0.19 | Polyketide | actinorhodin | Streptomyces coelicolor A3(2)
BGC0000827.1 |  | 0.19 | Alkaloid | staurosporine | Salinispora arenicola CNS-205
BGC0000253.1 |  | 0.19 | Polyketide | oviedomycin | Streptomyces antibioticus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000888.1 |  | 0.83 | Other | bacilysin | Bacillus sp. CS93
BGC0001184.1 |  | 0.82 | Other | bacilysin | Bacillus velezensis FZB42
BGC0000825.1 |  | 0.61 | Alkaloid | staurosporine | Streptomyces sp. TP-A0274
BGC0000813.1 |  | 0.60 | Alkaloid | K-252a | Nonomuraea longicatena
BGC0000245.1 |  | 0.54 | Polyketide | medermycin | Streptomyces sp. AM-7161
BGC0000214.1 |  | 0.54 | Polyketide | cosmomycin B | Streptomyces olindensis
BGC0000724.1 |  | 0.52 | Saccharide | streptomycin | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000194.1 |  | 0.51 | Polyketide | actinorhodin | Streptomyces coelicolor A3(2)
BGC0000827.1 |  | 0.51 | Alkaloid | staurosporine | Salinispora arenicola CNS-205
BGC0000253.1 |  | 0.51 | Polyketide | oviedomycin | Streptomyces antibioticus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names