LOCUS       c00093_NZ_LUHG..       10831 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_LUHG01000061.1 Hydrotalea flava strain CCUG 51397
            94_A2_NODE_23_length_51291_cov_268.919_ID_45, whole genome shotgun
            sequence.
ACCESSION   NZ_LUHG01000061
VERSION     NZ_LUHG01000061
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 13:37:16
            Original ID  :: NZ_LUHG01000061.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 32289
            Orig. end    :: 43120
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10831
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[37289:38120](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5831)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10831
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10831
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(485..1309)
                     /locus_tag="ctg93_30"
                     /transl_table=11
                     /translation="MMQRIIVFSLLALTVWACHPVKKVQSIEKAISKKDTAQIVIVTEA
                     PKVDSAAIVKEIMEKVMKHSIDFNTFNAKVKVDYEGPEESQHVNAYLSMIKDSVIYVKM
                     AIPPYGVVANVLVTPDSVILIRLKGGKSIQYRSIAYLQEVTQIPFDFSTLQDLIVGNPV
                     FLDSNVVSYKSGNKQLLVLMVGNMFKHLVTLDNTDFRVLHSKLDDVDIQRNRTCDITFS
                     NYQPVNNFLFATFRQISVAEKSKLDIFLDFKEFSFNEPLKYTFSVPKNYRVK"
     PFAM_domain     complement(491..1114)
                     /aSDomain="DUF4292"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF14125.8"
                     /description="Domain of unknown function (DUF4292)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg93_30_0001"
                     /evalue="1.80E-33"
                     /label="ctg93_30"
                     /locus_tag="ctg93_30"
                     /protein_end="273"
                     /protein_start="65"
                     /score="116.1"
                     /tool="antismash"
                     /translation="IDFNTFNAKVKVDYEGPEESQHVNAYLSMIKDSVIYVKMAIPPYG
                     VVANVLVTPDSVILIRLKGGKSIQYRSIAYLQEVTQIPFDFSTLQDLIVGNPVFLDSNV
                     VSYKSGNKQLLVLMVGNMFKHLVTLDNTDFRVLHSKLDDVDIQRNRTCDITFSNYQPVN
                     NFLFATFRQISVAEKSKLDIFLDFKEFSFNEPLKYTFSVPKNYRV"
     CDS             complement(1316..1759)
                     /locus_tag="ctg93_31"
                     /transl_table=11
                     /translation="MQKIEVTITNSSHHPLPTYATVGSSGMDLRAFIPQPITLLPLERI
                     LIPTGLQIALPEGLEAQVRPRSGLAIQQGITCLNTPGTIDADYRGEIKVILINLSNHPV
                     TIQDGDRIAQMVIQRVEQISWIPTEVLSETERGVGGFGHTGKQ"
     aSDomain        complement(1322..1732)
                     /aSDomain="TIGR00576"
                     /aSTool="tigrfam"
                     /description="dut: dUTP diphosphatase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg93_31_0001"
                     /evalue="2.20E-52"
                     /identifier="TIGR00576"
                     /label="ctg93_31"
                     /locus_tag="ctg93_31"
                     /protein_end="146"
                     /protein_start="9"
                     /score="174.6"
                     /tool="antismash"
                     /translation="NSSHHPLPTYATVGSSGMDLRAFIPQPITLLPLERILIPTGLQIA
                     LPEGLEAQVRPRSGLAIQQGITCLNTPGTIDADYRGEIKVILINLSNHPVTIQDGDRIA
                     QMVIQRVEQISWIPTEVLSETERGVGGFGHTGK"
     PFAM_domain     complement(1325..1720)
                     /aSDomain="dUTPase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00692.21"
                     /description="dUTPase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg93_31_0002"
                     /evalue="1.40E-31"
                     /label="ctg93_31"
                     /locus_tag="ctg93_31"
                     /protein_end="145"
                     /protein_start="13"
                     /score="108.9"
                     /tool="antismash"
                     /translation="HPLPTYATVGSSGMDLRAFIPQPITLLPLERILIPTGLQIALPEG
                     LEAQVRPRSGLAIQQGITCLNTPGTIDADYRGEIKVILINLSNHPVTIQDGDRIAQMVI
                     QRVEQISWIPTEVLSETERGVGGFGHTG"
     CDS             complement(1943..3316)
                     /locus_tag="ctg93_32"
                     /transl_table=11
                     /translation="MLQLKNNKYKHMKKIMKTVAPFLMAMVFMVACKPKNAYEKITHDP
                     MLYTQMQHELNYVIIYDIFTPPVASRVFAYSNLAAYEVLAKEGKHFETLEGKIKDLDSI
                     PAPTAEEKTAIDYPFAATLAFLKVGKELTFSQDKMQHITDSLLDVVRQSGMPDKMYTSS
                     VAYATTVANAIIRWSKKDNYAQTRGARFTVTNLEGHWEPTPPGYFDAVEPKWMTIRTLV
                     MDSAGQIKAPGPIPFSKQPGSPFYKMAQQVQETGNHLDSNQKWIANFWDCNSFKLHVQG
                     HLMFATKAMTPCGHWMEIAGTIAKNKNADFYKTVYTYTGVSLGIFDAFIASWYAKYTYD
                     LVRPETFINKYIDPNWKPYLQTPPFPEYNSAHSTISSASAAVLKTIYGNETPFRDSSER
                     NWGWPDRSFPSLDSAAREVSMSRFYGGIHYLPSVWDAYAQGKEIGLIVMSKLLKNYKE"
     PFAM_domain     complement(2027..2353)
                     /aSDomain="PAP2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01569.23"
                     /description="PAP2 superfamily"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg93_32_0003"
                     /evalue="1.70E-06"
                     /label="ctg93_32"
                     /locus_tag="ctg93_32"
                     /protein_end="430"
                     /protein_start="321"
                     /score="27.9"
                     /tool="antismash"
                     /translation="SLGIFDAFIASWYAKYTYDLVRPETFINKYIDPNWKPYLQTPPFP
                     EYNSAHSTISSASAAVLKTIYGNETPFRDSSERNWGWPDRSFPSLDSAAREVSMSRFYG
                     GIHYL"
     CDS             complement(3668..4138)
                     /locus_tag="ctg93_33"
                     /transl_table=11
                     /translation="MKNSINTLCTKYLNGATKAGSFPLLLIRLVLAYGFLGPATMKWND
                     IHAVGDWFGTLGIPAPHFNAYLAATTESIGVILLLLGLGTRFIAIPLIIVMLVAIRTAH
                     WGNGFEAGNNGFEIPLYYIIMLLTLISFGAGKFSIDYLLAKKTSTKKMSITS"
     PFAM_domain     complement(3824..4069)
                     /aSDomain="DoxX"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07681.14"
                     /description="DoxX"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg93_33_0004"
                     /evalue="4.40E-17"
                     /label="ctg93_33"
                     /locus_tag="ctg93_33"
                     /protein_end="105"
                     /protein_start="23"
                     /score="62.6"
                     /tool="antismash"
                     /translation="LLLIRLVLAYGFLGPATMKWNDIHAVGDWFGTLGIPAPHFNAYLA
                     ATTESIGVILLLLGLGTRFIAIPLIIVMLVAIRTAHW"
     CDS             complement(4262..5014)
                     /locus_tag="ctg93_34"
                     /transl_table=11
                     /translation="MQPYNLTQSYQSQLAGYCRTGQWNHIPGVHTGHVQQYRRLVYNVI
                     DDMLRNAFPVMSELVTKQEWDEVVQFFFSSHSCHSPQVWYMPKEFYQFVLNSQHALLQQ
                     YPCLAALMQYEWMEVELFMMEDRTVPHTTLGDVVFSKLVLNPEHTLMALPYPVHQKKAT
                     AITKADKGNYFIAGYRNTNGDVLFTDLSPALVRMIEYLSVTPLSVKQLIEQLESEFQLI
                     LTETDKQAVIQFFETAYMQQLIIGFADN"
     PFAM_domain     complement(4733..4987)
                     /aSDomain="DUF2063"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09836.11"
                     /description="Putative DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg93_34_0005"
                     /evalue="1.20E-14"
                     /label="ctg93_34"
                     /locus_tag="ctg93_34"
                     /protein_end="94"
                     /protein_start="9"
                     /score="54.4"
                     /tool="antismash"
                     /translation="YQSQLAGYCRTGQWNHIPGVHTGHVQQYRRLVYNVIDDMLRNAFP
                     VMSELVTKQEWDEVVQFFFSSHSCHSPQVWYMPKEFYQFV"
     CDS             complement(5001..5831)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg93_35"
                     /sec_met_domain="DUF692 (E-value: 6.4e-103, bitscore:
                     335.3, seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVGIGYRKDFAADFAESNTLHPAFIEVAPENWIGVGGYWKKQFQK
                     ALEKYPLFTHGLSLSIGSPDPLDFVFLKQVKKFLQQTNAVLYSEHLSYAKCDNAHLYDL
                     LPIPFTEAAVHHVAENIKQVQDFLERKIAIEIVSYYTPVAPELTEIDFINAILEEANCD
                     LLLDVNNVYVNSFNHQYDAKTFIAQLPMQRVKYIHMAGHEKVADDLIIDTHGEAIIDPV
                     YDLFAFTIQQLQRDVPVLLERDFNIPELHELQYELNKLNQIKQQALQPAIYATL"
     PFAM_domain     complement(5040..5828)
                     /aSDomain="DUF692"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05114.15"
                     /description="Protein of unknown function (DUF692)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg93_35_0006"
                     /evalue="1.90E-97"
                     /label="ctg93_35"
                     /locus_tag="ctg93_35"
                     /protein_end="264"
                     /protein_start="1"
                     /score="325.7"
                     /tool="antismash"
                     /translation="VGIGYRKDFAADFAESNTLHPAFIEVAPENWIGVGGYWKKQFQKA
                     LEKYPLFTHGLSLSIGSPDPLDFVFLKQVKKFLQQTNAVLYSEHLSYAKCDNAHLYDLL
                     PIPFTEAAVHHVAENIKQVQDFLERKIAIEIVSYYTPVAPELTEIDFINAILEEANCDL
                     LLDVNNVYVNSFNHQYDAKTFIAQLPMQRVKYIHMAGHEKVADDLIIDTHGEAIIDPVY
                     DLFAFTIQQLQRDVPVLLERDFNIPELHELQYELNKLNQIK"
     CDS             complement(5908..6189)
                     /locus_tag="ctg93_36"
                     /transl_table=11
                     /translation="MENKKSILAGSILAGALLTVAGINANASSLIRYNHVTSADEVIAG
                     LHAKDVSNNNFELKCGATKKSDTTKTKKKGKDGKCGEGKCGSTKKSGN"
     CDS             6459..6674
                     /locus_tag="ctg93_37"
                     /transl_table=11
                     /translation="MYYYLYPFHQPAAIHLSLCFGVGNVHRGRKDLNVILILFFLSMTG
                     ASVIFFQSIPLLLNRKPSMTALPSAS"
     CDS             complement(6745..7344)
                     /gene_functions="regulatory (smcogs) SMCOG1032:RNA
                     polymerase, sigma-24 subunit, ECF subfamily (Score: 82.9;
                     E-value: 3.6e-25)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg93_38"
                     /transl_table=11
                     /translation="MDNVMDLQNKTATIQCWVAQYTDTLFQWAWHKTSDKALAEDLVQD
                     TFLSAVESFHTFQGKSQPKTWLFSILNIKIANHFRKCFKMPEVSWQDELLQRGDDLIES
                     FFDENGHWRMNEIRKDNWQDADLHLLDIPEFATVLNNCMDKLPKHWFSALHLKYLEAKS
                     GEEICQELQISTTNFWQIIHRAKLQLRKCLDVHWFK"
     aSDomain        complement(6766..7293)
                     /aSDomain="TIGR02937"
                     /aSTool="tigrfam"
                     /description="sigma70-ECF: RNA polymerase sigma factor,
                     sigma-70 family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg93_38_0002"
                     /evalue="1.10E-19"
                     /identifier="TIGR02937"
                     /label="ctg93_38"
                     /locus_tag="ctg93_38"
                     /protein_end="193"
                     /protein_start="17"
                     /score="68.6"
                     /tool="antismash"
                     /translation="VAQYTDTLFQWAWHKTSDKALAEDLVQDTFLSAVESFHTFQGKSQ
                     PKTWLFSILNIKIANHFRKCFKMPEVSWQDELLQRGDDLIESFFDENGHWRMNEIRKDN
                     WQDADLHLLDIPEFATVLNNCMDKLPKHWFSALHLKYLEAKSGEEICQELQISTTNFWQ
                     IIHRAKLQLRKCL"
     PFAM_domain     complement(7102..7296)
                     /aSDomain="Sigma70_r2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04542.16"
                     /description="Sigma-70 region 2"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg93_38_0007"
                     /evalue="1.90E-12"
                     /label="ctg93_38"
                     /locus_tag="ctg93_38"
                     /protein_end="81"
                     /protein_start="16"
                     /score="46.8"
                     /tool="antismash"
                     /translation="WVAQYTDTLFQWAWHKTSDKALAEDLVQDTFLSAVESFHTFQGKS
                     QPKTWLFSILNIKIANHFRK"
     CDS             complement(7417..8124)
                     /locus_tag="ctg93_39"
                     /transl_table=11
                     /translation="MHQLLGEYLGTALLILLGNGVVANVNLKHTYAHGGGWIVITFGWA
                     MAVFVGVFVASKASGGHLNPAFTIALAAIGKFSWQLVPGYIAAQILGAMTGSLLVWLTF
                     YKHYALPNDAGTIKATFCTEPAIRKYGWNLITEIIGAFVLVFSVFKMSAPAQSLGTLDA
                     LPVAFIVLAIGLSLGGVTGYAINPARDLGPRIMHALLPIPGKGTTDWQYSWVPIVGPII
                     GALLAAFVFELIT"
     aSDomain        complement(7432..8106)
                     /aSDomain="TIGR00861"
                     /aSTool="tigrfam"
                     /description="MIP: MIP family channel proteins"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg93_39_0003"
                     /evalue="4.90E-56"
                     /identifier="TIGR00861"
                     /label="ctg93_39"
                     /locus_tag="ctg93_39"
                     /protein_end="231"
                     /protein_start="6"
                     /score="188.0"
                     /tool="antismash"
                     /translation="EYLGTALLILLGNGVVANVNLKHTYAHGGGWIVITFGWAMAVFVG
                     VFVASKASGGHLNPAFTIALAAIGKFSWQLVPGYIAAQILGAMTGSLLVWLTFYKHYAL
                     PNDAGTIKATFCTEPAIRKYGWNLITEIIGAFVLVFSVFKMSAPAQSLGTLDALPVAFI
                     VLAIGLSLGGVTGYAINPARDLGPRIMHALLPIPGKGTTDWQYSWVPIVGPIIGALLAA
                     FVF"
     PFAM_domain     complement(7432..8121)
                     /aSDomain="MIP"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00230.22"
                     /description="Major intrinsic protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg93_39_0008"
                     /evalue="8.60E-48"
                     /label="ctg93_39"
                     /locus_tag="ctg93_39"
                     /protein_end="231"
                     /protein_start="1"
                     /score="163.1"
                     /tool="antismash"
                     /translation="HQLLGEYLGTALLILLGNGVVANVNLKHTYAHGGGWIVITFGWAM
                     AVFVGVFVASKASGGHLNPAFTIALAAIGKFSWQLVPGYIAAQILGAMTGSLLVWLTFY
                     KHYALPNDAGTIKATFCTEPAIRKYGWNLITEIIGAFVLVFSVFKMSAPAQSLGTLDAL
                     PVAFIVLAIGLSLGGVTGYAINPARDLGPRIMHALLPIPGKGTTDWQYSWVPIVGPIIG
                     ALLAAFVF"
     CDS             complement(8195..9754)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1103:FAD dependent oxidoreductase (Score: 81.7;
                     E-value: 9.9e-25)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg93_40"
                     /transl_table=11
                     /translation="MKREKMIQNIRATPHWDVVIIGGGATGLGTAVDAATRGYSTLLVE
                     QFDFAKGTSSRSTKLVHGGVRYLAQGNLSLVMHALKERGRLLRNAPHLAHTQQFIVPVY
                     SFWKKWLYFLGLTFYDFLSIGWGIGRTRLLSKKKTIAALPLIKTGNLKGGIQYTDGQFD
                     DSRLCIDLAATAHRYGATVLNYAAAASFTKNESGQLTGVVIQDHINGEKYTVTANAIIN
                     ATGVFAHSVMEIDDPEMPDSIAPSQGVHLVIDMEKFQSTQALMVPKTTDGRVLFAVPWH
                     HKVIVGTTDTPVEQISTEPKPLEEEIQFIIDNYNIYASNPISMRDVKSVYVGLRPLVRK
                     KGARKNTSMISRDHTIMVSASGLITITGGKWTTYRRMAADVINHAIQLGKLTKKPAVTA
                     TLPIGKWGWPIDFSTHWHLYGTNARLIQDIMKENKEWASQLHPDYPYTQAEVIWFVRNE
                     MAQTIEDVLARRIRLLLLDAKAAVEGAPIVAALMQKELNHTKEWKEAQILNFSNLAKQY
                     IL"
     PFAM_domain     complement(8252..8536)
                     /aSDomain="DAO_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF16901.7"
                     /description="C-terminal domain of alpha-glycerophosphate
                     oxidase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg93_40_0010"
                     /evalue="2.90E-24"
                     /label="ctg93_40"
                     /locus_tag="ctg93_40"
                     /protein_end="501"
                     /protein_start="406"
                     /score="85.4"
                     /tool="antismash"
                     /translation="GWPIDFSTHWHLYGTNARLIQDIMKENKEWASQLHPDYPYTQAEV
                     IWFVRNEMAQTIEDVLARRIRLLLLDAKAAVEGAPIVAALMQKELNHTKE"
     PFAM_domain     complement(8630..9706)
                     /aSDomain="DAO"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01266.26"
                     /description="FAD dependent oxidoreductase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg93_40_0009"
                     /evalue="2.70E-49"
                     /label="ctg93_40"
                     /locus_tag="ctg93_40"
                     /protein_end="375"
                     /protein_start="16"
                     /score="168.7"
                     /tool="antismash"
                     /translation="DVVIIGGGATGLGTAVDAATRGYSTLLVEQFDFAKGTSSRSTKLV
                     HGGVRYLAQGNLSLVMHALKERGRLLRNAPHLAHTQQFIVPVYSFWKKWLYFLGLTFYD
                     FLSIGWGIGRTRLLSKKKTIAALPLIKTGNLKGGIQYTDGQFDDSRLCIDLAATAHRYG
                     ATVLNYAAAASFTKNESGQLTGVVIQDHINGEKYTVTANAIINATGVFAHSVMEIDDPE
                     MPDSIAPSQGVHLVIDMEKFQSTQALMVPKTTDGRVLFAVPWHHKVIVGTTDTPVEQIS
                     TEPKPLEEEIQFIIDNYNIYASNPISMRDVKSVYVGLRPLVRKKGARKNTSMISRDHTI
                     MVSASGLITITGGKWTTYR"
ORIGIN
        1 aatctctggc agaaaacaaa aagtttaagt attcataact gcttctattc ttataagcaa
       61 aaacaatgct tttggcatag ttttgtttca gtgtatccaa ttgcctcttt aaacggttta
      121 tttctaattg tttatcataa atatcatcat tcaatcgttg aatttcctga ttaattttat
      181 gaatgagccg ttcccgaaca gctaattttc gctgtaaaat tgctacttcg gtgatggatt
      241 gttttttgtt tttacgaata gaattcaatg cggcattcaa attatcaatt tcttcctgca
      301 attgcttttg ctgctgctgc aacgcttcac gggtaggggg ctgatatgtg ccctgtgttt
      361 gggcagataa ctgcaagaag gaaaaaacaa aaaaacacaa caataataac cgcattatac
      421 aattctcatt tttaaataga aaatagaatg aatatggttg aataacgaac ctgccacctt
      481 aatattattt cacccgataa tttttaggca ccgaaaaggt atactttaac ggctcattaa
      541 atgaaaactc tttaaaatct aaaaatatat ccagcttcga tttttcagca acagagattt
      601 gccgaaaggt agcaaataaa aaattattga ccggctgata attgctaaaa gtaatatcgc
      661 aggttcggtt gcgttgaata tcaacatcat ctaacttact gtgtaatacc ctgaaatcag
      721 tattatctaa tgttaccaga tgtttaaaca tattaccaac cattaaaacc agcaattgct
      781 tattacccga tttatatgaa accacattgc tatctaaaaa aaccggattt ccaacaatta
      841 aatcctgcag cgttgaaaaa tcaaatggaa tttgtgttac ttcctgtaaa tatgcaatgc
      901 ttcggtattg aatggatttg ccgcctttta atctaatcag aataacacta tcgggggtta
      961 ccaatacatt ggccacaacg ccataaggtg ggatggccat ttttacataa atcacactat
     1021 cttttatcat gctgagataa gcattcacat gctggctttc ttccggcccc tcataatcta
     1081 cttttacttt agcattgaat gtgttgaaat caatggaatg tttcattact ttttccataa
     1141 tttctttcac aatggcagct gagtcaacct ttggcgcttc ggtaacaatc actatctgtg
     1201 ccgtatcttt tttagagatg gctttttcaa tagattgtac tttttttaca ggatggcagg
     1261 cccaaaccgt taaagcaagc aggctaaaaa caattattct ttgcatcata ttacattact
     1321 gtttaccggt atggccaaaa ccgcccacac ctctttctgt ttcagataat acttctgtgg
     1381 gtatccagct aatttgttcc actcgctgaa ttaccatttg tgcaattcta tcgccatcct
     1441 gaatggttac cgggtggttc gacaggttga ttaaaattac ttttatttct cctctgtaat
     1501 cggcatcaat ggtacccggt gtatttaagc aagtgatacc ctgttgaata gccaagccgc
     1561 ttctgggcct tacttgggct tctaatcctt ccggcaatgc tatttgtaaa ccggttggaa
     1621 ttaatatccg ttctagtggg agtaaagtaa tgggttgggg aatgaaggcc cttaaatcca
     1681 tgcctgaaga accaactgta gcataagttg gtaatgggtg gtgtgatgaa ttggtaatgg
     1741 ttacctctat tttttgcatg caacgaaggt aggagtttgc gctaaaaaag cagaaaggat
     1801 aggcttaaaa gtaaacaggt tttaatgagt aggaaacaaa catgcaagcc ccgggcaaat
     1861 aattgttgct gtaatagcca aaataaaatg gccactcttt tctaaatttg aaaaagtggc
     1921 cattcccaaa aaatgattcg gattattctt tgtaattttt taacaattta ctcattacaa
     1981 ttaaaccaat ttctttgccc tgagcataag catcccaaac agagggcagg tagtgtatac
     2041 caccataaaa ccgactcata gacacttcac gggctgcaga atctaatgat gggaaacttc
     2101 tatcgggcca gccccaattt ctttcactgg aatctctgaa tggcgtttca ttgccgtaaa
     2161 tggtttttaa cacagcagcc gatgcacttg atatggtgga gtgtgcgcta ttgtattcag
     2221 gaaacggagg ggtttgtaaa tagggtttcc agttgggatc aatgtactta ttaataaagg
     2281 tttcgggtct taccaaatcg taagtatatt ttgcatacca ggaagcaata aacgcatcga
     2341 atatacccaa tgaaacaccg gtgtaggtgt acacggtttt atagaaatcg gcatttttat
     2401 ttttggcaat ggtacctgca atttccatcc aatgtccaca aggtgtcatg gctttggttg
     2461 caaacatgag gtgaccctgt acatgcaatt taaagctgtt acaatcccaa aaattggcaa
     2521 tccatttttg gttagaatct aaatgattgc cggtttcctg cacttgttgt gccattttgt
     2581 aaaaggggct gccgggttgt ttactgaatg gaatgggccc gggtgctttg atctggccgg
     2641 ctgaatccat caccagggtt cttatagtca tccacttggg ttctactgca tcaaaatagc
     2701 cgggtggagt gggttcccaa tgtccttcca aattggtaac agtaaatctt gcgccacggg
     2761 tttgtgcata attatctttt ttactccaac gaataatggc attggcaaca gttgttgcat
     2821 aagccactga gctggtgtac attttatccg gcatgcccga ctggcgtact acatctaaca
     2881 acgaatcggt aatgtgttgc attttatctt gcgaaaaagt taactccttc cctactttta
     2941 aaaatgcaag ggttgcagca aagggataat ctatagcagt tttttcttca gcagttggcg
     3001 caggaatact atctaaatct ttaatttttc cttccagcgt ttcaaaatgt tttccttcct
     3061 ttgccaatac ttcataagct gccaaattgg agtaggcaaa tacacgagag gctaccggag
     3121 gagtaaaaat atcatagata attacataat ttaactcatg ctgcatttgg gtgtacaaca
     3181 tggggtcatg cgtaattttt tcatacgcat ttttaggttt gcatgctacc atgaatacca
     3241 ttgccattag aaaaggtgca accgttttca ttattttttt catgtgttta tatttattat
     3301 tttttaattg taacataaaa ttcgcctatt atcatcccga ttgttattaa agatgatatg
     3361 attataactc atttcaccat tatttttttg aataccattt aaaaaagaaa aaccatgagc
     3421 attcatcaca tgatatatgc gataatcctc atagttcatc taactttcat tttgctgcaa
     3481 accatcttaa aaaaaataga atgttttaat gagtgtgctg caaaacgagc aataaatata
     3541 agtacatttc agaaaatcat aaaaaaaagg taataaaatg cacttaaact acccttttga
     3601 aaccaatttt aaattttgag aaccgatatc tattgttaat tgtacaagct gtttatctaa
     3661 aaatttatca tgaagtgatg gacatttttt tagtagatgt ttttttagca agtaggtaat
     3721 ctatactaaa cttacccgca ccaaaactaa ttaaggtaag taacataatg atataataca
     3781 atggaatttc aaaaccatta tttcctgctt caaacccatt gccccaatgg gcagtgcgaa
     3841 tggccaccag cattacaatg atcagcggaa tggcaataaa acgcgtaccc aaacccagca
     3901 gcaataaaat tacaccaata ctctcggtag tagcggctaa atatgcgttg aaatgcggtg
     3961 caggaatacc cagggttcca aaccaatcgc ctactgcatg tatatcgttc cacttcatgg
     4021 tggcaggacc caaaaaacca taagccaata ccaaccgaat caacagcaaa ggaaatgaac
     4081 ccgcttttgt ggctccattc aaatattttg tgcacagggt attgattgaa tttttcatgt
     4141 ttttttgatt aaatagttgt tgatgaatga aaagtttaaa cggagttttt gctttattgt
     4201 aaagcggttt cccattgtat cgggttactt tctatttatg caggaaaaaa attaatagca
     4261 atcagttatc tgcaaatcca ataatcaatt gctgcatata cgctgtttca aaaaactgta
     4321 ttacggcctg tttatcagtt tcagttaata tcaattgaaa ttcactttct aattgctcta
     4381 ttaactgctt tacagaaagt ggtgttactg acaggtattc tatcatacgc accaatgcag
     4441 gcgagagatc ggtaaataat acatcgccat tggtatttct gtagccagct ataaaataat
     4501 tgcctttgtc ggctttggtt atggctgttg cttttttttg atgtaccgga tagggcaatg
     4561 ccattaaagt atgttcagga tttaatacta atttactaaa taccacatca cccaatgtag
     4621 tatggggtac cgttctgtct tccatcataa acaattcaac ctccatccac tcatattgca
     4681 taagcgctgc cagacaggga tattgttgaa gcaatgcgtg ttgactattc aaaacaaact
     4741 gataaaattc tttgggcata taccaaacct gcggagaatg gcaggaatgg ctactgaaaa
     4801 aaaactgcac tacttcatcc cattcttgtt tagtaaccag ttcactcata acgggaaagg
     4861 cattgcgtaa catatcatct attacattgt ataccaacct tctatattgt tgtacatggc
     4921 cggtatgtac acccggaata tgattccatt gtccggttct gcaatacccg gctaattggc
     4981 tttgatagct ttgagtaaga ttataaggtt gcatatatag ctggttgtaa ggcttgttgt
     5041 ttaatttggt tgagtttatt taattcatat tgcagttcat gcaattcagg tatattaaaa
     5101 tcacgttcca atagtaccgg cacatcgcgt tgcaactgct gtatggtaaa agcaaacaaa
     5161 tcatacacag gatctatgat agcttctcca tgcgtatcta taattaaatc atcggcaact
     5221 ttttcgtgcc ccgccatgtg aatatatttt acccgttgca taggtaattg tgcaataaat
     5281 gttttagcat cgtactgatg attaaagcta ttgacataca cattattcac atcgagtaac
     5341 aaatcgcaat tcgcttcttc cagaatagca ttaataaaat ctatttcagt tagttcaggc
     5401 gcaacaggtg tgtaataact tacaatttca atggctattt ttctctccag aaaatcctgt
     5461 acctgtttaa tattttcagc aacatgatgc actgctgctt cggtaaaagg tatgggcaat
     5521 aaatcgtata aatgtgcatt atcacatttg gcataactga gatgctctga atatagcaca
     5581 gcattggttt gttgcaaaaa cttttttacc tgctttaaaa aaacaaaatc taacggatcc
     5641 gggctaccaa tagaaagtga caacccatgc gtaaacagag gatatttttc caatgctttt
     5701 tgaaattgtt ttttccaata gccacccact cctatccagt tttcaggtgc tacttctata
     5761 aatgcaggat gcagggtgtt gctttcagca aaatcggctg caaaatcttt tctataacct
     5821 atgcctacca taacatttat ttgtggtgtg aaacaataaa gcaggcaacc ctattcatag
     5881 cgttacctgc ttttgtaaaa cataatttta gttacctgat tttttggtgc tgccgcattt
     5941 gccttcgcca catttaccat cttttccttt tttcttggtt ttagtggtat ctgatttttt
     6001 tgttgcacca cattttaact caaaattgtt attactaaca tcttttgcat gcaggcctgc
     6061 aattacttcg tctgcagaag ttacatgatt gtaacgaatc aggctggatg cattggcatt
     6121 gattccggct actgttaata atgctccggc taaaattgaa ccggcaagga tacttttttt
     6181 gttttccatt ttgtactttt ttaaatgttt aatgaatgct tatacccaat agtcgaagaa
     6241 ttatatacat actgacaaaa tgatgaaaaa aaatttctac ccatcagaaa gcatagtaaa
     6301 aaatgcagaa ttgcaatata cgctacgtca aaaatgaaac aaaaagtgtt tcctgtctaa
     6361 aaaagaaggt gggtagcaca acttgtaata aaattatttt tgttattcgc ggagaggaag
     6421 gactttgaga atgcgttctt ttaatgaagt attatcagat gtactattat ctgtatccgt
     6481 ttcatcagcc tgcagccatt catctatcac tttgctttgg tgttggtaat gtacacagag
     6541 gtcgcaaaga cttaaatgta attttaattt tattttttct gtccatgaca ggggcatcag
     6601 tgattttttt tcaatcaatt ccgttgcttt taaacaggaa accatcaatg accgcattac
     6661 cttctgcttc ataaatttat ttttactgca tatgattcaa aaaattaaaa ctgattacat
     6721 tatttattta taagaaggta ctgattattt aaaccaatgt acatctaaac attttcgcaa
     6781 ctgtaattta gccctgtgta ttatttgcca aaaattagta gtagaaatct gcaattcctg
     6841 acaaatttcc tctccacttt ttgcctctaa atattttaaa tgtaaagccg aaaaccagtg
     6901 tttgggcaat ttatccatac aattgttcag cactgttgca aattctggaa tatctaacaa
     6961 atgcaaatcg gcatcctgcc aattatcttt ccgtatttcg ttcatgcgcc aatggccatt
     7021 ttcatcaaaa aagctttcaa tcaaatcatc gccacgctgc aataattcat cctgccacga
     7081 tacttccggc attttaaaac atttacggaa atgattggca attttaatgt taagaatact
     7141 gaacaaccag gttttgggtt gacttttgcc ctgaaatgta tggaatgatt ctactgccga
     7201 taaaaaagta tcctgcacca aatcttcggc cagtgcttta tcagaggttt tgtgccaggc
     7261 ccactgaaaa agtgtatcgg tatattgtgc tacccaacat tgtatggttg cggttttatt
     7321 ttgcaggtcc attacattat ccatgtaata aaaatatatt tattttttga taacacaaaa
     7381 tatcgtgcac ttagtatccg gcgctttaag taaattttaa gttataagtt caaaaacaaa
     7441 tgcagccaac aatgcaccaa taatgggccc aacaatgggc acccagctat attgccagtc
     7501 ggtagtgcct ttcccgggaa tgggcaacag ggcatgcatg atacgcggac ccaaatcgcg
     7561 ggccggattg atggcatagc ctgtaacacc ccctaaactt aaaccaatgg ccagtactat
     7621 gaatgccacc ggtaatgcat ctaacgtacc gaggctttgt gcaggagcag acattttgaa
     7681 tacactgaac accaatacaa aagcacctat tatttcagta attaaattcc atccatattt
     7741 tctaatggca ggttcggtgc agaaagttgc tttaattgta cccgcatcat taggtaaagc
     7801 atagtgttta taaaaagtaa gccataccag caacgatcct gtcatggcac ctaaaatttg
     7861 tgcagcaata tagccgggta ccaattgcca actaaattta cctatggctg ctaatgcaat
     7921 ggtaaaagca ggatttaaat gcccaccgct ggctttagaa gccacaaaaa cccctacaaa
     7981 taccgccatt gcccatccaa aagtaattac tatccaacca ccaccatggg catacgtgtg
     8041 ttttaaattt acattggcaa ctaccccatt acccaataaa attaataaag cagtgcccaa
     8101 atattcgcct aataattgat gcatgaccat ttgcaggatt attttgtttg aatgtaagtt
     8161 gttttgttta gggaaaaata aaagcaagaa ctcattacaa gatatattgt tttgccaaat
     8221 ttgaaaaatt caatatttgc gcctctttcc attcctttgt gtgattgagt tccttctgca
     8281 ttaatgctgc tactattggt gccccctcca cagcagcttt tgcatctaat aataataagc
     8341 gtattcttcg tgccaacaca tcctctatgg tttgtgccat ttcatttcga acaaaccaaa
     8401 ttacttcagc ctgtgtatag ggataatcag gatgtaattg gcttgcccat tccttatttt
     8461 ctttcataat atcctgaata aggcgggcat tggtgccata cagatgccag tgggttgaaa
     8521 aatcgatggg ccatccccat ttaccaatgg gtaaagtagc agttacggca ggctttttgg
     8581 ttaatttacc caattgtatg gcatggttga ttacatcggc ggccatacgg cgataggttg
     8641 tccatttacc gccggtaatg gtaattaatc cggaagccga taccataatg gtatgatctc
     8701 tcgatatcat ggaagtattt ttccttgctc cctttttccg aaccaaaggc cgtaaaccaa
     8761 cgtacacgct tttaacatca cgcattgaaa tgggattgct ggcataaata ttataattgt
     8821 caataataaa ctgaatttct tcttctaatg gtttgggttc tgtactaatt tgttcaaccg
     8881 gtgtatcggt agtacccact ataactttgt ggtgccaggg aacggcaaat aatacccgcc
     8941 catcggtggt tttaggcacc atcagtgcct gcgttgattg aaatttttcc atatcaatga
     9001 ccaaatgtac accctgtgaa ggagcaatgg aatcgggcat ttccgggtca tctatttcca
     9061 ttactgaatg ggcaaataca cccgtggcat taataatggc attggcagtt acggtatatt
     9121 tttcgccgtt gatatgatcc tgaattacga ctcctgttaa ttggccgctt tcgttttttg
     9181 taaatgaagc agcagcagca taatttaaaa cagtggcacc ataacggtgt gccgttgctg
     9241 ccaaatctat acacaacctg ctgtcatcaa actgcccatc cgtgtattga atccctcctt
     9301 ttaaattacc ggttttaata agtggcaatg ctgcaatggt tttcttttta gacaataagc
     9361 gggttctgcc aattccccag ccaatcgata aaaaatcgta aaatgtaagg cctaaaaaat
     9421 agagccattt tttccaaaat gaatataccg gtacaataaa ttgctgggtg tgtgccaaat
     9481 gtggcgcatt gcgtaataag cgccctcttt cttttaaagc gtgcattacc aaacttaaat
     9541 taccttgtgc caaataacgt accccaccat gtaccaattt ggtagagcgg ctggaagtgc
     9601 cttttgcaaa atcaaattgt tcaaccagca aagtactgta gcctctggtt gcggcatcca
     9661 cagccgtacc taagccggta gcgcccccac caataattac cacatcccaa tggggcgtag
     9721 cacggatatt ttggatcatt ttttctcttt tcataacatc ccatcgctta atatttaaaa
     9781 aaatttttgc tattgcgtat tattggccca atgaatggta gcccttacag ctctgtgcca
     9841 gccctctaac aaatggttgg tttcagcggc agttgcctgc ggttcaaatg ttctatccat
     9901 ttgccataat gctgctattt ctgctctgct gctgtaaaag ccaacagcca gtccggccaa
     9961 ataagctgca cctaaagcag tggtttcagt aatggccggc tttactactt tgcatcctaa
    10021 cacattgctt tgaaattgca tgagtaactg attggcagta gcgccgccat ctacccttag
    10081 ctcatgaatg gcaataccac tatcggcctc cattgctttt aacacatcta ctgtttggta
    10141 ggcaatactt tcaattacgg cacgggcaat atgtgcaggg ttggtacctc ttgttaaacc
    10201 ggttaacatg cccctggctt cctgattcca atacggtgca cccagtcctg caaaagcagg
    10261 cactatatat acgccctctg tgttttttac ctgtacagcc aatgcttcaa tatcggcagt
    10321 atgcctaatc aggcccaacc catcacgcaa ccattgtacg gtagcgccgg ccataaatac
    10381 gcttccttcc aaagcatatg ctgttttacc attaatttgc caggcaatgg tggttaacag
    10441 gttgtgttgc gagagtacaa ttttttcgcc ggtttgcatg agcataaaac agccggtgcc
    10501 ataagtgttt tttaccatac ccggttcggt acacatttgc ccgaataagg ccgcctgctg
    10561 atcaccggca attgctgcaa cgggtgtggc tgcatgggtt aaaatggcat gtgttacccc
    10621 atatacttca ctgctgcttt ttacttgtgg cagtatttgt gggggtatat tcatgagttg
    10681 caataaatca tcatcccatt gcagggtatg aatattgaac aacatggtac gtgatgcatt
    10741 gcttacatcg gtagcaaata ccttaccgtt ggttagcttc cacaacaacc aggcatcaat
    10801 ggtgccaaaa cacaaatggc cattttctgc a
//
