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Overview
1.1
1.2

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP085096.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1 | arylpolyene | 630,862 | 674,563 | APE Ec | Other | 26%
Region 2 | thiopeptide | 1,442,608 | 1,467,627 |

NZ_CP085096.1 - Region 1 - arylpolyene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 630,862 - 674,563 nt. (total: 43,702 nt) Show pHMM detection rules used
arylpolyene: (APE_KS1 or APE_KS2)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | arylpolyene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002008.1 |  | 0.25 | Other | aryl polyenes | Xenorhabdus doucetiae
BGC0000837.1 |  | 0.24 | Other | APE Vf | Aliivibrio fischeri ES114
BGC0000836.1 |  | 0.24 | Other | APE Ec | Escherichia coli CFT073
BGC0001197.1 |  | 0.23 | Polyketide | frankiamicin | Frankia sp. EAN1pec
BGC0000234.1 |  | 0.22 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000886.1 |  | 0.21 | Other | allylmalonyl-CoA | Streptomyces tsukubensis
BGC0001895.1 |  | 0.20 | Polyketide | huanglongmycin A, huanglongmycin B, huanglongmycin C | Streptomyces sp. CB09001
BGC0001591.1 |  | 0.20 | Other | fatty acid enol ester | uncultured bacterium CSLC2
BGC0001688.1 |  | 0.20 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSLC2
BGC0001343.1 |  | 0.20 | Polyketide | aurachin A, aurachin D | Stigmatella aurantiaca Sg a15

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002008.1 |  | 0.59 | Other | aryl polyenes | Xenorhabdus doucetiae
BGC0000837.1 |  | 0.57 | Other | APE Vf | Aliivibrio fischeri ES114
BGC0000836.1 |  | 0.57 | Other | APE Ec | Escherichia coli CFT073
BGC0001197.1 |  | 0.56 | Polyketide | frankiamicin | Frankia sp. EAN1pec
BGC0000234.1 |  | 0.56 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000886.1 |  | 0.54 | Other | allylmalonyl-CoA | Streptomyces tsukubensis
BGC0001895.1 |  | 0.53 | Polyketide | huanglongmycin A, huanglongmycin B, huanglongmycin C | Streptomyces sp. CB09001
BGC0001591.1 |  | 0.52 | Other | fatty acid enol ester | uncultured bacterium CSLC2
BGC0001688.1 |  | 0.52 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSLC2
BGC0001343.1 |  | 0.52 | Polyketide | aurachin A, aurachin D | Stigmatella aurantiaca Sg a15

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP085096.1 - Region 2 - thiopeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,442,608 - 1,467,627 nt. (total: 25,020 nt) Show pHMM detection rules used
thiopeptide: ((YcaO or TIGR03882) and ((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or PF07366 or PF06968 or PF04055) or thiostrepton)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Thiopeptides
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | thiopeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001238.1 |  | 0.18 | Other | biotin | Aspergillus nidulans
BGC0001239.1 |  | 0.18 | Other | biotin | Aspergillus nidulans
BGC0000554.1 |  | 0.17 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000518.1 |  | 0.17 | RiPP | informatipeptin | Streptomyces viridochromogenes DSM 40736
BGC0000551.1 |  | 0.16 | RiPP | SapB | Streptomyces coelicolor A3(2)
BGC0001526.1 |  | 0.16 | Other | bartolosides E, bartolosides F, bartolosides G, bartolosides H, bartolosides I, bartolosides J, bartolosides K | Synechocystis salina LEGE 06099
BGC0001120.1 |  | 0.16 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0000519.1 |  | 0.16 | RiPP | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0000504.1 |  | 0.16 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0001551.1 |  | 0.16 | RiPP | citrulassin E | Streptomyces glaucescens

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001238.1 |  | 0.49 | Other | biotin | Aspergillus nidulans
BGC0001239.1 |  | 0.49 | Other | biotin | Aspergillus nidulans
BGC0000554.1 |  | 0.48 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000518.1 |  | 0.48 | RiPP | informatipeptin | Streptomyces viridochromogenes DSM 40736
BGC0000551.1 |  | 0.47 | RiPP | SapB | Streptomyces coelicolor A3(2)
BGC0001526.1 |  | 0.47 | Other | bartolosides E, bartolosides F, bartolosides G, bartolosides H, bartolosides I, bartolosides J, bartolosides K | Synechocystis salina LEGE 06099
BGC0001120.1 |  | 0.47 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0000519.1 |  | 0.47 | RiPP | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0000504.1 |  | 0.47 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0001551.1 |  | 0.47 | RiPP | citrulassin E | Streptomyces glaucescens

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Thiopeptide predictions
Lists the possible core peptides for each biosynthetic enzyme, including the predicted class. Each core peptide shows the leader and core peptide sequences, separated by a dash. Predicted tail sequences are also shown.
No core peptides found.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
Thiopeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists its possible molecular weights and the scores for cleavage site prediction and RODEO. If relevant, other features, such as macrocycle and amidation, will also be listed.
No core peptides found.