LOCUS       c00001_NZ_BOJU..       12163 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_BOJU01000001.1 Fructobacillus tropaeoli strain RD012353 Contig01,
            whole genome shotgun sequence.
ACCESSION   NZ_BOJU01000001
VERSION     NZ_BOJU01000001
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 14:28:04
            Original ID  :: NZ_BOJU01000001.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 66113
            Orig. end    :: 78276
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12163
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[71113:73276](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..7163
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..12163
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12163
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(115..612)
                     /locus_tag="ctg1_56"
                     /transl_table=11
                     /translation="MKRIETFFYRLMHIIAVVAVVLISVLTFKSYQAVTAGDFSETPNV
                     SSSDIIQSSSKNRILIVFYKPGTQLEKSAKKVMDNQVGSQIGTNSIKVVYLNQFSDQTK
                     KIEKNFELKVHSNFYIVPVYQGNVGIQISGMNLNQLNQFIVSNNDVDSSNLKSILTTNW
                     GQ"
     CDS             complement(609..962)
                     /locus_tag="ctg1_57"
                     /transl_table=11
                     /translation="MKTKKEYLRFTFLTGNGLEHQSDGKTIEHYGLIPESLSSFKIPKM
                     SLIAVVEDDNQPIRFAVTTSNKMQKEISDKGQEKTDSFKIIFVPDQNDALMKTVIRIAL
                     TTGRVRPMPGELS"
     CDS             complement(952..1236)
                     /locus_tag="ctg1_58"
                     /transl_table=11
                     /translation="MVTKQLSLFKTKETMLTDRVEQVIKETIINCNTQTVKYKKQKKIR
                     QLQKYIDFLTIRLSFIPITSEQHAILKFKIDQETKNLNQLIMKEEENED"
     CDS             complement(1275..1496)
                     /locus_tag="ctg1_59"
                     /transl_table=11
                     /translation="MNNIDISIANYEKRKNAGLYYAAEVNGVNQKLVKQSSKAPKNLAL
                     QKNIKIRELKNAPLPYAKHMKWLAHPYY"
     CDS             complement(1518..1934)
                     /locus_tag="ctg1_60"
                     /transl_table=11
                     /translation="MSMNIAALRGRLVMKTELARTASGKTFTTGRIAVPRNFTNKDGER
                     PTDFFRFVLWGKQAQNFVELVDQGDRIGLDGHLQSSSYEKDGYTHFVTDIYVDHFDLIE
                     TRQDKEILRHQLAENELVSDGNDEVVVTDDDLPF"
     aSDomain        complement(1578..1931)
                     /aSDomain="TIGR00621"
                     /aSTool="tigrfam"
                     /description="ssb: single-stranded DNA-binding protein"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_60_0001"
                     /evalue="6.30E-18"
                     /identifier="TIGR00621"
                     /label="ctg1_60"
                     /locus_tag="ctg1_60"
                     /protein_end="119"
                     /protein_start="1"
                     /score="63.6"
                     /tool="antismash"
                     /translation="SMNIAALRGRLVMKTELARTASGKTFTTGRIAVPRNFTNKDGERP
                     TDFFRFVLWGKQAQNFVELVDQGDRIGLDGHLQSSSYEKDGYTHFVTDIYVDHFDLIET
                     RQDKEILRHQLAEN"
     PFAM_domain     complement(1629..1928)
                     /aSDomain="SSB"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00436.27"
                     /description="Single-strand binding protein family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_60_0001"
                     /evalue="3.10E-18"
                     /label="ctg1_60"
                     /locus_tag="ctg1_60"
                     /protein_end="102"
                     /protein_start="2"
                     /score="65.8"
                     /tool="antismash"
                     /translation="MNIAALRGRLVMKTELARTASGKTFTTGRIAVPRNFTNKDGERPT
                     DFFRFVLWGKQAQNFVELVDQGDRIGLDGHLQSSSYEKDGYTHFVTDIYVDHFDL"
     CDS             complement(1956..2822)
                     /locus_tag="ctg1_61"
                     /transl_table=11
                     /translation="MQRINLQQIQSFEQFYRIPKIFFTSEKYKDMRLESKTAYAILRDR
                     FELSLKNGWVDEQQNVYFVFTVAALQEILGCGKNKVIAIKKDLAKYGLLEEEKMGFNRA
                     NRLYIGAVTNDSFSENSLEPLGDKEVSKSNLRKFEKQTTGGLKNKPPKVSKSNPNDTDY
                     SDTELSDTKPNEKRDDDDDVLTQSAESESQKEKLLIDQYRKETGGSITQVKIQRLSELA
                     KYHGPLIVSEAITKAALNDSSNLFYIEQVIDTLEQEKQQWQKTLSEQSTQSKEIAPKVP
                     MFRFDKL"
     PFAM_domain     complement(2559..2783)
                     /aSDomain="RepA_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF06970.13"
                     /description="Replication initiator protein A (RepA)
                     N-terminus"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_61_0002"
                     /evalue="1.50E-28"
                     /label="ctg1_61"
                     /locus_tag="ctg1_61"
                     /protein_end="88"
                     /protein_start="13"
                     /score="98.6"
                     /tool="antismash"
                     /translation="QFYRIPKIFFTSEKYKDMRLESKTAYAILRDRFELSLKNGWVDEQ
                     QNVYFVFTVAALQEILGCGKNKVIAIKKDL"
     CDS             complement(2809..3066)
                     /locus_tag="ctg1_62"
                     /transl_table=11
                     /translation="MNNNTGLDLRQIIKGYRVSHSMTQKNLADSWQVPQRAISRWEQSA
                     QSNPSIESLLHISSGLNLSIDELIEQTFVNEEEDTSNAKN"
     PFAM_domain     complement(2863..3030)
                     /aSDomain="HTH_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01381.24"
                     /description="Helix-turn-helix"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_62_0003"
                     /evalue="3.20E-09"
                     /label="ctg1_62"
                     /locus_tag="ctg1_62"
                     /protein_end="68"
                     /protein_start="12"
                     /score="36.8"
                     /tool="antismash"
                     /translation="IKGYRVSHSMTQKNLADSWQVPQRAISRWEQSAQSNPSIESLLHI
                     SSGLNLSIDEL"
     CDS             3556..4218
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_63"
                     /sec_met_domain="Abi (E-value: 7.4e-16, bitscore: 53.1,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIIKKIFVLILLIAIVLVAGYISGSSYSLLSQSISVALYIFSIS
                     IAVFIVKAITKVKIFEKLNWYDVRIIIQNYILQMALLYLIRLISTKLEITTNYKNQENI
                     LQILQGLSAPILSIMLSFIILFGPILEEIVFRGYVMNIFERKKMGIFSVILSSLIFSYL
                     HLHSFLITENNIIAFLSYFITGISLALTYRKTKKLTASIAQHMLANVIASIPIMIMI"
     PFAM_domain     3907..4185
                     /aSDomain="Rce1-like"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02517.18"
                     /description="Type II CAAX prenyl endopeptidase Rce1-like"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_63_0004"
                     /evalue="3.20E-14"
                     /label="ctg1_63"
                     /locus_tag="ctg1_63"
                     /protein_end="210"
                     /protein_start="117"
                     /score="53.1"
                     /tool="antismash"
                     /translation="IMLSFIILFGPILEEIVFRGYVMNIFERKKMGIFSVILSSLIFSY
                     LHLHSFLITENNIIAFLSYFITGISLALTYRKTKKLTASIAQHMLANV"
     CDS             complement(4514..4681)
                     /locus_tag="ctg1_64"
                     /transl_table=11
                     /translation="MMNNINSLNFIDEDELSCINGGVVLTDGGGAYFSNATTGSDGGAF
                     GLWDWMTYGR"
     CDS             5001..7163
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 331.5; E-value:
                     1.6e-100)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_65"
                     /sec_met_domain="TIGR01193 (E-value: 4.2e-289, bitscore:
                     955.6, seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_C39 (E-value: 7.2e-44, bitscore:
                     143.6, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKFKYISQVDERDCGTACLAMVSKTYGHNISIARLRNLAKTNLEG
                     STALGLKKAAEKINFDVKAIRADMSLFNNPKQLPFPFIVHIQKPDHGQLLEHYYVVYKA
                     TKNTIKIADPDPDVKKTSMTYEEFSHQWTGVALFFAPNPEFKPELESTNSLSGLSTVIF
                     KQKGLVANIVAASLFVTLVSIVGSYFIQLLVDEYVPNNMMGTLSIVSLGLISAYIFQQI
                     MTYVQQYLLIILGQRLSIDIILSYIKHLFKLPMNFFYTRRVGKLTSRFNDANSVIEAVA
                     SSILSMLIDVVIVIIMAIVLLSYNANLFLITALSIPVYSLIVLAFVKTFSRLNHETMRS
                     GADLEASVIERLNGMETIKALGAEATGYEEIDQNYVRFLENSFAKARMTAIQEALKGTL
                     KLLFQVIVLWYGANLVVQGRLTIGELMAYNALLGYFTEPLQSIINLQSKIQSAIVAAHR
                     LREIYAVTSEFKDEEKRLVIDSHHLTVQFKDVSFEYQYNQPIFNHLKLTIHNNEKIALV
                     GTSGSGKSTLVKLLVRFFELEDNHGEITINGHDIRHFKKESLRTTITYVPQEPHLFTGT
                     IIDNLMLGVKKPITNEAIFKATEIAGIREDIEKMSQGFNTEITDSGMLSGGQRQRLSLA
                     RALLTDSKILILDESTSNLDILTEKKVIDNLLALTDKTIIFVAHRLTIAERVNRLVMLE
                     NGKIVADGKHSDLIGKNEAYTNLVQK"
     PFAM_domain     5004..5429
                     /aSDomain="Peptidase_C39"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03412.17"
                     /description="Peptidase C39 family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_65_0005"
                     /evalue="3.30E-42"
                     /label="ctg1_65"
                     /locus_tag="ctg1_65"
                     /protein_end="143"
                     /protein_start="1"
                     /score="143.6"
                     /tool="antismash"
                     /translation="KFKYISQVDERDCGTACLAMVSKTYGHNISIARLRNLAKTNLEGS
                     TALGLKKAAEKINFDVKAIRADMSLFNNPKQLPFPFIVHIQKPDHGQLLEHYYVVYKAT
                     KNTIKIADPDPDVKKTSMTYEEFSHQWTGVALFFAPNP"
     aSDomain        5022..7157
                     /aSDomain="TIGR01193"
                     /aSTool="tigrfam"
                     /description="bacteriocin_ABC: ABC-type bacteriocin
                     transporter"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_65_0002"
                     /evalue="4.50E-288"
                     /identifier="TIGR01193"
                     /label="ctg1_65"
                     /locus_tag="ctg1_65"
                     /protein_end="719"
                     /protein_start="7"
                     /score="955.6"
                     /tool="antismash"
                     /translation="QVDERDCGTACLAMVSKTYGHNISIARLRNLAKTNLEGSTALGLK
                     KAAEKINFDVKAIRADMSLFNNPKQLPFPFIVHIQKPDHGQLLEHYYVVYKATKNTIKI
                     ADPDPDVKKTSMTYEEFSHQWTGVALFFAPNPEFKPELESTNSLSGLSTVIFKQKGLVA
                     NIVAASLFVTLVSIVGSYFIQLLVDEYVPNNMMGTLSIVSLGLISAYIFQQIMTYVQQY
                     LLIILGQRLSIDIILSYIKHLFKLPMNFFYTRRVGKLTSRFNDANSVIEAVASSILSML
                     IDVVIVIIMAIVLLSYNANLFLITALSIPVYSLIVLAFVKTFSRLNHETMRSGADLEAS
                     VIERLNGMETIKALGAEATGYEEIDQNYVRFLENSFAKARMTAIQEALKGTLKLLFQVI
                     VLWYGANLVVQGRLTIGELMAYNALLGYFTEPLQSIINLQSKIQSAIVAAHRLREIYAV
                     TSEFKDEEKRLVIDSHHLTVQFKDVSFEYQYNQPIFNHLKLTIHNNEKIALVGTSGSGK
                     STLVKLLVRFFELEDNHGEITINGHDIRHFKKESLRTTITYVPQEPHLFTGTIIDNLML
                     GVKKPITNEAIFKATEIAGIREDIEKMSQGFNTEITDSGMLSGGQRQRLSLARALLTDS
                     KILILDESTSNLDILTEKKVIDNLLALTDKTIIFVAHRLTIAERVNRLVMLENGKIVAD
                     GKHSDLIGKNEAYTNLVQ"
     PFAM_domain     5514..6317
                     /aSDomain="ABC_membrane"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00664.25"
                     /description="ABC transporter transmembrane region"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_65_0006"
                     /evalue="8.70E-53"
                     /label="ctg1_65"
                     /locus_tag="ctg1_65"
                     /protein_end="439"
                     /protein_start="171"
                     /score="179.8"
                     /tool="antismash"
                     /translation="IVAASLFVTLVSIVGSYFIQLLVDEYVPNNMMGTLSIVSLGLISA
                     YIFQQIMTYVQQYLLIILGQRLSIDIILSYIKHLFKLPMNFFYTRRVGKLTSRFNDANS
                     VIEAVASSILSMLIDVVIVIIMAIVLLSYNANLFLITALSIPVYSLIVLAFVKTFSRLN
                     HETMRSGADLEASVIERLNGMETIKALGAEATGYEEIDQNYVRFLENSFAKARMTAIQE
                     ALKGTLKLLFQVIVLWYGANLVVQGRLTIGELMAYNALLGYFTEPL"
     PFAM_domain     6504..6956
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_65_0007"
                     /evalue="4.00E-30"
                     /label="ctg1_65"
                     /locus_tag="ctg1_65"
                     /protein_end="652"
                     /protein_start="501"
                     /score="105.2"
                     /tool="antismash"
                     /translation="NHLKLTIHNNEKIALVGTSGSGKSTLVKLLVRFFELEDNHGEITI
                     NGHDIRHFKKESLRTTITYVPQEPHLFTGTIIDNLMLGVKKPITNEAIFKATEIAGIRE
                     DIEKMSQGFNTEITDSGMLSGGQRQRLSLARALLTDSKILILDESTS"
     CDS             7179..8000
                     /locus_tag="ctg1_66"
                     /transl_table=11
                     /translation="LINHNQLESAEFYQRRYGTFTTKLIWPIVMAIILIFVFLCFTKKE
                     ITVKSIGQIIPQTTLTTIQSANNSAIIENDLKENKVVHQGDTLIVFNDKDTSINQNNNQ
                     QKINRTNSRLQALNTYKQSVEQGKNLFTTNDEYGYSDQYTDYQSQLDDINLSNQENIDD
                     VNQSDTEQKNKDKKISQSNQSANQKKQSLKSKTLTSINQEIQNLNDSQIDLKSNQESLT
                     NTANHAMIKSPTDGVIHLRDATEKSQYLPSGTHLSCFDQSNKACSKLYSSC"
     CDS             8005..8274
                     /locus_tag="ctg1_67"
                     /transl_table=11
                     /translation="MNNLKDDQKIRFQANQTGPKPFLLNGVIEHIDDAPIETKQGNVYL
                     IRAKMALKNADYDQIRYGLEGKVSVITGKKTWINYIKSLIFNNE"
     CDS             complement(8707..9129)
                     /locus_tag="ctg1_68"
                     /transl_table=11
                     /translation="LFTNDPSRKTISENTKKVILKLEKENPNSSPTVVTAGNVRPTAFG
                     LKSTVRDEVLYPDMSNLFSGFTAEQISNMKAPKDVMIGVNKGWTGESADTNHVDSGSAI
                     GDLNDDEYLIHDFTALYYVNGFDNSNTFIFKQDNNS"
     CDS             complement(9350..10099)
                     /locus_tag="ctg1_69"
                     /transl_table=11
                     /translation="MAGGAKGQGSFMGRMAAPGVALGALAGAGATKLNEQRKIRQERAR
                     QNDQPKENPDKPVVDHRKQDQESAEKLSKADTPEESNTDSNRSAGGEDKGQSADAGNSS
                     NTANDKRGQEAADKLSQDPDSENQSSSNGQLPSDTQSNENDRSSKLNGDNKGQETAEKL
                     SSFNGSSEGTEDGTGGNQNNESTSSTPSTQQRLEQMERQQRQSEERVQRIRQKAAQRQA
                     QLKQRRQRAMQQLAQDSKDPHQSAHQK"
     CDS             complement(10559..10873)
                     /locus_tag="ctg1_70"
                     /transl_table=11
                     /translation="MRIDTSEYPTGENAVPEKRVKQLKLLSKAATFTCIAMYVSYIPQI
                     ISNFSGHPVGVLQPLVAMINASFWAGYGWTKTYKDWPIIISNVPGVLFGLFTVITIYIH
                     "
     PFAM_domain     complement(10568..10801)
                     /aSDomain="MtN3_slv"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03083.18"
                     /description="Sugar efflux transporter for intercellular
                     exchange"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_70_0008"
                     /evalue="6.90E-06"
                     /label="ctg1_70"
                     /locus_tag="ctg1_70"
                     /protein_end="102"
                     /protein_start="24"
                     /score="26.1"
                     /tool="antismash"
                     /translation="LLSKAATFTCIAMYVSYIPQIISNFSGHPVGVLQPLVAMINASFW
                     AGYGWTKTYKDWPIIISNVPGVLFGLFTVITIY"
     CDS             11058..11558
                     /locus_tag="ctg1_71"
                     /transl_table=11
                     /translation="MNKSEVFEYLQQKNVWHEITEHQALFSMDSIVDVDLPYPDADAKN
                     LFVRDDKKRNYYLITVKGDKRVDLKAFRKENQTRPLSFASEEDLLRLMGLIPGSVSPFG
                     LLNDEDRQVNFFLDEEFLKEPGLIGIHPNENTATVWLKTLNLLEMIQEHGNEVTTVPIP
                     ERE"
     PFAM_domain     11184..11495
                     /aSDomain="tRNA_edit"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04073.17"
                     /description="Aminoacyl-tRNA editing domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_71_0009"
                     /evalue="1.40E-25"
                     /label="ctg1_71"
                     /locus_tag="ctg1_71"
                     /protein_end="146"
                     /protein_start="42"
                     /score="89.8"
                     /tool="antismash"
                     /translation="AKNLFVRDDKKRNYYLITVKGDKRVDLKAFRKENQTRPLSFASEE
                     DLLRLMGLIPGSVSPFGLLNDEDRQVNFFLDEEFLKEPGLIGIHPNENTATVWLKTLNL
                     "
ORIGIN
        1 gaatgcaatc aaggaaaatg tcacaacggc atataatctt tgacgaagaa taatcttatc
       61 ttcaagaaaa aattgccatt gccctggtgc taaatgaaat ttcttaaaca tctcttactg
      121 cccccaattc gtagttaaaa tacttttcaa attagaacta tcaacgtcat tatttgagac
      181 gataaattga tttaactgat ttagattcat accagaaatt tgaataccta cattgccttg
      241 atagacgggt acaatataaa aatttgaatg aactttaagt tcaaaattct tttcaatttt
      301 tttagtttgg tcagaaaact gattcaaata aacaacttta atactatttg tgccaatctg
      361 agaaccgact tggttgtcca tcactttttt agcagatttt tcaagttggg ttcctggttt
      421 ataaaaaaca atcaaaattc gatttttact tgaagactga atgatatccg aagaagaaac
      481 gttgggcgtt tctgaaaaat caccggctgt cactgcttga taagatttaa aagttaaaac
      541 actaattaac acaacggcca ctactgcaat aatgtgcata agtctgtaga aaaaggtttc
      601 aattcgcttc atgataattc acctggcatt ggccgcactc gaccagttgt taaagcaatt
      661 cgtatgactg ttttcatcaa ggcatcattt tgatcaggaa caaaaatgat tttaaaagaa
      721 tcagtttttt cttgtccctt atcactaatt tctttctgca ttttgttact tgtagttacg
      781 gcaaaccgta ttggctgatt gtcatcttca accacggcaa tcaaactcat tttaggaatt
      841 ttgaacgaag acagactctc aggtattaag ccataatgct caatggtttt gccatctgac
      901 tgatgttcca atccatttcc tgttaaaaaa gtaaaacgta aatattcttt tttagtcttc
      961 attttcttcc tccttcatga ttaattgatt gaggtttttg gtttcttgat caatcttaaa
     1021 tttcaatatt gcatgttgct cactcgtgat tgggatgaag cttaatctga tagtcaagaa
     1081 atcaatatat ttttgtaatt gacgaatttt cttttgcttt ttatatttaa ctgtttgtgt
     1141 gttgcaatta ataattgttt cttttatcac ctgctcaaca cggtcagtta gcattgtttc
     1201 tttagtttta aataagctca actgtttagt aaccattaca cttctccctc cctagtctct
     1261 ctgaaatgta ttaattaata atatggatgg gctaaccatt tcatatgttt tgcgtatggc
     1321 aatggggcat tttttaattc tctaatctta atgtttttct gcagcgctaa attttttgga
     1381 gctttactac tttgtttaac tagcttctga ttcactccgt ttacttcggc cgcataatac
     1441 aaaccagcat tttttctttt ttcataatta gcaatagaaa tatcaatgtt attcatactt
     1501 ttatctcctt tccaaaacta aaagggcaaa tcatcatcgg ttacaacaac ctcatcattg
     1561 ccgtcagaaa ctaattcatt ttctgctaac tggtggcgaa ggatttcttt atcttgacga
     1621 gtttcaatca aatcaaaatg gtctacataa atgtcagtta caaaatgggt atagccatct
     1681 ttttcgtatg aactactttg aagatgacca tctaaaccaa tacgatcacc ttgatcaacc
     1741 aattcaacaa aattctgtgc ttgtttcccc cagagaacaa agcggaagaa gtcggttggc
     1801 cgttctccat ccttattcgt aaaatttctt ggtacggcaa tccgaccggt tgtaaaagtt
     1861 ttaccagaag ccgtgcgggc caactcggtt ttcataacta aacgaccacg taatgctgca
     1921 atattcatac tcataatttt tgtcctcctg ttgttttaca acttgtcaaa acgaaacatt
     1981 ggcactttag gtgctatttc ttttgattga gtagactgtt cacttaatgt tttctgccat
     2041 tgttgctttt cttgttctag cgtgtcgata acttgttcaa tataaaaaag atttgacgaa
     2101 tcatttagcg ctgctttcgt gatggcttca ctaacaatta agggaccatg atactttgct
     2161 aattctgaca accgttgtat tttcacttga gtaattgatc cacctgtctc ttttcgatat
     2221 tgatcaatca gcaatttttc cttttgcgat tccgattctg cagattgagt taatacgtca
     2281 tcatcatcat ctcgtttttc atttggctta gtatcactta attcagtatc actatagtca
     2341 gtatcattag ggtttgattt tgaaaccttt ggaggtttat ttttcaaacc tccagtggtt
     2401 tgcttttcaa acttccggag gtttgatttt gaaacctcct tgtctcccaa gggttcaagg
     2461 gagttttctg agaaagaatc atttgttact gcgccaatat aaagacgatt tgcacgattg
     2521 aaacccattt tttcttcttc gagcaaccca tatttagcta agtctttttt aatggcaatc
     2581 actttgtttt tgccacagcc taaaatttct tgcaaagctg caaccgtgaa aacaaagtaa
     2641 acattttgct gctcatcaac ccagccgttt tttaaggaca attcaaaccg gtctcttaaa
     2701 atggcatagg ctgtcttgga ttccaatctc atatctttat atttttctga agtaaaaaag
     2761 atttttggaa ttcgataaaa ttgttcaaat gactgaattt gttggaggtt aattctttgc
     2821 atttgatgtg tcctcctctt cattaacaaa agtctgttca atcaattcat caattgatag
     2881 atttaaacca gaagagatat gcaacaatga ctcaattgaa ggatttgatt gggcggattg
     2941 ttcccatctt gaaatcgcac gttgtggtac ttgccaagaa tcggccaaat ttttctgagt
     3001 catggaatga ctaactcgat accccttaat aatttgccgc aaatctaaac ctgtattgtt
     3061 attcatgtta tactcctact atgtgtaaag gcccttggtg accaccaact aaaaaaagta
     3121 aaaaaaaaga agccacatcg ggcttctttg gtttgcatat atgcaaaaaa atataagagt
     3181 tattggcaat gaaatcattg ctgccactca ctaaattcgc cttctgttgc ttttaataat
     3241 gcgctttggg gtaaatgaac taaggcattt gtcaagtctt aatgcaacag tttaaaattt
     3301 ttctttgaaa taacctcttt aaagctgatt attcttattt ttctgataaa atgaacacat
     3361 cattttttgt agatcctaac agaaatacaa gatctaatta atgaaattag aaacataaaa
     3421 agtgaaatta gtaaaaccag cggcactgtt ataaacaaaa gaaaattaaa ataactagta
     3481 aaaataattt gatataataa ctaaccaaag tgggattttt aaaagattat gattatgtat
     3541 aaggaaagaa agtcaatgaa gataataaaa aagatttttg ttctgatatt gttaattgct
     3601 atagttttag tagcaggata tatttcggga tcatcctatt ctcttttgtc gcagtcaatt
     3661 agtgtagcat tatatatttt cagtatcagt attgctgttt ttattgtcaa agcgattaca
     3721 aaagtaaaaa tatttgaaaa gttgaactgg tatgacgttc gaataattat acaaaattat
     3781 atactacaaa tggcccttct atatttgata cgtttaatta gtacaaaatt agaaatcaca
     3841 actaattata agaaccaaga aaacatttta cagatactac aaggattatc agcaccaata
     3901 ttatcaatta tgttgtcatt tataatattg tttggcccga ttttagagga aatagttttt
     3961 agagggtatg ttatgaacat atttgaacgt aaaaaaatgg gtatttttag cgttatacta
     4021 tcatctttaa tattctctta tcttcattta cactctttct taataaccga gaataatatt
     4081 attgcatttt tgtcttattt tataactgga atatccttag ctttaactta tcgaaaaact
     4141 aaaaaattaa cagcaagcat tgctcaacat atgcttgcaa acgtaattgc atcaatacct
     4201 attatgataa tgatttaggt atgtcaaaaa tactatttct agcaaaaata aaagaaatcg
     4261 aatctcttaa tgggcttgac ttctggtaaa aaagcagtct taaatattat gatttaatgt
     4321 gaatcctaac ttaagatatg tcattgaccg actttaagga ctgataccgt ttgaatatcg
     4381 gttgtcagtc ctttataata gttgaaaaat cattgctgct ttgtcgtaaa tttactcata
     4441 ataaaagcct caaaattttg gagaaaattt tgaggctttt attatgagac tactttttta
     4501 attttatttt tgattaacgt ccgtacgtca tccaatccca caatccaaag gcaccaccat
     4561 cactaccagt ggtagcatta gaaaaataag cacctccgcc atcagtcaat acaactcctc
     4621 cattgataca agatagttca tcttcatcaa taaaattcaa agaattaata ttattcatca
     4681 ttctctttct ctccctcctt acaatgatat aaataaaatt tattgcccaa attttaccat
     4741 attattcata taaataatat atttatatag ataatttatg ggttttatct agatattata
     4801 tatgtttttt cacattatac tcttttaatc atcaaagtta attcattctt atatcaacgc
     4861 caaaagttgt tatattttag ttatcttctt caattatgat aaaattttgt gtgttcataa
     4921 acaataaggt tttatcatat ttttgttcaa catacattgc atctcaactt aattcatgct
     4981 aactaaggaa taaaataaat atgaaattca aatatatatc acaagtagac gaaagagact
     5041 gcgggactgc ctgcttagcc atggtttcaa agacttacgg acataatatc tccatcgcta
     5101 gactacgtaa tttagctaag acaaacttgg aagggtctac cgcattaggg ttaaaaaaag
     5161 ctgcggaaaa aatcaatttt gatgttaagg ccatccgagc tgatatgagc ctatttaata
     5221 acccaaagca actgccattt ccatttatcg ttcacataca aaaacctgac catggccaat
     5281 tattggaaca ctattatgtc gtctataagg caactaaaaa caccattaaa attgccgatc
     5341 ctgacccaga tgtaaaaaaa acatctatga cttatgagga atttagccac caatggactg
     5401 gcgttgccct cttttttgct ccaaaccctg aattcaaacc agaattagaa agtacaaata
     5461 gtctaagcgg actgtcaaca gtcattttca aacaaaaagg actagttgct aatatcgtag
     5521 cggcttcact ttttgtaact ttagttagta ttgtaggatc ttactttatt caactgttag
     5581 ttgacgaata cgttcccaat aacatgatgg gcaccctctc catcgtcagt ctaggattga
     5641 tttcagcata tatttttcaa cagataatga cctatgtaca acagtacttg ctcattattc
     5701 tcggacaacg gttgtcgatt gacatcattc tttcctacat caagcatctt ttcaagttgc
     5761 ctatgaattt tttctatact cgacgagtag ggaaattaac ttctcgtttt aatgacgcaa
     5821 attctgtcat tgaagcagtg gcttcatcaa ttctttccat gctcattgac gtagtcattg
     5881 tcattatcat ggcaattgtg ttactcagct ataatgctaa cttgttcttg atcacagccc
     5941 tatcaatccc agtatatagt ttaattgttt tagcctttgt taaaaccttt tcacgtctaa
     6001 atcacgagac catgcgctcg ggtgcagatc ttgaggcttc cgttattgag cgcttaaatg
     6061 gaatggaaac gattaaagca ttaggtgctg aagcaacagg ttacgaggaa atcgatcaaa
     6121 attatgttcg ttttttggaa aactcttttg ctaaagcacg catgactgcc attcaggagg
     6181 ccttaaaagg tactctaaaa ctcctttttc aagtaatcgt gttatggtac ggtgctaatt
     6241 tagttgttca gggacgttta acgattggag agttaatggc ttataacgct cttttaggtt
     6301 attttaccga acccttgcag tccattatta accttcaaag taagattcaa tctgccatcg
     6361 ttgctgccca tcggttaaga gaaatatatg ccgtgacatc tgaatttaaa gacgaggaaa
     6421 agcgcttagt cattgatagt catcatctaa cagtccagtt caaagatgtt tcttttgagt
     6481 atcaatataa tcaacctatc tttaatcatt taaagttaac cattcacaac aatgaaaaaa
     6541 ttgcgctggt tggtacttct ggttcaggta aatcaacgct tgtaaagctt cttgtacgct
     6601 tctttgagct agaggataat catggggaaa ttacgattaa tggccatgat attcgacact
     6661 ttaaaaaaga gtctcttcga acaacaatca cctatgtacc acaggaaccg catcttttta
     6721 caggtaccat tatcgataat ttaatgctag gtgttaaaaa gccaattacg aacgaagcga
     6781 tttttaaagc cactgaaatt gctgggattc gagaagatat tgaaaagatg tcacagggat
     6841 ttaatactga aattaccgat tcaggaatgc tttctggcgg tcagcgacag cgcctttcat
     6901 tagcacgagc actcctaacg gattccaaaa tacttattct tgatgaatca actagtaatc
     6961 tagatatact aactgaaaag aaagtaattg ataacttatt agctttaact gataaaacca
     7021 ttatttttgt ggcccaccgt ttgacaattg cagagcgtgt taatcgttta gttatgttgg
     7081 aaaatggaaa aatagtggca gatggcaaac attctgacct aattggaaaa aatgaagcct
     7141 acacaaatct agttcagaaa taaagtgagg gataaaattt gattaatcat aaccaattag
     7201 aaagtgccga gttttatcaa cgtcgctatg ggactttcac gactaaacta atttggccaa
     7261 ttgttatggc tattattctg atttttgtat ttttatgttt taccaagaaa gaaattacag
     7321 tcaaatcaat aggtcaaatt attccgcaaa caacattaac cacgattcag tcggccaaca
     7381 actcagccat tatagaaaat gacttgaaag aaaacaaagt cgttcatcaa ggtgacactt
     7441 taattgtgtt caatgataaa gatacgtcaa ttaatcagaa taacaatcaa caaaaaatta
     7501 atcgaacaaa tagtcgtttg caggctctta acacttataa acaaagtgtt gagcaaggaa
     7561 aaaatctttt tacgacgaat gacgaatatg gatactcaga ccaatatact gactatcaaa
     7621 gtcagttaga tgatattaat ttgtctaatc aggaaaacat tgatgacgtt aatcaaagcg
     7681 acactgaaca aaaaaataaa gacaaaaaaa ttagtcaaag taaccagtca gcaaatcaaa
     7741 aaaaacaatc actgaaatcg aaaactctca ctagtattaa ccaagaaatt caaaatctaa
     7801 atgatagtca aatcgactta aaaagcaacc aagaatcatt aacgaacaca gctaaccatg
     7861 caatgattaa atccccaacg gatggggtca tacatctaag agatgctact gaaaaatcgc
     7921 aatacttacc aagtggcaca catttatcct gttttgacca atcaaacaaa gcttgtagta
     7981 agctttacag ttcctgctaa ccagatgaac aacctgaaag atgatcaaaa aattcgtttt
     8041 caagctaatc aaacaggtcc caaaccattt ttgttaaatg gtgttattga gcacattgat
     8101 gacgcaccaa ttgaaacaaa acaaggaaat gtttacttaa ttcgagctaa aatggcccta
     8161 aagaatgcag attatgatca aattcggtat ggattagaag gtaaagtatc ggtgattact
     8221 ggtaaaaaga cttggattaa ctatattaag agtctcatat ttaacaatga atagaaaaaa
     8281 tgtcattttt gattttaatt tttattcgag ttaacaatta aaagttgctt ccctatatgt
     8341 ttatgctgct aaccaaacct ccgaaattgc gagatcctat tgtgtagctt gtccaacata
     8401 ataaccagta gcataggatg cgttattccg tccgcctatt gtttccttac ctaacataat
     8461 agctgttaac aaaagtaaaa aagaccagtc ccacattttc ggggctggtc tttcttttat
     8521 gataagcaca cttgctcaat tcgaccgaaa acaattggtc tagctctcat aatcccaatt
     8581 taatcacatg ttagttttgt gaaaaaagat aaatattaga aaataatgaa taagcatttt
     8641 ctatacaata tataaacaaa aaggaacagg ttaaaacctg ttcccttttt gtttatataa
     8701 gtttaattaa ctattattgt cttgcttaaa aatgaaagta ttgctattat caaacccatt
     8761 tacataataa agagcagtaa aatcatgaat tagatattcg tcatcattca gatcacctat
     8821 cgcagacccg ctatcaacat gattagtatc agctgattca ccggtccaac ctttatttac
     8881 accaatcatc acgtcttttg gtgctttcat atttgaaatt tgttcagcag tgaaaccact
     8941 gaataaatta ctcatatccg gataaagcac ttcatcacga acagtacttt ttaagccaaa
     9001 agcagttggc cgaacattac cagctgtcac cactgttggt gaagaattgg gattttcttt
     9061 ttcaagcttt aaaattactt ttttcgtgtt ttcactaatt gtttttcgac tagggtcatt
     9121 tgtaaacaaa acaataacat tattggtttt ggctgccttt tttacatcct cgatggtccc
     9181 aattttaaat tggtcctttt tccatgaatt gatgcttgat gaagaatagt cagttttttg
     9241 cgtgttcttc gtattgtgtt acatatagga agcgccgcca atcacaataa tgacagctcc
     9301 aagtacaatc cataatagat ttttcgtttt caacataact tatttccgct tatttttgat
     9361 gagccgactg atgtggatct tttgaatctt gtgccagttg ctgcatcgca cgttgtcttc
     9421 tctgtttcag ctgcgcttgc cgttgcgccg ctttttgacg aattcgttga actcgttctt
     9481 cactttgccg ttgctggcgt tccatttgtt ctagacgttg ctgagtggaa ggagtggaac
     9541 tggtactttc attattttga tttccaccag ttccatcttc agttccctca gaggaaccat
     9601 tgaaacttga taatttttcg gcagtttctt gtcccttgtt atcaccattt aacttggatg
     9661 atctgtcatt ttcattcgat tgagtatcag aaggcaattg gccattagac gatgattgat
     9721 tttctgaatc aggatcttga ctaagtttat cagcagcttc ttgaccgcgc ttatcatttg
     9781 ctgtgttgct tgagtttcca gcatcagcag attgaccctt atcttcgcca cccgctgatc
     9841 gattactgtc agtgttagat tcctcaggtg tatcagcctt ggataatttt tctgccgatt
     9901 cttgatcctg cttcctgtga tcgacgactg gcttatccgg attttccttt ggctgatcat
     9961 tttgccgagc acgttcttgg cgaatcttac gctgctcatt taatttagta gctccagcac
    10021 ctgctaatgc tcccaatgca actcccggtg ctgccatacg gcccataaac gaaccttgac
    10081 ccttagcacc gccagccatc ccaaatcaaa aaagaggaag aatttttaaa acagcatcaa
    10141 aatctatggc ggtggccgaa gccctttttt gcgctcaaaa atatcatttg agttaactta
    10201 tttataaccc agttactaag cggtgtcaag taaaaaagaa gcaatgaatc agaaaataaa
    10261 aaagcctgct gtgatcaaca acaggaccgt cttatttaaa aaaatgtcta aacccaataa
    10321 tgattttcac ataagctata tattggaaaa attagtaaga cgacgcttct tttttactcc
    10381 ctcaaatcct ttcaggatgt aatcattata atatagattt caaataaaag gtagaatttt
    10441 ctctactttt attgttcgtt atacactgat tggcctttat ttaccagttt tagtcagttt
    10501 cagttaaaga aagagaagcc cggtcaacac gaccgagctt ctttatttta tattgatatt
    10561 aatggatata aatcgttatc actgtgaaca agccaaacaa aactcccggg acgttcgaaa
    10621 taataattgg ccaatcttta tacgttttag tccagccata gccagcccag aacgatgcat
    10681 taatcatcgc tacgagtggc tgtaaaacac cgactggatg tcctgaaaaa ttgctaataa
    10741 tttgcggaat ataagaaaca tacatcgcaa tacatgtgaa tgtggcagct ttactgagga
    10801 gcttcagctg tttaacacgt ttttcaggga cagcgttttc acctgtagga tattctgaag
    10861 tatcaattct cataaaaatt tcctttctcc attgttcata cctcaaatta tagccgtttt
    10921 cagcatacat agcgagtaaa aatgaaacaa tgttgctttt tatgcaatat tcttagccgt
    10981 tattcaaaca attgcaatga ttaagcaact cttgctaatg atataatgtg acctatatta
    11041 aaaaccgagg taaaagcatg aataaaagtg aagtctttga gtatttgcag caaaaaaatg
    11101 tttggcacga aattaccgaa caccaagcgc tatttagtat ggatagcatt gttgatgttg
    11161 atttaccata ccctgacgcc gatgcaaaaa atctttttgt ccgtgatgat aagaaacgaa
    11221 attactatct gattaccgtt aagggagata aaagagttga cttgaaggcc ttccgcaagg
    11281 aaaatcagac tcgcccatta tcgtttgctt cagaagaaga tttgctaaga ttaatgggct
    11341 taattcctgg ctcggtttct ccctttggtc tcctgaacga tgaagaccgc caggtcaatt
    11401 ttttccttga tgaggaattt ttaaaagaac ccggactaat cgggattcac ccaaatgaaa
    11461 acacggcaac ggtctggctg aaaaccctta atctcctcga aatgattcaa gaacatggga
    11521 atgaagttac gactgtccct attcccgaac gagaataata tcatcataat ccacttaaaa
    11581 agctgcaaca ctgtttctgt aagtaaatat gaaccccgaa atttgtttgt ccaaatctcg
    11641 gcgttcatat cagcgctaca gcttttttag tatttcattc tttttttaag agacaacttg
    11701 atggtattgc tcctgggcaa tttgtacaat tggcatctgt tgtgaactgt acgtgcctaa
    11761 ttttttacca atatgttgga caagccaagc aggtaaataa ggtctggcaa ggagaactag
    11821 gtaagcatca aaacttagaa acgtttcgat atcctaaaat agctaaacaa ttcttcatcc
    11881 gcacgcacgg gttgacccag tcgcagcata ataatcgttt ccaaaacttg ttcatgacga
    11941 agcagatgtt ctttttgcgc taaacgaacc atgattcgtt tcaaaacccg ttgatcatca
    12001 acaaaccgat aagctttttc agcccaatca ataatggcaa aaccatcaaa gacattggct
    12061 tcaccaatgt ctgccaatgt taagcccata taacgcaata attgaatagc ggtactcaaa
    12121 tggatatctg tttgaccacg ttcaaacttt gaaatcacac tcg
//
