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Overview
1.1
1.2
1.3
1.4
1.5
1.6
1.7

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_AZUI01000001 (original name was: NZ_AZUI01000001.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1 | cyclic-lactone-autoinducer | 56,585 | 76,203 |
Region 2 | NRPS | 310,101 | 363,575 |
Region 3 | cyclic-lactone-autoinducer | 2,660,185 | 2,678,455 |
Region 4 | ranthipeptide | 2,788,252 | 2,809,974 |
Region 5 | cyclic-lactone-autoinducer | 3,424,625 | 3,444,480 |
Region 6 | cyclic-lactone-autoinducer | 5,141,127 | 5,161,693 |
Region 7 | RRE-containing | 5,941,052 | 5,961,342 |

c00001_NZ_AZUI.. - Region 1 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 56,585 - 76,203 nt. (total: 19,619 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001521.1 |  | 0.19 | NRP | auriculamide | Herpetosiphon aurantiacus DSM 785
BGC0000783.1 |  | 0.16 | Saccharide | O-antigen | Xanthomonas oryzae pv. oryzae
BGC0000774.1 |  | 0.15 | Saccharide | lipopolysaccharide | Xanthomonas campestris pv. campestris
BGC0000886.1 |  | 0.15 | Other | allylmalonyl-CoA | Streptomyces tsukubensis
BGC0001138.1 |  | 0.14 | Other (Nucleoside) | a201a | Marinactinospora thermotolerans
BGC0000815.1 |  | 0.13 | Alkaloid | loline | Epichloe uncinata
BGC0001312.1 |  | 0.09 | NRP | viscosin | Pseudomonas fluorescens SBW25
BGC0000457.1 |  | 0.08 | NRP | vicibactin | Rhizobium etli CFN 42
BGC0001190.1 |  | 0.08 | Polyketide | fusaric acid | Fusarium verticillioides 7600
BGC0000495.1 |  | 0.07 | RiPP | actagardine | Actinoplanes garbadinensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001521.1 |  | 0.51 | NRP | auriculamide | Herpetosiphon aurantiacus DSM 785
BGC0000783.1 |  | 0.47 | Saccharide | O-antigen | Xanthomonas oryzae pv. oryzae
BGC0000774.1 |  | 0.45 | Saccharide | lipopolysaccharide | Xanthomonas campestris pv. campestris
BGC0000886.1 |  | 0.45 | Other | allylmalonyl-CoA | Streptomyces tsukubensis
BGC0001138.1 |  | 0.43 | Other (Nucleoside) | a201a | Marinactinospora thermotolerans
BGC0000815.1 |  | 0.42 | Alkaloid | loline | Epichloe uncinata
BGC0001312.1 |  | 0.32 | NRP | viscosin | Pseudomonas fluorescens SBW25
BGC0000457.1 |  | 0.30 | NRP | vicibactin | Rhizobium etli CFN 42
BGC0001190.1 |  | 0.30 | Polyketide | fusaric acid | Fusarium verticillioides 7600
BGC0000495.1 |  | 0.28 | RiPP | actagardine | Actinoplanes garbadinensis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00001_NZ_AZUI.. - Region 2 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 310,101 - 363,575 nt. (total: 53,475 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000412.1 |  | 0.26 | NRP | pyochelin | Pseudomonas aeruginosa PAO1
BGC0000351.1 |  | 0.24 | NRP | exochelin | Mycolicibacterium smegmatis
BGC0000389.1 |  | 0.24 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0000343.1 |  | 0.24 | NRP | enterobactin | Pseudomonas sp. J465
BGC0000449.1 |  | 0.23 | NRP | tridecaptin | Paenibacillus terrae
BGC0001444.1 |  | 0.22 | Other | caboxamycin | Streptomyces sp. NTK 937
BGC0001538.1 |  | 0.22 | NRP, Polyketide | caboxamycin | Streptomyces sp. NTK 937
BGC0001636.1 |  | 0.22 | NRP | KK-1 | Curvularia clavata
BGC0001699.1 |  | 0.21 | Polyketide | nidulanin A | Aspergillus nidulans FGSC A4
BGC0000427.1 |  | 0.21 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000412.1 |  | 0.60 | NRP | pyochelin | Pseudomonas aeruginosa PAO1
BGC0000351.1 |  | 0.58 | NRP | exochelin | Mycolicibacterium smegmatis
BGC0000389.1 |  | 0.58 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0000343.1 |  | 0.57 | NRP | enterobactin | Pseudomonas sp. J465
BGC0000449.1 |  | 0.56 | NRP | tridecaptin | Paenibacillus terrae
BGC0001444.1 |  | 0.55 | Other | caboxamycin | Streptomyces sp. NTK 937
BGC0001538.1 |  | 0.55 | NRP, Polyketide | caboxamycin | Streptomyces sp. NTK 937
BGC0001636.1 |  | 0.55 | NRP | KK-1 | Curvularia clavata
BGC0001699.1 |  | 0.54 | Polyketide | nidulanin A | Aspergillus nidulans FGSC A4
BGC0000427.1 |  | 0.54 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 2, location 310100 - 363575:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (cys) + (cys - cys)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_306: cys - cys
  Search NORINE for peptide: strict or relaxed
  AMP-binding (557..952): cys
  NRPSPredictor2: cys
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      cys
    Small clusters prediction:
      cys
    Single AA prediction:
      cys
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLYNfSMIWK
    Nearest Stachelhaus code:
      cys
    Stachelhaus code match:
      90% (moderate)
  AMP-binding (1620..2015): cys
  NRPSPredictor2: cys
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      cys
    Small clusters prediction:
      cys
    Single AA prediction:
      cys
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLYNMSlIWK
    Nearest Stachelhaus code:
      cys
    Stachelhaus code match:
      90% (moderate)
ctg1_307: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (20..424): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophobic-aromatic
    Large clusters prediction:
      dhb, sal
    Small clusters prediction:
      dhb, sal
    Single AA prediction:
      dhb
  Stachelhaus prediction details:
    Stachelhaus sequence:
      aLagqgTtAK
    Nearest Stachelhaus code:
      ala
    Stachelhaus code match:
      40% (weak)
ctg1_309: cys
  Search NORINE for peptide: strict or relaxed
  AMP-binding (520..913): cys
  NRPSPredictor2: cys
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      cys
    Small clusters prediction:
      cys
    Single AA prediction:
      cys
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLYNLSLIWK
    Nearest Stachelhaus code:
      cys
    Stachelhaus code match:
      100% (strong)

c00001_NZ_AZUI.. - Region 3 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,660,185 - 2,678,455 nt. (total: 18,271 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001410.1 |  | 0.23 | Saccharide | polysaccharide A | Bacteroides fragilis
BGC0000488.1 |  | 0.23 | RiPP | circularin A | Clostridium beijerinckii
BGC0001291.1 |  | 0.23 | RiPP | enterocin NKR-5-3B | Enterococcus faecium
BGC0000767.1 |  | 0.22 | Saccharide | exopolysaccharide | Lactobacillus johnsonii
BGC0000765.1 |  | 0.22 | Saccharide | exopolysaccharide | Lactobacillus johnsonii
BGC0000766.1 |  | 0.22 | Saccharide | exopolysaccharide | Lactobacillus johnsonii
BGC0000803.1 |  | 0.21 | Saccharide | GG exopolysaccharide | Lactobacillus rhamnosus GG
BGC0000634.1 |  | 0.16 | Terpene | carotenoid | Brevundimonas sp. SD212
BGC0001391.1 |  | 0.16 | RiPP | thusin | Bacillus thuringiensis serovar rongseni
BGC0000568.1 |  | 0.16 | RiPP | microcin B17 | Escherichia coli

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001410.1 |  | 0.56 | Saccharide | polysaccharide A | Bacteroides fragilis
BGC0000488.1 |  | 0.56 | RiPP | circularin A | Clostridium beijerinckii
BGC0001291.1 |  | 0.56 | RiPP | enterocin NKR-5-3B | Enterococcus faecium
BGC0000767.1 |  | 0.55 | Saccharide | exopolysaccharide | Lactobacillus johnsonii
BGC0000765.1 |  | 0.55 | Saccharide | exopolysaccharide | Lactobacillus johnsonii
BGC0000766.1 |  | 0.55 | Saccharide | exopolysaccharide | Lactobacillus johnsonii
BGC0000803.1 |  | 0.54 | Saccharide | GG exopolysaccharide | Lactobacillus rhamnosus GG
BGC0000634.1 |  | 0.46 | Terpene | carotenoid | Brevundimonas sp. SD212
BGC0001391.1 |  | 0.46 | RiPP | thusin | Bacillus thuringiensis serovar rongseni
BGC0000568.1 |  | 0.46 | RiPP | microcin B17 | Escherichia coli

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00001_NZ_AZUI.. - Region 4 - ranthipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,788,252 - 2,809,974 nt. (total: 21,723 nt) Show pHMM detection rules used
ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or YcaO or TIGR03882)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | ranthipeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000804.1 |  | 0.14 | Saccharide | acarviostatin I03, acarviostatin II03, acarviostatin III03, acarviostatin IV03 | Streptomyces coelicoflavus ZG0656
BGC0001686.1 |  | 0.08 | NRP | N-octanoyl-Met-Phe-H | Clostridium sp. CAG:567
BGC0001553.1 |  | 0.06 | NRP, Polyketide | clifednamide A | Streptomyces sp. JV178
BGC0000344.1 |  | 0.06 | NRP | entolysin | Pseudomonas entomophila L48
BGC0001011.1 |  | 0.06 | NRP, Polyketide | meridamycin | Streptomyces sp. NRRL 30748
BGC0000388.1 |  | 0.05 | NRP | mannopeptimycin | Streptomyces hygroscopicus
BGC0000964.1 |  | 0.05 | NRP, Polyketide | burkholdac A | Burkholderia thailandensis E264
BGC0000163.1 |  | 0.05 | Polyketide | tetronasin | Streptomyces longisporoflavus
BGC0001598.1 |  | 0.04 | NRP, Polyketide | foxicins A-D | Streptomyces diastatochromogenes
BGC0000144.1 |  | 0.03 | Polyketide | salinomycin | Streptomyces albus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000804.1 |  | 0.44 | Saccharide | acarviostatin I03, acarviostatin II03, acarviostatin III03, acarviostatin IV03 | Streptomyces coelicoflavus ZG0656
BGC0001686.1 |  | 0.30 | NRP | N-octanoyl-Met-Phe-H | Clostridium sp. CAG:567
BGC0001553.1 |  | 0.26 | NRP, Polyketide | clifednamide A | Streptomyces sp. JV178
BGC0000344.1 |  | 0.25 | NRP | entolysin | Pseudomonas entomophila L48
BGC0001011.1 |  | 0.24 | NRP, Polyketide | meridamycin | Streptomyces sp. NRRL 30748
BGC0000388.1 |  | 0.22 | NRP | mannopeptimycin | Streptomyces hygroscopicus
BGC0000964.1 |  | 0.21 | NRP, Polyketide | burkholdac A | Burkholderia thailandensis E264
BGC0000163.1 |  | 0.21 | Polyketide | tetronasin | Streptomyces longisporoflavus
BGC0001598.1 |  | 0.19 | NRP, Polyketide | foxicins A-D | Streptomyces diastatochromogenes
BGC0000144.1 |  | 0.16 | Polyketide | salinomycin | Streptomyces albus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00001_NZ_AZUI.. - Region 5 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,424,625 - 3,444,480 nt. (total: 19,856 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000883.1 |  | 0.14 | Other | arginomycin | Streptomyces arginensis
BGC0001285.1 |  | 0.13 | Other (Fatty acid) | pseudopyronine A, pseudopyronine B | Pseudomonas putida
BGC0000528.1 |  | 0.12 | RiPP | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000043.1 |  | 0.11 | Polyketide | curacin A | Moorea producens 19L
BGC0001701.1 |  | 0.10 | RiPP | nisin O | Blautia obeum
BGC0000503.1 |  | 0.09 | RiPP | cinnamycin | Streptomyces cinnamoneus
BGC0001669.1 |  | 0.09 | RiPP | microvionin | Microbacterium arborescens
BGC0000310.1 |  | 0.09 | NRP | bacitracin | Bacillus licheniformis
BGC0000700.1 |  | 0.08 | Saccharide | istamycin | Streptomyces tenjimariensis
BGC0000845.1 |  | 0.08 | Other (Non-NRP beta-lactam) | clavulanic acid | Streptomyces clavuligerus ATCC 27064

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000883.1 |  | 0.43 | Other | arginomycin | Streptomyces arginensis
BGC0001285.1 |  | 0.41 | Other (Fatty acid) | pseudopyronine A, pseudopyronine B | Pseudomonas putida
BGC0000528.1 |  | 0.40 | RiPP | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000043.1 |  | 0.38 | Polyketide | curacin A | Moorea producens 19L
BGC0001701.1 |  | 0.35 | RiPP | nisin O | Blautia obeum
BGC0000503.1 |  | 0.33 | RiPP | cinnamycin | Streptomyces cinnamoneus
BGC0001669.1 |  | 0.33 | RiPP | microvionin | Microbacterium arborescens
BGC0000310.1 |  | 0.32 | NRP | bacitracin | Bacillus licheniformis
BGC0000700.1 |  | 0.32 | Saccharide | istamycin | Streptomyces tenjimariensis
BGC0000845.1 |  | 0.30 | Other (Non-NRP beta-lactam) | clavulanic acid | Streptomyces clavuligerus ATCC 27064

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00001_NZ_AZUI.. - Region 6 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
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Location: 5,141,127 - 5,161,693 nt. (total: 20,567 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000804.1 |  | 0.13 | Saccharide | acarviostatin I03, acarviostatin II03, acarviostatin III03, acarviostatin IV03 | Streptomyces coelicoflavus ZG0656
BGC0000540.1 |  | 0.12 | RiPP | paenibacillin | Paenibacillus polymyxa OSY-DF
BGC0001553.1 |  | 0.07 | NRP, Polyketide | clifednamide A | Streptomyces sp. JV178
BGC0000619.1 |  | 0.06 | RiPP | gassericin T | Lactobacillus gasseri
BGC0001602.1 |  | 0.06 | RiPP | gassericin-T | Lactobacillus gasseri
BGC0001388.1 |  | 0.06 | RiPP | gassericin E | Lactobacillus gasseri
BGC0000495.1 |  | 0.06 | RiPP | actagardine | Actinoplanes garbadinensis
BGC0001406.1 |  | 0.06 | NRP | telomycin | Streptomyces canus
BGC0000388.1 |  | 0.05 | NRP | mannopeptimycin | Streptomyces hygroscopicus
BGC0001598.1 |  | 0.04 | NRP, Polyketide | foxicins A-D | Streptomyces diastatochromogenes

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000804.1 |  | 0.42 | Saccharide | acarviostatin I03, acarviostatin II03, acarviostatin III03, acarviostatin IV03 | Streptomyces coelicoflavus ZG0656
BGC0000540.1 |  | 0.40 | RiPP | paenibacillin | Paenibacillus polymyxa OSY-DF
BGC0001553.1 |  | 0.29 | NRP, Polyketide | clifednamide A | Streptomyces sp. JV178
BGC0000619.1 |  | 0.26 | RiPP | gassericin T | Lactobacillus gasseri
BGC0001602.1 |  | 0.26 | RiPP | gassericin-T | Lactobacillus gasseri
BGC0001388.1 |  | 0.26 | RiPP | gassericin E | Lactobacillus gasseri
BGC0000495.1 |  | 0.26 | RiPP | actagardine | Actinoplanes garbadinensis
BGC0001406.1 |  | 0.24 | NRP | telomycin | Streptomyces canus
BGC0000388.1 |  | 0.21 | NRP | mannopeptimycin | Streptomyces hygroscopicus
BGC0001598.1 |  | 0.19 | NRP, Polyketide | foxicins A-D | Streptomyces diastatochromogenes

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
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Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
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c00001_NZ_AZUI.. - Region 7 - RRE-containing
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 5,941,052 - 5,961,342 nt. (total: 20,291 nt) Show pHMM detection rules used
RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RRE-containing | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000904.1 |  | 0.22 | Other | FR-900098 | Streptomyces rubellomurinus
BGC0001859.1 |  | 0.20 | Other (Phosphonate) | fosfomycin | Pseudomonas syringae
BGC0000928.1 |  | 0.16 | Other | T3 toxin | Cylindrospermopsis raciborskii T3
BGC0000188.1 |  | 0.16 | Alkaloid | saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2 | Cylindrospermopsis raciborskii T3
BGC0000550.1 |  | 0.15 | RiPP | salivaricin G32 | Streptococcus salivarius
BGC0000842.1 |  | 0.12 | Other (Non-NRP beta-lactam) | carbapenem MM4550 | Streptomyces argenteolus
BGC0000557.1 |  | 0.12 | RiPP | streptococcin A-FF22 | Streptococcus pyogenes
BGC0000043.1 |  | 0.12 | Polyketide | curacin A | Moorea producens 19L
BGC0000527.1 |  | 0.12 | RiPP | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0000559.1 |  | 0.11 | RiPP | subtilin | Bacillus subtilis subsp. spizizenii ATCC 6633

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000904.1 |  | 0.55 | Other | FR-900098 | Streptomyces rubellomurinus
BGC0001859.1 |  | 0.52 | Other (Phosphonate) | fosfomycin | Pseudomonas syringae
BGC0000928.1 |  | 0.47 | Other | T3 toxin | Cylindrospermopsis raciborskii T3
BGC0000188.1 |  | 0.47 | Alkaloid | saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2 | Cylindrospermopsis raciborskii T3
BGC0000550.1 |  | 0.45 | RiPP | salivaricin G32 | Streptococcus salivarius
BGC0000842.1 |  | 0.41 | Other (Non-NRP beta-lactam) | carbapenem MM4550 | Streptomyces argenteolus
BGC0000557.1 |  | 0.40 | RiPP | streptococcin A-FF22 | Streptococcus pyogenes
BGC0000043.1 |  | 0.39 | Polyketide | curacin A | Moorea producens 19L
BGC0000527.1 |  | 0.39 | RiPP | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0000559.1 |  | 0.38 | RiPP | subtilin | Bacillus subtilis subsp. spizizenii ATCC 6633

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names