LOCUS       NZ_GL732463.1          12154 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_GL732463.1 Streptococcus peroris ATCC 700780 SCAFFOLD1, whole
            genome shotgun sequence.
ACCESSION   NZ_GL732463
VERSION     NZ_GL732463.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 14:53:58
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 1278378
            Orig. end    :: 1290532
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12154
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[1283378:1285532](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..7154
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..12154
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12154
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="2"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             1182..2468
                     /locus_tag="ctg1_1279"
                     /transl_table=11
                     /translation="MKYRELAHKQVGGDKIDFKRVGTGIMFTYKMNVDVQEWDLFLQNH
                     PQGNLLQSSDWSKIKNTWGNERVGFYKDDQLVGVANILIQPLPLGLSMFYIPRGPVIDY
                     TDKELLKFVLLSLKKLAKKSRAIMVKFDPSLFISRTFIGQESVQDSRTLEIVEELQRNK
                     VHWTGLTKDMAENIQPRFQANIHKENFSLDQLSKSTRQAIRTAKNKGLEVKFGGLDLLD
                     EFSFLMKKTENRKNISLRGKDYYQKLLNTYPNHSFITMSYIDLPNRLEEVEQQLEKNLK
                     IAQKFTDKTKEGKIKENQQERKRLEEEVSFLKSCIDRGDSVVPLSATLTIEFGKASENL
                     YAGMNEEFRHYQPAIPTWFETAQHSFERGAETHNMGGIENSLEGGLFNFKSKFNPTIEE
                     FAGEFNYPTSSLYFLFNIAYKIRKKLRSR"
     PFAM_domain     1284..2441
                     /aSDomain="FemAB"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02388.18"
                     /description="FemAB family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1279_0063"
                     /evalue="1.30E-116"
                     /label="ctg1_1279"
                     /locus_tag="ctg1_1279"
                     /protein_end="420"
                     /protein_start="34"
                     /score="390.0"
                     /tool="antismash"
                     /translation="VQEWDLFLQNHPQGNLLQSSDWSKIKNTWGNERVGFYKDDQLVGV
                     ANILIQPLPLGLSMFYIPRGPVIDYTDKELLKFVLLSLKKLAKKSRAIMVKFDPSLFIS
                     RTFIGQESVQDSRTLEIVEELQRNKVHWTGLTKDMAENIQPRFQANIHKENFSLDQLSK
                     STRQAIRTAKNKGLEVKFGGLDLLDEFSFLMKKTENRKNISLRGKDYYQKLLNTYPNHS
                     FITMSYIDLPNRLEEVEQQLEKNLKIAQKFTDKTKEGKIKENQQERKRLEEEVSFLKSC
                     IDRGDSVVPLSATLTIEFGKASENLYAGMNEEFRHYQPAIPTWFETAQHSFERGAETHN
                     MGGIENSLEGGLFNFKSKFNPTIEEFAGEFNYPTSSLYFLFNIAYK"
     CDS             2745..3524
                     /locus_tag="ctg1_1280"
                     /transl_table=11
                     /translation="MAVISMKQLLEAGVHFGHQTRRWNPKMAKYIFTERNGIHVIDLQQ
                     TVKYADQAYDFMRDAAANDAVVLFVGTKKQAADAVAEEAVRSGQYFINHRWLGGTLTNW
                     GTIQKRIARLKEIKRMEEDGTFEVLPKKEVALLNKQRARLEKFLGGIEDMPRIPDVMYV
                     VDPHKEQIAVKEAKKLGIPVVAMVDTNTDPDDIDVIIPANDDAIRAVKLITAKLADAII
                     EGRQGEDATAVEAEFAASEAQADSIEEIVEVVEGDNA"
     aSDomain        2751..3422
                     /aSDomain="TIGR01011"
                     /aSTool="tigrfam"
                     /description="rpsB_bact: ribosomal protein uS2"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1280_0031"
                     /evalue="9.00E-105"
                     /identifier="TIGR01011"
                     /label="ctg1_1280"
                     /locus_tag="ctg1_1280"
                     /protein_end="226"
                     /protein_start="2"
                     /score="346.9"
                     /tool="antismash"
                     /translation="VISMKQLLEAGVHFGHQTRRWNPKMAKYIFTERNGIHVIDLQQTV
                     KYADQAYDFMRDAAANDAVVLFVGTKKQAADAVAEEAVRSGQYFINHRWLGGTLTNWGT
                     IQKRIARLKEIKRMEEDGTFEVLPKKEVALLNKQRARLEKFLGGIEDMPRIPDVMYVVD
                     PHKEQIAVKEAKKLGIPVVAMVDTNTDPDDIDVIIPANDDAIRAVKLITAKLADAIIEG
                     RQ"
     PFAM_domain     2769..3416
                     /aSDomain="Ribosomal_S2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00318.22"
                     /description="Ribosomal protein S2"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1280_0064"
                     /evalue="2.70E-95"
                     /label="ctg1_1280"
                     /locus_tag="ctg1_1280"
                     /protein_end="224"
                     /protein_start="8"
                     /score="317.8"
                     /tool="antismash"
                     /translation="LLEAGVHFGHQTRRWNPKMAKYIFTERNGIHVIDLQQTVKYADQA
                     YDFMRDAAANDAVVLFVGTKKQAADAVAEEAVRSGQYFINHRWLGGTLTNWGTIQKRIA
                     RLKEIKRMEEDGTFEVLPKKEVALLNKQRARLEKFLGGIEDMPRIPDVMYVVDPHKEQI
                     AVKEAKKLGIPVVAMVDTNTDPDDIDVIIPANDDAIRAVKLITAKLADAIIEG"
     aSDomain        3603..4622
                     /aSDomain="TIGR00116"
                     /aSTool="tigrfam"
                     /description="tsf: translation elongation factor Ts"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1281_0032"
                     /evalue="5.70E-95"
                     /identifier="TIGR00116"
                     /label="ctg1_1281"
                     /locus_tag="ctg1_1281"
                     /protein_end="340"
                     /protein_start="0"
                     /score="315.8"
                     /tool="antismash"
                     /translation="MAEITAKLVKELREKSGAGVMDAKKALVEVEGDIEKAIELLREKG
                     MAKAAKKADRVAAEGLTGVYVNGNVAAVVEVNAETDFVAKNAQFVELVNATAKVIAEGK
                     PANNEEALALTMPSGETLEAAYVSATATIGEKISFRRFALLEKTDAQHFGAYQHNGGRI
                     GVISVIEGGDEALAKQISMHIAAMKPTVLSYKELDAQFVKDELAQLNHVIDQDNESRAM
                     VGKPALPHLKFGSKAQLTDEVIAQAEADIKAELATEGKPEKIWDKIIPGKMDRFMLDNT
                     KVDQAYTLLAQVYIMDDSKTVEAYLESVNASVVEFARFEVGEGIEKASNDFEAEVAATM
                     "
     CDS             3603..4643
                     /locus_tag="ctg1_1281"
                     /transl_table=11
                     /translation="MAEITAKLVKELREKSGAGVMDAKKALVEVEGDIEKAIELLREKG
                     MAKAAKKADRVAAEGLTGVYVNGNVAAVVEVNAETDFVAKNAQFVELVNATAKVIAEGK
                     PANNEEALALTMPSGETLEAAYVSATATIGEKISFRRFALLEKTDAQHFGAYQHNGGRI
                     GVISVIEGGDEALAKQISMHIAAMKPTVLSYKELDAQFVKDELAQLNHVIDQDNESRAM
                     VGKPALPHLKFGSKAQLTDEVIAQAEADIKAELATEGKPEKIWDKIIPGKMDRFMLDNT
                     KVDQAYTLLAQVYIMDDSKTVEAYLESVNASVVEFARFEVGEGIEKASNDFEAEVAATM
                     AAALNN"
     PFAM_domain     3813..4571
                     /aSDomain="EF_TS"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00889.21"
                     /description="Elongation factor TS"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1281_0065"
                     /evalue="9.20E-68"
                     /label="ctg1_1281"
                     /locus_tag="ctg1_1281"
                     /protein_end="323"
                     /protein_start="70"
                     /score="228.0"
                     /tool="antismash"
                     /translation="AAVVEVNAETDFVAKNAQFVELVNATAKVIAEGKPANNEEALALT
                     MPSGETLEAAYVSATATIGEKISFRRFALLEKTDAQHFGAYQHNGGRIGVISVIEGGDE
                     ALAKQISMHIAAMKPTVLSYKELDAQFVKDELAQLNHVIDQDNESRAMVGKPALPHLKF
                     GSKAQLTDEVIAQAEADIKAELATEGKPEKIWDKIIPGKMDRFMLDNTKVDQAYTLLAQ
                     VYIMDDSKTVEAYLESVNASVVEFARFEVGE"
     CDS             5001..7154
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="resistance (resist) ABC_efflux (Score:
                     246.9; E-value: 2.5e-75)"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 331.9; E-value:
                     1.3e-100)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_1282"
                     /sec_met_domain="TIGR01193 (E-value: 0.0, bitscore: 1095.9,
                     seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_C39 (E-value: 8.5e-41, bitscore:
                     135.5, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKFKKKHYRPQMDQMDCGVASLAMVFSYFGSYYSIARLRELAKTT
                     KNGTTALGIVKVAEKLGFETQAIQADMTLFDLPDLPLPFLVHVLKEGELLHYYVVIGHD
                     KESIHIADPDPDIRLTKLSRERFEEEWTGTTIFMAPAPNYQPHQDKKQDLTSFLPILVN
                     QKGLIVNIILAAFLVTLINIVGSYYLQSIIDTYVPNQTSSTLGIISVGLIIVYILQQIL
                     SYAQDYLLHVLGQRLSIDIILSYIKHVFDLPMSFFATRRTGEIISRFTDANSIIDAVAS
                     AVISVFLNISTVLIISVILFVQNSNLFFMTLLAIPIYTIIIVAFMKPFEKMNRDTMAAN
                     ATLSSSIIEDINGIETIKSLTSEKIRYKKIDSEFVDYLKKSFTYGQAESQQKALKKLAQ
                     LLLNVCILWTGANLVMDGKMSLGQLITYNALLFYFTNPLENIINLQSKLQTAQVANNRL
                     NEVYQVKSEFEEQKIVEDLSMIHGDLTFKEIHYRYDYGRDILSGINLTIEQGSKIAFVG
                     VSGSGKSTLAKMMVNFYNPSQGEIRLGGMNLNQIDKKSLRQHINYLPQQPYVFNGTILE
                     NLLLGAKEDTTQEDILRAVEIAEIREDIERMPLNYQTELTSDGVGISGGQRQRIALARA
                     LLTDAPILILDEATSSLDILTEKRIMENLMSLDKTLIFIAHRLTIAERVDKVVVLNQGK
                     IVEEGKHTELITQDGFYANLVNC"
     PFAM_domain     5016..5426
                     /aSDomain="Peptidase_C39"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03412.17"
                     /description="Peptidase C39 family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1282_0066"
                     /evalue="1.00E-39"
                     /label="ctg1_1282"
                     /locus_tag="ctg1_1282"
                     /protein_end="142"
                     /protein_start="5"
                     /score="135.5"
                     /tool="antismash"
                     /translation="KHYRPQMDQMDCGVASLAMVFSYFGSYYSIARLRELAKTTKNGTT
                     ALGIVKVAEKLGFETQAIQADMTLFDLPDLPLPFLVHVLKEGELLHYYVVIGHDKESIH
                     IADPDPDIRLTKLSRERFEEEWTGTTIFMAPAP"
     aSDomain        5031..7148
                     /aSDomain="TIGR01193"
                     /aSTool="tigrfam"
                     /description="bacteriocin_ABC: ABC-type bacteriocin
                     transporter"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1282_0033"
                     /evalue="0.00E+00"
                     /identifier="TIGR01193"
                     /label="ctg1_1282"
                     /locus_tag="ctg1_1282"
                     /protein_end="716"
                     /protein_start="10"
                     /score="1095.9"
                     /tool="antismash"
                     /translation="QMDQMDCGVASLAMVFSYFGSYYSIARLRELAKTTKNGTTALGIV
                     KVAEKLGFETQAIQADMTLFDLPDLPLPFLVHVLKEGELLHYYVVIGHDKESIHIADPD
                     PDIRLTKLSRERFEEEWTGTTIFMAPAPNYQPHQDKKQDLTSFLPILVNQKGLIVNIIL
                     AAFLVTLINIVGSYYLQSIIDTYVPNQTSSTLGIISVGLIIVYILQQILSYAQDYLLHV
                     LGQRLSIDIILSYIKHVFDLPMSFFATRRTGEIISRFTDANSIIDAVASAVISVFLNIS
                     TVLIISVILFVQNSNLFFMTLLAIPIYTIIIVAFMKPFEKMNRDTMAANATLSSSIIED
                     INGIETIKSLTSEKIRYKKIDSEFVDYLKKSFTYGQAESQQKALKKLAQLLLNVCILWT
                     GANLVMDGKMSLGQLITYNALLFYFTNPLENIINLQSKLQTAQVANNRLNEVYQVKSEF
                     EEQKIVEDLSMIHGDLTFKEIHYRYDYGRDILSGINLTIEQGSKIAFVGVSGSGKSTLA
                     KMMVNFYNPSQGEIRLGGMNLNQIDKKSLRQHINYLPQQPYVFNGTILENLLLGAKEDT
                     TQEDILRAVEIAEIREDIERMPLNYQTELTSDGVGISGGQRQRIALARALLTDAPILIL
                     DEATSSLDILTEKRIMENLMSLDKTLIFIAHRLTIAERVDKVVVLNQGKIVEEGKHTEL
                     ITQDGFYANLVN"
     PFAM_domain     5505..6314
                     /aSDomain="ABC_membrane"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00664.25"
                     /description="ABC transporter transmembrane region"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1282_0067"
                     /evalue="1.90E-60"
                     /label="ctg1_1282"
                     /locus_tag="ctg1_1282"
                     /protein_end="438"
                     /protein_start="168"
                     /score="204.9"
                     /tool="antismash"
                     /translation="VNIILAAFLVTLINIVGSYYLQSIIDTYVPNQTSSTLGIISVGLI
                     IVYILQQILSYAQDYLLHVLGQRLSIDIILSYIKHVFDLPMSFFATRRTGEIISRFTDA
                     NSIIDAVASAVISVFLNISTVLIISVILFVQNSNLFFMTLLAIPIYTIIIVAFMKPFEK
                     MNRDTMAANATLSSSIIEDINGIETIKSLTSEKIRYKKIDSEFVDYLKKSFTYGQAESQ
                     QKALKKLAQLLLNVCILWTGANLVMDGKMSLGQLITYNALLFYFTNPL"
     PFAM_domain     6498..6950
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1282_0068"
                     /evalue="4.40E-33"
                     /label="ctg1_1282"
                     /locus_tag="ctg1_1282"
                     /protein_end="650"
                     /protein_start="499"
                     /score="114.8"
                     /tool="antismash"
                     /translation="LSGINLTIEQGSKIAFVGVSGSGKSTLAKMMVNFYNPSQGEIRLG
                     GMNLNQIDKKSLRQHINYLPQQPYVFNGTILENLLLGAKEDTTQEDILRAVEIAEIRED
                     IERMPLNYQTELTSDGVGISGGQRQRIALARALLTDAPILILDEATS"
     CDS             7167..8060
                     /locus_tag="ctg1_1283"
                     /transl_table=11
                     /translation="MHKEFLESAEFYNRRYHNFSSRVILPMSFLIVFLFGFSVFAEKEI
                     SLSSKATVEPSRIISNIQSASNQRMVANHMEENKRVQRGELLVQYQKIGDEIQSEVYNS
                     RFEMPQDYKSKASGLKNSEVQQKISITSQKPQKQEILEGKLGKNSQSRFLEEGVIRAEE
                     DGILHLNPEIGQSSVVAEGTPLAKLYPPLDREGKTKLTAYLSSKDIMGIQIGDPVRFTT
                     SNDNNNQVLLVSKITGIDTIATRTDQGNFFKIEAETSVTEEEAKNLRYGLEGRLRIMIG
                     KKSYFRYYLDEFLNRD"
     PFAM_domain     7638..7979
                     /aSDomain="HlyD_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13437.8"
                     /description="HlyD family secretion protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1283_0069"
                     /evalue="3.30E-10"
                     /label="ctg1_1283"
                     /locus_tag="ctg1_1283"
                     /protein_end="271"
                     /protein_start="157"
                     /score="40.7"
                     /tool="antismash"
                     /translation="VIRAEEDGILHLNPEIGQSSVVAEGTPLAKLYPPLDREGKTKLTA
                     YLSSKDIMGIQIGDPVRFTTSNDNNNQVLLVSKITGIDTIATRTDQGNFFKIEAETSVT
                     EEEAKNLRYG"
     CDS             8225..8932
                     /locus_tag="ctg1_1284"
                     /transl_table=11
                     /translation="MSDKLIYTGKAKDIYTTEDENVIKSVYKDQATMLNGARKETIKGK
                     GVLNNQISSLIFEKLNAAGVATHFIERISDTEQLNKKVKIIPLEVVLRNVTAGSFSKRF
                     GVEEGLELETPIVEFYYKNDELDDPFINDEHVKFLGVANDEQIAYIKAETRRINELLKD
                     WFAQIGLRLIDFKLEFGFDKDGKIILADEFSPDNCRLWDAEGHHMDKDVFRRDLGSLTD
                     VYEVVLEKLQGLK"
     aSDomain        8240..8836
                     /aSDomain="TIGR00081"
                     /aSTool="tigrfam"
                     /description="purC:
                     phosphoribosylaminoimidazolesuccinocarboxamide synthase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1284_0034"
                     /evalue="1.80E-71"
                     /identifier="TIGR00081"
                     /label="ctg1_1284"
                     /locus_tag="ctg1_1284"
                     /protein_end="204"
                     /protein_start="5"
                     /score="238.8"
                     /tool="antismash"
                     /translation="IYTGKAKDIYTTEDENVIKSVYKDQATMLNGARKETIKGKGVLNN
                     QISSLIFEKLNAAGVATHFIERISDTEQLNKKVKIIPLEVVLRNVTAGSFSKRFGVEEG
                     LELETPIVEFYYKNDELDDPFINDEHVKFLGVANDEQIAYIKAETRRINELLKDWFAQI
                     GLRLIDFKLEFGFDKDGKIILADEFSPDNCRLWDAE"
     PFAM_domain     8240..8908
                     /aSDomain="SAICAR_synt"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01259.20"
                     /description="SAICAR synthetase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1284_0070"
                     /evalue="2.10E-64"
                     /label="ctg1_1284"
                     /locus_tag="ctg1_1284"
                     /protein_end="228"
                     /protein_start="5"
                     /score="217.7"
                     /tool="antismash"
                     /translation="IYTGKAKDIYTTEDENVIKSVYKDQATMLNGARKETIKGKGVLNN
                     QISSLIFEKLNAAGVATHFIERISDTEQLNKKVKIIPLEVVLRNVTAGSFSKRFGVEEG
                     LELETPIVEFYYKNDELDDPFINDEHVKFLGVANDEQIAYIKAETRRINELLKDWFAQI
                     GLRLIDFKLEFGFDKDGKIILADEFSPDNCRLWDAEGHHMDKDVFRRDLGSLTDVYEVV
                     L"
ORIGIN
        1 gtagatgagg ttcaaactaa ggttacagct attcaaactg aacaagaaaa gttacaaact
       61 gagaatgaaa aacttcaaga agaatctaaa aagcttgaag gtgaaatcac agaactttca
      121 aaaaatatcg tagctcgtaa tgaatcactt gaaaaccaag ctcgcagtgc ccaaactagc
      181 ggaactgcta caagctacat taacacgatt atcaattcta actcaatcac agaagctatt
      241 tctcgtgtag cagctatgag tgaaatcgta tcagccaata acaagatgtt ggagcaacaa
      301 aaagaagata agaaagctat ttctgaaaaa caagttgcaa acaacgaagc aatcaataca
      361 gttattgcaa atcaacaaac gcttgctgac gatgctcaag ctttgacaac aaaacaagca
      421 gaattgaaag tagctgagtt aaatcttgca gctgaaaaag ctacagcaga gaacgataaa
      481 gctagcttgt tagagaagaa agccgcagcg gaggcagaag ccaaagccgc agcagaagca
      541 gaggcagctt ataaagctaa acaagcaagt caacaacagt cgcttgcagc ttcagctaac
      601 acaacttttg ctgcacaagt acaagcaact tcaagctctt cttcatcatc agatgatgat
      661 tcaagctaca cacccgcagc aacgactgta agtcaactac caacttatag ttcaaacgct
      721 tctagttacc ctgcaggtca atgtacgtgg ggtgctaaga ccttggctcc atgggctggt
      781 gattactggg gtaatggtgg tcagtgggct actagtgcag cagcagcagg tttccgtaca
      841 ggttctatac cacaagttgg tgcgattgct tgttgggatg atggtggcta tggacacgta
      901 gcggttgtta ctgccgttga gtcaacaaca cgtatccaag tttcagaatg taactatgat
      961 ggtagtggta ctcaaccaat cggaaattac cgtggatggt ttaatcctac agcatcacgt
     1021 ggtacagtaa gatacattta tccaaactaa tatactgatt attattcaat ttagggtgag
     1081 gttttatgaa tctcaccctt tgtatagtgt ttaaaaaata aatttcatca tatcatgatt
     1141 agtcattgac atattatttt cattcgttta ggtaaaacta gatgaaatat agagaattag
     1201 cacataaaca agttggtgga gataaaatag attttaagag agttggtact ggaattatgt
     1261 ttacttataa aatgaatgtt gatgttcaag agtgggattt atttttacaa aatcatcctc
     1321 aaggaaatct attgcaaagt agtgattggt ccaagataaa gaatacctgg gggaatgagc
     1381 gagttgggtt ttataaagat gaccaattgg ttggggtagc gaatatttta attcaacctc
     1441 ttccattagg gctttctatg ttctatattc cacgtggtcc agttattgat tatactgata
     1501 aagaacttct gaaatttgta cttttatcgt tgaaaaagct tgctaaaaaa agccgtgcaa
     1561 taatggttaa atttgatcca agtctattta tcagtcgaac ttttattggt caagaatctg
     1621 ttcaggattc tagaacttta gaaatcgtag aggaattaca gaggaataaa gttcattgga
     1681 caggcttaac aaaggatatg gcggaaaaca tacaaccgcg ttttcaagct aatattcata
     1741 aagaaaattt ctcactagat caactttcta agtctactag acaggcaatc cgaactgcaa
     1801 aaaataaagg attggaagtg aaatttggcg gactcgattt attagatgag ttttcatttt
     1861 taatgaagaa aacagagaat cgcaaaaata ttagtttacg aggaaaagat tattatcaga
     1921 aattactgaa cacttatcct aatcactcct ttatcacaat gagctatata gatttgccta
     1981 atagactgga agaagttgag cagcaacttg aaaagaatct aaaaatagca cagaaattta
     2041 ctgataaaac gaaagaaggc aaaataaaag agaatcagca agagagaaaa cgattagagg
     2101 aagaagtttc ttttcttaag agttgtattg atagaggaga tagtgttgtt ccactatccg
     2161 cgactttgac gatcgaattt ggtaaagctt ctgagaactt atacgcgggg atgaatgaag
     2221 agtttagaca ctatcaacct gctattccaa catggtttga gactgcccaa cattcatttg
     2281 aacgtggggc agagactcat aatatgggtg gaattgaaaa tagtttagaa ggtgggttat
     2341 ttaattttaa atctaaattt aatcccacta tagaggaatt tgctggtgaa tttaattacc
     2401 caactagttc attgtatttc ttgtttaata tagcctataa aattcgcaag aagcttcgga
     2461 gtagatagga caaactaatt attttgtcac tatattgaat taaaaaaatt agctattaga
     2521 gcatctcagc agtatatgtt gaggtgcttt tattttagaa cttgtaattg atgattcaat
     2581 gaaaaaaata agaatgttgc ttgaaataac cctataatta tggtaaaata aaatttgtcg
     2641 tgtgaacgat aatactcatt cttgatgaat tgtgaagccg ttgcctttag gtcgttttgc
     2701 aagttgaaat caagaagagg aaaaaacaaa aaggagaaat actcatggca gtaatttcaa
     2761 tgaaacaact tctcgaggct ggtgtacact ttggtcacca aactcgtcgc tggaacccta
     2821 agatggctaa gtacatcttc actgaacgta acgggattca cgttatcgac ttgcaacaaa
     2881 ctgtaaaata cgctgaccaa gcatatgact ttatgcgtga tgcagcagct aacgatgcag
     2941 ttgtattgtt cgttggtact aagaaacaag cagctgatgc agttgctgaa gaagcagtac
     3001 gttcaggtca atacttcatc aaccaccgtt ggttgggtgg aactcttaca aactggggaa
     3061 caatccaaaa acgtatcgct cgtttgaaag aaatcaaacg tatggaagaa gatggaactt
     3121 ttgaagttct tcctaagaaa gaagttgcac ttcttaacaa acaacgtgca cgtcttgaaa
     3181 aattcttggg tggtatcgaa gatatgcctc gtatcccaga tgtaatgtac gttgtagatc
     3241 cacataaaga acaaatcgct gttaaggaag ctaagaaatt gggtatccca gttgtagcga
     3301 tggtcgacac aaacactgac ccagatgata tcgatgtaat tatcccagct aacgatgacg
     3361 ctattcgcgc tgtaaaattg attacagcta aattggctga tgctatcatc gaaggtcgtc
     3421 aaggtgaaga tgcaacagca gttgaagctg aatttgcagc ttcagaagca caagctgact
     3481 caatcgaaga aatcgttgaa gttgtagaag gcgacaacgc ttaattcaaa taagtaatca
     3541 ttacctagga gggcggggct tagcccggct ctcctatttt taaaaaatat aggagaatca
     3601 aaatggcaga aattacagct aaacttgtta aagagttgcg tgaaaaatct ggtgctggtg
     3661 ttatggacgc taagaaagca ttggttgaag ttgaagggga tatcgaaaaa gcgattgaat
     3721 tgcttcgcga aaaaggtatg gctaaggcag ctaagaaagc tgaccgtgtt gctgcggaag
     3781 gtttgactgg tgtatatgtt aacggaaacg ttgcagcagt agttgaagta aatgctgaaa
     3841 ctgacttcgt tgcgaaaaac gctcaattcg ttgagttggt aaatgctaca gctaaagtaa
     3901 ttgctgaagg aaaaccagct aacaacgaag aagcacttgc tttgacaatg ccttcaggtg
     3961 aaacacttga agctgcatat gtatctgcaa cagctacaat cggtgaaaaa atctcattcc
     4021 gtcgttttgc tttgcttgaa aaaacagatg cacaacactt cggagcatac caacacaatg
     4081 gtggacgtat cggtgttatc tctgtaatcg aaggtggaga cgaagcgctt gctaaacaaa
     4141 tctcaatgca tatcgctgcg atgaaaccaa cagttctttc atacaaagaa ttggatgcac
     4201 aatttgtaaa agatgaattg gctcaattga accacgtgat tgaccaagat aacgaaagtc
     4261 gcgcaatggt tggtaaacca gcacttccac acttgaaatt cggttcaaaa gcacaattga
     4321 ctgacgaagt aatcgctcaa gctgaagctg atattaaggc tgaattggct acagaaggta
     4381 aaccagaaaa aatctgggat aaaatcattc caggtaaaat ggaccgcttc atgcttgaca
     4441 acactaaagt tgaccaagcc tacactcttc ttgcacaagt ctacatcatg gatgacagca
     4501 agacagttga agcatacctt gaatcagtta acgcttcagt agttgagttc gctcgttttg
     4561 aagttgggga aggtatcgag aaagcttcaa atgattttga agctgaagtt gcagctacaa
     4621 tggcagcagc tttgaataac taataatcta ataaaaaagg aagcagactt gcttcctttt
     4681 ttttttatag aattttgcta atctcgaata gttggataag tggtctgagt aaaggttttg
     4741 attctacggt tagttaccta tctcatttta ctaggtttaa gtatattcat actcttgaag
     4801 ttcatctaaa cagtttctgt gattagcaga gcatttaatc taacgatttt ataaattcat
     4861 atgttctttc taatggttta acagtgtagt ttaagtgtag atactgtttt tatagaaaga
     4921 attttaactt ttgtactgcg tttggataaa ataatcttac aaaatttttt caatagatta
     4981 ttagaaaaaa ggataaggtt atgaaattca agaaaaaaca ctaccgccca cagatggacc
     5041 agatggactg tggagttgct tcgctagcta tggtatttag ctattttggg agctactatt
     5101 caatagctcg tttgcgtgaa ttagctaaga caactaaaaa tggaacaaca gctttaggga
     5161 ttgtgaaggt tgcagagaaa ctagggtttg agactcaagc tattcaagca gatatgacct
     5221 tgtttgattt acctgatttg cccctgcctt ttctagttca tgtactgaag gaaggagaat
     5281 tacttcatta ttatgtagta attggacatg ataaggagag tattcatata gctgatccag
     5341 atccagatat tagattgacc aaactatcgc gtgagagatt tgaagaagaa tggacgggga
     5401 caactatctt tatggctcct gctccaaatt atcagcctca tcaggacaag aaacaggatt
     5461 tgacttcttt tctacctatt ttggtaaatc agaaagggtt gattgtgaat atcattttag
     5521 cggcttttct agtgaccttg attaatattg tcggttctta ctatctacag tctattattg
     5581 atacctatgt accaaatcag acatcatcga ctttgggcat tatttcagtc ggattgatta
     5641 ttgtttatat tcttcaacag attttatcct atgctcagga ttatttatta catgttctag
     5701 ggcaacgttt atcaattgat attattttat cttatattaa acatgttttc gatttaccca
     5761 tgtctttttt tgcaacacgt cgaacaggag aaatcatatc acgatttaca gatgctaata
     5821 gtatcataga cgccgtagct tcagccgtta tttcagtttt tttgaatata tctactgtgt
     5881 tgattatctc ggtaatctta tttgtacaaa acagcaatct cttttttatg actttattgg
     5941 ctattcccat ctatactata ataattgtcg cttttatgaa gccttttgaa aagatgaatc
     6001 gagataccat ggcagccaat gcaactttat cgtcttctat catagaggac atcaatggca
     6061 ttgaaacgat taagtccttg actagcgaaa aaatacgcta caaaaagatt gatagtgaat
     6121 ttgtggacta tctaaaaaaa tcctttactt atggtcaagc agaaagccag caaaaagctc
     6181 ttaaaaaact tgctcaactt ttattaaatg tctgtatttt atggacgggg gctaatcttg
     6241 taatggatgg gaaaatgagc ttgggacagt taattaccta taatgcactt cttttttatt
     6301 tcacaaatcc attagagaat attatcaatc ttcagagtaa acttcaaacg gctcaagttg
     6361 caaataaccg actcaatgaa gtgtatcaag ttaaatctga gtttgaagag cagaaaatag
     6421 tagaggattt gagcatgatt catggggatc tgaccttcaa ggaaattcac tacaggtatg
     6481 attatggtcg agatatttta tctggcatta atttgactat cgaacaaggt tctaaaatag
     6541 cttttgtagg agtttcgggt tcagggaagt caaccttggc taagatgatg gttaattttt
     6601 ataatccgag tcagggagaa atcaggttgg gaggtatgaa tttgaatcag attgataaaa
     6661 aatccttacg ccaacatatc aactatttac cccaacaacc ctatgtattc aatggaacaa
     6721 ttttagaaaa tctcctcctt ggagctaagg aggatacgac tcaagaggat atactacgtg
     6781 cagtcgagat agcagaaatc cgtgaagata ttgagcgtat gcccttgaat taccaaacgg
     6841 aattaacttc tgatggcgtt ggaatttctg gtggtcaacg tcagaggatt gctttggcac
     6901 gtgctctctt gacagatgca ccaattttga ttttggatga ggcaacaagt agtctggata
     6961 tcttaacaga gaagcggatt atggaaaatc tcatgagtct agataaaaca ctgattttca
     7021 ttgcacatcg cttgactatt gctgagcggg tggataaagt ggtcgttttg aatcagggga
     7081 agattgtcga agagggaaag catacggaat taatcaccca ggatggtttt tacgccaatt
     7141 tagttaattg ttagaaagag aaaagaatgc ataaagaatt tttagaaagt gcggagtttt
     7201 ataatcgacg ttaccataat ttttcaagtc gtgtgatttt gccgatgtca tttttgatag
     7261 tgtttttgtt tgggttttca gtgtttgcag aaaaggagat tagcttatct tcgaaagcta
     7321 ctgttgaacc cagtcgcatc atctccaata tccaatcagc tagtaatcag agaatggtag
     7381 ccaatcatat ggaagagaac aaacgggtac aacgaggaga attactcgtt cagtatcaga
     7441 aaataggaga tgaaattcaa tctgaagttt ataatagtcg gtttgagatg ccacaagact
     7501 ataaaagtaa agcaagtggt ctcaaaaata gtgaggtgca gcagaaaata agcatcactt
     7561 ctcagaaacc tcaaaagcaa gaaattttag aaggaaaatt aggtaaaaac agtcaatctc
     7621 gttttcttga agaaggggta atcagagctg aggaagatgg gatccttcac cttaatcctg
     7681 agataggtca atcttcggta gtcgcagaag gaaccccgct tgccaaacta tatcccccat
     7741 tggataggga agggaaaaca aaattgacag cttatcttag ttcaaaagat atcatgggaa
     7801 tccagattgg agatcctgtg cgctttacca caagtaacga caataataat caggtgttgc
     7861 tcgtttctaa gattactggc atagatacaa ttgcaaccag aactgatcaa ggaaatttct
     7921 ttaaaataga agcagaaaca agcgttaccg aggaagaagc taaaaatctt agatacggat
     7981 tagaggggcg tctacgaata atgataggta aaaagagtta ttttcgctat tatctagatg
     8041 aatttttgaa tagagactaa tgttcgttct cttattaaat aatttttaaa aactgtattc
     8101 caaaatggat tgcagttttt atttaccaat ggtacggcgc attctatttt attcgtaaaa
     8161 ttcttgaatt tctatgactt ttgtggtaaa atgtgctcaa gtaatacgaa aggcgaacaa
     8221 taaaatgtca gacaaattaa tttatacggg aaaagctaaa gatatctata ctacagaaga
     8281 cgaaaatgtg attaaatcgg tctataagga tcaagcaacc atgcttaatg gtgctcgtaa
     8341 ggagactatt aaggggaaag gcgtgctgaa taatcagatt tcgtctctta tttttgaaaa
     8401 attgaacgct gccggtgtgg caacacactt tatcgaacgt atttctgata ccgaacaatt
     8461 gaataagaag gttaaaatta ttcctttgga agttgttctt cgaaacgtga ctgcaggttc
     8521 attttcaaag cgttttggcg ttgaagaagg gttggaattg gaaactccaa tcgttgaatt
     8581 ttactataaa aacgatgagc tggatgatcc gtttatcaac gacgaacacg tgaaattctt
     8641 gggtgttgcc aatgatgaac aaattgctta tatcaaggca gaaacacgcc gtatcaatga
     8701 gttgttgaag gattggtttg cccaaatcgg ccttcgtttg attgacttca aattggaatt
     8761 tggttttgat aaggatggca agatcatctt ggcagatgag ttttcaccag ataactgtcg
     8821 cctttgggat gcggaaggac accacatgga caaggatgtt ttccgtagag atttgggcag
     8881 tctgacagat gtttatgaag ttgtattgga aaaattgcaa ggcttgaagt aattttttga
     8941 attcctctcc aatacagttt ttagtagaaa taaataaagg aaataaaatg gataaacgta
     9001 ttttcgttga gaaaaaagct gattttcgtg tgaaatcgga ctctttagta aaagaattac
     9061 agcataatct tcagttgaaa accttgaagg atcttcgtat tgttcaggta tacgatgtct
     9121 ttaatttggc agaggacttg tttgggcgtg cagaaaaaca tatcttctct gaacaagtga
     9181 ccgatactgt tttagatgaa gctgcggtta aggctgatct tgagaaggtt gctttctttg
     9241 ctatcgaaag cttacctggt caatttgacc aacgtgcggc ctcttcacaa gaagctttgc
     9301 tgttgcttgg tagttcaaat gatgtgacgg ttaataccgc gcaactttac ttggttaaca
     9361 aggatattgc tactaatgaa ttggaagctg tcaaaaacta cctcttgaac ccagtggatt
     9421 ctcgtttcaa agatatcact gttggtattg cgaaacagga tttctctgag tccgacaaga
     9481 ctattccaaa cttggatttc tttgaaactt atgtggctga agattttgct aagtataagg
     9541 cagagcaagg attggccatg gaagtggatg accttctctt cattcaagat tactttaagt
     9601 ctattggacg tgtgccaact gagactgagt taaaggtttt ggatacttat tggtccgacc
     9661 actgccgtca cacaactttt gagacagagt tgaaaaacat cgacttctca gcttctaaat
     9721 tccaaaaaca attgcaagcg acttatgaca agtatatcgc catgcgtaat gagttgggac
     9781 gtacagaaaa acctcaaacc ttgatggata tggcgactat ttttggtcgt tatgagcgtg
     9841 ccaatggtcg tttggatgac atggaagtgt ctgatgaaat caatgcctgc tctgttgaaa
     9901 ttgaagtgga tgtcaatggt gtcaaagaac catggcttct catgttcaag aacgaaactc
     9961 acaaccaccc aacggaaatc gaaccatttg gtggagcggc tacttgtatc ggtggtgcca
    10021 ttcgtgaccc attgtcagga cgttcctacg tttaccaagc gatgcgtatc tcaggtgctg
    10081 gtgatattac agctccaatt tcagcgactc gcgctggtaa attgccgcaa caagtcattt
    10141 ctaaaacagc ggctcacggt tattcttcat atgggaacca aattggtctt gcaacaactt
    10201 atgttcgtga atacttccac ccaggtttcg ttgctaagcg tatggaacta ggtgctgttg
    10261 tcggtgcggc tcctaaggaa aatgttgtcc gtgaaaaacc tgaagcaggt gatgtgatta
    10321 tcttgctcgg tgggaagact ggacgtgatg gtgtcggtgg tgcgacaggt tcttctaaag
    10381 ttcaaacggt tgaatctgtt gaaacagctg gtgctgaggt tcaaaaaggg aatgccatcg
    10441 aagaacgtaa aattcaacgt cttttccgta atggggaagt gacacgtctg atcaagaaat
    10501 caaatgactt tggtgctggt ggtgtctgtg tggctatcgg tgaattggca gatggtcttg
    10561 aaattgatct agacaaagtg ccattgaaat atcaaggctt gaacggtaca gaaattgcca
    10621 tctctgaatc tcaagagcgt atggctgtag tggttcgtcc agaagacgta gatgccttca
    10681 ttgcagcatg taacaaagaa aatattgatg cagttgtcgt tgcaacagta actgaaaaac
    10741 caaaccttgt catgcactgg aatggtgaaa caatcgttga tttggaacgt cgtttccttg
    10801 atacaaacgg tgtacgtgtg gtcgtagatg ctaaggtggt tgacaaggat gtcaagcttc
    10861 cagaagaacg tcaaacatct gctgaaacac ttgaagcaga tactcttgca gtcttggctg
    10921 accttaacca tgccagtcaa aaaggtttgc aaaccatctt tgatagttca gttggtcgtt
    10981 caacagtcaa tcatccactt ggtggtcgct accaaatcac accaactgaa gcttctgtac
    11041 agaaattgcc agttcaacat ggcgtgacaa caactgcctc tgtcatggcg caaggattca
    11101 acccttatgt agcagaatgg tctccatatc atggtgctgc ttatgcggtt atcgaagcaa
    11161 ctgctcgttt ggttgctgct ggtgcaaact ggtctaaggc tcgtttctct tatcaagaat
    11221 acttcgagcg tatggataaa caagcagagc gttttggcca accagtatca gctcttcttg
    11281 gatcaatcga agctcagatt caacttggtt tgccgtctat cggtggtaaa gactctatgt
    11341 ctggtacttt tgaagaattg acagtaccac caaccttggt tgcctttggt gtgacaacag
    11401 cagatagccg taaggtcctt tctccggaat ttaaagctgt tggtgaaaat atctattaca
    11461 tcccaggtca agctttgaca caggaaattg actttgatct tatcaagtct aactttgctc
    11521 agtttgaagc catccaggca gaccacaaag tcacagcagc atcagcggtc aaatatggtg
    11581 gtatccttga agctcttgca cttgcaacgt ttgggaacca tatcggtgcc actgtaagcc
    11641 ttgaaaatat tgagactgct ttgacagctc aattaggtgg attcatcttc acatctccgg
    11701 aagagatttc aggtgttgcc aagattggac aaacagcagc tgactttaca cttactgtca
    11761 acgatgtaag gcttgatgga cacaaacttg acagtgcctt ccaaggtaaa ttggaagaag
    11821 tttacccaac ggaatttgca caagcaattg agttggaaga agttcctgct gtggcatcag
    11881 atgctgtcat caaagctaaa gaaacagttg agacaccagt ggtttacatc ccagtgttcc
    11941 caggtactaa ctctgaatac gattcagcta aggcctttga aaaagaaggt gcgaaagtca
    12001 acttagtacc atttgtcaca ctgaatgaag aagcgattgt caagtctgtt gacaccatgg
    12061 ttgacaatat cggaaaagct aacattatct tctttgccgg tggattctca gcagcggatg
    12121 aaccagatgg atcagctaaa tttatcgtta acat
//
