LOCUS       NZ_CP026321.1          10927 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP026321.1 Vibrio campbellii strain BoB-53 chromosome 1, complete
            sequence.
ACCESSION   NZ_CP026321
VERSION     NZ_CP026321.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 12:51:35
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 38126
            Orig. end    :: 49053
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10927
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[43126:44053](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5927)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10927
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10927
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(1135..2106)
                     /gene_functions="regulatory (smcogs) SMCOG1125:LysR family
                     transcriptional regulator (Score: 256.5; E-value: 5.6e-78)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_29"
                     /transl_table=11
                     /translation="MTIIPMGKITVNVEKLARIDLNLLVCFKVLIEELNVTRAAHRLCL
                     SQSAVSKSLAKLRTQFDDPLFTRNSHGLTPTPRALFLKPKLDLLINQLEVLTQPEEFSP
                     QSSEYRFQIAAVESVYPLILPHFLPAIFQQAPGVTISTHSWSEQTFKMIQRGEIDLGMT
                     GRDIDINDAKLTMLPPDDICEQEIYRDHQMCIVRKDHPALRGNWNLEAYLALRHVQVRC
                     DGNDRWLLDYRLADIGRERDIAVTVPDFNSAASLCSYTDFVFTAPSHFVKLAAKQHDMA
                     LLPLPLEFPPMAYTLFWHRDRENDPALTWLRTMITQKTDHLR"
     PFAM_domain     complement(1153..1791)
                     /aSDomain="LysR_substrate"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03466.22"
                     /description="LysR substrate binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_29_0002"
                     /evalue="1.50E-30"
                     /label="ctg1_29"
                     /locus_tag="ctg1_29"
                     /protein_end="318"
                     /protein_start="105"
                     /score="106.2"
                     /tool="antismash"
                     /translation="SSEYRFQIAAVESVYPLILPHFLPAIFQQAPGVTISTHSWSEQTF
                     KMIQRGEIDLGMTGRDIDINDAKLTMLPPDDICEQEIYRDHQMCIVRKDHPALRGNWNL
                     EAYLALRHVQVRCDGNDRWLLDYRLADIGRERDIAVTVPDFNSAASLCSYTDFVFTAPS
                     HFVKLAAKQHDMALLPLPLEFPPMAYTLFWHRDRENDPALTWLRTMITQK"
     PFAM_domain     complement(1870..2046)
                     /aSDomain="HTH_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00126.29"
                     /description="Bacterial regulatory helix-turn-helix
                     protein, lysR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_29_0001"
                     /evalue="3.10E-16"
                     /label="ctg1_29"
                     /locus_tag="ctg1_29"
                     /protein_end="79"
                     /protein_start="20"
                     /score="59.2"
                     /tool="antismash"
                     /translation="LNLLVCFKVLIEELNVTRAAHRLCLSQSAVSKSLAKLRTQFDDPL
                     FTRNSHGLTPTPRA"
     CDS             2183..3376
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 92.4; E-value:
                     3.4e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_30"
                     /transl_table=11
                     /translation="VSSHITNSKKQMALLTMLVLFSPLAIDIYLPALPLIASTFQVENA
                     LAQDTITWFLFAMGVGQLFAGPLADKLGRRTVALGGITIYALSALLAWSAQNIEWMLAA
                     RLLQGLGACATSVAAFATVRDIFGPEKSGKMISYLNGAICFIPALAPILGSWLTQQFDW
                     RANFSFMAGFAVIAGAMMFLGMKETNPATEKQAVFKLSRYWSVLSTPSFIFHASLCLMA
                     MAVILAYVTSAPGVLITGMGLSMNEFTFWFGLNAVFNIAACMLAPKFMDRWGTHNSLVV
                     GISLLAIAGVIMMVMKEHNTALAFMLPIFISSVGFAWILGAAAGKALEPFGDKAGTAAA
                     LLGLFQMSGSGLLVGTLQRLSLEPQTLIAIHMWVLLPALVILFSKAGKSWHAKLANA"
     aSDomain        2207..3322
                     /aSDomain="TIGR00710"
                     /aSTool="tigrfam"
                     /description="efflux_Bcr_CflA: drug resistance transporter,
                     Bcr/CflA subfamily"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_30_0001"
                     /evalue="9.40E-75"
                     /identifier="TIGR00710"
                     /label="ctg1_30"
                     /locus_tag="ctg1_30"
                     /protein_end="380"
                     /protein_start="8"
                     /score="250.4"
                     /tool="antismash"
                     /translation="KKQMALLTMLVLFSPLAIDIYLPALPLIASTFQVENALAQDTITW
                     FLFAMGVGQLFAGPLADKLGRRTVALGGITIYALSALLAWSAQNIEWMLAARLLQGLGA
                     CATSVAAFATVRDIFGPEKSGKMISYLNGAICFIPALAPILGSWLTQQFDWRANFSFMA
                     GFAVIAGAMMFLGMKETNPATEKQAVFKLSRYWSVLSTPSFIFHASLCLMAMAVILAYV
                     TSAPGVLITGMGLSMNEFTFWFGLNAVFNIAACMLAPKFMDRWGTHNSLVVGISLLAIA
                     GVIMMVMKEHNTALAFMLPIFISSVGFAWILGAAAGKALEPFGDKAGTAAALLGLFQMS
                     GSGLLVGTLQRLSLEPQTLIAIHMWVLLPALV"
     PFAM_domain     2231..3238
                     /aSDomain="MFS_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07690.18"
                     /description="Major Facilitator Superfamily"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_30_0003"
                     /evalue="5.90E-46"
                     /label="ctg1_30"
                     /locus_tag="ctg1_30"
                     /protein_end="352"
                     /protein_start="16"
                     /score="157.1"
                     /tool="antismash"
                     /translation="MLVLFSPLAIDIYLPALPLIASTFQVENALAQDTITWFLFAMGVG
                     QLFAGPLADKLGRRTVALGGITIYALSALLAWSAQNIEWMLAARLLQGLGACATSVAAF
                     ATVRDIFGPEKSGKMISYLNGAICFIPALAPILGSWLTQQFDWRANFSFMAGFAVIAGA
                     MMFLGMKETNPATEKQAVFKLSRYWSVLSTPSFIFHASLCLMAMAVILAYVTSAPGVLI
                     TGMGLSMNEFTFWFGLNAVFNIAACMLAPKFMDRWGTHNSLVVGISLLAIAGVIMMVMK
                     EHNTALAFMLPIFISSVGFAWILGAAAGKALEPFGDKAGTAAALLGLFQMSGSGL"
     CDS             3468..3749
                     /locus_tag="ctg1_31"
                     /transl_table=11
                     /translation="MSLTTYEMARILEQMEESPEKVMFGKLLNELGNQSSERIRSAAKQ
                     VPVPVLRDLVYQFQQVIESRKGEQVEQMAKDLAQQGISAEELMAYLNK"
     CDS             complement(3780..4235)
                     /locus_tag="ctg1_32"
                     /transl_table=11
                     /translation="MTDTVKNLVNRYDDLISTLQAGFVPLLLLFCRLWVAWVFFNSGLI
                     KLSSWDSTLYLFELEYQVPILPWELAAYLGTAAELVLPVFLALGLITRPMAAILFVFNI
                     IAVVSYPLLWEKGFYDHQLWGLMILVVIVWGPGPLSLDHILKKKITN"
     PFAM_domain     complement(3912..4157)
                     /aSDomain="DoxX"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07681.14"
                     /description="DoxX"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_32_0004"
                     /evalue="5.40E-18"
                     /label="ctg1_32"
                     /locus_tag="ctg1_32"
                     /protein_end="108"
                     /protein_start="26"
                     /score="65.5"
                     /tool="antismash"
                     /translation="LLLFCRLWVAWVFFNSGLIKLSSWDSTLYLFELEYQVPILPWELA
                     AYLGTAAELVLPVFLALGLITRPMAAILFVFNIIAVV"
     CDS             complement(4246..5004)
                     /locus_tag="ctg1_33"
                     /transl_table=11
                     /translation="MNLATLQSQFAKALHYQALGEDCDIASDEFTADERMQIYRNNFIV
                     SLSEVLSATYPMVEALLGKECFEQMARQHVLTYPLEEGNVAHYGEGFQDTIMQFSQVIA
                     QAPYSPEVARFEWHIDLARQAQYEQSNAAELKQLAALGEVSEEQQPALILHLKKGCRSF
                     DSSYAVFDLFGAIQTGQFEQLNINQLQQGVISIQANGEALCHALDANVFQLLQCLEQQL
                     SLSEIPEVLLAHLNSIMALDLVDGFTLKSI"
     PFAM_domain     complement(4723..4989)
                     /aSDomain="DUF2063"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09836.11"
                     /description="Putative DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_33_0005"
                     /evalue="2.30E-22"
                     /label="ctg1_33"
                     /locus_tag="ctg1_33"
                     /protein_end="94"
                     /protein_start="5"
                     /score="79.1"
                     /tool="antismash"
                     /translation="LQSQFAKALHYQALGEDCDIASDEFTADERMQIYRNNFIVSLSEV
                     LSATYPMVEALLGKECFEQMARQHVLTYPLEEGNVAHYGEGFQD"
     CDS             complement(5001..5927)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_34"
                     /sec_met_domain="DUF692 (E-value: 9.3e-90, bitscore: 297.9,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLKQRTFLFPHDLKKEFHVKHHTFHDHVGVGLRTPHLDYFSQNKP
                     KLSWLEIHSENYFQPNAAERHQLHALREQYQISCHGIGLSLGSVERVNQKHLAQLKALI
                     DAIDPILVSDHLSWSENGGHYFNDLLPLPYTEEALKVFTRNVNEVQDYLQREILIENPS
                     SYVKFQHSTISEWEFLTEVQKRTDCRLLLDLNNVYVSAFNHGFDCDTYLDAIPADKVDE
                     IHLAGFTIKQLDKGEIWIDTHSRPVSDEVWQLFAQWTKKHGPRHTLIEWDLDIPAPEVL
                     LGEAHKASQLLLQGAIPSEQSESRKAS"
     PFAM_domain     complement(5055..5846)
                     /aSDomain="DUF692"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05114.15"
                     /description="Protein of unknown function (DUF692)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_34_0006"
                     /evalue="5.40E-107"
                     /label="ctg1_34"
                     /locus_tag="ctg1_34"
                     /protein_end="291"
                     /protein_start="27"
                     /score="357.0"
                     /tool="antismash"
                     /translation="VGVGLRTPHLDYFSQNKPKLSWLEIHSENYFQPNAAERHQLHALR
                     EQYQISCHGIGLSLGSVERVNQKHLAQLKALIDAIDPILVSDHLSWSENGGHYFNDLLP
                     LPYTEEALKVFTRNVNEVQDYLQREILIENPSSYVKFQHSTISEWEFLTEVQKRTDCRL
                     LLDLNNVYVSAFNHGFDCDTYLDAIPADKVDEIHLAGFTIKQLDKGEIWIDTHSRPVSD
                     EVWQLFAQWTKKHGPRHTLIEWDLDIPAPEVLLGEAHKASQL"
     CDS             complement(5961..6221)
                     /locus_tag="ctg1_35"
                     /transl_table=11
                     /translation="MKKSNLAVTAAVTGLLALGGTMLTAAPAVAAEKEKCYGVSKAGKN
                     DCATKSSSCAGTSKEDNQKDAFVVVPKGLCDKLTGGSTSSS"
     PFAM_domain     complement(5976..6125)
                     /aSDomain="DUF2282"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF10048.11"
                     /description="Predicted integral membrane protein
                     (DUF2282)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_35_0007"
                     /evalue="7.70E-23"
                     /label="ctg1_35"
                     /locus_tag="ctg1_35"
                     /protein_end="82"
                     /protein_start="32"
                     /score="80.4"
                     /tool="antismash"
                     /translation="KEKCYGVSKAGKNDCATKSSSCAGTSKEDNQKDAFVVVPKGLCDK
                     LTGGS"
     CDS             6501..8675
                     /locus_tag="ctg1_36"
                     /transl_table=11
                     /translation="MMDPSLLLDGLNDKQREAVAAPLENLLVLAGAGSGKTRVLVHRIA
                     WLMSVEQSSPFSIMSVTFTNKAAAEMRGRIEELMMGSAGGMWNGTFHGICHRILRAHYL
                     DAKLPEDFQIIDSDDQQRLLKRLIKAQNLDEKQWPARQVAWWINGKKDEGLRPSHIDAY
                     HDPVTKTYLQLYTAYQEACDRAGLVDFAEILLRAHELLRDNKFVREHYQARFKHILVDE
                     FQDTNNIQYAWLRMMAGPECHVMIVGDDDQSIYGWRGAKVENIEKFTLEFPSVNTIRLE
                     QNYRSTKTILEASNALIANNTERMGKELWTDGVVGEPISVYSAYNELDEARFAVNKIKE
                     WQDKGGALNDAAMLYRNNAQSRVLEEALIQAGLPYRIYGGMRFFERQEIKDALSYMRLI
                     ANRNDDAAFERVVNTPTRGLGDKTLETIRFAARDRGCTMWEASVAMLDEKVLAGRAAGA
                     LSRFIELVTALEDDTIEMPLHHQTDHVIKYSGLFAMYEQEKGEKSKARIENLEELVTAT
                     RQFEKPEEAEDMSLLTAFLTHAALEAGEGQADEFEDAVQLMTLHSAKGLEFPLVFMVGV
                     EEGMFPSQMSAEEAGRLEEERRLCYVGMTRAMQKLYITYAEMRRLYGQDKYHKPSRFIR
                     ELPETCLDEVRMKAQVSRPASSGRFSQTAVKESFNETGFTLGSRVMHPKFGEGTIINFE
                     GSGPQSRVQIAFNGEGIKWLVTAYARLEKL"
     aSDomain        6519..8666
                     /aSDomain="TIGR01075"
                     /aSTool="tigrfam"
                     /description="uvrD: DNA helicase II"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_36_0002"
                     /evalue="0.00E+00"
                     /identifier="TIGR01075"
                     /label="ctg1_36"
                     /locus_tag="ctg1_36"
                     /protein_end="722"
                     /protein_start="6"
                     /score="1324.1"
                     /tool="antismash"
                     /translation="LLDGLNDKQREAVAAPLENLLVLAGAGSGKTRVLVHRIAWLMSVE
                     QSSPFSIMSVTFTNKAAAEMRGRIEELMMGSAGGMWNGTFHGICHRILRAHYLDAKLPE
                     DFQIIDSDDQQRLLKRLIKAQNLDEKQWPARQVAWWINGKKDEGLRPSHIDAYHDPVTK
                     TYLQLYTAYQEACDRAGLVDFAEILLRAHELLRDNKFVREHYQARFKHILVDEFQDTNN
                     IQYAWLRMMAGPECHVMIVGDDDQSIYGWRGAKVENIEKFTLEFPSVNTIRLEQNYRST
                     KTILEASNALIANNTERMGKELWTDGVVGEPISVYSAYNELDEARFAVNKIKEWQDKGG
                     ALNDAAMLYRNNAQSRVLEEALIQAGLPYRIYGGMRFFERQEIKDALSYMRLIANRNDD
                     AAFERVVNTPTRGLGDKTLETIRFAARDRGCTMWEASVAMLDEKVLAGRAAGALSRFIE
                     LVTALEDDTIEMPLHHQTDHVIKYSGLFAMYEQEKGEKSKARIENLEELVTATRQFEKP
                     EEAEDMSLLTAFLTHAALEAGEGQADEFEDAVQLMTLHSAKGLEFPLVFMVGVEEGMFP
                     SQMSAEEAGRLEEERRLCYVGMTRAMQKLYITYAEMRRLYGQDKYHKPSRFIRELPETC
                     LDEVRMKAQVSRPASSGRFSQTAVKESFNETGFTLGSRVMHPKFGEGTIINFEGSGPQS
                     RVQIAFNGEGIKWLVTAYARLE"
     PFAM_domain     6531..7316
                     /aSDomain="UvrD-helicase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00580.23"
                     /description="UvrD/REP helicase N-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_36_0008"
                     /evalue="9.40E-74"
                     /label="ctg1_36"
                     /locus_tag="ctg1_36"
                     /protein_end="272"
                     /protein_start="10"
                     /score="248.8"
                     /tool="antismash"
                     /translation="LNDKQREAVAAPLENLLVLAGAGSGKTRVLVHRIAWLMSVEQSSP
                     FSIMSVTFTNKAAAEMRGRIEELMMGSAGGMWNGTFHGICHRILRAHYLDAKLPEDFQI
                     IDSDDQQRLLKRLIKAQNLDEKQWPARQVAWWINGKKDEGLRPSHIDAYHDPVTKTYLQ
                     LYTAYQEACDRAGLVDFAEILLRAHELLRDNKFVREHYQARFKHILVDEFQDTNNIQYA
                     WLRMMAGPECHVMIVGDDDQSIYGWRGAKVENIEKFTLEF"
     PFAM_domain     7332..8351
                     /aSDomain="UvrD_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13361.8"
                     /description="UvrD-like helicase C-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_36_0009"
                     /evalue="3.50E-82"
                     /label="ctg1_36"
                     /locus_tag="ctg1_36"
                     /protein_end="617"
                     /protein_start="277"
                     /score="276.8"
                     /tool="antismash"
                     /translation="IRLEQNYRSTKTILEASNALIANNTERMGKELWTDGVVGEPISVY
                     SAYNELDEARFAVNKIKEWQDKGGALNDAAMLYRNNAQSRVLEEALIQAGLPYRIYGGM
                     RFFERQEIKDALSYMRLIANRNDDAAFERVVNTPTRGLGDKTLETIRFAARDRGCTMWE
                     ASVAMLDEKVLAGRAAGALSRFIELVTALEDDTIEMPLHHQTDHVIKYSGLFAMYEQEK
                     GEKSKARIENLEELVTATRQFEKPEEAEDMSLLTAFLTHAALEAGEGQADEFEDAVQLM
                     TLHSAKGLEFPLVFMVGVEEGMFPSQMSAEEAGRLEEERRLCYVGMTRAMQKLYITYAE
                     "
ORIGIN
        1 tcatacctgc gatttcaact gcgtttttcg ccgcttttgg cattaggcat gggtcagcct
       61 tactcactac tgacgcgcca gcattttgta gaaccagctt aaaccatgcg ttacttgtcg
      121 cagggtcaac cagtacattc ttgccagtta gagtttctag tcgtgcttgc aatgcttctg
      181 ggtgatgaac tgttacgcct gcacctacgt gagcgtcaaa ctcagcaggt aggcgagctg
      241 gatctagaaa gtattctacg cttgaatctg agtgcaggat cgcgtgagaa agcagaactg
      301 gtaggcgtga tacatctaga ccacgaacgt tgagtaacca acagatagaa tcaagtgctg
      361 ttatcactgc gctatctgcg ctggcttttt tcacgagctc agcgatttct tggcgtttgc
      421 tttcacttga ttggccaact gcttctgttg ccattaggcg aacatcagaa accacaggag
      481 cagggcggtc gtgccacagc tcatcaattg ggttgctgtc gagaatctta agctcaagtg
      541 cacctgcaag ttttgcttgt gccatgtcta accaagcaga gttgtgcata cgagggtcga
      601 ttgccacaga ggcgccattt gcaagatggt ctttaatcca atctagtgca ggctcttcaa
      661 tcaggtgacg gtattcgaat agatcagcag gaacctgctt agttacttgt accgtgtagc
      721 gaccatcaac aaagatagcg gctttgtctt tggtgattac cgcagcacca gcagaaccgg
      781 taaaaccagt tagccaatgt aaacgctcgt tgtgcgctgg tacgtattcg cccaagtact
      841 cgtcttcatg agggacaagt agggcatcaa tattatgttg tgctagccat tcgcgaattg
      901 cattcacgcg gctttgggta tcgttgtgca tctgtgttat tccttcaaat taccgctcct
      961 tcatgctcag gtgtgggagc tgtttccatc tgcttcatgc agtttacgat tccattgagg
     1021 ttcgcaatca cttcaataga gtcggagtac aacaggccat agatgagcca aaaaggacta
     1081 tcgactgtta agctactcat tttaccgtaa gagcgcaaat cgcgtccggg atttttatct
     1141 aagatgatcg gttttttgcg tgatcatggt acgtagccaa gttaaagctg ggtcattttc
     1201 tctgtctcgg tgccagaaca aagtgtaagc cattggcgga aattcgagtg gcagcggcag
     1261 taatgccatg tcgtgttgtt tggctgccag cttcacaaag tggcttggcg cggtaaacac
     1321 aaaatcagtg taagaacaca aactggcggc actgttaaag tccggtacgg tgactgcgat
     1381 gtcacgttcg cgaccaatgt cggctaaacg atagtcgagc agccaacggt cgttgccatc
     1441 acaacgcacc tgaacatggc gcagggctag ataagcttcc aaattccaat taccacgcaa
     1501 agccgggtgg tctttacgta cgatacacat ttggtggtca cgatagattt cctgctcaca
     1561 aatgtcatct ggtggcagca tcgtcagctt ggcgtcgttg atatcgatat ctcgacccgt
     1621 catgcctaaa tcgatttcac cacgctgaat catcttgaag gtttgctccg accaagagtg
     1681 ggtactgatg gtcacgcctg gcgcttgttg gaaaatcgct ggcaagaagt gaggcagaat
     1741 gagcgggtag acactctcta ccgctgcgat ttgaaaacgg tactcactgc tctgtggtga
     1801 gaactcttcg ggttgagtca gcacctcaag ttggtttatc aacagatcca gtttcggttt
     1861 aaggaacaat gcgcgcggtg ttggcgtcaa tccgtgtgag tttcgagtga ataggggatc
     1921 atcaaattgg gtacgtaatt tagccaagga cttactcacg gcggactggc tcaagcacag
     1981 tcggtgagcg gctcgggtga cattcaactc ttcaatcagc actttaaaac acaccagtaa
     2041 attgaggtcg atgcgtgcca gtttctctac gttcacagtg attttcccca ttggaataat
     2101 ggtcatgagt atacatcatt tccattcata tcatcagatg attaagcttt gcgcaaagtt
     2161 cttgttcaat ttggagtgtt ttgtgtctag ccatattaca aatagcaaaa aacagatggc
     2221 gctgttgacc atgttagttc tgttcagtcc gcttgcgatt gatatctatt tacctgcttt
     2281 gccccttatc gcgtccactt ttcaggtaga aaatgcattg gcacaagaca ccatcacttg
     2341 gttcctattt gctatgggtg ttggtcagct attcgctggt cccttggcag ataaactcgg
     2401 acgtcgaact gttgcattgg gaggcatcac catctacgca ttgagcgctt tattggcgtg
     2461 gagtgctcaa aatattgagt ggatgttggc ggctcgcttg ctacaaggct taggtgcatg
     2521 tgcaacatct gtagcagcct ttgcaacagt tcgcgatatc tttggcccgg aaaaaagcgg
     2581 caaaatgatc agctacctta acggtgcgat ctgctttatc ccggcattgg caccgattct
     2641 tggtagttgg ttaacccaac aatttgattg gcgtgcaaac ttcagcttta tggccggttt
     2701 cgctgtgatt gcgggcgcga tgatgttcct tggaatgaag gaaaccaacc cagcaaccga
     2761 aaagcaagcc gtgtttaagc taagccgcta ttggtcggta ctaagtacac cgtcattcat
     2821 tttccatgca tcattgtgct tgatggcgat ggccgtgatt cttgcttacg taacttctgc
     2881 tccaggcgtc ttgattacag gtatgggttt gtcgatgaac gaattcactt tctggtttgg
     2941 ccttaacgcg gtatttaata ttgcggcatg tatgctagcg cctaagttta tggatcgctg
     3001 gggcacacac aactcgcttg tggttggtat cagcttgtta gcaattgctg gtgtgatcat
     3061 gatggtaatg aaagagcaca atacggcgtt ggctttcatg ttgccaattt ttatctcatc
     3121 ggttggcttt gcttggattc ttggtgcggc agcaggtaaa gcactagaac catttggtga
     3181 taaggcgggg accgcggcag cactacttgg cttgttccag atgagtggct ctggtttgtt
     3241 ggtgggtacg ctgcaacgcc tatcacttga accacaaact ctgatcgcga ttcatatgtg
     3301 ggtactgctt ccagcgttgg tgattctgtt tagtaaagca ggtaagagct ggcatgcaaa
     3361 attggcgaat gcataaaact cgacaattta gtattttcca atgtacttaa cgcgtgtata
     3421 tttgtcgttc aaacttttct cgacaccata acggaactca taaagtaatg tcgttaacca
     3481 cgtatgaaat ggctcgtatc ctagagcaaa tggaagagtc accagaaaag gtgatgtttg
     3541 gtaagttgct aaacgaatta ggcaaccaaa gctctgagcg tattcgtagc gcggcaaaac
     3601 aagttcctgt gccagtttta cgtgaccttg tgtatcaatt tcagcaagtg attgagtcac
     3661 gcaaaggtga gcaggttgag cagatggcaa aagaccttgc tcaacaaggt atctcagctg
     3721 aagagctaat ggcttattta aacaaataat aaaaatcccc gcatgatgcg gggatttttt
     3781 tagttggtaa ttttcttttt caggatatgg tcgagagaca atggtcctgg cccccataca
     3841 atcacaacaa gaatcatcaa tccccaaagt tggtgatcat agaaaccttt ctcccacagc
     3901 aatgggtaag agactacagc gatgatgttg aacacaaaca gaatcgcagc catcgggcgg
     3961 gtaatcaatc cgagtgccaa gaacacaggt agaaccaatt ctgcagccgt acctaagtaa
     4021 gccgccaatt cccatggcag tattggcact tggtattcca actcaaataa atacagtgtg
     4081 ctatcccaag acgagagttt gattagccct gaattgaaaa acacccatgc aacccacaag
     4141 cgacaaaaga gaagtagtaa agggacaaag ccagcttgta gggtactgat taaatcgtcg
     4201 taccgattca ctaagttctt aaccgtatcc gtcatagagt gctccttaga ttgatttcaa
     4261 tgtaaagccg tcaacgagat cgagtgccat gatgctattg agatgagcga gtaaaacttc
     4321 aggtatttcg cttaaactca gctgctgctc taaacattgc agcagttgga acacattggc
     4381 atcgagtgcg tgacacaagg cttctccatt ggcttgaatc gagatgacac cttgctgtaa
     4441 ttggttgata ttaagttgtt cgaattgccc agtttgaatc gcgccaaaca aatcaaatac
     4501 ggcgtagcta gagtcaaagc tgcggcagcc ttttttaagg tgcaaaatca aagcgggttg
     4561 ttgctcttca ctcacttctc caagtgccgc aagctgtttt aattctgctg cattggattg
     4621 ttcatactgc gcttgacgag caaggtcgat atgccactcg aagcgagcga cttcagggct
     4681 gtatggtgct tgtgcgatca cctgactgaa ctgcatgatg gtgtcttgaa aaccttcgcc
     4741 ataatgggca acatttcctt cttctaatgg ataagtgaga acatgctggc gagccatctg
     4801 ttcaaagcat tctttaccaa gcagcgcttc aaccatcggg taggtcgcgg ataacacctc
     4861 gcttaagctg acgataaagt tattgcggta aatctgcatg cgttcatcag cggtaaactc
     4921 atcactggca atatcgcaat cttcaccgag tgcttgatag tgtagggctt tagcaaactg
     4981 gctttgtaag gtggctagat tcatgatgcc ttcctcgatt cgctttgttc acttgggatt
     5041 gcgccttgca acagcagttg cgatgctttg tgtgcttctc cgagcaagac ttctggcgca
     5101 gggatatcca agtcccattc aatcaacgta tggcgtggac cgtgtttttt tgtccactgc
     5161 gcgaataact gccaaacttc atcactaact gggcggctat gggtatcaat ccatatctca
     5221 cctttgtcga gttgtttgat ggtaaaacct gccaagtgaa tctcatccac tttgtcggct
     5281 ggaatcgcat ctaggtatgt gtcgcaatca aaaccgtggt tgaacgccga aacataaaca
     5341 ttgtttagat cgagcaataa acgacagtca gtgcgctttt gaacttcggt aagaaattcc
     5401 cattcgctga tggtcgaatg ttgaaacttc acataactag atgggttctc tatcaagatc
     5461 tcacgttgca aataatcttg tacttcattc acgttacgag tgaatacttt gagcgcttct
     5521 tccgtatatg gaagtggaag caggtcatta aagtagtgac cgccgttttc actccaactc
     5581 aaatggtcag aaacaagaat cgggtcgata gcgtcaatca gcgctttaag ttgagcaagg
     5641 tgcttttgat ttacacgttc caccgaacct aatgacagac caatgccgtg gcagctaatt
     5701 tgatactgct cgcgcagcgc gtgcagttga tggcgctctg cagcgttggg ttgaaaatag
     5761 ttttcactgt ggatttctaa ccaagacaac ttgggtttgt tttggctaaa gtaatcgagg
     5821 tgaggggttc ttaatccaac tccaacatgg tcgtggaagg tgtggtgttt cacgtgaaac
     5881 tcctttttca aatcgtgcgg gaagagaaag gtgcgttgct tgagcatcaa cgcaccctcg
     5941 cagcaattag cgatgaaaga ttacgaagaa gaagtgctac cgccagtcag tttgtcacac
     6001 agaccttttg gtacgactac gaatgcgtct ttttggttat cttctttaga agtaccggca
     6061 catgagctgc ttttcgttgc acagtcgttt ttacctgctt tagaaacgcc gtagcacttt
     6121 tctttctcag cagccacagc tggagccgcg gttagcattg tgccgccaag tgctagaagg
     6181 ccagtaacag cagcagtaac agctagattc gactttttca taataaattc ctctgaatga
     6241 tttcctttac tttaagttgg caaggtgaac cgcctgtttt ggcgttttgt tatcagcttg
     6301 cttaatttaa aagataggaa acggactaaa aaactttcat aagtattttc gaaatcaata
     6361 gatttgaaag gtaggtttta tataaaccct tgatgtttag agtgaaaatg caacgatttt
     6421 tttatgaaat tttgtctaat ctgaactggt tgtttaggtt ataatctatt tttatgtata
     6481 aataaccagt agctctcatc atgatggatc catctctatt actcgacggt ttgaacgaca
     6541 aacaacgtga agccgttgca gcacctctag aaaacttgct cgtccttgct ggtgcaggga
     6601 gtggtaagac acgcgttctt gttcaccgta tcgcttggtt gatgtcggtc gagcaatcat
     6661 ctccgttctc aatcatgtcg gtaaccttta ccaataaggc ggcggcagag atgcgtggac
     6721 gtatcgaaga gctaatgatg ggcagtgcag gcggtatgtg gaatggtact ttccacggca
     6781 tttgtcaccg tattctgcgt gcgcactatc ttgatgccaa gctaccggaa gatttccaaa
     6841 tcatcgacag tgacgaccaa cagcgtctac taaagcgttt gatcaaagcg caaaaccttg
     6901 atgagaagca gtggccagca cgccaagtgg catggtggat caacggcaag aaagacgaag
     6961 gtctacgtcc gtcgcatatt gatgcgtacc acgatccagt gaccaagaca tatctgcagc
     7021 tgtacaccgc ttaccaagaa gcgtgtgatc gtgctggttt agtcgatttt gcggaaatct
     7081 tgctgcgcgc acatgagcta ctgcgtgata acaagttcgt tcgtgaacac taccaagcac
     7141 gctttaagca tatcttggtg gacgagttcc aagataccaa caacattcaa tacgcttggc
     7201 tacgtatgat ggcgggtcct gagtgtcacg ttatgatcgt aggtgatgac gaccagtcga
     7261 tttacggctg gcgtggtgca aaagtcgaga acattgagaa atttacgctg gaattcccaa
     7321 gcgtgaatac cattcgtctt gagcaaaact accgttcaac caagaccatt ctggaagcgt
     7381 cgaacgctct gatcgcgaat aacaccgagc gtatgggtaa agagctttgg acagatggcg
     7441 ttgtcggtga gcctatctcg gtatacagcg cttacaacga attggatgaa gcccgttttg
     7501 cggtaaacaa aatcaaagag tggcaagaca aggggggggc tctgaatgac gctgcaatgc
     7561 tttaccgtaa caacgctcag tcgcgtgttc ttgaagaagc cttgattcaa gctggtctgc
     7621 cttaccgtat ctacggcggc atgcgattct tcgaacgtca ggaaatcaaa gatgccttga
     7681 gctacatgcg tctgattgcc aaccgtaatg atgatgcggc gtttgaacgt gtggtgaata
     7741 cgccaacgcg tggtttgggt gataagacgc ttgaaaccat ccgttttgcg gctcgtgacc
     7801 gtggttgcac catgtgggaa gcgagtgtcg ctatgttgga tgagaaggta cttgcaggtc
     7861 gggctgctgg tgctctaagt cgttttatcg agcttgtcac ggcactagaa gacgatacca
     7921 tcgagatgcc gctgcatcac caaactgacc atgtgattaa atactcgggc ttgttcgcca
     7981 tgtacgagca agagaagggc gaaaagtcta aggcgcgtat tgagaacttg gaggaattgg
     8041 tgactgcaac tcgccaattc gagaaaccag aagaagctga ggacatgtca ctgctgacgg
     8101 cattcctaac ccacgcggca ctagaagcgg gcgaaggaca agcggacgag tttgaagatg
     8161 cggttcagct tatgacattg cacagtgcta aaggtctaga gttcccgttg gtgtttatgg
     8221 ttggtgtaga agaaggcatg ttcccaagcc aaatgtcggc agaagaagca gggcgtttag
     8281 aagaagagcg tcgtctgtgt tacgtaggca tgacccgtgc gatgcagaaa ctgtacatca
     8341 cttatgctga aatgcgccgt ttgtacggtc aggataagta ccataaaccg tctcgcttta
     8401 tccgtgaact gccagaaact tgtttggacg aagtacgcat gaaggcgcaa gttagccgtc
     8461 ctgcaagcag cggtcgattt agccaaacgg cggtgaaaga gagctttaat gaaaccggct
     8521 ttacgctagg ttctcgtgtg atgcatccaa agtttggtga aggcaccatc atcaacttcg
     8581 aaggtagtgg tccacagagc cgcgtacaga ttgcctttaa cggtgagggc atcaaatggt
     8641 tggtgactgc ttacgctcga ctagagaaac tgtaaggctt taacaaaact aatcaactta
     8701 agagctgctt cggcggctct ttttgtttgt gctgtttttg tgtcgctaac gcagtaaaaa
     8761 atggaatgat aaatggagtg caaaagcgcg atttaacgat gccgttttaa gtgaaagtag
     8821 ggtgttgtta gtgaatgtct gttttctgca gggctgctga gaaaaatttt aggcaaagaa
     8881 aaaccccgag ggcttgcgcc catcggggtt atagtcttac tcgcagcaat ccggctacta
     8941 agagtgctcc atgcatctaa tccatgatag tgtgctgaat ccgtcagctt aatccttacg
     9001 tcgccttcct agcggtgtcc ttaatgacct tatcctggtc tgctaaccat cctcgttagc
     9061 tctcatcact tgttccctga gcggtgtccc tgacatcatc ctgatgttca aatccttgcc
     9121 tcgtccagag gtgtccattt cccgtcctta gtagcaacca tcctagtcac tattgattcc
     9181 gttcaatgtc caattttgca atccatgccc gactattcat cctgaataac cgtttcttct
     9241 tcctgaagtt caccaagtcc gtggtgtttc ctgttccgtg tcagcatcct tccgacaggt
     9301 ttaatattac gtgtttaacg gtttccaaca acggacaaat ctcacatttt tttactctct
     9361 tagcgtttaa aaaagataca taaccattta aatcaatatc ttatgggttt ttgtgcgtag
     9421 ttttgccatt aaaaaagaga ggtttgctca accctttgtg agagatctcg cacaaagggt
     9481 cgagctaaat gcgcttattg tccgatagcg gcaccttcac gtcttggatc ggccgcacct
     9541 tctaggcctt gttcagttat acgtatagca tgcagtccag agttcaaatc acgaacatcg
     9601 gtcttaaagc ccatcttctc caacgcaggt tgcaagcttt ctgctgcggt accttgctca
     9661 atatctaagg taccaaaacg gttcagcaat cgtggctgat taatcgcgct ctggatgtcc
     9721 atatcccatt gcgtgtgggc gataatggct tgtgcaacgt aaccaatgat gcggctgcca
     9781 cccggtgagc caattgccat gtaaggtttg tcatccttca tcataatggt tggtgccatg
     9841 gatgagcgtg ggcgtttgcc cggttctaag cggttcgcga ttggcacacc accttgatga
     9901 gtgcggaagg agaaatcggt aagttcgtta ttgagcaaga agccgcgcac catcaagcgt
     9961 gagccaaaag cgttttcaat ggttgttgtc attgaaacta cattgccttg cttatcgacg
    10021 atattgaaat ggctggtgga aggcagctcg atcgattggt ccatgcttaa gttcatggcg
    10081 tgcgaccaag gaggattgcc ggcttcaacc ttagtcaacg ctttaccgac ttgaatcagc
    10141 tcagcacgct gttttagata gtctttatca agcaagcctt cggttggcat tggcacataa
    10201 tcttggtctg ccatgtattt accgcgatcc gcgaacgcaa ggcgagacgc gtcggcgatc
    10261 acttgccatg atttcgcgct ttcggctccc caacctttaa gatcgtattg ctcggtgatc
    10321 gcgagaatct gtccaaccgt taatgcgcca gagctaggtg gtcccatgcc gcagatgtca
    10381 tagctttggt aagccgcaca aaccggttca cgttgcttga tttggaaagc atcaaagtca
    10441 ggttgtgcca atacgccagg attgcccggt gcattctgta cagtcttgat gatgtctgtg
    10501 gcgatatcgc cttgatagaa agcttttgcc cctcgctctg caattgccgt cagagtttgt
    10561 gcgtattcag ggtttttcaa caacgtgcct tcggtttttg gtgagccatc tggattgaag
    10621 aagtaagcct tagtcgcagg gaagcgtgat aggcgcttgg catctttctc aatcagactc
    10681 gcgagacgag gactgattga gaaaccttgc tcagccaagg taattacagg ttggatgatt
    10741 ttcttccatt ctaacttgcc gtatttctgg tgcgtgtccc acagtagttt cacagtgcca
    10801 ggagtggcaa cggagcgccc accgacaacc gcatcgtaaa attgcagtgg ttgtcctttg
    10861 tcatctagga agagtttagg cgtcgcggcg agcggtgcgg tctcgcgtcc atcatacgtg
    10921 gttagtt
//
