LOCUS       NZ_CP014035.2          10864 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP014035.2 Vibrio fluvialis strain ATCC 33809 chromosome 2,
            complete sequence.
ACCESSION   NZ_CP014035
VERSION     NZ_CP014035.2
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 16:13:44
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 2634807
            Orig. end    :: 2645671
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10864
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[2639807:2640671](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5864
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10864
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10864
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="5"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(2170..4344)
                     /locus_tag="ctg2_2361"
                     /transl_table=11
                     /translation="MIDPSLLLDGLNDKQREAVAAPLENLLVLAGAGSGKTRVLVHRIA
                     WLMSVEQASPFSIMSVTFTNKAAAEMRGRIEELMMGSSSGMWNGTFHGICHRILRAHYL
                     DAKLPEDFQIIDSDDQQRLLKRLIKAQNLDDKQWPARQVSWWINGKKDEGLRPAHIDAY
                     RDPVTQTYLQLYTAYQDACDRAGLVDFAEILLRALELLRDNKHIREHYQARFKHILVDE
                     FQDTNNIQYAWLRMMAGPQSHVMIVGDDDQSIYGWRGAKVENIEKFTLEFPSVNTIRLE
                     QNYRSTKTILEASNTLIANNTERMGKELWTDGNVGEPISVYSAYNELDEARFVVGKIKE
                     WQDKGGILNDCAILYRNNAQSRVLEEALLQTGLAYRIYGGMRFFERQEIKDALSYLRLM
                     NNRNDDTAFERVVNTPTRGLGDKTLDTVRFAARDRGCTLWEASVQLLDEKVLTGRAASA
                     LSRFVELINALEDDSAEMPLHSQTDHVIKTSGLFDMYQQEKGEKSKARIENLEELVTAT
                     RQFEKPEEADEMTMLTAFLTHAALEAGEGQADEFDDAVQLMTLHSAKGLEFPLVFMVGV
                     EEGMFPSQMSAEEAGRLEEERRLCYVGMTRAMQKLYITYAEMRRLYGQDKYHKPSRFIR
                     ELPETCLDEVRMKAQVSRPASSGRFSQSAVKENFNETGFTLGSRVQHPKFGEGTIINFE
                     GSGPQSRVQVAFNGEGIKWLVTAYAKLEKV"
     aSDomain        complement(2179..4326)
                     /aSDomain="TIGR01075"
                     /aSTool="tigrfam"
                     /description="uvrD: DNA helicase II"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg2_2361_0033"
                     /evalue="0.00E+00"
                     /identifier="TIGR01075"
                     /label="ctg2_2361"
                     /locus_tag="ctg2_2361"
                     /protein_end="722"
                     /protein_start="6"
                     /score="1337.5"
                     /tool="antismash"
                     /translation="LLDGLNDKQREAVAAPLENLLVLAGAGSGKTRVLVHRIAWLMSVE
                     QASPFSIMSVTFTNKAAAEMRGRIEELMMGSSSGMWNGTFHGICHRILRAHYLDAKLPE
                     DFQIIDSDDQQRLLKRLIKAQNLDDKQWPARQVSWWINGKKDEGLRPAHIDAYRDPVTQ
                     TYLQLYTAYQDACDRAGLVDFAEILLRALELLRDNKHIREHYQARFKHILVDEFQDTNN
                     IQYAWLRMMAGPQSHVMIVGDDDQSIYGWRGAKVENIEKFTLEFPSVNTIRLEQNYRST
                     KTILEASNTLIANNTERMGKELWTDGNVGEPISVYSAYNELDEARFVVGKIKEWQDKGG
                     ILNDCAILYRNNAQSRVLEEALLQTGLAYRIYGGMRFFERQEIKDALSYLRLMNNRNDD
                     TAFERVVNTPTRGLGDKTLDTVRFAARDRGCTLWEASVQLLDEKVLTGRAASALSRFVE
                     LINALEDDSAEMPLHSQTDHVIKTSGLFDMYQQEKGEKSKARIENLEELVTATRQFEKP
                     EEADEMTMLTAFLTHAALEAGEGQADEFDDAVQLMTLHSAKGLEFPLVFMVGVEEGMFP
                     SQMSAEEAGRLEEERRLCYVGMTRAMQKLYITYAEMRRLYGQDKYHKPSRFIRELPETC
                     LDEVRMKAQVSRPASSGRFSQSAVKENFNETGFTLGSRVQHPKFGEGTIINFEGSGPQS
                     RVQVAFNGEGIKWLVTAYAKLE"
     PFAM_domain     complement(2494..3513)
                     /aSDomain="UvrD_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13361.8"
                     /description="UvrD-like helicase C-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_2361_0131"
                     /evalue="1.10E-81"
                     /label="ctg2_2361"
                     /locus_tag="ctg2_2361"
                     /protein_end="617"
                     /protein_start="277"
                     /score="275.1"
                     /tool="antismash"
                     /translation="IRLEQNYRSTKTILEASNTLIANNTERMGKELWTDGNVGEPISVY
                     SAYNELDEARFVVGKIKEWQDKGGILNDCAILYRNNAQSRVLEEALLQTGLAYRIYGGM
                     RFFERQEIKDALSYLRLMNNRNDDTAFERVVNTPTRGLGDKTLDTVRFAARDRGCTLWE
                     ASVQLLDEKVLTGRAASALSRFVELINALEDDSAEMPLHSQTDHVIKTSGLFDMYQQEK
                     GEKSKARIENLEELVTATRQFEKPEEADEMTMLTAFLTHAALEAGEGQADEFDDAVQLM
                     TLHSAKGLEFPLVFMVGVEEGMFPSQMSAEEAGRLEEERRLCYVGMTRAMQKLYITYAE
                     "
     PFAM_domain     complement(3529..4314)
                     /aSDomain="UvrD-helicase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00580.23"
                     /description="UvrD/REP helicase N-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_2361_0130"
                     /evalue="5.30E-75"
                     /label="ctg2_2361"
                     /locus_tag="ctg2_2361"
                     /protein_end="272"
                     /protein_start="10"
                     /score="252.9"
                     /tool="antismash"
                     /translation="LNDKQREAVAAPLENLLVLAGAGSGKTRVLVHRIAWLMSVEQASP
                     FSIMSVTFTNKAAAEMRGRIEELMMGSSSGMWNGTFHGICHRILRAHYLDAKLPEDFQI
                     IDSDDQQRLLKRLIKAQNLDDKQWPARQVSWWINGKKDEGLRPAHIDAYRDPVTQTYLQ
                     LYTAYQDACDRAGLVDFAEILLRALELLRDNKHIREHYQARFKHILVDEFQDTNNIQYA
                     WLRMMAGPQSHVMIVGDDDQSIYGWRGAKVENIEKFTLEF"
     CDS             4662..4922
                     /locus_tag="ctg2_2362"
                     /transl_table=11
                     /translation="MKKSNLAVTAAITGLLAMGGTLLTAAPAAAAEKEKCYGVAKAGKN
                     DCATKTSSCAGTSKMDHQKDAFVVVPKGLCDKLAGGSTMDK"
     PFAM_domain     4758..4907
                     /aSDomain="DUF2282"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF10048.11"
                     /description="Predicted integral membrane protein
                     (DUF2282)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_2362_0132"
                     /evalue="3.20E-23"
                     /label="ctg2_2362"
                     /locus_tag="ctg2_2362"
                     /protein_end="82"
                     /protein_start="32"
                     /score="81.6"
                     /tool="antismash"
                     /translation="KEKCYGVAKAGKNDCATKTSSCAGTSKMDHQKDAFVVVPKGLCDK
                     LAGGS"
     CDS             5001..5864
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg2_2363"
                     /sec_met_domain="DUF692 (E-value: 1.5e-88, bitscore: 293.9,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHSTHSHPQVGVGLRSPHMNHFLSQPTPLNWLEIHSENYFQPHAP
                     ARRDLRRLRERYDISCHGIGLSLGSVAAVNAQHLAQLKTLVDDIDPILISDHLSWSENG
                     GHYFNDLLPLPYTEEALAVFCRNVDQVQHALGRPLLIENPSSYLRFSHSTIPEWEFLCA
                     VQQRTDCRLLLDLNNVHVSAFNHGFDSQTYLDAIPASAVEEIHLAGYSVKMLPQGEIWI
                     DTHSRPVSDAVWQLFERWCRQHGTRRTLIEWDLDIPAPEVLLGEAHQAAARLHAIDAER
                     GIRRAS"
     PFAM_domain     5028..5819
                     /aSDomain="DUF692"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05114.15"
                     /description="Protein of unknown function (DUF692)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_2363_0133"
                     /evalue="7.10E-104"
                     /label="ctg2_2363"
                     /locus_tag="ctg2_2363"
                     /protein_end="273"
                     /protein_start="9"
                     /score="346.8"
                     /tool="antismash"
                     /translation="VGVGLRSPHMNHFLSQPTPLNWLEIHSENYFQPHAPARRDLRRLR
                     ERYDISCHGIGLSLGSVAAVNAQHLAQLKTLVDDIDPILISDHLSWSENGGHYFNDLLP
                     LPYTEEALAVFCRNVDQVQHALGRPLLIENPSSYLRFSHSTIPEWEFLCAVQQRTDCRL
                     LLDLNNVHVSAFNHGFDSQTYLDAIPASAVEEIHLAGYSVKMLPQGEIWIDTHSRPVSD
                     AVWQLFERWCRQHGTRRTLIEWDLDIPAPEVLLGEAHQAAAR"
     CDS             5861..6628
                     /locus_tag="ctg2_2364"
                     /transl_table=11
                     /translation="MTLAQLQAQFARGLNYQAGGDECAIIADGLSADERLQIYRNNRVI
                     SLSEVLEATYPMLLAVLGNECFAALAREYVLSHPLTRGDVSHYGEGFAAVIERAQPVMQ
                     AAPYAAALARFEWALDHVQQQYAQAPRNDYQPLSTLSQVAPEQQPQLVFELVPWAAPFC
                     APFALFDLQRAMRDDDFSQLTLNALQSGIIACTADGEPWTQALDEPTYQLLLAMHHRAP
                     LGQIHPDALAALPAIMAMEIVAGFRVAAPNTHD"
     PFAM_domain     5873..6145
                     /aSDomain="DUF2063"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09836.11"
                     /description="Putative DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_2364_0134"
                     /evalue="1.60E-20"
                     /label="ctg2_2364"
                     /locus_tag="ctg2_2364"
                     /protein_end="95"
                     /protein_start="4"
                     /score="73.2"
                     /tool="antismash"
                     /translation="QLQAQFARGLNYQAGGDECAIIADGLSADERLQIYRNNRVISLSE
                     VLEATYPMLLAVLGNECFAALAREYVLSHPLTRGDVSHYGEGFAAV"
     CDS             6644..7102
                     /locus_tag="ctg2_2365"
                     /transl_table=11
                     /translation="MADFMHRYKALCHWLQRDFASLVLLLCRVWAGWVFWQSGLSKIAN
                     WDSTLYLFELEYQVPLLPWQLAAYLATGAELALPLLLIPGLFGRLSALALFAVNAMAVV
                     SYPLLWQQGFTDHQLWGLMLLMVFVWGPGNLSLDNWLSRKWQRVILQN"
     PFAM_domain     6713..6955
                     /aSDomain="DoxX"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07681.14"
                     /description="DoxX"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_2365_0135"
                     /evalue="1.00E-16"
                     /label="ctg2_2365"
                     /locus_tag="ctg2_2365"
                     /protein_end="104"
                     /protein_start="23"
                     /score="61.4"
                     /tool="antismash"
                     /translation="LLLCRVWAGWVFWQSGLSKIANWDSTLYLFELEYQVPLLPWQLAA
                     YLATGAELALPLLLIPGLFGRLSALALFAVNAMAVV"
     CDS             complement(7086..7316)
                     /locus_tag="ctg2_2366"
                     /transl_table=11
                     /translation="MQTTKRAKLWIQTLSVSALLTMAGCAEMKQAGTDVGHATRDAATA
                     IGHATRDTTKAIGHATRDAVNSVKDDLNSAE"
     CDS             complement(7432..9474)
                     /locus_tag="ctg2_2367"
                     /transl_table=11
                     /translation="MSNPLLTFTDLPPFSAIKPEHVKPAVEKAIEDCRARIDAVLVGNA
                     EPSWESVIAPIEEVDDRLSRIWSPVSHMNSVMNSDELRDAYESCLPILSEYSTWVGQHK
                     GLFEAYKAIKASKAFATLSRAQQKTITDGLRDFELSGIGLPAAEQKRYGEISKRMSELG
                     SKFSNNVLDATMGWTKHVTDVNELSGMPESALAAAQAAAEAKGLEGYLLTLDIPSYLPV
                     MTYCDNQALRQELYEAYVTRASDRGPNAGKWDNSEIIAEQLKLRHEISRMLGFNTYSEK
                     SLATKMAESPEQVLGFLNNLAAKAKPQGEREVEELRQFAEQEFGVTALNLWDIAYYSEK
                     QKQHLFDISDEELRPYFPEHKVVSGLFEVLNRVFGMEVKERQGVDTWHESVRFFDIFDS
                     EGTLRGSFYLDLYAREHKRGGAWMDECRVRRINGEGELQTPVAYLTCNFNRPVGNKPAL
                     FTHDEVVTLFHETGHGIHHMLTQVEVGSVSGINGVPWDAVELPSQFLENWCWEEEALAF
                     ISGHYETGEPLPKAMLEKMLAAKNFQSAMFILRQLEFGLFDFTLHTTYDPEQGPKVLET
                     LADVKKKVAVLPSLEWNRFSHSFSHIFAGGYSAGYYSYLWAEVLSADAFSRFEEEGIFN
                     RETGLSFLNNILEMGGSEEPMELFKRFRGREPQIDALLRHAGIAA"
     PFAM_domain     complement(7444..8811)
                     /aSDomain="Peptidase_M3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01432.22"
                     /description="Peptidase family M3"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_2367_0137"
                     /evalue="1.70E-163"
                     /label="ctg2_2367"
                     /locus_tag="ctg2_2367"
                     /protein_end="677"
                     /protein_start="221"
                     /score="545.2"
                     /tool="antismash"
                     /translation="VMTYCDNQALRQELYEAYVTRASDRGPNAGKWDNSEIIAEQLKLR
                     HEISRMLGFNTYSEKSLATKMAESPEQVLGFLNNLAAKAKPQGEREVEELRQFAEQEFG
                     VTALNLWDIAYYSEKQKQHLFDISDEELRPYFPEHKVVSGLFEVLNRVFGMEVKERQGV
                     DTWHESVRFFDIFDSEGTLRGSFYLDLYAREHKRGGAWMDECRVRRINGEGELQTPVAY
                     LTCNFNRPVGNKPALFTHDEVVTLFHETGHGIHHMLTQVEVGSVSGINGVPWDAVELPS
                     QFLENWCWEEEALAFISGHYETGEPLPKAMLEKMLAAKNFQSAMFILRQLEFGLFDFTL
                     HTTYDPEQGPKVLETLADVKKKVAVLPSLEWNRFSHSFSHIFAGGYSAGYYSYLWAEVL
                     SADAFSRFEEEGIFNRETGLSFLNNILEMGGSEEPMELFKRFRGREPQIDALLRHAG"
     PFAM_domain     complement(9037..9354)
                     /aSDomain="TOP_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF19310.1"
                     /description="Neurolysin/Thimet oligopeptidase, N-terminal
                     domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_2367_0136"
                     /evalue="8.30E-28"
                     /label="ctg2_2367"
                     /locus_tag="ctg2_2367"
                     /protein_end="146"
                     /protein_start="40"
                     /score="96.7"
                     /tool="antismash"
                     /translation="LVGNAEPSWESVIAPIEEVDDRLSRIWSPVSHMNSVMNSDELRDA
                     YESCLPILSEYSTWVGQHKGLFEAYKAIKASKAFATLSRAQQKTITDGLRDFELSGIGL
                     PA"
     CDS             9799..10593
                     /locus_tag="ctg2_2368"
                     /transl_table=11
                     /translation="VVKHIVQSLILSSLQQKDKPFVYHDTHSGVGRYDLTHEWSEKTGE
                     YKQGIARLWQQTEVPEDIHSYLDAIKALNDDGELRYYPGSPRVARAHLRSHDRMVLTEL
                     HPSDYPLLEQEFHRDRQVAIFKEDGFARLKGSLPPKERRGLVLIDPPYELAKEYRDVVQ
                     AIAQSYKRWATGIYAIWYPVVNRCDIDDMIEGLQGLGIRKILQIELGVSPDTNERGMTA
                     SGMIVINPPWKLESQMQSILPFLKEAIAPATGHYKVEWIVPE"
     PFAM_domain     9850..10584
                     /aSDomain="RsmJ"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04378.15"
                     /description="Ribosomal RNA large subunit methyltransferase
                     D, RlmJ"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_2368_0138"
                     /evalue="6.80E-120"
                     /label="ctg2_2368"
                     /locus_tag="ctg2_2368"
                     /protein_end="262"
                     /protein_start="17"
                     /score="398.9"
                     /tool="antismash"
                     /translation="DKPFVYHDTHSGVGRYDLTHEWSEKTGEYKQGIARLWQQTEVPED
                     IHSYLDAIKALNDDGELRYYPGSPRVARAHLRSHDRMVLTELHPSDYPLLEQEFHRDRQ
                     VAIFKEDGFARLKGSLPPKERRGLVLIDPPYELAKEYRDVVQAIAQSYKRWATGIYAIW
                     YPVVNRCDIDDMIEGLQGLGIRKILQIELGVSPDTNERGMTASGMIVINPPWKLESQMQ
                     SILPFLKEAIAPATGHYKVEWIV"
ORIGIN
        1 attgggacgc caagcaaaag gcgctcacga cctttgatgg ccgcgaaacc gcgccgctcg
       61 atgcgacgcc gcggctgttt ctcgacagcg ccggccagcc gctgaaattt tacgatgccg
      121 tggtcggtgg ccgctccgtc ggcacgccgg gcaccgtcaa actgctgtgg gagacgcatc
      181 gtctgtacgg caaaatggcc tgggcgcgcc tgattgagcc ggtagtcaaa ctggcacaag
      241 aggggtttga agtcagcccg cgccttgcca cgctgattgc cgacgatcag cagcgtttga
      301 gccgtttccc cgccaccaaa gcctatttct ttcagcccga cggctcgccg ctgaccgcag
      361 gctccgtgct gaaaaacccc gagtacgccg ccacgctgag cgccatcgcc cagcgcggtg
      421 acaaagcgtt ctatcagggc gaaatcgccg aagacatcgt ccacacggtt cagaccgcga
      481 tgggcaaccc gggtgtgctg gcgcagcatg atttcgatgc ttaccaaatc aaacaacgtg
      541 cagccgtgtg cgcgccgtat caaagctatc aggtgtgtgg catggggccg ccaagctccg
      601 gcgcactgac cgtcggccag attctggcac tgaccgagaa atatgacctc aaaggctggg
      661 gtgccagcag cgccaaatcg tggcaggtga ttggcgatgc ctcacgactg gcgtttgccg
      721 accgcggctt gtacatggcc gatcaggatt atgtgccgat gccaacggaa ggactgctcg
      781 atcccgggta tctggcgcag cgcgccaagc tgattcagcc gggcaaagcc ctgaccagcg
      841 ccgaagccgg cacgccacct tggcaacatg cgatgctgca aagccccgat cagtccatcg
      901 aactgccgtc caccagccat ttcaacatcg tcgaccgtga cggtaacgtg gtgtccatca
      961 ccaccaccat cgaaaacgcg ttcggctccc gtctgtttgt acgcggcttt ttgctcaaca
     1021 acgaactgac cgatttctcc tttgcgaccc acgataacgg ccgcccaata gccaaccgtc
     1081 tggagccggg caagcggccg cgttcttcga tggcccccac gattgtgctg cacaacgagc
     1141 aaccttactt agccatcggt tcaccgggtg gcagccgcat catcggctat gtggcgcagg
     1201 cgttgattgc ccatctgcaa tggggcatgg acattcagag cgcgattaac cagccgcatg
     1261 tgctcaaccg ctttggggaa accgatgtcg aacagggcac ccaagcggag cagctcaaac
     1321 cggaactgga gaagatgggc gtgaaagtcg ccgtgcgcga tctcaactcc ggcttgcacg
     1381 cgattcgcat cacagtgcaa ggtctggaag gcgcggcgga tcctcgtcgt gaaggggtcg
     1441 cgatcggcga gtgatcctca cgtaatcgat cgtcccaccg ttttgtaaga gatctcgcac
     1501 aaagcggtgg ggtaatctcg ctttttatct ggcaaaaagg acaacaacaa atcgtaagtg
     1561 gttgttttta aataaactca atgtattaga gcaaaataaa tcgctacgta atcgatttcc
     1621 tcacattgcc ccgcagagcg aaatccgtaa gatgaatcgt gtcggaagga tgctgacacg
     1681 gaacaggaaa tcactacgga ttggtgatct tcaggaagaa gatacggtta ttcaggatga
     1741 atgatcggca aggatagcaa acaggacatt gaacggactc aatcgttacc aggaaggcga
     1801 cgacaaggga atgacaatgg actcctctgg acgaggcaag gactcagcat caggatgatg
     1861 ccaaggacac cgctcaggga acaagtgatg agagctaacc aggatagtta gcagatcagg
     1921 aagatcaagg acaccgctag gatggcgatg aacggattac gctgacggat acagcatact
     1981 tatcaaggaa tagatgcagg gagcacctat tagtagccgg attgctgcga gtaagactat
     2041 aaccccgaag ggctttggcc cctcggggtt tttcttttgc tatcgctcaa aaatggcgtg
     2101 ttatccgtcg gcggcaaacg taaaaaaacc cggtacactg accgggtttt tcgtgactca
     2161 tccgtcgggt cagacttttt ccagcttggc gtaagccgtc accaaccact tgatgccttc
     2221 gccattaaag gcgacctgca cgcggctttg cggaccgctg ccttcaaagt taatgatggt
     2281 gccttcacca aatttcggat gctgcacacg tgagccgagt gtaaagccgg tttcgttgaa
     2341 gttctctttc accgcgctct ggctgaaacg gccgctgctg gccggacggc tgacttgcgc
     2401 tttcatacgc acttcatcga ggcaggtttc cggcaactcg cgaataaagc gcgatggctt
     2461 gtggtatttg tcctgtccgt acagacggcg catttccgca taggtgatgt acagcttctg
     2521 catcgcgcgg gtcatgccca cgtagcacag acggcgctcc tcttcgaggc gccctgcttc
     2581 ttcggccgac atctggctgg ggaacatgcc ctcttccacg cccaccataa acactagcgg
     2641 aaactccaga cctttcgcac tgtgcagcgt cattagctgc acggcatcgt cgaattcatc
     2701 cgcttgccct tcacccgctt ccagtgccgc atgggtcaaa aacgcggtca gcatggtcat
     2761 ttcgtccgct tcttccggct tttcaaactg gcgggtcgca gtgaccagct cttccaagtt
     2821 ttcaatccgc gctttggact tctcgccttt ttcctgctgg tacatatcaa acagacccga
     2881 agtcttgatc acatggtcgg tttggctatg gagcggcatc tcggcgctgt catcttccag
     2941 cgcgttgatc agttcaacaa aacggctcag tgctgaagcc gcgcggcccg tcagcacttt
     3001 ttcgtccagt agctgcacac tggcttccca caaggtgcag ccgcgatcgc gcgccgcaaa
     3061 gcgcacggta tccagcgtct tatcgcccag accacgggtg ggcgtgttga ccacgcgctc
     3121 aaaggcggtg tcgtcgttgc ggttgttcat caggcgcaga tagctcagcg catctttgat
     3181 ttcctgacgt tcgaagaagc gcatgccgcc ataaatgcgg tacgccaatc cggtttgcag
     3241 cagggcttct tccagtaccc gcgactgggc gttgttgcgg tacaaaatcg cgcagtcatt
     3301 gagaatgccg cctttgtcct gccactcttt gattttacct actacaaaac gcgcttcatc
     3361 cagctcgttg tacgccgagt agaccgaaat cggctcgccg acgttgccgt cggtccacag
     3421 ctctttgccc atgcgttcgg tattgttagc gatcagggtg ttggacgctt cgagaatggt
     3481 tttggtcgag cggtagttct gttcaaggcg aatggtgttc acactcggaa attccaaggt
     3541 gaatttctca atgttttcca ctttcgcccc gcgccagccg taaatcgact ggtcgtcatc
     3601 gcccacgatc atcacgtgcg actgcggccc cgccatcatg cgcagccacg cgtattgaat
     3661 gttgttggtg tcctgaaatt cgtctaccag aatgtgctta aagcgcgcct gataatgttc
     3721 gcgaatgtgt ttgttgtcgc gcagcagctc gagcgcgcgc agcagaattt cggcgaaatc
     3781 gaccagaccc gcgcggtcac aggcatcctg atacgcggtg tagagttgca ggtacgtctg
     3841 agtcaccgga tcgcgataag cgtcgatgtg cgccgggcgc aacccttcgt ctttcttgcc
     3901 gttaatccac cacgacacct gacgcgcagg ccactgtttg tcgtccagat tctgcgcttt
     3961 gatcagacgt ttcagcagac gctgctggtc atcgctgtcg atgatctgaa aatcttccgg
     4021 cagtttggca tcaagataat gggcgcgcag aatacggtgg cagatgccat ggaacgtacc
     4081 gttccacatc ccggacgaac tgcccatcat cagttcttca atacggccgc gcatttccgc
     4141 cgccgctttg ttggtaaagg tcacggacat gatggagaac ggcgaggcct gttcaaccga
     4201 catcagccaa gcgatgcggt gcaccagcac ccgggttttg ccactaccgg cccctgccag
     4261 caccaacagg ttttcaagcg gtgccgccac cgcttcgcgt tgtttgtcgt ttaaaccgtc
     4321 aagtaaaaga gagggatcga tcatggctta gctactggtt atttatacat aatttgaacg
     4381 attatacccc taaacgcagc gagacccaag cgagcgaaat ttccctcgga tttcccctct
     4441 cctcgcacaa aacttctgct ctcaggtaaa aaatatcaaa aattttccca cataaaattg
     4501 ttcgataaat catcacctta attataaatt tcatcaatat ttcacttttt cctattttcg
     4561 ttgtgaaagt tttctgcgcg cctgcctctc tttttgggta agcaagccac aacaacggcc
     4621 tgcgacaata acgaccaagg aacagtctcg aggaaatgaa gatgaaaaaa tcaaacctag
     4681 cagtcacagc agcaatcact ggcctactgg caatgggcgg cactctgttg accgcagcgc
     4741 cagccgccgc cgcagagaaa gaaaaatgct acggcgtggc gaaagcgggc aaaaatgact
     4801 gcgcgaccaa aaccagctcc tgcgcaggca cgtcaaaaat ggatcatcag aaagatgcgt
     4861 ttgtcgtggt accaaaaggt ctgtgcgaca aactggctgg cggcagcacc atggacaagt
     4921 aaccacactc tgcgacttga gtgcgcggcg ctggcggcgc actcgattta tctccctgac
     4981 cccgcgataa ggacacgccc atgcactcaa cgcactctca ccctcaggtc ggcgtggggt
     5041 tacgcagccc acacatgaac cattttctca gccaaccgac cccgttgaac tggctggaaa
     5101 ttcacagcga aaactatttt cagcctcacg ccccggctcg acgcgatttg cgccgcctgc
     5161 gtgagcgcta cgacatcagc tgccacggca tcggcttatc actcggttcg gtggccgcgg
     5221 tcaatgcgca acatctggcg cagctcaaaa cgttagtcga tgacatcgac cccatcctga
     5281 tttctgatca cctcagctgg agcgaaaacg gcggccacta ttttaacgac ctgctaccac
     5341 tgccctacac cgaagaagcg ctggcggtgt tctgccgcaa tgtcgatcag gtgcaacacg
     5401 cactgggtcg cccgctgctg attgagaacc cgtccagcta cctgcgtttt tctcactcaa
     5461 ccattccgga gtgggagttt ttgtgcgcgg tgcaacagcg caccgattgc cgtttgctgc
     5521 tcgatctcaa caacgtgcat gtgtccgcgt ttaaccatgg ctttgacagc cagacatatc
     5581 ttgatgccat tcccgccagt gcggtggagg aaattcatct cgcgggttac tccgtcaaaa
     5641 tgctgccgca gggcgaaatc tggattgata cgcacagccg accggtgagc gacgcggtgt
     5701 ggcaactgtt tgaacgctgg tgtcgtcaac acggcacgcg ccgtaccctg attgagtggg
     5761 atctggatat tccagcgcct gaagtcctgc tgggcgaagc gcaccaagcg gccgcacgcc
     5821 tgcatgcgat tgatgccgaa cgcggcataa ggagagcctc atgacgctgg cgcaattgca
     5881 ggcgcagttt gcccgcggcc tcaactatca ggcgggcggc gacgagtgcg cgattatcgc
     5941 ggacggtttg agcgccgatg agcgactgca gatttatcgc aacaaccgtg tgatcagcct
     6001 gagcgaagtg ctcgaagcca cctatcctat gctgctggcg gtgctgggca acgagtgttt
     6061 tgccgcgctg gcacgcgaat acgtgctgtc gcatccgctg acccgtggtg atgtcagcca
     6121 ctatggcgaa gggtttgcgg ctgtgattga acgcgcgcag cccgtgatgc aggccgcgcc
     6181 gtatgccgcg gcactggcgc ggtttgaatg ggcgcttgac cacgtgcagc aacaatacgc
     6241 acaggcaccg cgcaatgact atcagccact cagcacgctg agtcaggtcg cgccggaaca
     6301 gcagccacaa ctggtgtttg agttagtgcc gtgggccgca ccattttgcg caccgtttgc
     6361 gctgtttgat ttgcagcgtg cgatgcggga tgacgacttt agccagctca ctttaaatgc
     6421 gcttcagtcg gggatcatcg cctgcactgc cgatggcgag ccgtggacac aagcgctgga
     6481 tgagccgact tatcagttgt tgctggcgat gcatcatcgc gcgccgttgg ggcagattca
     6541 tccagatgca ctggcggcgt tgcccgccat catggcgatg gagattgtcg ccggctttcg
     6601 tgtagccgcc cccaataccc acgattaaat taaggagccc gacatggctg acttcatgca
     6661 ccgttataaa gccctgtgcc attggctgca acgcgacttc gccagcctgg ttttactgct
     6721 gtgccgcgtc tgggctggct gggtgttctg gcaatcaggg ctgagtaaaa tcgccaactg
     6781 ggacagtacg ctgtacttgt ttgaactgga atatcaggtc ccgctactac cgtggcagct
     6841 cgccgcgtat ctggcaaccg gcgccgaact ggcgctgccg ctgctgttga ttccggggct
     6901 tttcggtcga ctcagcgcac tggccctgtt tgcggtcaat gcgatggcgg tggtgtcgta
     6961 tccgctgttg tggcaacaag gatttaccga ccaccagctg tggggattaa tgttattgat
     7021 ggtgttcgtg tgggggccgg gcaatctgtc gctggataac tggctgagcc gcaagtggca
     7081 gcgcgttatt ctgcagaatt gagatcgtct ttcaccgagt taaccgcatc gcgcgtcgca
     7141 tgcccaatcg ctttggtggt gtcgcgcgtg gcatggccaa tggctgtcgc tgcgtcgcgg
     7201 gtggcgtgac cgacgtcggt gcctgcctgt ttcatctcag cgcagcccgc catcgtcagt
     7261 aacgcactga ccgataacgt ttgaatccac aacttagcgc gttttgtcgt ttgcatggcg
     7321 aatctccaac taatccatag ggtcgcgtaa tatcccttac tctaacaaat aaccccgctc
     7381 aatggagcgg ggttattgtc atgctttggt taactgcgcc aagagagcga ctcaggccgc
     7441 aatgccggcg tggcgcagca gcgcatcgat ctgaggttca cggccgcgga agcgtttgaa
     7501 cagctccatc ggctcttcgc tgccgcccat ttcaagaatg ttattgagga agctcaaacc
     7561 cgtttcgcgg ttgaagatac cctcttcttc aaatcgagag aacgcatcgg ccgacaacac
     7621 ttcagcccac aggtagctgt agtaacccgc gctgtagccg ccagcaaaaa tatggctgaa
     7681 gctgtgcgag aaacgattcc attccaggct tggcagcacc gccactttct tcttcacgtc
     7741 ggcgagcgtt tccagcactt tcgggccttg ttccggatcg tatgtagtgt gcagggtgaa
     7801 atcgaacaag ccgaattcca actgacgcag aataaacatt gcagactgga agttcttcgc
     7861 agccagcatt ttttccagca tcgcttttgg cagcggttca ccggtttcgt agtgaccgga
     7921 gataaacgcc agcgcctctt cttcccagca ccagttttcc aggaactgac ttggcagctc
     7981 gacagcatcc cacggcacac cgttgatgcc agacaccgaa cccacctcaa cttgcgtcaa
     8041 catgtggtga atgccgtggc cggtttcatg gaacagcgtg accacttcat catgggtaaa
     8101 cagcgccggt ttgttgccca ccggacggtt gaagttacag gtcaggtacg cgactggcgt
     8161 ttgcaactcg ccttcaccgt taatgcggcg cacgcggcac tcatccatcc acgcgccgcc
     8221 acgtttgtgc tcacgggcat acaaatcgag gtagaagctg ccacgcagtg tgccttcgct
     8281 gtcgaaaata tcgaagaaac gcaccgattc gtgccaggta tcaacacctt gacgctcttt
     8341 cacttccata ccgaatacgc gattgagtac ttcaaacagg ccactcacca ctttgtgttc
     8401 cgggaagtaa gggcgcagtt cttcgtctga aatatcaaac agatgctgct tttgtttttc
     8461 actgtagtac gcgatgtccc acaggttcag cgccgtcacg ccaaactctt gctcggcgaa
     8521 ctggcgcagc tcttccactt cgcgctcgcc ctgcggcttg gctttggcag cgaggttatt
     8581 caaaaagccc agtacctgct ctggcgattc ggccatttta gtcgccagcg atttttcgct
     8641 gtaggtgtta aaaccgagca tgcgcgagat ttcgtggcgc agtttcaact gctcggcaat
     8701 gatttcgctg ttgtcccact taccggcatt cggaccacga tccgaggcgc gggtcacata
     8761 cgcttcgtac agttcctgac gcagcgcctg gttgtcacag taggtcatca ccggcaggta
     8821 agacggaatg tcgagtgtca gcagataacc ttccagccct ttggcttctg ccgctgcttg
     8881 cgcggccgcc agcgccgatt ccggcatgcc tgacagctca ttcacgtccg tgacgtgttt
     8941 ggtccagccc atggtggcat caagcacgtt gttagagaat ttcgagccca gctccgacat
     9001 gcgtttgctg atttcgccgt agcgtttttg ctctgccgct ggcaggccga tgcccgacaa
     9061 ctcgaaatca cgcaggccgt cggtgatagt tttctgctgc gcgcggctca atgtggcaaa
     9121 cgctttgctg gctttgattg ctttgtaggc ctcaaacagc cctttgtgct gaccgaccca
     9181 cgtgctgtat tccgacaaaa tcggcaggca gctttcgtag gcatcacgca gctcatcgct
     9241 gttcatcacc gagttcatat ggctgaccgg cgaccagata cggcttaagc gatcatccac
     9301 ttcttcaatc ggcgcaatca cgctctccca gctcggctcg gcgttgccta ccagcaccgc
     9361 atcaatgcgc gcgcggcaat cttcaatcgc cttctcaacc gctggcttga cgtgctccgg
     9421 tttaattgca gaaaacggtg gcaaatccgt aaaggtaaga agtggattag acatataacg
     9481 ttccttttaa taaaagagag tacgtgacga accatcacga tacctgaagt catggatgct
     9541 ggcgcaacgc ggcagccggc gcggctaagc acctaaaata attcgatgat ttgctgagcg
     9601 tacgttatca ataagtcact acgccagcaa agaaggatat ggctattacg ttaatagata
     9661 tagtcaggtt cagcaatttt caatactggc gtataatcgg gcgaactgtt ttttgaactg
     9721 accagcacct ggtttcgggt gagagagcgc aatttgttaa gttaccgaca cagtttccat
     9781 gccggaaacc acgcagatgt ggtgaaacac atcgtacaga gcctgatcct gtcttccctg
     9841 cagcagaaag acaaaccctt tgtctaccac gacacgcact cgggtgtcgg ccgctatgat
     9901 ctgacccacg aatggtcaga aaaaaccggt gaatacaagc aaggcatcgc ccgcctgtgg
     9961 caacaaaccg aggttccgga agacattcac agctacctcg atgcgattaa agcgctcaac
    10021 gacgatggcg aactgcgtta ctacccgggt tcaccacgtg tggcgcgtgc gcatctgcgc
    10081 agccatgacc gcatggtgct gacggagctg catccgagcg attacccgct gctggagcag
    10141 gagtttcacc gcgatcgtca ggtggcgatt ttcaaagaag acgggtttgc ccgtctgaaa
    10201 ggcagcctgc cgccgaaaga acgccgtggt ctggtgctga ttgacccacc gtatgagctc
    10261 gccaaagagt atcgtgatgt ggtacaggcg atcgcgcaaa gctacaaacg ttgggcgacc
    10321 ggcatttacg ccatctggta tccggtggtt aaccgctgtg acatcgatga catgattgaa
    10381 ggcctgcaag gtctgggcat tcgcaaaatc ttacaaattg aactcggcgt gtcacccgac
    10441 accaacgagc gcggcatgac cgcctctggc atgattgtca tcaacccgcc gtggaaactg
    10501 gaaagccaga tgcagagcat tctgccgttc ctgaaagaag caattgcgcc agccaccggt
    10561 cactataaag tagaatggat tgttcctgaa taaggtcgcg accgctcaaa attactcagc
    10621 gactgaggat tgtaatttgg caatctaccc caactaacct agattaggtc gttggataca
    10681 tgcataacag aggcttggtg cggacctgtt cgcgatgagc ccaaattgga gaaagtaatg
    10741 gcaacacatt ttgactatat ctgtatcggt ggcggcagcg gcggtatcgc ctcagccaac
    10801 cgtgcagcca tgtacggcgc caaagtcgcc ctgattgaag ccaaagatct tggcggtacc
    10861 tgtg
//
