LOCUS       NC_004603.1            10867 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NC_004603.1 Vibrio parahaemolyticus RIMD 2210633 chromosome 1,
            complete sequence.
ACCESSION   NC_004603
VERSION     NC_004603.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 13:49:51
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 3214140
            Orig. end    :: 3225007
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10867
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[3219140:3220007](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5867
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10867
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10867
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="4"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(2200..4374)
                     /locus_tag="ctg1_2849"
                     /transl_table=11
                     /translation="MMDPSLLLDDLNDKQREAVAAPLENLLVLAGAGSGKTRVLVHRIA
                     WLMSVEQASPFSIMSVTFTNKAAAEMRGRIEELMMGSASGMWNGTFHGICHRILRAHYL
                     DAKLPEDFQIIDSDDQQRLLKRLIKAQNLDEKQWPARQVAWWINGKKDEGLRPAHIDAY
                     HDPVTKTYLQLYTAYQEACDRAGLVDFAEILLRAHELLRDNKFVREHYQARFKHILVDE
                     FQDTNNIQYAWLRMMTGPECHVMIVGDDDQSIYGWRGAKVENIEKFTREFPSVTTIRLE
                     QNYRSTKTILEASNTLIANNTERMGKELWTDGVVGEPISVYSAYNELDEARFAVNKIKE
                     WQDKGGALNDAAMLYRNNAQSRVLEEALIQAGLPYRIYGGMRFFERQEIKDALAYMRLM
                     ANRNDDAAFERVVNTPTRGLGDKTLETIRRAARDRGCTMWEASVAMLDEQVLAGRAAGA
                     LGRFIELITALEDDTLEMPLHEQTDHVIKYSGLFAMYEQEKGEKSKARIENLEELVTAT
                     RQFEKPEEAEEMSLLTAFLTHAALEAGEGQADEFEDAVQLMTLHSAKGLEFPLVFMVGV
                     EEGMFPSQMSAEEAGRLEEERRLCYVGMTRAMQKLYITYAEMRRLYGQDKYHKPSRFIR
                     ELPETCLDEVRMKAQVSRPASSGRFSQTAVKENFNETGFSLGSRVMHPKFGEGTIINFE
                     GSGPQSRVQIAFNGEGIKWLVTAYARLEKL"
     aSDomain        complement(2209..4356)
                     /aSDomain="TIGR01075"
                     /aSTool="tigrfam"
                     /description="uvrD: DNA helicase II"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_2849_0025"
                     /evalue="0.00E+00"
                     /identifier="TIGR01075"
                     /label="ctg1_2849"
                     /locus_tag="ctg1_2849"
                     /protein_end="722"
                     /protein_start="6"
                     /score="1319.8"
                     /tool="antismash"
                     /translation="LLDDLNDKQREAVAAPLENLLVLAGAGSGKTRVLVHRIAWLMSVE
                     QASPFSIMSVTFTNKAAAEMRGRIEELMMGSASGMWNGTFHGICHRILRAHYLDAKLPE
                     DFQIIDSDDQQRLLKRLIKAQNLDEKQWPARQVAWWINGKKDEGLRPAHIDAYHDPVTK
                     TYLQLYTAYQEACDRAGLVDFAEILLRAHELLRDNKFVREHYQARFKHILVDEFQDTNN
                     IQYAWLRMMTGPECHVMIVGDDDQSIYGWRGAKVENIEKFTREFPSVTTIRLEQNYRST
                     KTILEASNTLIANNTERMGKELWTDGVVGEPISVYSAYNELDEARFAVNKIKEWQDKGG
                     ALNDAAMLYRNNAQSRVLEEALIQAGLPYRIYGGMRFFERQEIKDALAYMRLMANRNDD
                     AAFERVVNTPTRGLGDKTLETIRRAARDRGCTMWEASVAMLDEQVLAGRAAGALGRFIE
                     LITALEDDTLEMPLHEQTDHVIKYSGLFAMYEQEKGEKSKARIENLEELVTATRQFEKP
                     EEAEEMSLLTAFLTHAALEAGEGQADEFEDAVQLMTLHSAKGLEFPLVFMVGVEEGMFP
                     SQMSAEEAGRLEEERRLCYVGMTRAMQKLYITYAEMRRLYGQDKYHKPSRFIRELPETC
                     LDEVRMKAQVSRPASSGRFSQTAVKENFNETGFSLGSRVMHPKFGEGTIINFEGSGPQS
                     RVQIAFNGEGIKWLVTAYARLE"
     PFAM_domain     complement(2524..3543)
                     /aSDomain="UvrD_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13361.8"
                     /description="UvrD-like helicase C-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2849_0098"
                     /evalue="3.90E-84"
                     /label="ctg1_2849"
                     /locus_tag="ctg1_2849"
                     /protein_end="617"
                     /protein_start="277"
                     /score="283.2"
                     /tool="antismash"
                     /translation="IRLEQNYRSTKTILEASNTLIANNTERMGKELWTDGVVGEPISVY
                     SAYNELDEARFAVNKIKEWQDKGGALNDAAMLYRNNAQSRVLEEALIQAGLPYRIYGGM
                     RFFERQEIKDALAYMRLMANRNDDAAFERVVNTPTRGLGDKTLETIRRAARDRGCTMWE
                     ASVAMLDEQVLAGRAAGALGRFIELITALEDDTLEMPLHEQTDHVIKYSGLFAMYEQEK
                     GEKSKARIENLEELVTATRQFEKPEEAEEMSLLTAFLTHAALEAGEGQADEFEDAVQLM
                     TLHSAKGLEFPLVFMVGVEEGMFPSQMSAEEAGRLEEERRLCYVGMTRAMQKLYITYAE
                     "
     PFAM_domain     complement(3559..4344)
                     /aSDomain="UvrD-helicase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00580.23"
                     /description="UvrD/REP helicase N-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2849_0097"
                     /evalue="2.90E-75"
                     /label="ctg1_2849"
                     /locus_tag="ctg1_2849"
                     /protein_end="272"
                     /protein_start="10"
                     /score="253.8"
                     /tool="antismash"
                     /translation="LNDKQREAVAAPLENLLVLAGAGSGKTRVLVHRIAWLMSVEQASP
                     FSIMSVTFTNKAAAEMRGRIEELMMGSASGMWNGTFHGICHRILRAHYLDAKLPEDFQI
                     IDSDDQQRLLKRLIKAQNLDEKQWPARQVAWWINGKKDEGLRPAHIDAYHDPVTKTYLQ
                     LYTAYQEACDRAGLVDFAEILLRAHELLRDNKFVREHYQARFKHILVDEFQDTNNIQYA
                     WLRMMTGPECHVMIVGDDDQSIYGWRGAKVENIEKFTREF"
     CDS             4656..4916
                     /locus_tag="ctg1_2850"
                     /transl_table=11
                     /translation="MKKSNLAVTAAVTGLLALGGTLLTATPAVAAEKEKCYGVAKAGKN
                     DCATKNSSCAGTSKQDHQKDAFVVVPKGLCDKLAGGSTSAS"
     PFAM_domain     4752..4901
                     /aSDomain="DUF2282"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF10048.11"
                     /description="Predicted integral membrane protein
                     (DUF2282)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2850_0099"
                     /evalue="8.90E-23"
                     /label="ctg1_2850"
                     /locus_tag="ctg1_2850"
                     /protein_end="82"
                     /protein_start="32"
                     /score="80.2"
                     /tool="antismash"
                     /translation="KEKCYGVAKAGKNDCATKNSSCAGTSKQDHQKDAFVVVPKGLCDK
                     LAGGS"
     CDS             5001..5867
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_2851"
                     /sec_met_domain="DUF692 (E-value: 3.4e-86, bitscore: 286.2,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VKHYDFHPLVGVGLRTPHLDFFQQQRPELSWLEIHSENYFQPNAA
                     ERKYLHTLREQYQISCHGIGLSLGSVERVSQVHLAQLKALIDAIDPMFVSDHLSWSENG
                     GHYFNDLLPLPYTEEALNVFTRNVLEVQDYLQREILIENPSSYVKFQHSTISEWEFLAE
                     VQQRTSCRLLLDLNNVHVSAFNHGFDCNTYLSAIPADKVDEIHLAGFTIKQLDKGEIWI
                     DTHSRPVSTEVWKLYQHWIEQYGPRHTLIEWDLDIPAPEVLLAEAEKASLLLSQITTPL
                     SATRKAS"
     PFAM_domain     5028..5816
                     /aSDomain="DUF692"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05114.15"
                     /description="Protein of unknown function (DUF692)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2851_0100"
                     /evalue="3.20E-104"
                     /label="ctg1_2851"
                     /locus_tag="ctg1_2851"
                     /protein_end="272"
                     /protein_start="9"
                     /score="347.9"
                     /tool="antismash"
                     /translation="VGVGLRTPHLDFFQQQRPELSWLEIHSENYFQPNAAERKYLHTLR
                     EQYQISCHGIGLSLGSVERVSQVHLAQLKALIDAIDPMFVSDHLSWSENGGHYFNDLLP
                     LPYTEEALNVFTRNVLEVQDYLQREILIENPSSYVKFQHSTISEWEFLAEVQQRTSCRL
                     LLDLNNVHVSAFNHGFDCNTYLSAIPADKVDEIHLAGFTIKQLDKGEIWIDTHSRPVST
                     EVWKLYQHWIEQYGPRHTLIEWDLDIPAPEVLLAEAEKASL"
     CDS             5864..6622
                     /locus_tag="ctg1_2852"
                     /transl_table=11
                     /translation="MKLATLQNQFAKALHYQALGDDCDIASDQFTADERMQIYRNNFII
                     SLSEVLSATYPMVEALLGETCFAQIARQHVLTHPLQEGSVIHYGKDFHHTVMLFGQVMA
                     QAPYSPEVALFEWNIDLARQARCEHQADTAVQPLTELPHVPESQHPHLVFHLRPGCKSF
                     DAHYAVFDLFAAVRTQQFDQLNINQLQQGVIRIEPNGEAQCFALAAEAYQLLASLEQKQ
                     CLSDIPEPLLAHLNHIMTLDLIEGFTLQTA"
     PFAM_domain     5879..6142
                     /aSDomain="DUF2063"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09836.11"
                     /description="Putative DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2852_0101"
                     /evalue="5.30E-22"
                     /label="ctg1_2852"
                     /locus_tag="ctg1_2852"
                     /protein_end="93"
                     /protein_start="5"
                     /score="78.0"
                     /tool="antismash"
                     /translation="LQNQFAKALHYQALGDDCDIASDQFTADERMQIYRNNFIISLSEV
                     LSATYPMVEALLGETCFAQIARQHVLTHPLQEGSVIHYGKDFH"
     CDS             6633..7088
                     /locus_tag="ctg1_2853"
                     /transl_table=11
                     /translation="MTDSVKSLISRYDEYTNSLQTHAMPLLLLFCRLWVAWVFFNSGLI
                     KIASWDSTLYLFEFEYQVPLLPWEFAAYSGTFAELVLPVFLALGLFTRPMAAMLFVFNI
                     IAVLSYPLLWEKGFHDHQLWGLMILIVTLWGAGPFSLDRLLKDKFVR"
     PFAM_domain     6711..6956
                     /aSDomain="DoxX"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07681.14"
                     /description="DoxX"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2853_0102"
                     /evalue="1.20E-17"
                     /label="ctg1_2853"
                     /locus_tag="ctg1_2853"
                     /protein_end="108"
                     /protein_start="26"
                     /score="64.4"
                     /tool="antismash"
                     /translation="LLLFCRLWVAWVFFNSGLIKIASWDSTLYLFEFEYQVPLLPWEFA
                     AYSGTFAELVLPVFLALGLFTRPMAAMLFVFNIIAVL"
     CDS             complement(7118..7402)
                     /locus_tag="ctg1_2854"
                     /transl_table=11
                     /translation="MSLTTYEMARILEQMEESPEKVMFGKLLNELGNQSSERIRSAAKQ
                     VPLPILRDIVYQFQQVIESRKGEQVELLAKDLAQQGISADELLAYLNKQ"
     CDS             complement(7494..8765)
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 91.3; E-value:
                     7.6e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_2855"
                     /transl_table=11
                     /translation="MIIHHFHSYHQMIKLSAKFLFNLECCVSSHISNSKKQMALLTLLV
                     LFSPLAIDIYLPALPLIASTFQVDNALAQDTITWFLFAMGVGQLFAGPLADKLGRRTVA
                     LGGITIYAMSALLAWSAQNIEWMLMSRLLQGLGACATSVAAFATVRDIFGPEKSGKMIS
                     YLNGAICFIPALAPILGSWLTQQFDWRANFSFMAGFAVVSGTLMFLMMKETNPATEKQA
                     VFKVSRYWSVLSTPSFIFHASLCLMAMAVILAYVTSAPSVLMTGMGLSMNEFTFWFGIN
                     AVINIAGCMLAPKFMERFGTHNTLVVGISTLALAGVVMLVMNGQNTALSFMLPIFMSSV
                     GFALILGGAAGKALEPFGDKAGTAAALLGLFQMSGSGLLVGTLQRLPFDPQTLIAIHMW
                     VLLPALVILFSKAGKSWHARFANA"
     aSDomain        complement(7545..8663)
                     /aSDomain="TIGR00710"
                     /aSTool="tigrfam"
                     /description="efflux_Bcr_CflA: drug resistance transporter,
                     Bcr/CflA subfamily"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_2855_0026"
                     /evalue="4.40E-70"
                     /identifier="TIGR00710"
                     /label="ctg1_2855"
                     /locus_tag="ctg1_2855"
                     /protein_end="407"
                     /protein_start="34"
                     /score="235.0"
                     /tool="antismash"
                     /translation="KKQMALLTLLVLFSPLAIDIYLPALPLIASTFQVDNALAQDTITW
                     FLFAMGVGQLFAGPLADKLGRRTVALGGITIYAMSALLAWSAQNIEWMLMSRLLQGLGA
                     CATSVAAFATVRDIFGPEKSGKMISYLNGAICFIPALAPILGSWLTQQFDWRANFSFMA
                     GFAVVSGTLMFLMMKETNPATEKQAVFKVSRYWSVLSTPSFIFHASLCLMAMAVILAYV
                     TSAPSVLMTGMGLSMNEFTFWFGINAVINIAGCMLAPKFMERFGTHNTLVVGISTLALA
                     GVVMLVMNGQNTALSFMLPIFMSSVGFALILGGAAGKALEPFGDKAGTAAALLGLFQMS
                     GSGLLVGTLQRLPFDPQTLIAIHMWVLLPALVI"
     PFAM_domain     complement(7632..8642)
                     /aSDomain="MFS_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07690.18"
                     /description="Major Facilitator Superfamily"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2855_0103"
                     /evalue="2.10E-46"
                     /label="ctg1_2855"
                     /locus_tag="ctg1_2855"
                     /protein_end="378"
                     /protein_start="41"
                     /score="158.6"
                     /tool="antismash"
                     /translation="TLLVLFSPLAIDIYLPALPLIASTFQVDNALAQDTITWFLFAMGV
                     GQLFAGPLADKLGRRTVALGGITIYAMSALLAWSAQNIEWMLMSRLLQGLGACATSVAA
                     FATVRDIFGPEKSGKMISYLNGAICFIPALAPILGSWLTQQFDWRANFSFMAGFAVVSG
                     TLMFLMMKETNPATEKQAVFKVSRYWSVLSTPSFIFHASLCLMAMAVILAYVTSAPSVL
                     MTGMGLSMNEFTFWFGINAVINIAGCMLAPKFMERFGTHNTLVVGISTLALAGVVMLVM
                     NGQNTALSFMLPIFMSSVGFALILGGAAGKALEPFGDKAGTAAALLGLFQMSGSGL"
     CDS             8794..9735
                     /gene_functions="regulatory (smcogs) SMCOG1125:LysR family
                     transcriptional regulator (Score: 263.5; E-value: 4.1e-80)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_2856"
                     /transl_table=11
                     /translation="VNIEKLARLDLNLLVCFKVLIEELNVTRAAHRLCLSQSAVSKSLA
                     KLRIQFDDPLFTRNSHGLTPTPRALFLKPKLDLLINQLEVLTQPEEFSPQSSEYRFQIA
                     AVESVYPLILPHFLPAIFQQAPGVTISTHPWSDNTFKMLQRGELDLGLTGKDIDINDAK
                     LTLLPPDDICELEIYRDHQMCIIRKNHPALKQKWNLEAYLALRHVQVRCDGNDRWLLDY
                     RLADIGAERDIAVTVPDFNSAASLCSYTDFIFTAPSHFVQLAAKQLDLVVLPLPLEFPP
                     MAYTLFWHRDRENDPALNWLRTMITQKTDHLR"
     PFAM_domain     8824..9000
                     /aSDomain="HTH_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00126.29"
                     /description="Bacterial regulatory helix-turn-helix
                     protein, lysR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2856_0104"
                     /evalue="1.80E-15"
                     /label="ctg1_2856"
                     /locus_tag="ctg1_2856"
                     /protein_end="69"
                     /protein_start="10"
                     /score="56.7"
                     /tool="antismash"
                     /translation="LNLLVCFKVLIEELNVTRAAHRLCLSQSAVSKSLAKLRIQFDDPL
                     FTRNSHGLTPTPRA"
     PFAM_domain     9079..9717
                     /aSDomain="LysR_substrate"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03466.22"
                     /description="LysR substrate binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2856_0105"
                     /evalue="3.00E-30"
                     /label="ctg1_2856"
                     /locus_tag="ctg1_2856"
                     /protein_end="308"
                     /protein_start="95"
                     /score="105.3"
                     /tool="antismash"
                     /translation="SSEYRFQIAAVESVYPLILPHFLPAIFQQAPGVTISTHPWSDNTF
                     KMLQRGELDLGLTGKDIDINDAKLTLLPPDDICELEIYRDHQMCIIRKNHPALKQKWNL
                     EAYLALRHVQVRCDGNDRWLLDYRLADIGAERDIAVTVPDFNSAASLCSYTDFIFTAPS
                     HFVQLAAKQLDLVVLPLPLEFPPMAYTLFWHRDRENDPALNWLRTMITQK"
ORIGIN
        1 ccttgccgca accccaacac tgtttttgga cgaccaaggc caaccgctgc aattttatga
       61 tgcggttgtg ggcggacgat ctgtcgcgac gccgggcacc gtcaaactgt tgtgggatac
      121 ccaccaaaaa tacggcaagc tggaatggaa aaagatcatt cagccagtga tcaacttggc
      181 tgaggaaggt tttgccgtca gtcctcgtct cgccagtttg attgccaacg acgccgagcg
      241 tttatcacgt tttccgacca caaaagcgta tttctttaac gccgatggct caccaaaatc
      301 cgaaggcaca cgattaaaga atccagaata cgcgcaaacc ttgaaagcca ttgccaggca
      361 aggtgctcaa gccttctatc aaggtgatat tgccaaagac attatcgcaa ccgtgcaaac
      421 tgcagtgggt aacccgggcg tattggcaca acgagatttt gatacttacc gcatcaaaca
      481 gagagagccc gtttgtgcgg cttatcaaag ctacgacatc tgtggtatgg ggccaccaag
      541 ctcaggcgcg ctaactgtcg ggcagatctt ggctatcacc gagcaatacg atctcaaagg
      601 ctggggacca gacagcacca aatcttggca ggtcattgcg gacgcatctg gtctcgcgtt
      661 tgctgatcgc ggtaagtaca tggccgatca agactatgta cccatgccaa ccgaaggttt
      721 gttggacaaa gactatctca aacaacgtgc cgaactgatt caggtcggca aagcactgac
      781 gaaagtggaa gccggtaacc caccgtggtc acatgcaatg aatctcagta tggatgaatc
      841 gatagaactt ccttccacca gccatttcaa catcgtcgat aagcaaggca atgtggtttc
      901 aatgaccacc accatcgaga acgcctttgg ctcgcgctta atggttcgcg gcttcctgct
      961 caataacgag ctaacagact tttctttccg cactcatcaa aatggcgtgc caatcgccaa
     1021 ccgattagaa ccgggcaaac gtccgcgctc ctccatggca ccgaccatca tcatgaaaga
     1081 taatcaacca tacatggcaa ttggttctcc gggtggcagt cgcattatcg gctacgtggc
     1141 acaagccatc attgctcata ctcaatggga catggacatt cagcaagcga tcaaccaacc
     1201 aagagtgtta aaccgttttg gcactgtcga cctcgagcaa gatagcgcag caactcagtt
     1261 gcaaccggca ctcgaaaaga tgggctttaa gaccgaaatt cgcgatttga attccggttt
     1321 acacgccatt cgcatcactg taaatggctt agaaggtgct gccgatccgc gtcgagaagg
     1381 tgcagccatc ggaaaatagt agcctttcgc tcgacccttt gtgcgagatc tctcacaaag
     1441 ggttgggtaa aactctcttt tttagcagta aaagcacccc aaacaacaca taagctattg
     1501 aataatataa atacgtgcag tttttaaacg tttgcgaaat aaaaaaatgt gaacttgcac
     1561 cgttgttgga tagcgccaaa aacgtaatat taaacctgtc ggaaggatgc tgacacggaa
     1621 caggaaacac cacggatttg gtgaacttca ggaagaagaa acggttattc aggatgaata
     1681 gtcgggcatg gaatgcaaaa ctggacattg aacggaatca atagcggcta ggatggttgc
     1741 tactaaggac gggaaatgga cacctctgga cgaggcaagg actgaacatc aggatgatgt
     1801 catggacacc gctcagggaa caagtgatga gagctaacga ggatagttag cagaccagga
     1861 taaggtcatc aaggacaccg ctaggaaggc gacgaaagga ttaagctgaa ggaatacagc
     1921 acgctatcaa ggattcgatg caaggagcac tttttagtag ctggattgct gcgagtaaga
     1981 ctataacccc gatgggcgca agccctcggg gtttttcttt ttctgccatt tccgcccgac
     2041 ctgccaagca cagttgtccc catctcaaac tcaaactcaa actcaaactc aaactcaaac
     2101 tcaaataagg tactttgtag gctccagata caacaagagc cgccgaagca gcccttgagt
     2161 tagtttgcga acaatgcaag ctagctttcg ataaaaacct tacagttttt ctagtctagc
     2221 gtaagcagtc actaaccatt taatgccttc accattgaac gcgatttgaa cgcgactctg
     2281 tggaccgctg ccttcaaagt taatgatggt gccttcgcca aactttggat gcattacgcg
     2341 tgaaccaagt gaaaagcccg tctcgttgaa gttctctttc accgcagttt ggctaaagcg
     2401 accactactt gcaggtcggc tgacttgcgc tttcatccgc acttcgtcca ggcacgtttc
     2461 cggcaactca cgaataaaac gcgatggctt atggtactta tcttgaccat acaaacggcg
     2521 catttccgca taagtgatgt agagtttttg catcgcgcgc gtcataccga cgtagcacag
     2581 gcggcgctct tcctctaaac gcccagcctc ttccgccgac atctggcttg ggaacatgcc
     2641 ttcttcaacg cccaccataa acaccaatgg gaattccaag ccttttgcac tatgcagtgt
     2701 catcaattga actgcatctt caaattcgtc ggcttgccct tcacccgctt ctagcgccgc
     2761 atgagtcaag aacgcagtca gcagcgacat ctcttccgct tcttctggct tctcgaattg
     2821 acgagttgcg gtcaccaatt cctccaagtt ctcaatacga gccttagact tttcgccctt
     2881 ctcttgctca tacatggcaa acaagccaga gtacttgatc acatggtctg tttgctcgtg
     2941 caacggcatc tctaacgtgt cgtcttcgag tgcggtaata agttcgataa agcgacctaa
     3001 tgcccccgcc gctcgacccg cgagcacttg ttcatccaac atcgcaacgc tggcttccca
     3061 catcgtgcaa ccacgatcac gcgccgcacg gcgaatggtt tctagtgtct tgtcacctaa
     3121 accacgagtt ggcgtattca ccacacgttc aaatgcagca tcatcattgc ggttagccat
     3181 caaacgcatg taggcaagtg cgtctttgat ttcctgacgc tcgaagaatc gcataccacc
     3241 ataaatacgg tatggtagac cagcttgaat caacgcttct tccagtacac gggactgggc
     3301 gttgttgcgg tacaacatcg ctgcatcatt caatgctcca cctttgtctt gccactcttt
     3361 gattttgtta accgcaaaac gggcttcgtc caactcgttg taagcactgt aaaccgaaat
     3421 cggttcacca acgacgccgt cagtccacag ctctttaccc atacgctcag tgttattggc
     3481 gatcaaggta ttggaagctt ccaaaatggt cttggtggaa cggtaattct gctctaggcg
     3541 aatggtggtt acgcttggga attcacgggt gaatttctca atgttttcga cttttgctcc
     3601 gcgccaaccg taaatcgact ggtcatcgtc acccacgatc atcacatgac actcaggccc
     3661 cgtcatcatg cgtagccaag cgtattggat attgttggtg tcttggaact cgtcaaccag
     3721 aatgtgttta aagcgtgcct ggtagtgctc tcggacaaac ttgttatcgc gcagtagctc
     3781 atgagcgcga agcagaattt ctgcaaagtc gaccaaacct gcacggtcac acgcttcttg
     3841 ataagcggtg tatagctgca agtaggtttt ggtcacagga tcgtggtaag catcgatatg
     3901 tgctgggcgc aggccttcgt cttttttgcc gttaatccac caagccactt ggcgtgcagg
     3961 ccactgcttt tcatccagat tttgtgcttt gatcagacgc ttcagtaaac gttgttgatc
     4021 gtcgctgtcg atgatttgaa aatcttccgg tagcttggca tcaagatagt gcgcgcgcaa
     4081 aatgcggtga caaataccgt gaaaggtacc attccacatg cctgacgcac tgcccatcat
     4141 caactcttca atacggccac gcatctccgc tgccgctttg ttggtaaagg ttaccgacat
     4201 gattgagaat ggagacgctt gttctaccga catcaaccaa gcgatacggt gaacaagaac
     4261 acgagtctta ccactccctg caccagcaag gacgagcaag ttttctagag gtgcagcaac
     4321 ggcttcacgt tgtttatcgt tcaaatcgtc gagtaataga gatggatcca tcatgatgag
     4381 ctactggtta tttatacata aaaatagatt ataacctaaa caactagggt gtgttgagac
     4441 aaaactagat aaaaagttcg acgatttttt actcatccat tcaatcagtt atgtaaatca
     4501 aaccatcaaa aagcattctc caaaacaatt tccctgaaag tttttcactc accttcctat
     4561 ctcttaagtt aagcaagcgg acaaaaactg tgcatctcaa tcgctcgtct gcttgcccat
     4621 ctcaacgtaa aggaaatcat tcagaggaaa ttattatgaa aaaatcgaat cttgctgtta
     4681 ctgctgcggt tactggtcta ctagcccttg gtggcactct actaacagca acacctgctg
     4741 tcgcggcaga aaaagaaaag tgctacggcg tggcaaaagc gggaaaaaat gactgtgcga
     4801 cgaagaacag ctcttgcgcc ggcacgtcaa aacaagacca ccagaaagac gcatttgtgg
     4861 tggttccaaa aggtctttgc gacaaattgg ctggcggcag caccagcgca tcttaatttc
     4921 tccgttaatt gttgtgggcg tgtgatggct caactcacac cccacaacct cttctcatcc
     4981 agttcgaaaa ggagtttcac gtgaaacact acgattttca ccctcttgtt ggcgttggtt
     5041 tacggactcc tcatttggac ttttttcagc aacaacgccc agaactgtct tggttagaaa
     5101 ttcacagcga gaactacttt caacccaatg cagccgaacg aaaatatcta cacactttgc
     5161 gagagcaata ccagatcagc tgccacggaa ttggtttatc gttaggctct gttgaacgcg
     5221 ttagccaagt acacctcgct caactgaaag cgttgattga tgccattgac ccgatgtttg
     5281 tctctgacca tttgagctgg agtgaaaatg gtgggcacta ttttaacgac ttgcttcccc
     5341 taccatacac cgaagaagca ctgaacgttt ttactcgcaa tgtgcttgaa gttcaggatt
     5401 atctgcaacg cgaaatctta attgagaacc catcgagcta tgtgaagttt caacactcga
     5461 cgatcagcga gtgggagttt ctcgctgagg ttcagcagcg cacaagttgc cggttactgc
     5521 tcgatctgaa taacgtacac gtatcagcct tcaatcacgg ctttgattgc aatacctatc
     5581 tgtccgccat tccggcagac aaagtggatg aaattcattt ggcgggtttc accatcaaac
     5641 aactcgataa aggcgaaatt tggattgata ctcacagccg tcccgtcagc acggaagtct
     5701 ggaagttata tcaacattgg attgaacagt atggtccgcg ccatacctta attgaatggg
     5761 acttagatat cccagcaccg gaagtgttat tggcagaagc ggaaaaggcc tcgctccttc
     5821 tctcccaaat taccaccccg cttagcgcta cgaggaaagc ctcatgaagc tagccacctt
     5881 acaaaaccag tttgcgaaag cgcttcacta tcaggcattg ggcgatgact gtgatattgc
     5941 gagcgatcag tttaccgctg acgagcgcat gcagatatat cgcaacaact ttatcatcag
     6001 cttgagcgaa gtcctttctg ctacttatcc gatggttgaa gcattactag gggaaacgtg
     6061 ctttgcccaa atagcacgcc aacatgtttt aacgcaccca ctccaagaag gcagtgttat
     6121 tcactacgga aaagactttc accacactgt gatgctgttt ggtcaggtca tggctcaagc
     6181 gccatacagc ccagaagtcg cactctttga gtggaacatc gaccttgctc gccaagctcg
     6241 ttgtgagcat caagcagaca ctgccgtgca accactgact gagttaccac acgtaccaga
     6301 gtcgcaacat ccccatttag ttttccacct tcgccctggg tgtaagagct ttgatgctca
     6361 ttacgcggtg tttgatttat tcgcagctgt tcgtactcag caattcgatc agctcaacat
     6421 caaccaatta caacaagggg tgatccgcat cgagcccaat ggtgaagcgc agtgtttcgc
     6481 gctagctgcc gaagcctatc aattgcttgc cagcttggaa caaaagcaat gtttgagcga
     6541 tatccccgag ccgttgctcg ctcatcttaa tcacatcatg acgcttgacc tgattgaagg
     6601 ttttacgctg caaaccgcgt aaggaggata cgatgacaga ttctgttaaa agcctgatta
     6661 gccgctacga cgaatacacc aacagcttac aaactcacgc aatgccgttg ttgctgctgt
     6721 tttgccgttt atgggtcgct tgggtgtttt ttaattctgg ccttatcaaa attgcctcat
     6781 gggatagcac cttgtacttg ttcgaatttg agtatcaagt tccgttgcta ccttgggaat
     6841 ttgccgccta ttcaggcaca ttcgcagagt tagttcttcc ggtcttttta gcgcttggat
     6901 tatttactcg ccctatggct gccatgttgt ttgtattcaa cattatcgct gtcctgtcct
     6961 acccactact ttgggagaaa ggtttccatg accaccaact ctgggggtta atgattttga
     7021 ttgtgacgct gtggggagcc ggtccgtttt cgctcgaccg attgctaaaa gacaaattcg
     7081 tcagatagaa aaatccccgc gattgcgggg atttctttta ttgcttgttt agataagcca
     7141 gcagttcatc cgctgagata ccttgttgtg cgaggtcttt tgctaatagc tcaacttgct
     7201 cgcccttgcg tgactcaatc acttgttgaa attggtacac aatgtcacgc aagattggta
     7261 gaggtacttg ttttgccgca ctacgaatgc gctcggagct ttgattgccc agctcattaa
     7321 gcaacttacc aaacatcacc ttttctggtg attcttccat ttgctctaaa atacgagcca
     7381 tttcatacgt ggttaacgac attacttttt gaattccatt atggtgtcag gaaaagtgtg
     7441 aacgacaaat atacacgcgt tacatacatt ggaaaatact aaattacact gatttacgca
     7501 ttagcgaagc gtgcgtgcca gctcttacca gcctttgaaa atagaatcac caatgccggt
     7561 agcaataccc acatatgaat agcaatcaat gtttgtggat caaacggcaa acgctgtaag
     7621 gtacccacta acaaaccaga accgctcatt tggaacaaac caagtagcgc cgcggctgtg
     7681 cccgctttat caccgaatgg ttccaacgcc ttgcccgcgg cgccgccaag aatcaaagca
     7741 aaaccaacgg acgacataaa gattggcagc atgaacgaca gcgccgtgtt ttggccattc
     7801 atcaccagca tcaccacacc agccagagcc aacgtcgaga taccaaccac aagcgtgttg
     7861 tgtgtgccaa aacgttccat gaacttcggt gccaacatac agccagcgat gttgatgacc
     7921 gcgttaatgc caaaccagaa tgtgaactca ttcattgaaa ggcccatgcc tgtcatcaat
     7981 accgacggtg ctgacgtcac gtaagctaag ataaccgcca tagccatcaa acatagtgac
     8041 gcgtggaaaa tgaaagatgg cgtgctcagt accgaccagt aacgacttac cttgaatacc
     8101 gcttgtttct ctgttgcagg gttggtttcc ttcatcatca agaacatcaa cgttcctgag
     8161 acaaccgcaa aaccagccat aaagctgaag tttgcacgcc aatcgaattg ctgtgttaac
     8221 cagctaccta agattggggc cagtgccgga ataaagcaga tcgcaccatt aaggtagctg
     8281 atcatcttgc cgcttttctc tgggccgaaa atatcgcgaa ctgttgcaaa ggctgctacc
     8341 gatgtcgcac acgcacctaa gccttgtagc aaacgagaca tcaacatcca ctctatattt
     8401 tgagcactcc acgccaataa agcgctcatt gcgtagatag tgatgccgcc caatgcaaca
     8461 gttcgacgtc cgagtttatc tgccaaaggg ccagcaaaca gttggccaac acccatagca
     8521 aataggaacc atgtaatcgt gtcttgtgct agcgcattgt ctacctgaaa agttgaagcg
     8581 ataagaggta acgcaggtag atagatatca atcgcaagcg gactgaaaag aaccaaaagg
     8641 gtcaacaacg ccatttgttt tttactatta gaaatatggc tagacacaca acactccaaa
     8701 ttgaacaaga actttgcaga gagcttaatc atctgatgat atgaatggaa atgatgtata
     8761 atcatgacca ttattcccca gaggaaattc accgtgaaca tagaaaagct cgctcgtctc
     8821 gacctgaact tactggtctg ttttaaagtg ttaattgaag agcttaacgt gactcgagca
     8881 gcgcatcgac tgtgccttag ccaatccgcg gtgagcaaat cattagccaa acttcgcatt
     8941 caatttgatg atccattgtt tacgcgtaac tcacatggat taacaccaac accacgtgca
     9001 ttgttcctca aaccgaaact ggatctgttg attaaccaat tagaagtgct gacccagcca
     9061 gaagagtttt cgccccaaag cagtgaatac cgttttcaaa ttgcagcggt ggaaagtgtc
     9121 tacccattaa tcttgccgca tttcttacca gcgatttttc aacaggcgcc cggcgtcacc
     9181 atcagtacgc atccttggtc agataacacc ttcaaaatgt tgcagcgtgg tgagttggac
     9241 ttgggattaa ctggtaaaga catcgacatc aatgacgcaa aacttaccct actgccaccg
     9301 gatgatattt gcgaactcga aatctatcgc gaccatcaga tgtgcatcat tcgtaaaaac
     9361 catcccgcac taaaacagaa atggaacctc gaagcgtatc tcgcacttcg tcacgtacaa
     9421 gtgcgatgtg atggaaacga ccgttggttg ttggactatc gtttagcgga cattggcgca
     9481 gagcgcgata ttgcagtcac cgttccagat ttcaatagtg ccgccagctt gtgttcttac
     9541 accgacttca tctttaccgc gccgagccat tttgtgcaac tggctgccaa acagctcgac
     9601 ttggtggtct tgccattgcc gcttgaattc ccgcccatgg cttacactct gttttggcac
     9661 agagacagag aaaacgaccc agccttgaat tggctgcgca cgatgatcac gcaaaaaacc
     9721 gatcacctta gataaaaatg tcggacgcaa tttgcgctta gcggttaaaa tgagtagctt
     9781 aacagtcgat agtccttttt ggctcatcta tggcctgttg tacccagact taaacgtcat
     9841 cttgctacgg cgtttaactc aatcactgca cgaagcagaa ggaaacagct cccacacctg
     9901 agcatgaagg agcggtaatt tgaaggaata aaacagatgc acaacgacac cctaagccgc
     9961 gtgaacgcaa ttcgcgaatg gcttgctcaa cacaacattg atgccctact gatccctcat
    10021 gaagatgaat acctgggtga atatgtccct gcgcacaatg aacgcctcca ttggctaacc
    10081 ggattcacag gctccgcagg cgcagccgtg atcacacaag acaaagccgc gatttttgtt
    10141 gatggtcgct acacagttca agtgaccaaa caagttccta gcgatttgtt tgaatatcgc
    10201 cacctaattg aagaaccggc attggattgg attcaagaca atctaaccgc aaatgcgtcc
    10261 gtggctatcg acccacgcat gcacagttcg gcttggctag atatggcaca agcaaaactg
    10321 gccggaaaac ttgagctaaa cattctctcc agcaacccaa ttgatgaatt gtggcatgac
    10381 cgccctgcac cagtggtttc tgacgttcgc ctcatgccaa caaaagccgt tggtcaatca
    10441 agcgaaagta agcgtaaaga gatcgctcaa ctggtagcaa aagccggtgc agacagcgca
    10501 gtcatcacag cgcttgattc tatttgttgg ctattgaatg tacgtggctt ggatgtatcg
    10561 cgtttgccag ttttactctc gcacgcgatt cttcatgccg actcaagtgt agagtacttc
    10621 ctagatcccg ctcgcttacc tgctgaattt gcagcgcatg tgggtactgg tgtgacggtt
    10681 catcatccag aagcacttca atctcgcctt gaagccatgt ctggtaaaaa ggtattgctc
    10741 gacccagcaa tcagtaacgc atggtttaag ttagttctgc aaaatgcagg cgcatcggtt
    10801 attgctgcag ccgatccatg tttaatgcca aaagccgcga aaaacgaagt tgagattgcg
    10861 ggcatga
//
