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Overview
1.1
1.2
1.3
1.4
2.1

### Identified secondary metabolite regions using strictness 'relaxed'

NC_004603.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1.1 | betalactone | 329,511 | 357,829 |
Region 1.2 | arylpolyene | 894,577 | 938,163 | APE Vf | Other | 85%
Region 1.3 | ectoine | 1,828,872 | 1,839,258 | ectoine | Other | 66%
Region 1.4 | RiPP-like | 3,214,141 | 3,225,007 |

NC_004605.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 2.1 | siderophore | 1,772,203 | 1,787,048 | vibrioferrin | Other | 54%

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1.1 | betalactone | 329,511 | 357,829 |
Region 1.2 | arylpolyene | 894,577 | 938,163 | APE Vf | Other | 85%
Region 1.3 | ectoine | 1,828,872 | 1,839,258 | ectoine | Other | 66%
Region 1.4 | RiPP-like | 3,214,141 | 3,225,007 |
Region 2.1 | siderophore | 1,772,203 | 1,787,048 | vibrioferrin | Other | 54%

Compact view
NC_004603.1 - Region 1 - betalactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 329,511 - 357,829 nt. (total: 28,319 nt) Show pHMM detection rules used
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | betalactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001859.1 |  | 0.20 | Other (Phosphonate) | fosfomycin | Pseudomonas syringae
BGC0000904.1 |  | 0.15 | Other | FR-900098 | Streptomyces rubellomurinus
BGC0001441.1 |  | 0.14 | Other | belactosin A, belactosin C | Streptomyces sp.
BGC0000597.1 |  | 0.13 | RiPP | SWA-2138 | Streptomyces sp. e14
BGC0000595.1 |  | 0.13 | RiPP | SCO-2138 | Streptomyces coelicolor A3(2)
BGC0000596.1 |  | 0.13 | RiPP | SLI-2138 | Streptomyces lividans TK24
BGC0000841.1 |  | 0.12 | Other (Non-NRP beta-lactam) | alanylclavam, 2-hydroxymethylclavam, 2-formyloxymethylclavam, clavam-2-carboxylate, clavulanic acid | Streptomyces clavuligerus ATCC 27064
BGC0001164.1 |  | 0.12 | Polyketide | 1-heptadecene | Cyanothece sp. PCC 7822
BGC0001160.1 |  | 0.12 | Polyketide | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0000871.1 |  | 0.12 | Other (Nucleoside) | VEPE, AEPE, TG-1 | Myxococcus xanthus DK 1622

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001859.1 |  | 0.52 | Other (Phosphonate) | fosfomycin | Pseudomonas syringae
BGC0000904.1 |  | 0.45 | Other | FR-900098 | Streptomyces rubellomurinus
BGC0001441.1 |  | 0.44 | Other | belactosin A, belactosin C | Streptomyces sp.
BGC0000597.1 |  | 0.41 | RiPP | SWA-2138 | Streptomyces sp. e14
BGC0000595.1 |  | 0.41 | RiPP | SCO-2138 | Streptomyces coelicolor A3(2)
BGC0000596.1 |  | 0.41 | RiPP | SLI-2138 | Streptomyces lividans TK24
BGC0000841.1 |  | 0.41 | Other (Non-NRP beta-lactam) | alanylclavam, 2-hydroxymethylclavam, 2-formyloxymethylclavam, clavam-2-carboxylate, clavulanic acid | Streptomyces clavuligerus ATCC 27064
BGC0001164.1 |  | 0.40 | Polyketide | 1-heptadecene | Cyanothece sp. PCC 7822
BGC0001160.1 |  | 0.40 | Polyketide | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0000871.1 |  | 0.40 | Other (Nucleoside) | VEPE, AEPE, TG-1 | Myxococcus xanthus DK 1622

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_004603.1 - Region 2 - arylpolyene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 894,577 - 938,163 nt. (total: 43,587 nt) Show pHMM detection rules used
arylpolyene: (APE_KS1 or APE_KS2)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | arylpolyene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000837.1 |  | 0.51 | Other | APE Vf | Aliivibrio fischeri ES114
BGC0000836.1 |  | 0.32 | Other | APE Ec | Escherichia coli CFT073
BGC0002008.1 |  | 0.31 | Other | aryl polyenes | Xenorhabdus doucetiae
BGC0000236.1 |  | 0.23 | Polyketide | kinamycin | Streptomyces murayamaensis
BGC0001596.1 |  | 0.22 | Polyketide | fluostatins M-Q | Streptomyces albus
BGC0000228.1 |  | 0.22 | Polyketide | granaticin | Streptomyces violaceoruber
BGC0001904.1 |  | 0.22 | Polyketide | fluostatin | Micromonospora rosaria
BGC0001890.1 |  | 0.22 | NRP | amphi-enterobactin 1, amphi-enterobactin 2, amphi-enterobactin 3, amphi-enterobactin 4 | Vibrio campbellii ATCC BAA-1116
BGC0000237.1 |  | 0.22 | Polyketide | lactonamycin Z | Streptomyces sanglieri
BGC0000248.1 |  | 0.21 | Polyketide | naphtocyclinone | Streptomyces arenae

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000837.1 |  | 0.79 | Other | APE Vf | Aliivibrio fischeri ES114
BGC0000836.1 |  | 0.65 | Other | APE Ec | Escherichia coli CFT073
BGC0002008.1 |  | 0.64 | Other | aryl polyenes | Xenorhabdus doucetiae
BGC0000236.1 |  | 0.56 | Polyketide | kinamycin | Streptomyces murayamaensis
BGC0001596.1 |  | 0.55 | Polyketide | fluostatins M-Q | Streptomyces albus
BGC0000228.1 |  | 0.55 | Polyketide | granaticin | Streptomyces violaceoruber
BGC0001904.1 |  | 0.55 | Polyketide | fluostatin | Micromonospora rosaria
BGC0001890.1 |  | 0.55 | NRP | amphi-enterobactin 1, amphi-enterobactin 2, amphi-enterobactin 3, amphi-enterobactin 4 | Vibrio campbellii ATCC BAA-1116
BGC0000237.1 |  | 0.55 | Polyketide | lactonamycin Z | Streptomyces sanglieri
BGC0000248.1 |  | 0.54 | Polyketide | naphtocyclinone | Streptomyces arenae

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_004603.1 - Region 3 - ectoine
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,828,872 - 1,839,258 nt. (total: 10,387 nt) Show pHMM detection rules used
ectoine: ectoine_synt

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | ectoine | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000856.1 |  | 0.53 | Other | ectoine | Methylophaga thalassica
BGC0000859.1 |  | 0.53 | Other | ectoine | Methylomicrobium alcaliphilum
BGC0000855.1 |  | 0.43 | Other | ectoine | Methylomicrobium kenyense
BGC0000852.1 |  | 0.39 | Other | ectoine | Sporosarcina pasteurii
BGC0000857.1 |  | 0.38 | Other | ectoine | Methylophaga alcalica
BGC0000860.1 |  | 0.37 | Other | ectoine | Methylarcula marina
BGC0000854.1 |  | 0.33 | Other | ectoine | Methylomicrobium alcaliphilum 20Z
BGC0000858.1 |  | 0.33 | Other | ectoine | Methylobacter marinus
BGC0000853.1 |  | 0.33 | Other | ectoine | Streptomyces anulatus
BGC0000919.1 |  | 0.14 | Other | phaseolotoxin | Pseudomonas syringae

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000856.1 |  | 0.80 | Other | ectoine | Methylophaga thalassica
BGC0000859.1 |  | 0.80 | Other | ectoine | Methylomicrobium alcaliphilum
BGC0000855.1 |  | 0.74 | Other | ectoine | Methylomicrobium kenyense
BGC0000852.1 |  | 0.71 | Other | ectoine | Sporosarcina pasteurii
BGC0000857.1 |  | 0.70 | Other | ectoine | Methylophaga alcalica
BGC0000860.1 |  | 0.69 | Other | ectoine | Methylarcula marina
BGC0000854.1 |  | 0.66 | Other | ectoine | Methylomicrobium alcaliphilum 20Z
BGC0000858.1 |  | 0.66 | Other | ectoine | Methylobacter marinus
BGC0000853.1 |  | 0.66 | Other | ectoine | Streptomyces anulatus
BGC0000919.1 |  | 0.43 | Other | phaseolotoxin | Pseudomonas syringae

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_004603.1 - Region 4 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,214,141 - 3,225,007 nt. (total: 10,867 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000929.1 |  | 0.14 | Other | xanthothricin | Burkholderia glumae
BGC0001133.1 |  | 0.08 | NRP | taxlllaid A | Xenorhabdus bovienii SS-2004
BGC0000955.1 |  | 0.06 | NRP, Polyketide | althiomycin | Myxococcus xanthus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000929.1 |  | 0.43 | Other | xanthothricin | Burkholderia glumae
BGC0001133.1 |  | 0.31 | NRP | taxlllaid A | Xenorhabdus bovienii SS-2004
BGC0000955.1 |  | 0.27 | NRP, Polyketide | althiomycin | Myxococcus xanthus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_004605.1 - Region 1 - siderophore
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,772,203 - 1,787,048 nt. (total: 14,846 nt) Show pHMM detection rules used
siderophore: IucA_IucC

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | siderophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000946.1 |  | 0.82 | Other | vibrioferrin | Vibrio parahaemolyticus
BGC0000947.1 |  | 0.41 | Other | vibrioferrin | Vibrio alginolyticus
BGC0001408.1 |  | 0.39 | Other | xanthoferrin | Xanthomonas oryzae pv. oryzae KACC 10331
BGC0000942.1 |  | 0.25 | Other | petrobactin | Bacillus anthracis str. Ames
BGC0001555.1 |  | 0.20 | RiPP | colicin V | Escherichia coli chi7122
BGC0000550.1 |  | 0.16 | RiPP | salivaricin G32 | Streptococcus salivarius
BGC0000943.1 |  | 0.15 | Other | staphylobactin | Staphylococcus aureus subsp. aureus NCTC 8325
BGC0000883.1 |  | 0.15 | Other | arginomycin | Streptomyces arginensis
BGC0000515.1 |  | 0.14 | RiPP | geobacillin I | Geobacillus thermodenitrificans NG80-2
BGC0000506.1 |  | 0.14 | RiPP | entianin | Bacillus subtilis subsp. spizizenii

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000946.1 |  | 0.94 | Other | vibrioferrin | Vibrio parahaemolyticus
BGC0000947.1 |  | 0.73 | Other | vibrioferrin | Vibrio alginolyticus
BGC0001408.1 |  | 0.71 | Other | xanthoferrin | Xanthomonas oryzae pv. oryzae KACC 10331
BGC0000942.1 |  | 0.59 | Other | petrobactin | Bacillus anthracis str. Ames
BGC0001555.1 |  | 0.52 | RiPP | colicin V | Escherichia coli chi7122
BGC0000550.1 |  | 0.46 | RiPP | salivaricin G32 | Streptococcus salivarius
BGC0000943.1 |  | 0.46 | Other | staphylobactin | Staphylococcus aureus subsp. aureus NCTC 8325
BGC0000883.1 |  | 0.44 | Other | arginomycin | Streptomyces arginensis
BGC0000515.1 |  | 0.44 | RiPP | geobacillin I | Geobacillus thermodenitrificans NG80-2
BGC0000506.1 |  | 0.43 | RiPP | entianin | Bacillus subtilis subsp. spizizenii

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names