LOCUS       NZ_CP125875.1          10873 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP125875.1 Vibrio harveyi strain SB1 chromosome I, complete
            sequence.
ACCESSION   NZ_CP125875
VERSION     NZ_CP125875.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 12:59:15
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 3149893
            Orig. end    :: 3160766
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10873
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[3154893:3155766](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5873)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10873
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10873
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="4"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(1132..2103)
                     /gene_functions="regulatory (smcogs) SMCOG1125:LysR family
                     transcriptional regulator (Score: 255.9; E-value: 8.7e-78)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_2791"
                     /transl_table=11
                     /translation="MTIIPMGKITVNVEKLARIDLNLLVCFKVLIEELNVTRAAHRLCL
                     SQSAVSKSLAKLRTQFDDPLFTRNSHGLTPTPRALFLKPKLDLLINQLEVLTQPEEFSP
                     QSSEYRFQIAAVESVYPLILPHFLPAIFQQAPGVTISTHSWSEQTFKMIQRGEIDLGMT
                     GRDIDINDAKLTMLPPDDICEQEIYRDHQMCIVRKDHPALRSNWNLEAYLALRHVQVRC
                     DGNDRWLLDYRLADIGRERDIAVTVPDFNSAASLCSYTDFVFTAPSHFVKLAAKQHDMA
                     LLPLPLEFPPMAYTLFWHRDRENDPALTWLRTMITQKTDHLR"
     PFAM_domain     complement(1150..1788)
                     /aSDomain="LysR_substrate"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03466.22"
                     /description="LysR substrate binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2791_0118"
                     /evalue="2.70E-30"
                     /label="ctg1_2791"
                     /locus_tag="ctg1_2791"
                     /protein_end="318"
                     /protein_start="105"
                     /score="105.4"
                     /tool="antismash"
                     /translation="SSEYRFQIAAVESVYPLILPHFLPAIFQQAPGVTISTHSWSEQTF
                     KMIQRGEIDLGMTGRDIDINDAKLTMLPPDDICEQEIYRDHQMCIVRKDHPALRSNWNL
                     EAYLALRHVQVRCDGNDRWLLDYRLADIGRERDIAVTVPDFNSAASLCSYTDFVFTAPS
                     HFVKLAAKQHDMALLPLPLEFPPMAYTLFWHRDRENDPALTWLRTMITQK"
     PFAM_domain     complement(1867..2043)
                     /aSDomain="HTH_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00126.29"
                     /description="Bacterial regulatory helix-turn-helix
                     protein, lysR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2791_0117"
                     /evalue="3.10E-16"
                     /label="ctg1_2791"
                     /locus_tag="ctg1_2791"
                     /protein_end="79"
                     /protein_start="20"
                     /score="59.2"
                     /tool="antismash"
                     /translation="LNLLVCFKVLIEELNVTRAAHRLCLSQSAVSKSLAKLRTQFDDPL
                     FTRNSHGLTPTPRA"
     CDS             2181..3374
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 92.5; E-value:
                     3.2e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_2792"
                     /transl_table=11
                     /translation="VSSHITNSKKQMALLTMLVLFSPLAIDIYLPALPLIASTFQVENA
                     LAQDTITWFLFAMGVGQLFAGPLADKLGRRTVALGGITIYALSALLAWSAQNIEWMLAA
                     RLLQGLGACATSVAAFATVRDIFGPEKSGKMISYLNGAICFIPALAPILGSWLTQQFDW
                     RANFSFMAGFAVIAGAMMFFGMKETNPATEKQAVFKLSRYWAVLSTPSFIFHASLCLMA
                     MAVILAYVTSAPVVLMTGMGLSMNEFTFWFGLNAAFNIAACMLAPKFMDRWGTHNSLVV
                     GICLLAIAGVIMMVMKEHHTALSFMLPIFISSVGFAWILGAAAGKALEPFGDKAGTAAA
                     LLGLFQMSGSGLLVGTLQRLSLDPQTLIAIHMWVLLPALVILFSKAGKNWHAKLANA"
     aSDomain        2205..3317
                     /aSDomain="TIGR00710"
                     /aSTool="tigrfam"
                     /description="efflux_Bcr_CflA: drug resistance transporter,
                     Bcr/CflA subfamily"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_2792_0035"
                     /evalue="5.00E-74"
                     /identifier="TIGR00710"
                     /label="ctg1_2792"
                     /locus_tag="ctg1_2792"
                     /protein_end="379"
                     /protein_start="8"
                     /score="248.0"
                     /tool="antismash"
                     /translation="KKQMALLTMLVLFSPLAIDIYLPALPLIASTFQVENALAQDTITW
                     FLFAMGVGQLFAGPLADKLGRRTVALGGITIYALSALLAWSAQNIEWMLAARLLQGLGA
                     CATSVAAFATVRDIFGPEKSGKMISYLNGAICFIPALAPILGSWLTQQFDWRANFSFMA
                     GFAVIAGAMMFFGMKETNPATEKQAVFKLSRYWAVLSTPSFIFHASLCLMAMAVILAYV
                     TSAPVVLMTGMGLSMNEFTFWFGLNAAFNIAACMLAPKFMDRWGTHNSLVVGICLLAIA
                     GVIMMVMKEHHTALSFMLPIFISSVGFAWILGAAAGKALEPFGDKAGTAAALLGLFQMS
                     GSGLLVGTLQRLSLDPQTLIAIHMWVLLPAL"
     PFAM_domain     2229..3236
                     /aSDomain="MFS_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07690.18"
                     /description="Major Facilitator Superfamily"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2792_0119"
                     /evalue="2.70E-46"
                     /label="ctg1_2792"
                     /locus_tag="ctg1_2792"
                     /protein_end="352"
                     /protein_start="16"
                     /score="158.2"
                     /tool="antismash"
                     /translation="MLVLFSPLAIDIYLPALPLIASTFQVENALAQDTITWFLFAMGVG
                     QLFAGPLADKLGRRTVALGGITIYALSALLAWSAQNIEWMLAARLLQGLGACATSVAAF
                     ATVRDIFGPEKSGKMISYLNGAICFIPALAPILGSWLTQQFDWRANFSFMAGFAVIAGA
                     MMFFGMKETNPATEKQAVFKLSRYWAVLSTPSFIFHASLCLMAMAVILAYVTSAPVVLM
                     TGMGLSMNEFTFWFGLNAAFNIAACMLAPKFMDRWGTHNSLVVGICLLAIAGVIMMVMK
                     EHHTALSFMLPIFISSVGFAWILGAAAGKALEPFGDKAGTAAALLGLFQMSGSGL"
     CDS             3466..3747
                     /locus_tag="ctg1_2793"
                     /transl_table=11
                     /translation="MSLTTYEMARILEQMEESPEKVMFGKLLNELGNQSSERIRSAAKQ
                     VPVPVLRDIVYQFQQVIESRKGEQVEQMAKDLAKQGISPEELLAYLNK"
     CDS             complement(3780..4235)
                     /locus_tag="ctg1_2794"
                     /transl_table=11
                     /translation="MTDTVKNLVNRYDDLISTLQAGFVPLLLLFCRLWVAWVFFNSGLI
                     KLSSWDSTLYLFELEYQVPILPWELAAYLGTAAELVLPVFLALGLITRPMAAILFVFNI
                     IAVVSYPLLWEKGFYDHQLWGLMILVVIVWGPGPLSLDHILKKKITH"
     PFAM_domain     complement(3912..4157)
                     /aSDomain="DoxX"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07681.14"
                     /description="DoxX"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2794_0120"
                     /evalue="5.40E-18"
                     /label="ctg1_2794"
                     /locus_tag="ctg1_2794"
                     /protein_end="108"
                     /protein_start="26"
                     /score="65.5"
                     /tool="antismash"
                     /translation="LLLFCRLWVAWVFFNSGLIKLSSWDSTLYLFELEYQVPILPWELA
                     AYLGTAAELVLPVFLALGLITRPMAAILFVFNIIAVV"
     CDS             complement(4246..5004)
                     /locus_tag="ctg1_2795"
                     /transl_table=11
                     /translation="MNLATLQSQFAKALHYQALGEDCDIASDEFTADERMQIYRNNFIV
                     SLSEVLSATYPMVEALLGEECFEQMARQHVLTYPLEEGNVVHYGEGFQDTIMQFSQVIA
                     QAPYSPEVARFEWHIDLACQAQYEQSSAAQLKPLVLLGEVSEEQQPALVLHLKQGCRSF
                     DSSYAVFDLFSAIQTGQFEQLNINQLQQGVISIQANGEALCHALDADVFQLLQCLEQKQ
                     SLSEIPEVLLAHLNSIMALDLVDGFTLKSI"
     PFAM_domain     complement(4723..4989)
                     /aSDomain="DUF2063"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09836.11"
                     /description="Putative DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2795_0121"
                     /evalue="2.10E-22"
                     /label="ctg1_2795"
                     /locus_tag="ctg1_2795"
                     /protein_end="94"
                     /protein_start="5"
                     /score="79.2"
                     /tool="antismash"
                     /translation="LQSQFAKALHYQALGEDCDIASDEFTADERMQIYRNNFIVSLSEV
                     LSATYPMVEALLGEECFEQMARQHVLTYPLEEGNVVHYGEGFQD"
     CDS             complement(5001..5873)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_2796"
                     /sec_met_domain="DUF692 (E-value: 2.1e-88, bitscore: 293.5,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VKHHTFHDLVGVGLRTPHLDYFSQNKPELSWLEIHSENYFQPNAA
                     ERNQLQALREQYQISCHGIGLSLGSVERVNQKHLAQLKALIDSIDPILVSDHLSWSENG
                     GHYFNDLLPLPYTEEALKVFTRNVNEVQDYLQREILIENPSSYVKFQHSTISEWEFLTE
                     VQKRTDCRLLLDLNNVYVSAFNHGFDCDTYLDAIPADKVDEIHLAGFTIKQLDKGEIWI
                     DTHSRPVSDEVWQLFAQWTKKHGPRHALIEWDLDIPAPEVLLGEAQKASRLLLQGTLPS
                     EQSEPRKAS"
     PFAM_domain     complement(5055..5846)
                     /aSDomain="DUF692"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05114.15"
                     /description="Protein of unknown function (DUF692)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2796_0122"
                     /evalue="1.90E-106"
                     /label="ctg1_2796"
                     /locus_tag="ctg1_2796"
                     /protein_end="273"
                     /protein_start="9"
                     /score="355.2"
                     /tool="antismash"
                     /translation="VGVGLRTPHLDYFSQNKPELSWLEIHSENYFQPNAAERNQLQALR
                     EQYQISCHGIGLSLGSVERVNQKHLAQLKALIDSIDPILVSDHLSWSENGGHYFNDLLP
                     LPYTEEALKVFTRNVNEVQDYLQREILIENPSSYVKFQHSTISEWEFLTEVQKRTDCRL
                     LLDLNNVYVSAFNHGFDCDTYLDAIPADKVDEIHLAGFTIKQLDKGEIWIDTHSRPVSD
                     EVWQLFAQWTKKHGPRHALIEWDLDIPAPEVLLGEAQKASRL"
     CDS             complement(5960..6220)
                     /locus_tag="ctg1_2797"
                     /transl_table=11
                     /translation="MKKSNLAVTAAVTGLLALGGTMLTAAPAVAADKEKCYGVSKAGKN
                     DCATKSSSCAGTSKEDNQKDAFVVVPKGLCDKLVGGSTSSS"
     PFAM_domain     complement(5975..6124)
                     /aSDomain="DUF2282"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF10048.11"
                     /description="Predicted integral membrane protein
                     (DUF2282)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2797_0123"
                     /evalue="5.00E-23"
                     /label="ctg1_2797"
                     /locus_tag="ctg1_2797"
                     /protein_end="82"
                     /protein_start="32"
                     /score="81.0"
                     /tool="antismash"
                     /translation="KEKCYGVSKAGKNDCATKSSSCAGTSKEDNQKDAFVVVPKGLCDK
                     LVGGS"
     CDS             6501..8675
                     /locus_tag="ctg1_2798"
                     /transl_table=11
                     /translation="MMDPSLLLDGLNDKQREAVAAPLENLLVLAGAGSGKTRVLVHRIA
                     WLMSVEQSSPFSIMSVTFTNKAAAEMRGRIEELMMGSAGGMWNGTFHGICHRILRAHYL
                     DAKLPEDFQIIDSDDQQRLLKRLIKAQNLDEKQWPARQVAWWINGKKDEGLRPSHIDAY
                     HDPVTKTYLQLYTAYQEACDRAGLVDFAEILLRAHELLRDNKFVREHYQARFKHILVDE
                     FQDTNNIQYAWLRMMAGPECHVMIVGDDDQSIYGWRGAKVENIEKFTLEFPSVNTIRLE
                     QNYRSTKTILEASNALIANNTERMGKELWTDGVVGEPISIYSAYNELDEARFAVNKIKE
                     WQDKGGALNDAAMLYRNNAQSRVLEEALIQAGLPYRIYGGMRFFERQEIKDALSYMRLI
                     ANRNDDAAFERVVNTPTRGLGDKTLETIRFAARDRGCTMWEASVAMLDEKVLAGRAAGA
                     LSRFIELVTALEDDTIEMPLHHQTDHVIKYSGLFAMYEQEKGEKSKARIENLEELVTAT
                     RQFEKPEEAEDMSLLTAFLTHAALEAGEGQADEFEDAVQLMTLHSAKGLEFPLVFMVGV
                     EEGMFPSQMSAEEAGRLEEERRLCYVGMTRAMQKLYITYAEMRRLYGQDKYHKPSRFIR
                     ELPETCLDEVRMKAQVSRPASSGRFSQTAVKESFNETGFTLGSRVMHPKFGEGTIINFE
                     GSGPQSRVQIAFNGEGIKWLVTAYARLEKL"
     aSDomain        6519..8666
                     /aSDomain="TIGR01075"
                     /aSTool="tigrfam"
                     /description="uvrD: DNA helicase II"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_2798_0036"
                     /evalue="0.00E+00"
                     /identifier="TIGR01075"
                     /label="ctg1_2798"
                     /locus_tag="ctg1_2798"
                     /protein_end="722"
                     /protein_start="6"
                     /score="1324.3"
                     /tool="antismash"
                     /translation="LLDGLNDKQREAVAAPLENLLVLAGAGSGKTRVLVHRIAWLMSVE
                     QSSPFSIMSVTFTNKAAAEMRGRIEELMMGSAGGMWNGTFHGICHRILRAHYLDAKLPE
                     DFQIIDSDDQQRLLKRLIKAQNLDEKQWPARQVAWWINGKKDEGLRPSHIDAYHDPVTK
                     TYLQLYTAYQEACDRAGLVDFAEILLRAHELLRDNKFVREHYQARFKHILVDEFQDTNN
                     IQYAWLRMMAGPECHVMIVGDDDQSIYGWRGAKVENIEKFTLEFPSVNTIRLEQNYRST
                     KTILEASNALIANNTERMGKELWTDGVVGEPISIYSAYNELDEARFAVNKIKEWQDKGG
                     ALNDAAMLYRNNAQSRVLEEALIQAGLPYRIYGGMRFFERQEIKDALSYMRLIANRNDD
                     AAFERVVNTPTRGLGDKTLETIRFAARDRGCTMWEASVAMLDEKVLAGRAAGALSRFIE
                     LVTALEDDTIEMPLHHQTDHVIKYSGLFAMYEQEKGEKSKARIENLEELVTATRQFEKP
                     EEAEDMSLLTAFLTHAALEAGEGQADEFEDAVQLMTLHSAKGLEFPLVFMVGVEEGMFP
                     SQMSAEEAGRLEEERRLCYVGMTRAMQKLYITYAEMRRLYGQDKYHKPSRFIRELPETC
                     LDEVRMKAQVSRPASSGRFSQTAVKESFNETGFTLGSRVMHPKFGEGTIINFEGSGPQS
                     RVQIAFNGEGIKWLVTAYARLE"
     PFAM_domain     6531..7316
                     /aSDomain="UvrD-helicase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00580.23"
                     /description="UvrD/REP helicase N-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2798_0124"
                     /evalue="9.40E-74"
                     /label="ctg1_2798"
                     /locus_tag="ctg1_2798"
                     /protein_end="272"
                     /protein_start="10"
                     /score="248.8"
                     /tool="antismash"
                     /translation="LNDKQREAVAAPLENLLVLAGAGSGKTRVLVHRIAWLMSVEQSSP
                     FSIMSVTFTNKAAAEMRGRIEELMMGSAGGMWNGTFHGICHRILRAHYLDAKLPEDFQI
                     IDSDDQQRLLKRLIKAQNLDEKQWPARQVAWWINGKKDEGLRPSHIDAYHDPVTKTYLQ
                     LYTAYQEACDRAGLVDFAEILLRAHELLRDNKFVREHYQARFKHILVDEFQDTNNIQYA
                     WLRMMAGPECHVMIVGDDDQSIYGWRGAKVENIEKFTLEF"
     PFAM_domain     7332..8351
                     /aSDomain="UvrD_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13361.8"
                     /description="UvrD-like helicase C-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2798_0125"
                     /evalue="2.70E-82"
                     /label="ctg1_2798"
                     /locus_tag="ctg1_2798"
                     /protein_end="617"
                     /protein_start="277"
                     /score="277.1"
                     /tool="antismash"
                     /translation="IRLEQNYRSTKTILEASNALIANNTERMGKELWTDGVVGEPISIY
                     SAYNELDEARFAVNKIKEWQDKGGALNDAAMLYRNNAQSRVLEEALIQAGLPYRIYGGM
                     RFFERQEIKDALSYMRLIANRNDDAAFERVVNTPTRGLGDKTLETIRFAARDRGCTMWE
                     ASVAMLDEKVLAGRAAGALSRFIELVTALEDDTIEMPLHHQTDHVIKYSGLFAMYEQEK
                     GEKSKARIENLEELVTATRQFEKPEEAEDMSLLTAFLTHAALEAGEGQADEFEDAVQLM
                     TLHSAKGLEFPLVFMVGVEEGMFPSQMSAEEAGRLEEERRLCYVGMTRAMQKLYITYAE
                     "
ORIGIN
        1 tgcctgcgat ttcaaccgcg tttttcgccg cttttggcat taggcatggg tcagctttac
       61 tcaccactga tgcgccagca ttttgtagaa ccaacttaaa ccatgcgtta cttgtcgcag
      121 ggtcaaccag tacattcttg ccagttagag tttctagtcg tgcttgtaat gcttctgggt
      181 gatgaactgt tacgccagaa ccaacgtgag cgtcaaactc agcaggtagg cgagctggat
      241 ctaggaagta ttccacgctt gaatctgaat gcagaatcgc gtgagaaagc agaactggta
      301 gacgtgatac atcaagacca cgaacgttga gtaaccaaca gatagaatca agtgctgtga
      361 tcactgcgct gtctgcgccg gtttttttca ccagctctgc gatttcttga cgtttgcttt
      421 cacttgattg tccaaccgct tctgttgcca ttaggcgaac atcagaaacc acaggagcag
      481 ggcggtcgtg ccacagctca tcaattgggt tgctggcgag aatcttaagc tcaagtgcgc
      541 ctgcaagttt tgcttgtgcc atgtctagcc aagcagagtt gtgcatgcga gggtcgattg
      601 ccacagacgc gccatttgca agatggtctt taatccaatc tagtgctggt tcttcaatta
      661 ggtgacggta ttcgaataga tcagcaggaa cctgcttagt gacttgtacc gtgtagcgac
      721 catcaacaaa gatagcggct ttgtctttgg tgattaccgc agcaccagca gaaccggtaa
      781 aaccagttag ccagtgtaaa cgctcgttgt gcgctggtac gtattcgccc aagtactcgt
      841 cttcatgtgg gacaagtagg gcatcaatat tatgttgtgc tagccattcg cgaattgcat
      901 tcacgcggct ttgggtatcg ttgtgcatct gtgttattcc ttcaaattac cgctccttca
      961 tgctcaggtg tgggagctgt ttccatctgc ttcatgcagt ttacgattcc attgaggttc
     1021 gcaatcactt caatagagtc ggagtacaac agaccataga tgagccaaaa aggactatcg
     1081 actgttaagc tactcatttt accgtaagag cgcaaatcgc gtccgggatt tttatctaag
     1141 atgatcggtt ttttgcgtga tcatagtacg tagccaagtt aaagctgggt cattttctct
     1201 gtctcggtgc cagaacaaag tgtaagccat tggcgggaat tcgagtggca gcggcagtaa
     1261 cgccatgtcg tgttgtttag ctgccaactt cacaaagtgg cttggcgcgg taaacacaaa
     1321 atcggtgtaa gaacacaaac tggcggcact gttaaagtcc ggtacggtga ctgcgatatc
     1381 acgttcgcga ccaatgtcgg ctaaacgata gtcgagcaac caacggtcgt tgccatcaca
     1441 acgcacctgt acatgacgca gggctaggta agcttctaag ttccagttac tacgcaaagc
     1501 cgggtggtct ttacgcacga tacacatttg gtggtcgcga tagatttcct gttcacaaat
     1561 gtcatcgggc ggcagcatag tcagcttggc atcgttgatg tcgatatctc gacctgtcat
     1621 gcctaaatcg atttcaccgc gttgaatcat cttgaacgtt tgttccgacc aagagtgggt
     1681 gcttatggtc acgcctggtg cttgttggaa aatcgctggc aagaagtggg gcagaatgag
     1741 cgggtagaca ctctctaccg ctgcgatttg aaaacggtac tcactgctct gtggcgagaa
     1801 ctcttcgggt tgagtcagta cctcaagttg gtttatcaac agatccagtt tcggtttaag
     1861 gaacaatgcg cgcggagttg gcgttaatcc gtgtgagttt cgagtgaata gaggatcatc
     1921 aaattgggta cgtaatttcg ctaaggattt gctcacggca gactgactca agcacagtct
     1981 gtgggcagct cgggtgacat tcaactcttc aatcagcact ttaaaacaga ccagcaaatt
     2041 gaggtcgatg cgtgccagtt tctctacgtt cacagtgatt ttccccattg gaataatggt
     2101 catgagtata catcatttcc attcatatca tcagatgatt aagctttgct caaaagttct
     2161 tgttcaattt ggagtgtttt gtgtctagcc atattacaaa tagcaaaaaa cagatggcgc
     2221 tgttgaccat gttagttctg ttcagtccgc ttgcgattga tatctatcta cctgctttgc
     2281 ctcttatcgc gtccactttt caggtagaaa atgcattggc acaagacacc atcacttggt
     2341 tcctatttgc tatgggtgtt ggtcagctat tcgctggtcc cttggcagat aaactcggac
     2401 gtcgaactgt tgcattggga ggcatcacca tctacgcatt gagcgcttta ttggcgtgga
     2461 gtgctcaaaa tattgagtgg atgttggcgg ctcgcttgct acaaggctta ggtgcatgtg
     2521 caacatctgt agcagccttt gcaacagttc gcgatatctt tggtccggaa aaaagcggca
     2581 aaatgatcag ctaccttaac ggcgcgatct gctttatccc ggcactggca ccgattcttg
     2641 gtagttggtt aacccaacaa tttgattggc gtgcaaactt cagctttatg gcgggtttcg
     2701 ctgtaattgc aggagcgatg atgttctttg ggatgaagga aaccaaccct gcaacagaaa
     2761 agcaggcggt atttaaactg agccgctact gggcagtctt gagcacacca tcattcatct
     2821 tccacgcttc actgtgtttg atggcgatgg cggtcattct tgcttatgta acgtctgcac
     2881 ctgtagtgtt gatgacaggc atgggactat cgatgaatga attcaccttc tggtttggtc
     2941 tgaatgcggc gttcaacatt gctgcttgta tgcttgcgcc taagttcatg gatcgctggg
     3001 gcacacacaa ttcactggtt gttggtatct gcttactggc aattgctggc gtgatcatga
     3061 tggtgatgaa agagcaccac acggcactgt ctttcatgct accaatcttt atctcatcgg
     3121 tcggctttgc ttggattctt ggcgcagcag caggtaaagc gttggaaccg ttcggtgata
     3181 aagcgggtac tgcggctgca ctacttggtt tgttccaaat gagtggctct ggtttgttgg
     3241 tgggtacgct acagcgttta tcactggatc cacaaactct gattgcgatt catatgtggg
     3301 tattgcttcc agcattagtg attctgttta gcaaagctgg taagaactgg catgcgaaat
     3361 tggcgaatgc gtaaaactcg gtaatttagt attttccaat gtacttaacg cgtgtatatt
     3421 tgtcgttcaa acttttctcg acaccataac ggaactcata aagtaatgtc gttaaccacg
     3481 tatgaaatgg ctcgtatcct agagcaaatg gaagagtcac cagaaaaggt gatgtttggt
     3541 aagttgctta acgaattagg taaccaaagc tctgagcgca ttcgtagcgc ggcaaaacaa
     3601 gttccagtgc cagtcctacg cgatatcgtg taccaatttc agcaagtgat tgagtcacgt
     3661 aaaggcgagc aagtagagca gatggcaaaa gatctcgcga agcagggtat ctcacctgaa
     3721 gagctactgg cttacttaaa taaataataa aaaaatcccc gcatcatgcg gggatttttt
     3781 tagtgagtga ttttcttctt cagtatgtgg tcgagggata atggtcctgg tccccaaaca
     3841 atcacaacta ggatcatcaa tccccaaagt tggtgatcat agaaaccttt ctcccataac
     3901 agcgggtaag agaccacggc gatgatgttg aatacaaaca gaatcgcagc catcgggcgg
     3961 gtaatcaatc ctagtgccaa gaacaccggt agaaccaatt ctgcagccgt tcctaagtaa
     4021 gccgccaatt cccatggcag tattggcact tggtattcca gctcaaataa atacagtgtg
     4081 ctatcccaag acgagagttt gattagccct gaattgaaga acacccatgc aacccacaag
     4141 cgacaaaaga gaagtagtaa agggacaaag ccagcttgta gggtgctgat taaatcgtcg
     4201 taccgattca ctaagttttt aaccgtatcc gtcatagagt gctccttaga ttgatttcaa
     4261 tgtaaagccg tcaacgagat cgagtgccat gatgctattg agatgagcga gtaaaacttc
     4321 aggtatttcg ctcaaactct gtttctgctc taaacattgc agcagttgga acacatcggc
     4381 atcgagtgcg tgacacaagg cttctccatt ggcttgaatc gagatgacac cttgctgtaa
     4441 ttggttgata ttaagttgtt cgaattgccc agtttgaatc gcgctgaaca aatcaaatac
     4501 tgcataactg gagtcaaagc tgcggcagcc ttgtttgagg tgcaaaacca aagcgggttg
     4561 ttgctcttca ctcacttcgc caagtaacac aagcggtttt aattgtgcag cactggattg
     4621 ttcatactgc gcttgacaag cgaggtcgat atgccactcg aagcgtgcga cttcagggct
     4681 gtaaggggct tgtgcgatca cctgactaaa ctgcatgatg gtgtcttgaa aaccttcgcc
     4741 ataatgcacc acatttcctt cctctaatgg ataagtgaga acatgttggc gagccatctg
     4801 ttcaaagcat tcttcaccaa gtagcgcttc aaccattggg taggtagcgg ataacacttc
     4861 gcttaagctg acgataaagt tattgcggta aatctgcatg cgttcatcag cggtaaactc
     4921 atcactggca atatcgcaat cttcaccgag tgcttgatag tgtagggctt tagcaaactg
     4981 gctttgtaag gtggctagat tcatgatgcc ttccttggtt cgctttgttc acttggaagt
     5041 gtgccttgca acagcagtcg ggatgctttc tgcgcttctc cgagcaagac ttctggcgcg
     5101 gggatatcca aatcccattc aatcaacgca tgacgtggac cgtgtttttt ggtccactgt
     5161 gcgaacaact gccaaacttc atcactaact gggcggctat gggtatcgat ccatatctca
     5221 cctttgtcga gttgtttgat ggtaaaacct gccaagtgaa tctcatccac tttgtcggct
     5281 ggaattgcat ctaggtatgt gtcgcaatca aaaccgtggt tgaacgccga gacataaaca
     5341 ttgtttaaat cgagcaataa acgacagtca gtgcgctttt gcacttcggt aagaaactcc
     5401 cattcgctga tggtcgaatg ttgaaacttc acataactag atgggttctc tatcaagatc
     5461 tcgcgttgca aataatcctg cacttcattc acgttacgag tgaacacttt gagcgcttct
     5521 tccgtatacg gaagtggaag caggtcatta aagtagtgac cgccgttttc actccaactc
     5581 aaatggtcag aaacaagaat cgggtcgatt gagtcaatca gcgctttaag ttgagcaagg
     5641 tgcttttgat tcacacgttc caccgaacct agtgacagac caatgccatg gcagctaatt
     5701 tgatactgct cgcgcaatgc ttgtaattga ttgcgctcag cagcgttggg ttgaaaatag
     5761 ttttcactgt ggatttctaa ccaagataac tcgggtttgt tttggctaaa gtaatcgagg
     5821 tgaggggttc ttaatccaac tccaactagg tcgtggaagg tgtggtgttt cacgtgaaac
     5881 tccttttcaa atcgtgcggg aagagaagga tgcgctggtt gagcgtcaac gcatccttgc
     5941 agtagctagc gataaaagat tatgaagaag aagtgctacc gccaacgagt ttgtcacata
     6001 gaccttttgg tacgactacg aatgcgtctt tttggttatc ttctttagaa gtaccagcac
     6061 atgagctgct tttcgttgca cagtcgtttt tacctgcttt agaaacgccg tagcactttt
     6121 ctttatcagc agcgacagct ggagctgcag ttagcattgt gccaccaaga gctagaagac
     6181 cagtaacagc agcagtaaca gctagattcg actttttcat aataaattcc tctgaatgat
     6241 ttcctttact ttaagttggc aagatgaatc gcctgttttg gcgtttttgt tatcaacttg
     6301 cttaacttaa aagataggaa actggccaaa aaactttcag aaaaattttc gaaacaaatg
     6361 gttttaaaga atggaattta tataacttat tgatgtgtag agtaaaaaaa cgacgaattt
     6421 tttatgaatt tttgtctaat ctgaagaggt tgtttaggtt ataatctatt tttatgtata
     6481 aataaccagt agctctcatc atgatggatc catctctatt actcgacggt ttgaacgaca
     6541 aacaacgtga agccgttgca gcacctttag aaaacttgct cgtccttgct ggtgcaggga
     6601 gtggtaagac acgcgttctt gttcaccgta tcgcttggtt gatgtcggtc gagcaatcat
     6661 ctccgttctc aatcatgtcg gtaaccttta ccaataaggc ggcggcagag atgcgtggac
     6721 gtatcgaaga gctaatgatg ggcagtgcag gcggtatgtg gaatggtact ttccacggca
     6781 tttgtcaccg cattcttcgc gcgcactatc ttgatgccaa gctaccggaa gatttccaaa
     6841 tcatcgacag tgacgaccaa cagcgtctac taaagcgttt gatcaaagcg caaaacctcg
     6901 atgagaagca atggccagcg cgccaagttg catggtggat taacggcaag aaagacgaag
     6961 gtctgcgccc gtcgcacatt gatgcgtacc atgatccagt gaccaagaca tatctgcagc
     7021 tgtacaccgc ttaccaagaa gcgtgtgatc gtgctggttt agtcgatttt gcggaaatct
     7081 tgctgcgcgc acatgagcta ctgcgtgata acaagttcgt ccgtgaacac taccaagcac
     7141 gctttaagca tatcttggtg gacgagttcc aagataccaa caacattcaa tatgcttggc
     7201 tacgtatgat ggcgggtcct gagtgtcacg tgatgatcgt aggtgatgac gatcagtcga
     7261 tttacggctg gcgtggtgca aaagtcgaga acattgagaa gtttacgctg gaattcccaa
     7321 gcgtgaatac cattcgtctt gagcaaaact accgttcaac caagaccatt ctggaagcgt
     7381 ccaacgctct gatcgcgaat aataccgagc gtatgggtaa agagctttgg acagatggcg
     7441 ttgtcggtga gcctatctcg atttacagcg cttacaacga actagatgaa gcccgttttg
     7501 cggtaaacaa aatcaaagag tggcaagaca agggtggtgc tctgaatgac gctgcaatgc
     7561 tttaccgtaa caacgcccag tcgcgtgttc tggaagaagc attaatccaa gctggtctgc
     7621 cttaccgtat ctacggcggt atgcgattct tcgaacgtca ggaaatcaaa gatgccttga
     7681 gctacatgcg tttgattgcc aaccgtaatg atgatgcggc gtttgaacgt gtagtgaata
     7741 cgccaacacg tggtttgggt gataagacgc ttgaaaccat ccgttttgcg gctcgtgacc
     7801 gtggttgcac catgtgggaa gcgagtgtgg cgatgttgga tgagaaggtg cttgctggtc
     7861 gtgctgctgg tgctctgagc cgttttatcg agcttgtcac agcactagaa gacgacacca
     7921 tcgagatgcc gctgcatcac caaactgacc atgtgatcaa atactcgggc ttgttcgcga
     7981 tgtacgagca ggagaagggt gaaaagtcta aggcgcgtat tgagaacttg gaggaattgg
     8041 tgaccgcaac tcgccaattc gagaaaccag aagaagccga agacatgtca ctgctgacgg
     8101 cattcctaac tcacgcagca ttagaagcgg gcgaaggaca agcagatgag tttgaagacg
     8161 cggttcagct catgacattg cacagtgcga aaggtctaga gttcccattg gtatttatgg
     8221 tcggtgtgga agaaggcatg ttcccaagcc aaatgtcggc agaagaagca gggcgtttgg
     8281 aagaagaacg tcgtctgtgt tatgtaggca tgacccgtgc gatgcagaaa ctgtacatca
     8341 cttatgctga aatgcgtcgt ttgtacggtc aggataagta ccataaaccg tctcgcttta
     8401 tccgtgaact gccagaaact tgtttagacg aagtacgcat gaaggcgcaa gttagccgtc
     8461 ctgcaagcag tggtcgattt agccaaacgg cggtgaaaga gagcttcaat gaaactggct
     8521 ttacgctagg ttctcgtgtg atgcatccta agtttggtga aggcaccatc atcaacttcg
     8581 aaggcagtgg tccacaaagc cgcgtacaga ttgcctttaa cggtgagggc atcaaatggt
     8641 tggtgactgc ttacgctcga ctagagaaac tgtaaggctt ccccaaaact aatcaactta
     8701 agagctgctt cggcggctct ttttgtttgt gctgtttttg tgtcgctaat gcagtaaaaa
     8761 atggaatgat aaatggagtg cgaaagcgcg atttaacgat gctgtttgaa gggaaagttt
     8821 ggtgttgttg gtgaatgtct gttttcagca gagctgttga gaaaaatttt aggcaaagaa
     8881 aaaccccgag ggcttgcgcc catcggggtt atagtcttac tcgcagcaat ccggctacta
     8941 agagtgctcc atgcatctaa tccatgatag tgtgctgaat ccgtcagctt aatccttacg
     9001 tcgccttcct agcggtgtcc ttaatgacct tatcctggtc tgctaaccat cctcgttagc
     9061 tctcatcact tgttccctga gcggtgtccc tgacatcatc ctgatgttca aatccttgcc
     9121 tcgtccagag gtgtccattt cccgtcctta gtagcaacca tcctagtcac tattgattcc
     9181 gttcaatgtc caattttgca atccatgccc gactattcat cctgaataac cgtttcttct
     9241 tcctgaagtt caccaagtcc gtggtgtttc ctgttccgtg tcagcatcct tccgacaggt
     9301 ttaatattac gtgtttaacg atttccaaca acgggctaat ctcacatttt ttcactctct
     9361 tagcgttcaa aaaagataca taaacattaa attcaatgac ttatgctatt tgttgtacgg
     9421 ttttaccatt aaaaaagaga ggtttgctca accctttgtg agagatctcg cacaaggggt
     9481 cgagcgaaag actcttactg cccgatagcg gcgccttcac gccttggatc ggctgcgccc
     9541 tcaagaccgt cttttgttat acgtatcgca tgcagtccag agttcaaatc acgaacatca
     9601 gttttaaaac ccatcttttc caactcaggc tgtaagcctt ctgcagcggt accttgctca
     9661 atatctaagg taccaaaacg gttcagtaat cgtggctgat taatcgcgct ttggatgtcc
     9721 atatcccact gcgtgtgggc gataatggct tgtgcgacgt aaccaatgat gcggctgcca
     9781 cccggtgagc caattgccat gtaaggtttg tcatccttca tcataatggt tggtgccatg
     9841 gatgaacgtg ggcgtttgcc cggttctaag cggttcgcga ttggcacacc atcttgatga
     9901 gtgcggaagg agaagtcggt cagttcgtta ttaagcaaga agcctcgtac catcaagcgt
     9961 gagccaaagg cgttttcaat ggttgttgtc attgaaacca cattgccttg cttatcgacg
    10021 atattgaaat ggctggtgga aggcagctcg atcgattgat ccatgcttaa gttcatcgcg
    10081 tgcgaccaag gagggttgcc ggcttcaacc ttactcaagg ctttaccgac ttgaataagc
    10141 tcagcacgtt gtttgagata atctttatca agcaagcctt cggttggcat tggcacataa
    10201 tcttggtcag ccatgtactt accgcgatcc gcaaacgcaa ggcgagatgc gtcggcgatc
    10261 acttgccacg atttcgcgct ttcggctccc caacctttaa gatcgtattg ctcggtgatc
    10321 gcgagaatct gtccaaccgt caatgcgcca gagcttggtg gtcccatacc gcagatgtca
    10381 tagctttggt aagccgcaca aaccggttca cgttgtttga tttggaacgc atcaaagtca
    10441 ggttgtgcca atacgccagg attgcccggt gcattctgta ctatcttgat gatgtctgtg
    10501 gcgatatcgc cttgatagaa agcttttgcc ccttgctctg caattgccgt cagagtttgc
    10561 gcgtattcag ggtttttcaa caacgtgcct tcggcttttg gtgagccatc tggattaaag
    10621 aagtaagcct tagtcgcagg gaagcgtgat aggcgcttgg catctttctc aatcaggctc
    10681 gcgaggcgag gactgacttc gaaaccttgt tcagccaagg taatcacagg ttggatgatc
    10741 tttttccatt ccaacttgcc gtatttctgg tgcgtgtccc aaagtagttt cactgtgcca
    10801 ggagtggcaa cggatcgccc accgacaacc gcatcgtaaa attgcagtgg ttgtcctttg
    10861 tcatctagga aga
//
