LOCUS       NZ_CP043556.1          10417 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP043556.1 Vibrio cholerae strain RFB16 chromosome 2, complete
            sequence.
ACCESSION   NZ_CP043556
VERSION     NZ_CP043556.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 15:16:33
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 261311
            Orig. end    :: 271728
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10417
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[266311:266728](-)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5417)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
     cand_cluster    1..10417
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10417
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ectoine"
                     /region_number="1"
                     /rules="ectoine_synt"
                     /tool="antismash"
     CDS             1349..1639
                     /locus_tag="ctg2_237"
                     /transl_table=11
                     /translation="MNIRPLHDKLIVERLEVENKSEGGIVLTSQSVKKSNRGKVVAVGL
                     GRPLKNGDRARMEVKTGDQIIFNDGYGVKTEKVDGKEYLILSESDVLAIVE"
     PFAM_domain     1352..1633
                     /aSDomain="Cpn10"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00166.23"
                     /description="Chaperonin 10 Kd subunit"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_237_0001"
                     /evalue="2.10E-29"
                     /label="ctg2_237"
                     /locus_tag="ctg2_237"
                     /protein_end="95"
                     /protein_start="1"
                     /score="101.5"
                     /tool="antismash"
                     /translation="NIRPLHDKLIVERLEVENKSEGGIVLTSQSVKKSNRGKVVAVGLG
                     RPLKNGDRARMEVKTGDQIIFNDGYGVKTEKVDGKEYLILSESDVLAIV"
     CDS             1668..3260
                     /gene_functions="other (smcogs) SMCOG1299:chaperonin GroEL
                     (Score: 818.8; E-value: 2.7e-248)"
                     /gene_kind="other"
                     /locus_tag="ctg2_238"
                     /transl_table=11
                     /translation="MAAKHVLFSTDARQKMLSGVNLLANAVKVTLGPKGRHVVLNKSYG
                     APTITKDGVSVAKEIELADKFENMGAQMLKQVASKANDEAGDGTTTATVLAQALINEGM
                     KAVAAGMNPMDLKRGIDKAVSAAVEKLHQLAKPCSDTQSITQVGAISANSDHAIGEIIA
                     QAMEKVGRNGVITVEEGQALQNELSVVEGMQFDRGYLSPYFINQPKAGCVELENPYVLL
                     VDKKISHIRELLPILESVAKASRSLLIIAEDVDGDALATLVVNSMRGIIKVAAVKAPGF
                     GEQRKAMLEDIAALTAGRVISEEIGLELEKVTLDDLGSAKKVTINKDNTTIVDGAAEPS
                     ALQDRIAQIQHQLEHTTSQYDRDKLQQRIAKLSGGVAVIKIGAATEVEMKEKKDRVDDA
                     LHATRAAVEEGIVAGGGVALLKIANELSNLQGDNDDQNVGIRIALRAMEEPLRQIAINA
                     GDEASVIANQVKTGDEHYGYNAATGQFGNMLEMGILDPAKVTRSALQFAASIAGLMITT
                     EAMVSEVDKESAA"
     aSDomain        1674..3245
                     /aSDomain="TIGR02348"
                     /aSTool="tigrfam"
                     /description="GroEL: chaperonin GroL"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg2_238_0001"
                     /evalue="4.20E-249"
                     /identifier="TIGR02348"
                     /label="ctg2_238"
                     /locus_tag="ctg2_238"
                     /protein_end="526"
                     /protein_start="2"
                     /score="825.3"
                     /tool="antismash"
                     /translation="AKHVLFSTDARQKMLSGVNLLANAVKVTLGPKGRHVVLNKSYGAP
                     TITKDGVSVAKEIELADKFENMGAQMLKQVASKANDEAGDGTTTATVLAQALINEGMKA
                     VAAGMNPMDLKRGIDKAVSAAVEKLHQLAKPCSDTQSITQVGAISANSDHAIGEIIAQA
                     MEKVGRNGVITVEEGQALQNELSVVEGMQFDRGYLSPYFINQPKAGCVELENPYVLLVD
                     KKISHIRELLPILESVAKASRSLLIIAEDVDGDALATLVVNSMRGIIKVAAVKAPGFGE
                     QRKAMLEDIAALTAGRVISEEIGLELEKVTLDDLGSAKKVTINKDNTTIVDGAAEPSAL
                     QDRIAQIQHQLEHTTSQYDRDKLQQRIAKLSGGVAVIKIGAATEVEMKEKKDRVDDALH
                     ATRAAVEEGIVAGGGVALLKIANELSNLQGDNDDQNVGIRIALRAMEEPLRQIAINAGD
                     EASVIANQVKTGDEHYGYNAATGQFGNMLEMGILDPAKVTRSALQFAASIAGLMITTEA
                     MVSEVDK"
     PFAM_domain     1734..3236
                     /aSDomain="Cpn60_TCP1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00118.26"
                     /description="TCP-1/cpn60 chaperonin family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_238_0002"
                     /evalue="4.00E-99"
                     /label="ctg2_238"
                     /locus_tag="ctg2_238"
                     /protein_end="523"
                     /protein_start="22"
                     /score="332.6"
                     /tool="antismash"
                     /translation="LANAVKVTLGPKGRHVVLNKSYGAPTITKDGVSVAKEIELADKFE
                     NMGAQMLKQVASKANDEAGDGTTTATVLAQALINEGMKAVAAGMNPMDLKRGIDKAVSA
                     AVEKLHQLAKPCSDTQSITQVGAISANSDHAIGEIIAQAMEKVGRNGVITVEEGQALQN
                     ELSVVEGMQFDRGYLSPYFINQPKAGCVELENPYVLLVDKKISHIRELLPILESVAKAS
                     RSLLIIAEDVDGDALATLVVNSMRGIIKVAAVKAPGFGEQRKAMLEDIAALTAGRVISE
                     EIGLELEKVTLDDLGSAKKVTINKDNTTIVDGAAEPSALQDRIAQIQHQLEHTTSQYDR
                     DKLQQRIAKLSGGVAVIKIGAATEVEMKEKKDRVDDALHATRAAVEEGIVAGGGVALLK
                     IANELSNLQGDNDDQNVGIRIALRAMEEPLRQIAINAGDEASVIANQVKTGDEHYGYNA
                     ATGQFGNMLEMGILDPAKVTRSALQFAASIAGLMITTEAMVSE"
     CDS             3293..3499
                     /locus_tag="ctg2_239"
                     /transl_table=11
                     /translation="MTKLPHLQLSVVEAQPKTHPANAWPMSMSFPQRCQDRVLMPPYRS
                     VFPTVVLVVYINQAQQQPSPTLH"
     CDS             complement(3580..5001)
                     /locus_tag="ctg2_240"
                     /transl_table=11
                     /translation="MSYTVEKIGGTSMTAFDAVLENILLRPEQPYGRVFVVSAYSGMTD
                     ALLECKRTGAPGIYQKIAKHDESWRDAVYALEQRMLLINENMFADAMTRLRADKFIRAR
                     LAEAIACIQNILQTCQYGQFSLRQYLPQIREFLASLGESHSAYNTALKLNTLGVNARFV
                     DLSGWCEATQGNLDQVIEEAFRDIDVTSELPIVTGYASCQEGLMRTYDRGYSEMTFSRI
                     AVVTGAQQAIIHKEYHLSSADPRLVGAEKVRPIGLTNFDVADQLANLGMEAIHPNAAAG
                     LRQSNIDLRIKNTFEPDHSGTLITASHQPQQDRVEIIAGRDKVFALHLFDQSMVGMMDK
                     VSHELIEWIHAAKVQLIGKEMNANSVTYYLSGSSEPLNHIRYQAEKRYPQAKVSGRMVA
                     LISAIGAHMETNKVLAQGLQALLEHQLQPMAAHSSMRNVNVQFVVDDADYANGVCVLHQ
                     ALMPFAQPSSARKVA"
     PFAM_domain     complement(4123..4992)
                     /aSDomain="AA_kinase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00696.30"
                     /description="Amino acid kinase family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_240_0003"
                     /evalue="1.20E-23"
                     /label="ctg2_240"
                     /locus_tag="ctg2_240"
                     /protein_end="293"
                     /protein_start="3"
                     /score="84.1"
                     /tool="antismash"
                     /translation="TVEKIGGTSMTAFDAVLENILLRPEQPYGRVFVVSAYSGMTDALL
                     ECKRTGAPGIYQKIAKHDESWRDAVYALEQRMLLINENMFADAMTRLRADKFIRARLAE
                     AIACIQNILQTCQYGQFSLRQYLPQIREFLASLGESHSAYNTALKLNTLGVNARFVDLS
                     GWCEATQGNLDQVIEEAFRDIDVTSELPIVTGYASCQEGLMRTYDRGYSEMTFSRIAVV
                     TGAQQAIIHKEYHLSSADPRLVGAEKVRPIGLTNFDVADQLANLGMEAIHPNAAAGLRQ
                     SNIDLRIKN"
     CDS             complement(5001..5417)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg2_241"
                     /sec_met_domain="ectoine_synt (E-value: 8.2e-48, bitscore:
                     157.5, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVRTLEQCRQSERRVVAENWESVRMLLKDDHMGFSFHITTIYAN
                     TQTHIHYRNHLESVYCMSGEGEIEVVGGKTYPIQPGTLYILDQHDEHYLRAFSNEMVMA
                     CVFNPPLTGHEIHDAEGVYPLDKSELMSQCHKEK"
     PFAM_domain     complement(5040..5417)
                     /aSDomain="Ectoine_synth"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF06339.14"
                     /description="Ectoine synthase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_241_0004"
                     /evalue="1.20E-59"
                     /label="ctg2_241"
                     /locus_tag="ctg2_241"
                     /protein_end="126"
                     /protein_start="0"
                     /score="200.2"
                     /tool="antismash"
                     /translation="MIVRTLEQCRQSERRVVAENWESVRMLLKDDHMGFSFHITTIYAN
                     TQTHIHYRNHLESVYCMSGEGEIEVVGGKTYPIQPGTLYILDQHDEHYLRAFSNEMVMA
                     CVFNPPLTGHEIHDAEGVYPLD"
     CDS             complement(5453..6718)
                     /NRPS_PKS="Domain: Aminotran_3 (23-355). E-value: 3.1e-76.
                     Score: 248.4. Matches aSDomain:
                     nrpspksdomains_ctg2_242_Aminotran_3.1"
                     /NRPS_PKS="type: other"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013:aminotransferase class-III (Score: 375.3;
                     E-value: 6.1e-114)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg2_242"
                     /sec_met_domain="Aminotran_3 (E-value: 5.7e-76, bitscore:
                     251.7, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDIFKHHESQVQSYANHFPVLFGTAKGSWLYSQQGDAYLDFLSGA
                     GALNYGHNNAVLKQALLEYIERDGLTHGLDMHSEAKAQFIQALQTHILEPRGLNYKLQF
                     TGPTGTNAVEAALKLARKVTGRHNVVTFTNGFHGCSLGALAATGNQHHRQGAGLALSGV
                     YRVPYDGYAGVDGLTLFETMLQDNSSGLDKPAAVLLETVQGEGGLNVASDAWLQRLQAI
                     CRAQQILLIVDDIQAGCGRTGTFFSFEPSGIEPDMVTLSKSLSGYGLPMALVLFKPEWD
                     QWKPGEHNGTFRGNNHAFVTATRALEAYWANEDFQTHIAARSEQVTQALLQCLSRYPTL
                     FSGLKGRGLMQGLACHNGDIAREIAAICFQKGLIIETAGAEDEVLKVFCPLTITEADLA
                     HGLTIIERCAARIAPRGLQQAS"
     PFAM_domain     complement(5495..6673)
                     /aSDomain="Aminotran_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00202.23"
                     /description="Aminotransferase class-III"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_242_0005"
                     /evalue="1.10E-74"
                     /label="ctg2_242"
                     /locus_tag="ctg2_242"
                     /protein_end="408"
                     /protein_start="15"
                     /score="251.7"
                     /tool="antismash"
                     /translation="NHFPVLFGTAKGSWLYSQQGDAYLDFLSGAGALNYGHNNAVLKQA
                     LLEYIERDGLTHGLDMHSEAKAQFIQALQTHILEPRGLNYKLQFTGPTGTNAVEAALKL
                     ARKVTGRHNVVTFTNGFHGCSLGALAATGNQHHRQGAGLALSGVYRVPYDGYAGVDGLT
                     LFETMLQDNSSGLDKPAAVLLETVQGEGGLNVASDAWLQRLQAICRAQQILLIVDDIQA
                     GCGRTGTFFSFEPSGIEPDMVTLSKSLSGYGLPMALVLFKPEWDQWKPGEHNGTFRGNN
                     HAFVTATRALEAYWANEDFQTHIAARSEQVTQALLQCLSRYPTLFSGLKGRGLMQGLAC
                     HNGDIAREIAAICFQKGLIIETAGAEDEVLKVFCPLTITEADLAHGLTIIERC"
     aSDomain        complement(5495..6715)
                     /aSDomain="TIGR02407"
                     /aSTool="tigrfam"
                     /description="ectoine_ectB: diaminobutyrate--2-oxoglutarate
                     aminotransferase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg2_242_0002"
                     /evalue="1.60E-196"
                     /identifier="TIGR02407"
                     /label="ctg2_242"
                     /locus_tag="ctg2_242"
                     /protein_end="408"
                     /protein_start="1"
                     /score="650.7"
                     /tool="antismash"
                     /translation="DIFKHHESQVQSYANHFPVLFGTAKGSWLYSQQGDAYLDFLSGAG
                     ALNYGHNNAVLKQALLEYIERDGLTHGLDMHSEAKAQFIQALQTHILEPRGLNYKLQFT
                     GPTGTNAVEAALKLARKVTGRHNVVTFTNGFHGCSLGALAATGNQHHRQGAGLALSGVY
                     RVPYDGYAGVDGLTLFETMLQDNSSGLDKPAAVLLETVQGEGGLNVASDAWLQRLQAIC
                     RAQQILLIVDDIQAGCGRTGTFFSFEPSGIEPDMVTLSKSLSGYGLPMALVLFKPEWDQ
                     WKPGEHNGTFRGNNHAFVTATRALEAYWANEDFQTHIAARSEQVTQALLQCLSRYPTLF
                     SGLKGRGLMQGLACHNGDIAREIAAICFQKGLIIETAGAEDEVLKVFCPLTITEADLAH
                     GLTIIERC"
     aSDomain        complement(5495..6715)
                     /aSDomain="TIGR00709"
                     /aSTool="tigrfam"
                     /description="dat: 2,4-diaminobutyrate 4-transaminase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg2_242_0003"
                     /evalue="3.70E-141"
                     /identifier="TIGR00709"
                     /label="ctg2_242"
                     /locus_tag="ctg2_242"
                     /protein_end="408"
                     /protein_start="1"
                     /score="468.6"
                     /tool="antismash"
                     /translation="DIFKHHESQVQSYANHFPVLFGTAKGSWLYSQQGDAYLDFLSGAG
                     ALNYGHNNAVLKQALLEYIERDGLTHGLDMHSEAKAQFIQALQTHILEPRGLNYKLQFT
                     GPTGTNAVEAALKLARKVTGRHNVVTFTNGFHGCSLGALAATGNQHHRQGAGLALSGVY
                     RVPYDGYAGVDGLTLFETMLQDNSSGLDKPAAVLLETVQGEGGLNVASDAWLQRLQAIC
                     RAQQILLIVDDIQAGCGRTGTFFSFEPSGIEPDMVTLSKSLSGYGLPMALVLFKPEWDQ
                     WKPGEHNGTFRGNNHAFVTATRALEAYWANEDFQTHIAARSEQVTQALLQCLSRYPTLF
                     SGLKGRGLMQGLACHNGDIAREIAAICFQKGLIIETAGAEDEVLKVFCPLTITEADLAH
                     GLTIIERC"
     aSDomain        complement(5654..6649)
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg2_242_Aminotran_3.1"
                     /evalue="3.10E-76"
                     /label="ctg2_242_Aminotran_3.1"
                     /locus_tag="ctg2_242"
                     /protein_end="355"
                     /protein_start="23"
                     /score="248.4"
                     /tool="antismash"
                     /translation="TAKGSWLYSQQGDAYLDFLSGAGALNYGHNNAVLKQALLEYIERD
                     GLTHGLDMHSEAKAQFIQALQTHILEPRGLNYKLQFTGPTGTNAVEAALKLARKVTGRH
                     NVVTFTNGFHGCSLGALAATGNQHHRQGAGLALSGVYRVPYDGYAGVDGLTLFETMLQD
                     NSSGLDKPAAVLLETVQGEGGLNVASDAWLQRLQAICRAQQILLIVDDIQAGCGRTGTF
                     FSFEPSGIEPDMVTLSKSLSGYGLPMALVLFKPEWDQWKPGEHNGTFRGNNHAFVTATR
                     ALEAYWANEDFQTHIAARSEQVTQALLQCLSRYPTLFSGLKGRGLMQGLAC"
     CDS             complement(6742..7284)
                     /locus_tag="ctg2_243"
                     /transl_table=11
                     /translation="MFTATPWMIYPQIMHKPALPWVFRRPTQEDGLSIHELIAQCAPLD
                     QNSAYCNFLQSSHFQTTCLMAEQQELLVGFVSAYRKPEQQNELFIWQVAVHPSARGKGL
                     AYQMLKHLLAREDLADITVLETTITRSNQASWRLFQKLDREQGEQGSVSTFLDETCHFE
                     GEHDTEYLYRIPLQSSN"
     aSDomain        complement(6757..7218)
                     /aSDomain="TIGR02406"
                     /aSTool="tigrfam"
                     /description="ectoine_EctA: diaminobutyrate
                     acetyltransferase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg2_243_0004"
                     /evalue="8.70E-58"
                     /identifier="TIGR02406"
                     /label="ctg2_243"
                     /locus_tag="ctg2_243"
                     /protein_end="176"
                     /protein_start="22"
                     /score="192.7"
                     /tool="antismash"
                     /translation="FRRPTQEDGLSIHELIAQCAPLDQNSAYCNFLQSSHFQTTCLMAE
                     QQELLVGFVSAYRKPEQQNELFIWQVAVHPSARGKGLAYQMLKHLLAREDLADITVLET
                     TITRSNQASWRLFQKLDREQGEQGSVSTFLDETCHFEGEHDTEYLYRIPL"
     PFAM_domain     complement(6859..7119)
                     /aSDomain="Acetyltransf_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00583.27"
                     /description="Acetyltransferase (GNAT) family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_243_0006"
                     /evalue="1.80E-12"
                     /label="ctg2_243"
                     /locus_tag="ctg2_243"
                     /protein_end="142"
                     /protein_start="55"
                     /score="47.6"
                     /tool="antismash"
                     /translation="SSHFQTTCLMAEQQELLVGFVSAYRKPEQQNELFIWQVAVHPSAR
                     GKGLAYQMLKHLLAREDLADITVLETTITRSNQASWRLFQKL"
     CDS             complement(7965..8294)
                     /locus_tag="ctg2_244"
                     /transl_table=11
                     /translation="MLDELRCEACSADAIGLTSEEQQQLLSELDGWALIHRDGIAQLEK
                     RYRFKNFKQAWAFSNQIAELAEQEFHHPAILLEWGNVTVTWWSHSIKGLHKNDFICAAK
                     CDALT"
     PFAM_domain     complement(7974..8246)
                     /aSDomain="Pterin_4a"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01329.21"
                     /description="Pterin 4 alpha carbinolamine dehydratase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_244_0007"
                     /evalue="8.40E-32"
                     /label="ctg2_244"
                     /locus_tag="ctg2_244"
                     /protein_end="107"
                     /protein_start="16"
                     /score="109.3"
                     /tool="antismash"
                     /translation="LTSEEQQQLLSELDGWALIHRDGIAQLEKRYRFKNFKQAWAFSNQ
                     IAELAEQEFHHPAILLEWGNVTVTWWSHSIKGLHKNDFICAAKCDA"
     CDS             complement(8284..9078)
                     /locus_tag="ctg2_245"
                     /transl_table=11
                     /translation="MTQYHSKPVSEHGHIDWDQDEHAVWHELITRQQEVVKTRACQAYL
                     DGLNMLNLPTDRLPQLPEINRVLQTETGWQVEPVPALISFDRFFALLADKKFPVATFLR
                     RRDEFDYLQEPDFFHEVYGHCAMLTHPDFAAFTHVYGQLGAKATPKERSYLARLYWFTV
                     EFGLVQEQGQTKIYGGGILSSPGETLYASESTIPKREPFDIMQVLRTPYRIDIMQPIYY
                     VLPDLSQLYQLSQRDVMGLVWQAMQDGLLPPLFQPKEQQHAG"
     aSDomain        complement(8323..9042)
                     /aSDomain="TIGR01267"
                     /aSTool="tigrfam"
                     /description="Phe4hydrox_mono: phenylalanine-4-hydroxylase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg2_245_0005"
                     /evalue="1.60E-98"
                     /identifier="TIGR01267"
                     /label="ctg2_245"
                     /locus_tag="ctg2_245"
                     /protein_end="252"
                     /protein_start="12"
                     /score="326.9"
                     /tool="antismash"
                     /translation="GHIDWDQDEHAVWHELITRQQEVVKTRACQAYLDGLNMLNLPTDR
                     LPQLPEINRVLQTETGWQVEPVPALISFDRFFALLADKKFPVATFLRRRDEFDYLQEPD
                     FFHEVYGHCAMLTHPDFAAFTHVYGQLGAKATPKERSYLARLYWFTVEFGLVQEQGQTK
                     IYGGGILSSPGETLYASESTIPKREPFDIMQVLRTPYRIDIMQPIYYVLPDLSQLYQLS
                     QRDVMGLVWQAMQDGLLP"
     PFAM_domain     complement(8392..9042)
                     /aSDomain="Biopterin_H"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00351.23"
                     /description="Biopterin-dependent aromatic amino acid
                     hydroxylase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_245_0008"
                     /evalue="1.00E-47"
                     /label="ctg2_245"
                     /locus_tag="ctg2_245"
                     /protein_end="229"
                     /protein_start="12"
                     /score="162.9"
                     /tool="antismash"
                     /translation="GHIDWDQDEHAVWHELITRQQEVVKTRACQAYLDGLNMLNLPTDR
                     LPQLPEINRVLQTETGWQVEPVPALISFDRFFALLADKKFPVATFLRRRDEFDYLQEPD
                     FFHEVYGHCAMLTHPDFAAFTHVYGQLGAKATPKERSYLARLYWFTVEFGLVQEQGQTK
                     IYGGGILSSPGETLYASESTIPKREPFDIMQVLRTPYRIDIMQPIYYVLPDLSQ"
ORIGIN
        1 aaccgagatg cgcgccgagg tgcggatttc ggtcattaac gcgttgtcgg aaattgaact
       61 caaactgacg ctggctaagc tcgataacct gtcactgatc gagtgggaag actcgctacc
      121 cgatgacatc atcagtgaag cattaagcct tattaaccgt gatgaacttg agctatacga
      181 ccaagccaac gagtttgcag atgatgaaat tggccactgg gcggatcgaa aagtttatac
      241 cttacctttt agcatcagtg ttcgccgcgc caaagtcttg ttggataaat atcactacga
      301 ctcccctcaa tacatttacc tcatcaacaa agccaaaaag ttccgtggct tagtaagctt
      361 tagtgatgta ttgcaagccg aagaaaccac tcagctcaag aacttgcgta tggaagaact
      421 ggtgacgctc aatgcgcagc aaaccttatc agacgcggtg gatgccctcg aacacaccac
      481 attaccaatt gtgccagtac tgagtgacga tgaaaccttg attggtgaaa ttgactggca
      541 ttttgcgctc agcgtgcaac gtgaaatgta tgaagcacgc ctgatggccg gtaccggtat
      601 ggatgaaggt gatgatctgt tcgcgccagt catcaaaagc tcgaaaaaac gcgggttgtg
      661 gctcggcatt aaccttctga ccgccattct tgcctccatc accattggct tatttgagaa
      721 tgtcatttcg caagttgtcg ctttagcggt gctgatgcca attgtcgctt cgatgggtgg
      781 cattgcggga agccaaacct tgactttgat ggtacgcgcg atggcgctta atcagatcac
      841 cgtgggtaac cgttttgctt tgctgaaaaa tgagctggga attggttcga tcaatggtct
      901 cgtctgggcg ctgatcatcg gtggtatggc ggcactttgg ttccaagagc cggtgatcgg
      961 cgcaaccctt gcgctggcaa ttgtggtcaa cattattacc gcagcattat ttggggtgtt
     1021 gatcccgata attttggaca aattcaagct cgatcccgcg ctggcaggtt cggttattct
     1081 caccaccgtg accgatgtgg tcggcttttt tgccttcctc ggcaccgcca gtttggtgat
     1141 gttgtagccg ccatcaaacc ctagaaaaaa tttttatttc ccctcttgaa cttcgatttt
     1201 cttaccctat ttatatcggc gagtggcagt gatgccccgc cgagactgga ttgattgctt
     1261 ctagcttcgc gtgaaactga gctcattttg caaacaatcc taccggcctt ttatcttgat
     1321 agtgacattt aagtaggagg cattcccaat gaatattcgt cctttacatg acaagttgat
     1381 tgttgaaaga ctggaagtcg aaaacaagtc tgagggcgga atcgtactca cttctcaatc
     1441 cgtcaaaaaa tcaaaccgtg gcaaagttgt tgcggtgggg ttaggtcgtc cgctgaagaa
     1501 tggcgatcgc gcacgcatgg aagtgaaaac cggcgaccag atcattttca acgatggtta
     1561 cggtgtgaaa acggagaaag tggacggtaa agagtatctg atcctctccg agtctgatgt
     1621 gttagcgatt gtagaataat ttgttgcagc aaaaggagga taacgaaatg gcagcaaaac
     1681 acgttctgtt ttcaaccgac gccagacaga aaatgcttag tggcgtaaat ttactggcca
     1741 acgctgtcaa agttacgctc gggcccaaag gtcgccatgt tgtgctcaat aaatcttatg
     1801 gtgcgccaac catcactaaa gatggtgtct ctgtcgccaa agagattgag ctcgccgata
     1861 aattcgaaaa catgggcgca caaatgctca aacaagtggc gtccaaagcc aacgatgaag
     1921 cgggcgatgg cactactaca gcaaccgtgt tggcccaagc gttgatcaat gaagggatga
     1981 aggcggtcgc cgctggcatg aaccccatgg atcttaagcg cggtatcgac aaagcagtct
     2041 ccgcagcggt cgagaaattg caccaactgg ccaaaccttg cagtgacacc caatcgatca
     2101 ctcaagtcgg tgccatttcc gctaatagcg atcacgcgat cggcgaaatc atcgcgcaag
     2161 cgatggagaa agttggccgc aatggtgtga tcacggttga agagggacaa gctctacaaa
     2221 acgagctctc ggtggttgaa ggtatgcaat ttgatcgcgg ttacctttcc ccttacttca
     2281 tcaaccaacc caaagcgggc tgtgttgagt tggagaatcc ctacgtcttg ctagtagaca
     2341 agaaaatcag ccacattcgt gaactgctac cgattttaga atccgtggct aaagcttccc
     2401 gttcgctgct gatcattgct gaagatgtgg atggcgatgc gcttgcgaca ttagtggtta
     2461 acagcatgcg tggcatcatt aaagtggcag cggtgaaagc gccaggcttt ggtgaacagc
     2521 gcaaagcaat gctcgaggac atcgcggccc tcactgctgg ccgagtgatt agcgaggaaa
     2581 taggtcttga gcttgaaaaa gtgacgctgg acgatctggg tagcgcgaaa aaagtcacca
     2641 tcaataaaga caataccacg attgtcgatg gcgctgccga gccaagtgcc ctccaagatc
     2701 gcatcgcgca gatccaacat caattggaac acaccacatc gcaatacgat cgggacaaat
     2761 tgcagcaacg cattgccaaa ctctctggtg gggttgctgt gatcaaaatt ggtgcggcaa
     2821 cagaagtgga gatgaaagag aaaaaagatc gcgtggatga tgcattgcac gccactcgcg
     2881 ccgcagtgga agaagggatt gtggccggcg gtggtgtcgc tctgctgaaa attgccaacg
     2941 agctcagcaa tttacaaggt gataatgacg atcaaaatgt cggcattcgc attgcgctaa
     3001 gagcgatgga agaaccactg cgtcaaatcg ccatcaacgc aggggatgaa gcttcagtga
     3061 tcgcaaatca agtcaaaacg ggcgatgagc attacggcta caacgctgcc accggccaat
     3121 ttggcaatat gttagagatg ggcattttgg atcctgcgaa ggtgacacgc tcagcgctac
     3181 agtttgccgc aagcattgct ggcttgatga tcaccaccga agccatggtc agcgaagtag
     3241 acaaagagtc tgcggcgtaa tcgagtaagg tgaacagggc aaggagggcg aaatgactaa
     3301 actgcctcat ttacagttga gtgttgttga agcgcagcca aagactcatc cggccaatgc
     3361 ttggcctatg agtatgagct ttccgcagcg ctgccaagac agggtgctga tgccacctta
     3421 tcgtagcgtt ttccctactg tggtattggt ggtttacatc aatcaggctc agcagcaacc
     3481 tagcccgacc ttgcactgat gattgctgaa cttggtctaa gaggcagatt tttctgcctc
     3541 ttttttattg ctcgaatttc tattcaacaa gtacggagtt tacgccactt ttctcgctga
     3601 cgatggctgt gcaaagggca ttaacgcttg gtgcagcacg cacaccccgt ttgcgtaatc
     3661 tgcatcatcc accacaaact gcacattcac attacgcatc gaagagtgcg cggccatggg
     3721 ttgcaactgg tgttccagta acgcttgcaa tccttgggcg agcactttgt tggtttccat
     3781 gtgcgcaccg atcgctgaga tcagcgcaac cattcgccct gagactttcg cttgcggata
     3841 acgcttctcc gcttgatagc gaatgtgatt gagtggctcg ctgctgccac tcagataata
     3901 agtgactgag ttggcgttca tctctttacc gatcaactgc actttcgctg cgtggatcca
     3961 ttcaatcaat tcatggctga ctttatccat catcccgacc atgctttggt caaacagatg
     4021 caacgcaaac actttatctc gtcctgcaat gatctccact ctatcttgct gcggctgatg
     4081 tgaggctgta attaacgtgc cagaatggtc aggttcaaag gtatttttga tccgcaaatc
     4141 gatattactt tgtcttaacc ctgctgccgc gttggggtgg atcgcctcca taccgagatt
     4201 agccaattga tccgccacat cgaaattggt taagccaatc gggcgcactt tttctgcgcc
     4261 gaccaggcgc ggatcggccg agctcaagtg atactctttg tggatgatgg cttgctgagc
     4321 gcccgtaacc accgcaattc gactaaatgt catttcgctg taaccgcgat cataggtgcg
     4381 catcaaccct tcttggcaag aagcgtagcc agtgacgatc ggcaactcac tcgtcacatc
     4441 aatatcgcga aacgcttctt caatcacctg atcgaggttg ccttgcgtcg cttcgcacca
     4501 accagacaaa tcgacaaagc gggcgttaac acctagtgtg ttgagcttca gtgctgtgtt
     4561 ataagcgctg tgcgattcac cgagcgaggc aagaaactca cgaatttgcg gtaagtattg
     4621 gcgcagcgaa aactgcccat attggcaggt ttgcaaaatg ttttggatgc aggctatggc
     4681 ttcggctaaa cgagcacgaa taaatttatc cgcgcgtaaa cgcgtcattg catctgcaaa
     4741 catattttcg ttaatcagca gcatgcgctg ttctagggcg taaactgcat cacgccaact
     4801 ctcatcatgc ttggctattt tttggtaaat cccaggcgca ccagtgcgtt tgcattccag
     4861 taaggcatcg gtcatgcccg aataagccga gaccacaaat actcgaccat agggctgctc
     4921 gggcctgagt aaaatatttt ccaataccgc atcaaaagcg gtcatcgaag taccaccgat
     4981 tttctctacg gtgtaagaca tcatttctcc ttatgacatt gtgacattaa ttcactttta
     5041 tccagcggat agacaccttc cgcatcatga atttcgtgtc cagtgagtgg cggattaaag
     5101 acgcacgcca tcaccatctc gtttgaaaag gcgcgtaagt agtgttcatc atgctgatct
     5161 aggatgtaca aggttcctgg ttggatcgga tacgttttac cacccacaac ctcaatttcg
     5221 ccttcacccg acatgcagta cactgattcg aggtggttgc ggtagtgaat atgcgtctgg
     5281 gtgtttgcgt agatggtcgt gatatgaaaa gagaacccca tatggtcatc tttcaataac
     5341 atacgcacac tttcccagtt ttctgccacc actcgacgtt cactttggcg gcactgctct
     5401 agcgttcgaa caatcatgtt ttctccttat ttttgtgctt gtttcggatg agtcaggagg
     5461 cttgctgcaa tccacgcggt gctattcgag cagcacagcg ctcaataatg gtcaatccgt
     5521 gcgcgagatc cgcttcggtt atggtgaggg ggcaaaacac tttcagcacc tcatcttctg
     5581 cacccgcagt ttcaataatc aacccttttt gaaaacagat cgcggcaatc tcgcgggcaa
     5641 tgtccccatt atggcaagcc agaccttgca ttaagccgcg tccttttagg ccagaaaata
     5701 acgtcggata acgactcaaa cactgcagca atgcctgagt cacttgctca ctgcgtgcgg
     5761 caatatgggt ttgaaaatcc tcattcgccc agtaggcttc tagcgcgcga gtggcggtga
     5821 caaaagcatg gttattgcca cgaaaagtcc cgttgtgctc tcctggtttc cattgatccc
     5881 actcgggctt aaacagcact aatgccatgg gtagtccgta accgctgagc gatttcgata
     5941 aggtcaccat atccggctcg atgccgcttg gctcgaaact aaagaacgtc cccgtacggc
     6001 cacaacctgc ttgaatatca tccacaatca acaaaatttg ctgagcacgg cagatcgcct
     6061 gtaaacgttg taaccaagcg tccgaagcaa cgttcaaacc tccctcgcct tgtaccgttt
     6121 ccagtaatac cgcggcaggc ttatctaaac cggacgagtt atcttgcaac atggtttcaa
     6181 acaaagtgag tccatcaacg ccagcgtaac catcataagg cacacgataa acgcctgaga
     6241 gtgctaaacc cgcgccttga cgatgatgct gattacccgt cgcggcaagc gccccgagtg
     6301 aacaaccgtg gaaaccattc gtaaatgtca cgacgttatg acgacctgtc actttgcgcg
     6361 ccaactttaa cgccgcttcg accgcattgg ttccggttgg gccagtaaac tgcagtttgt
     6421 agttcaatcc acgcggctca agaatgtgcg tttgtagcgc ctgaataaac tgcgctttgg
     6481 cttcagaatg catatccaat ccgtgagtta agccatcacg ttcgatgtac tcaaggagag
     6541 cttgtttgag gacagcatta ttgtggccat aattcagcgc gcccgcgccg gagagaaaat
     6601 ccagataagc gtcgccttgc tggctgtaaa gccaactgcc tttggcggtg ccaaatagca
     6661 ctggaaaatg attcgcgtaa gactgcactt gagattcgtg gtgtttaaaa atatccataa
     6721 ccagatttgt tatcctttag gtcagttcga tgattgaaga ggtatacgat agagatattc
     6781 cgtgtcgtgt tctccttcaa aatggcaggt ttcatccaaa aaagtggata cactgccctg
     6841 ctctccctgc tctctatcga gcttttgaaa cagccgccaa gacgcttgat tggagcgcgt
     6901 aatggtggtt tcaagaaccg tgatgtcggc taaatcttcg cgcgccagca gatgtttgag
     6961 catctgatag gctaaacctt taccgcgtgc actcgggtgc accgccactt gccaaataaa
     7021 caactcgttc tgctgttccg gcttgcgata cgcagaaaca aatccgacca acaactcttg
     7081 ctgttcagcc atcaaacatg ttgtttgaaa atgactggac tgcagaaagt tgcaataagc
     7141 tgaattctga tcgagcggcg cacactgcgc gatgagctca tgaatcgaca aaccatcttc
     7201 ctgtgttggc cgacgaaata cccacggcag cgcaggtttg tgcatgattt gcggataaat
     7261 catccaaggc gtagcggtaa acatcacaac aatttccttt gtgttcaaat taaatgccca
     7321 tttttaccct agcaggacaa gcagatattt caagcttaaa tcgcaaaaaa tacccatcca
     7381 aagctaaaga atcccttttt aaggaataaa aatactttga actgaaacat aaaatgaatt
     7441 ttaaaatacc gatgaaattg ataggcagcc agtgctaact cgcggattaa cacccaaacg
     7501 acttgacgtt gcaggtaggg gttaaatgac gaagagctca gatacacggt gtaattggtg
     7561 tgaacgaatg cggccagcac ggctaccgct tcacgtaaga aatggctatt ttcgatcttt
     7621 cagcccatac gaggatggat ttaacagagg tttgaagcgg attgcgagcc gttgcatttt
     7681 gcaattgcac aatgcaacca aatgaacagc aactccgcaa ggaatgcaca aaaaccacac
     7741 aaatacgtgc ctattaaact tggcacagat agtgcattta taggaatgac ccttaattaa
     7801 gccgagggtc acctagccaa ctgacgttgt tagtgaatga aattgttcac atttgtttta
     7861 tcagccaatc acccttttgt gattggcttt tttcttttta atccctgaac aactaaaaac
     7921 catttagcct gcaacattca aggtgtgaag gcgttttcca acgattatgt taaggcgtca
     7981 cacttcgcag cacagataaa atcatttttg tgtagacctt tgatagaatg actccaccaa
     8041 gtcacggtca cgttgcccca ttctaataaa atggccggat gatgaaattc ttgttctgcc
     8101 aattcagcaa tttgattaga gaatgcccac gcttgtttaa agtttttgaa gcgataccgc
     8161 ttttcaagtt gggcaatacc gtctcggtga attaatgccc aaccatccag ttcactgagc
     8221 agctgttgct gctcttctga tgtcaaaccg atagcgtctg cactgcacgc ttcacaacgt
     8281 aattcatcca gcatgttgtt gttcctttgg ttgaaaaaga ggcgggagta acccgtcttg
     8341 catagcttgc cacaccaagc ccatcacatc gcgttgactg agttgataca gttgactgag
     8401 atccggcaac acataataaa tcggctgcat aatatcaatg cggtaaggag tgcgtagcac
     8461 ttgcataata tcgaacggct cacgttttgg gattgtgctt tctgaagcgt aaagcgtttc
     8521 acccggtgac gacaaaatgc ccccgccata aattttggtt tgtccctgtt cttgaactaa
     8581 gccgaactca accgtaaacc agtacaaacg cgctaagtag ctacgctctt tgggggtggc
     8641 tttagcacct agctggccat aaacatgagt aaaagcggca aaatcagggt gcgtgagcat
     8701 agcgcagtga ccatacactt catggaagaa atccggctct tggagataat caaactcatc
     8761 tcgacgccgc aaaaacgtgg ccactggaaa cttcttatcg gcgagtaagg caaagaagcg
     8821 atcaaaactg atcaatgccg gaacaggctc aacttgccaa ccggtttctg tttgcaatac
     8881 tcggtttatt tccggcaatt gtggcaggcg atctgtcggc aaattaagca tattcaaacc
     8941 atctaaataa gcttggcagg ctctggtttt caccacctct tgctggcgag tgatcagctc
     9001 atgccaaacc gcatgctcat cctgatccca atcaatatga ccatgctcac tgacgggttt
     9061 agagtgatac tgagtcatcg ccctgctcct taacaaattc attacattaa gcctacctag
     9121 cccaatctga actgccaatg ggaccttgct caatcaagat aatatcgatg taacaataat
     9181 tttacaattg tgcacttttt agttattttt cataggcctg atcctgacca gtcaagttga
     9241 ctttcgaact tgcgaggaca aaacttgttc acagtgatca cgtcagaatt gatttttaga
     9301 cagggaatat tatgtcatcg actacaccat tgtggacgcc aagccacgag cgcatttccg
     9361 cttctaacct gcaacagttc atcgcacatg tgaacatgca aggtgaagcg atcgacagtt
     9421 attcttcgtt gcatcagtgg tctgttgctg aaacacgaca attctggctt gaggtgtggc
     9481 aattttgcga tgtgatcggc tatcgcggaa actgcattat tggtgaagga ctacctcgtt
     9541 ttggtaaaac catggttccc gctcgtgatt cgatctggtt tccacaagct cagctcaact
     9601 acgcagaaaa cctactctca tacgcattcc aaaatcccga tgggatcgcc ctctggttta
     9661 aaaatgaaaa tggccatacc aagaaattca gttggcagca gttgtgtgat catgtttccg
     9721 tcgttcaaca gtggttggca caaaatggcg ttggagaggg tgatgtcgtg gctggctatc
     9781 ttccccactt acccgaaacc gtgattgcca tgttagccgc caccagttta ggggcaatct
     9841 ggacttcgac gtcaccggat tttggcgtgg aaagtgtgat tgaacgcttt ggtcaagttc
     9901 aaccgaaaat tctgttttgt tgtaatggct acacgtttaa cggtaaatcg tttcccatgc
     9961 aagagcgtaa tgctcagata gctagcgccc tgccaagcct agtcaacacc tgtcaaatcg
    10021 aatatctgca agatcgcaac ttcacaccgg atttcaatga tagcttttct gactggcaat
    10081 cgattttcgc cagttatcaa ccgcgaggag tcgaataccg ccggattggt ttcaacgatc
    10141 cgctgtttgt tctgtattcc tctggaacaa cgggcaaacc gaaatgcatc acgcactccg
    10201 ttggcggtac gctactcaat catttgaaag agcatcagtt acactgtgat atccagccac
    10261 aagatcgcgt tttctattac acgacaacag gttggatgat gtggaactgg catgtctctg
    10321 cactcgccag tggcgcaacc ttagtgattt atgatgggca tccactctac ccacaagcgg
    10381 gagcgttatg ggctctggtt gacgaagcca aagtcag
//
