LOCUS       NZ_CP098034.1          10873 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP098034.1 Vibrio alginolyticus strain E110 chromosome 2,
            complete sequence.
ACCESSION   NZ_CP098034
VERSION     NZ_CP098034.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 13:42:47
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 41335
            Orig. end    :: 52208
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10873
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[46335:47208](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5873)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10873
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10873
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(1133..2074)
                     /gene_functions="regulatory (smcogs) SMCOG1125:LysR family
                     transcriptional regulator (Score: 256.2; E-value: 7.2e-78)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg2_32"
                     /transl_table=11
                     /translation="VNVEKLARIDLNLLVCFKVLIEELNVTRAAHRLCLSQSAVSKSLA
                     KLRIQFDDPLFTRNSHGLTPTPRALFLKPKLDLLINQLEVLTQPEEFSPQSSEYRFQIA
                     AVESVYPLILPHFLPAIFQQAPGVTISTHPWSDNTFKMLQRGELDLGLTGKDIDINDAK
                     LTLQPPDDICELEIYRDYQMCIIRKNHPALKQPWNLEAYLALRHVQVRCDGNDRWLLDY
                     RLADIGADRDIAVTVPDFNSAASLCSYTDFIFTAPSHFVQLAAKQLDLVVLPLPLEFPP
                     MAYTLFWHRDRENDPALGWLRTMITQKTDHLR"
     PFAM_domain     complement(1151..1789)
                     /aSDomain="LysR_substrate"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03466.22"
                     /description="LysR substrate binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_32_0002"
                     /evalue="1.20E-29"
                     /label="ctg2_32"
                     /locus_tag="ctg2_32"
                     /protein_end="308"
                     /protein_start="95"
                     /score="103.3"
                     /tool="antismash"
                     /translation="SSEYRFQIAAVESVYPLILPHFLPAIFQQAPGVTISTHPWSDNTF
                     KMLQRGELDLGLTGKDIDINDAKLTLQPPDDICELEIYRDYQMCIIRKNHPALKQPWNL
                     EAYLALRHVQVRCDGNDRWLLDYRLADIGADRDIAVTVPDFNSAASLCSYTDFIFTAPS
                     HFVQLAAKQLDLVVLPLPLEFPPMAYTLFWHRDRENDPALGWLRTMITQK"
     PFAM_domain     complement(1868..2044)
                     /aSDomain="HTH_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00126.29"
                     /description="Bacterial regulatory helix-turn-helix
                     protein, lysR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_32_0001"
                     /evalue="1.80E-15"
                     /label="ctg2_32"
                     /locus_tag="ctg2_32"
                     /protein_end="69"
                     /protein_start="10"
                     /score="56.7"
                     /tool="antismash"
                     /translation="LNLLVCFKVLIEELNVTRAAHRLCLSQSAVSKSLAKLRIQFDDPL
                     FTRNSHGLTPTPRA"
     CDS             2182..3375
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 92.1; E-value:
                     4.3e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg2_33"
                     /transl_table=11
                     /translation="VSSQFSNSKKQMALLTLLVLFSPLAIDIYLPALPLIASTFQVDNA
                     LAQDTITWFLFAMGVGQLFAGPLADKLGRRTVALGGITIYAMSALLAWSAQNIEWMLVS
                     RLLQGLGACATSVAAFATVRDIFGPEKSGKMISYLNGAICFIPALAPILGSWLTQQFDW
                     RANFSFMAGFAVVSGSLMFFMMKETNPSTEKQAVFKLSRYWAVLSTPSFVFHASLCLMA
                     MAVILAYVTSAPSVLMTGMGLSMNEFTFWFGVNAVINIAACMLAPKFMERVGTHNTLVT
                     GISTLGLAGVIMLVMNGQNTALSFMLPIFMSSVGFAFILGAAAGKALEPFGDKAGTAAA
                     LLGLFQMSGSGLLVGTLQRLSLDPQTLIAIHMWVLLPALVVLFTKAGKNWHSSFAKA"
     aSDomain        2206..3324
                     /aSDomain="TIGR00710"
                     /aSTool="tigrfam"
                     /description="efflux_Bcr_CflA: drug resistance transporter,
                     Bcr/CflA subfamily"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg2_33_0001"
                     /evalue="4.70E-70"
                     /identifier="TIGR00710"
                     /label="ctg2_33"
                     /locus_tag="ctg2_33"
                     /protein_end="381"
                     /protein_start="8"
                     /score="234.9"
                     /tool="antismash"
                     /translation="KKQMALLTLLVLFSPLAIDIYLPALPLIASTFQVDNALAQDTITW
                     FLFAMGVGQLFAGPLADKLGRRTVALGGITIYAMSALLAWSAQNIEWMLVSRLLQGLGA
                     CATSVAAFATVRDIFGPEKSGKMISYLNGAICFIPALAPILGSWLTQQFDWRANFSFMA
                     GFAVVSGSLMFFMMKETNPSTEKQAVFKLSRYWAVLSTPSFVFHASLCLMAMAVILAYV
                     TSAPSVLMTGMGLSMNEFTFWFGVNAVINIAACMLAPKFMERVGTHNTLVTGISTLGLA
                     GVIMLVMNGQNTALSFMLPIFMSSVGFAFILGAAAGKALEPFGDKAGTAAALLGLFQMS
                     GSGLLVGTLQRLSLDPQTLIAIHMWVLLPALVV"
     PFAM_domain     2227..3237
                     /aSDomain="MFS_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07690.18"
                     /description="Major Facilitator Superfamily"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_33_0003"
                     /evalue="5.10E-46"
                     /label="ctg2_33"
                     /locus_tag="ctg2_33"
                     /protein_end="352"
                     /protein_start="15"
                     /score="157.3"
                     /tool="antismash"
                     /translation="TLLVLFSPLAIDIYLPALPLIASTFQVDNALAQDTITWFLFAMGV
                     GQLFAGPLADKLGRRTVALGGITIYAMSALLAWSAQNIEWMLVSRLLQGLGACATSVAA
                     FATVRDIFGPEKSGKMISYLNGAICFIPALAPILGSWLTQQFDWRANFSFMAGFAVVSG
                     SLMFFMMKETNPSTEKQAVFKLSRYWAVLSTPSFVFHASLCLMAMAVILAYVTSAPSVL
                     MTGMGLSMNEFTFWFGVNAVINIAACMLAPKFMERVGTHNTLVTGISTLGLAGVIMLVM
                     NGQNTALSFMLPIFMSSVGFAFILGAAAGKALEPFGDKAGTAAALLGLFQMSGSGL"
     CDS             3467..3748
                     /locus_tag="ctg2_34"
                     /transl_table=11
                     /translation="MSLTTYEMARILEQMEDSPEKVMFGKLLNELGNQSSERIRSAAKQ
                     VPLPILRDIVYQFQQVIESRKDEQVEQMAKDLAQQGISAEELLAYLNK"
     CDS             complement(3780..4235)
                     /locus_tag="ctg2_35"
                     /transl_table=11
                     /translation="MTDTVKNLVNRYDDLISTLQAGFVPLLLLFCRLWVAWVFFNSGLI
                     KISSWDSTLYLFELEYQVPILPWELAAYLGTAAELVLPVFLALGLITRPMAAMLFVFNI
                     IAVISYPLLWEKGFYDHQLWGLMILIVIVWGPGPLSLDHILKKKMTS"
     PFAM_domain     complement(3912..4157)
                     /aSDomain="DoxX"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07681.14"
                     /description="DoxX"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_35_0004"
                     /evalue="1.20E-17"
                     /label="ctg2_35"
                     /locus_tag="ctg2_35"
                     /protein_end="108"
                     /protein_start="26"
                     /score="64.3"
                     /tool="antismash"
                     /translation="LLLFCRLWVAWVFFNSGLIKISSWDSTLYLFELEYQVPILPWELA
                     AYLGTAAELVLPVFLALGLITRPMAAMLFVFNIIAVI"
     CDS             complement(4246..5004)
                     /locus_tag="ctg2_36"
                     /transl_table=11
                     /translation="MNLATLQSQFAKALHYQALGEDCDIASDTFTADERMQIYRNNFIV
                     SLSEVLSATYPMVEALLGEECFEQIARQHVLSYPLEEGDVVHYGDGFQDTIMQFSQVIA
                     QAPYSPEVARFEWHIDLARQAQYEQSNAAALKPLALLGEVSEEQQPALVLHLKQGCRSF
                     DSSYAVFDLFSAIQTGQFEQLNINQLQQGVISIQANGEALCHALDADVFQLLQCLEQKQ
                     SLSEIPEVLLAHLNRIMALDIVDGFTLQSI"
     PFAM_domain     complement(4723..4989)
                     /aSDomain="DUF2063"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09836.11"
                     /description="Putative DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_36_0005"
                     /evalue="1.50E-21"
                     /label="ctg2_36"
                     /locus_tag="ctg2_36"
                     /protein_end="94"
                     /protein_start="5"
                     /score="76.5"
                     /tool="antismash"
                     /translation="LQSQFAKALHYQALGEDCDIASDTFTADERMQIYRNNFIVSLSEV
                     LSATYPMVEALLGEECFEQIARQHVLSYPLEEGDVVHYGDGFQD"
     CDS             complement(5001..5873)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg2_37"
                     /sec_met_domain="DUF692 (E-value: 5e-88, bitscore: 292.2,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VKHHTFHDLVGVGLRTPHLDYFSQNQPELSWLEIHSENYFQPNAT
                     ERHQLQTLREQYQISCHGIGLSLGSVERVSQKHLAQLKALIDSIDPILVSDHLSWSENG
                     GHYFNDLLPLPYTEEALNVFTRNVNEVQEYLQREILIENPSSYVKFQHSTISEWEFLTE
                     VQKRTDCRLLLDLNNVYVSAFNHGFDCDTYLDAIPADKVDEIHLAGFTIKQLDKGEIWI
                     DTHSRPVSDEVWQLFSQWTKKHGPRHTLIEWDLDIPAPEVLLGEAQKASQLLLQGTLPS
                     EQSEPRKAS"
     PFAM_domain     complement(5055..5846)
                     /aSDomain="DUF692"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05114.15"
                     /description="Protein of unknown function (DUF692)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_37_0006"
                     /evalue="1.50E-106"
                     /label="ctg2_37"
                     /locus_tag="ctg2_37"
                     /protein_end="273"
                     /protein_start="9"
                     /score="355.5"
                     /tool="antismash"
                     /translation="VGVGLRTPHLDYFSQNQPELSWLEIHSENYFQPNATERHQLQTLR
                     EQYQISCHGIGLSLGSVERVSQKHLAQLKALIDSIDPILVSDHLSWSENGGHYFNDLLP
                     LPYTEEALNVFTRNVNEVQEYLQREILIENPSSYVKFQHSTISEWEFLTEVQKRTDCRL
                     LLDLNNVYVSAFNHGFDCDTYLDAIPADKVDEIHLAGFTIKQLDKGEIWIDTHSRPVSD
                     EVWQLFSQWTKKHGPRHTLIEWDLDIPAPEVLLGEAQKASQL"
     CDS             complement(5973..6233)
                     /locus_tag="ctg2_38"
                     /transl_table=11
                     /translation="MKKSNLAVTAAVTGLLALGGTMLTAAPAVAAEKEKCYGVSKAGKN
                     DCATKSSSCAGTSKEDNQKDAFVVVPKGLCDKLAGGSTSSS"
     PFAM_domain     complement(5988..6137)
                     /aSDomain="DUF2282"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF10048.11"
                     /description="Predicted integral membrane protein
                     (DUF2282)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_38_0007"
                     /evalue="8.00E-23"
                     /label="ctg2_38"
                     /locus_tag="ctg2_38"
                     /protein_end="82"
                     /protein_start="32"
                     /score="80.3"
                     /tool="antismash"
                     /translation="KEKCYGVSKAGKNDCATKSSSCAGTSKEDNQKDAFVVVPKGLCDK
                     LAGGS"
     CDS             6515..8689
                     /locus_tag="ctg2_39"
                     /transl_table=11
                     /translation="MMDPSLLLDGLNDKQREAVAAPLENLLVLAGAGSGKTRVLVHRIA
                     WLMSVEQASPFSIMSVTFTNKAAAEMRGRIEELMMGSAGGMWNGTFHGICHRILRAHYL
                     DAKLPEDFQIIDSDDQQRLLKRLIKAQNLDEKQWPARQVAWWINGKKDEGLRPSHIDAY
                     HDPVTKTYLQLYTAYQEACDRAGLVDFAEILLRAHELLRDNKFVREHYQARFKHILVDE
                     FQDTNNIQYAWLRMMAGPECHVMIVGDDDQSIYGWRGAKVENIEKFTLEFPSVNTIRLE
                     QNYRSTKTILEASNTLIANNTERMGKELWTDGVVGEPISVYSAYNELDEARFAVNKIKE
                     WQDKGGALNDAAMLYRNNAQSRVLEEALIQAGLPYRIYGGMRFFERQEIKDALSYMRLI
                     ANRNDDAAFERVVNTPTRGLGDKTLETIRFAARDRGCTMWEASVAMLDEKVLAGRAAGA
                     LSRFIELVTALEDDTLEMPLHHQTDHVIKYSGLFAMYEQEKGEKSKARIENLEELVTAT
                     RQFEKPEEAEDMSLLTAFLTHAALEAGEGQADEFEDAVQLMTLHSAKGLEFPLVFMVGV
                     EEGMFPSQMSAEEAGRLEEERRLCYVGMTRAMQKLYITYAEMRRLYGQDKYHKPSRFIR
                     ELPETCLDEVRMKAQVSRPSSSGRFSQTVVKESFNETGFTLGSRVMHPKFGEGTIINFE
                     GSGPQSRVQIAFNGEGIKWLVTAYARLEKL"
     aSDomain        6533..8680
                     /aSDomain="TIGR01075"
                     /aSTool="tigrfam"
                     /description="uvrD: DNA helicase II"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg2_39_0002"
                     /evalue="0.00E+00"
                     /identifier="TIGR01075"
                     /label="ctg2_39"
                     /locus_tag="ctg2_39"
                     /protein_end="722"
                     /protein_start="6"
                     /score="1324.2"
                     /tool="antismash"
                     /translation="LLDGLNDKQREAVAAPLENLLVLAGAGSGKTRVLVHRIAWLMSVE
                     QASPFSIMSVTFTNKAAAEMRGRIEELMMGSAGGMWNGTFHGICHRILRAHYLDAKLPE
                     DFQIIDSDDQQRLLKRLIKAQNLDEKQWPARQVAWWINGKKDEGLRPSHIDAYHDPVTK
                     TYLQLYTAYQEACDRAGLVDFAEILLRAHELLRDNKFVREHYQARFKHILVDEFQDTNN
                     IQYAWLRMMAGPECHVMIVGDDDQSIYGWRGAKVENIEKFTLEFPSVNTIRLEQNYRST
                     KTILEASNTLIANNTERMGKELWTDGVVGEPISVYSAYNELDEARFAVNKIKEWQDKGG
                     ALNDAAMLYRNNAQSRVLEEALIQAGLPYRIYGGMRFFERQEIKDALSYMRLIANRNDD
                     AAFERVVNTPTRGLGDKTLETIRFAARDRGCTMWEASVAMLDEKVLAGRAAGALSRFIE
                     LVTALEDDTLEMPLHHQTDHVIKYSGLFAMYEQEKGEKSKARIENLEELVTATRQFEKP
                     EEAEDMSLLTAFLTHAALEAGEGQADEFEDAVQLMTLHSAKGLEFPLVFMVGVEEGMFP
                     SQMSAEEAGRLEEERRLCYVGMTRAMQKLYITYAEMRRLYGQDKYHKPSRFIRELPETC
                     LDEVRMKAQVSRPSSSGRFSQTVVKESFNETGFTLGSRVMHPKFGEGTIINFEGSGPQS
                     RVQIAFNGEGIKWLVTAYARLE"
     PFAM_domain     6545..7330
                     /aSDomain="UvrD-helicase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00580.23"
                     /description="UvrD/REP helicase N-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_39_0008"
                     /evalue="5.20E-74"
                     /label="ctg2_39"
                     /locus_tag="ctg2_39"
                     /protein_end="272"
                     /protein_start="10"
                     /score="249.7"
                     /tool="antismash"
                     /translation="LNDKQREAVAAPLENLLVLAGAGSGKTRVLVHRIAWLMSVEQASP
                     FSIMSVTFTNKAAAEMRGRIEELMMGSAGGMWNGTFHGICHRILRAHYLDAKLPEDFQI
                     IDSDDQQRLLKRLIKAQNLDEKQWPARQVAWWINGKKDEGLRPSHIDAYHDPVTKTYLQ
                     LYTAYQEACDRAGLVDFAEILLRAHELLRDNKFVREHYQARFKHILVDEFQDTNNIQYA
                     WLRMMAGPECHVMIVGDDDQSIYGWRGAKVENIEKFTLEF"
     PFAM_domain     7346..8365
                     /aSDomain="UvrD_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13361.8"
                     /description="UvrD-like helicase C-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_39_0009"
                     /evalue="3.50E-82"
                     /label="ctg2_39"
                     /locus_tag="ctg2_39"
                     /protein_end="617"
                     /protein_start="277"
                     /score="276.8"
                     /tool="antismash"
                     /translation="IRLEQNYRSTKTILEASNTLIANNTERMGKELWTDGVVGEPISVY
                     SAYNELDEARFAVNKIKEWQDKGGALNDAAMLYRNNAQSRVLEEALIQAGLPYRIYGGM
                     RFFERQEIKDALSYMRLIANRNDDAAFERVVNTPTRGLGDKTLETIRFAARDRGCTMWE
                     ASVAMLDEKVLAGRAAGALSRFIELVTALEDDTLEMPLHHQTDHVIKYSGLFAMYEQEK
                     GEKSKARIENLEELVTATRQFEKPEEAEDMSLLTAFLTHAALEAGEGQADEFEDAVQLM
                     TLHSAKGLEFPLVFMVGVEEGMFPSQMSAEEAGRLEEERRLCYVGMTRAMQKLYITYAE
                     "
ORIGIN
        1 atacctgcga tttcaacggc gttcttcgcc gcttttggca ttaggcatgg gtcagcttta
       61 ctcaccacag atgcgccagc attttgtaga accaatttaa accatgcgtt acttgttgca
      121 gggtcaacca gtacattctt gccagttagg ttttctagtc gtgcttgcaa tgcttctggg
      181 tgatgaaccg tcacgccggc accaacatga gcgtcaaact cagcaggtag gcgagcagga
      241 tctaggaagt attccacgct tgagtctgag tgcagaatcg cgtgagaaag cagaactggt
      301 agacgtgata catctagacc acgaacgttg agcaaccaac agatagaatc aagtgctgtg
      361 atcactgcgc tgtctgcacc ggcttttttc acgagctctg cgatttcttg gcgtttgctt
      421 tcacttgatt gtccaactgt ttctgttgcc attaggcgaa catcagaaac cacaggagca
      481 gggcggtcgt gccacagttc atcaattggg ttgctatcga gaatcttaag ctcaagggta
      541 cctgcaagtt ttgcttgtgc catgtctagc caagcagagt tgtgcatgcg agggtcgatt
      601 gccacagacg cgccatttgc aagatggtct ttaatccaat ctagtgcagg ctcttcaatc
      661 aagtgacggt attcgaatag atcagcagga acctgctttg ttacttgtac tgtgtagcga
      721 ccatcaacaa agatagcggc tttgtctttg gtgattaccg cagcaccagc agaaccagta
      781 aagccagtta gccaatgtaa acgctcgttg tgcgctggta cgtattcgcc caagtactcg
      841 tcttcatgtg ggacaagtag ggcatcaata ttatgttgtg ctagccattc gcgaattgca
      901 ttcacgcggc tttgggtatc gttgtgcatc tgtgttattc cttcaaatta ccgctccttc
      961 atgctcaggt gtgggagctg tttccatctg cttcatgcag tttacgattc cattgaggtt
     1021 cgcaatcact tcaatagagt cggagtacaa ctaggccata gatgagccaa aaaggactac
     1081 gacagttaag ctactcattt tagccgctaa gcgcaaattg agcgcggtgt ttttatctaa
     1141 ggtgatcggt tttttgtgtg atcatcgtac gtagccagcc taatgcaggg tcgttttctc
     1201 tgtctcggtg ccagaataaa gtgtaagcca taggtgggaa ttctaacggt agtggcagca
     1261 cgaccaaatc aagctgtttg gccgcaagtt gcacaaaatg acttggcgca gtaaagataa
     1321 agtcggtgta tgaacataaa cttgcggcac tgttaaagtc gggcacggtg acggcaatat
     1381 cgcggtcggc gccaatatct gcaaggcgat aatccagcaa ccaacggtcg ttgccatcac
     1441 aacgtacttg tacatggcgt agggcgagat aggcttccag attccaaggt tgttttagcg
     1501 cagggtggtt tttgcgaatg atgcacattt ggtaatcacg ataaatttcc aactcgcaaa
     1561 tgtcatcggg tggttgaaga gtcagcttgg catcgtttat atcgatatct tttccagtta
     1621 agcctaaatc cagttcgccg cgttgaagca ttttaaatgt attatccgac cacgggtgtg
     1681 tgctaattgt cacgccaggt gcttgttgaa aaatcgccgg taagaaatgg ggtagaatga
     1741 gagggtagac actctctacc gctgctattt gaaaacggta ttcactgctt tggggagaaa
     1801 actcttcggg ttgagtcagc acttctaact gatttatcaa cagatccagt ttcggtttaa
     1861 gaaacaatgc gcgcggcgta ggtgttaatc catgtgagtt tcgagtgaaa agcgggtcat
     1921 caaattgaat gcgcagttta gccagtgatt tacttacggc agattggctt aagcacaatc
     1981 ggtgggccgc acgagtaacg tttaactctt caatcagcac tttaaagcag accaatagat
     2041 ttaaatcgat acgagccagt ttttcgacgt tcacagtgaa tttcctctga ggaataatgc
     2101 tcatgattat acatcatttc cattcatatc atcagatgat taagctttac ccaaagttct
     2161 ttatccaatt cggagtgttg tgtgtctagc cagttttcta atagtaaaaa acagatggcg
     2221 ttattgaccc ttttggttct tttcagtcct ttagcgattg atatttatct acctgcttta
     2281 cctcttattg cttccacttt tcaggtcgat aatgcgctag cacaagacac gatcacttgg
     2341 ttcttatttg ctatgggtgt tggtcagcta ttcgcaggtc ccctagcaga taaactcgga
     2401 cgtcgaactg ttgcattggg cggtatcacc atttacgcga tgagcgcttt attggcgtgg
     2461 agtgctcaaa atattgagtg gatgttggtt tcccgactgc tacaaggctt aggtgcgtgt
     2521 gcgacatcgg tagcagcctt tgcaacagtt cgcgatatct ttggcccgga aaaaagcggc
     2581 aaaatgatca gctaccttaa cggtgcgatt tgtttcattc cggctttagc tccaattcta
     2641 ggtagctggt taactcagca atttgactgg cgtgctaact ttagctttat ggctggtttt
     2701 gctgtggtgt ctggatcatt gatgtttttc atgatgaaag agactaaccc gtcaacagaa
     2761 aagcaagccg tgtttaagct tagtcggtat tgggcagtgc ttagcacacc atcttttgtt
     2821 ttccatgcgt cattatgctt gatggcgatg gcggttattc ttgcttacgt tacctcagca
     2881 ccgtcggtat tgatgacggg gatggggctg tcgatgaatg aattcacttt ctggtttggt
     2941 gtaaatgcgg tgataaacat tgcggcatgt atgctggcgc ctaagtttat ggagcgcgtt
     3001 ggaactcaca acaccttagt caccgggatc tcaactctgg gtctcgcagg tgtgatcatg
     3061 ctagtgatga atggtcagaa taccgcgctt tctttcatgt tacctatctt tatgtcttct
     3121 gtaggttttg cattcattct gggtgcagcg gcagggaaag cgttagaacc gtttggtgat
     3181 aaggcgggca cggcagctgc actgcttgga ttgttccaaa tgagtggctc tggtttgttg
     3241 gtgggtacac tgcaacgctt atctctggat ccacaaacct tgatcgcaat tcatatgtgg
     3301 gtcctattac ctgcgttggt cgttctgttt acaaaagcag ggaagaactg gcactcgagc
     3361 tttgcgaaag cgtaaatcag tgtaatttag tattttccaa tgtaagtaag gcgtgtatat
     3421 ttgtcactca gacttttcct gacaccataa cggaactcaa aaagtaatgt cgttaaccac
     3481 gtatgaaatg gctcgtattc tagagcaaat ggaagattca ccagaaaagg tgatgtttgg
     3541 caagttgctt aatgagctgg gtaatcaaag ctccgagcgt attcgtagtg cggctaaaca
     3601 agtacctctg ccaattttgc gtgatatcgt gtaccaattt cagcaagtga ttgagtcacg
     3661 caaagatgaa caagtcgagc agatggcaaa agacctcgct cagcaaggta tctcagcaga
     3721 agagctactg gcttacttga ataaataata aaaaatcccc gcatgatgcg gggatttttt
     3781 tagctcgtca ttttcttttt caggatgtgg tccaaagaca gcggtcctgg cccccatacg
     3841 attacgataa gaatcatcaa tccccaaagt tggtggtcat aaaaaccttt ctcccacaac
     3901 agtgggtaag agatcactgc gatgatgttg aacacaaaca gcattgctgc catcgggcgg
     3961 gtaatcaatc ccagtgccaa gaacaccggt agaaccaact ccgcagccgt acctaaataa
     4021 gccgccaatt cccatggcaa gattggcact tggtattcca gctcaaataa gtacagcgtg
     4081 ctatcccaag atgagatttt gattagtcct gaattgaaga acacccaggc tacccacaag
     4141 cgacaaaaga gaagtagtaa agggacaaag ccagcttgta gggtactgat taaatcgtcg
     4201 taccgattca ctaagttttt aaccgtatcc gtcatagagt gctccttaga ttgattgcaa
     4261 tgtaaagccg tcaacaatat cgagtgccat gatgcgattg agatgagcga gtaaaacttc
     4321 aggtatttcg ctcaaactct gcttctgctc taaacattgc agcagttgga acacatcggc
     4381 atcgagtgcg tgacacaagg cttctccatt ggcttgaatc gagatgacac cttgctgtaa
     4441 ttggttgata ttaagttgtt cgaattggcc agtttgaatc gcgctgaaca aatcaaatac
     4501 tgcgtagctg gagtcaaagc tgcggcagcc ttgtttaagg tgcaaaacca aagcgggttg
     4561 ttgctcctca ctcacttcgc caagtaacgc aagcggtttt aatgctgccg cattggattg
     4621 ttcatactgt gcttgacgag cgaggtcgat atgccattcg aagcgtgcga cttcagggct
     4681 gtaaggtgct tgtgcgatca cctgactaaa ctgcatgatg gtgtcttgaa agccgtcgcc
     4741 ataatgcacc acatctcctt cttctaatgg gtaagaaaga acatgctggc gagctatctg
     4801 ttcaaagcat tcttcaccaa gcagcgcttc aaccatcggg taggtcgcgg ataacacctc
     4861 gcttaagctg acgataaagt tattgcggta aatctgcatg cgttcatcag cggtaaacgt
     4921 atcactggca atatcgcaat cttcaccgag tgcttgatag tgtagggctt tagcaaactg
     4981 gctttgtaag gtggctagat tcatgatgcc ttccttggtt cgctttgttc acttggaagt
     5041 gtgccttgca acagtagttg cgatgctttc tgtgcttctc ctaataagac ttctggcgcg
     5101 gggatatcca aatcccattc aatcaacgta tgacgtggac cgtgtttttt tgtccactgt
     5161 gaaaacaact gccaaacttc atcgctaact gggcggctat gggtatcaat ccatatctca
     5221 cctttgtcga gttgtttaat ggtaaaacct gccaagtgaa tctcatccac tttgtcggct
     5281 ggaatcgcat ctaggtatgt gtcgcaatca aaaccgtggt tgaacgccga aacataaaca
     5341 ttgtttaaat cgagcaataa acgacagtca gtgcgctttt gcacttcggt aagaaactcc
     5401 cattcgctga tggtcgaatg ttgaaacttc acataactag atgggttctc tatcaagatc
     5461 tcgcgttgca aatattcctg cacttcattc acgttacgag tgaacacgtt gagcgcttct
     5521 tccgtatacg gaagtggaag caggtcatta aagtagtgac cgccgttttc actccaactt
     5581 aaatggtcag aaacaaggat tgggtcgatt gagtcaatca gtgctttaag ttgcgcaaga
     5641 tgcttttgac taacacgttc caccgaacct agcgacaaac caataccgtg gcagctaatt
     5701 tgatattgct cgcgaagcgt ttgtagctga tggcgctctg ttgcattggg ttggaaatag
     5761 ttttcactgt ggatttctaa ccaagacaac tcgggttggt tttggctaaa gtaatcgagg
     5821 tgaggagttc ttaatccaac tccaacaagg tcgtggaagg tgtggtgttt cacgtgaaac
     5881 tccttttcaa atcgtgcggg aagagaagga tgcgtcttgg ctttgcgttg gttgagcgtc
     5941 aacgcatcct cacaatagct agcgataaaa gattatgaag aagaagtgct accgccagcg
     6001 agcttgtcac aaagaccttt tggtacgact acgaatgcgt ctttttggtt atcttcttta
     6061 gaagtaccag cgcatgagct gctttttgtt gcacagtcgt ttttacctgc tttagaaacg
     6121 ccatagcact tttctttttc agcagcgaca gctggagctg cagttagcat tgtgccacca
     6181 agagctagaa gaccagtaac agcagcagta acagctagat tcgacttttt cataataaat
     6241 tcctctgaat gatttccttt actttaagtt ggcaagatga atcgcctgtt ttggcgtttt
     6301 tgttatcaac ttgcttaact taaaagatag gaaactggct aaaaaacttt cagaaaaatt
     6361 tctgaagtaa ataggtttgt agggtcaaat aggtataact aattgatgtg ttgggcaaaa
     6421 aaacatcaat ttttttatca agttttgtct aaacagcacc cggttgttta ggttataatc
     6481 ggtttttatg tataaataac cagtagctct catcatgatg gatccatctc tattactcga
     6541 cggtttgaac gataaacaac gtgaagccgt tgcagcacct ctagaaaact tgctcgttct
     6601 tgctggcgca ggaagtggta agacacgcgt tcttgttcac cgtatcgctt ggctgatgtc
     6661 ggtcgagcaa gcttctccgt tttcaatcat gtcggtaacc tttaccaata aggcggcggc
     6721 agagatgcgt ggacgtatcg aagagctaat gatgggcagt gcaggcggta tgtggaatgg
     6781 tactttccac ggcatttgtc accgtattct gcgtgcacac tatcttgatg cgaagctacc
     6841 ggaagatttc caaatcattg acagtgacga ccaacagcgt ctactaaagc gtttgattaa
     6901 agcgcaaaac ctcgatgaga agcagtggcc ggcacgccaa gtggcatggt ggattaacgg
     6961 taagaaagac gaaggtctgc gcccgtcgca cattgatgcg taccatgatc cagtaaccaa
     7021 gacatatctg cagttgtaca ccgcttacca agaggcgtgt gaccgtgctg gtttagtcga
     7081 ttttgcggaa atcttgctgc gcgcacatga gctactgcgt gataacaagt tcgtccgtga
     7141 acactaccaa gcacgcttta agcacatctt ggtcgatgag ttccaagata ccaacaacat
     7201 tcaatatgct tggctacgta tgatggcggg tcctgagtgt cacgtgatga tcgtaggtga
     7261 tgacgaccag tcgatttacg gctggcgtgg tgcaaaagtc gagaatattg agaagtttac
     7321 gctggaattc ccaagcgtga ataccattcg tcttgagcaa aactaccgtt ccactaagac
     7381 cattctggaa gcatctaaca ccctgattgc gaataacacc gagcgtatgg gtaaagagtt
     7441 gtggacggat ggcgtggtcg gtgagcctat ctcggtttac agcgcttaca acgaattaga
     7501 tgaagcccgt tttgcggtga acaaaatcaa agagtggcaa gacaagggcg gtgctctgaa
     7561 tgacgctgcg atgctttacc gtaacaacgc ccagtcgcgt gttctggaag aagcgttaat
     7621 tcaagccggt ctgccttacc gtatctacgg cggcatgcga ttcttcgaac gtcaggaaat
     7681 caaagatgcc ttgagctaca tgcgtctgat tgccaaccgt aacgatgatg cggcgtttga
     7741 acgtgtggtg aatacgccaa cgcgtggttt gggtgataag acgcttgaaa ccatccgttt
     7801 tgcggctcgt gaccgtggtt gcactatgtg ggaagcgagc gtggcaatgt tggacgagaa
     7861 ggtgcttgct ggtcgcgctg ctggtgctct gagccgtttt atcgagcttg tcaccgcgct
     7921 agaagacgac accttagaga tgccgctgca tcaccaaact gaccatgtaa ttaaatactc
     7981 gggcttgttc gcgatgtacg agcaagagaa gggtgaaaag tctaaggcac gtattgagaa
     8041 cttggaggaa ttggtgaccg caactcgcca attcgagaaa ccagaagaag ccgaagacat
     8101 gtcactgctg acggcattcc taacccacgc agcactagaa gcgggcgaag gacaagcgga
     8161 tgagtttgaa gatgcggttc agctcatgac attacacagt gcgaaaggtc tagagttccc
     8221 attggtgttt atggtcggtg tggaagaagg catgttccca agccaaatgt cggcagaaga
     8281 agcagggcgc ttagaagaag aacgccgtct gtgttacgta ggcatgaccc gtgcaatgca
     8341 gaaactgtac atcacttatg ctgaaatgcg ccgtttgtac ggtcaggata aataccataa
     8401 accgtctcgc tttatccgtg aactgccaga aacttgttta gatgaagtac gaatgaaggc
     8461 gcaagttagc cgtccttcaa gcagtggtcg atttagccaa actgttgtga aagagagctt
     8521 taatgaaacc ggctttacgc taggttctcg tgtgatgcat ccaaagtttg gtgaaggcac
     8581 catcatcaac ttcgaaggca gtggtccaca aagccgtgta cagattgcct ttaacggtga
     8641 aggcatcaaa tggttggtaa ctgcttacgc acgactagag aaactgtaag gcttgaccaa
     8701 aactcatacc aatcgtagta aataactggt cattctagct tgttaaaata ctcgataact
     8761 gcgttgcaat ttttgattgt agaataacta cttatcgaaa aattgcgcct tgttctcaag
     8821 cattttccct acgctatttc tgatcactta tttactgtga ttggtatcat caacttaaga
     8881 gctgcttcgg cggctctttt tgtttgtgcg gttttggtgt cgctaacgca gtaaaaaatg
     8941 gaatgataaa tggagtacaa aagcgcgact taacgatgcc gtttgaagtg aaaggtgggc
     9001 gttgtgggtg aatgcctgtt ttcagcagat ctactgagaa aaactttagg caaagaaaaa
     9061 ccccgagggc ttgcgcccat cggggttata gtcttactcg cagcaatcca gctactaaga
     9121 gtgctccatg catctaatcc atgatagtgt gctgaatccg tcagcttaat ccttacgtcg
     9181 ccttcctagc ggtgtcctta atgaccttat cctggtctgc taactatcct cgttagctct
     9241 catcacttgt tccctgagcg gtgtccctga catcatcctg atgttcaaat ccttgcctcg
     9301 tccagaggtg tccatttccc gtccttagta gcaaccatcc tagtcactat tgattccgtt
     9361 caatgtccaa ttttgcaatc catgcccgac tattcatcct gaataaccgt ttcttcttcc
     9421 tgaagttcac caagtccgtg gtgtttcctg ttccgtgtca gcatccttcc gacaggttta
     9481 atattacgtg tttaacgatt tccaacaacg ggctaatctc acatttttta actctcttag
     9541 cgttcaaaaa agatacatga gtattaaatt caatggctta tgctcttttc tgtacggttt
     9601 taccattaaa aaagagaggt ttgctcaacc ctttgtgaga gatctcgcac aaggggtcga
     9661 gcgaaagact cttactgccc gatagcggca ccttcacgtc ttggatccgc agcgccttca
     9721 agaccgtctt ttgttattcg tatcgcatgc agaccagagt tcaaatcccg aacatcggtt
     9781 ttaaagccca tcttctccag agcaggatgt aagccctctg cggcggtacc ttgctcaata
     9841 tctaaggtgc caaaacggtt cagcaatcgt ggctgattaa tcgcgctctg gatgtccata
     9901 tcccattgcg tgtgggcgat aatggcttgt gcgacgtaac caataatgcg gctgccaccc
     9961 ggtgagccaa ttgccatgta aggtttgtca tccttcatca taatggtcgg tgccatggag
    10021 gagcgtgggc gttttcccgg ttctaagcgg ttcgcgattg gcacaccatc ttgatgcgtg
    10081 cggaaagaga aatcggtcag ttcgttattg agcaagaagc cacgcaccat caagcgtgag
    10141 ccaaaggcgt tctcgatggt tgttgtcatt gaaaccacat tgccttgctt atcgacgata
    10201 ttgaaatggc tggtggaagg caactcgatc gattggtcca tgcttaagtc catggcgtgc
    10261 gaccaaggag gattaccggc ttcagcctta ctcaaggctt taccgacttg aatgagctca
    10321 gcacgttgtt tgagataatc tttatcaagc aagccttcgg ttggcattgg cacataatca
    10381 tggtcagcca tgtatttacc acgatctgcg aacgcaaggc gcgatgcatc agcgatcact
    10441 tgccatgatt tcgcgctttc ggctccccaa cctttaagat cgtattgctc ggtgatcgcg
    10501 agaatctgtc caaccgtcaa tgcgccagag ctaggtggtc ccatgccgca gatgttatag
    10561 ctttggtaag ccgcacaaac cggttcacgt tgcttgattt ggaacgcatc aaagtcaggt
    10621 tgtgccaata cgccaggatt gcccggtgca ttctgtactg tcttgatgat gtctgtggcg
    10681 atatcgcctt gatagaaagc ttttgcccct tgctctgcaa ttgccgtcag agtttgcgcg
    10741 tattcagggt tcttcaacaa cgtgccttcg gcttttggtg agccatctgg attgaagaag
    10801 taagccttag tcgcagggaa gcgagatagg cgcttggcat ctttttcaat cagactcgcg
    10861 aggcgaggac taa
//
