LOCUS       c00015_NZ_PYOV..       10716 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_PYOV01000003.1 Photobacterium angustum strain A2-4 CFSAN065426_3,
            whole genome shotgun sequence.
ACCESSION   NZ_PYOV01000003
VERSION     NZ_PYOV01000003
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 13:02:25
            Original ID  :: NZ_PYOV01000003.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10716
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10716
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[2208:5716]"
                     /cutoff="20000"
                     /detection_rule="IucA_IucC"
                     /neighbourhood="5000"
                     /product="siderophore"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2209..5716
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="IucA_IucC"
                     /neighbourhood="5000"
                     /product="siderophore"
                     /protocluster_number="1"
     cand_cluster    1..10716
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="IucA_IucC"
                     /kind="single"
                     /product="siderophore"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10716
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="siderophore"
                     /region_number="1"
                     /rules="IucA_IucC"
                     /tool="antismash"
     CDS             complement(663..2015)
                     /gene_functions="transport (smcogs) SMCOG1086:MATE efflux
                     family protein (Score: 224.2; E-value: 4.3e-68)"
                     /gene_kind="transport"
                     /locus_tag="ctg15_1"
                     /transl_table=11
                     /translation="MTYNKVTQGPIISTFFLFAFPALIALLAITTASLVDGIFVGKYLG
                     PQALAAINILIPYITFMFALGLMVAIGGTVTAGKFIGEGNYKEANGIFTLSLISIFLFA
                     TLMAIISLFFNESLFLFLGVDEQLTPLTQAYFQVISVVLTIQLTTMVLYYFVRADGFPT
                     LATTALVLGSVINIMLDVLFLGYFKWGIQSAAWATGIAQIIQLLVLCTFFTKKQRLIKF
                     QLCYSSVKPYFRGLLNGISEYINEISVGIVIFTIHWLLMKEQGNTAISGFAVANYMLFL
                     SMMLFYGIIDALHILVSQNYGARHFTRINQFMLLATVTVISISTLLIVSALSVSDLITK
                     LFIENTESDAYQLALSYIGVIWPCFIFSGINVLLSCYFTAMHCPLQSSIIALSRGLVLP
                     VSLLLLFTNFIPSIPFLFALPIAELSTFIIALTLYLRFQHNIKQKFELVTL"
     PFAM_domain     complement(825..1256)
                     /aSDomain="MatE"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01554.20"
                     /description="MatE"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg15_1_0002"
                     /evalue="2.00E-14"
                     /label="ctg15_1"
                     /locus_tag="ctg15_1"
                     /protein_end="397"
                     /protein_start="253"
                     /score="53.7"
                     /tool="antismash"
                     /translation="FTIHWLLMKEQGNTAISGFAVANYMLFLSMMLFYGIIDALHILVS
                     QNYGARHFTRINQFMLLATVTVISISTLLIVSALSVSDLITKLFIENTESDAYQLALSY
                     IGVIWPCFIFSGINVLLSCYFTAMHCPLQSSIIALSRGLV"
     PFAM_domain     complement(1473..1955)
                     /aSDomain="MatE"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01554.20"
                     /description="MatE"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg15_1_0001"
                     /evalue="1.50E-21"
                     /label="ctg15_1"
                     /locus_tag="ctg15_1"
                     /protein_end="181"
                     /protein_start="20"
                     /score="76.8"
                     /tool="antismash"
                     /translation="PALIALLAITTASLVDGIFVGKYLGPQALAAINILIPYITFMFAL
                     GLMVAIGGTVTAGKFIGEGNYKEANGIFTLSLISIFLFATLMAIISLFFNESLFLFLGV
                     DEQLTPLTQAYFQVISVVLTIQLTTMVLYYFVRADGFPTLATTALVLGSVINIMLDV"
     CDS             2209..3999
                     /gene_functions="biosynthetic (rule-based-clusters)
                     siderophore: IucA_IucC"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg15_2"
                     /sec_met_domain="IucA_IucC (E-value: 2.3e-62, bitscore:
                     205.7, seeds: 168, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMLTAKKIAEVASFQALFNCYLKECKQDSWYRVDAWMEKNELCCS
                     PPCQWVIEINLPIEHVVIAVEVTYKTIIGRHAFGDIWLKNNDENWYTISEKEAAITLLD
                     SFFEQKTMSLKKQELLIRLLESMSLMEYFLAENMTKNAPPSRCFIDAEQSLVFGHWQHP
                     TPKSRQGMLDFHHQYYAPELKGEFALHYFNVARSLICQRSALSISAEEIIASSLETADL
                     QISDEFIVLPMHPLQAQKLLHDPAILDLMTQGLIIDSGQHGCKFTATSSVRSLYSAHLS
                     WMYKFSIPVKITNSLRVNKRHELDAGVVMAGLYRKTGFSSDYPSFNVVTDPAYVTVLLP
                     EQEESGFETIIRENPFQAGQDQDVLTIAALTQDPLPNQASLLASIIVELATKKHCSESH
                     VAMRWFARYWDCAIDPMIRLYDEHGIALEAHQQNSVIQLESGYPSNYYFRDNQGFYLSK
                     SYRSYLEGMEPESSRVHDLYFDDEMICERFTYYLMINHLFSIIGRLGADHIIDEALLLN
                     FVKQRLTALHKSLLGGGKLFVEQLLTNKQWAMKANLLTRVHDVDELMVENEQAIYCYID
                     NPFITADTTNKKKEVSDAIA"
     PFAM_domain     2650..3324
                     /aSDomain="IucA_IucC"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04183.14"
                     /description="IucA / IucC family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg15_2_0003"
                     /evalue="1.10E-47"
                     /label="ctg15_2"
                     /locus_tag="ctg15_2"
                     /protein_end="372"
                     /protein_start="147"
                     /score="162.7"
                     /tool="antismash"
                     /translation="FIDAEQSLVFGHWQHPTPKSRQGMLDFHHQYYAPELKGEFALHYF
                     NVARSLICQRSALSISAEEIIASSLETADLQISDEFIVLPMHPLQAQKLLHDPAILDLM
                     TQGLIIDSGQHGCKFTATSSVRSLYSAHLSWMYKFSIPVKITNSLRVNKRHELDAGVVM
                     AGLYRKTGFSSDYPSFNVVTDPAYVTVLLPEQEESGFETIIRENPFQAGQDQDVLTIAA
                     LTQ"
     PFAM_domain     3415..3894
                     /aSDomain="FhuF"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF06276.14"
                     /description="Ferric iron reductase FhuF-like transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg15_2_0004"
                     /evalue="1.50E-34"
                     /label="ctg15_2"
                     /locus_tag="ctg15_2"
                     /protein_end="562"
                     /protein_start="402"
                     /score="119.9"
                     /tool="antismash"
                     /translation="RWFARYWDCAIDPMIRLYDEHGIALEAHQQNSVIQLESGYPSNYY
                     FRDNQGFYLSKSYRSYLEGMEPESSRVHDLYFDDEMICERFTYYLMINHLFSIIGRLGA
                     DHIIDEALLLNFVKQRLTALHKSLLGGGKLFVEQLLTNKQWAMKANLLTRVHDVDE"
     CDS             3986..5716
                     /gene_functions="biosynthetic (rule-based-clusters)
                     siderophore: IucA_IucC"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg15_3"
                     /sec_met_domain="IucA_IucC (E-value: 8.3e-72, bitscore:
                     236.6, seeds: 168, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPLPNCLTLEPEQRIIKQLFEAIMFEQLVEIDVGSENGHNTFTWI
                     MAEKHYHVRGHIGAFGRYRLDISTLTIDGQPQLISQSWEYIVRDLPALEQVKLSIIEEF
                     KQTSNLCRWNQDNIPARDSRRQASFIELEAQLDEGHPYHPSFKARTGFNFLDHQCYGPE
                     AGESFCLHWIAIKRTHFRSHLPEDHDCFWSSELDQDHWQTLSFILSQQQGNWQEYALLP
                     VHPWQWRQLHKEDFLSLLDQKIIIDLGELGDQYVASQSVRTLLNVTNQAKANIKLPLNM
                     VNTSSKRTLAGYSVCLAPEISTWLETIVSQDPELSGLDILVEYAGGIYVPLGKTVECDP
                     LSDQLAVIFRESLENKLSPEQTAVPFNALMMVEQDGQPFIDHWIDKYGLVPWLSQLIEV
                     AVIPIWHLLVKYGVGTEPHGQNMVLVHRNGWPEKIIIRDFHESVEYHSEFLSTEFPAPD
                     LALLEPTLAKAPLDIFYAMSSVELLRELVMDTLFIYNLVEVSHLIEWHYGGTERQFWQL
                     VENKLEQYSAAHPDLADRIAQLDYQSTSIATESLLARKFQAKKQECHHIVANALSCAFK
                     "
     PFAM_domain     4367..5095
                     /aSDomain="IucA_IucC"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04183.14"
                     /description="IucA / IucC family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg15_3_0005"
                     /evalue="3.70E-64"
                     /label="ctg15_3"
                     /locus_tag="ctg15_3"
                     /protein_end="370"
                     /protein_start="127"
                     /score="216.7"
                     /tool="antismash"
                     /translation="SFIELEAQLDEGHPYHPSFKARTGFNFLDHQCYGPEAGESFCLHW
                     IAIKRTHFRSHLPEDHDCFWSSELDQDHWQTLSFILSQQQGNWQEYALLPVHPWQWRQL
                     HKEDFLSLLDQKIIIDLGELGDQYVASQSVRTLLNVTNQAKANIKLPLNMVNTSSKRTL
                     AGYSVCLAPEISTWLETIVSQDPELSGLDILVEYAGGIYVPLGKTVECDPLSDQLAVIF
                     RESLENKLSPEQTAVPFNALM"
     PFAM_domain     5159..5653
                     /aSDomain="FhuF"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF06276.14"
                     /description="Ferric iron reductase FhuF-like transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg15_3_0006"
                     /evalue="1.60E-27"
                     /label="ctg15_3"
                     /locus_tag="ctg15_3"
                     /protein_end="556"
                     /protein_start="391"
                     /score="97.1"
                     /tool="antismash"
                     /translation="WLSQLIEVAVIPIWHLLVKYGVGTEPHGQNMVLVHRNGWPEKIII
                     RDFHESVEYHSEFLSTEFPAPDLALLEPTLAKAPLDIFYAMSSVELLRELVMDTLFIYN
                     LVEVSHLIEWHYGGTERQFWQLVENKLEQYSAAHPDLADRIAQLDYQSTSIATESLLAR
                     KF"
     CDS             5727..6983
                     /NRPS_PKS="Domain: AMP-binding (30-272). E-value: 1.6e-21.
                     Score: 68.2. Matches aSDomain:
                     nrpspksdomains_ctg15_4_AMP-binding.1"
                     /NRPS_PKS="type: NRPS-like protein"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score: 66.2;
                     E-value: 3.1e-20)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg15_4"
                     /sec_met_domain="AMP-binding (E-value: 1e-12, bitscore:
                     42.3, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIYVNDDYIDSAFFSQCFQIFSAHPQLKDCAGKRVAVCLQNPAQL
                     LALCLYLKRNGGSFYPILATTPRLAAKRLADKANCHIVIFDIEQTGLTLKREDKDQQAV
                     LVQTSSGTTGEPKVITRSWLSIDEEIESYVTTFTTPQSMTPLIACPITHSYGLICGVLV
                     ALKRDLVPVIITNINPKYLLRKCLENSDHLLYSSPSLLHSLVQLYPKQEQLHAVMTSGT
                     VLPQAWFEAIKVRSQYLFQQYGCSEAGCIAVCENPDYANQMGFPLPHLRVSAGSDVTSP
                     QEIIVSKNKLDINTQDLGFFDVQGQLCFVSRSDDMINVSGLNVYPQDVENVVMELAEIT
                     DAVVFKRADELSGERVCLQFVADTMIEPSRIRQWCGTRLANHQLPVDIEQREIIEKGAN
                     GKINRKVLSQSSVSIAAIG"
     aSDomain        5817..6542
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg15_4_AMP-binding.1"
                     /evalue="1.60E-21"
                     /label="ctg15_4_AMP-binding.1"
                     /locus_tag="ctg15_4"
                     /protein_end="272"
                     /protein_start="30"
                     /score="68.2"
                     /specificity="consensus: X"
                     /tool="antismash"
                     /translation="AGKRVAVCLQNPAQLLALCLYLKRNGGSFYPILATTPRLAAKRLA
                     DKANCHIVIFDIEQTGLTLKREDKDQQAVLVQTSSGTTGEPKVITRSWLSIDEEIESYV
                     TTFTTPQSMTPLIACPITHSYGLICGVLVALKRDLVPVIITNINPKYLLRKCLENSDHL
                     LYSSPSLLHSLVQLYPKQEQLHAVMTSGTVLPQAWFEAIKVRSQYLFQQYGCSEAGCIA
                     VCENPDYANQMGFPLPHLRV"
     PFAM_domain     6018..6542
                     /aSDomain="AMP-binding"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00501.30"
                     /description="AMP-binding enzyme"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg15_4_0007"
                     /evalue="5.00E-15"
                     /label="ctg15_4"
                     /locus_tag="ctg15_4"
                     /protein_end="272"
                     /protein_start="97"
                     /score="55.1"
                     /tool="antismash"
                     /translation="DKDQQAVLVQTSSGTTGEPKVITRSWLSIDEEIESYVTTFTTPQS
                     MTPLIACPITHSYGLICGVLVALKRDLVPVIITNINPKYLLRKCLENSDHLLYSSPSLL
                     HSLVQLYPKQEQLHAVMTSGTVLPQAWFEAIKVRSQYLFQQYGCSEAGCIAVCENPDYA
                     NQMGFPLPHLRV"
     CDS_motif       6651..6716
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg15_4_0001"
                     /evalue="8.30E-05"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg15_4"
                     /protein_end="330"
                     /protein_start="308"
                     /score="15.3"
                     /tool="antismash"
                     /translation="FVSRSDDMINVSGLNVYPQDVE"
     CDS             6993..8267
                     /locus_tag="ctg15_5"
                     /transl_table=11
                     /translation="MQREEMIQAIKKVLEENMQNSHMALFSPSAKLNEELYLDSVLILQ
                     LILHLELDLGLTVPEQHITAADYATVASLADFLCQVNNESELAPKEPEVEFEDVKVHCF
                     VSCVCEALKSKGIDHRPFYFAVWDATFDVSERYQLQYHSDDINHQLFIDWYQRLFGGEL
                     IAWYDSEKTKHANLATMRALLGNKSNSEHLMVMLDLYHLPERENKFNQNPFPHYVMLTE
                     TETPDHWMMWDPDFRWQGEISQDRIENAVSQPTVEGGYIFNENALQDAPLNVVQDYFKL
                     CFIEDENPLTNAVREIIQAHLDEKQGISLSDLPLALRELKVIAVRKYAYEHGFAYFGRA
                     LGQSDDDFEYWCDVIEELIQTYTSIQYQVMKMAETKDLNLYTGIQYLLDKQDRTEKRIK
                     KGLFDMYSDWCELNDLPCDSIMEVY"
     PFAM_domain     7284..8237
                     /aSDomain="DUF6005"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF19468.1"
                     /description="Family of unknown function (DUF6005)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg15_5_0008"
                     /evalue="4.20E-143"
                     /label="ctg15_5"
                     /locus_tag="ctg15_5"
                     /protein_end="415"
                     /protein_start="97"
                     /score="476.3"
                     /tool="antismash"
                     /translation="DVKVHCFVSCVCEALKSKGIDHRPFYFAVWDATFDVSERYQLQYH
                     SDDINHQLFIDWYQRLFGGELIAWYDSEKTKHANLATMRALLGNKSNSEHLMVMLDLYH
                     LPERENKFNQNPFPHYVMLTETETPDHWMMWDPDFRWQGEISQDRIENAVSQPTVEGGY
                     IFNENALQDAPLNVVQDYFKLCFIEDENPLTNAVREIIQAHLDEKQGISLSDLPLALRE
                     LKVIAVRKYAYEHGFAYFGRALGQSDDDFEYWCDVIEELIQTYTSIQYQVMKMAETKDL
                     NLYTGIQYLLDKQDRTEKRIKKGLFDMYSDWCELNDL"
     CDS             8269..9108
                     /locus_tag="ctg15_6"
                     /transl_table=11
                     /translation="MQLSICTISFRHQLMSLDHLAQWARSHDFQGIELWGVHAISLESQ
                     PQYDAQWLKEMGLSISMLSDYLPLVGDPIVSQQKCAHICKLANYWNTNKVRTFAGHQAS
                     DKVNKNDREKLVTRLRHICEYAHQQGLNVLVETHPNTLADTTESILQLLDEVYHPALKI
                     NFDSLHVWESGADINYFHNQISDFVDHYHLKNIASREYLNVFSPDNVYSPAGSREGMTP
                     LFEGALDYQHFIDGLSQNKNATASLEWFGNNVKQTLINDKKALDKFSKNIKQAELLF"
     PFAM_domain     8332..9027
                     /aSDomain="AP_endonuc_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01261.26"
                     /description="Xylose isomerase-like TIM barrel"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg15_6_0009"
                     /evalue="2.50E-21"
                     /label="ctg15_6"
                     /locus_tag="ctg15_6"
                     /protein_end="253"
                     /protein_start="21"
                     /score="76.6"
                     /tool="antismash"
                     /translation="QWARSHDFQGIELWGVHAISLESQPQYDAQWLKEMGLSISMLSDY
                     LPLVGDPIVSQQKCAHICKLANYWNTNKVRTFAGHQASDKVNKNDREKLVTRLRHICEY
                     AHQQGLNVLVETHPNTLADTTESILQLLDEVYHPALKINFDSLHVWESGADINYFHNQI
                     SDFVDHYHLKNIASREYLNVFSPDNVYSPAGSREGMTPLFEGALDYQHFIDGLSQNKNA
                     TASLEWFGNN"
     CDS             9241..9948
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 102; E-value: 6.1e-31)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg15_7"
                     /transl_table=11
                     /translation="MNIDKVHHSRTILIVEPDHNYGQQLIELFWREGFVIKRCQSALEA
                     ENVYKNAIVDLMLVSNQLPEMKGFTFLKQCRQVSHIPIVLLADNYSDTECVNSFFHGVD
                     DYIPRKQPIKEVLCRVIAILRRIQQRQLPSNKTKLLIVDDLKMDKQSLAVSYKETTLSM
                     TPIQFNLLWTLAFQQNQVLSKDYLYRQVLSREFSLYDRSLDMHLSRVRRKLVSAGMPVE
                     RLKTAHGVGYSFN"
     PFAM_domain     9274..9588
                     /aSDomain="Response_reg"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00072.26"
                     /description="Response regulator receiver domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg15_7_0010"
                     /evalue="5.80E-11"
                     /label="ctg15_7"
                     /locus_tag="ctg15_7"
                     /protein_end="116"
                     /protein_start="11"
                     /score="42.6"
                     /tool="antismash"
                     /translation="ILIVEPDHNYGQQLIELFWREGFVIKRCQSALEAENVYKNAIVDL
                     MLVSNQLPEMKGFTFLKQCRQVSHIPIVLLADNYSDTECVNSFFHGVDDYIPRKQPIKE
                     V"
     PFAM_domain     9718..9942
                     /aSDomain="Trans_reg_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00486.30"
                     /description="Transcriptional regulatory protein, C
                     terminal"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg15_7_0011"
                     /evalue="4.40E-15"
                     /label="ctg15_7"
                     /locus_tag="ctg15_7"
                     /protein_end="234"
                     /protein_start="159"
                     /score="55.6"
                     /tool="antismash"
                     /translation="TLSMTPIQFNLLWTLAFQQNQVLSKDYLYRQVLSREFSLYDRSLD
                     MHLSRVRRKLVSAGMPVERLKTAHGVGYSF"
ORIGIN
        1 ttaaggtctc taaagggttg ttgaagacta caacgttgat aggtcgggtg tgtaagtgct
       61 gtgaggcatt gagctaaccg atactaattg cccgtgaggc ttaaccatac aacacccaag
      121 gggtttttat ctcgtaaaga gaaaagcgga ctccaagtac acttgaacgt gtagagaaca
      181 ctagttactt tcccagattg ctatttattg tcgatgacaa taaataaaac cgaatttgct
      241 tggcgaccat agcgttatgg acccacctga tcccatgccg aactcagtag tgaaacgtaa
      301 tagcgccgat ggtagtgtgg ggcctcccca tgtgagagta ggacatcgcc aggctttaaa
      361 tttaagatat tcgttttgaa ctacggatat cggataaaac gaaagtttta tctccgtgtg
      421 gagcggtagt tcagttggtt agaataccgg cctgtcacgc cgggggtcgc gggttcgagt
      481 cccgtccgct ccgccactta tattaagccc tagtcgaaag actagggctt tttttagtct
      541 gtagaaagtg gaaatgatag tgtgaagtta agctttttat aaagaagctt aggcaagtcc
      601 cgtaacctcg actacctgtt taagaactca gtcgtttttt atgacctgat agctgataag
      661 gatcatagag ttaccagctc aaacttttgt tttatgttgt gttggaaacg aaggtaaagc
      721 gttaatgcaa taataaaagt acttaactct gcgataggta aagcaaaaag aaacgggatg
      781 cttggaataa aatttgtgaa gagtagaagt agtgatacag gtaaaactaa ccctcttgat
      841 aaagcgataa tagatgattg aagaggacaa tgcatcgctg tgaaataaca agatagtaag
      901 acatttattc cgctaaagat aaaacagggc catataacgc caatataact taatgccaat
      961 tgataggcgt cagactctgt attttcaatg aaaagcttcg ttattaaatc tgatacagac
     1021 agcgcactta ctattaatag tgtactaata cttatcacgg taacggtagc taaaagcatg
     1081 aattgattga tgcgtgtgaa atgtcttgct ccatagtttt ggcttaccag tatatgaagc
     1141 gcatcgataa tgccgtaaaa cagcatcatg ctaagaaata acatatagtt tgcgacagcg
     1201 aagcctgaga tagcggtatt gccctgctct ttcatcaata gccaatgaat agtgaaaata
     1261 acaataccga cagaaatttc attgatatat tctgaaatcc cattaagcaa ccctctgaag
     1321 taaggcttca cgcttgaata acagagctga aatttaatca atctttgttt cttagtgaaa
     1381 aaagtacaga ggactaatag ctgtattatc tgtgctatac ctgttgccca agcggccgat
     1441 tgaattcccc acttaaaata gccaagaaaa aggacatcaa gcatgatatt aatgacagag
     1501 cccaagacta aagctgttgt tgctagcgtt ggaaagccat ctgcgcgtac aaaataatat
     1561 aaaaccattg tggttagttg aatggtgagt acgactgata ttacttggaa gtaagcttga
     1621 gtaaggggag ttaattgttc atcaacacca agaaataaaa ataaactctc attgaaaaat
     1681 aaactaataa tcgccatcaa ggtagcgaat aaaaaaatag agattaacga taaggtaaaa
     1741 ataccattag cctctttata gtttccttct ccgataaatt ttcctgcagt aactgtccca
     1801 ccaatagcta ccattagacc caatgcaaac atgaatgtga tgtagggaat aagaatattg
     1861 atagcagcta aagcttgagg acccagatat ttacctacaa agatcccatc gaccaaactt
     1921 gcagtagtaa tagcaagtaa tgcaatgagt gcaggaaaag caaacaggaa aaaagtacta
     1981 atgatagggc cttgagtgac cttgttatac gtcatgattt ttatgtttta tgaatgagct
     2041 taattatcca ttttgaagcg tttcaatcat aagtacgagc gttgaagtgc cacggtttgc
     2101 ttccgcatac atttttgtgt aacaaatgta atcattgttg aaatgagaat taatatcatt
     2161 aagaatctct aactaatttc ttatttatca ataaatagtc ggttcaacat gatgttaaca
     2221 gcaaaaaaaa tagctgaagt cgcttcattt caggccctct ttaattgtta cttaaaagaa
     2281 tgtaagcaag attcatggta ccgagttgat gcgtggatgg agaaaaatga attatgttgt
     2341 tcaccaccgt gtcagtgggt tattgaaata aacttgccta tagaacatgt agttattgcc
     2401 gttgaagtga cttataaaac cattattggt cgccatgctt ttggtgatat ttggttaaaa
     2461 aataatgatg aaaattggta taccatctct gaaaaagaag ctgcaattac gcttttagat
     2521 tcattttttg agcaaaagac aatgtcactg aaaaaacagg aactattgat tcgcctgtta
     2581 gaaagtatgt cgctcatgga gtattttttg gcggaaaata tgacaaaaaa tgcaccgcct
     2641 tctcgttgtt ttattgatgc tgaacagagt ttagtttttg gacattggca acatccgacg
     2701 cctaaaagtc gtcaagggat gcttgatttt catcatcaat attatgcgcc tgaattaaaa
     2761 ggggagtttg cacttcatta ctttaatgtt gcccgctctt tgatttgcca gcgctcagca
     2821 ttatcaattt cagctgaaga gatcattgct tcttctctcg aaaccgcaga cttacaaatt
     2881 tcagatgagt ttatagtctt gcctatgcat ccgctgcaag cgcaaaaatt attacatgat
     2941 cccgctattc tggatttaat gactcagggg ctaattattg atagcggaca gcatggttgt
     3001 aagttcacag caacgtcctc tgtgagatcg ctatacagtg cgcatttatc ttggatgtat
     3061 aagttttcga tacctgtaaa aattacgaat tctcttagag taaataaacg tcatgaactt
     3121 gatgctggcg tagttatggc tgggttatat cgtaagacgg gatttagtag tgattatcct
     3181 agctttaatg ttgtgacaga tcctgcatac gtcaccgtat tattaccaga gcaagaagaa
     3241 agtggttttg aaactattat tcgagaaaat ccatttcagg cgggtcaaga tcaggatgtt
     3301 cttactattg cagcattgac acaagatcca ctgccaaatc aagcatcgtt attagcctct
     3361 attattgttg agttggcaac gaaaaagcat tgctctgaat ctcatgtagc gatgcgatgg
     3421 tttgcccgtt attgggattg tgcgatagat cctatgatcc gtttgtatga tgagcatggc
     3481 attgcgttag aagcacacca acaaaatagc gttattcaat tagagagtgg atacccatcg
     3541 aattattatt tccgagataa tcaaggtttc tatttatcaa aaagctatcg tagttattta
     3601 gaaggtatgg agcctgaatc tagccgtgtc catgacttgt attttgatga tgaaatgatc
     3661 tgtgagcgat tcacttatta tttaatgatc aaccatctct tttcgattat tggtcgacta
     3721 ggcgctgatc atattattga tgaagcttta ttactgaatt ttgttaagca acggctcacc
     3781 gcattacata aatcattact gggtggcggt aaattatttg tcgagcaatt gctgacaaat
     3841 aagcaatggg caatgaaagc gaatttactg acacgtgttc acgatgtcga tgaattaatg
     3901 gttgagaacg aacaggcgat ttattgctac atcgataatc catttataac agctgatacc
     3961 acaaataaga aaaaggaggt atcagatgcc attgcctaat tgtcttacgc tagaacctga
     4021 acagagaatc attaagcaac tttttgaagc catcatgttt gaacaattgg ttgaaattga
     4081 tgttggctct gagaatggtc acaacacgtt tacttggatc atggcggaaa agcattatca
     4141 cgttcgtggt catattggcg cttttgggcg ttatcgttta gatatttcaa ccttaacgat
     4201 tgatggtcag cctcagctta tctcgcaatc ttgggaatat attgttcgag acttgcccgc
     4261 ccttgagcaa gttaagttat ctattatcga agagtttaaa caaacctcca atttgtgtcg
     4321 ctggaatcaa gacaatattc cagctcgtga ttcacgtcgg caggcaagtt ttattgagtt
     4381 ggaagcacag cttgatgaag gacatcctta tcacccatct tttaaagcgc gaacagggtt
     4441 taactttctt gatcatcaat gttatgggcc tgaagctggg gaatcatttt gtttgcactg
     4501 gatcgcgata aaaagaacac attttcgttc acatttacct gaggatcatg attgtttttg
     4561 gtctagtgaa ttagatcaag atcactggca aacattgagt tttattttat ctcagcagca
     4621 aggaaactgg caggagtatg ctttattgcc tgttcatcct tggcagtggc gtcaattaca
     4681 caaagaagac tttctatctt tacttgatca gaaaattatt atcgatttgg gagagttagg
     4741 ggaccaatat gtcgcctcgc aatcggtcag aactttactc aatgtgacga atcaagcaaa
     4801 agccaatatc aaattgccat tgaatatggt gaacacctct tctaagcgga ccctagctgg
     4861 ttattccgtt tgtttggcgc cagagatatc aacatggctt gaaaccattg ttagtcaaga
     4921 ccctgagttg tcaggtttag acatattagt cgaatacgct ggcgggattt atgtaccgtt
     4981 agggaaaacg gtagagtgtg atcctttaag tgaccaactg gcggttattt ttagagaaag
     5041 cctagaaaac aaattatcac ctgagcaaac ggcggtacca tttaatgcgt tgatgatggt
     5101 cgagcaagat ggtcagccat tcattgatca ttggattgat aaatatggct tagtgccgtg
     5161 gctctcgcaa cttattgagg tggcagtgat cccaatttgg cacttattgg tcaagtatgg
     5221 ggtggggacg gagccgcacg gacaaaacat ggtattggtt caccgcaatg gttggcctga
     5281 aaagattatt attcgtgatt ttcatgaaag tgttgaatac cactctgagt tccttagtac
     5341 tgagtttcca gcacctgatt tagcattatt agaaccaacc ttagccaagg cacctctaga
     5401 tatattttat gccatgagtt cggtagagct gctgcgcgaa ttagtgatgg ataccttatt
     5461 catttataac ctcgtagagg tctctcacct tattgaatgg cattacggtg gaacggaaag
     5521 gcagttctgg caactggttg agaataagct cgaacaatac agtgcagcgc atccagatct
     5581 cgcagatcgg atcgctcaac tcgattatca atctacttca attgcaacag aatcattatt
     5641 agctcgaaaa tttcaggcta agaaacaaga gtgtcaccat atcgtggcga atgcgctttc
     5701 gtgcgctttt aaataatagg gatattatga tttacgttaa tgatgattat atcgatagtg
     5761 cttttttctc acagtgtttc caaatatttt cagcgcaccc tcagttaaaa gattgtgcag
     5821 gaaaacgcgt tgccgtgtgc ctacaaaatc ctgctcagct gctggcgctt tgtttatatt
     5881 taaaaagaaa tggtgggtca ttttatccta ttttagccac gactccgcgt ttagcggcaa
     5941 agcgtttagc agacaaagca aactgccata tcgttatctt tgatattgag cagacgggac
     6001 tgacgctaaa aagagaagac aaagatcaac aagcggtttt agtacaaact agctctggaa
     6061 caacaggtga gccgaaagtg atcactcgct cttggttgtc tattgatgaa gaaattgaga
     6121 gttatgtgac aacttttact acacctcagt ccatgacccc tttaattgca tgtccaatta
     6181 ctcactctta tggattaatt tgtggcgtac ttgtcgcgct taagcgtgat ttagtgcctg
     6241 tgatcattac caacattaat cctaaatacc tattgagaaa atgcttagag aatagtgatc
     6301 acttacttta ttcatcgcca agtttactgc attctcttgt acaactatat ccaaaacaag
     6361 aacagctgca tgctgtaatg acgtcaggaa cggtgctacc gcaagcttgg tttgaagcga
     6421 taaaggtacg aagtcagtat ttattccagc aatacggctg ttctgaagca ggttgtattg
     6481 ccgtctgcga aaatcctgat tatgccaatc aaatgggctt tccacttcca catttaaggg
     6541 tatcagcagg gagtgatgta acttccccgc aagagatcat cgtatccaaa aataagcttg
     6601 atattaatac tcaagatctt ggtttttttg atgtgcaagg gcagttatgt ttcgtttccc
     6661 gtagcgatga catgattaat gtttctgggc tgaatgtgta tccacaagat gtggaaaacg
     6721 ttgtgatgga attagctgaa attacagatg cggtggtgtt taagcgtgcc gatgagttat
     6781 ctggtgagcg tgtatgtttg cagtttgtgg cagacactat gattgaacca agccgtattc
     6841 gtcaatggtg tggaacgcgt ttagcgaatc accagttacc cgttgatata gagcagcgcg
     6901 agattatcga aaaaggggca aacggaaaga taaaccgaaa agtgctttca caaagtagtg
     6961 tttcaattgc agcgattggt tagggaagaa aaatgcagcg cgaagaaatg atccaagcta
     7021 tcaaaaaagt gcttgaagaa aatatgcaaa atagccatat ggcgcttttt agtccatcag
     7081 caaagttgaa tgaagagttg tatttagatt cagtgttaat actccagctc attttacatt
     7141 tagagctcga tttaggattg accgtaccag agcaacatat tacagctgct gattatgcga
     7201 cagttgcgag cttagccgac tttctatgcc aggttaacaa tgagtcagag ctcgcaccga
     7261 aagagcctga ggttgaattt gaagatgtaa aagtacattg ctttgttagt tgtgtgtgtg
     7321 aagcgttaaa gagcaaaggc attgatcatc gaccatttta ttttgcggta tgggatgcga
     7381 cgtttgatgt aagtgagcgc taccaactgc aatatcatag tgatgatatt aatcaccaat
     7441 tatttattga ttggtaccaa cgtttgtttg gtggcgagct tatcgcttgg tatgacagtg
     7501 agaaaaccaa gcacgcgaat ttagccacca tgagagcgtt acttggtaat aaatcgaact
     7561 cagagcactt gatggtgatg ctcgatcttt atcatcttcc tgagcgtgaa aataaattta
     7621 atcagaaccc atttccccat tacgttatgt tgacggaaac agagacgcca gatcactgga
     7681 tgatgtggga tcctgacttt cgttggcaag gtgaaatttc acaagatcgt attgaaaatg
     7741 ctgtctctca gccaaccgtt gagggagggt atatttttaa tgaaaacgct ctgcaagatg
     7801 cgccgttaaa tgtggtgcaa gattatttca agctttgctt tattgaagat gaaaacccgc
     7861 tgacaaatgc cgttcgtgaa attattcaag ctcaccttga tgaaaaacag gggattagtt
     7921 tgtcagatct cccacttgct ttacgtgaat taaaagttat cgcggtacgt aaatatgcct
     7981 acgaacatgg ctttgcttat tttggcagag cgttaggtca aagtgatgat gactttgaat
     8041 attggtgtga tgtgattgaa gaattaatcc agacctatac cagtattcag tatcaagtaa
     8101 tgaaaatggc agaaaccaaa gatcttaatt tatatacagg tattcaatac ttgttggata
     8161 agcaagacag aacagaaaag cgtattaaaa aagggttatt tgatatgtat tccgattggt
     8221 gtgaattaaa cgacttaccg tgtgattcta ttatggaggt ttattgatat gcaattatct
     8281 atttgtacta tttcgtttcg ccatcaatta atgtcattag atcatttagc gcaatgggca
     8341 agaagccatg attttcaagg tatcgagctt tggggggtcc atgccataag tctggagtca
     8401 caacctcaat acgatgcgca atggttaaag gaaatgggac tctcgatttc aatgctaagt
     8461 gattacttac ccttagtggg tgatcccatc gtctctcaac aaaagtgtgc gcatatttgt
     8521 aagttagcga actattggaa tacaaataaa gtaaggactt ttgcggggca tcaagccagc
     8581 gataaggtta ataaaaatga ccgagaaaaa ctggttacta gactacgtca tatttgtgaa
     8641 tacgcgcatc aacaagggtt aaatgtactc gttgaaaccc atcccaatac tttagcggat
     8701 acgacagaat cgattcttca gcttttagat gaggtttatc atccggcttt aaaaattaat
     8761 tttgacagct tacatgtttg ggaatctggt gctgatatta attatttcca taatcaaatt
     8821 agtgattttg tcgatcatta ccacttaaaa aatatcgctt cacgagaata tttaaacgtg
     8881 ttttcacctg ataatgttta ttcgccagca ggtagccgag aaggaatgac acctttattt
     8941 gaaggggcat tagattatca acattttatt gatggattat ctcaaaataa aaatgcaaca
     9001 gcatcacttg agtggtttgg taataatgta aaacaaacct taataaatga taaaaaagca
     9061 ttagacaagt ttagcaagaa tataaaacag gctgagttgc tgttttagtt ttaatttata
     9121 tttaacttat ttcgataaat agtcattgat tataaaaaaa cgctcgtata ctatcagctg
     9181 tctaactgat agtgataacc attatcaata aaaataacag gtgtttggct agggattggc
     9241 atgaatatag ataaggtcca tcattcaaga acaatcttaa ttgtggaacc tgatcataat
     9301 tatggtcagc agttaattga actgttttgg cgtgaaggtt ttgtgatcaa acgttgtcaa
     9361 tctgcacttg aagctgaaaa cgtttataaa aatgcgatag tagatcttat gttggtctct
     9421 aatcaattac ctgaaatgaa gggttttacg tttttaaaac agtgtcgaca agtttctcac
     9481 attcctattg tcttattagc ggataactat agtgatacag aatgcgtaaa cagtttcttt
     9541 catggtgtag atgattacat tccacgtaaa cagccgatta aggaggtctt gtgtcgtgtt
     9601 attgcgattt taagacgtat tcagcagcgg caattaccgt caaataaaac caagttatta
     9661 attgttgatg atttgaaaat ggataagcaa agcttagcgg taagttataa agaaaccaca
     9721 ttatcaatga caccaattca atttaattta ctttggacat tagcttttca acagaatcaa
     9781 gtactgagta aagattattt ataccgacag gtattgtcac gtgagtttag tttatatgac
     9841 cgaagtttag atatgcactt aagccgagtt cggcgaaaat tagtatcggc aggtatgcct
     9901 gttgagcgac tgaaaacggc tcatggcgtt ggttacagtt ttaattaata taaaaaaagc
     9961 tcttatctaa aggtaagggc tttttccata tttattaagt ggttatgagg ttgtaacaat
    10021 tgtaaaaagt atttacatct tagtgcttag aagcaaaata atgataatta ttatcattaa
    10081 caagtggaaa ttaagatgtt gaaaggatgc aaattcaagc tgctaccgac tacggttgct
    10141 gtctcaagtg cgttgtttac acaaattgcg gttgccgact cagaaggtga acatgaaaaa
    10201 atggttgtaa tgggtaaccc attacaagcg actgaagtgt ttattgattc tgagcagctt
    10261 gaacgacaac aagccaacga tatcaatgat attttccgca cagatcccga agtcagcatt
    10321 ggtggtggta ctggtgttgc tcaaaagatt tatgttcgtg gtttagaaga tagccagcta
    10381 aacgtgacta ttgatggtgc cgttcaatca ggcaatattt tccaccacca agggcgttta
    10441 tcaatagaac cagagttatt gaaacaagtt gaagttgcgg ccggtgctgg acgtgctaca
    10501 gatggtgcgg gcgcactggg gggtgcgatt cgttttaaaa ccaaagatgc agaagacatg
    10561 ctacaaggtg gcgaacgttt tggtggctta gtgaaggcgg gctactatga taataccgaa
    10621 gggtataaaa cgagcgttag cggctatggc tatcttactg acaacgtaag cgttgttgct
    10681 actatggtgt atagcgattt aggcaactac acagat
//
