LOCUS       NZ_CP075564.1          10843 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP075564.1 Aeromonas media strain TR3_1 chromosome, complete
            genome.
ACCESSION   NZ_CP075564
VERSION     NZ_CP075564.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 15:26:17
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 1284208
            Orig. end    :: 1295051
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10843
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[1289208:1290051](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5843
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10843
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10843
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="3"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             951..2225
                     /locus_tag="ctg1_1160"
                     /transl_table=11
                     /translation="MNLYNIKDKSEQVSFAQAVRQGLGREQGLFFPEVIAPLADVDALL
                     DLPLAERSARIISHLLGDEVPKPKVSELINAAFTFPAPLVKLKDGTYALELFHGPTLAF
                     KDFGGRFMAQCLATFRTNDKITILTATSGDTGAAVAHAFYGLEGIEVVILYPKGKISPL
                     QEALFCTLGGNIRTIAIDGDFDACQALVKDAFDDEGLKTAIGLNSANSINISRLLAQVC
                     YYFEAVAQLPKGDRAKAVISVPSGNFGNLTAGLIAKALGLPVKRFIAATNANDTVPRYL
                     KTGSWEPHQTVATLSNAMDVSRPNNWPRVEELCRREGWALETLGSGMRSDAETRDALKR
                     LHQLDYLCEPHGAIAWDLLNEQLAEDEVGVFLCTAHPAKFKESVDEILGLDVPLPGPLA
                     KHAALPLLSHNLPADFGRLKAFLLG"
     PFAM_domain     969..1184
                     /aSDomain="Thr_synth_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF14821.8"
                     /description="Threonine synthase N terminus"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1160_0078"
                     /evalue="9.70E-07"
                     /label="ctg1_1160"
                     /locus_tag="ctg1_1160"
                     /protein_end="78"
                     /protein_start="6"
                     /score="29.0"
                     /tool="antismash"
                     /translation="KDKSEQVSFAQAVRQGLGREQGLFFPEVIAPLADVDALLDLPLAE
                     RSARIISHLLGDEVPKPKVSELINAAF"
     aSDomain        1158..2117
                     /aSDomain="TIGR00260"
                     /aSTool="tigrfam"
                     /description="thrC: threonine synthase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1160_0023"
                     /evalue="3.30E-109"
                     /identifier="TIGR00260"
                     /label="ctg1_1160"
                     /locus_tag="ctg1_1160"
                     /protein_end="389"
                     /protein_start="69"
                     /score="363.1"
                     /tool="antismash"
                     /translation="VSELINAAFTFPAPLVKLKDGTYALELFHGPTLAFKDFGGRFMAQ
                     CLATFRTNDKITILTATSGDTGAAVAHAFYGLEGIEVVILYPKGKISPLQEALFCTLGG
                     NIRTIAIDGDFDACQALVKDAFDDEGLKTAIGLNSANSINISRLLAQVCYYFEAVAQLP
                     KGDRAKAVISVPSGNFGNLTAGLIAKALGLPVKRFIAATNANDTVPRYLKTGSWEPHQT
                     VATLSNAMDVSRPNNWPRVEELCRREGWALETLGSGMRSDAETRDALKRLHQLDYLCEP
                     HGAIAWDLLNEQLAEDEVGVFLCTAHPAKFKESVDEILG"
     PFAM_domain     1224..2054
                     /aSDomain="PALP"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00291.27"
                     /description="Pyridoxal-phosphate dependent enzyme"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1160_0079"
                     /evalue="5.00E-22"
                     /label="ctg1_1160"
                     /locus_tag="ctg1_1160"
                     /protein_end="368"
                     /protein_start="91"
                     /score="78.8"
                     /tool="antismash"
                     /translation="YALELFHGPTLAFKDFGGRFMAQCLATFRTNDKITILTATSGDTG
                     AAVAHAFYGLEGIEVVILYPKGKISPLQEALFCTLGGNIRTIAIDGDFDACQALVKDAF
                     DDEGLKTAIGLNSANSINISRLLAQVCYYFEAVAQLPKGDRAKAVISVPSGNFGNLTAG
                     LIAKALGLPVKRFIAATNANDTVPRYLKTGSWEPHQTVATLSNAMDVSRPNNWPRVEEL
                     CRREGWALETLGSGMRSDAETRDALKRLHQLDYLCEPHGAIAWDLLNEQLAEDEV"
     CDS             2366..2767
                     /locus_tag="ctg1_1161"
                     /transl_table=11
                     /translation="MSQHPLRTLIETCDAAISRRDFDALMAFYAEDAALVVKPGMVARG
                     IPAIRRAFTAISDYFDGRLEVTQGAMEVIEGADNALVIMETRLRYPDAPGGLVDETRRA
                     TYVFRKESDGQWRCTIDNSYGTALLGMVE"
     aSDomain        2381..2728
                     /aSDomain="TIGR02246"
                     /aSTool="tigrfam"
                     /description="TIGR02246: conserved hypothetical protein"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1161_0024"
                     /evalue="2.40E-09"
                     /identifier="TIGR02246"
                     /label="ctg1_1161"
                     /locus_tag="ctg1_1161"
                     /protein_end="121"
                     /protein_start="5"
                     /score="35.2"
                     /tool="antismash"
                     /translation="LRTLIETCDAAISRRDFDALMAFYAEDAALVVKPGMVARGIPAIR
                     RAFTAISDYFDGRLEVTQGAMEVIEGADNALVIMETRLRYPDAPGGLVDETRRATYVFR
                     KESDGQWRCTID"
     PFAM_domain     2384..2719
                     /aSDomain="DUF4440"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF14534.8"
                     /description="Domain of unknown function (DUF4440)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1161_0080"
                     /evalue="6.10E-11"
                     /label="ctg1_1161"
                     /locus_tag="ctg1_1161"
                     /protein_end="118"
                     /protein_start="6"
                     /score="42.8"
                     /tool="antismash"
                     /translation="RTLIETCDAAISRRDFDALMAFYAEDAALVVKPGMVARGIPAIRR
                     AFTAISDYFDGRLEVTQGAMEVIEGADNALVIMETRLRYPDAPGGLVDETRRATYVFRK
                     ESDGQWRC"
     CDS             3940..4320
                     /locus_tag="ctg1_1162"
                     /transl_table=11
                     /translation="MKRILMVLSLCVTVMGMGMGVAQGATSGAQQECEAQAAVKKLAGA
                     AKTSFVGKCVKDASANGKAAQCEKAAADKKLAGAAKNSFIQKCVKTDAAADKATQCEKA
                     AADKKLAGAAKNSFVQKCVKTT"
     CDS             4676..4939
                     /locus_tag="ctg1_1163"
                     /transl_table=11
                     /translation="MNVKKSTAIASAMTGLLALGAQFIAAPVMAADDKEKCYGVVKAGK
                     NDCASKGGSCAGTAKMDAQGDAFVVVPKGLCEKLAGGSLQPK"
     PFAM_domain     4775..4927
                     /aSDomain="DUF2282"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF10048.11"
                     /description="Predicted integral membrane protein
                     (DUF2282)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1163_0081"
                     /evalue="1.40E-22"
                     /label="ctg1_1163"
                     /locus_tag="ctg1_1163"
                     /protein_end="84"
                     /protein_start="33"
                     /score="79.6"
                     /tool="antismash"
                     /translation="KEKCYGVVKAGKNDCASKGGSCAGTAKMDAQGDAFVVVPKGLCEK
                     LAGGSL"
     CDS             5001..5843
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_1164"
                     /sec_met_domain="DUF692 (E-value: 2e-83, bitscore: 277.6,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNPLIGIGLRPPHYDEIRQTLPAVGWLEVHSENYFERHSNGFEVL
                     AELAAHYPVSLHGVGMSLGSADSLDPAHLRQLAALVAAISPVRVSEHLSWGSIDGRYFN
                     DLLPMPYTREALSHMTDKVERVQQALGRQLLIENPSSYLQLPGEMGEAEFLAELARRSG
                     CGILLDLNNLHVSSVNHGLDCADYLAAIDLETVGEIHLAGFTDKVLPQGHLYIDTHSTP
                     VAPPVWELYRQVCQQRAIPTLIEWDQDIPPLPVLLGEAGRADAILGAARRISQEAAHV"
     PFAM_domain     5013..5801
                     /aSDomain="DUF692"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05114.15"
                     /description="Protein of unknown function (DUF692)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1164_0082"
                     /evalue="6.80E-100"
                     /label="ctg1_1164"
                     /locus_tag="ctg1_1164"
                     /protein_end="267"
                     /protein_start="4"
                     /score="333.7"
                     /tool="antismash"
                     /translation="IGIGLRPPHYDEIRQTLPAVGWLEVHSENYFERHSNGFEVLAELA
                     AHYPVSLHGVGMSLGSADSLDPAHLRQLAALVAAISPVRVSEHLSWGSIDGRYFNDLLP
                     MPYTREALSHMTDKVERVQQALGRQLLIENPSSYLQLPGEMGEAEFLAELARRSGCGIL
                     LDLNNLHVSSVNHGLDCADYLAAIDLETVGEIHLAGFTDKVLPQGHLYIDTHSTPVAPP
                     VWELYRQVCQQRAIPTLIEWDQDIPPLPVLLGEAGRADAIL"
     CDS             5836..6588
                     /locus_tag="ctg1_1165"
                     /transl_table=11
                     /translation="MSELARLQQGFASGLLGEDDTILAHLQPGRFPADAVLQIYRNNVI
                     LGLTEVLASSYPAVKAMVGEAFFAAAARGFVLAEPLREGSVMHYGEGFGDWLTRLPTTG
                     ALPWLGELARFEWMLERASLLAPEPRRWPAERLAALAPSQWDRLVLHPACDLLLLESQH
                     PVLALWQMALHGGETVSELDAPCWLALKKRPGHRVEPIPLDATPWRLLQGCQQGRPLAS
                     LLAQDPAMAEHLAPLITLDLLVDLELAP"
     PFAM_domain     5854..6126
                     /aSDomain="DUF2063"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09836.11"
                     /description="Putative DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1165_0083"
                     /evalue="1.10E-19"
                     /label="ctg1_1165"
                     /locus_tag="ctg1_1165"
                     /protein_end="97"
                     /protein_start="6"
                     /score="70.5"
                     /tool="antismash"
                     /translation="LQQGFASGLLGEDDTILAHLQPGRFPADAVLQIYRNNVILGLTEV
                     LASSYPAVKAMVGEAFFAAAARGFVLAEPLREGSVMHYGEGFGDWL"
     CDS             6585..7040
                     /locus_tag="ctg1_1166"
                     /transl_table=11
                     /translation="MTTQTHSKPLGLFAERILPWCSGALLLLARLWVAAVFLRSGWLKF
                     TAWDSTLYLFEFEYQVPLLPWQWAAYVGTATELLLPLFLLAGLFTRPVALLLFGFNAMA
                     IISYPALWAGGFHDHQLWGWMLLTLAVWGAGPLALDSWRLARGRRGH"
     PFAM_domain     6657..6905
                     /aSDomain="DoxX"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07681.14"
                     /description="DoxX"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1166_0084"
                     /evalue="9.60E-16"
                     /label="ctg1_1166"
                     /locus_tag="ctg1_1166"
                     /protein_end="107"
                     /protein_start="24"
                     /score="58.3"
                     /tool="antismash"
                     /translation="LLLLARLWVAAVFLRSGWLKFTAWDSTLYLFEFEYQVPLLPWQWA
                     AYVGTATELLLPLFLLAGLFTRPVALLLFGFNAMAIIS"
     CDS             7131..7592
                     /locus_tag="ctg1_1167"
                     /transl_table=11
                     /translation="MVREALAADVPALVRLRMALFCEVGELDDPLADAALWQATQAYFS
                     AAQADGSARSWLVEVEGEAVACGTLALFVRPPYPGNLAGREAYLLNMYTRPAWRKRGMA
                     SALLDAMARHAREQQLGKLWLHASDEGRPLYERIGFVANPACLEWCPAR"
     PFAM_domain     7275..7550
                     /aSDomain="Acetyltransf_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00583.27"
                     /description="Acetyltransferase (GNAT) family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1167_0085"
                     /evalue="4.30E-13"
                     /label="ctg1_1167"
                     /locus_tag="ctg1_1167"
                     /protein_end="140"
                     /protein_start="48"
                     /score="49.6"
                     /tool="antismash"
                     /translation="ADGSARSWLVEVEGEAVACGTLALFVRPPYPGNLAGREAYLLNMY
                     TRPAWRKRGMASALLDAMARHAREQQLGKLWLHASDEGRPLYERIGF"
     CDS             7785..9080
                     /locus_tag="ctg1_1168"
                     /transl_table=11
                     /translation="MFNHKLKAQLLACQTRLDEQQSVVEAIKDGAATIIFSPDGEILEV
                     SEPFLSLMGYGASELLGHHHRLLCPEGWTGSTDYQQFWRRLAQGEAQSGTFERVNRQGE
                     TRWLEASYFPVKTQGRVTRVVKMASDVTARHQRLQHLEALSQALDRSRAMIEFTPNGEI
                     ISANANFLDTMGYRLSELAGKHHRMFCDEAFLREQPTFWEELARGQFKSGLFMRHNSRG
                     EPVWLEATYNPIRDQRGKVVRVVKFASDITARIEQNNATREAARLAHSTAQETLGSAEA
                     GAELLRAVVDTSSLIAAQVDAAIALIGQLNEQSRSIEAIVSTISAIADQTNLLALNAAI
                     EAARAGEQGRGFAVVADEVRQLAARTSLSTGEIAKVVQKNRELTARVTDDMAGVAGSAE
                     LGKQQISEVDKLMSDIHREASRVSQTVSALSI"
     PFAM_domain     7875..8192
                     /aSDomain="PAS_4"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF08448.12"
                     /description="PAS fold"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1168_0086"
                     /evalue="2.40E-15"
                     /label="ctg1_1168"
                     /locus_tag="ctg1_1168"
                     /protein_end="136"
                     /protein_start="30"
                     /score="56.8"
                     /tool="antismash"
                     /translation="AATIIFSPDGEILEVSEPFLSLMGYGASELLGHHHRLLCPEGWTG
                     STDYQQFWRRLAQGEAQSGTFERVNRQGETRWLEASYFPVKTQGRVTRVVKMASDVTAR
                     HQ"
     aSDomain        7875..8198
                     /aSDomain="TIGR00229"
                     /aSTool="tigrfam"
                     /description="sensory_box: PAS domain S-box protein"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1168_0025"
                     /evalue="2.80E-16"
                     /identifier="TIGR00229"
                     /label="ctg1_1168"
                     /locus_tag="ctg1_1168"
                     /protein_end="138"
                     /protein_start="30"
                     /score="57.8"
                     /tool="antismash"
                     /translation="AATIIFSPDGEILEVSEPFLSLMGYGASELLGHHHRLLCPEGWTG
                     STDYQQFWRRLAQGEAQSGTFERVNRQGETRWLEASYFPVKTQGRVTRVVKMASDVTAR
                     HQRL"
     aSDomain        8205..8561
                     /aSDomain="TIGR00229"
                     /aSTool="tigrfam"
                     /description="sensory_box: PAS domain S-box protein"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1168_0026"
                     /evalue="1.60E-16"
                     /identifier="TIGR00229"
                     /label="ctg1_1168"
                     /locus_tag="ctg1_1168"
                     /protein_end="259"
                     /protein_start="140"
                     /score="58.5"
                     /tool="antismash"
                     /translation="LEALSQALDRSRAMIEFTPNGEIISANANFLDTMGYRLSELAGKH
                     HRMFCDEAFLREQPTFWEELARGQFKSGLFMRHNSRGEPVWLEATYNPIRDQRGKVVRV
                     VKFASDITARIEQNN"
     PFAM_domain     8247..8549
                     /aSDomain="PAS_4"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF08448.12"
                     /description="PAS fold"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1168_0087"
                     /evalue="1.20E-10"
                     /label="ctg1_1168"
                     /locus_tag="ctg1_1168"
                     /protein_end="255"
                     /protein_start="154"
                     /score="41.6"
                     /tool="antismash"
                     /translation="IEFTPNGEIISANANFLDTMGYRLSELAGKHHRMFCDEAFLREQP
                     TFWEELARGQFKSGLFMRHNSRGEPVWLEATYNPIRDQRGKVVRVVKFASDITARI"
     PFAM_domain     8676..9071
                     /aSDomain="MCPsignal"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00015.23"
                     /description="Methyl-accepting chemotaxis protein (MCP)
                     signalling domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1168_0088"
                     /evalue="3.70E-35"
                     /label="ctg1_1168"
                     /locus_tag="ctg1_1168"
                     /protein_end="429"
                     /protein_start="297"
                     /score="121.4"
                     /tool="antismash"
                     /translation="AQVDAAIALIGQLNEQSRSIEAIVSTISAIADQTNLLALNAAIEA
                     ARAGEQGRGFAVVADEVRQLAARTSLSTGEIAKVVQKNRELTARVTDDMAGVAGSAELG
                     KQQISEVDKLMSDIHREASRVSQTVSAL"
     CDS             9242..9799
                     /locus_tag="ctg1_1169"
                     /transl_table=11
                     /translation="MAVRQKGRALALLLGTVASMGLGGCMGQMGLSSMVTKGNLSVVDN
                     RYGRAGVFVLLSPVYGLAATADLFVFNTIEFWSGKNPITGKSPALVDHKADAVIKVNQH
                     LDPALNKVPLAMLPQGVREVKVSYPDERTAQMEIHYIDGHRDMMRGEMRGELLEIYLDD
                     KLVSTLTRQQLDETASSGKADV"
     PFAM_domain     9269..9772
                     /aSDomain="DUF3332"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF11810.10"
                     /description="Domain of unknown function (DUF3332)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1169_0089"
                     /evalue="1.70E-40"
                     /label="ctg1_1169"
                     /locus_tag="ctg1_1169"
                     /protein_end="177"
                     /protein_start="9"
                     /score="138.5"
                     /tool="antismash"
                     /translation="LALLLGTVASMGLGGCMGQMGLSSMVTKGNLSVVDNRYGRAGVFV
                     LLSPVYGLAATADLFVFNTIEFWSGKNPITGKSPALVDHKADAVIKVNQHLDPALNKVP
                     LAMLPQGVREVKVSYPDERTAQMEIHYIDGHRDMMRGEMRGELLEIYLDDKLVSTLTRQ
                     QLDET"
ORIGIN
        1 agcgtggtcg cctatgcacc ggcctccagc gccaacctga gcgtgggatt cgatgtactg
       61 ggggcggcgc tcgcccccgt ggatggctcc ctgctggggg atcgcgtcca ggtcaaatcg
      121 gcagaggtgc ctttcgccct ctcctccgtg ggccgctacg cccacaagct gccggatgat
      181 cccaagaaga acatccttta tgactgctgg gtcgcctatg gcgaggcgct ggagaagcgc
      241 ggcctgggcc tcaagccgct ggcgatggta ctggagaaga acctgccggt gggctcgggt
      301 ctgggttcca gcgcctgcag cgtggtggcg gcgctggaag ggctcaacgc cttccacggc
      361 gcgcccctca atgaacacga catgttgctg ctgatggggg agatggaagg caagatttcc
      421 ggctccgtcc actacgacaa cgtggccccc tgttatctcg gcggtatgca gctggtgctg
      481 gaagagcacg gcgtcatcag ccagggcata ccggtgttcg agcagtggta ctgggtggtc
      541 tgctacccgg gcacagtcgt ctccaccgcc gccgcccgcg ccatcctgcc cgcgcagtat
      601 cgccgtcagg attgcctcac ctacggtcgc cgcctggcgg ccttcgtgca cgccagctac
      661 acaggacaag aggggctggc ggccagcgta ttgaaggacg tgatcgccga gccctaccgt
      721 gcggcgctca ttgaaggctt caacgaggtg cgggcccagg gcgcccagaa cggggcactc
      781 gccaccggca tctcgggctc cggtcccacc gtgttcgtgg tgatgaagga tctggcccag
      841 gccgaacgga tgaaagagtg gatggaggcg cacttcgtgc gcaatgaaga tggatttgcc
      901 cgggtctgca aagtagacat cgaaggggca cgggtaacag gaagcgagct atgaatcttt
      961 acaatatcaa ggacaagagt gaacaggtca gctttgccca ggcggtgcgc cagggtctgg
     1021 gtcgcgagca ggggctcttc ttccccgagg tgattgcgcc cttggccgat gtggatgccc
     1081 tgctggactt gccgctggcc gagcgctccg cgcgcatcat cagccacctg ctgggggacg
     1141 aagtgcccaa gcctaaggtg agcgagctga tcaatgccgc cttcaccttc ccggcgccgc
     1201 tggtgaagct gaaagacggc acctatgccc tcgagctgtt ccacggcccg accctggcgt
     1261 tcaaggactt cggcggtcgc tttatggccc agtgcctcgc gaccttccgc accaacgaca
     1321 agatcactat cctcaccgcc acctcgggcg acaccggcgc cgccgtggcc cacgccttct
     1381 acgggctgga ggggattgag gtggtcatcc tctaccccaa gggcaagatc agccccttgc
     1441 aggaggcgct gttctgcacc ctcggcggca acatccgcac catcgccatc gacggcgact
     1501 tcgatgcctg tcaggcgctg gtcaaagatg ccttcgacga cgaggggctc aagaccgcca
     1561 tcggcctcaa ctccgccaac tccatcaaca tcagccgcct gctggcccag gtctgctact
     1621 acttcgaggc ggtggcccag ttgcccaagg gcgatcgtgc caaggcggtc atcagcgtgc
     1681 cgtccggcaa cttcggcaac ctcactgcgg gtctcatcgc caaggcgctg gggctgccgg
     1741 tgaagcgctt catcgccgcc accaatgcca acgacacagt gccgcgctac ttgaaaaccg
     1801 gcagctggga gccacaccag acggtggcaa cgctgtccaa tgccatggac gtgagccgcc
     1861 ccaacaactg gccgcgcgtg gaagagctgt gccgccgcga aggttgggcg ctggaaacct
     1921 tggggtctgg catgcgcagc gatgccgaga ctcgcgatgc ccttaaacgc ctgcaccagc
     1981 tcgattacct gtgcgagcct cacggcgcca tcgcctggga tctgctgaat gagcagctcg
     2041 ccgaggacga agtaggggtc ttcctctgca ccgctcatcc cgccaagttc aaggagtcgg
     2101 tggacgagat cctgggcctc gatgtgccgc tgccgggccc gctcgccaag cacgccgccc
     2161 tgccgctgct ctcccacaac ctgcccgccg actttggccg cctcaaggcc ttcctgctcg
     2221 gttaagccgc catgagacgc tgaagatccc ccgcttttat atcgagagcg ggggattttt
     2281 tatgtccggt atagggcggg gaaacccgca ttggattaag caccatttca cgatcagagc
     2341 gtgagcagat cctaaggagc actgtatgag ccaacatccc cttcgcacat tgatcgagac
     2401 ctgcgacgca gccatctccc ggcgcgactt cgacgccctg atggccttct atgcagagga
     2461 cgccgccctg gtggtcaaac ccggcatggt ggcgcgcggc attcccgcca tccgccgcgc
     2521 cttcaccgcc atctccgatt actttgacgg ccggcttgag gtgacccagg gagccatgga
     2581 ggtgatagag ggggccgaca acgccctggt gatcatggag acccggctgc gctacccgga
     2641 cgcgccaggc ggcctggtgg acgagacccg ccgcgccacc tatgtgtttc gcaaagagag
     2701 cgatggccag tggcgctgca ccatagacaa ctcctacggc actgcgctgc tgggtatggt
     2761 tgagtaaccg ccgaatcact gttctcgcca gtttctgact ggggtgctgg ccgattatcc
     2821 gggcacattg ctgcttgtct cccacgatcc cgagtttgtc gccggagtgg ggattgggcg
     2881 ggagtattgg ttggagggat agggataaaa catgagccag ccgagtaatg gctggctcag
     2941 aatggtggta cgccgatatt gcttctatga ctaggtagaa atgaaatgaa cttcaataac
     3001 tgatatggct tttcctggcc gaggatttct actatctggt tttattgcga tttgatcacc
     3061 ctcttttaat ttgctccact cgccccagct accattgact agggaaagtg cgaacaagta
     3121 tcccacgaac aaaaaatgaa aattttagtc atttaatatc aatgggttac cagtaaatgc
     3181 tctcgtgcca tatgacttat tcgcaccttc cctagatact acataattcc ctagagctat
     3241 ttcaagctca tgaagaacca ttgccgtttt tcttcggttg atttctggat tcatgtttcc
     3301 ctcaatggat tagttggtgg ctatctattt cagataaata atggtggtat ataaatgaaa
     3361 gattgtattt attggccgag gagtatcgta tattttacag ttttcgtagg ttgatatttc
     3421 tttctgtgaa gctaaatgtc tactgcgaag gtatttcggt ttatttaatg tttgtgtcat
     3481 caaatattaa atattctttt agaaagtatt tctcatttgc cgggtttcat ttaattcagt
     3541 gcaaaccaac gtcacaagcc tcaatatccc tgaggatgat gaacaaactc caagctaccg
     3601 cccctggatt acagcttcca atgcgctcca tggaccagcg ggcgggcccc ggatggtgct
     3661 gtaggcgccg aatgaccagc atatcctcaa gcctcatacg caaaccagtc agaaagtgac
     3721 gcaattatca ggaagatctg cgttttttgc gccagctcaa caattgcagg ggctgagcgg
     3781 ggaggaaggg gcgggatgtg ggatggcgta ttcggcgagc cggtgtgctt tttgttgtca
     3841 cggggcgggg ggactatagt gcagcgaggc gagggtgcct cgtttggccc gcgtgagtgg
     3901 gggctaacca caatggatag aacgatggga gttggtcata tgaagcggat cctgatggtg
     3961 ttgagtctgt gtgtgacggt aatgggcatg ggaatggggg tggcccaggg cgcaacctct
     4021 ggcgcgcagc aagagtgcga ggcccaggcg gcggtgaaga agctggcggg cgccgccaag
     4081 accagcttcg tgggcaagtg cgtcaaggat gcctcggcca acggcaaggc agcccagtgt
     4141 gaaaaagctg ccgccgacaa gaagctggcg ggggctgcca agaacagctt tatccagaag
     4201 tgcgtgaaga cggatgcagc cgccgacaag gcgactcagt gcgagaaggc ggcggcggac
     4261 aagaagctcg ccggggcggc caagaacagc ttcgtgcaaa agtgcgtcaa gaccacctga
     4321 acccttgggg gccaggagtg agcgagcgcc ttgggaagat cgtcgcccga gggaggagag
     4381 gggccatagg cccctctctt gtggtggtgc cagagccgga ttgacgtgac cccggtgcgc
     4441 ctcggcaagg gctgcgaacg acgcgttgat gagggacagc aggcggagct tcactccgcc
     4501 tcttttttga ttaaataaat atccatttaa aaacaatctc ttgctggctt tttatgggca
     4561 ttttttcagg ttttttcaat ttgtcggaaa tcttttctcc ccggcgccgg ttctattgga
     4621 cgtagccgga tgacatgcgc cggagacatc actctcgaca ataaggaata gggatatgaa
     4681 cgtgaaaaag agtactgcca tcgcctctgc catgacgggt ctgctggccc tgggtgccca
     4741 gttcatcgcc gcgccagtca tggcggcgga cgacaaggag aagtgctacg gcgtggtcaa
     4801 ggcgggcaag aacgattgcg ccagcaaggg cggctcctgc gccggtaccg ccaagatgga
     4861 tgcccagggg gatgccttcg tggtggtgcc caagggcctg tgcgagaagc tggcgggcgg
     4921 gtcgctgcaa cccaagtaag ccccatgcca tggtgtggca cccgccgcac catggcccct
     4981 tcctctgagg gagccctgcc atgaaccccc tgatcggtat aggtttacgt cccccccact
     5041 acgacgagat ccgccagacc ctgcctgcag tcggctggct cgaggtgcac agcgaaaact
     5101 acttcgagcg ccacagcaac ggcttcgagg tgctggccga actcgccgca cactaccccg
     5161 tcagcctgca cggggtcggc atgtcgctcg gctctgccga ctcgctcgat cccgcccacc
     5221 tgcgccagtt ggcggctctg gtggcggcca tctcaccggt gcgggtctcc gagcacctga
     5281 gttggggcag catcgacggg cgctatttca acgatctgct gcccatgccc tacacccgtg
     5341 aggccctctc gcacatgact gacaaggtgg agcgggtaca gcaggcgctg ggccggcaac
     5401 tgctcatcga gaatccgtcc tcctatctgc aactgcccgg ggagatgggg gaagctgagt
     5461 ttctggccga gctggcgcgg cgcagcggct gcggcatctt gctcgatctc aacaacctgc
     5521 atgtcagcag cgtcaatcac ggcttggatt gcgccgacta cctggccgcc atcgacctcg
     5581 agacggtcgg ggagatccat ctggccggtt ttaccgacaa ggtgttgcca caggggcacc
     5641 tctatatcga tacccacagc accccggtgg cgccccccgt gtgggagctc tatcggcagg
     5701 tctgccagca gcgcgccatc cccaccctga tcgagtggga tcaggacatt cccccgctgc
     5761 cggtgctgct gggggaggcc gggcgtgccg acgccatcct cggcgcggcg cggcggattt
     5821 cgcaggaggc cgcccatgtc tgagcttgcc cgcctgcaac aggggttcgc cagtggcctg
     5881 ctcggcgagg atgacaccat cctggcgcac ctccagccgg ggcgttttcc tgccgacgcc
     5941 gtgctgcaga tctatcgcaa caacgtcatc ctcggcctca ccgaggtgct cgccagcagt
     6001 tatcccgccg tcaaggccat ggtgggggag gcgttctttg ccgccgccgc ccggggattc
     6061 gtgctggccg agcccctgcg ggaggggagt gtcatgcact atggggaagg cttcggcgac
     6121 tggctcaccc gcctgccgac caccggggcc ctgccctggc tcggggagct ggcccgcttc
     6181 gagtggatgc tggagcgcgc ttccctgctg gcgccagagc cgaggcgctg gcccgccgag
     6241 cggctcgccg ccctcgcccc gagccagtgg gataggttgg tgctgcaccc cgcctgcgat
     6301 ctgctgctcc tcgagagcca gcatcctgtg ctggcgctct ggcagatggc actgcacggc
     6361 ggggagacgg tcagcgagct ggatgccccc tgctggctgg ccctcaagaa acgccccggc
     6421 cacagggtcg agcccattcc tctggatgca accccctggc gcctgctgca aggctgccag
     6481 cagggcaggc cgctggccag cctgctggca caggatccgg ccatggccga gcaccttgcc
     6541 cccctcatca ccctcgatct gctggtcgat ctggagcttg ccccatgaca acacagactc
     6601 actccaagcc gcttggcctc tttgccgaac gcatcctgcc ctggtgcagc ggcgccctgc
     6661 tgctgctggc cagactctgg gtcgccgccg tcttcctgcg atccggctgg ctcaagttca
     6721 cggcctggga ttccaccctc tacctgttcg agttcgagta tcaggtgccc ctgttgccct
     6781 ggcagtgggc ggcctacgtg ggcaccgcga ccgagctgct gctgccgctc ttcctgctgg
     6841 cgggcctctt cacccgcccg gtcgccttgc tgctgtttgg cttcaacgcc atggcgatca
     6901 tctcctaccc ggccctgtgg gcggggggct ttcacgatca ccagctgtgg ggctggatgt
     6961 tgctgaccct ggcggtgtgg ggcgcaggcc ccctggcgct ggacagctgg cgacttgcca
     7021 gggggcgtcg cggccattaa cgtgggtgcc aaatgagtga tggttggccc ctcttgtcat
     7081 ggtgacaggg ggcaaagagc cccgtcatgc cacccaagga gaaagagatg atggttcgcg
     7141 aggccctggc tgccgatgtt cccgccctgg tgcggctgcg catggcgctg ttttgcgagg
     7201 tgggggagct tgatgacccg ctggcggatg cggcgctgtg gcaggcgacc caggcctatt
     7261 tcagcgcggc gcaggcggat ggcagcgccc gttcttggct ggtggaggtc gagggcgagg
     7321 cggtggcgtg cggcacgctg gccctcttcg tgcgaccacc ctatccgggc aacctggcgg
     7381 ggcgcgaggc ctatctgctc aacatgtaca cccggcctgc ctggcgcaag cggggcatgg
     7441 cgagcgcctt gctcgatgcc atggcgcgcc atgcccggga acagcaactc ggcaagctgt
     7501 ggctgcacgc cagcgacgag ggacgcccgc tctacgagcg gatcggtttc gtggccaatc
     7561 cggcctgcct ggagtggtgc ccggcgcgct gatcgaggcg cagtgatccg gagaggattc
     7621 tgctacgtat tggcagccct tggcggccta gtcgcttttc tctgcactgc gcgcccccat
     7681 gatccaacgt catctgacca ctcatatcga ggttggtggg gccgatacag tcagtggggt
     7741 caggctgtgg tgccgatccg gatcgtcaac gaggtaggag tgtcatgttc aatcacaaac
     7801 tcaaggcgca gttgctggcc tgtcagaccc ggctcgatga gcagcagagt gtcgtcgagg
     7861 cgatcaagga cggcgccgcg accatcatct tcagcccgga cggggagatc ctggaggtca
     7921 gcgagccctt cctgagcctg atggggtatg gcgcgagcga gctgctaggg caccaccacc
     7981 gcctgctctg ccccgaaggc tggaccggct ccaccgacta tcagcagttc tggcgccgcc
     8041 tcgcccaggg ggaggcgcag tccggcacct tcgagcgggt caaccggcag ggggagaccc
     8101 gctggctcga ggcgagctat ttcccggtga agacccaggg cagggtgacc cgggtagtga
     8161 agatggccag cgatgtgacg gcccgacatc agcggctgca acacctggag gcgctgtccc
     8221 aggcgctgga ccgctcccgg gccatgatag agttcacccc gaacggcgag atcatcagcg
     8281 ccaacgccaa cttcctcgac accatgggct atcgcctgag cgagctggcg ggcaagcatc
     8341 acaggatgtt ctgtgacgag gccttcctgc gcgagcagcc cacattctgg gaggagctgg
     8401 cccgtggcca gttcaagtca ggccttttca tgcgccacaa cagccgggga gagcccgtct
     8461 ggctggaggc cacctacaac ccgatccggg accagcgcgg caaggtggtc agggtcgtca
     8521 agtttgccag cgacatcacg gcccgcatcg agcagaacaa tgctacccgg gaagcggccc
     8581 ggctcgccca cagcacggcg caggagaccc ttggcagcgc cgaggccggg gccgagctgc
     8641 tgcgcgccgt ggtcgatacc tcttccctca tcgccgccca ggtggatgcg gccatcgccc
     8701 tcatcggtca gctcaacgag cagtccagga gtatcgaggc catcgtctcg accatcagcg
     8761 ccatcgccga tcagaccaac ctgctggccc tcaacgcggc catcgaggcg gcgcgggcgg
     8821 gggagcaggg acggggcttt gcggtggtgg ccgacgaggt gcgtcaactg gcggctcgca
     8881 cttccctctc caccggcgag atagccaagg tggtgcagaa gaaccgcgag ctgaccgcca
     8941 gggtgaccga cgacatggcc ggggtggcgg gcagcgccga actcggcaag cagcaaatca
     9001 gcgaggtgga caagctgatg agcgacatcc accgggaggc gagccgggtt tcgcagacgg
     9061 tctcggcact ctccatctga gtcgtcgtcc ctgacgacac cgtctggcga gatcgccaaa
     9121 agagtgagcg aacgagcact caagctgaac cctggctgta cgaccccgcc cttgtgaatt
     9181 gtggcgcccc gccgccttgt ttaggctgcc gcctcttttt tcaatgagca ggtagagaac
     9241 aatggcagta cgacagaaag gcagggccct ggccctgctg ctggggacgg tggcgagcat
     9301 ggggctcggc ggttgcatgg ggcagatggg cctctcctcc atggtgacca agggcaacct
     9361 cagcgtggtg gacaatcgct acggtcgtgc cggtgtcttc gtcctgctct cccccgtcta
     9421 tggtctggcg gcgacggcgg atctgttcgt gttcaacacc atcgaattct ggtctggcaa
     9481 gaacccgatc accggcaagt ccccggcgct ggtggatcac aaggccgatg cggtgatcaa
     9541 ggtcaaccag catctggatc cggccctcaa caaggtgccg ctcgccatgc tgccgcaagg
     9601 ggtgcgcgag gtgaaggtga gctaccccga cgagcgcacg gcccagatgg agatccacta
     9661 catcgacggc catcgcgaca tgatgcgggg ggagatgcgc ggcgaactgc tggagatcta
     9721 tctggacgac aagctggtct cgaccctgac ccgccagcag ttggacgaaa cggcaagctc
     9781 aggcaaggct gacgtttaag ttcctcagga tcctgatctt ttcttctctg gaaagggtat
     9841 acataagctg ctggcaagat cgccatgacg tccaaggaag caggttatga cggtgagggg
     9901 tttgcgattg gcagagttga ttggttccct tagtcatgct ctggacatga cggagggtca
     9961 acccagaggg cactgcatcc gctgttgctg gataggttct cgtctggggg agcggctggg
    10021 actggatgcc cggcaacgcc acgatctcta ctacacgctc ctgctcaagg atctgggttg
    10081 cagcagcaat gccgcccgta tctgcgagct ctacctcacc gacgatcttc acttcaagcg
    10141 cgacttcaag ctggtggatg gctccctctc cgaggtggtc aacttcgtgt tgggtcacac
    10201 cggcttgcag acggacctgc tggggcgctt tcgcagcctg ttccatatct ttcgcaacgg
    10261 cgatcagata gccaacgaac ttatccagac ccgctgtcat cggggggcgg acatcgctcg
    10321 ccagctgcgc ttcagtgacg aggtggccgc aggcattctc tccctcgatg aacactggaa
    10381 cggcaagggg cggccactgc aactggctgg cgagaggatc cctctcttct cccgcattgc
    10441 cctgctctgc caggtggtcg atgtgtttca cgccgccgca gggccggatg ctgcgctcag
    10501 ggagctgcgc gagcgcagcg gcagctggtt tgatcccgcc ctggtcagcg aatttgaagc
    10561 gcttgccgac gacgatttct ggcaagggct gaccgacccc aggctgaccg agtgggtctt
    10621 cgaccacccg gccggtcagg gggaggtagc gctggatgag gattatctgg acgagatagc
    10681 ggcggccttc ggtcaggtgg tggactccaa gagtccatac accgcgggcc acagcggcag
    10741 ggtcgcgctc tataccgaca tcattgccgc tcagatgggg ctgtctgaat cgaggcggcg
    10801 atggctcaaa cggggtgccc tgctccatga cgtgggcaag ctt
//
