GCF_000215645.1_ASM21564v1_genomic - 6 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NC_017317.1

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NAPAA,betalactone	647,090	681,846
Region 2	siderophore	1,153,342	1,166,728
Region 3	LAP,thiopeptide	1,890,311	1,919,706
Region 4	NAPAA	2,095,322	2,129,152
Region 5	T1PKS	2,282,321	2,327,159
Region 6	terpene	2,457,222	2,478,355	carotenoid	Terpene	25%

NC_017317.1 - Region 1 - NAPAA,betalactone

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Location: 647,090 - 681,846 nt. (total: 34,757 nt) Show pHMM detection rules used

NAPAA: (AMP-binding and PP-binding and TIGR02353)
betalactone: (HMGL-like and AMP-binding)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000427.1	0.41	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0000375.1	0.39	NRP	indigoidine	Streptomyces chromofuscus
BGC0001138.1	0.37	Other (Nucleoside)	a201a	Marinactinospora thermotolerans
BGC0000878.1	0.37	Other	puromycin	Streptomyces alboniger
BGC0001844.1	0.36	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001641.1	0.36	NRP	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.1	0.35	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001135.1	0.35	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001128.1	0.35	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001900.1	0.35	NRP	fragin	Burkholderia cenocepacia H111

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000375.1	0.54	NRP	indigoidine	Streptomyces chromofuscus
BGC0000427.1	0.53	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0001399.1	0.53	NRP	fellutamide B	Aspergillus nidulans FGSC A4
BGC0001138.1	0.51	Other (Nucleoside)	a201a	Marinactinospora thermotolerans
BGC0000878.1	0.50	Other	puromycin	Streptomyces alboniger
BGC0001844.1	0.49	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001641.1	0.49	NRP	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.1	0.49	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001135.1	0.49	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001128.1	0.49	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1

Similar known gene clusters

No matches found.

Module view

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Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 647089 - 681846:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_621

Search NORINE for peptide: strict or relaxed

AMP-binding (29..407): X

NRPSPredictor2: hydrophobic-aliphatic

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAESIGtiiK
Nearest Stachelhaus code:: lys
Stachelhaus code match:: 70% (weak)

NC_017317.1 - Region 2 - siderophore

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Location: 1,153,342 - 1,166,728 nt. (total: 13,387 nt) Show pHMM detection rules used

siderophore: IucA_IucC

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001870.1	0.21	Other	putrebactin, avaroferrin	Xenorhabdus budapestensis
BGC0001498.1	0.21	Other	aerobactin	Xenorhabdus szentirmaii DSM 16338
BGC0001713.1	0.18	Other	ochrobactin	Ochrobactrum anthropi
BGC0000939.1	0.16	Other	aerobactin	Grimontia hollisae
BGC0000616.1	0.15	RiPP	amylocyclicin	Bacillus velezensis FZB42
BGC0000294.1	0.15	NRP	acinetobactin	Acinetobacter baumannii
BGC0000495.1	0.15	RiPP	actagardine	Actinoplanes garbadinensis
BGC0000947.1	0.15	Other	vibrioferrin	Vibrio alginolyticus
BGC0001120.1	0.14	NRP, Polyketide	burkholderic acid	Burkholderia thailandensis E264
BGC0000703.1	0.14	Saccharide	kanamycin	Streptomyces kanamyceticus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001870.1	0.54	Other	putrebactin, avaroferrin	Xenorhabdus budapestensis
BGC0001498.1	0.53	Other	aerobactin	Xenorhabdus szentirmaii DSM 16338
BGC0001713.1	0.49	Other	ochrobactin	Ochrobactrum anthropi
BGC0000939.1	0.47	Other	aerobactin	Grimontia hollisae
BGC0000616.1	0.46	RiPP	amylocyclicin	Bacillus velezensis FZB42
BGC0000294.1	0.46	NRP	acinetobactin	Acinetobacter baumannii
BGC0000495.1	0.45	RiPP	actagardine	Actinoplanes garbadinensis
BGC0000947.1	0.44	Other	vibrioferrin	Vibrio alginolyticus
BGC0001120.1	0.43	NRP, Polyketide	burkholderic acid	Burkholderia thailandensis E264
BGC0000703.1	0.43	Saccharide	kanamycin	Streptomyces kanamyceticus

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

Expand to show all names

NC_017317.1 - Region 3 - LAP,thiopeptide

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Location: 1,890,311 - 1,919,706 nt. (total: 29,396 nt) Show pHMM detection rules used

LAP: ((((goadsporin_like or PF00881 or TIGR03605) and (YcaO or TIGR03882 or TIGR03604)) or TIGR03603 or TIGR03602) and not cyanobactin_synth)
thiopeptide: ((YcaO or TIGR03882) and ((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or PF07366 or PF06968 or PF04055) or thiostrepton)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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MIBiG comparison

KnownClusterBlast

Thiopeptides

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000607.1	0.43	RiPP	micrococcin P1	Macrococcus caseolyticus
BGC0000569.1	0.40	RiPP	plantazolicin	Bacillus velezensis FZB42
BGC0001173.1	0.40	RiPP	plantazolicin	Bacillus pumilus ATCC 7061
BGC0000386.1	0.38	NRP	malleobactin A, malleobactin B, malleobactin C, malleobactin D	Burkholderia thailandensis E264
BGC0001171.1	0.38	RiPP	listeriolysin S	Listeria monocytogenes serotype 4b str. F2365
BGC0000566.1	0.36	RiPP	streptolysin S	Streptococcus pyogenes M1 GAS
BGC0001170.1	0.36	RiPP	clostridiolysin S	Clostridium sporogenes ATCC 15579
BGC0000565.1	0.36	RiPP	goadsporin	Streptomyces sp. TP-A0584
BGC0000564.1	0.36	RiPP	clostridiolysin S	Clostridium botulinum A str. ATCC 3502
BGC0000563.1	0.33	RiPP	venezuelin	Streptomyces venezuelae ATCC 10712

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000607.1	0.54	RiPP	micrococcin P1	Macrococcus caseolyticus
BGC0000569.1	0.53	RiPP	plantazolicin	Bacillus velezensis FZB42
BGC0001173.1	0.52	RiPP	plantazolicin	Bacillus pumilus ATCC 7061
BGC0000386.1	0.51	NRP	malleobactin A, malleobactin B, malleobactin C, malleobactin D	Burkholderia thailandensis E264
BGC0001171.1	0.51	RiPP	listeriolysin S	Listeria monocytogenes serotype 4b str. F2365
BGC0000566.1	0.50	RiPP	streptolysin S	Streptococcus pyogenes M1 GAS
BGC0001170.1	0.50	RiPP	clostridiolysin S	Clostridium sporogenes ATCC 15579
BGC0000565.1	0.50	RiPP	goadsporin	Streptomyces sp. TP-A0584
BGC0000564.1	0.50	RiPP	clostridiolysin S	Clostridium botulinum A str. ATCC 3502
BGC0000563.1	0.48	RiPP	venezuelin	Streptomyces venezuelae ATCC 10712

Similar known gene clusters

No matches found.

Thiopeptide predictions

No core peptides found.

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Thiopeptides

Core peptide predictions

No core peptides found.

NC_017317.1 - Region 4 - NAPAA

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Location: 2,095,322 - 2,129,152 nt. (total: 33,831 nt) Show pHMM detection rules used

NAPAA: (AMP-binding and PP-binding and TIGR02353)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000375.1	0.21	NRP	indigoidine	Streptomyces chromofuscus
BGC0000427.1	0.21	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0001399.1	0.20	NRP	fellutamide B	Aspergillus nidulans FGSC A4
BGC0001135.1	0.18	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001132.1	0.18	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001844.1	0.18	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001128.1	0.18	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.1	0.18	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001168.1	0.18	NRP	livipeptin	Streptomyces lividans 1326
BGC0001479.1	0.18	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000375.1	0.54	NRP	indigoidine	Streptomyces chromofuscus
BGC0000427.1	0.53	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0001399.1	0.53	NRP	fellutamide B	Aspergillus nidulans FGSC A4
BGC0001135.1	0.50	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001132.1	0.50	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001844.1	0.50	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001128.1	0.50	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.1	0.49	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001168.1	0.49	NRP	livipeptin	Streptomyces lividans 1326
BGC0001479.1	0.49	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102

Similar known gene clusters

No matches found.

Module view

Legend

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 4, location 2095321 - 2129152:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_1921

Search NORINE for peptide: strict or relaxed

AMP-binding (21..391): X

NRPSPredictor2: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAESIGtVvK
Nearest Stachelhaus code:: lys
Stachelhaus code match:: 80% (moderate)

NC_017317.1 - Region 5 - T1PKS

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Location: 2,282,321 - 2,327,159 nt. (total: 44,839 nt) Show pHMM detection rules used

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

Select a gene to view the details available for it

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001909.1	0.32	Polyketide	strobilurin	Strobilurus tenacellus
BGC0001831.1	0.24	Polyketide	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0001161.1	0.21	Polyketide	1-heptadecene	Moorea bouillonii PNG
BGC0001162.1	0.21	Polyketide	1-heptadecene	Moorea producens JHB
BGC0001163.1	0.21	Polyketide	1-heptadecene	Moorea producens 3L
BGC0000044.1	0.20	Polyketide	dawenol	Stigmatella aurantiaca DW4/3-1
BGC0001897.1	0.19	Polyketide	cepacin A	Burkholderia ambifaria IOP40-10
BGC0001281.1	0.19	Polyketide	ustilagic acid	Ustilago maydis 521
BGC0001264.1	0.19	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0001280.1	0.19	Polyketide	betaenone C, betaenone A	Phoma betae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001909.1	0.65	Polyketide	strobilurin	Strobilurus tenacellus
BGC0001831.1	0.58	Polyketide	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0001161.1	0.54	Polyketide	1-heptadecene	Moorea bouillonii PNG
BGC0001162.1	0.54	Polyketide	1-heptadecene	Moorea producens JHB
BGC0001163.1	0.54	Polyketide	1-heptadecene	Moorea producens 3L
BGC0000044.1	0.53	Polyketide	dawenol	Stigmatella aurantiaca DW4/3-1
BGC0001897.1	0.51	Polyketide	cepacin A	Burkholderia ambifaria IOP40-10
BGC0001281.1	0.51	Polyketide	ustilagic acid	Ustilago maydis 521
BGC0001264.1	0.51	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0001280.1	0.51	Polyketide	betaenone C, betaenone A	Phoma betae

Similar known gene clusters

No matches found.

Module view

Legend

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 5, location 2282320 - 2327159:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_2083

PKS_AT (643..933): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%

minowa: fatty_acid

Prediction, score:

fatty_acid: 109.2
Methylmalonyl-CoA: 71.4
Methoxymalonyl-CoA: 70.5
Malonyl-CoA: 69.8
Propionyl-CoA: 45.7
Ethylmalonyl-CoA: 45.0
2-Methylbutyryl-CoA: 36.5
Acetyl-CoA: 34.6
CHC-CoA: 32.0
trans-1,2-CPDA: 31.8
Isobutyryl-CoA: 29.8
inactive: 23.4
Benzoyl-CoA: 14.7
3-Methylbutyryl-CoA: 0.0

ctg1_2084

CAL_domain (200..537): pk

minowa: NH2

Prediction, score:

NH2: 52.1
Acetyl-CoA: 30.5
fatty_acid: 7.3
shikimic_acid: 0.0
AHBA: 0.0

NC_017317.1 - Region 6 - terpene

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Location: 2,457,222 - 2,478,355 nt. (total: 21,134 nt) Show pHMM detection rules used

terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000650.1	0.34	Terpene	carotenoid	Algoriphagus sp. KK10202C
BGC0000648.1	0.32	Terpene	carotenoid	Myxococcus xanthus
BGC0000637.1	0.20	Terpene	carotenoid	Corynebacterium glutamicum
BGC0000643.1	0.20	Terpene	carotenoid	Brevundimonas vesicularis
BGC0000634.1	0.20	Terpene	carotenoid	Brevundimonas sp. SD212
BGC0000644.1	0.19	Terpene	carotenoid	Dietzia sp. CQ4
BGC0000656.1	0.18	Terpene	zeaxanthin	Xanthobacter autotrophicus Py2
BGC0002031.1	0.17	Alkaloid	kitasetaline	Kitasatospora setae KM-6054
BGC0000636.1	0.15	Terpene	carotenoid	Brevibacterium linens
BGC0000810.1	0.15	Alkaloid	benzoxazinone DIMBOA	Zea mays

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000650.1	0.67	Terpene	carotenoid	Algoriphagus sp. KK10202C
BGC0000648.1	0.66	Terpene	carotenoid	Myxococcus xanthus
BGC0000637.1	0.52	Terpene	carotenoid	Corynebacterium glutamicum
BGC0000643.1	0.52	Terpene	carotenoid	Brevundimonas vesicularis
BGC0000634.1	0.52	Terpene	carotenoid	Brevundimonas sp. SD212
BGC0000644.1	0.51	Terpene	carotenoid	Dietzia sp. CQ4
BGC0000656.1	0.49	Terpene	zeaxanthin	Xanthobacter autotrophicus Py2
BGC0002031.1	0.48	Alkaloid	kitasetaline	Kitasatospora setae KM-6054
BGC0000636.1	0.46	Terpene	carotenoid	Brevibacterium linens
BGC0000810.1	0.44	Alkaloid	benzoxazinone DIMBOA	Zea mays

Similar known gene clusters

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names