LOCUS       NZ_AP022254.1          10843 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_AP022254.1 Aeromonas caviae strain WP8-S18-ESBL-04 chromosome,
            complete genome.
ACCESSION   NZ_AP022254
VERSION     NZ_AP022254.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 13:09:47
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 3155607
            Orig. end    :: 3166450
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10843
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[3160607:3161450](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5843)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10843
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10843
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="3"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(1018..1575)
                     /locus_tag="ctg1_2799"
                     /transl_table=11
                     /translation="MAVRQRGRALALLLGMGASLGLGGCMGQMGLSSMVTKGNLSVVDN
                     RYGRAGVFVLLSPVYGLAATADLFVFNTIEFWSGKNPITGKAPALVDQKSDAIIKVNQH
                     LDPALNQVPLALLPQGVREVQVSYPDERTAQMEIHYIDGQRSLMRGEMRGERLDLYLDD
                     KLVSTLSREQLDAAASRGAVQA"
     PFAM_domain     complement(1045..1548)
                     /aSDomain="DUF3332"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF11810.10"
                     /description="Domain of unknown function (DUF3332)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2799_0081"
                     /evalue="7.90E-41"
                     /label="ctg1_2799"
                     /locus_tag="ctg1_2799"
                     /protein_end="177"
                     /protein_start="9"
                     /score="139.6"
                     /tool="antismash"
                     /translation="LALLLGMGASLGLGGCMGQMGLSSMVTKGNLSVVDNRYGRAGVFV
                     LLSPVYGLAATADLFVFNTIEFWSGKNPITGKAPALVDQKSDAIIKVNQHLDPALNQVP
                     LALLPQGVREVQVSYPDERTAQMEIHYIDGQRSLMRGEMRGERLDLYLDDKLVSTLSRE
                     QLDAA"
     CDS             complement(1720..3015)
                     /locus_tag="ctg1_2800"
                     /transl_table=11
                     /translation="MFNQKLKAQLQACQTRLDEEQGIIEAIKAGAATVIFSPEGIIQEA
                     STPFLALMGYGAAELIGQPHSQLCPRAWGESGDYRQFWRRLAQGEVQSGTFERVNRQGE
                     TRWLEATYFPVKHQGRVTRVLKIASDVTEQHQRLGRLEGLTEALDRSRAMIEFTPSGDI
                     LHANANFLSVMGYTLSEIAGRHHRIFCDEAFLREQPRFWEELARGQFKSGLFMRHNSRG
                     QAVWLEATYNPIRDGSGKVVRVVKFASDITARIEQNHATREAARLAHSTAQETLHSAEE
                     GAGLLRAVVQTSSLIASQVDEAIALIGQLNEQSRSIEAIVSTISAIADQTNLLALNAAI
                     EAARAGEQGRGFAVVADEVRQLAARTSLSTDEIARVVQKNRELTARVTDDMAGVAGSAE
                     LGKQQIAGVDKLMSEIHQEADRVSQTVSALSI"
     PFAM_domain     complement(1729..2127)
                     /aSDomain="MCPsignal"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00015.23"
                     /description="Methyl-accepting chemotaxis protein (MCP)
                     signalling domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2800_0084"
                     /evalue="6.30E-35"
                     /label="ctg1_2800"
                     /locus_tag="ctg1_2800"
                     /protein_end="429"
                     /protein_start="296"
                     /score="120.6"
                     /tool="antismash"
                     /translation="ASQVDEAIALIGQLNEQSRSIEAIVSTISAIADQTNLLALNAAIE
                     AARAGEQGRGFAVVADEVRQLAARTSLSTDEIARVVQKNRELTARVTDDMAGVAGSAEL
                     GKQQIAGVDKLMSEIHQEADRVSQTVSAL"
     aSDomain        complement(2242..2586)
                     /aSDomain="TIGR00229"
                     /aSTool="tigrfam"
                     /description="sensory_box: PAS domain S-box protein"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_2800_0027"
                     /evalue="1.70E-15"
                     /identifier="TIGR00229"
                     /label="ctg1_2800"
                     /locus_tag="ctg1_2800"
                     /protein_end="258"
                     /protein_start="143"
                     /score="55.3"
                     /tool="antismash"
                     /translation="LTEALDRSRAMIEFTPSGDILHANANFLSVMGYTLSEIAGRHHRI
                     FCDEAFLREQPRFWEELARGQFKSGLFMRHNSRGQAVWLEATYNPIRDGSGKVVRVVKF
                     ASDITARIEQN"
     PFAM_domain     complement(2251..2553)
                     /aSDomain="PAS_4"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF08448.12"
                     /description="PAS fold"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2800_0083"
                     /evalue="1.70E-09"
                     /label="ctg1_2800"
                     /locus_tag="ctg1_2800"
                     /protein_end="255"
                     /protein_start="154"
                     /score="38.0"
                     /tool="antismash"
                     /translation="IEFTPSGDILHANANFLSVMGYTLSEIAGRHHRIFCDEAFLREQP
                     RFWEELARGQFKSGLFMRHNSRGQAVWLEATYNPIRDGSGKVVRVVKFASDITARI"
     PFAM_domain     complement(2608..2925)
                     /aSDomain="PAS_4"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF08448.12"
                     /description="PAS fold"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2800_0082"
                     /evalue="1.40E-14"
                     /label="ctg1_2800"
                     /locus_tag="ctg1_2800"
                     /protein_end="136"
                     /protein_start="30"
                     /score="54.4"
                     /tool="antismash"
                     /translation="AATVIFSPEGIIQEASTPFLALMGYGAAELIGQPHSQLCPRAWGE
                     SGDYRQFWRRLAQGEVQSGTFERVNRQGETRWLEATYFPVKHQGRVTRVLKIASDVTEQ
                     HQ"
     aSDomain        complement(2608..2928)
                     /aSDomain="TIGR00229"
                     /aSTool="tigrfam"
                     /description="sensory_box: PAS domain S-box protein"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_2800_0026"
                     /evalue="2.60E-15"
                     /identifier="TIGR00229"
                     /label="ctg1_2800"
                     /locus_tag="ctg1_2800"
                     /protein_end="136"
                     /protein_start="29"
                     /score="54.6"
                     /tool="antismash"
                     /translation="GAATVIFSPEGIIQEASTPFLALMGYGAAELIGQPHSQLCPRAWG
                     ESGDYRQFWRRLAQGEVQSGTFERVNRQGETRWLEATYFPVKHQGRVTRVLKIASDVTE
                     QHQ"
     CDS             complement(3218..3682)
                     /locus_tag="ctg1_2801"
                     /transl_table=11
                     /translation="MKVREALAADIPALTTLRMALFCEVGELARPDEDPVLREATQAYF
                     IQAQEEGSARSWVVEEEGEVVACATLALFVRPPYPGNMAGREGYLLNIYTRPAWRRRGM
                     ANALLVAMVAYAREQQLGKLWLHASSDGRAIYERFGFAANPACLECVPAR"
     PFAM_domain     complement(3260..3574)
                     /aSDomain="Acetyltransf_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00583.27"
                     /description="Acetyltransferase (GNAT) family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2801_0085"
                     /evalue="9.40E-14"
                     /label="ctg1_2801"
                     /locus_tag="ctg1_2801"
                     /protein_end="141"
                     /protein_start="36"
                     /score="51.7"
                     /tool="antismash"
                     /translation="LREATQAYFIQAQEEGSARSWVVEEEGEVVACATLALFVRPPYPG
                     NMAGREGYLLNIYTRPAWRRRGMANALLVAMVAYAREQQLGKLWLHASSDGRAIYERFG
                     F"
     CDS             complement(3743..4198)
                     /locus_tag="ctg1_2802"
                     /transl_table=11
                     /translation="MTTQTLARPLGPLVERILPWCSGGLLLLARLWVATIFLRSGWLKF
                     TAWDSTLYLFEFEYQVPLLPWQWAAYAGTATELLLPLFLLAGLFTRPVALLLFGFNAMA
                     VISYPALWAGGFHDHQLWGWMLLTLAVWGAGPLGLDSWRLARRSPPA"
     PFAM_domain     complement(3881..4126)
                     /aSDomain="DoxX"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07681.14"
                     /description="DoxX"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2802_0086"
                     /evalue="2.30E-15"
                     /label="ctg1_2802"
                     /locus_tag="ctg1_2802"
                     /protein_end="106"
                     /protein_start="24"
                     /score="57.1"
                     /tool="antismash"
                     /translation="LLLLARLWVATIFLRSGWLKFTAWDSTLYLFEFEYQVPLLPWQWA
                     AYAGTATELLLPLFLLAGLFTRPVALLLFGFNAMAVI"
     CDS             complement(4195..4947)
                     /locus_tag="ctg1_2803"
                     /transl_table=11
                     /translation="MSELASLQRAFASGLLGQDDAILGHIQPGRFAPDALLQIYRNNFI
                     LGLTEVLASSYPAVRAMVGETFFEAAARGFVLAAPLEEGSVMDYGEGFGDWLARLPTTA
                     ALPWLGDLARFEWGLERVSLLAPETRRWPAERLAAMTPEHWERLVLHPACDLQLLESPH
                     PVLALWQMALHGGETVRELDAVCSLALKKRPGHRVDPIPLDAAAWRLLQGCLQGRPLAS
                     LLAQDPAMAEHLAPLITLDLLVDLELAP"
     PFAM_domain     complement(4657..4929)
                     /aSDomain="DUF2063"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09836.11"
                     /description="Putative DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2803_0087"
                     /evalue="5.40E-20"
                     /label="ctg1_2803"
                     /locus_tag="ctg1_2803"
                     /protein_end="97"
                     /protein_start="6"
                     /score="71.5"
                     /tool="antismash"
                     /translation="LQRAFASGLLGQDDAILGHIQPGRFAPDALLQIYRNNFILGLTEV
                     LASSYPAVRAMVGETFFEAAARGFVLAAPLEEGSVMDYGEGFGDWL"
     CDS             complement(5001..5843)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_2804"
                     /sec_met_domain="DUF692 (E-value: 1.4e-78, bitscore: 261.7,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNPLIGIGLRPPHYDEIRHTLPGMGWLEVHSENYFERHNQGFEVL
                     AELARHYPVSLHGVGMSLGSADPLDAGHLRQLAALVAAISPVRVSEHLSWGSIGGRYFN
                     DLLPMPYTRATLLYMSDKIDRVQQTLGRQLLIENPSSYLQLAGEMGEAEFLAELVERSG
                     CGVLLDLNNLHVSAVNHGLEVDDYLATIDLDTVGEIHLAGFTEKHLPQGPLYIDTHSTP
                     VAEPVWVLYEQVCQQRAIPTLIEWDLAIPPLPVLLGEAQRASEILSAAQQTSREAALV"
     PFAM_domain     complement(5043..5831)
                     /aSDomain="DUF692"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05114.15"
                     /description="Protein of unknown function (DUF692)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2804_0088"
                     /evalue="6.20E-97"
                     /label="ctg1_2804"
                     /locus_tag="ctg1_2804"
                     /protein_end="267"
                     /protein_start="4"
                     /score="324.0"
                     /tool="antismash"
                     /translation="IGIGLRPPHYDEIRHTLPGMGWLEVHSENYFERHNQGFEVLAELA
                     RHYPVSLHGVGMSLGSADPLDAGHLRQLAALVAAISPVRVSEHLSWGSIGGRYFNDLLP
                     MPYTRATLLYMSDKIDRVQQTLGRQLLIENPSSYLQLAGEMGEAEFLAELVERSGCGVL
                     LDLNNLHVSAVNHGLEVDDYLATIDLDTVGEIHLAGFTEKHLPQGPLYIDTHSTPVAEP
                     VWVLYEQVCQQRAIPTLIEWDLAIPPLPVLLGEAQRASEIL"
     CDS             complement(5903..6166)
                     /locus_tag="ctg1_2805"
                     /transl_table=11
                     /translation="MNVKKSTAIASAMTGLLALGAQFIAAPAMAADDKEKCYGVVKAGK
                     NDCATKGGSCAGTAKMDAQGDAFVVVPKGLCEKLAGGSLQPK"
     PFAM_domain     complement(5915..6067)
                     /aSDomain="DUF2282"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF10048.11"
                     /description="Predicted integral membrane protein
                     (DUF2282)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2805_0089"
                     /evalue="1.30E-22"
                     /label="ctg1_2805"
                     /locus_tag="ctg1_2805"
                     /protein_end="84"
                     /protein_start="33"
                     /score="79.7"
                     /tool="antismash"
                     /translation="KEKCYGVVKAGKNDCATKGGSCAGTAKMDAQGDAFVVVPKGLCEK
                     LAGGSL"
     CDS             complement(6569..6682)
                     /locus_tag="ctg1_2806"
                     /transl_table=11
                     /translation="MKGIAILMTVLVMGMGADKKLAGAAKNSFIQKCVKTA"
     CDS             6971..8995
                     /locus_tag="ctg1_2807"
                     /transl_table=11
                     /translation="MNAPHPPRCTLSLPIFIPGLLFILTLLAICSLAPEAAARFFGSGQ
                     SWIAQHFSWFYVLVVGMFLILLLVIAFSHFGNIRLGPDDARPEFSFTSWLAMLFAAGMG
                     IGLMYFGVGEPMSHYVSPPQATPLTPVAAREAMVTTFFHWGFHAWAVYAIVGLVLAYFG
                     FRYNLPLTIRSGLYPIFKEKIHGPLGHAVDVFALVGTIFGIATTLGYGVMQLSAGITRL
                     TGMDTSGDLFRFGLIGAVIALAGVSAVTGLDKGVKRLSELNLFLAIVLLLFVLVAGPTK
                     YLLGALSENIGNYVSSLSQLTFRTFTYSETRQAGWFGNWTLLYWAWWISWSPFVGLFIA
                     RISRGRTLREFILGVLFVPTAFNLLWMTVFGNAAIWASQHEGGTSLIDSVGNIDTLLFN
                     FFDLLPGADITSALAVILISVFFVTSADSGAFVIDNIATQGKEGSPVWQRLFWALLLGV
                     TAGTLMSTGGLAALQSMTLIAALPFAFIMVLLCLGLCRGLVADKEHSARRLSPATDFWN
                     GKQWRTRMDHLLRPSTEQEARAFVDKVALPALTALSQEFAARGITSRVEEDGPDQCHLL
                     VPQQGRRDFCYGVRIEARPAPAFNPLEAAHNHDPEARIFEPITYFADGRAGYDIQYLTR
                     DELSADVLRQYERYLVLSQDEGQDLLSSAPEHTQPTQGE"
     PFAM_domain     7013..8464
                     /aSDomain="BCCT"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02028.19"
                     /description="BCCT, betaine/carnitine/choline family
                     transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2807_0090"
                     /evalue="1.90E-181"
                     /label="ctg1_2807"
                     /locus_tag="ctg1_2807"
                     /protein_end="498"
                     /protein_start="14"
                     /score="603.9"
                     /tool="antismash"
                     /translation="IFIPGLLFILTLLAICSLAPEAAARFFGSGQSWIAQHFSWFYVLV
                     VGMFLILLLVIAFSHFGNIRLGPDDARPEFSFTSWLAMLFAAGMGIGLMYFGVGEPMSH
                     YVSPPQATPLTPVAAREAMVTTFFHWGFHAWAVYAIVGLVLAYFGFRYNLPLTIRSGLY
                     PIFKEKIHGPLGHAVDVFALVGTIFGIATTLGYGVMQLSAGITRLTGMDTSGDLFRFGL
                     IGAVIALAGVSAVTGLDKGVKRLSELNLFLAIVLLLFVLVAGPTKYLLGALSENIGNYV
                     SSLSQLTFRTFTYSETRQAGWFGNWTLLYWAWWISWSPFVGLFIARISRGRTLREFILG
                     VLFVPTAFNLLWMTVFGNAAIWASQHEGGTSLIDSVGNIDTLLFNFFDLLPGADITSAL
                     AVILISVFFVTSADSGAFVIDNIATQGKEGSPVWQRLFWALLLGVTAGTLMSTGGLAAL
                     QSMTLIAALPFAFIMVLLCLGLCRGL"
     aSDomain        7127..8473
                     /aSDomain="TIGR00842"
                     /aSTool="tigrfam"
                     /description="bcct: transporter, betaine/carnitine/choline
                     transporter (BCCT) family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_2807_0028"
                     /evalue="1.40E-160"
                     /identifier="TIGR00842"
                     /label="ctg1_2807"
                     /locus_tag="ctg1_2807"
                     /protein_end="501"
                     /protein_start="52"
                     /score="532.9"
                     /tool="antismash"
                     /translation="SWFYVLVVGMFLILLLVIAFSHFGNIRLGPDDARPEFSFTSWLAM
                     LFAAGMGIGLMYFGVGEPMSHYVSPPQATPLTPVAAREAMVTTFFHWGFHAWAVYAIVG
                     LVLAYFGFRYNLPLTIRSGLYPIFKEKIHGPLGHAVDVFALVGTIFGIATTLGYGVMQL
                     SAGITRLTGMDTSGDLFRFGLIGAVIALAGVSAVTGLDKGVKRLSELNLFLAIVLLLFV
                     LVAGPTKYLLGALSENIGNYVSSLSQLTFRTFTYSETRQAGWFGNWTLLYWAWWISWSP
                     FVGLFIARISRGRTLREFILGVLFVPTAFNLLWMTVFGNAAIWASQHEGGTSLIDSVGN
                     IDTLLFNFFDLLPGADITSALAVILISVFFVTSADSGAFVIDNIATQGKEGSPVWQRLF
                     WALLLGVTAGTLMSTGGLAALQSMTLIAALPFAFIMVLLCLGLCRGLVAD"
     CDS             complement(9155..9535)
                     /locus_tag="ctg1_2808"
                     /transl_table=11
                     /translation="MKRILMVLSLCVTVMGMGMGVAQSATSGAQQECEAQAAVKKLAGA
                     AKTSFVGKCVKDASASAKASQCEKAAADKKLAGAAKNSFVQKCLKTDGAADKATQCEKA
                     AADKKLAGAAKNSFIQKCVKTA"
ORIGIN
        1 ggcaccccgc ttgagccagc gtcgccgtgg ctcggacagc cccatctggg cggcgaggat
       61 gtcggtatag agcgccaccc tgccgctgtg ccccgcggta taggggctct tggagtccac
      121 cacctggccg aaggccgcag caatctcatc cagataatcc tcatccagcg ccacctcccc
      181 ctgccccgcc gggtgggcga agacccgctc cgccaacgcg ggatccgcca gcccttgcca
      241 gaaggcctcg tctgccagcg cctcgaaggc gctgaccagg gcgggatcaa accagttgcc
      301 gctgcgctcg cgcagctccc tcatcgccgc gtccggcccg gcggcggcgt gaaacacgtc
      361 caccacctga cagagcaggg cgatgcggga gaagagcggg atggcctctc ccgccagttg
      421 ttgcggtcgc cctttgccgc tccagtgctc atccagggag aggatcccct gggccacctc
      481 gtcgctgaaa cgcaactggc gggcgatgtc cgccccccgg tggcagcggg tcaggatcag
      541 ctcgttggct atctgatccc cgttgcgaaa gatgtgaaac aggctgcgaa aacggcccag
      601 cagatccgcc tgcaagccgg tgtggcccag tacgaagttg accacctcgg agagggagcc
      661 atccaccagc ttgaagtcgc gcttgaagtg aagatcgtcg gtgagataga gctcgcagat
      721 gcgggcggca ttgctgctgc accccagatc cttgagcaac agggtgtaat agaggtcgtg
      781 gcgctgccgg gcatccagtc ccagttgctc ccccagacga gagcctatcc agcagcagcg
      841 gatgcaatgg cctctcggct gcccttccgt catgtccagg gcatggctga gagaaccaat
      901 cagctctgcc aaacgcaacc cgtttaccgt catagcccac tccctctaca tcggggcgta
      961 cttgcccgca ggcatgtata gcatttgtcg ggagtaaagg atcaggggcg cgacaaatta
     1021 tgcctgcacc gctccccgac ttgccgccgc atcgagctgc tcgcggctca gggtcgagac
     1081 cagtttgtca tccagataga gatccagccg ctccccgcgc atctctcccc gcatcaggct
     1141 gcgctgaccg tcgatgtagt ggatctccat ctgggcggtg cgctcgtccg ggtagctcac
     1201 ctgtacctcg cgcacccctt ggggcagcag ggccagcggt acctggttga gggcaggatc
     1261 caggtgctgg ttcaccttga tgatcgcatc gctcttctga tccaccaggg cgggcgcctt
     1321 gccggtgatg gggttcttgc cggaccagaa ttcgatggtg ttgaacacga agagatccgc
     1381 cgtggccgcc aggccataga cgggggaaag gagcacgaag acgccggcac ggccgtagcg
     1441 gttgtccacc acgctgaggt tgcccttggt caccatggaa gagaggccca tctggcccat
     1501 gcaaccaccg agccccaggc tcgcccccat tcccagcagc agggccagtg ccctgcctct
     1561 ctgtcgtact gccattgttg tctacctgct caataaaaag gaggcggcag cctaaacaag
     1621 ggggccgggc ggcacaatga tgaagggggg cgtcatacag ccagggttca gcctggccgt
     1681 ccgatcgctc actctgttgg caatcttgcg gtcagcccct cagatggaga gggccgacac
     1741 cgtctgggag accctgtccg cctcctggtg gatctcgctc atcagcttgt ccacgccggc
     1801 gatctgctgc ttgccgagtt cggcgctgcc cgccaccccg gccatgtcgt cggtcaccct
     1861 ggcggtcagc tcgcggttct tctgcaccac cctggcgatc tcgtcggtag agagcgacgt
     1921 gcgggcggcc agctggcgca cctcgtccgc caccaccgca aacccgcgcc cctgctcccc
     1981 tgcccgcgcc gcctcgatgg cggcgttcag ggccagcaga ttggtctgat cggcgatggc
     2041 gctgatggtc gaaacgatgg cctcgatgct tctggactgc tcgttgagct ggccgatgag
     2101 ggcgatggcc tcatccacct gggaggcgat gagggaagag gtctgcacca cggcgcgcag
     2161 caagcccgcc ccctcctctg cgctgtgcag ggtctcctgg gcggtgctgt gggccaggcg
     2221 ggccgcctcc cgggtggcgt ggttctgctc gatgcgcgcg gtgatgtcgc tggcgaactt
     2281 caccacccgt accaccttgc cgctgccatc ccggatgggg ttgtaggtcg cctccagcca
     2341 gacggcctgc ccccggctgt tgtggcgcat gaagaggccg gatttgaact ggccccgggc
     2401 cagctcctcc cagaaacggg gctgctcgcg cagaaaggcc tcgtcacaga agatcctgtg
     2461 gtgcctgccc gcgatctcac tcagggtgta acccatgacg ctcaggaagt tggcattggc
     2521 atggaggatg tcgccgctcg gggtgaactc gatcatggcc cgggagcggt ccagcgcctc
     2581 ggtcagcccc tcgagccgcc caagccgctg gtgctgttcg gtgacgtcgc tggcaatctt
     2641 gagtacccgg gtcacccggc cctggtgctt caccgggaaa taggtcgcct ccagccagcg
     2701 cgtctccccc tgccggttca cgcgctcgaa ggtgcctgac tgcacctccc cctgagcgag
     2761 acgccgccag aactggcgat agtcaccgga ctccccccag gccctcggac agagctggct
     2821 gtggggctgc ccaatcagtt cggcggcccc atatcccatc agggccagga aaggggtgct
     2881 cgcctcctgg atgatcccct ccgggctgaa gatgacggtg gcggcacccg ccttgatcgc
     2941 ctctatgatg ccctgctcct cgtcgagccg ggtctggcat gcctgcaact gcgctttgag
     3001 cttctgattg aacatgacac ttcttcctcg ttgaccatcc ccatgggcac caccgcctca
     3061 cccacagagg gtatcggcac cgccagcgcc aacataagtg gtcggacgac tgaaacgaat
     3121 ggggcgcgca gtgtatagaa aagcggcgat gccgccaagg gctcccagta cgcagccctt
     3181 gtgaaagagg atcaacccgg tgcagaaaaa gaggaggcta acgggcaggt acgcactcga
     3241 ggcaggcggg attggcggca aagccgaacc gttcgtagat agcgcgccca tcactgctgg
     3301 catggagcca cagcttgccc agttgctgct cgcgggcata cgctaccatg gccaccagca
     3361 gggcattcgc cattccccgt ctgcgccagg ccggccgggt gtagatgttg agcaggtacc
     3421 cttcccgccc cgccatattg cccgggtagg gcgggcgcac gaagagtgcc agggtggcgc
     3481 acgccaccac ttcgccctcc tcttccacca cccagctacg ggcgctgccc tcttcctgcg
     3541 cctgaatgaa gtaggcctgc gtcgcctccc tgaggaccgg atcctcatcg ggccgggcaa
     3601 gttcccccac ctcgcaaaag agcgccatgc gcagtgtcgt cagggcagga atatcggccg
     3661 ccagggcctc gcgtaccttc atctcttctc ctttgcattc ctttcccgcc cgtcagtcag
     3721 gcagggctcg tgtgcggcca ccttacgccg gaggcgagcg acgggcaagg cgccagctgt
     3781 cgagccccag ggggcccgcc ccccacacgg ccagggtcag cagcatccag ccccacaact
     3841 ggtgatcgtg aaagcccccc gcccagaggg ccgggtagga gatgaccgcc atggcgttga
     3901 agccaaacag cagcaaggcg accggacggg tgaagaggcc cgccagcagg aagagaggca
     3961 gcaacagctc ggtcgccgtg cccgcatagg ccgcccactg ccagggcagc aggggtacct
     4021 gatattcgaa ctcgaacaga tagagggtgc tgtcccaggc cgtgaacttg agccagccgg
     4081 atcgcagaaa aatggtggcg acccagagcc tggcaagcag caacaggcca ccgctgcacc
     4141 agggcaagat gcgttcaaca agggggccaa ggggcctggc aagggtttgc gttgtcatgg
     4201 ggcaagctcc agatcgacca gcaggtcgag ggtgatgagg ggggccaggt gttcggccat
     4261 ggcgggatcc tgagccagca ggctggccag cggcctgccc tgcaggcagc cttgcagcag
     4321 acgccaggcg gcggcatcca ggggaatggg gtcgacccgg tgtccggggc gtttcttgag
     4381 tgccagggag cagacagcat ccagctccct gaccgtctca ccgccgtgca gggccatctg
     4441 ccagagcgcc agcaccggat gggggctctc caggagttgc agatcgcagg caggatgcag
     4501 caccagccgc tcccagtgct caggggtcat ggcggcaagc cgctcggcgg gccagcgccg
     4561 cgtctctggc gcaagcagcg aaacccgctc cagcccccac tcgaagcggg ccagatcccc
     4621 gagccagggc aacgcggccg tggtgggcaa gcgtgccagc cagtcgccaa agccctcccc
     4681 gtagtccatg acgctcccct cctccagagg tgccgccagc acgaaccctc gtgccgccgc
     4741 ctcaaagaag gtctcgccaa ccatggcgcg taccgcgggg tagctgctgg cgagcacctc
     4801 ggtgaggccg aggatgaagt tgttgcgata gatctgcaat agggcgtcgg gggcaaagcg
     4861 tcccggctgg atgtgcccga ggatggcatc atcctggccg agcagaccgc tcgcaaaagc
     4921 gcgttgcagg gaagcaagct cagacatggg cggcctcccc gagcagaccg ctcacaaaag
     4981 taccttgcgg gaaaacaagc tcagacaagg gcggcctccc tggatgtttg ctgcgccgcg
     5041 ctcaggatct cgctggcacg ctgcgcctct cccagcagca ccggcagcgg ggggatcgcc
     5101 agatcccatt caatcagggt ggggatggcg cgctgctggc agacctgctc gtagagcacc
     5161 cagacgggct cggccacggg ggtgctgtgg gtgtcgatat agaggggccc ctggggcagg
     5221 tgcttctcgg taaaaccggc caggtgaatt tcgccgaccg tgtcgaggtc gatagtcgcc
     5281 agatagtcgt ccacctccag gccgtgattg accgcgctca catggaggtt gttgagatcg
     5341 agcaggacgc cgcaaccgct gcgctcaacc agctcggcca gaaactcggc ctcccccatc
     5401 tcccccgcca gttgcaggta ggaggaggga ttctcgatga gcagttgtct gcccagtgtc
     5461 tgctgcaccc gatctatctt gtcgctcatg tacaaaagag tggcccgggt gtagggcatg
     5521 ggcagcagat cgttgaaata gcgcccgccg atgctgcccc agctcaggtg ctccgacacc
     5581 cgcaccggcg agatggccgc caccagggct gccagctggc gcaggtgccc ggcatcgagc
     5641 ggatcggcgg agcccagcga catgccgact ccgtgaaggc tcacggggta gtgcctcgca
     5701 agctccgcca gcacctcgaa gccctggttg tggcgctcga agtagttttc gctgtgtacc
     5761 tcaagccagc ccattccggg cagggtgtgg cggatctcgt cgtagtgcgg ggggcgtaaa
     5821 ccgataccga tcaaggggtt catggctggg ctctcaatag atagggccat gatgtggcgg
     5881 gcgccacacc atggcatgcg gcttacttgg gttgcaggga cccgccagcg agcttctcgc
     5941 acagcccctt gggcaccacc acgaaggcat ccccctgggc atccatcttg gcggtgccgg
     6001 cgcaggatcc gcccttggtg gcgcaatcgt tcttgcccgc cttaaccacg ccgtagcact
     6061 tctccttgtc atccgcagcc atggccggcg cggcgatgaa ctgggcaccc agggccagca
     6121 gccccgtcat ggcagaggcg atggcagtac tttttttcac gttcataggg acattcctta
     6181 ttgttgagcc tgacggctga tctttgcggt gtgaaagtgt tgccgggctt gtgcgccggc
     6241 taccccctat aaaaccggcg ccgggggaaa aagatttcat caaaagcgtg aattggcgaa
     6301 agtaaatggt ggaaacacag atagttaatt gtttttattg aaaatactgc cattgaaaaa
     6361 cacggggaaa tcctggcacg cggctcgccg ggcggcgacc accgagggga aatgcattga
     6421 ggggacgagt gacaacatca aacactgcat tgccatcaaa aaacctttca ttttcgctac
     6481 cagaaccatt cagacagcaa gagtcactgc cccactcccg ttgaaaagag aaagggacct
     6541 gggatccctt tcatcagagc accggcgatc aggccgtctt gacgcatttc tggatgaagc
     6601 tgttcttggc cgcccccgcc agcttcttgt cggcccccat gcccatcaca agcaccgtca
     6661 tcaggatcgc aatacctttc atatgacaag tcctcgttat tgatttgatt gtggttctgg
     6721 caacgagaga acgagcctca cccgatcccc tcttccggtt gcactattgt cctcccaccg
     6781 gctgaccacc agaacgctgt catttggata ctctctggcg cttgtcagaa agcggcccat
     6841 tgagcccgga agggtccgtc agagatggcg gaagtgtgag tgggaatctt cacatgatgt
     6901 gccgttcacc tgtcctttct actgccaacc cacttatagt gtcttgagtc tctccaccca
     6961 aaggtgtccc atgaatgctc cccatccccc cagatgcacc ctgtcgctgc ccatcttcat
     7021 cccgggtctg ctcttcatcc tgacgctgct ggccatctgc tccctggccc cggaggccgc
     7081 cgcccgcttc ttcggcagcg gccagagctg gatagcccag cacttcagct ggttctatgt
     7141 gctggtggtc ggcatgttcc tgatcctgct gctggtgatc gccttcagcc actttggcaa
     7201 cattcgcctc gggccggacg atgcccgccc ggagttcagc ttcacctcct ggctcgccat
     7261 gctgttcgcc gctggcatgg ggataggcct catgtatttc ggggtgggcg agcccatgag
     7321 ccactacgtc tcgccgcccc aggcgacgcc cctgacgccg gtggccgccc gcgaggccat
     7381 ggtcaccacc ttcttccact ggggctttca tgcctgggcc gtctacgcca tcgtcggcct
     7441 ggtgctggcc tacttcggct ttcgctacaa cctgcccctg accatccgct ccggcctcta
     7501 ccccatcttc aaggagaaga tccacgggcc gctcggccac gcggtggacg tcttcgccct
     7561 ggtgggcacc atctttggta tcgccaccac cctgggctac ggcgtgatgc agctctcggc
     7621 ggggatcacc cggctcaccg gcatggacac ctcgggggac ctgttccgct tcggcctcat
     7681 cggggccgtc atcgccctcg ccggcgtctc tgcggtcacc gggctcgaca agggggtcaa
     7741 acgcctctcc gagctgaacc tcttcctcgc catcgtgctc ctgctgttcg tgctggtggc
     7801 cggccccacc aagtacctgc tgggagccct ctcggagaac attggcaact atgtctcctc
     7861 tttaagccag ctcaccttcc gcaccttcac ctacagcgag acccgccagg cgggctggtt
     7921 cggcaactgg accctgctct actgggcctg gtggatctcc tggtccccct tcgtcggtct
     7981 cttcatcgcc cgcatctccc gcggacgcac cctgcgcgaa ttcatcctcg gcgtcctgtt
     8041 cgtccccacc gccttcaacc tgctctggat gacggtgttc ggcaacgccg ccatctgggc
     8101 cagccagcat gaggggggca caagcctcat cgactcggtc ggcaacatcg acaccctgct
     8161 gttcaacttc tttgacctct tgccgggagc ggacatcacc tcggcgctcg cagtgatcct
     8221 catcagcgtc ttcttcgtca cctccgccga ctcgggagcc ttcgtcatcg acaacatcgc
     8281 tacccagggc aaggagggct caccggtctg gcagcgcctg ttctgggctc tgctgctcgg
     8341 ggtcaccgcg ggtaccctga tgagcacagg ggggctggcg gcgctccagt ccatgaccct
     8401 catcgccgcc ctgccgtttg ccttcatcat ggtgctgctc tgcctcggac tctgccgcgg
     8461 ccttgtcgca gacaaggagc actcggccag gcgcctctcc cccgccactg acttctggaa
     8521 cggcaagcag tggcgcaccc ggatggatca cctgctgcgc ccctccaccg agcaggaggc
     8581 ccgcgccttt gtggacaagg tcgccctgcc cgctctgacg gccctgagtc aggagttcgc
     8641 tgcccggggc atcaccagcc gggtcgaaga ggatgggccg gatcagtgcc atctgctggt
     8701 gccccagcag ggtcgccggg acttctgcta cggggtgcgc atcgaggccc gccccgcccc
     8761 cgccttcaac cccctggagg cggcccacaa ccacgatccc gaggcccgca tcttcgagcc
     8821 catcacctat tttgccgatg gccgtgccgg ttacgacatc cagtacctga cccgggacga
     8881 actgagtgcc gacgtcttgc gccagtacga gcgctatctg gtgctgagcc aggacgaggg
     8941 gcaggatctg ctgagcagcg cccccgaaca tacccagcca acccagggag agtgatgacc
     9001 aggcagggat caagtcagct ccccgcccgg agcttatggc cgggcacact ggcggcgagg
     9061 gctgccccca ccacccatca caacagagaa aggggcccca gggccccttt ctcgtcactg
     9121 cctcaacctg cgttgatttc agagcctcac cggctcaggc ggttttcacg cacttctgga
     9181 taaagctgtt cttggccgcc ccggcgagct tcttgtccgc cgccgccttc tcgcactggg
     9241 tcgccttgtc ggcggccccg tccgtcttca gacacttttg cacgaagctg ttcttggccg
     9301 cgccagccag cttcttgtcg gcggccgctt tctcacactg actcgccttg gcactggcgg
     9361 aggcatcctt gacgcacttg cccacaaagc tggtcttggc ggcgcccgcc agcttcttca
     9421 ccgccgcctg ggcctcgcac tcttgctgcg cgccagaggt cgcgctctgg gctaccccca
     9481 tccccatgcc catgaccgtc acacacagac tcaacaccat caggatccgc ttcatatgtc
     9541 acactcccat cgttctatcc attgtggttg gcccccactc acgcgggcca aacgaggcac
     9601 ccttgcctcg ctgcactata gtcccccctc cccgtgacaa caaaatgccc ttccttgccg
     9661 acaaccccct ccttgccccc gctccggcca cccggcgcct tcacttcaat tgttgagctg
     9721 gcgcaaaaat ccagcgcttc cttgcggttg cgtcaacttt tgactggttt gcgtatgagg
     9781 cttgaggata tgctagccat tcggcgccta ctgcaccatt cgggccccgc ccgctggtta
     9841 atggagcgca ttggaagctg taatccaggg gcggtagcgt ggcggcttag tgaagcggtg
     9901 tatcgtgatg aaattaggta tccgatttat gcacgattga catccaacat atcgaaaaat
     9961 aagaatttga ggcacatgtg aaaataatac ttttcagagc taaaaaggtt cacgaacagt
    10021 ttaatttttc tataaatttc aataatgatc ttaacttcat cactggaata aatggcacag
    10081 gaaaaaccac agcactgaag ttaatgaaag ctgcaattac atttgacctg cacattctaa
    10141 tttccatatc tttctccaca ttgacaatgg aaatagagca cgcaggtaaa ctatattcaa
    10201 tagagataca gaagaagaat ggggccatca cgatcaattt aaatgacaac atcataaata
    10261 ttgaagacgc gctgcttaac gaaagttcaa acttggttta tgaaaaccac cgggatttta
    10321 ttgatagtct attccacaat aaaatcatta atggtaatga aatttacaga agttttttga
    10381 aagaaataaa gcctttgttt ttggggctcg atcggcaaat ggattactct gacgatgacg
    10441 agtattttct caagaatcat tatatatcaa ggcgaattaa ggctgagcga aaacctaatg
    10501 ttgatggtct tgaaaattgc aaaaaattaa ttgaagatgc atacagaaag tatcgccgag
    10561 ttagtgatgg cagtctggat agaattgtta gcgtgattat aggctccagc ttcgattata
    10621 ttgatattga tcactcagaa attttcagct cacattttag ccctagagtt gaactacaaa
    10681 aactaaagga aagacaggaa gacttacaga cgttcacgag tagaataggt ttatcccatc
    10741 aagcatcaaa gcaaatagat aaatttttca ctcaaatgtc tgaggccctt aacaattatg
    10801 atagtgagcg gggagaacat gttggcattg aatggctaat aaa
//
