GCF_016026875.1_ASM1602687v1_genomic - 4 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP065651.1

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	hserlactone	991,530	1,012,153
Region 2	arylpolyene	1,475,375	1,518,971	aryl polyenes	Other	61%
Region 3	RiPP-like	1,812,275	1,823,123
Region 4	NRPS	2,510,713	2,560,913	amonabactin P 750	NRP	100%

NZ_CP065651.1 - Region 1 - hserlactone

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Location: 991,530 - 1,012,153 nt. (total: 20,624 nt) Show pHMM detection rules used

hserlactone: Autoind_synth

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000703.1	0.14	Saccharide	kanamycin	Streptomyces kanamyceticus
BGC0001440.1	0.09	Other	cystargolide A, cystargolide B	Kitasatospora cystarginea
BGC0000807.1	0.08	Saccharide	phosphonoglycans	Stackebrandtia nassauensis DSM 44728
BGC0001106.1	0.06	NRP, Polyketide	oxalomycin B	Streptomyces albus
BGC0000961.1	0.06	NRP, Polyketide	bactobolin	Burkholderia thailandensis E264
BGC0000376.1	0.05	NRP	JBIR-34, JBIR-35	Streptomyces sp. Sp080513GE-23
BGC0001543.1	0.05	Polyketide	chejuenolide A, chejuenolide B	Hahella chejuensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000703.1	0.42	Saccharide	kanamycin	Streptomyces kanamyceticus
BGC0001440.1	0.33	Other	cystargolide A, cystargolide B	Kitasatospora cystarginea
BGC0000807.1	0.30	Saccharide	phosphonoglycans	Stackebrandtia nassauensis DSM 44728
BGC0001106.1	0.25	NRP, Polyketide	oxalomycin B	Streptomyces albus
BGC0000961.1	0.25	NRP, Polyketide	bactobolin	Burkholderia thailandensis E264
BGC0000376.1	0.23	NRP	JBIR-34, JBIR-35	Streptomyces sp. Sp080513GE-23
BGC0001543.1	0.23	Polyketide	chejuenolide A, chejuenolide B	Hahella chejuensis

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NZ_CP065651.1 - Region 2 - arylpolyene

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Location: 1,475,375 - 1,518,971 nt. (total: 43,597 nt) Show pHMM detection rules used

arylpolyene: (APE_KS1 or APE_KS2)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002008.1	0.39	Other	aryl polyenes	Xenorhabdus doucetiae
BGC0000836.1	0.34	Other	APE Ec	Escherichia coli CFT073
BGC0000837.1	0.33	Other	APE Vf	Aliivibrio fischeri ES114
BGC0000375.1	0.24	NRP	indigoidine	Streptomyces chromofuscus
BGC0001197.1	0.23	Polyketide	frankiamicin	Frankia sp. EAN1pec
BGC0000234.1	0.23	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000272.1	0.22	Polyketide	spore pigment	Streptomyces collinus
BGC0000889.1	0.21	Other	bagremycin A, bagremycin B	Streptomyces sp. WK-5344
BGC0000248.1	0.21	Polyketide	naphtocyclinone	Streptomyces arenae
BGC0000194.1	0.21	Polyketide	actinorhodin	Streptomyces coelicolor A3(2)

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002008.1	0.71	Other	aryl polyenes	Xenorhabdus doucetiae
BGC0000836.1	0.67	Other	APE Ec	Escherichia coli CFT073
BGC0000837.1	0.67	Other	APE Vf	Aliivibrio fischeri ES114
BGC0000375.1	0.58	NRP	indigoidine	Streptomyces chromofuscus
BGC0001197.1	0.56	Polyketide	frankiamicin	Frankia sp. EAN1pec
BGC0000234.1	0.56	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000272.1	0.54	Polyketide	spore pigment	Streptomyces collinus
BGC0000889.1	0.54	Other	bagremycin A, bagremycin B	Streptomyces sp. WK-5344
BGC0000248.1	0.54	Polyketide	naphtocyclinone	Streptomyces arenae
BGC0000194.1	0.53	Polyketide	actinorhodin	Streptomyces coelicolor A3(2)

Similar known gene clusters

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NZ_CP065651.1 - Region 3 - RiPP-like

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Location: 1,812,275 - 1,823,123 nt. (total: 10,849 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	RiPP-like	Similarity score	Type	Compound(s)	Organism
BGC0000506.1		0.04	RiPP	entianin	Bacillus subtilis subsp. spizizenii
BGC0001791.1		0.03	NRP	sunshinamide	Gynuella sunshinyii YC6258

Reference	Aggregated	Similarity score	Type	Compound(s)	Organism
BGC0000506.1		0.18	RiPP	entianin	Bacillus subtilis subsp. spizizenii
BGC0001791.1		0.16	NRP	sunshinamide	Gynuella sunshinyii YC6258

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NZ_CP065651.1 - Region 4 - NRPS

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Location: 2,510,713 - 2,560,913 nt. (total: 50,201 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001502.1	0.78	NRP	amonabactin P 750	Aeromonas hydrophila subsp. hydrophila ATCC 7966
BGC0000426.1	0.37	NRP	sevadicin	Paenibacillus larvae
BGC0000389.1	0.33	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0000457.1	0.31	NRP	vicibactin	Rhizobium etli CFN 42
BGC0000351.1	0.28	NRP	exochelin	Mycolicibacterium smegmatis
BGC0001050.1	0.27	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0001479.1	0.27	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0001671.1	0.27	NRP	monobactam	Agrobacterium tumefaciens
BGC0001434.1	0.27	NRP	nematophin	Xenorhabdus budapestensis
BGC0001698.1	0.27	NRP	nevaltophin A, nevaltophin B, nevaltophin C, nevaltophin D	Xenorhabdus budapestensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001502.1	0.92	NRP	amonabactin P 750	Aeromonas hydrophila subsp. hydrophila ATCC 7966
BGC0000426.1	0.70	NRP	sevadicin	Paenibacillus larvae
BGC0000389.1	0.67	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0000457.1	0.65	NRP	vicibactin	Rhizobium etli CFN 42
BGC0000351.1	0.62	NRP	exochelin	Mycolicibacterium smegmatis
BGC0001050.1	0.61	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0001479.1	0.61	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0001671.1	0.61	NRP	monobactam	Agrobacterium tumefaciens
BGC0001434.1	0.61	NRP	nematophin	Xenorhabdus budapestensis
BGC0001698.1	0.61	NRP	nevaltophin A, nevaltophin B, nevaltophin C, nevaltophin D	Xenorhabdus budapestensis

Similar known gene clusters

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Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 4, location 2510712 - 2560913:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (D-X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_2238

Search NORINE for peptide: strict or relaxed

AMP-binding (38..446): dhb

NRPSPredictor2: dhb

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: dhb, sal
Small clusters prediction:: dhb, sal
Single AA prediction:: dhb

Stachelhaus prediction details:

Stachelhaus sequence:: PLPsQGVVNK
Nearest Stachelhaus code:: dhb
Stachelhaus code match:: 90% (moderate)

ctg1_2240

Search NORINE for peptide: strict or relaxed

AMP-binding (456..855): X

NRPSPredictor2: asp, asn, glu, gln, aad

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAeDIGtVvK
Nearest Stachelhaus code:: glu
Stachelhaus code match:: 70% (weak)

ctg1_2242

Search NORINE for peptide: strict or relaxed

AMP-binding (537..923): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAmigGMVtK
Nearest Stachelhaus code:: leu
Stachelhaus code match:: 60% (weak)

ctg1_2243

Search NORINE for peptide: strict or relaxed

AMP-binding (35..422): gly

NRPSPredictor2: gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DILQLGcVWK
Nearest Stachelhaus code:: gly
Stachelhaus code match:: 90% (moderate)