LOCUS       c00010_NZ_ATVI..       10849 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_ATVI01000010.1 Nevskia ramosa DSM 11499
            G513DRAFT_scaffold00006.6_C, whole genome shotgun sequence.
ACCESSION   NZ_ATVI01000010
VERSION     NZ_ATVI01000010
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 15:04:23
            Original ID  :: NZ_ATVI01000010.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 100136
            Orig. end    :: 110985
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10849
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[105136:105985](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5849
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10849
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10849
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             693..2189
                     /locus_tag="ctg10_79"
                     /transl_table=11
                     /translation="MPETTQAEQKEAVASTGIDSLDDILDGGYRKNRLYLIEGVPGSGK
                     TTLALQFLLDGASRNEPTLYITLSESAEELGAIAESHGWSLDGIAVRELVPSEAVLRPD
                     DHYTMFHPSEVELGETTRTILEEVDRINPKRVVFDSLSELRLIAGSPLLYRRQILALKH
                     FFAGRNCTVLMLDDMTSSDRDLQVQSIAHAVVLLEQANPDYGVERRRLRVVKYRGVNFR
                     GGYHDYAIRQGGLVVFPRLVATEHRKLPSRQRLPSGIAELDTLLGGGVERGTSTLLSGA
                     AGTGKSSVAAQFVYAAAERGETAAMFIFDESIDTLLSRTSALHIDLQKHVDSGRVTIKP
                     IDPAELSPGELVHAIRKSVDERSVSMIVIDSLNGYLNAMPGERFLMIQLHELLSFLGHS
                     DVATLLVSAHQGLIGSNMTSPVDVSYLADAVILMRYFESEGEVRQAISVVKKRGGAHER
                     SIREFRMNDGNIVVGEPLRNFRGILTGVPIYQEAMARIEP"
     PFAM_domain     735..1412
                     /aSDomain="ATPase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF06745.15"
                     /description="KaiC"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg10_79_0001"
                     /evalue="8.50E-40"
                     /label="ctg10_79"
                     /locus_tag="ctg10_79"
                     /protein_end="240"
                     /protein_start="14"
                     /score="136.6"
                     /tool="antismash"
                     /translation="STGIDSLDDILDGGYRKNRLYLIEGVPGSGKTTLALQFLLDGASR
                     NEPTLYITLSESAEELGAIAESHGWSLDGIAVRELVPSEAVLRPDDHYTMFHPSEVELG
                     ETTRTILEEVDRINPKRVVFDSLSELRLIAGSPLLYRRQILALKHFFAGRNCTVLMLDD
                     MTSSDRDLQVQSIAHAVVLLEQANPDYGVERRRLRVVKYRGVNFRGGYHDYAIRQGGLV
                     VFPR"
     PFAM_domain     1458..2117
                     /aSDomain="ATPase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF06745.15"
                     /description="KaiC"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg10_79_0002"
                     /evalue="3.50E-30"
                     /label="ctg10_79"
                     /locus_tag="ctg10_79"
                     /protein_end="475"
                     /protein_start="255"
                     /score="105.2"
                     /tool="antismash"
                     /translation="PSGIAELDTLLGGGVERGTSTLLSGAAGTGKSSVAAQFVYAAAER
                     GETAAMFIFDESIDTLLSRTSALHIDLQKHVDSGRVTIKPIDPAELSPGELVHAIRKSV
                     DERSVSMIVIDSLNGYLNAMPGERFLMIQLHELLSFLGHSDVATLLVSAHQGLIGSNMT
                     SPVDVSYLADAVILMRYFESEGEVRQAISVVKKRGGAHERSIREFRMNDGNIVVGEP"
     CDS             2200..3765
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 94; E-value: 1.6e-28)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg10_80"
                     /transl_table=11
                     /translation="MTSSSELRVLVVGPTSRDAQLVRAVLAENGIASESCASLVELCSE
                     LEARGAGAILVAEETLSRAECLSTWMQAQPTWSDLPLLVIARPGADSAIVASVMARLGS
                     VAILERPTRVSALLSSVQVALRARKRQYQIRDQLADLENARATLQRNDHRKDEFLAILA
                     HELRNPLAPISNALELLKRADSSDPMLQKIGQMMTRQVGNLNRLVDDLLEISRITRDKI
                     ELKKVTVTLDSILQTAIEASQPLLDTHRHQLHVSLPSGLPLLLADPLRLSQVFANLLNN
                     AAKFTEPGGQIWLSVQQEPKALSISVRDNGIGIRPDMQARIFELFAQADEITSRSQGGL
                     GIGLMLVRRLVELHGGTVKVISEGPGQGSEFIVRLPLTGNLTQTVSAPLAKPSSPAGLG
                     QQRILVVDDNLDAASSLCQLLELWGAETQVAGSGQEALDILGDFRPDVAILDIGMQGMD
                     GLELAGRIRARPELSGLFLIALTGWGQEEDIRRTLKSGFDRHLVKPVNLELLQTLLREH
                     PRPP"
     PFAM_domain     2662..2853
                     /aSDomain="HisKA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00512.27"
                     /description="His Kinase A (phospho-acceptor) domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg10_80_0003"
                     /evalue="1.00E-13"
                     /label="ctg10_80"
                     /locus_tag="ctg10_80"
                     /protein_end="218"
                     /protein_start="154"
                     /score="51.2"
                     /tool="antismash"
                     /translation="KDEFLAILAHELRNPLAPISNALELLKRADSSDPMLQKIGQMMTR
                     QVGNLNRLVDDLLEISRIT"
     PFAM_domain     2998..3333
                     /aSDomain="HATPase_c"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02518.28"
                     /description="Histidine kinase-, DNA gyrase B-, and
                     HSP90-like ATPase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg10_80_0004"
                     /evalue="2.40E-29"
                     /label="ctg10_80"
                     /locus_tag="ctg10_80"
                     /protein_end="378"
                     /protein_start="266"
                     /score="102.2"
                     /tool="antismash"
                     /translation="DPLRLSQVFANLLNNAAKFTEPGGQIWLSVQQEPKALSISVRDNG
                     IGIRPDMQARIFELFAQADEITSRSQGGLGIGLMLVRRLVELHGGTVKVISEGPGQGSE
                     FIVRLPLT"
     PFAM_domain     3406..3741
                     /aSDomain="Response_reg"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00072.26"
                     /description="Response regulator receiver domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg10_80_0005"
                     /evalue="3.90E-21"
                     /label="ctg10_80"
                     /locus_tag="ctg10_80"
                     /protein_end="514"
                     /protein_start="402"
                     /score="75.4"
                     /tool="antismash"
                     /translation="ILVVDDNLDAASSLCQLLELWGAETQVAGSGQEALDILGDFRPDV
                     AILDIGMQGMDGLELAGRIRARPELSGLFLIALTGWGQEEDIRRTLKSGFDRHLVKPVN
                     LELLQTLL"
     CDS             complement(3796..4272)
                     /locus_tag="ctg10_81"
                     /transl_table=11
                     /translation="MRTFVADISETLLKLTDRLDWLAPLAMRLGFGYFWLETGWAKLHN
                     LDGFTERFVSWGLPFPAFSAGLSAWTEFLGGGLIMLGLLTRLVSIPMLINMVVAIAFVV
                     IKDVTDVDSFFELDEVIYILIFGWLIMAGPGEVSVDTLISKWLGLDDRRAARTP"
     PFAM_domain     complement(3964..4203)
                     /aSDomain="DoxX"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07681.14"
                     /description="DoxX"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg10_81_0006"
                     /evalue="2.30E-15"
                     /label="ctg10_81"
                     /locus_tag="ctg10_81"
                     /protein_end="103"
                     /protein_start="23"
                     /score="57.1"
                     /tool="antismash"
                     /translation="PLAMRLGFGYFWLETGWAKLHNLDGFTERFVSWGLPFPAFSAGLS
                     AWTEFLGGGLIMLGLLTRLVSIPMLINMVVAIAFV"
     CDS             4678..4938
                     /locus_tag="ctg10_82"
                     /transl_table=11
                     /translation="MNTVKMTSIALATAAAGLFSTVAINVAYAADAAGVKCEHASSCKG
                     QGACKQASNSCKGQNACKGQGFTEVKSAADCTKAQADAKKS"
     CDS             5001..5849
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg10_83"
                     /sec_met_domain="DUF692 (E-value: 8.3e-107, bitscore:
                     350.2, seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATNASTTPLAPLGFGLGLRVQHYEEILESDPAIDWLEILSENYL
                     IPGGRPLHYLARFRERYPLVMHGVSLSIGSTDPLDRSYLKQLKALADLVQPAWISDHLC
                     WTGVAGNNLHDLMPLPYTEEAIKHVADRVQQVQDALGRRILLENVSSYVTYSHSTMPEW
                     EFLTAVAEAADSLILLDINNIYVSGHNHGFDPRRYLDSVPPDRVQQFHLAGHDYQGALI
                     IDTHDAPVPEPVWDLYAHAVRRFGAVSTMIERDDKIPPLAELLAELDRAREIAQPILKV
                     A"
     PFAM_domain     5040..5825
                     /aSDomain="DUF692"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05114.15"
                     /description="Protein of unknown function (DUF692)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg10_83_0007"
                     /evalue="1.50E-113"
                     /label="ctg10_83"
                     /locus_tag="ctg10_83"
                     /protein_end="275"
                     /protein_start="13"
                     /score="378.5"
                     /tool="antismash"
                     /translation="GFGLGLRVQHYEEILESDPAIDWLEILSENYLIPGGRPLHYLARF
                     RERYPLVMHGVSLSIGSTDPLDRSYLKQLKALADLVQPAWISDHLCWTGVAGNNLHDLM
                     PLPYTEEAIKHVADRVQQVQDALGRRILLENVSSYVTYSHSTMPEWEFLTAVAEAADSL
                     ILLDINNIYVSGHNHGFDPRRYLDSVPPDRVQQFHLAGHDYQGALIIDTHDAPVPEPVW
                     DLYAHAVRRFGAVSTMIERDDKIPPLAELLAELDRAREIA"
     CDS             5846..6652
                     /locus_tag="ctg10_84"
                     /transl_table=11
                     /translation="MSGLAQLQHDFSAYLLRDDASICSLIVGDRTAALEQRVNVYRDGY
                     RLRLIEVLTGDFPGLLHLLGAADFDALCRDYIDAHPSTHFNIRWFGGRLPDFLSGSPCG
                     SQRPAVVEMAVLEWTLTLAFDAVDEVSVTMADAAALTAEQWPGMKLRMAAAVQRRQFVA
                     NVGAIRRAIDREETPPAVETFDAHRQWVVWRLDRGVYQRQMDADEAAAFDGAAAGASFA
                     EICAILCEWHAEERVAIQAAGFLKLWIEQQWIAELIVDLITDHDAR"
     PFAM_domain     5861..6139
                     /aSDomain="DUF2063"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09836.11"
                     /description="Putative DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg10_84_0008"
                     /evalue="2.20E-22"
                     /label="ctg10_84"
                     /locus_tag="ctg10_84"
                     /protein_end="98"
                     /protein_start="5"
                     /score="79.2"
                     /tool="antismash"
                     /translation="QLQHDFSAYLLRDDASICSLIVGDRTAALEQRVNVYRDGYRLRLI
                     EVLTGDFPGLLHLLGAADFDALCRDYIDAHPSTHFNIRWFGGRLPDFL"
     CDS             6642..8423
                     /locus_tag="ctg10_85"
                     /transl_table=11
                     /translation="MRADRRGTWGAALMIVAGLFGLPAHAAGDGIPWRNWSDDLFAQSQ
                     REHKLVLLDLEAVWCHWCHVMDQQTYRDAAVIKLLRERYITVKVDQDSRPDLSNRYEDY
                     GWPATIIYAPDGRELVKRSGYIPPAGMVSLLQAVIDDPTPGPSITPEVKPDFSAAVIAS
                     SLRGTLEKLVVEQYDAEHGGWGFSQKFLDADSVEYCLQQSRRGDADATRMARQTLDAQR
                     KLLDPVWGGVYQYSTGGDWLTPHFEKIMSMQANNLRIYALAWAQFHDPADLKAAQAIRD
                     YLARFLTRADGAFLTSQDADVVPGEHAADYFALADAARRARGVPAVDSHVYARENGWAI
                     EALAMLHAASGEPGDLQAAIKAAGVIVEQRSLPGGGFRHDQHDPAGPYLGDTLAMGQAF
                     LALYSASGDRRWLARAQSAAQFIDAHFAGHRQPGYRTAASRKGAAPAQPLRDENVRMAR
                     FANRLFRYTGDARYQQSAQRAMRFIAAPEIARRFPAAGALLASDELSREPLHFTVVGNK
                     DDAVAAALFATAAAFPSAYTRTEWWDRREGSLANSDVQYPRFPKAAAYICTERSCSLPI
                     FEPPAFSIRLATLAHAP"
     misc_feature    6705..6707
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     PFAM_domain     6720..7034
                     /aSDomain="Thioredox_DsbH"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03190.17"
                     /description="Protein of unknown function, DUF255"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg10_85_0009"
                     /evalue="2.40E-24"
                     /label="ctg10_85"
                     /locus_tag="ctg10_85"
                     /protein_end="131"
                     /protein_start="26"
                     /score="86.2"
                     /tool="antismash"
                     /translation="AGDGIPWRNWSDDLFAQSQREHKLVLLDLEAVWCHWCHVMDQQTY
                     RDAAVIKLLRERYITVKVDQDSRPDLSNRYEDYGWPATIIYAPDGRELVKRSGYIPPAG
                     M"
     CDS             8496..9440
                     /gene_functions="other (smcogs) SMCOG1108:ROK family
                     protein (Score: 185.4; E-value: 3e-56)"
                     /gene_kind="other"
                     /locus_tag="ctg10_86"
                     /transl_table=11
                     /translation="MFRVGIDLGGTKIEGIVLRGAAEVVARQRIATPGGDYAATVAAVA
                     ALVSALEREVGVHELPVGIGHPGAISPFTGLIKNANSTCLNDRPLKADLEAALGREARM
                     ANDADCLALSESQADGAAAGAACVFAVILGTGVGGGIVIDGKLRAGPNAIAGEWGHNPL
                     PWPRADWHEVPGPLGWDGRHGSIEDWCSGVALARDHLEVSGENLRGEEVVARAEAGNAT
                     GIATLARYEDRLARALASVINLLDPDVIVLGGGLSRVARLYQTVPQLWRAWVFSDQVAT
                     RLLPATHGDSSGVRGAAWLWPLAEPDQTRNPRT"
     PFAM_domain     8505..9398
                     /aSDomain="ROK"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00480.22"
                     /description="ROK family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg10_86_0010"
                     /evalue="2.00E-64"
                     /label="ctg10_86"
                     /locus_tag="ctg10_86"
                     /protein_end="301"
                     /protein_start="3"
                     /score="218.0"
                     /tool="antismash"
                     /translation="VGIDLGGTKIEGIVLRGAAEVVARQRIATPGGDYAATVAAVAALV
                     SALEREVGVHELPVGIGHPGAISPFTGLIKNANSTCLNDRPLKADLEAALGREARMAND
                     ADCLALSESQADGAAAGAACVFAVILGTGVGGGIVIDGKLRAGPNAIAGEWGHNPLPWP
                     RADWHEVPGPLGWDGRHGSIEDWCSGVALARDHLEVSGENLRGEEVVARAEAGNATGIA
                     TLARYEDRLARALASVINLLDPDVIVLGGGLSRVARLYQTVPQLWRAWVFSDQVATRLL
                     PATHGDSSGVRGAAWLW"
     misc_feature    9393..9395
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS             complement(9416..10321)
                     /NRPS_PKS="Domain: Thioesterase (84-210). E-value: 3.1e-10.
                     Score: 32.7. Matches aSDomain:
                     nrpspksdomains_ctg10_87_Thioesterase.1"
                     /NRPS_PKS="type: other"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1066:alpha/beta hydrolase domain-containing protein
                     (Score: 252.1; E-value: 1.1e-76)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg10_87"
                     /transl_table=11
                     /translation="MTSSLSLRARLFGPVSQFLLQPVLAKPAHEMRPQLERIARLITHV
                     PRGTRIEATTLAGRPADRLTPSGDSGDQVIYYLHGGAYLGGSTRTHRGLLAHFAKAAGC
                     EVVAIDYRLAPEHPYPAALEDAVAGYQELLAEGIPAERIVIAGDSAGGNLALVTAIALR
                     DAGMALPAGLVLLSPWTDMSSSGKSMGSRAERDRILTVLGISKAAETFAAGRKLADPLL
                     SPLFADLAGLPPMLIQVGDDELLLDDSTRLTAAARKAGVQVLLSVRPKLWHVWQAMAGW
                     MPEADQAIREMGDYVRGLRV"
     PFAM_domain     complement(9497..10096)
                     /aSDomain="Abhydrolase_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07859.15"
                     /description="alpha/beta hydrolase fold"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg10_87_0011"
                     /evalue="1.20E-55"
                     /label="ctg10_87"
                     /locus_tag="ctg10_87"
                     /protein_end="275"
                     /protein_start="75"
                     /score="188.8"
                     /tool="antismash"
                     /translation="YYLHGGAYLGGSTRTHRGLLAHFAKAAGCEVVAIDYRLAPEHPYP
                     AALEDAVAGYQELLAEGIPAERIVIAGDSAGGNLALVTAIALRDAGMALPAGLVLLSPW
                     TDMSSSGKSMGSRAERDRILTVLGISKAAETFAAGRKLADPLLSPLFADLAGLPPMLIQ
                     VGDDELLLDDSTRLTAAARKAGVQVLLSVRPKLWHVW"
     aSDomain        complement(9692..10069)
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg10_87_Thioesterase.1"
                     /evalue="3.10E-10"
                     /label="ctg10_87_Thioesterase.1"
                     /locus_tag="ctg10_87"
                     /protein_end="210"
                     /protein_start="84"
                     /score="32.7"
                     /tool="antismash"
                     /translation="GGSTRTHRGLLAHFAKAAGCEVVAIDYRLAPEHPYPAALEDAVAG
                     YQELLAEGIPAERIVIAGDSAGGNLALVTAIALRDAGMALPAGLVLLSPWTDMSSSGKS
                     MGSRAERDRILTVLGISKAAET"
ORIGIN
        1 ttcaacccgg tggcgagtgc ggcggacttc ggcacccgcg gcaatgccga ctacctgaac
       61 tacgcgctcg aacagcgcgg caacggcgac gccggcaccc tggcgccgga tatcgccacc
      121 gagctggcca agctgctcgc cgccgatctg gtgatcttca gcttcccgct gtactggttc
      181 tcggtgccgg cgattctcaa gggctggatc gatcgcgtgc tggtgtccgg caagacctac
      241 ggcggccggc gcatctacga tcagggcggg ctgaagggca agcgcgcgct gctggcgctg
      301 accaccggcg gccgcgatta catgctcagc gaaggcggca tccacggcga catcgaagac
      361 atcctcaagc cggtactgca gggcacgctg gcctataccg gcatgaccgt gctgcccagc
      421 ttcgtcggct tccacgtgcc gtatctgaag caggaagagc gcgccgcgat cctggaaaac
      481 ttccgcgccc atctggccag gctcgacacg ctgacgccgc tgagtttccc gaagctggcc
      541 gacttcgatg cccagatgaa gccgctgacc aagtagcccg acggcagaaa agctgccctg
      601 ttctgtgctc taccgcacca agttcaaccg cattttttcc gcatggctct gtccaagcca
      661 tcacttgaaa atcgagagag tggtactgac ccatgccgga aacgacccag gcagagcaga
      721 aagaagcagt agcgagtacg ggcatcgaca gcctggacga cattcttgac ggcggctatc
      781 ggaagaaccg cctgtacctg atcgagggtg tgccgggttc cggcaagacc accctggcgc
      841 tgcagttcct gctggacggc gcgagccgca acgagccgac gctgtacatc acgctgtcgg
      901 agtccgccga ggagctgggc gcgatcgccg aatcgcacgg ctggtcgctg gacgggatcg
      961 ccgtgcgcga actggtgccg tccgaggcgg tgctgcggcc ggacgatcac tacacgatgt
     1021 ttcatccgtc cgaggtggaa ctcggcgaaa ccacgcgcac cattctcgaa gaagtggacc
     1081 ggatcaatcc caagcgggtg gtcttcgatt cgctctccga actgcgcctg atcgccggca
     1141 gcccgctgct ctaccgccgg cagattcttg ccctcaagca tttcttcgcc ggccgcaatt
     1201 gcacggtgct gatgctcgat gacatgacca gttccgatcg cgacctgcag gtgcagagca
     1261 tcgcgcacgc ggtggtactg ctcgagcagg ccaatcccga ttacggcgtc gagcggcgcc
     1321 ggttgcgcgt ggtcaagtac cgcggcgtga acttccgtgg cggctatcac gactacgcga
     1381 tccgccaagg cggcctcgtc gtctttcctc gtctggtcgc caccgaacac cgcaaattgc
     1441 cgagccggca gaggttgccg agcgggatcg ccgaactgga tacgctgctc ggcggcggcg
     1501 tcgagcgcgg caccagcacc ttgctgtccg gcgcggcagg taccggaaag tcgtcggtgg
     1561 cggcgcagtt cgtttatgcg gcggcggagc gcggcgagac tgcggcgatg ttcatcttcg
     1621 acgagagcat cgacaccctg ttgagccgca cttcggcgct gcatatcgat ctgcagaagc
     1681 atgtcgactc cgggcgcgtc accatcaagc cgatcgaccc ggcggaactc tcgccgggcg
     1741 aactcgttca tgcgatccgc aagagcgtcg atgagcgcag cgtttcgatg atcgtcatcg
     1801 acagcctgaa cggctatctg aacgccatgc ccggcgagcg tttcctgatg attcagctgc
     1861 acgagctgct gagcttcctc ggtcactccg atgtcgcgac cctgctggtc agcgcgcatc
     1921 aggggctgat cggcagcaac atgacctcgc cggtggacgt cagttatctg gccgacgcgg
     1981 tgatcctgat gcgctacttc gaatccgaag gcgaagttcg ccaagccatt tcggtggtca
     2041 agaaacgcgg tggtgcccat gagcgcagca tccgcgaatt ccgcatgaac gacggcaaca
     2101 tcgtggtggg cgaacccctg agaaatttcc gcggcatcct gacgggagtg ccgatctatc
     2161 aggaggcgat ggcgcggatc gaaccttgat ccgcacgtca tgacttccag cagcgaattg
     2221 cgggtactgg tggtagggcc caccagccgg gacgcccaac tggtgcgcgc ggtcctggcc
     2281 gaaaacggta tcgccagcga gtcttgcgcc tcgctggtgg agctgtgttc ggaactcgag
     2341 gcgcgtggcg ccggcgccat cctggtggcc gaggagaccc tgagccgggc cgaatgcctg
     2401 agtacctgga tgcaggctca gccgacctgg tccgatctgc cgctgctggt catcgccagg
     2461 ccgggcgccg attcggcgat cgtcgcctcg gtgatggcgc ggctcggcag cgtggcgatc
     2521 ctggagcggc cgacgcgcgt gtcggctctg ctcagttcgg tgcaggtggc cctgcgcgcc
     2581 cgcaagcgcc agtaccagat tcgcgatcag ctggccgatc tcgaaaacgc ccgcgccacg
     2641 ctgcagcgca acgatcatcg caaggacgaa ttcctggcga tcctggccca tgaactgcgc
     2701 aatccgctgg cgccgatcag caacgcgcta gagctgctga aacgcgccga cagcagcgat
     2761 ccgatgctgc agaagatcgg tcagatgatg acgcgccagg tgggcaacct gaatcggctg
     2821 gtcgacgatc tgctggaaat ctcgcggatc acgcgcgaca agatcgagct gaagaaggtg
     2881 acggtaacgc tcgacagcat cctgcagacc gccatcgagg ccagtcagcc gctgctcgac
     2941 actcaccggc atcagctcca tgtcagcttg ccgagcggcc tgccgctgct gctggccgat
     3001 ccgctgcgtc tgtcgcaggt gttcgccaac ctgctcaaca acgccgcgaa gttcaccgag
     3061 cccggcgggc agatctggct gagcgtccag caggagccga aagcgctgag catttcggta
     3121 cgcgacaacg gcatcggcat ccggccggac atgcaggcgc gcatcttcga actgttcgcc
     3181 caggcggacg aaatcaccag ccgctcgcag ggcggtctcg gcatcggcct gatgctggtc
     3241 cggcgtctgg tcgaactgca cggcggcacc gtcaaggtga tcagcgaagg gccgggccag
     3301 ggcagcgagt tcatcgtgcg cctgccactg accggcaatc tgacgcagac ggtcagcgcg
     3361 ccattggcca agccttcatc gccggccgga ctgggccagc agcggatcct cgtcgtcgac
     3421 gacaacctcg atgccgcgtc gtccctgtgc cagctgctgg aactctgggg tgctgaaacg
     3481 caggtggccg gcagcggtca ggaagcgctc gacatccttg gcgatttccg acccgacgtg
     3541 gcgatcctcg atatcggcat gcagggaatg gacggcctgg aactggccgg gcggatccgg
     3601 gcgcggcccg agttgagcgg cctgttcctg atcgcgctga ccggctgggg acaggaggaa
     3661 gacatccgcc ggaccctgaa atccggcttc gatcgtcacc tggtcaagcc ggtcaacctt
     3721 gaacttctgc agactttgct gcgcgagcac ccgcgtccgc cgtaaggccg tgcggggctt
     3781 cggcgccaga aagcctcagg gcgttcgggc ggcgcgacgg tcgtcgagcc cgagccactt
     3841 cgagatcagc gtatcgacgc tgacctcgcc cggtccggcc atgatcagcc agccgaagat
     3901 caggatgtag atcacttcgt cgagctcgaa gaagctgtcg acatcggtga cgtccttgat
     3961 gacgacgaag gcgatggcga ccaccatgtt gatcaacatc gggatcgata ccaggcgagt
     4021 cagcagcccg agcatgatca ggccgccgcc gaggaactcg gtccaggccg acagtcccgc
     4081 actgaacgct ggaaacggca gaccccagct gacgaagcgc tcggtgaaac catcgaggtt
     4141 gtggagtttt gcccagccgg tctccagcca gaaatatcca aagcccagac gcatggccag
     4201 cggagcaagc cagtccagac gatcggtcag cttgagtaga gtctctgaga tatcggcgac
     4261 gaaagtacgc atggtcttgt ccagtgggct tgcttgagtg cttgcatcct gggcgcgtca
     4321 ctgccagccc gctatgtcag ggcgtccgag gtttgcggcc gatgcgcctt ctcaatgcgc
     4381 cagctttcgc agaggcagca aatcggatca gggacgagac gacatgaatg cggaacgcta
     4441 ggccgcagtt cgtgcagcga cgggccggca cgatactccg gcatcagtga ttcaccgaca
     4501 gttcgaagtg cagcagaaca gtctctcgag ttccggcgtc tggaatacga aaggctacgt
     4561 atagagatgc gtcccgtcag ctacatccac catctggtca ccctctggtg agcgccgatc
     4621 gggagcgtcg cagttcattc cttaacaaat ccagcaactc tttcgaggag atacaccatg
     4681 aacaccgtca agatgaccag catcgctctc gccaccgccg ccgccggcct gttcagcacc
     4741 gtcgccatca atgtcgcgta tgccgctgac gccgctggcg tgaagtgcga acacgcctcg
     4801 tcctgcaagg gtcagggcgc ctgcaagcag gcctccaatt cctgcaaggg ccagaacgcc
     4861 tgcaagggcc agggcttcac cgaagtgaag agcgccgccg actgcacgaa ggcgcaggct
     4921 gacgccaaga agagctaaaa acgctcttgt gatccgcggc tcggccaagg gccgggctgc
     4981 ggatctttgg attcctgctc atggcgacaa acgcatcaac gactccattg gcgccgctcg
     5041 gcttcgggct gggtttgcgc gtccagcatt acgaagaaat tctcgagagt gatccggcca
     5101 tcgactggct cgagattctt tccgagaact atctgattcc tggcgggcga ccgttgcact
     5161 atctcgcccg ctttcgtgag cgctatccac tggtcatgca tggcgtttcc ttgtcgatcg
     5221 ggagcaccga tccgctcgat cgcagctatc tgaaacagct gaaggcactg gccgatcttg
     5281 tccagccggc gtggatctcc gatcacctgt gctggaccgg tgttgcgggc aacaatctgc
     5341 atgacttgat gccgctgccc tatacggaag aagcgatcaa gcacgtcgcc gatcgcgtgc
     5401 agcaagtgca ggacgcactg ggccgccgca tcctgctgga gaacgtttcc agctacgtca
     5461 cctacagcca ttcgacgatg ccggaatggg agtttctcac cgccgttgcc gaagcggccg
     5521 acagtctgat cctgctcgac atcaacaaca tctatgtcag tggacacaac catggcttcg
     5581 atccccgacg ctatctggat agcgtgccgc cggaccgggt ccagcaattc catctggccg
     5641 gccacgacta tcagggcgcg ttgatcatcg atacccacga tgcgcccgtg ccggagccgg
     5701 tctgggatct gtacgcgcac gcggtccgcc gtttcggcgc cgtgtcgacg atgatcgaac
     5761 gcgacgacaa gatccctccg ctggccgaat tgctcgccga actcgaccgg gcccgcgaga
     5821 tcgcgcagcc gatcctgaaa gtggcatgag cgggcttgcg caactgcaac acgatttcag
     5881 cgcttacctg ctgcgcgacg atgccagcat ctgcagcctg atcgtcggcg atcgaacggc
     5941 agcgctggag cagcgcgtca acgtctatcg agatggctat cgactgcgcc tgatcgaagt
     6001 gctcaccggc gattttccgg ggctgctgca tctgctcggc gctgccgatt tcgatgcgct
     6061 gtgccgcgac tacatcgatg cgcatccctc tacccacttc aatatccgct ggttcggcgg
     6121 ccgcctgcct gattttctgt ccggcagtcc atgcgggtcg caacgcccgg cggttgtgga
     6181 aatggcggtg ctcgaatgga cgctgaccct ggccttcgat gcggtcgacg aagtcagcgt
     6241 gaccatggcc gacgccgcag cgctgacggc ggaacaatgg ccgggcatga agctgcgcat
     6301 ggcggcagcg gtccagcggc ggcagttcgt cgccaacgtc ggcgccattc gccgggcgat
     6361 cgatcgggaa gagacgccgc ctgccgtcga gactttcgac gcccatcggc aatgggtggt
     6421 ctggcggctg gaccggggtg tctaccaacg ccagatggat gccgacgagg cagcggcttt
     6481 cgatggcgcg gcggcaggcg ccagctttgc cgagatttgc gccatcctct gcgaatggca
     6541 cgccgaggag cgcgtggcga tccaggctgc gggcttcctc aagctgtgga tcgagcagca
     6601 gtggatcgcc gaactgatcg ttgatctgat caccgatcac gatgcgcgct gatcgccgcg
     6661 gcacctgggg tgcagcgctg atgatcgtcg cgggcttgtt cggtttaccc gcgcacgctg
     6721 ccggcgacgg cattccgtgg cgcaactggt cggacgatct gttcgcccag tcgcagcgcg
     6781 agcacaagct ggtgctgctc gatctcgaag ccgtctggtg ccactggtgc catgtgatgg
     6841 accagcagac ttatcgggac gccgcggtca tcaagctgct gcgcgagcgc tacatcacgg
     6901 tcaaggtcga tcaggattcg cggccggacc tgtccaatcg ctacgaggat tacggctggc
     6961 cggcgacgat catctacgcg ccggatggcc gcgaactggt caagcgctcc ggctatatcc
     7021 cgcccgcggg catggtgtcg ctattgcagg cggtgatcga cgatccgacg ccggggccat
     7081 cgatcacgcc cgaggtgaag cccgatttca gcgccgccgt gatcgcgtcg tcgctgcgcg
     7141 gcacgctcga gaagctggtc gtcgagcaat acgatgccga gcacggcggc tggggtttct
     7201 cgcagaaatt tctcgatgcc gactcggtcg agtattgcct gcagcagtct cgccgcggcg
     7261 atgccgatgc cacccggatg gcgcggcaga ctctggatgc gcaacggaag ctgctcgatc
     7321 cggtctgggg cggcgtctat caatactcga ccggcggtga ctggctgacg ccgcacttcg
     7381 aaaagatcat gtcgatgcag gccaataacc tgcgcatcta cgcgctggcc tgggcacagt
     7441 ttcacgatcc tgccgatctg aaggcggccc aggccattcg cgactatctc gcccgcttcc
     7501 tgacccgggc cgatggcgcc ttcctgacca gccaggatgc cgatgtcgtg cccggcgagc
     7561 atgcggccga ctacttcgca ctggccgatg ccgcgcggcg cgcccgtggc gttcccgccg
     7621 tcgacagcca cgtttacgcc cgcgagaacg gctgggcgat cgaggcgctg gcaatgctcc
     7681 acgccgccag cggcgagcca ggcgatctgc aggcggcgat caaggcggca ggcgttatcg
     7741 tcgagcaacg cagcctgccc ggcggtggct tccgccatga ccagcacgat cccgcaggcc
     7801 cttatctcgg cgacacgctg gcgatgggcc aggcctttct ggcgctctac tcggcgagcg
     7861 gcgatcgccg ctggctggca cgcgcgcagt cggccgcgca gttcatcgac gctcatttcg
     7921 ccggccaccg ccaacccggt tatcgcactg ccgccagtcg caagggcgcc gcgccagccc
     7981 agccgctgcg cgacgagaat gtccgcatgg cccgtttcgc caatcggctg ttccgctaca
     8041 ccggcgatgc ccggtatcag cagtcggcac agcgcgcgat gcgtttcatc gcggcgccgg
     8101 agatcgcgcg gcgcttcccg gcagcaggcg ccttgctggc cagcgacgaa ctgtcccgcg
     8161 agcctctgca cttcaccgtg gtcggcaaca aggatgacgc ggtggccgct gcgctgttcg
     8221 ccactgccgc cgcctttcca tcggcctata cgcgtaccga atggtgggat cgtcgggaag
     8281 gctcgctggc caacagcgat gtccagtacc ccaggtttcc gaaggccgcg gcctacatct
     8341 gcaccgagcg cagctgctcg ctgccgatct tcgagccccc ggcattttcg atacgtctgg
     8401 cgacgctggc gcacgcgccc tgaacgccag ccttcgatcg gccctggctt ggtgacaaga
     8461 tcgcgatctc tgaaccttga agcggtgaga tcagcatgtt tcgagtcggc atcgacctcg
     8521 gcggcaccaa gatcgaaggc atcgtgctgc gcggtgcggc cgaggtcgtc gcccggcagc
     8581 ggatcgcgac gccgggtggc gattacgcgg cgacggtcgc ggctgttgcg gcattggttt
     8641 ccgcgctcga acgcgaagtc ggggtgcacg agttgccggt cggcatcggt catccgggcg
     8701 cgatctcgcc gttcaccggg ctgatcaaga acgccaattc cacctgcctc aacgatcggc
     8761 cgctgaaggc cgatctcgaa gccgcgctcg gccgcgaagc gcggatggct aacgatgccg
     8821 actgcctggc cttgagcgaa tcgcaggccg atggtgccgc ggccggcgcg gcttgcgtgt
     8881 tcgcggtgat cctcggcacc ggcgtcggcg gcggcatcgt catcgatggc aagctccgcg
     8941 ccggcccgaa tgcgatcgcc ggtgaatggg gccacaaccc gctgccctgg ccgcgtgcgg
     9001 actggcatga agtgccgggc ccgctgggct gggatggccg ccacggatcg atcgaggact
     9061 ggtgcagcgg cgtggcgctg gcgcgcgatc atctcgaggt cagcggcgag aatctgcgtg
     9121 gcgaggaagt cgtcgcgcgt gccgaagcag gcaatgccac tggtattgcg accctcgccc
     9181 gttacgagga tcgtctggcc cgcgcattgg ccagcgtcat caacctgctg gacccggacg
     9241 tgatcgtgct cggtggcggc ttgtcgagag tcgcgcggct gtaccagacc gtgccgcagc
     9301 tatggcgcgc ctgggtgttc agcgatcagg tggcgactcg attgttgccg gccacgcacg
     9361 gcgacagcag cggcgtgcgc ggtgcggcct ggttatggcc gctggccgag ccggatcaga
     9421 cgcgcaatcc gcgcacgtag tcgcccatct cgcggatcgc ctgatcggct tccggcatcc
     9481 agccggccat cgcctgccag acgtgccaga gcttcggcct tacgctgagc agcacctgca
     9541 cgccggcctt gcgggcggcg gcggtcaggc gggtggaatc gtcgagcagc agttcgtcgt
     9601 cgccgacctg gatcagcatc ggcggcaagc cggccagatc ggcgaacagt ggcgacagca
     9661 gcggatcggc gagcttgcgg ccggcggcaa aggtttcggc cgccttgctg atgcccagca
     9721 ccgtgaggat gcggtcgcgc tcggcgcgtg agcccatcga tttgccgctg gagctcatgt
     9781 cggtccatgg cgacagcagc accagcccgg ccggcagcgc catgccggcg tcgcgcaggg
     9841 cgatggcggt gaccagcgcc agattgccgc cggccgaatc accggcgatg acgatgcgct
     9901 cggccgggat gccttcggcg agcagttcct gatagccggc cacggcgtct tcgagcgcag
     9961 ccgggtaggg atgttccggc gccaggcggt aatcgatggc caccacttcg cagccggccg
    10021 ccttggcgaa atgcgcgagc aggccgcgat gagtgcgcgt cgaaccaccg aggtaggcgc
    10081 cgccatgcag gtagtagatg acctgatcgc cggagtcgcc gctcggcgtc agacggtcgg
    10141 ccgggcggcc ggcgagggtc gtcgcttcga tgcgagtgcc gcgcggcaca tgggtgatca
    10201 acctggcgat gcgctccaac tgcggccgca tctcatgggc aggcttggcc agcaccggct
    10261 gcagcaggaa ctgggaaacg gggccgaaca ggcgggcgcg gagactcaag cttgaggtca
    10321 tcgggtacgg aagacggtgg cgccgggcgg gtgccgggcg gcgaagggta gccgatcgat
    10381 gtgaccgatg gacatgggtg cgctggttct cgaaaccgtc cgcaggaacc gccgcgcaac
    10441 ggaaatgtcc catccgggcc gttatgatgg ctgacgctgc tgcctgtggt tccctcgggt
    10501 cagcactggt tcactacccg gaatgccccc tatgtcgttt tcccgcctgt ctctgcccag
    10561 cctgcgccat ctgctgcgcg ccgctctgat cgttgccgcc ggtgccgcga tcgtcggctg
    10621 caaggaaggc cgcgatgcct atgcgatcac cgatagcggc tcgctgatca agttccagac
    10681 cgacaagccg gaatcgctcg acaacacgat gacgatcacg ggcctcgccg atggcgaatc
    10741 gatcctgcag atcgatttcc gagccgagac ggaagtgctg tatggcctga ccagcaacaa
    10801 ccggatcgcc accatcgaca cgggcactgg cgccgcgacc ctggtcagc
//
