LOCUS       c00006_NZ_ATVI..       10891 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_ATVI01000006.1 Nevskia ramosa DSM 11499
            G513DRAFT_scaffold00002.2_C, whole genome shotgun sequence.
ACCESSION   NZ_ATVI01000006
VERSION     NZ_ATVI01000006
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 15:04:23
            Original ID  :: NZ_ATVI01000006.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 779897
            Orig. end    :: 790788
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10891
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[784897:785788](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5891)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10891
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10891
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(324..1940)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1190:GTP-binding protein LepA (Score: 103.5; E-value:
                     2.1e-31)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg6_712"
                     /transl_table=11
                     /translation="MTAVSPLAEAAALRRTFAIISHPDAGKTTLTEKLLLFGGAIQLAG
                     TVKGRKASRHATSDWMALEQQRGISITTSVMQFPYNGKIVNLLDTPGHEDFSEDTYRTL
                     TAVDSALMVIDAAKGVEPRTIKLMEVCRLRDTPIITFINKFDRFGRPPLELLDEVEKVL
                     GLACTPITWPLGMGTEFEGVYHLLEDRFYLYSGDKHKVSDIETVDGLHAPGLAERFGPV
                     YKTLLDEIELLQMAGTAFNIDDYRAAKLTPVFCGSAINNFGVRELLNGFVDWAPGPQPR
                     KATFNAIEHDIYPEHKKFSGFVFKIQANMDPKHRDRVAFLRVCSGTYKKGMSLHSVRLG
                     GPVRINSALTFMAADREAVEEAFPGDIIGLHNHGTIAIGDSFTEGEALNFTGIPNFAPD
                     LFRRVILKDPLKSKQLNKGLDQLCEEGATQVYRPITNNDVILGAVGVLQFEVVQYRLRD
                     EYSVESIFEAATVSTARWVSCDDPKKLKEFRDKNELRLAIDHAGYLVYLASSNVNLQMT
                     KERFPDIRFLDTREQGAAVER"
     aSDomain        complement(348..1919)
                     /aSDomain="TIGR00503"
                     /aSTool="tigrfam"
                     /description="prfC: peptide chain release factor 3"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg6_712_0001"
                     /evalue="2.80E-241"
                     /identifier="TIGR00503"
                     /label="ctg6_712"
                     /locus_tag="ctg6_712"
                     /protein_end="531"
                     /protein_start="7"
                     /score="799.5"
                     /tool="antismash"
                     /translation="AEAAALRRTFAIISHPDAGKTTLTEKLLLFGGAIQLAGTVKGRKA
                     SRHATSDWMALEQQRGISITTSVMQFPYNGKIVNLLDTPGHEDFSEDTYRTLTAVDSAL
                     MVIDAAKGVEPRTIKLMEVCRLRDTPIITFINKFDRFGRPPLELLDEVEKVLGLACTPI
                     TWPLGMGTEFEGVYHLLEDRFYLYSGDKHKVSDIETVDGLHAPGLAERFGPVYKTLLDE
                     IELLQMAGTAFNIDDYRAAKLTPVFCGSAINNFGVRELLNGFVDWAPGPQPRKATFNAI
                     EHDIYPEHKKFSGFVFKIQANMDPKHRDRVAFLRVCSGTYKKGMSLHSVRLGGPVRINS
                     ALTFMAADREAVEEAFPGDIIGLHNHGTIAIGDSFTEGEALNFTGIPNFAPDLFRRVIL
                     KDPLKSKQLNKGLDQLCEEGATQVYRPITNNDVILGAVGVLQFEVVQYRLRDEYSVESI
                     FEAATVSTARWVSCDDPKKLKEFRDKNELRLAIDHAGYLVYLASSNVNLQMTKERFPDI
                     RFLDTRE"
     PFAM_domain     complement(390..773)
                     /aSDomain="RF3_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF16658.7"
                     /description="Class II release factor RF3, C-terminal
                     domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg6_712_0003"
                     /evalue="1.00E-45"
                     /label="ctg6_712"
                     /locus_tag="ctg6_712"
                     /protein_end="517"
                     /protein_start="389"
                     /score="154.8"
                     /tool="antismash"
                     /translation="FTGIPNFAPDLFRRVILKDPLKSKQLNKGLDQLCEEGATQVYRPI
                     TNNDVILGAVGVLQFEVVQYRLRDEYSVESIFEAATVSTARWVSCDDPKKLKEFRDKNE
                     LRLAIDHAGYLVYLASSNVNLQMT"
     PFAM_domain     complement(795..992)
                     /aSDomain="GTP_EFTU_D2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03144.27"
                     /description="Elongation factor Tu domain 2"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg6_712_0002"
                     /evalue="2.20E-08"
                     /label="ctg6_712"
                     /locus_tag="ctg6_712"
                     /protein_end="382"
                     /protein_start="316"
                     /score="34.5"
                     /tool="antismash"
                     /translation="RVAFLRVCSGTYKKGMSLHSVRLGGPVRINSALTFMAADREAVEE
                     AFPGDIIGLHNHGTIAIGDSF"
     PFAM_domain     complement(1113..1898)
                     /aSDomain="GTP_EFTU"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00009.29"
                     /description="Elongation factor Tu GTP binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg6_712_0001"
                     /evalue="4.10E-48"
                     /label="ctg6_712"
                     /locus_tag="ctg6_712"
                     /protein_end="276"
                     /protein_start="14"
                     /score="163.6"
                     /tool="antismash"
                     /translation="RTFAIISHPDAGKTTLTEKLLLFGGAIQLAGTVKGRKASRHATSD
                     WMALEQQRGISITTSVMQFPYNGKIVNLLDTPGHEDFSEDTYRTLTAVDSALMVIDAAK
                     GVEPRTIKLMEVCRLRDTPIITFINKFDRFGRPPLELLDEVEKVLGLACTPITWPLGMG
                     TEFEGVYHLLEDRFYLYSGDKHKVSDIETVDGLHAPGLAERFGPVYKTLLDEIELLQMA
                     GTAFNIDDYRAAKLTPVFCGSAINNFGVRELLNGFVDWAP"
     aSDomain        complement(1494..1889)
                     /aSDomain="TIGR00231"
                     /aSTool="tigrfam"
                     /description="small_GTP: small GTP-binding protein domain"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg6_712_0002"
                     /evalue="6.00E-19"
                     /identifier="TIGR00231"
                     /label="ctg6_712"
                     /locus_tag="ctg6_712"
                     /protein_end="149"
                     /protein_start="17"
                     /score="66.4"
                     /tool="antismash"
                     /translation="AIISHPDAGKTTLTEKLLLFGGAIQLAGTVKGRKASRHATSDWMA
                     LEQQRGISITTSVMQFPYNGKIVNLLDTPGHEDFSEDTYRTLTAVDSALMVIDAAKGVE
                     PRTIKLMEVCRLRDTPIITFINKFDRFG"
     CDS             complement(2028..3200)
                     /locus_tag="ctg6_713"
                     /transl_table=11
                     /translation="MVLLPVVLVVGGCASQSTELPGLIDPGRYQLALNTDNPLQRGSLD
                     RNSLLDGALRFAAPSSLLDYDARYSLLPSLPPTDVGVGIDAPGSEVALMPSQLLGNESL
                     QQNLKMRVPFLFEQPLMITAEERTRGLLTPETLATSRSAQVKWAPAPVALGLRWTPADA
                     AVLALPFSCQLSGTLELPGTRLTGRDDDGLKLQGQGCRASAPDRGLPDVDVGRYSATWQ
                     WQRKRSNSSVHLLVLEAADRLNADASPQTPGYEFGVSRSQSIGEVTAGSAVALRHASSP
                     GDARAPFDWSGRASVSRQFTDVLLSASLQREADPLWFLPNETARIGLSTNSVELGVGFD
                     RWIARQLSTKHVGLGLVGRWTEMPNLNQRSSQAVDQTYDYQVLWNLTLTP"
     CDS             complement(3440..4219)
                     /locus_tag="ctg6_714"
                     /transl_table=11
                     /translation="MSSPKPAYRSLFLSHGAPSLAISQHTANAFLRTLGKTLTKPKAAI
                     VVSPHWMTRGFPVKQAARYQAWHDFGGFPAELYQLQYSPAGDAALAERVQQAIRKAGLP
                     TATDSNPQIDHGVWVPLMLMWPEADVPIVQVSTSNGDAAAHWALGEALRLLLDDGDVLL
                     IGSGSLVHNLREIGPEFSPATDWAMAFDHWMSDKLLTADRAALLDYRAQAPSAVRAHPT
                     DDHLMPLFTAAAAGNAATKLHESYAFGGLSMSAYGFA"
     PFAM_domain     complement(3446..4189)
                     /aSDomain="LigB"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02900.20"
                     /description="Catalytic LigB subunit of aromatic
                     ring-opening dioxygenase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg6_714_0004"
                     /evalue="3.90E-46"
                     /label="ctg6_714"
                     /locus_tag="ctg6_714"
                     /protein_end="258"
                     /protein_start="10"
                     /score="157.4"
                     /tool="antismash"
                     /translation="LFLSHGAPSLAISQHTANAFLRTLGKTLTKPKAAIVVSPHWMTRG
                     FPVKQAARYQAWHDFGGFPAELYQLQYSPAGDAALAERVQQAIRKAGLPTATDSNPQID
                     HGVWVPLMLMWPEADVPIVQVSTSNGDAAAHWALGEALRLLLDDGDVLLIGSGSLVHNL
                     REIGPEFSPATDWAMAFDHWMSDKLLTADRAALLDYRAQAPSAVRAHPTDDHLMPLFTA
                     AAAGNAATKLHESYAFGGLSMSAYGF"
     CDS             complement(4235..5035)
                     /locus_tag="ctg6_715"
                     /transl_table=11
                     /translation="MHQLRRRLRVAEDDLQTQQARFAAHLRDPDTNPPPDDVAPERMAI
                     YRLLFFNNIESLLAKAFPVLRRILANEHWLALVRDFYARHPTRTPLFHKLAEEFVDWLA
                     DGRGEHPGDPPFLAQLAHYEWVELALSTAEDPLPAALLVNPNGDLLNAPPVIAPLCWTL
                     AYDWPVQRIGPDFQPTIASGVQTFLLVHRNRSDEVKFVEINAVTARLLTLAEEQPEASG
                     IELLEQIADELQHDDVDAVVAGGAEILESLRERGILLGTRRRSS"
     PFAM_domain     complement(4727..4984)
                     /aSDomain="DUF2063"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09836.11"
                     /description="Putative DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg6_715_0005"
                     /evalue="2.30E-26"
                     /label="ctg6_715"
                     /locus_tag="ctg6_715"
                     /protein_end="103"
                     /protein_start="17"
                     /score="91.9"
                     /tool="antismash"
                     /translation="QQARFAAHLRDPDTNPPPDDVAPERMAIYRLLFFNNIESLLAKAF
                     PVLRRILANEHWLALVRDFYARHPTRTPLFHKLAEEFVDWL"
     CDS             complement(5001..5891)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg6_716"
                     /sec_met_domain="DUF692 (E-value: 6.8e-113, bitscore:
                     372.1, seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPNPATTVAAPRLAQPAAVRGAGLGLRRALLEPLAELKAGAIDFL
                     EIAPENWMQLGGRFGRQFRALTERYPFAAHGLSLSLGGPAPLDESFVLALKRFLDEHGI
                     ADYSEHLSYCSDARGQLYDLMPIPHTEEAVAHVAARIRRVQDLLERRIAVENVSTYAAP
                     GQRISELAFINAVIAEADCDLLLDVNNIHVNSINHGYDASAFLDGLPLSRVRYVHIAGH
                     HAEAHDLCIDTHGADVIDPVWALLAQACAKLGPLPTLLERDFNLPPLATLLVEINQIRA
                     VQARHAPAQAATARG"
     PFAM_domain     complement(5043..5831)
                     /aSDomain="DUF692"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05114.15"
                     /description="Protein of unknown function (DUF692)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg6_716_0006"
                     /evalue="1.10E-101"
                     /label="ctg6_716"
                     /locus_tag="ctg6_716"
                     /protein_end="283"
                     /protein_start="20"
                     /score="339.6"
                     /tool="antismash"
                     /translation="GAGLGLRRALLEPLAELKAGAIDFLEIAPENWMQLGGRFGRQFRA
                     LTERYPFAAHGLSLSLGGPAPLDESFVLALKRFLDEHGIADYSEHLSYCSDARGQLYDL
                     MPIPHTEEAVAHVAARIRRVQDLLERRIAVENVSTYAAPGQRISELAFINAVIAEADCD
                     LLLDVNNIHVNSINHGYDASAFLDGLPLSRVRYVHIAGHHAEAHDLCIDTHGADVIDPV
                     WALLAQACAKLGPLPTLLERDFNLPPLATLLVEINQIRAVQ"
     CDS             complement(5903..6208)
                     /locus_tag="ctg6_717"
                     /transl_table=11
                     /translation="MSIINKRKPLAVALGVAFAIGGAAQASSLFVASDLAAGYMVASIG
                     DKAGEHSCGEGGCGGDMKATPAAATKDAAQKNSAEAKAAADKAAADKAKASEAKPK"
     CDS             6433..7353
                     /gene_functions="regulatory (smcogs) SMCOG1287:AraC family
                     transcriptional regulator (Score: 240.2; E-value: 4.6e-73)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg6_718"
                     /transl_table=11
                     /translation="MLDRSAEAAFAAVLGAHQLRAYISDNPHYCGSFVEAERALPHGMF
                     HLIDEGECMVDFARTGDSLLLHSGDLVMFPHGAAHTLRSPPDTDAGPAANRFTSILCGE
                     FEFATGSRNPILDALPDWIVVREADSQQQFRHLARLMAHEARQESFGRQLVLDKLADAL
                     FVMALRQHIASSNERRGLIAALIDPRMARVLEAMHAAPGRAWTVAMLAELAHQSRTAFA
                     QHFNEVLGVSPYQYLTEWRMAEALRLLADPKSSAATIAEKLGYQTEAAFRRAFKKIHGY
                     GPGRTRRAARSAQIDAVPSAAAANR"
     PFAM_domain     6463..6951
                     /aSDomain="Cupin_6"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12852.9"
                     /description="Cupin"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg6_718_0007"
                     /evalue="4.30E-32"
                     /label="ctg6_718"
                     /locus_tag="ctg6_718"
                     /protein_end="173"
                     /protein_start="10"
                     /score="111.4"
                     /tool="antismash"
                     /translation="AAVLGAHQLRAYISDNPHYCGSFVEAERALPHGMFHLIDEGECMV
                     DFARTGDSLLLHSGDLVMFPHGAAHTLRSPPDTDAGPAANRFTSILCGEFEFATGSRNP
                     ILDALPDWIVVREADSQQQFRHLARLMAHEARQESFGRQLVLDKLADALFVMALRQHIA
                     "
     PFAM_domain     7060..7296
                     /aSDomain="HTH_18"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12833.9"
                     /description="Helix-turn-helix domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg6_718_0008"
                     /evalue="7.30E-20"
                     /label="ctg6_718"
                     /locus_tag="ctg6_718"
                     /protein_end="288"
                     /protein_start="209"
                     /score="71.1"
                     /tool="antismash"
                     /translation="LAELAHQSRTAFAQHFNEVLGVSPYQYLTEWRMAEALRLLADPKS
                     SAATIAEKLGYQTEAAFRRAFKKIHGYGPGRTRR"
     CDS             7670..8824
                     /gene_functions="other (smcogs) SMCOG1077:phage integrase
                     family protein (Score: 134.9; E-value: 8.1e-41)"
                     /gene_kind="other"
                     /locus_tag="ctg6_719"
                     /transl_table=11
                     /translation="VATIVKVPVKPKMTAPLSEGASRRQEFRYKALVRLTGWPTTSKTF
                     RLKKDAEDWARRTEDEMIRGVFIQRAPAERMTLSTALDRYAREVTPTKKASSQATELRR
                     IDSLKRLLGGYSMAALSSDLVADFRDRRLAGDVDPRTGLRRPRAANTVRLELALLSHVF
                     TVAIKEWRLGLVYNPVQNIRKPARGPGRNRRLSPDEEAKLLARIDGHSNPMLRWIVRIA
                     LETGMRSSEITSLRRSQVDIQRRIVRLLETKNTSPRTVPLTMAAAALFEEALHHPVRPI
                     DTDLIFFGEPGRDGIRRPYEFNKVWTGVKAEVGIKDFRFHDLRHEAVSRFVEAGLGDQE
                     VAAISGHKSMQMLKRYTHLRAEDLVMRLEELTTIRRDRVKSRPI"
     PFAM_domain     8249..8752
                     /aSDomain="Phage_integrase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00589.24"
                     /description="Phage integrase family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg6_719_0009"
                     /evalue="3.30E-29"
                     /label="ctg6_719"
                     /locus_tag="ctg6_719"
                     /protein_end="361"
                     /protein_start="193"
                     /score="102.0"
                     /tool="antismash"
                     /translation="RLSPDEEAKLLARIDGHSNPMLRWIVRIALETGMRSSEITSLRRS
                     QVDIQRRIVRLLETKNTSPRTVPLTMAAAALFEEALHHPVRPIDTDLIFFGEPGRDGIR
                     RPYEFNKVWTGVKAEVGIKDFRFHDLRHEAVSRFVEAGLGDQEVAAISGHKSMQMLKRY
                     THLRA"
     CDS             9203..9658
                     /locus_tag="ctg6_720"
                     /transl_table=11
                     /translation="MQKETIEVSVGHHEKLLEIGNDLELLYYALGPIWTDAPLLWKARH
                     EPGVSACKAVDFLLDRIEHRMHDSQNVRALLAGCCGAMDTPVQLTHLWQLSEDSKPAAH
                     AVLEWVGSVAGLQLDDFQDGGARFLRLVLRKRPQIIARMVVAEGAAC"
     CDS             9652..10188
                     /locus_tag="ctg6_721"
                     /transl_table=11
                     /translation="MLRRVIAGFAVLLVASGCQGQSNQLDCTAGGKPIPHEVLVGNWTW
                     TYELDDGTKQVWLRQFMPDGHVNLFVRGFTKPDAKWPNGLVSTRGTFGRWFISNRTWVV
                     MMDGAYRAADPLGEKFYWVNGNGSQLPDGDARIIGDITPDSINVCFSNGQHYATMQRVD
                     DKFELPEHFPPRSGR"
     CDS             10287..10517
                     /locus_tag="ctg6_722"
                     /transl_table=11
                     /translation="MSTTNRRRDRDEHGRLKRKYRGPNSIMTTPGYWVTLHMNRPRRHL
                     NRHLCHLVTQGLDPAGVVWPLGNHKPHIYFW"
ORIGIN
        1 accctgcagt cgatcgccgc gaagctgtcg cacctgctgc tctacgcgct gatgttcgcg
       61 atgccgctgg tgggctggtc gatgctgtca gccggcggct atccgattcc gatgttcggc
      121 tcggtgcacc tgccagcgat cgtcccgcac gatccggcgc tctacgccgt gctccgctgc
      181 gcccacacct ggctggcctt cctgctgttc gccaccgtgc tgctgcatct cgccgccgcg
      241 ctgttccatg cctgggtgcg gcgtgacggc gtgtttcaga gcatggctgg cggcgactag
      301 aaccttgtcg ccgttgtggc gcttcagcgc tcgacggcgg ccccctgttc ccgcgtatcc
      361 agaaaccgga tatccggaaa ccgttccttg gtcatctgca ggttgacgtt gctgctggcc
      421 aggtagacca gatagccggc gtggtcgatg gccaggcgca gttcgttctt gtcgcggaat
      481 tccttgagct tcttcgggtc gtcgcaggac acccagcgtg ccgtggaaac ggtggccgct
      541 tcgaagatcg attcgacgct gtactcgtcg cgcagccggt actgcaccac ttcgaactgc
      601 agcacgccga cggcgccgag gatcacgtcg ttgttggtga tcgggcgata gacctgggtg
      661 gcgccttctt cgcagagctg atcgaggccc ttgttgagct gcttggattt cagcgggtct
      721 ttcaggatca cgcggcggaa caggtccggt gcgaagttcg ggatgccggt gaagttcagg
      781 gcttcgcctt cggtgaacga atcgccgatg gcgatggtgc cgtggttgtg caggccgatg
      841 atgtcgcccg ggaaggcttc ctcgacggct tcgcgatccg ccgccatgaa ggtcagtgcg
      901 ctgttgatcc gcaccgggcc gccgaggcgc accgagtgca ggctcatgcc tttcttgtag
      961 gtgccggagc agacccgcag gaaggccacg cgatcgcgat gcttcggatc catgttcgcc
     1021 tggatcttga acacgaagcc ggagaacttc ttgtgctcgg gatagatgtc gtgctcgatg
     1081 gcgttgaacg tcgccttgcg tggctgcggg ccgggcgccc agtcgacgaa gccgttgagc
     1141 agttcgcgca cgccgaagtt gttgatcgcc gagccgcaga acaccggcgt cagcttggcg
     1201 gcgcggtagt catcgatgtt gaacgcggtg ccggccatct gcagcagttc gatctcgtcg
     1261 agcaaggtct tgtagaccgg cccgaaacgc tcggcgaggc cgggcgcgtg caggccgtcg
     1321 acggtctcga tgtccgacac cttgtgcttg tcgccgctgt acagatagaa gcggtcttcg
     1381 agcaggtgat agacgccttc gaactcggtg cccatgccca gcggccaggt gatcggcgtg
     1441 caggccaggc caagcacttt ctcgacttcg tcgagcagct ccagcggcgg ccggccgaag
     1501 cgatcgaact tgttgatgaa ggtgatgatc ggcgtgtcgc gcaggcggca gacttccatc
     1561 agcttgatgg tgcgcggctc cacacccttg gcggcgtcga tgaccatcag tgccgagtcg
     1621 accgccgtca gcgtgcggta ggtgtcttcg ctgaagtctt catggcccgg cgtatcgagc
     1681 aggttgacga tcttgccgtt gtacgggaac tgcatcaccg aagtggtgat cgagatgccg
     1741 cgctgctgtt ccagcgccat ccagtccgag gtggcatgac ggctggcctt gcgtcctttc
     1801 acggtgccgg cgagctggat cgcgccgccg aacagcagca gcttttcggt cagcgtggtc
     1861 ttgccggcat cgggatggga aatgatcgcg aaggtgcggc gcagcgcggc ggcttcggcg
     1921 aggggggaga cagcagtcat ggcaacgggc agccggggga agcacgggaa acttgcgggc
     1981 cgcgattgta tcgcagggtc tggggtcggc cgtccagata caaatgctca gggcgtcaac
     2041 gtcaggttcc acagcacctg gtagtcgtag gtctgatcga cggcctgact gcttctctga
     2101 ttgaggttgg gcatttcggt ccagcgcccg accagaccaa gcccgacatg cttcgtcgac
     2161 agctgccggg cgatccagcg atcgaagccc acaccgagtt cgacgctgtt ggtgctgagg
     2221 ccgatgcgtg ccgtctcgtt gggcaggaac cacagcggat cggcttcgcg ctgcagcgag
     2281 gcggagagca acacatccgt gaactgacgg ctgacgctgg cgcggcccga ccagtcgaac
     2341 ggcgctcggg catcgccggg gctgctggca tgccgcaggg caaccgctga acctgcggtc
     2401 acctcgccga tggactgcga gcggctgacg ccgaactcgt agccgggtgt ctgcggggac
     2461 gcgtcggcgt tcagacgatc cgccgcctcc agcaccagca gatgcacgct gctgttcgag
     2521 cgcttgcgct gccattgcca ggtagccgag tagcgaccga catcgacatc gggcaggccg
     2581 cgatccggtg cgctggcccg gcagccctgg ccctgcagct tcaggccgtc gtcgtcgcgg
     2641 ccggtgagcc gcgtgccggg aagctcaagc gtgccgctga gctggcagct gaagggcagt
     2701 gccagcacgg ccgcgtccgc cggcgtccag cgcaggccca gtgccactgg cgctggtgcc
     2761 catttcacct gcgccgagcg actggtcgcc agggtttccg gcgtcagcag tccgcgagtg
     2821 cgctcctcgg ccgtgatcat cagcggctgc tcgaacagga acggcacccg catcttcagg
     2881 ttctgctgga ggctttcgtt gccgagcaac tgcgacggca tgagcgcgac ttcgctgccc
     2941 ggggcgtcga tgccaacgcc gacatcggtt ggcggcagcg acggcagcag cgagtagcgg
     3001 gcgtcgtagt cgagcaggct ggacggtgcc gcgaagcgca gcgcgccatc gagcagcgag
     3061 ttgcgatcga ggctgccgcg ttgcaagggg ttgtcggtgt tcaaggccag ctggtagcgg
     3121 ccgggatcga tcaatcccgg cagttccgtg gactgcgaag cgcagccacc gaccacgagg
     3181 acgacgggca gcagcaccat cggcagcgca cagtttcgta cgctggcgat ccttcgccgg
     3241 cttggcaact tcctgttcac ctcattgcga cccccagcag acgggtaaaa gttccccggc
     3301 tgcctatctt tgcccctgtt gcccagcgct tgttcaggcg ccggctgcgc gtcagcgccg
     3361 ctcggcgcgg cctgtcagta gggttcgcaa agctcgggcc aatcgtcgca aagcgtgccg
     3421 cgaggccaga agttgaggct caggcgaagc cgtaagccga catgctcagg ccgccgaagg
     3481 catagctttc atgcagcttg gtggcggcat tgccggctgc ggctgccgtg aacagcggca
     3541 tcaggtgatc gtcggtgggg tgagcgcgaa cagcggatgg cgcttgcgcg cggtagtcga
     3601 gcagggcggc gcgatcggcc gtcagcagct tgtcgctcat ccagtgatcg aaggccatcg
     3661 cccagtcggt ggctggcgag aattcggggc cgatctcgcg caggttgtgg accaggctgc
     3721 cgctgccgat cagcagcaca tcgccgtcat caagcagcag ccgcagcgcc tcgcccagcg
     3781 cccagtgcgc cgcggcatcg ccgttggacg tgctgacctg gacgatcggc acatcggcct
     3841 ccggccacat cagcatcagc ggcacccaga cgccgtgatc gatctgcgga ttgctgtcgg
     3901 tcgcggtcgg caggccggcc ttgcggatcg cctgctgcac gcgctcggcc agcgcagcat
     3961 cgccggccgg cgagtactgc aactgataca gctcggccgg aaaacccccg aagtcatgcc
     4021 aggcctgata gcgcgccgcc tgcttcaccg ggaagccgcg ggtcatccag tgcggcgaca
     4081 ccacgatcgc cgccttcggc ttggtcaagg tcttgccgag cgtgcgcagg aaggcattgg
     4141 cggtgtgctg gctgatcgcc aggcttggcg cgccatggct gaggaacagg ctgcggtaag
     4201 cgggcttggg gctggacatg gcggcttcag gcattcagga cgagcgacgt cgggtaccga
     4261 gcaagatgcc gcgttcgcgc aggctttcaa ggatctcagc acccccagcg accacagcgt
     4321 cgacatcgtc atgctgcaat tcgtcggcga tctgttcgag cagctcgatg cccgaggcct
     4381 ccggctgctc ttccgccagg gtcagcagcc gcgcggtgac ggcgttgatc tcgacgaatt
     4441 tcacctcgtc actgcggttg cggtggacga gcaggaaggt ctgcacaccg ctggcaatgg
     4501 tgggctggaa atccgggccg atgcgttgca ctggccagtc ataggccaag gtccagcaca
     4561 gcggggcaat caccggcggt gcgttcagca gatcgccgtt cggattgacc agcaaggcgg
     4621 cgggcagcgg gtcttcggcc gtgctcagcg ccagttccac ccactcgtag tgcgcgagct
     4681 gcgccaggaa cggcggatcg cccggatgct cgccacggcc atcggcaagc cagtcgacga
     4741 actcctcggc cagcttgtgg aacagcggcg tacgcgtcgg gtgccgggcg tagaaatccc
     4801 gcacaagagc cagccagtgc tcattggcca gaatccggcg cagcactgga aaagccttgg
     4861 cgagcaggct ttcgatgttg ttgaagaaca gcaggcgata gatcgccatg cgttccggcg
     4921 cgacatcatc cggcggcgga ttggtgtccg ggtcacgcag atgggcggcg aagcgcgcct
     4981 gctgcgtctg caggtcatcc tcagccacgc gcagtcgccg cctgagctgg tgcatggcgc
     5041 gcctgcacgg cgcgaatctg gttgatctcg actagcaagg tcgccagcgg cggcagattg
     5101 aaatcccgtt ccagcagagt cggcagcggg ccgagcttcg cgcaggcttg cgcgagcagt
     5161 gcccagaccg gatcgatcac gtcggcaccg tgggtgtcga tgcacagatc gtgcgcttcg
     5221 gcgtgatggc cggcgatgtg gacgtagcgc acgcgcgaca ggggcaggcc gtcgaggaag
     5281 gcgctggcgt cgtagccgtg attgatgctg ttgacgtgga tgttgttgac gtcgagcagc
     5341 agatcgcagt ccgcctcggc gatcaccgcg ttgatgaacg ccagctcgct gatccgctgg
     5401 ccgggtgcgg cataagtgct gacgttctcg accgcgatgc gtcgctcgag cagatcctgc
     5461 acgcggcgga tgcgggccgc gacgtgcgcc acggcctcct cggtatgcgg gatcggcatc
     5521 aggtcgtaca gctggccgcg ggcatcgctg cagtagctca gatgctcgct gtaatcggcg
     5581 atgccgtgct cgtcgagaaa gcgcttcagc gccagcacga agctttcatc gagcggtgcc
     5641 ggcccgccca gcgacaggct caggccgtgg gcggcgaacg gataacgctc ggtcagcgcc
     5701 cggaattgcc ggccgaatcg gccgcccagc tgcatccagt tttccggagc gatctcgaga
     5761 aaatcgatcg cacctgcctt caactccgcg agcggctcca gcagtgctct acgcaggccc
     5821 agcccggcac cgcgcaccgc cgccggctgc gcgagacgcg gcgcggcgac ggtcgtggcc
     5881 gggttcggca tcagcgatcc gcttacttcg gtttggcttc gctggccttg gccttgtcgg
     5941 cagcagcctt gtcagcagcc gccttggctt cggcgctgtt cttctgggcg gcgtccttgg
     6001 tggccgctgc cggcgtggcc ttcatgtcgc cgccgcagcc gccttcgccg caggaatgct
     6061 cgccagcctt gtcaccgatc gaagcgacca tgtagccggc cgccagatcg ctggccacga
     6121 acaacgacga agcctgtgcc gcgccgccga tcgcgaatgc cacgccaagg gccacggcca
     6181 gcggcttgcg cttgttgatg atgctcatct gtctgctcct gtttcgaatg agcccgcgag
     6241 ggctgaaggt ggtatcgaac tgtaccggct cccgctgacc gccggtgtta cggctggcca
     6301 ctcgacgcgc cgggaagtga ccacgaagcg cggccgtccg ttcaaccggc agatcgctgc
     6361 gcagccgatt tcctatactg cccgtgctga cccacgccgc tccggcatcg gcggcgcaag
     6421 agttgtccac ccatgctcga tcgctcggcc gaagccgcgt ttgccgcggt gctcggcgcc
     6481 catcagctgc gcgcctacat cagcgataac ccgcactact gcggcagctt cgtcgaggcc
     6541 gaacgtgcct tgccgcacgg catgttccat ctgatcgacg aaggcgaatg catggtcgac
     6601 ttcgcccgta ccggcgattc actcctgctg cattccggcg atctggtgat gtttccgcat
     6661 ggcgccgcgc ataccctgcg cagcccgccg gataccgatg ccggcccggc tgccaatcgc
     6721 ttcacctcga tcctgtgcgg cgaattcgag ttcgccaccg gcagccgcaa tccgattctc
     6781 gacgcgctgc cagactggat cgtcgtccgt gaagccgaca gccagcagca gttccgccat
     6841 ctggcccggc tgatggccca cgaggcgcgc caggaatcgt tcggccggca gctggtactc
     6901 gacaagctcg ccgacgcctt gttcgtcatg gcgctgcgcc agcacatcgc cagcagcaac
     6961 gaacgccgcg gcctgatcgc cgcgctgatc gacccgcgca tggcccgcgt cctcgaagcc
     7021 atgcacgccg cccccggccg cgcctggacc gtggcgatgc tcgccgaact cgcccatcaa
     7081 tcgcggaccg ccttcgctca acacttcaac gaagtgctgg gtgtgagccc ctaccagtac
     7141 ctcaccgagt ggcgcatggc cgaagcgctg cgcctgctcg ccgatccgaa atcctccgcg
     7201 gcgacgattg ccgaaaagct cggctaccag accgaagccg cgttccgccg cgccttcaag
     7261 aaaatccacg gctacggccc cggccgcacc cgccgcgccg cccgcagcgc ccagatcgac
     7321 gccgtaccga gtgccgcggc cgcgaatcgc tgaaccaagt cgaaaccaca ccggaaaccg
     7381 gcccggacgc tggcacaata ccgccgcgat ccatgcagtc ggcgcaaacg ggcctttagc
     7441 tcaattggtt agagcagggg actcataatc cctaagtcat tgacggcagg cacgcgctcc
     7501 ttcaaatttc cctaagacgg tgaatgtcga taaagggcct ttagctcaat tggttagagc
     7561 agagaactca taattcttag gttgccggtt caagtccggc agggcccacc attcaccgag
     7621 aaactggccg caggtacaaa tctggtacag cggtgcaccg gggattgccg tggcgaccat
     7681 tgtgaaagtg cctgtgaagc cgaagatgac ggcgcctctg tcggagggtg caagccgcag
     7741 gcaggaattc aggtacaagg cgctggtccg cctcaccggc tggccgacga ccagcaagac
     7801 cttccgcctc aagaaggacg ccgaagactg ggcgcggcgg accgaagacg aaatgatccg
     7861 cggcgtcttc atccagcggg ctccggctga gcgtatgacg ctgagcaccg cgctcgatcg
     7921 ctacgctcgg gaagtgaccc ccacgaagaa ggccagctct caggcaaccg agctccgccg
     7981 gatcgattcg ctgaagcgct tgctcggtgg gtattcgatg gccgccctgt cttcggactt
     8041 ggttgccgat tttcgggacc gtcgccttgc cggtgatgtc gatcccagaa ccggcctgcg
     8101 tcggccgagg gcggcgaaca cggtacgttt ggagcttgcg ctactgagtc acgtgttcac
     8161 tgtggcgatc aaggaatggc ggctgggcct cgtgtacaac ccggtccaga acatccggaa
     8221 gccagcccgt gggcccgggc gcaatcgtcg gctttcgcca gatgaggaag caaagttgct
     8281 ggcgcgcatc gacggccaca gcaatccgat gctgcggtgg atcgtccgta tcgccctaga
     8341 gacagggatg cgttcgtcgg agatcacctc gctgcgccgg agccaagtcg acatccagcg
     8401 ccggatcgtt cgattgctgg aaaccaagaa cacctcgccg agaaccgtcc cgctgaccat
     8461 ggccgcggca gcgcttttcg aggaagccct tcatcatcca gttcgcccta tcgacaccga
     8521 tctgatcttc ttcggcgagc cgggccgcga cggaatccgt aggccctacg aattcaacaa
     8581 ggtctggacc ggcgtgaagg cagaggtcgg catcaaggac tttcgcttcc atgacctgcg
     8641 acacgaagcc gtcagccgtt tcgtcgaggc aggccttggc gaccaagagg tcgccgcgat
     8701 cagcggccac aaatcgatgc agatgctcaa gcgttacacc catcttcgag cggaagatct
     8761 cgtgatgcgg ctcgaagagt taacgacgat ccgccgggat cgagtgaaat cgcggccgat
     8821 ctagcggtgg cggctgcggt gtgatgtcgg gttagttctt aagacagctt tcggcgaccg
     8881 cgagcgcgcg atgtatgcgg tagatcggtc aactccgaca gatccggcat tagctccgca
     8941 ggcgggcagc ctagccctgc ggaaattcga aaaagcactt cgagcgtgat gttgtaccgt
     9001 ccacgctcga catggctgta gtaggcccga tcgacgttca ccttctcggc gaagtcgtcc
     9061 tgagacaggc ccagcgcctc ccgtcgagac cggatcgaac gaccaactaa ctctatggag
     9121 ggatgctgtt tgcgcatcct cgccattctc agaatggtgc gatataacac cacttggttt
     9181 agaacaacgg tgtttagcac acatgcaaaa agagacgatc gaagtcagcg tcggccacca
     9241 cgaaaagctt cttgaaatcg gtaatgacct ggagctgctc tattacgccc tcggaccaat
     9301 ctggaccgat gcgccgctcc tatggaaggc gagacacgaa cccggcgtct cggcctgcaa
     9361 ggccgtcgac ttcctgctcg accggatcga gcatcggatg cacgacagcc agaacgtccg
     9421 cgcgctgctc gcagggtgct gcggagcgat ggatactccc gtccagctga cccacctctg
     9481 gcagctcagc gaggacagca agccggctgc ccacgcggtg ctggaatggg tcggcagcgt
     9541 cgcgggcctg cagctcgatg acttccagga cggcggcgcc cgattcctgc gcctcgtact
     9601 tcgcaagcgc ccgcagataa tcgcgagaat ggtcgttgcc gagggcgccg catgctgaga
     9661 cgagtaatcg ccggctttgc tgtcctgctg gttgccagtg gctgccaagg acaatcgaac
     9721 cagctcgact gcacggcagg cggcaaaccg atcccgcatg aagtgctggt cggtaactgg
     9781 acctggacct acgaactaga cgacggcacc aagcaggtat ggcttcgcca attcatgccg
     9841 gacggtcacg tgaacctgtt cgtgcgcggc ttcaccaagc ccgacgcgaa gtggcccaat
     9901 ggccttgtca gcactcgcgg aaccttcggt cgctggttca tcagcaaccg cacctgggtc
     9961 gtcatgatgg acggtgcgta ccgtgccgca gatccgctgg gggagaagtt ctactgggtc
    10021 aacggtaacg gttcgcagct accggatggg gacgcccgga tcatcggcga catcacaccc
    10081 gacagcatca atgtctgctt cagcaatggg cagcactacg ccacgatgca gcgcgtcgac
    10141 gacaagttcg aattacccga acactttccc ccgcgaagtg ggcgatagcc tgacccggcc
    10201 cgccaccgcg agataatccc gccatgaatc acccgagcca gaccaggagg cgggccgtgc
    10261 tttaggacct aacaaggagc taaagcatgt ccacaaccaa tcgccgtcgc gatcgggacg
    10321 agcacggccg cctcaagcgg aagtaccgtg gcccgaacag catcatgacg accccaggct
    10381 actgggtgac gctgcatatg aaccggccgc ggcgtcacct aaatcgccat ctctgccact
    10441 tggtcactca aggactcgat cccgctgggg tcgtctggcc gctcggcaat cacaagccgc
    10501 atatctactt ctggtgactg ttcccgcttg gccagaccgt tgcacatgtg caacggcgtg
    10561 gccaaagctg gcctttgacc gaaccgaagt acgtgatggt cgtggaagtc gggaatggcg
    10621 agatgtccgc tcccatggcg gcgccccaac caatttcgac aaggacacgg ttcgccgatc
    10681 ggtcggcatc cccaccagga tcggttgtca cactttcagt gcgaccggcg acaccgaata
    10741 cctgcgcaac ggcggcaggc cggagatcgc gcagaagatg gtcgccacac tttgagcacc
    10801 gcaacgcacc gaatctgaag tgctctcgat acctcaggcg aaagaggcga accgaccaga
    10861 ggacagtcgc aaccctttta tgttcgggcg c
//
