Select genomic region:
Overview
1.1
1.2
1.3
1.4
1.5
1.6
1.7
1.8

### Identified secondary metabolite regions using strictness 'relaxed'

NC_017168.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1.1 | siderophore,hserlactone | 3 | 22,997 | aerobactin | Other | 66%
Region 1.2 | NRPS | 228,300 | 282,478 | colicin V | RiPP | 1%
Region 1.3 | betalactone | 510,293 | 537,080 | colicin V | RiPP | 1%
Region 1.4 | hserlactone | 2,997,658 | 3,018,302 |
Region 1.5 | siderophore | 3,900,994 | 3,921,313 | putrebactin / avaroferrin | Other | 100%
Region 1.6 | PKS-like | 3,989,676 | 4,030,959 | taxlllaid A | NRP | 15%
Region 1.7 | thiopeptide | 4,079,415 | 4,107,586 |
Region 1.8 | NRPS-like | 4,493,043 | 4,536,456 | colicin V | RiPP | 1%

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1.1 | siderophore,hserlactone | 3 | 22,997 | aerobactin | Other | 66%
Region 1.2 | NRPS | 228,300 | 282,478 | colicin V | RiPP | 1%
Region 1.3 | betalactone | 510,293 | 537,080 | colicin V | RiPP | 1%
Region 1.4 | hserlactone | 2,997,658 | 3,018,302 |
Region 1.5 | siderophore | 3,900,994 | 3,921,313 | putrebactin / avaroferrin | Other | 100%
Region 1.6 | PKS-like | 3,989,676 | 4,030,959 | taxlllaid A | NRP | 15%
Region 1.7 | thiopeptide | 4,079,415 | 4,107,586 |
Region 1.8 | NRPS-like | 4,493,043 | 4,536,456 | colicin V | RiPP | 1%

No secondary metabolite regions were found in these records:
  NC_017169.1
  NC_017170.1

Compact view
NC_017168.1 - Region 1 - hserlactone,siderophore
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3 - 22,997 nt. (total: 22,995 nt) Show pHMM detection rules used
siderophore: IucA_IucC
hserlactone: Autoind_synth

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | siderophore | hserlactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001499.1 |  |  | 0.86 | Other | aerobactin | Pantoea ananatis
BGC0001498.1 |  |  | 0.62 | Other | aerobactin | Xenorhabdus szentirmaii DSM 16338
BGC0001572.1 |  |  | 0.56 | Other | desferrioxamine E | Pantoea agglomerans
BGC0001478.1 |  |  | 0.56 | Other | desferrioxamine E | Streptomyces sp. ID38640
BGC0001713.1 |  |  | 0.54 | Other | ochrobactin | Ochrobactrum anthropi
BGC0000942.1 |  |  | 0.52 | Other | petrobactin | Bacillus anthracis str. Ames
BGC0000941.1 |  |  | 0.49 | Other | desferrioxamin B | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000939.1 |  |  | 0.47 | Other | aerobactin | Grimontia hollisae
BGC0000940.1 |  |  | 0.47 | Other | desferrioxamin B, desferrioxamine E | Streptomyces coelicolor A3(2)
BGC0001453.1 |  |  | 0.47 | Other | desferrioxamine | Streptomyces argillaceus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001499.1 |  | 0.80 | Other | aerobactin | Pantoea ananatis
BGC0001498.1 |  | 0.69 | Other | aerobactin | Xenorhabdus szentirmaii DSM 16338
BGC0001478.1 |  | 0.66 | Other | desferrioxamine E | Streptomyces sp. ID38640
BGC0001572.1 |  | 0.63 | Other | desferrioxamine E | Pantoea agglomerans
BGC0001713.1 |  | 0.62 | Other | ochrobactin | Ochrobactrum anthropi
BGC0000939.1 |  | 0.60 | Other | aerobactin | Grimontia hollisae
BGC0000942.1 |  | 0.59 | Other | petrobactin | Bacillus anthracis str. Ames
BGC0000941.1 |  | 0.56 | Other | desferrioxamin B | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001453.1 |  | 0.56 | Other | desferrioxamine | Streptomyces argillaceus
BGC0000940.1 |  | 0.56 | Other | desferrioxamin B, desferrioxamine E | Streptomyces coelicolor A3(2)

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_017168.1 - Region 2 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 228,300 - 282,478 nt. (total: 54,179 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000427.1 |  | 0.33 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0000375.1 |  | 0.32 | NRP | indigoidine | Streptomyces chromofuscus
BGC0000412.1 |  | 0.32 | NRP | pyochelin | Pseudomonas aeruginosa PAO1
BGC0000900.1 |  | 0.31 | Other | ferrichrome | Aspergillus oryzae
BGC0000876.1 |  | 0.28 | Other | neopolyoxin C | Streptomyces tendae
BGC0000373.1 |  | 0.28 | NRP | holomycin | Streptomyces clavuligerus ATCC 27064
BGC0001479.1 |  | 0.26 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0001718.1 |  | 0.26 | NRP | okaramine D | Aspergillus aculeatus ATCC 16872
BGC0001399.1 |  | 0.25 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0000901.1 |  | 0.25 | Other | ferrichrome | Aspergillus niger

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000427.1 |  | 0.66 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0000375.1 |  | 0.66 | NRP | indigoidine | Streptomyces chromofuscus
BGC0000412.1 |  | 0.66 | NRP | pyochelin | Pseudomonas aeruginosa PAO1
BGC0000900.1 |  | 0.64 | Other | ferrichrome | Aspergillus oryzae
BGC0000876.1 |  | 0.62 | Other | neopolyoxin C | Streptomyces tendae
BGC0000373.1 |  | 0.61 | NRP | holomycin | Streptomyces clavuligerus ATCC 27064
BGC0001479.1 |  | 0.60 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0001718.1 |  | 0.60 | NRP | okaramine D | Aspergillus aculeatus ATCC 16872
BGC0001399.1 |  | 0.59 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0000901.1 |  | 0.59 | Other | ferrichrome | Aspergillus niger

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 4, location 228299 - 282478:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (cys) + (cys) + (Me-cys)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_200: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (229..619): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      gLvFvGGPvK
    Nearest Stachelhaus code:
      ala
    Stachelhaus code match:
      60% (weak)
ctg1_214: cys
  Search NORINE for peptide: strict or relaxed
  AMP-binding (751..1156): cys
  NRPSPredictor2: cys
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      cys
    Small clusters prediction:
      cys
    Single AA prediction:
      cys
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLYNLSLIWK
    Nearest Stachelhaus code:
      cys
    Stachelhaus code match:
      100% (strong)
ctg1_215: cys
  Search NORINE for peptide: strict or relaxed
  AMP-binding (0..358): cys
  NRPSPredictor2: cys
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      cys
    Small clusters prediction:
      cys
    Single AA prediction:
      cys
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLwNMSMIWK
    Nearest Stachelhaus code:
      cys
    Stachelhaus code match:
      90% (moderate)
ctg1_216: cys
  Search NORINE for peptide: strict or relaxed
  AMP-binding (577..966): cys
  NRPSPredictor2: cys
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      cys
    Small clusters prediction:
      cys
    Single AA prediction:
      cys
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLFNLSLIWK
    Nearest Stachelhaus code:
      cys
    Stachelhaus code match:
      100% (strong)

NC_017168.1 - Region 3 - betalactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 510,293 - 537,080 nt. (total: 26,788 nt) Show pHMM detection rules used
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | betalactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001859.1 |  | 0.20 | Other (Phosphonate) | fosfomycin | Pseudomonas syringae
BGC0001891.1 |  | 0.19 | Other | closthioamide | Ruminiclostridium cellulolyticum H10
BGC0000904.1 |  | 0.16 | Other | FR-900098 | Streptomyces rubellomurinus
BGC0000794.1 |  | 0.16 | Saccharide | S-layer glycan | Geobacillus stearothermophilus
BGC0000375.1 |  | 0.15 | NRP | indigoidine | Streptomyces chromofuscus
BGC0001441.1 |  | 0.14 | Other | belactosin A, belactosin C | Streptomyces sp.
BGC0001150.1 |  | 0.13 | Polyketide | pamamycin-607 | Streptomyces alboniger
BGC0000805.1 |  | 0.13 | Saccharide | moenomycin | Streptomyces viridosporus ATCC 14672
BGC0000595.1 |  | 0.13 | RiPP | SCO-2138 | Streptomyces coelicolor A3(2)
BGC0000596.1 |  | 0.13 | RiPP | SLI-2138 | Streptomyces lividans TK24

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001859.1 |  | 0.52 | Other (Phosphonate) | fosfomycin | Pseudomonas syringae
BGC0001891.1 |  | 0.52 | Other | closthioamide | Ruminiclostridium cellulolyticum H10
BGC0000904.1 |  | 0.46 | Other | FR-900098 | Streptomyces rubellomurinus
BGC0000794.1 |  | 0.46 | Saccharide | S-layer glycan | Geobacillus stearothermophilus
BGC0000375.1 |  | 0.46 | NRP | indigoidine | Streptomyces chromofuscus
BGC0001441.1 |  | 0.43 | Other | belactosin A, belactosin C | Streptomyces sp.
BGC0001150.1 |  | 0.42 | Polyketide | pamamycin-607 | Streptomyces alboniger
BGC0000805.1 |  | 0.41 | Saccharide | moenomycin | Streptomyces viridosporus ATCC 14672
BGC0000595.1 |  | 0.41 | RiPP | SCO-2138 | Streptomyces coelicolor A3(2)
BGC0000596.1 |  | 0.41 | RiPP | SLI-2138 | Streptomyces lividans TK24

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_017168.1 - Region 4 - hserlactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,997,658 - 3,018,302 nt. (total: 20,645 nt) Show pHMM detection rules used
hserlactone: Autoind_synth

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | hserlactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000783.1 |  | 0.18 | Saccharide | O-antigen | Xanthomonas oryzae pv. oryzae
BGC0000780.1 |  | 0.18 | Saccharide | O&K-antigen | Vibrio parahaemolyticus
BGC0002009.1 |  | 0.15 | Polyketide | kanglemycin A, kanglemycin V1, kanglemycin V2 | Amycolatopsis vancoresmycina
BGC0000025.1 |  | 0.15 | Polyketide | avermectin | Streptomyces avermitilis
BGC0000843.1 |  | 0.14 | Other (Non-NRP beta-lactam) | alanylclavam, 2-hydroxymethylclavam, 2-formyloxymethylclavam, clavam-2-carboxylate | Streptomyces clavuligerus ATCC 27064
BGC0000010.1 |  | 0.14 | Polyketide | aflatoxin | Aspergillus flavus
BGC0001571.1 |  | 0.13 | Terpene | demethoxyviridin | Nodulisporium sp.
BGC0001578.1 |  | 0.11 | Polyketide | duclauxin | Talaromyces stipitatus ATCC 10500
BGC0000723.1 |  | 0.10 | Saccharide | β-D-galactosylvalidoxylamine-A | Streptomyces hygroscopicus subsp. limoneus
BGC0000158.1 |  | 0.09 | Polyketide | tautomycetin | Streptomyces griseochromogenes

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000783.1 |  | 0.50 | Saccharide | O-antigen | Xanthomonas oryzae pv. oryzae
BGC0000780.1 |  | 0.49 | Saccharide | O&K-antigen | Vibrio parahaemolyticus
BGC0002009.1 |  | 0.45 | Polyketide | kanglemycin A, kanglemycin V1, kanglemycin V2 | Amycolatopsis vancoresmycina
BGC0000025.1 |  | 0.45 | Polyketide | avermectin | Streptomyces avermitilis
BGC0000843.1 |  | 0.44 | Other (Non-NRP beta-lactam) | alanylclavam, 2-hydroxymethylclavam, 2-formyloxymethylclavam, clavam-2-carboxylate | Streptomyces clavuligerus ATCC 27064
BGC0000010.1 |  | 0.44 | Polyketide | aflatoxin | Aspergillus flavus
BGC0001571.1 |  | 0.42 | Terpene | demethoxyviridin | Nodulisporium sp.
BGC0001578.1 |  | 0.39 | Polyketide | duclauxin | Talaromyces stipitatus ATCC 10500
BGC0000723.1 |  | 0.36 | Saccharide | β-D-galactosylvalidoxylamine-A | Streptomyces hygroscopicus subsp. limoneus
BGC0000158.1 |  | 0.34 | Polyketide | tautomycetin | Streptomyces griseochromogenes

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_017168.1 - Region 5 - siderophore
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,900,994 - 3,921,313 nt. (total: 20,320 nt) Show pHMM detection rules used
siderophore: IucA_IucC

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | siderophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000941.1 |  | 0.42 | Other | desferrioxamin B | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001870.1 |  | 0.40 | Other | putrebactin, avaroferrin | Xenorhabdus budapestensis
BGC0001572.1 |  | 0.38 | Other | desferrioxamine E | Pantoea agglomerans
BGC0000295.1 |  | 0.34 | NRP | acinetoferrin | Acinetobacter haemolyticus
BGC0001478.1 |  | 0.29 | Other | desferrioxamine E | Streptomyces sp. ID38640
BGC0000940.1 |  | 0.29 | Other | desferrioxamin B, desferrioxamine E | Streptomyces coelicolor A3(2)
BGC0001453.1 |  | 0.29 | Other | desferrioxamine | Streptomyces argillaceus
BGC0001531.1 |  | 0.27 | Other | bisucaberin B | Tenacibaculum mesophilum
BGC0001713.1 |  | 0.24 | Other | ochrobactin | Ochrobactrum anthropi
BGC0000773.1 |  | 0.23 | Saccharide | lipopolysaccharide | Escherichia coli

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000941.1 |  | 0.74 | Other | desferrioxamin B | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001870.1 |  | 0.72 | Other | putrebactin, avaroferrin | Xenorhabdus budapestensis
BGC0001572.1 |  | 0.71 | Other | desferrioxamine E | Pantoea agglomerans
BGC0000295.1 |  | 0.68 | NRP | acinetoferrin | Acinetobacter haemolyticus
BGC0001478.1 |  | 0.63 | Other | desferrioxamine E | Streptomyces sp. ID38640
BGC0000940.1 |  | 0.62 | Other | desferrioxamin B, desferrioxamine E | Streptomyces coelicolor A3(2)
BGC0001453.1 |  | 0.62 | Other | desferrioxamine | Streptomyces argillaceus
BGC0001531.1 |  | 0.61 | Other | bisucaberin B | Tenacibaculum mesophilum
BGC0001713.1 |  | 0.57 | Other | ochrobactin | Ochrobactrum anthropi
BGC0000773.1 |  | 0.56 | Saccharide | lipopolysaccharide | Escherichia coli

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_017168.1 - Region 6 - PKS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
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Location: 3,989,676 - 4,030,959 nt. (total: 41,284 nt) Show pHMM detection rules used
PKS-like: (t2pks2 or ksIII)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | PKS-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001104.1 |  | 0.28 | NRP, Polyketide | myxovirescin A1 | Myxococcus xanthus DK 1622
BGC0000205.1 |  | 0.23 | Polyketide | bryostatin | Candidatus Endobugula sertula
BGC0000888.1 |  | 0.20 | Other | bacilysin | Bacillus sp. CS93
BGC0000219.1 |  | 0.19 | Polyketide, Saccharide | elloramycin | Streptomyces olivaceus
BGC0001184.1 |  | 0.19 | Other | bacilysin | Bacillus velezensis FZB42
BGC0001749.1 |  | 0.19 | Polyketide | epipyriculol | Pyricularia oryzae 70-15
BGC0000044.1 |  | 0.18 | Polyketide | dawenol | Stigmatella aurantiaca DW4/3-1
BGC0001591.1 |  | 0.18 | Other | fatty acid enol ester | uncultured bacterium CSLC2
BGC0001688.1 |  | 0.18 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSLC2
BGC0000837.1 |  | 0.18 | Other | APE Vf | Aliivibrio fischeri ES114

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001104.1 |  | 0.62 | NRP, Polyketide | myxovirescin A1 | Myxococcus xanthus DK 1622
BGC0000205.1 |  | 0.56 | Polyketide | bryostatin | Candidatus Endobugula sertula
BGC0000888.1 |  | 0.52 | Other | bacilysin | Bacillus sp. CS93
BGC0000219.1 |  | 0.51 | Polyketide, Saccharide | elloramycin | Streptomyces olivaceus
BGC0001184.1 |  | 0.51 | Other | bacilysin | Bacillus velezensis FZB42
BGC0001749.1 |  | 0.50 | Polyketide | epipyriculol | Pyricularia oryzae 70-15
BGC0000044.1 |  | 0.50 | Polyketide | dawenol | Stigmatella aurantiaca DW4/3-1
BGC0001591.1 |  | 0.50 | Other | fatty acid enol ester | uncultured bacterium CSLC2
BGC0001688.1 |  | 0.50 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSLC2
BGC0000837.1 |  | 0.49 | Other | APE Vf | Aliivibrio fischeri ES114

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
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Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
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NC_017168.1 - Region 7 - thiopeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,079,415 - 4,107,586 nt. (total: 28,172 nt) Show pHMM detection rules used
thiopeptide: ((YcaO or TIGR03882) and ((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or PF07366 or PF06968 or PF04055) or thiostrepton)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Thiopeptides
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | thiopeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001285.1 |  | 0.07 | Other (Fatty acid) | pseudopyronine A, pseudopyronine B | Pseudomonas putida
BGC0001302.1 |  | 0.06 | Other | lomofungin | Streptomyces lomondensis
BGC0002012.1 |  | 0.05 | Polyketide | julichrome Q3-3, julichrome Q3-5 | Streptomyces afghaniensis 772
BGC0001283.1 |  | 0.05 | Polyketide | arsono-polyketide | Streptomyces lividans 1326
BGC0000957.1 |  | 0.04 | NRP, Polyketide | mycotrienin I | Streptomyces sp. XZQH13
BGC0001448.1 |  | 0.03 | NRP | malacidin A, malacidin B | uncultured bacterium

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001285.1 |  | 0.29 | Other (Fatty acid) | pseudopyronine A, pseudopyronine B | Pseudomonas putida
BGC0001302.1 |  | 0.24 | Other | lomofungin | Streptomyces lomondensis
BGC0002012.1 |  | 0.23 | Polyketide | julichrome Q3-3, julichrome Q3-5 | Streptomyces afghaniensis 772
BGC0001283.1 |  | 0.22 | Polyketide | arsono-polyketide | Streptomyces lividans 1326
BGC0000957.1 |  | 0.19 | NRP, Polyketide | mycotrienin I | Streptomyces sp. XZQH13
BGC0001448.1 |  | 0.17 | NRP | malacidin A, malacidin B | uncultured bacterium

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Thiopeptide predictions
Lists the possible core peptides for each biosynthetic enzyme, including the predicted class. Each core peptide shows the leader and core peptide sequences, separated by a dash. Predicted tail sequences are also shown.
No core peptides found.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
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Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
Thiopeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists its possible molecular weights and the scores for cleavage site prediction and RODEO. If relevant, other features, such as macrocycle and amidation, will also be listed.
No core peptides found.
NC_017168.1 - Region 8 - NRPS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,493,043 - 4,536,456 nt. (total: 43,414 nt) Show pHMM detection rules used
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001909.1 |  | 0.23 | Polyketide | strobilurin | Strobilurus tenacellus
BGC0001831.1 |  | 0.21 | Polyketide | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0001897.1 |  | 0.17 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10
BGC0001275.1 |  | 0.17 | Polyketide | 6-methylsalicyclic acid | Glarea lozoyensis
BGC0001276.1 |  | 0.16 | Polyketide | 6-methylsalicyclic acid | Aspergillus terreus
BGC0001998.1 |  | 0.16 | Polyketide | aspernidgulene A1, aspernidgulene A2, aspernidgulene B1 | Aspergillus nidulans FGSC A4
BGC0000180.1 |  | 0.16 | Polyketide | legioliulin | Legionella parisiensis
BGC0000794.1 |  | 0.16 | Saccharide | S-layer glycan | Geobacillus stearothermophilus
BGC0001219.1 |  | 0.15 | Polyketide | shanorellin | Chaetomium globosum CBS 148.51
BGC0001049.1 |  | 0.15 | NRP, Polyketide | tenellin | Beauveria bassiana

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001909.1 |  | 0.56 | Polyketide | strobilurin | Strobilurus tenacellus
BGC0001831.1 |  | 0.53 | Polyketide | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0001897.1 |  | 0.48 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10
BGC0001275.1 |  | 0.47 | Polyketide | 6-methylsalicyclic acid | Glarea lozoyensis
BGC0001276.1 |  | 0.47 | Polyketide | 6-methylsalicyclic acid | Aspergillus terreus
BGC0001998.1 |  | 0.47 | Polyketide | aspernidgulene A1, aspernidgulene A2, aspernidgulene B1 | Aspergillus nidulans FGSC A4
BGC0000180.1 |  | 0.46 | Polyketide | legioliulin | Legionella parisiensis
BGC0000794.1 |  | 0.46 | Saccharide | S-layer glycan | Geobacillus stearothermophilus
BGC0001219.1 |  | 0.45 | Polyketide | shanorellin | Chaetomium globosum CBS 148.51
BGC0001049.1 |  | 0.45 | NRP, Polyketide | tenellin | Beauveria bassiana

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names