LOCUS       NZ_CP046293.1          12715 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP046293.1 Yersinia intermedia strain FDAARGOS_730 chromosome,
            complete genome.
ACCESSION   NZ_CP046293
VERSION     NZ_CP046293.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 13:59:39
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 4500263
            Orig. end    :: 4512978
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12715
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[4505263:4507978](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..7715)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..12715
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12715
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="7"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             455..1222
                     /locus_tag="ctg1_4099"
                     /transl_table=11
                     /translation="MRMRKWLYVSNNVMLKRVNSKMSGWLLLLIMACSLPATASVVAER
                     TRVIFSEGNTEESLQLVNSNSYPVAVQVWVDDGDLAATPEKSISPVLVLPPLFRLQPQA
                     QRSLRLILSGASKLPVDRESAFWLNVYEIPPKATPKTEDESLVTLALRMQYKVFYRPKS
                     LQAPGDTLGKALTFTLETKGDTALIRVDNPTPYYASLASLTLGSTESLPDMVAPFSKLD
                     FPLNRFPPAGSKTVNFVLIDDLGNRKAFSNNLK"
     PFAM_domain     575..946
                     /aSDomain="PapD_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00345.22"
                     /description="Pili and flagellar-assembly chaperone, PapD
                     N-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_4099_0150"
                     /evalue="7.30E-40"
                     /label="ctg1_4099"
                     /locus_tag="ctg1_4099"
                     /protein_end="164"
                     /protein_start="40"
                     /score="135.9"
                     /tool="antismash"
                     /translation="VVAERTRVIFSEGNTEESLQLVNSNSYPVAVQVWVDDGDLAATPE
                     KSISPVLVLPPLFRLQPQAQRSLRLILSGASKLPVDRESAFWLNVYEIPPKATPKTEDE
                     SLVTLALRMQYKVFYRPKSL"
     PFAM_domain     1022..1195
                     /aSDomain="PapD_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02753.19"
                     /description="Pili assembly chaperone PapD, C-terminal
                     domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_4099_0151"
                     /evalue="3.80E-13"
                     /label="ctg1_4099"
                     /locus_tag="ctg1_4099"
                     /protein_end="247"
                     /protein_start="189"
                     /score="49.7"
                     /tool="antismash"
                     /translation="VDNPTPYYASLASLTLGSTESLPDMVAPFSKLDFPLNRFPPAGSK
                     TVNFVLIDDLGNR"
     CDS             complement(1406..1771)
                     /locus_tag="ctg1_4100"
                     /transl_table=11
                     /translation="MSNIQTVLARWGVWARENIHLDYPHIANGFKGMVMRNKPAESCCD
                     NDGLVIDKTIGNLQRASREKELELILRHYVYGQSKASIARLKKCNEREIRRQLQLAESF
                     IEGGIVQSDAALEMHME"
     PFAM_domain     complement(1421..1771)
                     /aSDomain="Phage_antitermQ"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF06530.14"
                     /description="Phage antitermination protein Q"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_4100_0152"
                     /evalue="7.20E-36"
                     /label="ctg1_4100"
                     /locus_tag="ctg1_4100"
                     /protein_end="117"
                     /protein_start="0"
                     /score="122.8"
                     /tool="antismash"
                     /translation="MSNIQTVLARWGVWARENIHLDYPHIANGFKGMVMRNKPAESCCD
                     NDGLVIDKTIGNLQRASREKELELILRHYVYGQSKASIARLKKCNEREIRRQLQLAESF
                     IEGGIVQSDAALE"
     CDS             complement(2401..2496)
                     /locus_tag="ctg1_4101"
                     /transl_table=11
                     /translation="MELKNSISEYTELEFLVFLKNFGRRCFREGT"
     CDS             complement(2950..3270)
                     /locus_tag="ctg1_4102"
                     /transl_table=11
                     /translation="MNKELKLFDDVLYISNAEYIYNDLHSIQKDDRLSDVIDLLDEDLL
                     QIKYLNGSIVDVGWYPSFDESGYFKVMSIRHDDWENPIYSSTLGFSLNQLLEEIKMAIS
                     KI"
     CDS             complement(4011..4274)
                     /locus_tag="ctg1_4103"
                     /transl_table=11
                     /translation="MSNMEKIIKNETVEDVLLAFTPNTAYQGIDRMYVKYHFDVVANRE
                     LLFTYQRLIKEGKLAEDDKGHTLKGPNWKEPKFVTDKKYDAE"
     CDS             complement(4278..4541)
                     /locus_tag="ctg1_4104"
                     /transl_table=11
                     /translation="MIERLERILMGELTATDIDKRFYTHEIRELERYRALGVPDGVNDK
                     SVWNDAHTATLEDYKVNEKKEPLYTPEAEDAYIKAELKIFRR"
     CDS             complement(4745..4999)
                     /locus_tag="ctg1_4105"
                     /transl_table=11
                     /translation="MEGNTISDYTESEFLEFVKKLFNVENTSEEDDIQNLLKFKRLCEH
                     PAGSDLIYYPEAHQDDSPEGVVSEIKKWRAENGKPGFKE"
     PFAM_domain     complement(4751..4990)
                     /aSDomain="Colicin_Pyocin"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01320.20"
                     /description="Colicin immunity protein / pyocin immunity
                     protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_4105_0153"
                     /evalue="1.20E-34"
                     /label="ctg1_4105"
                     /locus_tag="ctg1_4105"
                     /protein_end="83"
                     /protein_start="3"
                     /score="118.3"
                     /tool="antismash"
                     /translation="NTISDYTESEFLEFVKKLFNVENTSEEDDIQNLLKFKRLCEHPAG
                     SDLIYYPEAHQDDSPEGVVSEIKKWRAENGKPGFK"
     CDS             complement(5001..7715)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Cloacin"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_4106"
                     /sec_met_domain="Cloacin (E-value: 1.9e-38, bitscore:
                     130.2, seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGKGHSNIMGHGRHGPTGGRNPNSGRGWGVSQTPYGPLRHYSPSL
                     FDGNDNLAQRPELQVAIVPGVAVPLSLVAGEWGFTLLKPKVVAAALDLALTRMAMFAVD
                     AAPYAGRFAGVVGMLLAPSEIAKDDMSVIRRTVVTLPADKITTMPLAQLPTQPAVVADV
                     RLHDVVQDGVQKIAIVKSKHVPIAVPVVQAKPTDRTGVFTAQILNGMPPIHIHVDTSSS
                     PPTAMQPSGISEVRDSPVTPVFSPLGSHSHDAIVYFPVETNTDPVYISVTTVLTPEQIT
                     QVEAENRQKQAQWDANYPVEAAEYQLSQANDALAQEQNNIVPYQAALDELKGTWEGRLL
                     DDPDRYPFRDEIEEFISISSSSRYRFMFDIEIKNRQELENLLNIGGEAFDPFPDGMSPE
                     EMEYYGYHAGLLMQALTIGHYDLLRKHLLAYQANINTAQLALDSIQHQLDMAINAVNNA
                     EQHLTQVRANVENVSLTAETAEWLRPAEFEQWNAEVTERWRLKDEQRAIEIAEWQQRVE
                     RERLAAQAADGFAKQQIAIRNNSFSLPAHPKGSTHTPGFAGVGMGTIALSSPVARGFSA
                     TLRTALARFSTIAPTLLARPIAMTVGSGFYPTKVGGPDKPALVGSFPLSEMGLPPATPL
                     PQQGEIDLPVRMLMTGQDDWTDVYAVKTGAANIAAKVKVTTAQFDQSKGVYTFTTDSQP
                     PRTFIFTPAQPPGMDISSVLPQPPSAPVVPSHTGADITFLATKPSLIFLALEEGDFHDY
                     IIWFPAASGLEPVYIYLKTPRDEPGEVTGRGQQVAGVWLAEAGKGLGAPIPVQIADKLR
                     GRKFSSFGEFRRALWLEISKDPTLSEQFKSGNLGNIKNGKAPSPRESEQVGGRVKHELH
                     HVKPISKGGAVYDIDNIRVLTPKRHIKIHKEVK"
     PFAM_domain     complement(5409..5813)
                     /aSDomain="Pyocin_S"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF06958.14"
                     /description="S-type Pyocin"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_4106_0155"
                     /evalue="4.50E-33"
                     /label="ctg1_4106"
                     /locus_tag="ctg1_4106"
                     /protein_end="769"
                     /protein_start="634"
                     /score="114.8"
                     /tool="antismash"
                     /translation="LPQQGEIDLPVRMLMTGQDDWTDVYAVKTGAANIAAKVKVTTAQF
                     DQSKGVYTFTTDSQPPRTFIFTPAQPPGMDISSVLPQPPSAPVVPSHTGADITFLATKP
                     SLIFLALEEGDFHDYIIWFPAASGLEPVYIY"
     PFAM_domain     complement(6840..7589)
                     /aSDomain="Cloacin"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03515.16"
                     /description="Colicin-like bacteriocin tRNase domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_4106_0154"
                     /evalue="4.60E-45"
                     /label="ctg1_4106"
                     /locus_tag="ctg1_4106"
                     /protein_end="292"
                     /protein_start="42"
                     /score="154.5"
                     /tool="antismash"
                     /translation="PSLFDGNDNLAQRPELQVAIVPGVAVPLSLVAGEWGFTLLKPKVV
                     AAALDLALTRMAMFAVDAAPYAGRFAGVVGMLLAPSEIAKDDMSVIRRTVVTLPADKIT
                     TMPLAQLPTQPAVVADVRLHDVVQDGVQKIAIVKSKHVPIAVPVVQAKPTDRTGVFTAQ
                     ILNGMPPIHIHVDTSSSPPTAMQPSGISEVRDSPVTPVFSPLGSHSHDAIVYFPVETNT
                     DPVYISVTTVLTPEQITQVEAENRQKQA"
     CDS             complement(8131..9609)
                     /locus_tag="ctg1_4107"
                     /transl_table=11
                     /translation="MANYFNTLNLRQQLAQLGKCRFMARDEFADEASYLKGKKVVIVGC
                     GAQGLNQGLNMRDSGLDVAYALRKEAIAEKRASWRKATENGFKVGTYEDLIPQADLVVN
                     LTPDKQHSAVVQAVQPLMKDGAALGYSHGFNIVEVGEQVRKDITVVMVAPKCPGTEVRE
                     EYKRGFGVPTLIAVHPENDPKGEGMAIAKAWAAATGGHRAGVLESSFVAEVKSDLMGEQ
                     TILCGMLQAGSLLCFDKLVSEGTDAAYAEKLIQFGWETITEALKQGGITLMMDRLSNPA
                     KLRAYALSEQLKEIMAPLFQKHMDDIISGAFSSGMMADWAQDDVKLLNWREETGRTAFE
                     NAPQFDGKISEQEYFDHGVLMIAMVKAGVELAFETMVDSGIIEESAYYESLHELPLIAN
                     TIARKRLYEMNVVISDTAEYGNYLFANAAVPLLKGKFMDSLQAGDLGKSVAGTAVDNAQ
                     LRDVNEAIRNHPIEAVGHKLRGYMTDMKRIAVAG"
     PFAM_domain     complement(8164..8532)
                     /aSDomain="IlvC"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01450.21"
                     /description="Acetohydroxy acid isomeroreductase, catalytic
                     domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_4107_0158"
                     /evalue="1.70E-16"
                     /label="ctg1_4107"
                     /locus_tag="ctg1_4107"
                     /protein_end="482"
                     /protein_start="359"
                     /score="60.9"
                     /tool="antismash"
                     /translation="LMIAMVKAGVELAFETMVDSGIIEESAYYESLHELPLIANTIARK
                     RLYEMNVVISDTAEYGNYLFANAAVPLLKGKFMDSLQAGDLGKSVAGTAVDNAQLRDVN
                     EAIRNHPIEAVGHKLRGYM"
     aSDomain        complement(8506..9507)
                     /aSDomain="TIGR00465"
                     /aSTool="tigrfam"
                     /description="ilvC: ketol-acid reductoisomerase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_4107_0047"
                     /evalue="4.60E-134"
                     /identifier="TIGR00465"
                     /label="ctg1_4107"
                     /locus_tag="ctg1_4107"
                     /protein_end="368"
                     /protein_start="34"
                     /score="444.3"
                     /tool="antismash"
                     /translation="LKGKKVVIVGCGAQGLNQGLNMRDSGLDVAYALRKEAIAEKRASW
                     RKATENGFKVGTYEDLIPQADLVVNLTPDKQHSAVVQAVQPLMKDGAALGYSHGFNIVE
                     VGEQVRKDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPENDPKGEGMAIAKAWAAA
                     TGGHRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSLLCFDKLVSEGTDAAYAEKLIQF
                     GWETITEALKQGGITLMMDRLSNPAKLRAYALSEQLKEIMAPLFQKHMDDIISGAFSSG
                     MMADWAQDDVKLLNWREETGRTAFENAPQFDGKISEQEYFDHGVLMIAMVKAG"
     PFAM_domain     complement(8584..8982)
                     /aSDomain="IlvC"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01450.21"
                     /description="Acetohydroxy acid isomeroreductase, catalytic
                     domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_4107_0157"
                     /evalue="7.90E-25"
                     /label="ctg1_4107"
                     /locus_tag="ctg1_4107"
                     /protein_end="342"
                     /protein_start="209"
                     /score="87.9"
                     /tool="antismash"
                     /translation="FVAEVKSDLMGEQTILCGMLQAGSLLCFDKLVSEGTDAAYAEKLI
                     QFGWETITEALKQGGITLMMDRLSNPAKLRAYALSEQLKEIMAPLFQKHMDDIISGAFS
                     SGMMADWAQDDVKLLNWREETGRTAFENA"
     PFAM_domain     complement(8998..9507)
                     /aSDomain="IlvN"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07991.14"
                     /description="Acetohydroxy acid isomeroreductase,
                     NADPH-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_4107_0156"
                     /evalue="1.70E-58"
                     /label="ctg1_4107"
                     /locus_tag="ctg1_4107"
                     /protein_end="204"
                     /protein_start="34"
                     /score="197.0"
                     /tool="antismash"
                     /translation="LKGKKVVIVGCGAQGLNQGLNMRDSGLDVAYALRKEAIAEKRASW
                     RKATENGFKVGTYEDLIPQADLVVNLTPDKQHSAVVQAVQPLMKDGAALGYSHGFNIVE
                     VGEQVRKDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPENDPKGEGMAIAKAWAAA
                     TGGHRAG"
     CDS             9873..10754
                     /gene_functions="regulatory (smcogs) SMCOG1014:LysR family
                     transcriptional regulator (Score: 182.2; E-value: 2.1e-55)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_4108"
                     /transl_table=11
                     /translation="MDLRDLKLFLHLAESRHFGRTAKATHVSPSTLSRQIQRLEETLGQ
                     PLFLRDNRTVQLTDAGTQLKAFAQQTLLQYQQLRHALGQHGPSLSGELRLFCSVTAAYS
                     HLPPILDRFRARHPLVEIKLTTGDAADAVDKVQSNEADLGIAGRPEVLPTSIAFTQIGE
                     IPLVLIAPALPCAVRSQVSVEQPDWATVPFILPEHGPSRKRIDLWFRRQRISNPLIYAT
                     VSGHEAIVSMVALGCGVALIPSVVVDNSPEPVRNRISLLDDISLVEPFELGVCVPKKRL
                     NEPLIEAFWGLL"
     PFAM_domain     9879..10055
                     /aSDomain="HTH_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00126.29"
                     /description="Bacterial regulatory helix-turn-helix
                     protein, lysR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_4108_0159"
                     /evalue="4.50E-20"
                     /label="ctg1_4108"
                     /locus_tag="ctg1_4108"
                     /protein_end="61"
                     /protein_start="2"
                     /score="71.5"
                     /tool="antismash"
                     /translation="LRDLKLFLHLAESRHFGRTAKATHVSPSTLSRQIQRLEETLGQPL
                     FLRDNRTVQLTDAG"
     PFAM_domain     10137..10751
                     /aSDomain="LysR_substrate"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03466.22"
                     /description="LysR substrate binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_4108_0160"
                     /evalue="1.50E-40"
                     /label="ctg1_4108"
                     /locus_tag="ctg1_4108"
                     /protein_end="293"
                     /protein_start="88"
                     /score="138.9"
                     /tool="antismash"
                     /translation="LSGELRLFCSVTAAYSHLPPILDRFRARHPLVEIKLTTGDAADAV
                     DKVQSNEADLGIAGRPEVLPTSIAFTQIGEIPLVLIAPALPCAVRSQVSVEQPDWATVP
                     FILPEHGPSRKRIDLWFRRQRISNPLIYATVSGHEAIVSMVALGCGVALIPSVVVDNSP
                     EPVRNRISLLDDISLVEPFELGVCVPKKRLNEPLIEAFWGLL"
     CDS             complement(10756..11403)
                     /locus_tag="ctg1_4109"
                     /transl_table=11
                     /translation="MSETLASIKASIKSSAPDYIPPTQLSRRSDPLQYSIESYSGARVS
                     KTIETTHNRDKVVREVVTTERIGPANNKIINIRTYDATTNTINKAIEHFDSNNNMTKRV
                     VKSFSYDPVKKAVQLGETVVVKQSFDAKNNITHRAEQKFNAAGKITYNVIDTYPNVNIT
                     NNLRSDICQLTNSINSFPTKESTPVPVEATIGNHLNLGLRNLVPAMNYASRL"
ORIGIN
        1 gtagtattac cgagaatttc tgtggcagaa ctgaacagtg gtggcaccac ttcggctgaa
       61 tttagagtag attttcaatg ccagaccggc gtgacatctg gtgtcacttc tggcacggta
      121 gccatgggtt tcctggtgcc agcagcaaat gccgccaaag cgcaagcctt gggtttaatg
      181 aatggcagtg gagggattag ccatttggta tcagatagtt atggctctcc aggcacagcg
      241 agcggcgttg gaattcgtat ctaccggaac aatgccccaa tttatctgtt atcaaagaat
      301 gtaacgctat cgggtaacaa tggcggttgg tatggcatct tccagggtgc acaagaatta
      361 accggcgcgg tgagtggtgg caacagttac actgagagtt ttcgggctga gttaactaaa
      421 atcagcgggc aaactgtgac agcaggagca gtaaatgcgc atgcgcaagt ggttatacgt
      481 gtccaataat gtgatgttga aacgtgtaaa tagtaagatg agcggctggc ttctattact
      541 cataatggcc tgtagtctgc ccgccacagc aagcgtagtt gcagaaagga cacgcgttat
      601 cttcagcgag ggtaatacgg aagaatcgct gcaactggtt aacagcaata gctacccggt
      661 ggcggtacag gtttgggtgg atgacggtga tttagcggca actccagaga aatctatttc
      721 accggtatta gtgttgcccc cgctatttcg gttacaacca caggcacaac gcagcctgcg
      781 attaatctta tcgggcgcca gtaaattacc tgtagatagg gaatctgcat tttggctcaa
      841 tgtttacgaa atcccgccaa aggcaacgcc taaaacggag gacgaatctc tcgtcacact
      901 ggccctacgc atgcaataca aagtatttta ccgccctaaa agcttacaag ccccaggcga
      961 taccttaggt aaagcgttaa cctttaccct tgagacaaaa ggcgataccg ccctgattcg
     1021 agttgataac ccgacgcctt attatgcatc attagcttca ttaacattag gctcaactga
     1081 aagcttgcca gatatggttg ctcctttttc caagcttgat tttccactca atcgttttcc
     1141 ccccgctggc agcaagaccg tcaattttgt cctaattgat gatttaggta accgaaaggc
     1201 atttagcaac aatttaaaat aaaaacctta atgaatataa actgccgcaa agacagttta
     1261 tattctggtt tcgggttacc atggacagcc gcacacctta ttcttactct acttcacttc
     1321 gtattgagtc ctacacacca atgctataat ccattattta atcctctatt ctattaaacc
     1381 tcattatatt tagaaactat agaaatcact ccatatgcat ttccagtgcg gcatctgatt
     1441 gtacgatacc gccttcaata aaactttcag ccagttgtaa ttgacgccta atttcccgct
     1501 cattacattt tttcaatcgg gcaatagagg ctttagattg cccatacaca taatgtcgca
     1561 ggatcagttc cagttctttt tctcgcgagg ctcgctgtaa attccctatt gttttatcaa
     1621 taaccaatcc gtcattatcg caacatgact cagccggttt atttctcatt accatgccct
     1681 taaaaccatt ggcaatatgg ggataatcca gatgaatatt ttctctggcc catactcccc
     1741 agcgcgccaa cacagtttga atgttactca ttacctatct ccttttatat ttaaatacct
     1801 ttttatttaa ctaatatcgc ctcacaatac tcgcgaaaac agacttaacc aaccagtgag
     1861 gtatatctat taataagatt gaaaacagat gctattctaa tagatttcaa tattcaggca
     1921 ggcgataaat gagaacgccc caataaactt acataacgga tgccctcatc caaccaacgc
     1981 gcctgcaact tgaaggattt atctgtggtg tgttaaacca cgatcaacac cttacaagat
     2041 ttttttcggg ccgagatagc attaatttaa ttaatttccc cgcccatgag atgaataggt
     2101 atttttgaaa gaaaagtcaa cacatcctca ccttaattat tttaaagtta catcacataa
     2161 ttcacacatc atttatataa taataaatca acccaatata aaccgccgac aatgtgggtt
     2221 atattattat ttagctatat aagttactct ttgaatccag gtttgccatt ttcggcccgc
     2281 cattttttaa tgaattcaag aataccttcg ggactattat caacgtctga atcgggataa
     2341 aatagcaatc cattcccgtg aggatgctca gtgagcatta caaaatgatg aataagagca
     2401 tcatgttcct tctctgaaac atctacggcc aaaatttttt aaaaaaacta aaaattccaa
     2461 ctcagtatat tcacttatac tattttttaa ttccattact cgcctccatt ctttgagtga
     2521 atatttacat gtcgttttgg tgtcattacc cttatatttt caatgtcata aactgcacca
     2581 tcatcacgaa taaatttaat atgatgaagc tcaaatttct ctcttcctcc tacttgctca
     2641 gttggtattg gatatggagc ataaccacgt ttcattctat tctggtttaa aggtgagaac
     2701 tgcccagata gctcaggatc attcgcaacc tcctgccaaa acgctgccct aaatctatca
     2761 aaactactga acttcctgcc acgtaattta tcggcaatct gtactgggat gggtgctccc
     2821 agctactaat aatctgagga ccaaatgata taataaatga gtgtttatgt ttttattaac
     2881 taattaataa aatataaacc gccagaaagg cggcctatat tataattttg gaaaccaagt
     2941 ggccaatagt taaatttttg atatggccat tttgatttct tccaacaact ggttaaggct
     3001 aaatcctaaa gtgctggagt aaatgggatt ctcccagtca tcatgtctaa tagacataac
     3061 tttaaaataa ccactctcgt caaaagaggg ataccaacca acatcaacaa tagagccatt
     3121 cagatatttt atctgtagta gatcctcatc aagaaggtca ataacatctg acaacctatc
     3181 atctttttga atagaatgca gatcgttata tatatattca gcattactta tatataatac
     3241 gtcatcaaat aattttaatt ctttgttcat tttattaatc tcctggattc ggcttcacca
     3301 attggatgag agtgaataac accccccgat tctttagtta ctacccagca agtttccttt
     3361 cctttatatg caccttgaac atctctaaat tccttaactt tccaagattg accattagtt
     3421 actgaaatcc ctgtcaacca aacttcttga tcaacttcag ggatattaac accttgtttg
     3481 aattttgccg gacctgattt agtcgagtta acaatatcgt cccacttcat attcttgggt
     3541 gggtaatgtt tgaaaccatg agaatacgac tctttagatt tacttagata aatatacacc
     3601 ggttccagcc ccgacgctgc cgggaaccaa atgatgtaat aaatagagta tttatatttc
     3661 agcaactaat taataaagta cttatactta tctattgtaa tgatattttt aaaatgtggt
     3721 tgaatagata tcatccagtt ctatgctact tcacccccgt aattcatcgt atcatccaaa
     3781 ggaagctcta atatctcgat gatagtatca tcacccccaa aatccttata aaatctcatg
     3841 ccaactaaca catcagtttt tatcaaacca aattagtcgt aattttagcc ccacaattca
     3901 tatcataaat atattcacat taatatcata atcagtaatc ataaaaaaca accagtaaca
     3961 tccttgttca ctgattatta attacaataa atttttagta atgttgaaca ttattccgca
     4021 tcgtattttt tgtcggttac gaatttcggt tctttccagt tgggaccttt gagtgtatgc
     4081 cctttatcat cttcagccaa cttaccttct tttattaacc tctgatatgt aaataaaagc
     4141 tctcggttag ctaccacatc aaaatgatat ttcacataca ttcgatcaat accttgatat
     4201 gctgtattag gagtgaaggc taatagaaca tcttcgactg tttcattttt aattattttt
     4261 tccatatttg acattattta tctcctaaat atttttaact ctgcttttat atatgcatcc
     4321 tcagcttctg gcgtatataa aggctctttt ttttcattaa ccttatagtc ctccagagtt
     4381 gcggtatgag cgtcattcca aacagattta tcattaacac catccggcac ccctagcgca
     4441 cgatatcgtt ctagctctct gatttcatga gtataaaagc gtttatcaat atcagtggcc
     4501 gtgagttccc ccatcaagat tcgctccagc cgctcgatca tcagcttatt atcctctaat
     4561 tcatcaaaac tactgaacgt cctgccacgt aatttatcgg caatctgtac tgggatggga
     4621 gctcccagcc actaataatc tgaggaccaa atgatataat aaatgagtgt ttatatttta
     4681 ttaactaatt aataaaatat aacccgccag aaaagcggcc tatattttta cttaacgata
     4741 taagttactc tttgaatcca ggcttgccat tttcggctcg ccattttttt atttcactca
     4801 cgacaccttc aggactatca tcctgatgag cttctgggta gtagataaga tcagacccgg
     4861 caggatgctc acatagtctt ttaaatttaa gaaggttttg aatatcgtct tcttcagatg
     4921 tattttccac attgaacagt ttttttacga actctaaaaa ctcagattcc gtgtaatcag
     4981 atatagtgtt tccttccata ttacttcacc tctttatgaa tttttatatg cctcttaggc
     5041 gttaacactc taatattatc aatatcgtaa acggcaccac ctttactgat aggtttcaca
     5101 tgatgcagtt catgttttac ccgaccaccg acttgctcac tttctctagg cgatggagcc
     5161 ttgccattct taatattccc taaattacca gatttaaact gttccgataa agttggatct
     5221 ttagatattt ccaaccataa agccctacga aactcaccaa aactactgaa cttcctgcca
     5281 cgtaatttat cggcaatctg tactgggatg ggtgctccca gccccttacc cgcctctgcc
     5341 aaccaaacgc ctgcaacttg ctgcccacga ccggttactt cacccggctc atcccgtggc
     5401 gttttaagat aaatatacac cggttccagc cccgacgctg ccgggaacca aatgatgtaa
     5461 tcgtggaaat caccctcttc cagagccaga aatattaagc tcggcttggt agccaggaag
     5521 gtgatatcag ccccagtatg cgacggaaca accggtgcac tgggcggttg tggcaatacc
     5581 gagctgatat ccatgccggg cggttgtgct ggcgtaaaaa taaaggtgcg tggcggctga
     5641 ctgtcggtgg taaaagtata aacacctttt gattgatcaa attgggcagt ggtaaccttt
     5701 accttagcgg caatatttgc ggcaccggtt tttactgcat aaacatccgt ccaatcatcc
     5761 tgacccgtca tcagcattct gacaggaaga tcaatttcac cttgctgcgg tagcggtgtt
     5821 gcagggggta accccatttc gctaagcggg aaactaccca caagtgcagg tttatctggc
     5881 cctcctacct tggttgggta gaaaccagaa ccaacagtca ttgctattgg tctagctaac
     5941 aaggtgggag caatcgtact gaatctcgcc aatgctgtcc gtaacgtggc gctaaatcct
     6001 ctggctaccg gggaacttaa ggcaatcgtc cccattccta ccccggcaaa accaggcgta
     6061 tgggtacttc ctttcggatg agcgggtaaa gaaaagctat tgttacgaat agctatttgc
     6121 tgtttagcaa agccgtctgc cgcttgtgcc gccagtcgct cacgctcaac gcgctgttgc
     6181 cattcagcta tctctattgc ccgctgctca tccttaagtc gccaccgttc tgttacttcg
     6241 gcattccatt gctcaaactc agcaggtcgc aaccattctg cggtttctgc cgtcaaagat
     6301 acattctcaa cattagctct aacctgagtt aaatgctgct cagcgttatt gacggcattt
     6361 atagccatat ctaattggtg ttgaatagaa tctaaagcca actgagccgt gttaatatta
     6421 gcctgataag ccaacaggtg tttacgcaac agatcataat gcccaatcgt taacgcctgc
     6481 atgagcaacc cagcatgata tccatagtat tccatctctt ctggactcat gccatcaggg
     6541 aagggatcaa aggcttcacc gccaatattt aatagattct ccagctcctg gcggttcttt
     6601 atctcaatgt cgaacataaa acggtatcta gagctactcg atatagagat gaattcttcg
     6661 atttcatctc taaaagggta tcgatcagga tcgtctaaaa gacgcccttc ccaggtcccc
     6721 ttaagctcat ccagtgccgc ctgatagggt acaatattat tctgctcctg ggccaaagcg
     6781 tcattcgcct ggcttaactg gtattccgcc gcttcaaccg gataattggc atcccattgt
     6841 gcttgttttt gccgattttc cgcctccacc tgcgtaatct gctctggcgt caatacagtc
     6901 gtgaccgaga tatagaccgg gtcggtattc gtttctacgg ggaagtagac aatcgcgtca
     6961 tggctgtggc tccccagtgg agaaaatacc ggtgttactg ggctatccct cacctcacta
     7021 ataccgcttg gttgcattgc cgtgggaggg gaggaactcg tatcaacatg gatgtggata
     7081 ggtggcatgc cattgaggat ctgagcggta aatacccctg tccgatcagt gggtttcgcc
     7141 tgcaccactg gcaccgcaat cggcacatgt ttggatttca ctatagcgat tttctgcacg
     7201 ccatcctgta ccacatcatg caaccggaca tctgccacta ccgcaggctg cgtaggtaac
     7261 tgtgcaagtg gcatggtcgt gatcttgtcg gcaggcagcg tgacaacggt acgccggatc
     7321 actgacatat catctttcgc gatttcagag ggtgccagca acatgccaac aaccccggcg
     7381 aaccgcccgg cataaggtgc cgcatccacg gcaaacatcg ccatccgcgt aagagccaga
     7441 tcaagtgccg cagcaactac ctttggttta agcagcgtaa acccccattc accagcaacc
     7501 agtgataggg gaacggcaac accagggact attgctactt gtagctctgg cctttgtgcc
     7561 agattatcgt tgccatcaaa tagactcggg ctgtagtggc gaagagggcc ataaggtgtt
     7621 tgtgatactc cccatcccct gccactgttg gggtttctgc ccccggttgg gccatgccta
     7681 ccatgcccca ttatattact gtgtcctttt cccatacttt atttccttat ttaaactttt
     7741 ataattaacg agaatattta ctgctaaatc tatttgtctt ttctcacccc cttaacatta
     7801 tttaaatgcc attatttttt attattcagc tttgccagac cctcaaataa aaacacctcg
     7861 ctaattagcg aggtgcgtga ttaccttcat aataatattg tgattgatag cgtttaatac
     7921 tgcatttatc tgcgatgtgt taaaccacga ttaacacctt actggatttt tttcgggccg
     7981 tgatagtatt aatttaataa atttttgtat tcgagaaatg tactaaatct gagataaaaa
     8041 aaagccgctg ccattattta atggcagcgg cctgtttcac gcagagttaa acgccgctaa
     8101 caacgcagcg gcgtcaaaga caaaagggac ttagcccgca actgcgatac gtttcatatc
     8161 ggtcatatag ccacgcagtt tgtggcctac ggcttcaatt gggtggttac gaatggcttc
     8221 attcacatca cgcaattgcg cgttatcaac cgcagtaccg gcaacgctct tacccaaatc
     8281 ccctgcttgc agtgaatcca tgaatttgcc tttcagcaat ggaaccgctg cgttagcgaa
     8341 caggtagtta ccatattcag ccgtatcaga aataaccacg ttcatttcat ataagcgctt
     8401 acgagcgatg gtattggcga tcaatggcag ctcatgcaga gattcataat acgcagattc
     8461 ttcaatgata ccggaatcaa ccatggtttc gaatgccagc tcaacgcctg ctttcaccat
     8521 agcaatcatc agtacaccgt ggtcaaagta ttcttgctct gagattttgc catcgaattg
     8581 tggcgcattc tcgaatgctg ttctgccggt ctcttcacgc cagttcagca atttaacatc
     8641 gtcttgcgcc cagtcagcca tcatgccgct agagaaagca ccagaaatga tgtcatccat
     8701 atgcttttgg aacagcggag ccatgatttc tttcaactgt tcagacagcg cataagcacg
     8761 cagtttagcc ggattggaca gacggtccat catcagcgta atcccgcctt gtttcagcgc
     8821 ttcggtaatg gtttcccaac cgaactgaat caatttctcg gcataagccg cgtcagtacc
     8881 ttcagaaacc agtttatcga aacacagcaa cgaaccggcc tgcaacatac cacacaggat
     8941 agtctgctca cccatcaggt cagattttac ttccgcaacg aaagaagact ccaacacacc
     9001 agcacgatga ccaccggttg ctgccgccca agccttggca atcgccatgc cttcgccttt
     9061 tggatcgttt tccgggtgaa ccgcgatcag tgtcggcaca ccaaaaccac gtttgtattc
     9121 ttcacgaact tcagtaccag ggcatttcgg cgctaccatc accacagtga tatctttacg
     9181 aacttgctca cccacttcaa cgatgttgaa gccatgagag taacccagtg ccgcgccatc
     9241 tttcatcagt ggctgaaccg cttgaaccac tgcggagtgc tgtttgtctg gtgtcaggtt
     9301 aaccaccaaa tcagcctgtg ggatcaaatc ttcgtaagta cctactttaa agccattttc
     9361 ggtcgctttg cgccatgaag cacgcttctc agcaatcgct tctttacgca gagcgtaagc
     9421 cacgtcaagg ccagaatcac gcatgttcaa gccttggttc aagccttgtg cgccacagcc
     9481 gacgatcacc acttttttac ctttcaggta gcttgcttca tcggcaaatt cgtcacgtgc
     9541 cataaagcga cacttaccta attgcgccaa ctgctgacgc aggttcaatg tgttgaaata
     9601 gttagccatg gtattactcc gttcgggttc tgttttgtgg gtgcagctat ttattttggt
     9661 tactgcaaac gaatattgtg tttgtgtagc taatgttgtg tgttgctgtt tttcacatcc
     9721 cctgtctggg ccggggatta tcttggattt actatatgac aggaaacaca ttgctgaaat
     9781 tgatatatta acaatgtgac gttgcagatt ctgcaataca gtttatttct tatgcaatac
     9841 aatagctctt ctcacctcag aggctgtctg ttatggattt acgtgacctg aaattgtttc
     9901 tgcatttggc tgaaagccgc cactttggcc gcacggctaa agcgacacac gtcagtccat
     9961 ccaccctgtc gcgccagatc cagcggctgg aagaaacgct cggacagccc ctgtttttac
    10021 gtgacaaccg cacggtgcaa ctgaccgatg ccggtacaca gctcaaggct tttgctcaac
    10081 agacattgct acagtaccag caactgcgcc atgcattagg tcagcacggg ccatcgctca
    10141 gtggtgaact gcgactattt tgttcggtca ccgccgccta tagccatttg ccccccattc
    10201 tggatcgctt tcgcgcacgc catccgttgg ttgaaatcaa actcactacc ggtgatgccg
    10261 ccgatgcggt ggataaagtg caatcgaatg aggctgatct cggtattgcg ggtcgccctg
    10321 aagtgctccc caccagcatt gcctttaccc agattggcga aattccactg gttctgattg
    10381 caccagcact gccttgtgca gtacgttcac aggtctcggt ggaacagccc gattgggcca
    10441 cggtcccctt tattttgcct gagcatggcc catcacgaaa acgcattgat ttgtggttcc
    10501 gccgtcaacg catcagtaac ccattgattt atgctacggt ttccggccat gaagcgattg
    10561 tatcaatggt agcattgggc tgcggtgtgg cactgatccc atcggtggtg gtggataaca
    10621 gcccggaacc ggtgcgcaac cgtatttcct tgctggatga tatttcgttg gtcgagccat
    10681 ttgagttggg ggtttgtgta cccaaaaaac ggctcaatga gccgttgatc gaagcatttt
    10741 ggggattgct gtagtttaca atcgagaagc gtaattcatg gcgggaacaa gattcctcag
    10801 ccccagattt aaatgattac caatagtcgc ctccacagga acaggagtgc tctctttggt
    10861 agggaaactg tttattgaat ttgtcagttg gcagatatcg ctgcgcaaat tgttggtaat
    10921 gtttacgttg ggataggtat caatcacgtt ataagtgatt ttaccagcag cattaaattt
    10981 ctgttcagcg cggtgcgtta tattattttt agcatcgaaa ctttgcttta ctaccacggt
    11041 ttcccccaat tgaactgctt ttttaaccgg atcatagcta aagcttttaa ccaccctctt
    11101 agtcatatta ttgttagaat caaagtgctc gatagcctta tttatcgtat tggtagttgc
    11161 atcataggtt cttatattga taatcttatt attcgcaggg ccaattcgtt ctgttgttac
    11221 aacctctcta actaccttat ctctattatg tgttgtttca atcgtcttac tcacacgcgc
    11281 ccctgagtac gattctattg agtattgcag tgggtctgaa cgacggctta gctgtgttgg
    11341 tggaatgtag tcaggtgccg atgatttaat tgatgcctta attgatgcta atgtttcact
    11401 catataaaaa ctccatatat tattcaaacc atgaaaaata atcattcaac aacatggtta
    11461 ttaactgcga tattattcat ctcaattaat aaatccacag atgatattac gctgcactaa
    11521 tactgaattt catttggaat gcttattttt gagaatatat aagaagatta aatataacta
    11581 agtagaaata aaaaactcag cacttattag cactgagttt tattactatt gataggtatt
    11641 cactgccact taatccagcc caaacttaac ccgctaaaaa gaacttaaac gccgggttgt
    11701 tagtttcatc atggcaatca tagcccagtg cggccaggtg ctcttcaaat tgcggctcag
    11761 aatctgacaa ctcaaaccct gccaataccc ggccaaaatc agtgccatgg ctacgatagt
    11821 ggaacaaaga aatgttccag tgcgtaccca aggtatgcaa gaacttcagc aatgcgcccg
    11881 gtgattcagg gaattcaaag ctgtacagcc gctcacgtaa tggcttcgaa ggacggcccc
    11941 ccaccatata acgcacatgc agcttggcca tctcgtcatc agatagatcc accacctgat
    12001 aatcttttgc ctgtagctcc gccaatatct ctgcccgctc ggcatagccg cgcgtcaaac
    12061 gtacccctac gaaaatgcag gcattgtcgg catcagcata acggtagtta aactcggtga
    12121 ctgaacgccc tcccagcaac tcgcagaaac gcagaaaact gccttttttc tcagggatag
    12181 tgacggccag caaagcttcg cgctgctcgc ccagctcaca acgttctgac acatagcgca
    12241 ggccgtggaa gttcacgtta gcaccggaca gcacatgggc cagacgttca cctttgatat
    12301 tatgctgctg gacatacttt ttcaggcccg ccagcgccaa agcaccagaa ggttcggcga
    12361 tggcacgcac atcctcaaat aaatctttta ctgccgcaca gatagcatca ctgtcgacgg
    12421 tgatcacttc gtccaaatac tcctggcaca ggcggaacgg ttcatcacca atgcgcttga
    12481 cggcgacacc ttcagcgaac aacccaacac gggctagatc aaccggcttg cccgcatcca
    12541 gtgcggcacg taagcaggct gaatcttctg cttcaacccc gatcacttta atctgcggca
    12601 tcagttgctt gataagcacc gccacaccag ccaccagccc accgccaccg accgggacaa
    12661 aaatccgatc aaggtgtgcg tcttgctgga gcaactccat cgccagcgtc ccctg
//
