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Overview
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1.19

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP060401.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1 | PpyS-KS | 173,317 | 194,363 |
Region 2 | phenazine | 253,724 | 274,200 | iodinin | Other:Phenazine | 45%
Region 3 | siderophore | 626,988 | 651,487 | putrebactin / avaroferrin | Other | 100%
Region 4 | NRPS | 991,382 | 1,074,261 | xenoamicin A / xenoamicin B | NRP:Cyclic depsipeptide | 25%
Region 5 | NRPS | 1,099,837 | 1,154,346 | xenematide | NRP | 100%
Region 6 | NRPS-like,NRPS | 1,275,494 | 1,314,984 | thanamycin | NRP:Beta-lactam | 27%
Region 7 | NRPS | 1,369,366 | 1,440,064 | odilorhabdins | NRP | 100%
Region 8 | NRPS | 1,497,306 | 1,545,591 | nematophin | NRP | 25%
Region 9 | NRPS | 1,577,405 | 1,632,782 | nematophin | NRP | 93%
Region 10 | NRPS,T1PKS,NRPS-like | 1,667,694 | 1,724,168 |
Region 11 | NRPS | 1,777,095 | 1,887,103 | xenoamicin A / xenoamicin B | NRP:Cyclic depsipeptide | 54%
Region 12 | T1PKS,NRPS-like,NRPS | 2,106,572 | 2,184,886 | xenocoumacin 1 / xenocoumacin II | NRP + Polyketide:Modular type I | 100%
Region 13 | NRPS-like,thiopeptide | 2,247,682 | 2,286,218 | O-antigen | Saccharide | 14%
Region 14 | NRPS-like | 2,333,726 | 2,376,434 |
Region 15 | betalactone | 2,501,900 | 2,527,756 | lipopolysaccharide | Saccharide:Lipopolysaccharide | 5%
Region 16 | butyrolactone | 2,728,474 | 2,739,268 | taxlllaid A | NRP | 6%
Region 17 | NRPS | 2,815,627 | 2,860,018 | tilivalline / 9-deoxy tilivalline / dihydroxy tilivalline / dehydro tilivalline / dihydroxy-dehydro tilivalline | NRP:Pyrrolobenzodiazepine | 47%
Region 18 | NRPS-like | 2,875,587 | 2,918,796 | safracin A / safracin B | NRP | 20%
Region 19 | nucleoside | 3,658,529 | 3,680,655 | berninamycin A | RiPP | 26%

NZ_CP060401.1 - Region 1 - PpyS-KS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 173,317 - 194,363 nt. (total: 21,047 nt) Show pHMM detection rules used
PpyS-KS: PpyS

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | PpyS-KS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000783.1 |  | 0.19 | Saccharide | O-antigen | Xanthomonas oryzae pv. oryzae
BGC0000780.1 |  | 0.17 | Saccharide | O&K-antigen | Vibrio parahaemolyticus
BGC0000772.1 |  | 0.17 | Saccharide | lipopolysaccharide | Brucella melitensis
BGC0000386.1 |  | 0.15 | NRP | malleobactin A, malleobactin B, malleobactin C, malleobactin D | Burkholderia thailandensis E264
BGC0000795.1 |  | 0.14 | Saccharide | S-layer glycan | Aneurinibacillus thermoaerophilus
BGC0001859.1 |  | 0.11 | Other (Phosphonate) | fosfomycin | Pseudomonas syringae
BGC0001133.1 |  | 0.09 | NRP | taxlllaid A | Xenorhabdus bovienii SS-2004
BGC0001285.1 |  | 0.08 | Other (Fatty acid) | pseudopyronine A, pseudopyronine B | Pseudomonas putida
BGC0000981.1 |  | 0.04 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 10E6
BGC0000103.1 |  | 0.04 | Polyketide | mycolactone B | Mycobacterium ulcerans Agy99

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000783.1 |  | 0.51 | Saccharide | O-antigen | Xanthomonas oryzae pv. oryzae
BGC0000780.1 |  | 0.49 | Saccharide | O&K-antigen | Vibrio parahaemolyticus
BGC0000772.1 |  | 0.48 | Saccharide | lipopolysaccharide | Brucella melitensis
BGC0000386.1 |  | 0.46 | NRP | malleobactin A, malleobactin B, malleobactin C, malleobactin D | Burkholderia thailandensis E264
BGC0000795.1 |  | 0.44 | Saccharide | S-layer glycan | Aneurinibacillus thermoaerophilus
BGC0001859.1 |  | 0.37 | Other (Phosphonate) | fosfomycin | Pseudomonas syringae
BGC0001133.1 |  | 0.34 | NRP | taxlllaid A | Xenorhabdus bovienii SS-2004
BGC0001285.1 |  | 0.31 | Other (Fatty acid) | pseudopyronine A, pseudopyronine B | Pseudomonas putida
BGC0000981.1 |  | 0.21 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 10E6
BGC0000103.1 |  | 0.20 | Polyketide | mycolactone B | Mycobacterium ulcerans Agy99

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP060401.1 - Region 2 - phenazine
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 253,724 - 274,200 nt. (total: 20,477 nt) Show pHMM detection rules used
phenazine: phzB

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | phenazine | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001868.1 |  | 0.34 | Other (Phenazine) | iodinin | Xenorhabdus szentirmaii DSM 16338
BGC0000780.1 |  | 0.33 | Saccharide | O&K-antigen | Vibrio parahaemolyticus
BGC0000936.1 |  | 0.22 | Other | pyocyanine | Pseudomonas aeruginosa PAO1
BGC0000662.1 |  | 0.20 | Terpene | grixazone | Streptomyces griseus subsp. griseus NBRC 13350
BGC0002002.1 |  | 0.17 | NRP | 1,6-phenazinedimethanol, fontizine A | Serratia fonticola
BGC0001850.1 |  | 0.16 | Other (Shikimate-derived) | diazaquinomycin A, diazaquinomycin E, diazaquinomycin F, diazaquinomycin G | Streptomyces sp. F001
BGC0000451.1 |  | 0.16 | NRP | turnerbactin | Teredinibacter turnerae T7901
BGC0000294.1 |  | 0.16 | NRP | acinetobactin | Acinetobacter baumannii
BGC0001302.1 |  | 0.15 | Other | lomofungin | Streptomyces lomondensis
BGC0001538.1 |  | 0.15 | NRP, Polyketide | caboxamycin | Streptomyces sp. NTK 937

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001868.1 |  | 0.67 | Other (Phenazine) | iodinin | Xenorhabdus szentirmaii DSM 16338
BGC0000780.1 |  | 0.67 | Saccharide | O&K-antigen | Vibrio parahaemolyticus
BGC0000936.1 |  | 0.55 | Other | pyocyanine | Pseudomonas aeruginosa PAO1
BGC0000662.1 |  | 0.53 | Terpene | grixazone | Streptomyces griseus subsp. griseus NBRC 13350
BGC0002002.1 |  | 0.48 | NRP | 1,6-phenazinedimethanol, fontizine A | Serratia fonticola
BGC0001850.1 |  | 0.47 | Other (Shikimate-derived) | diazaquinomycin A, diazaquinomycin E, diazaquinomycin F, diazaquinomycin G | Streptomyces sp. F001
BGC0000451.1 |  | 0.47 | NRP | turnerbactin | Teredinibacter turnerae T7901
BGC0000294.1 |  | 0.47 | NRP | acinetobactin | Acinetobacter baumannii
BGC0001302.1 |  | 0.45 | Other | lomofungin | Streptomyces lomondensis
BGC0001538.1 |  | 0.45 | NRP, Polyketide | caboxamycin | Streptomyces sp. NTK 937

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP060401.1 - Region 3 - siderophore
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 626,988 - 651,487 nt. (total: 24,500 nt) Show pHMM detection rules used
siderophore: IucA_IucC

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | siderophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001870.1 |  | 0.62 | Other | putrebactin, avaroferrin | Xenorhabdus budapestensis
BGC0001572.1 |  | 0.34 | Other | desferrioxamine E | Pantoea agglomerans
BGC0001478.1 |  | 0.33 | Other | desferrioxamine E | Streptomyces sp. ID38640
BGC0000941.1 |  | 0.29 | Other | desferrioxamin B | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001453.1 |  | 0.29 | Other | desferrioxamine | Streptomyces argillaceus
BGC0000940.1 |  | 0.29 | Other | desferrioxamin B, desferrioxamine E | Streptomyces coelicolor A3(2)
BGC0001531.1 |  | 0.23 | Other | bisucaberin B | Tenacibaculum mesophilum
BGC0000939.1 |  | 0.19 | Other | aerobactin | Grimontia hollisae
BGC0000943.1 |  | 0.19 | Other | staphylobactin | Staphylococcus aureus subsp. aureus NCTC 8325
BGC0001555.1 |  | 0.19 | RiPP | colicin V | Escherichia coli chi7122

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001870.1 |  | 0.85 | Other | putrebactin, avaroferrin | Xenorhabdus budapestensis
BGC0001572.1 |  | 0.68 | Other | desferrioxamine E | Pantoea agglomerans
BGC0001478.1 |  | 0.66 | Other | desferrioxamine E | Streptomyces sp. ID38640
BGC0000941.1 |  | 0.63 | Other | desferrioxamin B | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001453.1 |  | 0.62 | Other | desferrioxamine | Streptomyces argillaceus
BGC0000940.1 |  | 0.62 | Other | desferrioxamin B, desferrioxamine E | Streptomyces coelicolor A3(2)
BGC0001531.1 |  | 0.56 | Other | bisucaberin B | Tenacibaculum mesophilum
BGC0000939.1 |  | 0.51 | Other | aerobactin | Grimontia hollisae
BGC0000943.1 |  | 0.51 | Other | staphylobactin | Staphylococcus aureus subsp. aureus NCTC 8325
BGC0001555.1 |  | 0.51 | RiPP | colicin V | Escherichia coli chi7122

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP060401.1 - Region 4 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 991,382 - 1,074,261 nt. (total: 82,880 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001758.1 |  | 0.38 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0000389.1 |  | 0.38 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0001131.1 |  | 0.37 | NRP | ambactin | Xenorhabdus miraniensis
BGC0001844.1 |  | 0.36 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001833.1 |  | 0.36 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001135.1 |  | 0.35 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001615.1 |  | 0.35 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0001128.1 |  | 0.34 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000417.1 |  | 0.34 | NRP | rhodochelin | Rhodococcus jostii RHA1
BGC0000331.1 |  | 0.34 | NRP | cyanopeptin | Planktothrix agardhii NIVA-CYA 116

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001758.1 |  | 0.70 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0000389.1 |  | 0.70 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0001131.1 |  | 0.70 | NRP | ambactin | Xenorhabdus miraniensis
BGC0001844.1 |  | 0.69 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001833.1 |  | 0.69 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001135.1 |  | 0.68 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001615.1 |  | 0.68 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0001128.1 |  | 0.67 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000417.1 |  | 0.67 | NRP | rhodochelin | Rhodococcus jostii RHA1
BGC0000331.1 |  | 0.67 | NRP | cyanopeptin | Planktothrix agardhii NIVA-CYA 116

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 4, location 991381 - 1074261:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X - ala - X) + (gly) + (X - X - X) + (X - X - X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_932: X - ala - X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (510..912): X
  NRPSPredictor2: phe, trp, phg, tyr, bht
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aromatic
    Large clusters prediction:
      phe, trp, phg, tyr, bht
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAWlLGaVcK
    Nearest Stachelhaus code:
      leu
    Stachelhaus code match:
      70% (weak)
  AMP-binding (1598..1995): ala
  NRPSPredictor2: ala
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      gly, ala
    Single AA prediction:
      ala
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLYNNALTYK
    Nearest Stachelhaus code:
      ala
    Stachelhaus code match:
      100% (strong)
  AMP-binding (2670..3084): X
  NRPSPredictor2: orn, lys, arg
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      orn, lys, arg
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DiSnIGAVtK
    Nearest Stachelhaus code:
      trp
    Stachelhaus code match:
      70% (weak)
ctg1_946: gly
  Search NORINE for peptide: strict or relaxed
  AMP-binding (478..883): gly
  NRPSPredictor2: gly
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      gly, ala
    Single AA prediction:
      gly
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DILQiGLIWK
    Nearest Stachelhaus code:
      gly
    Stachelhaus code match:
      90% (moderate)
ctg1_947: X - X - X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (517..931): X
  NRPSPredictor2: hydrophilic
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DtsDIGsVtK
    Nearest Stachelhaus code:
      glu
    Stachelhaus code match:
      60% (weak)
  AMP-binding (1597..2011): X
  NRPSPredictor2: gly, ala, val, leu, ile, abu, iva
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DtsDIGsViK
    Nearest Stachelhaus code:
      glu
    Stachelhaus code match:
      60% (weak)
  AMP-binding (2702..3114): X
  NRPSPredictor2: gly, ala, val, leu, ile, abu, iva
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DtsDIGtViK
    Nearest Stachelhaus code:
      glu
    Stachelhaus code match:
      60% (weak)
ctg1_948: X - X - X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (511..925): X
  NRPSPredictor2: gly, ala, val, leu, ile, abu, iva
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DtsDIGsViK
    Nearest Stachelhaus code:
      glu
    Stachelhaus code match:
      60% (weak)
  AMP-binding (1610..2024): X
  NRPSPredictor2: gly, ala, val, leu, ile, abu, iva
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DtsDIGsViK
    Nearest Stachelhaus code:
      glu
    Stachelhaus code match:
      60% (weak)
  AMP-binding (2712..3126): X
  NRPSPredictor2: gly, ala, val, leu, ile, abu, iva
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DtsDIGsViK
    Nearest Stachelhaus code:
      glu
    Stachelhaus code match:
      60% (weak)

NZ_CP060401.1 - Region 5 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,099,837 - 1,154,346 nt. (total: 54,510 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001825.1 |  | 0.80 | NRP | xenematide | Xenorhabdus nematophila AN6/1
BGC0001824.1 |  | 0.30 | NRP | xefoampeptides A-G | Xenorhabdus beddingii
BGC0001132.1 |  | 0.30 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.1 |  | 0.29 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0000417.1 |  | 0.28 | NRP | rhodochelin | Rhodococcus jostii RHA1
BGC0001128.1 |  | 0.28 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001149.1 |  | 0.28 | NRP, Saccharide | brabantamide A | Pseudomonas sp. SHC52
BGC0001844.1 |  | 0.27 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001185.1 |  | 0.27 | NRP | bacillibactin | Bacillus velezensis FZB42
BGC0001131.1 |  | 0.27 | NRP | ambactin | Xenorhabdus miraniensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001825.1 |  | 0.93 | NRP | xenematide | Xenorhabdus nematophila AN6/1
BGC0001824.1 |  | 0.64 | NRP | xefoampeptides A-G | Xenorhabdus beddingii
BGC0001132.1 |  | 0.63 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.1 |  | 0.63 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0000417.1 |  | 0.62 | NRP | rhodochelin | Rhodococcus jostii RHA1
BGC0001128.1 |  | 0.62 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001149.1 |  | 0.61 | NRP, Saccharide | brabantamide A | Pseudomonas sp. SHC52
BGC0001844.1 |  | 0.61 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001185.1 |  | 0.60 | NRP | bacillibactin | Bacillus velezensis FZB42
BGC0001131.1 |  | 0.60 | NRP | ambactin | Xenorhabdus miraniensis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 5, location 1099836 - 1154346:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (thr - phe - D-phe - X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_1009: thr - phe - phe - X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (459..881): thr
  NRPSPredictor2: thr
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      thr
    Single AA prediction:
      thr
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DFWNIGMVHK
    Nearest Stachelhaus code:
      thr
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1529..1937): phe
  NRPSPredictor2: phe
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aromatic
    Large clusters prediction:
      phe, trp, phg, tyr, bht
    Small clusters prediction:
      phe, trp
    Single AA prediction:
      phe
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DgFaVAAVgK
    Nearest Stachelhaus code:
      phe
    Stachelhaus code match:
      70% (weak)
  AMP-binding (2580..2988): phe
  NRPSPredictor2: phe
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aromatic
    Large clusters prediction:
      phe, trp, phg, tyr, bht
    Small clusters prediction:
      phe, trp
    Single AA prediction:
      phe
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DgFaVAAVgK
    Nearest Stachelhaus code:
      phe
    Stachelhaus code match:
      70% (weak)
  AMP-binding (4089..4506): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      vDTvISfGDK
    Nearest Stachelhaus code:
      ala-b
    Stachelhaus code match:
      70% (weak)

NZ_CP060401.1 - Region 6 - NRPS,NRPS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,275,494 - 1,314,984 nt. (total: 39,491 nt) Show pHMM detection rules used
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS-like | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000427.1 |  |  | 0.75 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0000389.1 |  |  | 0.70 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0000375.1 |  |  | 0.69 | NRP | indigoidine | Streptomyces chromofuscus
BGC0001132.1 |  |  | 0.67 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001135.1 |  |  | 0.66 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001128.1 |  |  | 0.66 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001479.1 |  |  | 0.62 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0001641.1 |  |  | 0.60 | NRP | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000351.1 |  |  | 0.58 | NRP | exochelin | Mycolicibacterium smegmatis
BGC0000979.1 |  |  | 0.57 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 10E9

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000427.1 |  | 0.70 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0000389.1 |  | 0.68 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0000375.1 |  | 0.68 | NRP | indigoidine | Streptomyces chromofuscus
BGC0001132.1 |  | 0.67 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001135.1 |  | 0.66 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001128.1 |  | 0.66 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001479.1 |  | 0.64 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0001641.1 |  | 0.64 | NRP | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000351.1 |  | 0.62 | NRP | exochelin | Mycolicibacterium smegmatis
BGC0000979.1 |  | 0.62 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 10E9

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 6, location 1275493 - 1314984:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (thr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 7, location 1275493 - 1313056:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (thr)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_1131: thr
  Search NORINE for peptide: strict or relaxed
  AMP-binding (0..236): thr
  NRPSPredictor2: thr
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      thr
    Single AA prediction:
      thr
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DFWNIGMVHK
    Nearest Stachelhaus code:
      thr
    Stachelhaus code match:
      100% (strong)

NZ_CP060401.1 - Region 7 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,369,366 - 1,440,064 nt. (total: 70,699 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001716.1 |  | 1.00 | NRP | odilorhabdins | Xenorhabdus nematophila AN6/1
BGC0000389.1 |  | 0.43 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0001434.1 |  | 0.37 | NRP | nematophin | Xenorhabdus budapestensis
BGC0001698.1 |  | 0.37 | NRP | nevaltophin A, nevaltophin B, nevaltophin C, nevaltophin D | Xenorhabdus budapestensis
BGC0001050.1 |  | 0.37 | NRP, Polyketide | thalassospiramide A | Tistrella bauzanensis
BGC0001758.1 |  | 0.33 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001844.1 |  | 0.32 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001135.1 |  | 0.32 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001131.1 |  | 0.32 | NRP | ambactin | Xenorhabdus miraniensis
BGC0001873.1 |  | 0.31 | NRP | pyrrolizixenamide A | Xenorhabdus szentirmaii DSM 16338

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001716.1 |  | 1.00 | NRP | odilorhabdins | Xenorhabdus nematophila AN6/1
BGC0000389.1 |  | 0.74 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0001434.1 |  | 0.70 | NRP | nematophin | Xenorhabdus budapestensis
BGC0001698.1 |  | 0.70 | NRP | nevaltophin A, nevaltophin B, nevaltophin C, nevaltophin D | Xenorhabdus budapestensis
BGC0001050.1 |  | 0.69 | NRP, Polyketide | thalassospiramide A | Tistrella bauzanensis
BGC0001758.1 |  | 0.66 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001844.1 |  | 0.66 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001135.1 |  | 0.65 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001131.1 |  | 0.65 | NRP | ambactin | Xenorhabdus miraniensis
BGC0001873.1 |  | 0.65 | NRP | pyrrolizixenamide A | Xenorhabdus szentirmaii DSM 16338

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 8, location 1369365 - 1440064:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X - ala) + (gly - X - X) + (X) + (X - X - X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_1212: X - ala
  Search NORINE for peptide: strict or relaxed
  AMP-binding (488..891): X
  NRPSPredictor2: asp, asn, glu, gln, aad
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DiESIGtVtK
    Nearest Stachelhaus code:
      lys
    Stachelhaus code match:
      70% (weak)
  AMP-binding (1573..1986): ala
  NRPSPredictor2: ala
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      ala
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVWqMigdDK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      60% (weak)
ctg1_1213: gly - X - X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (542..938): gly
  NRPSPredictor2: gly
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      gly, ala
    Single AA prediction:
      gly
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DILQiGMvWK
    Nearest Stachelhaus code:
      gly
    Stachelhaus code match:
      80% (moderate)
  AMP-binding (1599..2001): X
  NRPSPredictor2: asp, asn, glu, gln, aad
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DMENsGavNK
    Nearest Stachelhaus code:
      orn
    Stachelhaus code match:
      70% (weak)
  AMP-binding (2674..3080): X
  NRPSPredictor2: pro, pip
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      pro, pip
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DmenvsHVVK
    Nearest Stachelhaus code:
      pro
    Stachelhaus code match:
      50% (weak)
ctg1_1214: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (547..943): X
  NRPSPredictor2: val, leu, ile, abu, iva
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DspVIAeVwK
    Nearest Stachelhaus code:
      pro
    Stachelhaus code match:
      60% (weak)
ctg1_1215: X - X - X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (530..935): X
  NRPSPredictor2: hydrophobic-aliphatic
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DiESIGtVlK
    Nearest Stachelhaus code:
      lys
    Stachelhaus code match:
      70% (weak)
  AMP-binding (1599..2007): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      orn, lys, arg
    Small clusters prediction:
      orn, horn
    Single AA prediction:
      orn
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DigDLGiiDK
    Nearest Stachelhaus code:
      gln
    Stachelhaus code match:
      60% (weak)
  AMP-binding (2665..3071): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    Predicted physicochemical class:
      N/A
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DiEsiGTiVK
    Nearest Stachelhaus code:
      lys-b
    Stachelhaus code match:
      60% (weak)

NZ_CP060401.1 - Region 8 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,497,306 - 1,545,591 nt. (total: 48,286 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000465.1 |  | 1.00 | NRP | xenortide A, xenortide B, xenortide C, xenortide D | Xenorhabdus nematophila ATCC 19061
BGC0000426.1 |  | 0.34 | NRP | sevadicin | Paenibacillus larvae
BGC0000389.1 |  | 0.32 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0000416.1 |  | 0.27 | NRP | rhabdopeptide 1, rhabdopeptide 2, rhabdopeptide 3, rhabdopeptide 4 | Xenorhabdus nematophila ATCC 19061
BGC0001434.1 |  | 0.26 | NRP | nematophin | Xenorhabdus budapestensis
BGC0001698.1 |  | 0.26 | NRP | nevaltophin A, nevaltophin B, nevaltophin C, nevaltophin D | Xenorhabdus budapestensis
BGC0000342.1 |  | 0.26 | NRP | enniatin | Fusarium equiseti
BGC0000313.1 |  | 0.26 | NRP | beauvericin | Beauveria bassiana
BGC0001399.1 |  | 0.25 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0000396.1 |  | 0.25 | NRP | nodularin | Nostoc sp. 73.1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000465.1 |  | 1.00 | NRP | xenortide A, xenortide B, xenortide C, xenortide D | Xenorhabdus nematophila ATCC 19061
BGC0000426.1 |  | 0.67 | NRP | sevadicin | Paenibacillus larvae
BGC0000389.1 |  | 0.65 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0000416.1 |  | 0.60 | NRP | rhabdopeptide 1, rhabdopeptide 2, rhabdopeptide 3, rhabdopeptide 4 | Xenorhabdus nematophila ATCC 19061
BGC0001434.1 |  | 0.60 | NRP | nematophin | Xenorhabdus budapestensis
BGC0001698.1 |  | 0.60 | NRP | nevaltophin A, nevaltophin B, nevaltophin C, nevaltophin D | Xenorhabdus budapestensis
BGC0000342.1 |  | 0.59 | NRP | enniatin | Fusarium equiseti
BGC0000313.1 |  | 0.59 | NRP | beauvericin | Beauveria bassiana
BGC0001399.1 |  | 0.59 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0000396.1 |  | 0.58 | NRP | nodularin | Nostoc sp. 73.1

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 9, location 1497305 - 1545591:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (NMe-phe) + (NMe-phe)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_1301: phe
  Search NORINE for peptide: strict or relaxed
  AMP-binding (334..729): phe
  NRPSPredictor2: phe
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aromatic
    Large clusters prediction:
      phe, trp, phg, tyr, bht
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DALlMGAVcK
    Nearest Stachelhaus code:
      phe
    Stachelhaus code match:
      80% (moderate)
ctg1_1302: phe
  Search NORINE for peptide: strict or relaxed
  AMP-binding (554..949): phe
  NRPSPredictor2: phe
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aromatic
    Large clusters prediction:
      phe, trp, phg, tyr, bht
    Small clusters prediction:
      phe, trp
    Single AA prediction:
      phe
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAFTVAgVCK
    Nearest Stachelhaus code:
      phe
    Stachelhaus code match:
      90% (moderate)

NZ_CP060401.1 - Region 9 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,577,405 - 1,632,782 nt. (total: 55,378 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000416.1 |  | 0.97 | NRP | rhabdopeptide 1, rhabdopeptide 2, rhabdopeptide 3, rhabdopeptide 4 | Xenorhabdus nematophila ATCC 19061
BGC0001692.1 |  | 0.85 | NRP | nematophin | Xenorhabdus nematophila ATCC 19061
BGC0001434.1 |  | 0.45 | NRP | nematophin | Xenorhabdus budapestensis
BGC0001698.1 |  | 0.45 | NRP | nevaltophin A, nevaltophin B, nevaltophin C, nevaltophin D | Xenorhabdus budapestensis
BGC0000465.1 |  | 0.38 | NRP | xenortide A, xenortide B, xenortide C, xenortide D | Xenorhabdus nematophila ATCC 19061
BGC0000427.1 |  | 0.35 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0000375.1 |  | 0.34 | NRP | indigoidine | Streptomyces chromofuscus
BGC0001249.1 |  | 0.33 | NRP | dimethylcoprogen | Alternaria alternata
BGC0000389.1 |  | 0.32 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0000900.1 |  | 0.31 | Other | ferrichrome | Aspergillus oryzae

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000416.1 |  | 0.99 | NRP | rhabdopeptide 1, rhabdopeptide 2, rhabdopeptide 3, rhabdopeptide 4 | Xenorhabdus nematophila ATCC 19061
BGC0001692.1 |  | 0.95 | NRP | nematophin | Xenorhabdus nematophila ATCC 19061
BGC0001434.1 |  | 0.75 | NRP | nematophin | Xenorhabdus budapestensis
BGC0001698.1 |  | 0.75 | NRP | nevaltophin A, nevaltophin B, nevaltophin C, nevaltophin D | Xenorhabdus budapestensis
BGC0000465.1 |  | 0.70 | NRP | xenortide A, xenortide B, xenortide C, xenortide D | Xenorhabdus nematophila ATCC 19061
BGC0000427.1 |  | 0.68 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0000375.1 |  | 0.67 | NRP | indigoidine | Streptomyces chromofuscus
BGC0001249.1 |  | 0.66 | NRP | dimethylcoprogen | Alternaria alternata
BGC0000389.1 |  | 0.65 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0000900.1 |  | 0.65 | Other | ferrichrome | Aspergillus oryzae

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 10, location 1577404 - 1632782:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (NMe-X) + (NMe-X) + (NMe-X) + (X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_1364: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (358..758): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    Predicted physicochemical class:
      N/A
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      vAimlGAsMK
    Nearest Stachelhaus code:
      phe
    Stachelhaus code match:
      50% (weak)
ctg1_1367: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (549..945): X
  NRPSPredictor2: phe, trp, phg, tyr, bht
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      phe, trp, phg, tyr, bht
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAlvLaVsiK
    Nearest Stachelhaus code:
      gln
    Stachelhaus code match:
      50% (weak)
ctg1_1368: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (545..941): X
  NRPSPredictor2: phe, trp, phg, tyr, bht
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      phe, trp, phg, tyr, bht
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAlvLaVsiK
    Nearest Stachelhaus code:
      gln
    Stachelhaus code match:
      50% (weak)
ctg1_1369: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (549..944): X
  NRPSPredictor2: phe, trp, phg, tyr, bht
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      phe, trp, phg, tyr, bht
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAlvLaVsiK
    Nearest Stachelhaus code:
      gln
    Stachelhaus code match:
      50% (weak)

NZ_CP060401.1 - Region 10 - NRPS,NRPS-like,T1PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,667,694 - 1,724,168 nt. (total: 56,475 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | NRPS-like | T1PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | --- | ---
BGC0001909.1 |  |  |  | 0.92 | Polyketide | strobilurin | Strobilurus tenacellus
BGC0000410.1 |  |  |  | 0.79 | NRP | pseudomonine | Pseudomonas fluorescens
BGC0000389.1 |  |  |  | 0.77 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0001399.1 |  |  |  | 0.76 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0001699.1 |  |  |  | 0.75 | Polyketide | nidulanin A | Aspergillus nidulans FGSC A4
BGC0001050.1 |  |  |  | 0.74 | NRP, Polyketide | thalassospiramide A | Tistrella bauzanensis
BGC0001187.1 |  |  |  | 0.69 | NRP, Polyketide | xenolozoyenone | Glarea lozoyensis
BGC0001609.1 |  |  |  | 0.68 | NRP | gliovirin | Trichoderma virens Gv29-8
BGC0001844.1 |  |  |  | 0.63 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0000949.1 |  |  |  | 0.63 | NRP | A-500359 A, A-500359 B | Streptomyces griseus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001909.1 |  | 0.64 | Polyketide | strobilurin | Strobilurus tenacellus
BGC0000410.1 |  | 0.61 | NRP | pseudomonine | Pseudomonas fluorescens
BGC0000389.1 |  | 0.59 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0001399.1 |  | 0.59 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0001699.1 |  | 0.58 | Polyketide | nidulanin A | Aspergillus nidulans FGSC A4
BGC0001050.1 |  | 0.58 | NRP, Polyketide | thalassospiramide A | Tistrella bauzanensis
BGC0001609.1 |  | 0.56 | NRP | gliovirin | Trichoderma virens Gv29-8
BGC0001187.1 |  | 0.56 | NRP, Polyketide | xenolozoyenone | Glarea lozoyensis
BGC0000949.1 |  | 0.54 | NRP | A-500359 A, A-500359 B | Streptomyces griseus
BGC0001844.1 |  | 0.54 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 11, location 1667693 - 1724168:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X) + (X - mal) + (asn)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 12, location 1667693 - 1718390:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X) + (X - mal) + (asn)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 13, location 1679709 - 1724168:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X) + (X - mal) + (asn)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_1426: asn
  Search NORINE for peptide: strict or relaxed
  AMP-binding (477..916): asn
  NRPSPredictor2: asn
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      asp, asn
    Single AA prediction:
      asn
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DATKVGEVGK
    Nearest Stachelhaus code:
      asn
    Stachelhaus code match:
      100% (strong)
ctg1_1430: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (1217..1656): X
  NRPSPredictor2: hydrophilic
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DiedLGAItK
    Nearest Stachelhaus code:
      bht
    Stachelhaus code match:
      60% (weak)
ctg1_1431: X - mal
  Search NORINE for peptide: strict or relaxed
  AMP-binding (46..445): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      sfFFfaGPcK
    Nearest Stachelhaus code:
      ala
    Stachelhaus code match:
      50% (weak)
  PKS_AT (1238..1539): mal
  ATSignature: Malonyl-CoA
  Top 3 matches:
    Malonyl-CoA: 83.3%
    inactive: 66.7%
    2-Rhyd-Malonyl-CoA: 62.5%
  minowa: Malonyl-CoA
  Prediction, score:
    Malonyl-CoA: 60.4
    inactive: 36.2
    Methoxymalonyl-CoA: 15.4
    Methylmalonyl-CoA: 11.8
    trans-1,2-CPDA: 0.0
    fatty_acid: 0.0
    Propionyl-CoA: 0.0
    Isobutyryl-CoA: 0.0
    Ethylmalonyl-CoA: 0.0
    CHC-CoA: 0.0
    Benzoyl-CoA: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
    2-Methylbutyryl-CoA: 0.0

NZ_CP060401.1 - Region 11 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,777,095 - 1,887,103 nt. (total: 110,009 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001132.1 |  | 0.83 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001128.1 |  | 0.49 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001641.1 |  | 0.45 | NRP | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.1 |  | 0.42 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001758.1 |  | 0.41 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001844.1 |  | 0.38 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0000426.1 |  | 0.37 | NRP | sevadicin | Paenibacillus larvae
BGC0001131.1 |  | 0.37 | NRP | ambactin | Xenorhabdus miraniensis
BGC0000389.1 |  | 0.36 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0001833.1 |  | 0.35 | NRP | icosalide A, icosalide B | Burkholderia gladioli

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001132.1 |  | 0.94 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001128.1 |  | 0.78 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001641.1 |  | 0.75 | NRP | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.1 |  | 0.73 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001758.1 |  | 0.72 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001844.1 |  | 0.70 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0000426.1 |  | 0.70 | NRP | sevadicin | Paenibacillus larvae
BGC0001131.1 |  | 0.69 | NRP | ambactin | Xenorhabdus miraniensis
BGC0000389.1 |  | 0.69 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0001833.1 |  | 0.68 | NRP | icosalide A, icosalide B | Burkholderia gladioli

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 14, location 1777094 - 1887103:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (val - X - ile - thr - val) + (val - X) + (X - ala - X - pro - val) + (val - phe - val - val)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_1526: val - X - ile - thr - val
  Search NORINE for peptide: strict or relaxed
  AMP-binding (495..906): val
  NRPSPredictor2: val
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      val
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAwWLGGTFK
    Nearest Stachelhaus code:
      val
    Stachelhaus code match:
      90% (moderate)
  AMP-binding (1566..1971): X
  NRPSPredictor2: phe, trp, phg, tyr, bht
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aromatic
    Large clusters prediction:
      phe, trp, phg, tyr, bht
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAWlLGaVcK
    Nearest Stachelhaus code:
      leu
    Stachelhaus code match:
      70% (weak)
  AMP-binding (2667..3078): ile
  NRPSPredictor2: ile
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAwFLGVTFK
    Nearest Stachelhaus code:
      ile
    Stachelhaus code match:
      90% (moderate)
  AMP-binding (3745..4160): thr
  NRPSPredictor2: thr
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      thr
    Single AA prediction:
      thr
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DFWNIGMVHK
    Nearest Stachelhaus code:
      thr
    Stachelhaus code match:
      100% (strong)
  AMP-binding (4855..5258): val
  NRPSPredictor2: val
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      val
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAwWLGGTFK
    Nearest Stachelhaus code:
      val
    Stachelhaus code match:
      90% (moderate)
ctg1_1527: val - X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (514..930): val
  NRPSPredictor2: val
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      val
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAwWLGGTFK
    Nearest Stachelhaus code:
      val
    Stachelhaus code match:
      90% (moderate)
  AMP-binding (1621..2029): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    Predicted physicochemical class:
      N/A
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAWlLGaVaK
    Nearest Stachelhaus code:
      leu
    Stachelhaus code match:
      70% (weak)
ctg1_1528: X - ala - X - pro - val
  Search NORINE for peptide: strict or relaxed
  AMP-binding (509..908): X
  NRPSPredictor2: phe, trp, phg, tyr, bht
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aromatic
    Large clusters prediction:
      phe, trp, phg, tyr, bht
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAWlLGaVcK
    Nearest Stachelhaus code:
      leu
    Stachelhaus code match:
      70% (weak)
  AMP-binding (1573..1991): ala
  NRPSPredictor2: ala
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      gly, ala
    Single AA prediction:
      ala
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLYNNALTYK
    Nearest Stachelhaus code:
      ala
    Stachelhaus code match:
      100% (strong)
  AMP-binding (2689..3108): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophobic-aromatic
    Large clusters prediction:
      phe, trp, phg, tyr, bht
    Small clusters prediction:
      tyr, bht
    Single AA prediction:
      tyr
  Stachelhaus prediction details:
    Stachelhaus sequence:
      vDTvISfGDK
    Nearest Stachelhaus code:
      ala-b
    Stachelhaus code match:
      70% (weak)
  AMP-binding (3768..4183): pro
  NRPSPredictor2: pro
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      pro, pip
    Small clusters prediction:
      pro
    Single AA prediction:
      pro
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVQFvAHvAK
    Nearest Stachelhaus code:
      pro
    Stachelhaus code match:
      80% (moderate)
  AMP-binding (4843..5246): val
  NRPSPredictor2: val
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      val
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAwWLGGTFK
    Nearest Stachelhaus code:
      val
    Stachelhaus code match:
      90% (moderate)
ctg1_1540: val - phe - val - val
  Search NORINE for peptide: strict or relaxed
  AMP-binding (64..463): val
  NRPSPredictor2: val
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      val
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAFWIGGTFK
    Nearest Stachelhaus code:
      val
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1140..1534): phe
  NRPSPredictor2: phe
  SVM prediction details:
    Predicted physicochemical class:
      N/A
    Large clusters prediction:
      phe, trp, phg, tyr, bht
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAWcIgAVCK
    Nearest Stachelhaus code:
      phe
    Stachelhaus code match:
      80% (moderate)
  AMP-binding (2191..2595): val
  NRPSPredictor2: val
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      val
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAFWIGGTFK
    Nearest Stachelhaus code:
      val
    Stachelhaus code match:
      100% (strong)
  AMP-binding (3271..3675): val
  NRPSPredictor2: val
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      val
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAFWIGGTFK
    Nearest Stachelhaus code:
      val
    Stachelhaus code match:
      100% (strong)

NZ_CP060401.1 - Region 12 - NRPS,NRPS-like,T1PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,106,572 - 2,184,886 nt. (total: 78,315 nt) Show pHMM detection rules used
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T1PKS | NRPS-like | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | --- | ---
BGC0001054.1 |  |  |  | 1.77 | NRP, Polyketide | xenocoumacin 1, xenocoumacin II | Xenorhabdus nematophila ATCC 19061
BGC0001132.1 |  |  |  | 0.73 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0000979.1 |  |  |  | 0.72 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 10E9
BGC0000980.1 |  |  |  | 0.72 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 22D11
BGC0001128.1 |  |  |  | 0.71 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.1 |  |  |  | 0.71 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001443.1 |  |  |  | 0.69 | NRP, Polyketide | matlystatin A | Actinomadura atramentaria DSM 43919
BGC0001050.1 |  |  |  | 0.68 | NRP, Polyketide | thalassospiramide A | Tistrella bauzanensis
BGC0001641.1 |  |  |  | 0.65 | NRP | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.1 |  |  |  | 0.65 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001054.1 |  | 0.99 | NRP, Polyketide | xenocoumacin 1, xenocoumacin II | Xenorhabdus nematophila ATCC 19061
BGC0001050.1 |  | 0.69 | NRP, Polyketide | thalassospiramide A | Tistrella bauzanensis
BGC0000979.1 |  | 0.69 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 10E9
BGC0000980.1 |  | 0.69 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 22D11
BGC0000427.1 |  | 0.65 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0000901.1 |  | 0.65 | Other | ferrichrome | Aspergillus niger
BGC0000900.1 |  | 0.65 | Other | ferrichrome | Aspergillus oryzae
BGC0001443.1 |  | 0.63 | NRP, Polyketide | matlystatin A | Actinomadura atramentaria DSM 43919
BGC0001160.1 |  | 0.63 | Polyketide | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0000457.1 |  | 0.62 | NRP | vicibactin | Rhizobium etli CFN 42

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 15, location 2106571 - 2184886:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (asn - X) + (ohmal - mal) + (ohmal) + (glu) + (ohmal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 16, location 2106571 - 2172941:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (asn - X) + (ohmal - mal) + (ohmal) + (glu) + (ohmal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 17, location 2141069 - 2184886:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (asn - X) + (ohmal - mal)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_1832: mal
  PKS_AT (534..817): mal
  ATSignature: Malonyl-CoA
  Top 3 matches:
    Malonyl-CoA: 87.5%
    inactive: 79.2%
    2-Rhyd-Malonyl-CoA: 58.3%
  minowa: Malonyl-CoA
  Prediction, score:
    Malonyl-CoA: 112.1
    inactive: 85.0
    Methoxymalonyl-CoA: 44.6
    Methylmalonyl-CoA: 41.3
    Propionyl-CoA: 22.8
    2-Methylbutyryl-CoA: 20.8
    Benzoyl-CoA: 15.1
    Isobutyryl-CoA: 13.7
    CHC-CoA: 13.1
    trans-1,2-CPDA: 0.0
    fatty_acid: 0.0
    Ethylmalonyl-CoA: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
ctg1_1833: glu
  Search NORINE for peptide: strict or relaxed
  AMP-binding (243..643): glu
  NRPSPredictor2: glu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      glu, gln
    Single AA prediction:
      glu
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAQDmGaVqK
    Nearest Stachelhaus code:
      gln
    Stachelhaus code match:
      70% (weak)
ctg1_1836: mal
  PKS_AT (523..808): mal
  ATSignature: Malonyl-CoA
  Top 3 matches:
    Malonyl-CoA: 79.2%
    inactive: 66.7%
    2-Rhyd-Malonyl-CoA: 58.3%
  minowa: Malonyl-CoA
  Prediction, score:
    Malonyl-CoA: 88.5
    Methoxymalonyl-CoA: 63.4
    inactive: 63.1
    Methylmalonyl-CoA: 40.4
    Propionyl-CoA: 16.0
    Isobutyryl-CoA: 14.5
    fatty_acid: 13.7
    2-Methylbutyryl-CoA: 3.5
    trans-1,2-CPDA: 0.0
    Ethylmalonyl-CoA: 0.0
    CHC-CoA: 0.0
    Benzoyl-CoA: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
ctg1_1838: mal - mal
  PKS_AT (1113..1407): mal
  ATSignature: Malonyl-CoA
  Top 3 matches:
    Malonyl-CoA: 83.3%
    inactive: 75.0%
  minowa: Malonyl-CoA
  Prediction, score:
    Malonyl-CoA: 125.5
    inactive: 104.1
    Methoxymalonyl-CoA: 47.5
    Methylmalonyl-CoA: 38.1
    Propionyl-CoA: 25.1
    Isobutyryl-CoA: 15.8
    fatty_acid: 10.6
    Ethylmalonyl-CoA: 10.6
    CHC-CoA: 9.1
    trans-1,2-CPDA: 0.0
    Benzoyl-CoA: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
    2-Methylbutyryl-CoA: 0.0
  PKS_AT (2608..2892): mal
  ATSignature: Malonyl-CoA
  Top 3 matches:
    Malonyl-CoA: 79.2%
    inactive: 70.8%
    2-Rhyd-Malonyl-CoA: 62.5%
  minowa: Malonyl-CoA
  Prediction, score:
    Malonyl-CoA: 128.1
    inactive: 88.0
    Methoxymalonyl-CoA: 62.7
    Methylmalonyl-CoA: 56.0
    Propionyl-CoA: 33.2
    Ethylmalonyl-CoA: 28.1
    Isobutyryl-CoA: 23.7
    fatty_acid: 18.5
    2-Methylbutyryl-CoA: 16.2
    CHC-CoA: 10.1
    Benzoyl-CoA: 9.4
    trans-1,2-CPDA: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
ctg1_1843: asn - X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (485..899): asn
  NRPSPredictor2: asn
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      asp, asn
    Single AA prediction:
      asn
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLTKIGEVGK
    Nearest Stachelhaus code:
      asn
    Stachelhaus code match:
      100% (strong)
  AMP-binding (2055..2444): X
  NRPSPredictor2: asp, asn
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      asp, asn
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DpenIGhVDK
    Nearest Stachelhaus code:
      glu
    Stachelhaus code match:
      60% (weak)

NZ_CP060401.1 - Region 13 - NRPS-like,thiopeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,247,682 - 2,286,218 nt. (total: 38,537 nt) Show pHMM detection rules used
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))
thiopeptide: ((YcaO or TIGR03882) and ((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or PF07366 or PF06968 or PF04055) or thiostrepton)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
Thiopeptides
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS-like | thiopeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001168.1 |  |  | 0.64 | NRP | livipeptin | Streptomyces lividans 1326
BGC0001516.1 |  |  | 0.55 | NRP | aspergillic acid | Aspergillus flavus NRRL3357
BGC0000781.1 |  |  | 0.40 | Saccharide | O-antigen | Pseudomonas aeruginosa
BGC0000427.1 |  |  | 0.37 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0001844.1 |  |  | 0.37 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001758.1 |  |  | 0.36 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001641.1 |  |  | 0.36 | NRP | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.1 |  |  | 0.36 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001825.1 |  |  | 0.36 | NRP | xenematide | Xenorhabdus nematophila AN6/1
BGC0001128.1 |  |  | 0.36 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001168.1 |  | 0.65 | NRP | livipeptin | Streptomyces lividans 1326
BGC0001516.1 |  | 0.65 | NRP | aspergillic acid | Aspergillus flavus NRRL3357
BGC0000784.1 |  | 0.58 | Saccharide | O-antigen | Pseudomonas aeruginosa
BGC0000427.1 |  | 0.54 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0000375.1 |  | 0.53 | NRP | indigoidine | Streptomyces chromofuscus
BGC0001844.1 |  | 0.50 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001758.1 |  | 0.50 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001641.1 |  | 0.50 | NRP | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.1 |  | 0.50 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001825.1 |  | 0.50 | NRP | xenematide | Xenorhabdus nematophila AN6/1

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Thiopeptide predictions
Lists the possible core peptides for each biosynthetic enzyme, including the predicted class. Each core peptide shows the leader and core peptide sequences, separated by a dash. Predicted tail sequences are also shown.
No core peptides found.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Thiopeptides
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 18, location 2247681 - 2286218:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_1938: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (30..426): X
  NRPSPredictor2: val, leu, ile, abu, iva
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DvFiLGCimK
    Nearest Stachelhaus code:
      leu
    Stachelhaus code match:
      60% (weak)

Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists its possible molecular weights and the scores for cleavage site prediction and RODEO. If relevant, other features, such as macrocycle and amidation, will also be listed.
No core peptides found.
NZ_CP060401.1 - Region 14 - NRPS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,333,726 - 2,376,434 nt. (total: 42,709 nt) Show pHMM detection rules used
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001168.1 |  | 0.32 | NRP | livipeptin | Streptomyces lividans 1326
BGC0001900.1 |  | 0.32 | NRP | fragin | Burkholderia cenocepacia H111
BGC0001516.1 |  | 0.32 | NRP | aspergillic acid | Aspergillus flavus NRRL3357
BGC0001599.1 |  | 0.27 | NRP | fragin | Burkholderia cenocepacia H111
BGC0001399.1 |  | 0.25 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0001120.1 |  | 0.22 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0000375.1 |  | 0.21 | NRP | indigoidine | Streptomyces chromofuscus
BGC0000427.1 |  | 0.21 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0001844.1 |  | 0.18 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001758.1 |  | 0.18 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001168.1 |  | 0.65 | NRP | livipeptin | Streptomyces lividans 1326
BGC0001900.1 |  | 0.65 | NRP | fragin | Burkholderia cenocepacia H111
BGC0001516.1 |  | 0.65 | NRP | aspergillic acid | Aspergillus flavus NRRL3357
BGC0001599.1 |  | 0.61 | NRP | fragin | Burkholderia cenocepacia H111
BGC0001399.1 |  | 0.59 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0001120.1 |  | 0.55 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0000375.1 |  | 0.54 | NRP | indigoidine | Streptomyces chromofuscus
BGC0000427.1 |  | 0.54 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0001844.1 |  | 0.50 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001758.1 |  | 0.50 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 20, location 2333725 - 2376434:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_2013: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (4..402): X
  NRPSPredictor2: gly, ala, val, leu, ile, abu, iva
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DiFALvAifK
    Nearest Stachelhaus code:
      haorn
    Stachelhaus code match:
      60% (weak)

NZ_CP060401.1 - Region 15 - betalactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,501,900 - 2,527,756 nt. (total: 25,857 nt) Show pHMM detection rules used
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | betalactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000783.1 |  | 0.22 | Saccharide | O-antigen | Xanthomonas oryzae pv. oryzae
BGC0001859.1 |  | 0.20 | Other (Phosphonate) | fosfomycin | Pseudomonas syringae
BGC0000886.1 |  | 0.18 | Other | allylmalonyl-CoA | Streptomyces tsukubensis
BGC0000904.1 |  | 0.15 | Other | FR-900098 | Streptomyces rubellomurinus
BGC0000896.1 |  | 0.15 | Other | cycloserine | Streptomyces lavendulae subsp. lavendulae
BGC0000774.1 |  | 0.15 | Saccharide | lipopolysaccharide | Xanthomonas campestris pv. campestris
BGC0001587.1 |  | 0.14 | Other | ethylenediaminesuccinic acid hydroxyarginine (EDHA) | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000815.1 |  | 0.14 | Alkaloid | loline | Epichloe uncinata
BGC0001128.1 |  | 0.14 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001150.1 |  | 0.14 | Polyketide | pamamycin-607 | Streptomyces alboniger

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000783.1 |  | 0.55 | Saccharide | O-antigen | Xanthomonas oryzae pv. oryzae
BGC0001859.1 |  | 0.52 | Other (Phosphonate) | fosfomycin | Pseudomonas syringae
BGC0000886.1 |  | 0.50 | Other | allylmalonyl-CoA | Streptomyces tsukubensis
BGC0000904.1 |  | 0.45 | Other | FR-900098 | Streptomyces rubellomurinus
BGC0000896.1 |  | 0.45 | Other | cycloserine | Streptomyces lavendulae subsp. lavendulae
BGC0000774.1 |  | 0.44 | Saccharide | lipopolysaccharide | Xanthomonas campestris pv. campestris
BGC0001587.1 |  | 0.44 | Other | ethylenediaminesuccinic acid hydroxyarginine (EDHA) | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000815.1 |  | 0.43 | Alkaloid | loline | Epichloe uncinata
BGC0001128.1 |  | 0.43 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001150.1 |  | 0.43 | Polyketide | pamamycin-607 | Streptomyces alboniger

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP060401.1 - Region 16 - butyrolactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,728,474 - 2,739,268 nt. (total: 10,795 nt) Show pHMM detection rules used
butyrolactone: AfsA

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | butyrolactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000867.1 |  | 0.19 | Other | polyhydroxyalkanoic acids | Ectothiorhodospira shaposhnikovii
BGC0000866.1 |  | 0.19 | Other | polyhydroxyalkanoate | Burkholderia sp. DSM 9242
BGC0001120.1 |  | 0.17 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0000795.1 |  | 0.14 | Saccharide | S-layer glycan | Aneurinibacillus thermoaerophilus
BGC0000914.1 |  | 0.08 | Other | methylenomycin A | Streptomyces coelicolor A3(2)
BGC0001590.1 |  | 0.07 | Polyketide | formicamycins A-M | Streptomyces sp. KY5
BGC0001133.1 |  | 0.07 | NRP | taxlllaid A | Xenorhabdus bovienii SS-2004
BGC0001771.1 |  | 0.07 | NRP | scleric acid | Streptomyces sclerotialus
BGC0000864.1 |  | 0.06 | Other | eicosapentaenoic acid-like compound | Moritella marina ATCC 15381
BGC0001692.1 |  | 0.05 | NRP | nematophin | Xenorhabdus nematophila ATCC 19061

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000867.1 |  | 0.51 | Other | polyhydroxyalkanoic acids | Ectothiorhodospira shaposhnikovii
BGC0000866.1 |  | 0.51 | Other | polyhydroxyalkanoate | Burkholderia sp. DSM 9242
BGC0001120.1 |  | 0.47 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0000795.1 |  | 0.43 | Saccharide | S-layer glycan | Aneurinibacillus thermoaerophilus
BGC0000914.1 |  | 0.30 | Other | methylenomycin A | Streptomyces coelicolor A3(2)
BGC0001590.1 |  | 0.29 | Polyketide | formicamycins A-M | Streptomyces sp. KY5
BGC0001133.1 |  | 0.29 | NRP | taxlllaid A | Xenorhabdus bovienii SS-2004
BGC0001771.1 |  | 0.27 | NRP | scleric acid | Streptomyces sclerotialus
BGC0000864.1 |  | 0.25 | Other | eicosapentaenoic acid-like compound | Moritella marina ATCC 15381
BGC0001692.1 |  | 0.24 | NRP | nematophin | Xenorhabdus nematophila ATCC 19061

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP060401.1 - Region 17 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,815,627 - 2,860,018 nt. (total: 44,392 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001637.1 |  | 0.33 | NRP | kleboxymycin | Klebsiella oxytoca
BGC0001527.1 |  | 0.31 | Other | basidioferrin | Gelatoporia subvermispora
BGC0001627.1 |  | 0.31 | NRP | isonitrile lipopeptides | Mycobacterium tuberculosis H37Rv
BGC0000389.1 |  | 0.29 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0000446.1 |  | 0.27 | NRP | tilivalline, 9-deoxy tilivalline, dihydroxy tilivalline, dehydro tilivalline, dihydroxy-dehydro tilivalline | Klebsiella oxytoca
BGC0001805.1 |  | 0.27 | NRP | tilivalline | Klebsiella oxytoca
BGC0000328.1 |  | 0.26 | NRP | coronatine | Pseudomonas savastanoi pv. glycinea
BGC0001497.1 |  | 0.26 | Polyketide | actinonin | Streptomyces sp.
BGC0001442.1 |  | 0.26 | NRP | actinonin | Streptomyces sp. strain ATCC 14903
BGC0000287.1 |  | 0.25 | NRP | L-2-amino-4-methoxy-trans-3-butenoic acid | Pseudomonas aeruginosa PAO1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001637.1 |  | 0.67 | NRP | kleboxymycin | Klebsiella oxytoca
BGC0001527.1 |  | 0.64 | Other | basidioferrin | Gelatoporia subvermispora
BGC0001627.1 |  | 0.64 | NRP | isonitrile lipopeptides | Mycobacterium tuberculosis H37Rv
BGC0000389.1 |  | 0.62 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0000446.1 |  | 0.61 | NRP | tilivalline, 9-deoxy tilivalline, dihydroxy tilivalline, dehydro tilivalline, dihydroxy-dehydro tilivalline | Klebsiella oxytoca
BGC0001805.1 |  | 0.61 | NRP | tilivalline | Klebsiella oxytoca
BGC0000328.1 |  | 0.60 | NRP | coronatine | Pseudomonas savastanoi pv. glycinea
BGC0001497.1 |  | 0.60 | Polyketide | actinonin | Streptomyces sp.
BGC0001442.1 |  | 0.60 | NRP | actinonin | Streptomyces sp. strain ATCC 14903
BGC0000287.1 |  | 0.58 | NRP | L-2-amino-4-methoxy-trans-3-butenoic acid | Pseudomonas aeruginosa PAO1

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 23, location 2815626 - 2860018:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X) + (X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_2462: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (475..874): X
  NRPSPredictor2: hydrophobic-aliphatic
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVQYytlVcK
    Nearest Stachelhaus code:
      pro
    Stachelhaus code match:
      60% (weak)
ctg1_2463: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (17..433): X
  NRPSPredictor2: val, leu, ile, abu, iva
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      aAnfIsGalK
    Nearest Stachelhaus code:
      phe
    Stachelhaus code match:
      40% (weak)

NZ_CP060401.1 - Region 18 - NRPS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,875,587 - 2,918,796 nt. (total: 43,210 nt) Show pHMM detection rules used
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001168.1 |  | 0.32 | NRP | livipeptin | Streptomyces lividans 1326
BGC0001900.1 |  | 0.32 | NRP | fragin | Burkholderia cenocepacia H111
BGC0001516.1 |  | 0.29 | NRP | aspergillic acid | Aspergillus flavus NRRL3357
BGC0001599.1 |  | 0.27 | NRP | fragin | Burkholderia cenocepacia H111
BGC0001399.1 |  | 0.26 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0000234.1 |  | 0.22 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000375.1 |  | 0.21 | NRP | indigoidine | Streptomyces chromofuscus
BGC0000427.1 |  | 0.21 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0000410.1 |  | 0.21 | NRP | pseudomonine | Pseudomonas fluorescens
BGC0001591.1 |  | 0.18 | Other | fatty acid enol ester | uncultured bacterium CSLC2

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001168.1 |  | 0.66 | NRP | livipeptin | Streptomyces lividans 1326
BGC0001900.1 |  | 0.65 | NRP | fragin | Burkholderia cenocepacia H111
BGC0001516.1 |  | 0.63 | NRP | aspergillic acid | Aspergillus flavus NRRL3357
BGC0001599.1 |  | 0.61 | NRP | fragin | Burkholderia cenocepacia H111
BGC0001399.1 |  | 0.59 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0000234.1 |  | 0.55 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000375.1 |  | 0.54 | NRP | indigoidine | Streptomyces chromofuscus
BGC0000427.1 |  | 0.54 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0000410.1 |  | 0.53 | NRP | pseudomonine | Pseudomonas fluorescens
BGC0001591.1 |  | 0.50 | Other | fatty acid enol ester | uncultured bacterium CSLC2

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 24, location 2875586 - 2918796:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (gly)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_2508: gly
  Search NORINE for peptide: strict or relaxed
  AMP-binding (68..457): gly
  NRPSPredictor2: gly
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      gly, ala
    Single AA prediction:
      gly
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DILQLGLIWK
    Nearest Stachelhaus code:
      gly
    Stachelhaus code match:
      100% (strong)

NZ_CP060401.1 - Region 19 - nucleoside
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,658,529 - 3,680,655 nt. (total: 22,127 nt) Show pHMM detection rules used
nucleoside: (LipM or LipV or LipU or ToyB or TunD or pur6 or pur10 or nikJ or nikO or truD)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | nucleoside | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000878.1 |  | 0.23 | Other | puromycin | Streptomyces alboniger
BGC0001947.1 |  | 0.16 | Saccharide | K53 capsular polysaccharide | Acinetobacter baumannii
BGC0000760.1 |  | 0.15 | Saccharide | emulsan | Acinetobacter venetianus RAG-1 = CIP 110063
BGC0001774.1 |  | 0.15 | Other | spicamycin | Streptomyces fimbriatus
BGC0000243.1 |  | 0.15 | Polyketide | macrotetrolide | Streptomyces griseus subsp. griseus
BGC0000249.1 |  | 0.14 | Polyketide | nogalamycin | Streptomyces nogalater
BGC0000761.1 |  | 0.13 | Saccharide | exopolysaccharide | Methylobacillus sp. 12S
BGC0001472.1 |  | 0.12 | RiPP | berninamycin A | Streptomyces bernensis
BGC0001138.1 |  | 0.11 | Other (Nucleoside) | a201a | Marinactinospora thermotolerans
BGC0001927.1 |  | 0.11 | Other | A-94964 | Streptomyces sp.

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000878.1 |  | 0.57 | Other | puromycin | Streptomyces alboniger
BGC0001947.1 |  | 0.47 | Saccharide | K53 capsular polysaccharide | Acinetobacter baumannii
BGC0000760.1 |  | 0.46 | Saccharide | emulsan | Acinetobacter venetianus RAG-1 = CIP 110063
BGC0001774.1 |  | 0.45 | Other | spicamycin | Streptomyces fimbriatus
BGC0000243.1 |  | 0.44 | Polyketide | macrotetrolide | Streptomyces griseus subsp. griseus
BGC0000249.1 |  | 0.44 | Polyketide | nogalamycin | Streptomyces nogalater
BGC0000761.1 |  | 0.42 | Saccharide | exopolysaccharide | Methylobacillus sp. 12S
BGC0001472.1 |  | 0.39 | RiPP | berninamycin A | Streptomyces bernensis
BGC0001138.1 |  | 0.37 | Other (Nucleoside) | a201a | Marinactinospora thermotolerans
BGC0001927.1 |  | 0.37 | Other | A-94964 | Streptomyces sp.

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names