LOCUS       NZ_CP045845.1          10624 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP045845.1 Kluyvera intermedia strain N2-1 chromosome, complete
            genome.
ACCESSION   NZ_CP045845
VERSION     NZ_CP045845.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 14:13:36
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 4631228
            Orig. end    :: 4641852
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10624
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[4636228:4636852](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5624)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10624
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10624
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="4"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(893..3682)
                     /locus_tag="ctg1_4225"
                     /transl_table=11
                     /translation="MVQIPENPLILIDGSSYLYRAYHAFPPLTNRAGEPTGAMYGVLNM
                     LRSLILQYQPTHAVVVFDAKGKTFRDELFEDYKSHRPPMPDDLRAQIEPLHTMVKAMGL
                     PLLAVAGVEADDVIGTLAREAEKMGRPVLISTGDKDMAQLVTPGITLINTMTNTILGPE
                     EVVTKYGVPPELIIDFLALMGDSSDNIPGVPGVGEKTAQALLQGLGGLDTLYGEPEKIA
                     GLTFRGAKTMAAKLEQNKDLAYLSYKLATIKTDVELELGCEQLLVSPPSADELLELFKK
                     YEFKRWITDVESGTWMQAKGAKPAAKPAKAAVATVEPEEESATVLSSENYVTILDEETL
                     VTWIDKLKNAPLFAFDTETDSLDNISANMVGLSFATEPGVAAYVPVSHDYLDAPDQISR
                     ERVLELLKPLLEDDSLLKVGQNLKFDRGILANYGVELRGIAFDTMLESYTLDSVAGRHD
                     MDSLSDRWLKHKTITFEEIAGKGKNQLTFNQIALEEAGRYAAEDADVTLQLHLKMWPKL
                     QQTEGPLRIFNEIEMPLVPVLSRIERNGVKINPTVLHAHSQEIAKRLVELEQKAYEIAG
                     EEFNLASPKQLQTILFEKQGIKPLKKTPGGAPSTSEEVLEELALDYPLPKVILEYRGLA
                     KLKSTYTDKLPLMINPKTGRVHTSYHQAVTATGRLSSTDPNLQNIPVRSEEGRRIRQAF
                     IAPEDYVIVSADYSQIELRIMAHLSRDEGLLKAFAEGQDIHRATAAEVFGMPLESVTGE
                     QRRSAKAINFGLIYGMSAFGLARQLNIPRKEAQKYMDLYFERYPGVLDYMERTRAQAKE
                     QGFVATLDGRRLYLPDIKSSNGARRAGAERAAINAPMQGTAADVIKRAMIAVDSWLEGE
                     KPRVRMIMQVHDELVFEVHKDDVDAVTKKVHELMENSTQLDVPLLVEVGSGENWDQAH"
     aSDomain        complement(896..3658)
                     /aSDomain="TIGR00593"
                     /aSTool="tigrfam"
                     /description="pola: DNA polymerase I"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_4225_0035"
                     /evalue="3.40E-288"
                     /identifier="TIGR00593"
                     /label="ctg1_4225"
                     /locus_tag="ctg1_4225"
                     /protein_end="929"
                     /protein_start="8"
                     /score="956.7"
                     /tool="antismash"
                     /translation="LILIDGSSYLYRAYHAFPPLTNRAGEPTGAMYGVLNMLRSLILQY
                     QPTHAVVVFDAKGKTFRDELFEDYKSHRPPMPDDLRAQIEPLHTMVKAMGLPLLAVAGV
                     EADDVIGTLAREAEKMGRPVLISTGDKDMAQLVTPGITLINTMTNTILGPEEVVTKYGV
                     PPELIIDFLALMGDSSDNIPGVPGVGEKTAQALLQGLGGLDTLYGEPEKIAGLTFRGAK
                     TMAAKLEQNKDLAYLSYKLATIKTDVELELGCEQLLVSPPSADELLELFKKYEFKRWIT
                     DVESGTWMQAKGAKPAAKPAKAAVATVEPEEESATVLSSENYVTILDEETLVTWIDKLK
                     NAPLFAFDTETDSLDNISANMVGLSFATEPGVAAYVPVSHDYLDAPDQISRERVLELLK
                     PLLEDDSLLKVGQNLKFDRGILANYGVELRGIAFDTMLESYTLDSVAGRHDMDSLSDRW
                     LKHKTITFEEIAGKGKNQLTFNQIALEEAGRYAAEDADVTLQLHLKMWPKLQQTEGPLR
                     IFNEIEMPLVPVLSRIERNGVKINPTVLHAHSQEIAKRLVELEQKAYEIAGEEFNLASP
                     KQLQTILFEKQGIKPLKKTPGGAPSTSEEVLEELALDYPLPKVILEYRGLAKLKSTYTD
                     KLPLMINPKTGRVHTSYHQAVTATGRLSSTDPNLQNIPVRSEEGRRIRQAFIAPEDYVI
                     VSADYSQIELRIMAHLSRDEGLLKAFAEGQDIHRATAAEVFGMPLESVTGEQRRSAKAI
                     NFGLIYGMSAFGLARQLNIPRKEAQKYMDLYFERYPGVLDYMERTRAQAKEQGFVATLD
                     GRRLYLPDIKSSNGARRAGAERAAINAPMQGTAADVIKRAMIAVDSWLEGEKPRVRMIM
                     QVHDELVFEVHKDDVDAVTKKVHELMENSTQLDVPLLVEVGSGENWDQAH"
     PFAM_domain     complement(905..2026)
                     /aSDomain="DNA_pol_A"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00476.22"
                     /description="DNA polymerase family A"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_4225_0124"
                     /evalue="4.60E-159"
                     /label="ctg1_4225"
                     /locus_tag="ctg1_4225"
                     /protein_end="926"
                     /protein_start="552"
                     /score="529.6"
                     /tool="antismash"
                     /translation="LHAHSQEIAKRLVELEQKAYEIAGEEFNLASPKQLQTILFEKQGI
                     KPLKKTPGGAPSTSEEVLEELALDYPLPKVILEYRGLAKLKSTYTDKLPLMINPKTGRV
                     HTSYHQAVTATGRLSSTDPNLQNIPVRSEEGRRIRQAFIAPEDYVIVSADYSQIELRIM
                     AHLSRDEGLLKAFAEGQDIHRATAAEVFGMPLESVTGEQRRSAKAINFGLIYGMSAFGL
                     ARQLNIPRKEAQKYMDLYFERYPGVLDYMERTRAQAKEQGFVATLDGRRLYLPDIKSSN
                     GARRAGAERAAINAPMQGTAADVIKRAMIAVDSWLEGEKPRVRMIMQVHDELVFEVHKD
                     DVDAVTKKVHELMENSTQLDVPLLVEVGSGENWD"
     PFAM_domain     complement(2129..2692)
                     /aSDomain="DNA_pol_A_exo1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01612.22"
                     /description="3'-5' exonuclease"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_4225_0123"
                     /evalue="3.80E-42"
                     /label="ctg1_4225"
                     /locus_tag="ctg1_4225"
                     /protein_end="518"
                     /protein_start="330"
                     /score="144.1"
                     /tool="antismash"
                     /translation="YVTILDEETLVTWIDKLKNAPLFAFDTETDSLDNISANMVGLSFA
                     TEPGVAAYVPVSHDYLDAPDQISRERVLELLKPLLEDDSLLKVGQNLKFDRGILANYGV
                     ELRGIAFDTMLESYTLDSVAGRHDMDSLSDRWLKHKTITFEEIAGKGKNQLTFNQIALE
                     EAGRYAAEDADVTLQLHLKMWPKLQ"
     PFAM_domain     complement(2870..3172)
                     /aSDomain="5_3_exonuc"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01367.22"
                     /description="5'-3' exonuclease, C-terminal SAM fold"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_4225_0122"
                     /evalue="8.10E-29"
                     /label="ctg1_4225"
                     /locus_tag="ctg1_4225"
                     /protein_end="271"
                     /protein_start="170"
                     /score="100.2"
                     /tool="antismash"
                     /translation="VPPELIIDFLALMGDSSDNIPGVPGVGEKTAQALLQGLGGLDTLY
                     GEPEKIAGLTFRGAKTMAAKLEQNKDLAYLSYKLATIKTDVELELGCEQLLVSPPS"
     PFAM_domain     complement(3173..3658)
                     /aSDomain="5_3_exonuc_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02739.18"
                     /description="5'-3' exonuclease, N-terminal resolvase-like
                     domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_4225_0121"
                     /evalue="1.00E-54"
                     /label="ctg1_4225"
                     /locus_tag="ctg1_4225"
                     /protein_end="170"
                     /protein_start="8"
                     /score="184.8"
                     /tool="antismash"
                     /translation="LILIDGSSYLYRAYHAFPPLTNRAGEPTGAMYGVLNMLRSLILQY
                     QPTHAVVVFDAKGKTFRDELFEDYKSHRPPMPDDLRAQIEPLHTMVKAMGLPLLAVAGV
                     EADDVIGTLAREAEKMGRPVLISTGDKDMAQLVTPGITLINTMTNTILGPEEVVTKYG"
     CDS             4078..4986
                     /locus_tag="ctg1_4226"
                     /transl_table=11
                     /translation="MSRLLAAITLPISIALTILLTILCSIPIILAGIVKLIFPIPVIWR
                     SVSVFCNFMMYCWCSGLAALLYFNPWLKWDIQGLETLNKKNWYLLICNHHSWADIVVLC
                     VIFRNHIPMNKYFLKQQLAWVPFMGLACWALDMPFMRRYSRSFLIRHPEHRGKDVETTR
                     RSCEKFRSHPTTIVNFVEGSRFTPEKRQQTRSPYKNLLPPKAAGIAMALNVLGSQFDKL
                     LDVTLCYPENDKTPFYDMLSGKLTRIVVTVNLRPVDPELYGDYVGDKSFKRRFQLWLNA
                     LWEEKDRQIDAIKAEYKNAGQ"
     PFAM_domain     4300..4764
                     /aSDomain="Acyltransferase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01553.23"
                     /description="Acyltransferase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_4226_0125"
                     /evalue="7.20E-14"
                     /label="ctg1_4226"
                     /locus_tag="ctg1_4226"
                     /protein_end="229"
                     /protein_start="74"
                     /score="51.6"
                     /tool="antismash"
                     /translation="DIQGLETLNKKNWYLLICNHHSWADIVVLCVIFRNHIPMNKYFLK
                     QQLAWVPFMGLACWALDMPFMRRYSRSFLIRHPEHRGKDVETTRRSCEKFRSHPTTIVN
                     FVEGSRFTPEKRQQTRSPYKNLLPPKAAGIAMALNVLGSQFDKLLDVTLCY"
     CDS             complement(5001..5624)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03651"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_4227"
                     /sec_met_domain="TIGR03651 (E-value: 3.6e-06, bitscore:
                     25.1, seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKVWLALAGMILAFSASAAQITEGKQYVTIDKPVAGEPQVLEFF
                     SFYCPHCYQFEEVLHVSDNVKKKLPEGVKMTKYHVEFLGPLGKDLTQAWAVAMALGVED
                     KVTVPMFEAVQKTQTVQTVADIRTVFINAGVKGEDYDAAWNSFVVKSMVAQQEKAAADL
                     QLQGVPAMFVNGKYQLNPQGMDTSNMDVFVAQYADTVKQLVEKK"
     PFAM_domain     complement(5037..5507)
                     /aSDomain="DSBA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01323.22"
                     /description="DSBA-like thioredoxin domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_4227_0126"
                     /evalue="4.00E-29"
                     /label="ctg1_4227"
                     /locus_tag="ctg1_4227"
                     /protein_end="196"
                     /protein_start="39"
                     /score="101.9"
                     /tool="antismash"
                     /translation="QVLEFFSFYCPHCYQFEEVLHVSDNVKKKLPEGVKMTKYHVEFLG
                     PLGKDLTQAWAVAMALGVEDKVTVPMFEAVQKTQTVQTVADIRTVFINAGVKGEDYDAA
                     WNSFVVKSMVAQQEKAAADLQLQGVPAMFVNGKYQLNPQGMDTSNMDVFVAQY"
     CDS             complement(5652..6638)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_4228"
                     /sec_met_domain="APH (E-value: 1.5e-40, bitscore: 137.6,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNDKAFTFQTLHPDTIIDALFEQGIRVDSGLTPLNSYENRVYQFQ
                     DEDRRRMVVKFYRPERWSAAQILEEHQFALELVQDDVPVAAPLAFNDKTLLTHDGFYFT
                     VFPSVGGRQFESDNLDQMEWVGRYLGRLHQTGRKSRFVARPDIGVKEYLIEPRAVFEHS
                     ALIPAGLKDRFLKATDDLIDAVMGQWHGRFNSLRLHGDCHAGNILWRDGPMFVDLDDAR
                     NGPAIQDLWMLLNGSLAERRMQLEMIVEAYEEFSSFDSDELALIEPLRAMRLVYYLAWI
                     IRRWDDPAFPKNFPWLTGEDFWHRQIATFIEQVKVLQEPPLQLTPMY"
     PFAM_domain     complement(5871..6545)
                     /aSDomain="APH"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01636.25"
                     /description="Phosphotransferase enzyme family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_4228_0127"
                     /evalue="4.30E-41"
                     /label="ctg1_4228"
                     /locus_tag="ctg1_4228"
                     /protein_end="256"
                     /protein_start="31"
                     /score="141.4"
                     /tool="antismash"
                     /translation="TPLNSYENRVYQFQDEDRRRMVVKFYRPERWSAAQILEEHQFALE
                     LVQDDVPVAAPLAFNDKTLLTHDGFYFTVFPSVGGRQFESDNLDQMEWVGRYLGRLHQT
                     GRKSRFVARPDIGVKEYLIEPRAVFEHSALIPAGLKDRFLKATDDLIDAVMGQWHGRFN
                     SLRLHGDCHAGNILWRDGPMFVDLDDARNGPAIQDLWMLLNGSLAERRMQLEMIVEAYE
                     EFS"
     CDS             complement(6714..6983)
                     /locus_tag="ctg1_4229"
                     /transl_table=11
                     /translation="MKCKRLNEVIELLQPAWQKEPELNLMQFLQKLAQESGYDGELADL
                     TDDILIYHLKMRDSAKDAVIPGIQKDYEEDFKTALLRARGVIKE"
     PFAM_domain     complement(6726..6983)
                     /aSDomain="DUF1040"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF06288.15"
                     /description="Protein of unknown function (DUF1040)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_4229_0128"
                     /evalue="8.10E-46"
                     /label="ctg1_4229"
                     /locus_tag="ctg1_4229"
                     /protein_end="86"
                     /protein_start="0"
                     /score="154.4"
                     /tool="antismash"
                     /translation="MKCKRLNEVIELLQPAWQKEPELNLMQFLQKLAQESGYDGELADL
                     TDDILIYHLKMRDSAKDAVIPGIQKDYEEDFKTALLRARGV"
     CDS             7053..7637
                     /locus_tag="ctg1_4230"
                     /transl_table=11
                     /translation="VNAKSQVTGVVLAGGKASRMGGQDKGLMLLDGKPLWQHVSDRLHP
                     QVSSVVISANRNLNTYQESGLPVISDTLSDFPGPLAGMLSVMQQLPDEWFLFCPCDTPF
                     IPVDLFTRLDIDRFQAPVVWVHDGDRDHPAVALAHRSLASKISDYLIRGDRRVMVFMRE
                     VGGHSVDFSDIKSAFRNINTLEDLQKNQGAK"
     aSDomain        7071..7616
                     /aSDomain="TIGR02665"
                     /aSTool="tigrfam"
                     /description="molyb_mobA: molybdenum cofactor
                     guanylyltransferase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_4230_0036"
                     /evalue="9.30E-68"
                     /identifier="TIGR02665"
                     /label="ctg1_4230"
                     /locus_tag="ctg1_4230"
                     /protein_end="188"
                     /protein_start="6"
                     /score="225.9"
                     /tool="antismash"
                     /translation="VTGVVLAGGKASRMGGQDKGLMLLDGKPLWQHVSDRLHPQVSSVV
                     ISANRNLNTYQESGLPVISDTLSDFPGPLAGMLSVMQQLPDEWFLFCPCDTPFIPVDLF
                     TRLDIDRFQAPVVWVHDGDRDHPAVALAHRSLASKISDYLIRGDRRVMVFMREVGGHSV
                     DFSDIKSAFRNINTLEDLQ"
     PFAM_domain     7077..7526
                     /aSDomain="NTP_transf_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12804.9"
                     /description="MobA-like NTP transferase domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_4230_0129"
                     /evalue="3.40E-30"
                     /label="ctg1_4230"
                     /locus_tag="ctg1_4230"
                     /protein_end="158"
                     /protein_start="8"
                     /score="105.6"
                     /tool="antismash"
                     /translation="GVVLAGGKASRMGGQDKGLMLLDGKPLWQHVSDRLHPQVSSVVIS
                     ANRNLNTYQESGLPVISDTLSDFPGPLAGMLSVMQQLPDEWFLFCPCDTPFIPVDLFTR
                     LDIDRFQAPVVWVHDGDRDHPAVALAHRSLASKISDYLIRGDRRVM"
     CDS             7634..8176
                     /locus_tag="ctg1_4231"
                     /transl_table=11
                     /translation="MIPLLAIAAWSGTGKTTLLKKLIPELCIRGIRPGLIKHTHHNMDV
                     DKPGKDSYELRKAGAAQTLVASQQRWALMTETPEEGELDLAWLVSRMDASRLDLVLVEG
                     FKHEAVAKILLFREATGHAIDELVIDEHTIAVASDITLDIDVPVLDLNDFEEIVEFIVG
                     WLGGAGGFGSAASPESA"
     PFAM_domain     7646..8050
                     /aSDomain="MobB"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03205.16"
                     /description="Molybdopterin guanine dinucleotide synthesis
                     protein B"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_4231_0130"
                     /evalue="1.20E-47"
                     /label="ctg1_4231"
                     /locus_tag="ctg1_4231"
                     /protein_end="139"
                     /protein_start="4"
                     /score="161.3"
                     /tool="antismash"
                     /translation="LAIAAWSGTGKTTLLKKLIPELCIRGIRPGLIKHTHHNMDVDKPG
                     KDSYELRKAGAAQTLVASQQRWALMTETPEEGELDLAWLVSRMDASRLDLVLVEGFKHE
                     AVAKILLFREATGHAIDELVIDEHTIAVASD"
     aSDomain        7646..8119
                     /aSDomain="TIGR00176"
                     /aSTool="tigrfam"
                     /description="mobB: molybdopterin-guanine dinucleotide
                     biosynthesis protein B"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_4231_0037"
                     /evalue="5.10E-48"
                     /identifier="TIGR00176"
                     /label="ctg1_4231"
                     /locus_tag="ctg1_4231"
                     /protein_end="162"
                     /protein_start="4"
                     /score="161.0"
                     /tool="antismash"
                     /translation="LAIAAWSGTGKTTLLKKLIPELCIRGIRPGLIKHTHHNMDVDKPG
                     KDSYELRKAGAAQTLVASQQRWALMTETPEEGELDLAWLVSRMDASRLDLVLVEGFKHE
                     AVAKILLFREATGHAIDELVIDEHTIAVASDITLDIDVPVLDLNDFEEIVEFIV"
ORIGIN
        1 atccagcgcc ctgaatacgc tgaccaacca gaaaggcctc gcacgtacct caaaaacgcc
       61 aggacgtacg cagcttatca acctgttcga agtcgtagaa ggcaagcgcc ttgtcgacct
      121 tccaggctat ggcttcgcac aagttccaga agagatgaag atcaaatggc aaaaggcgct
      181 aggtgaatac ctggaaaaac gtctgtgcct gaaaggatta gtcatactga tggatatccg
      241 tcatccgctg aaggatctcg accaacagat gatcgagtgg gcggtcgcca gtgaaatcca
      301 ggttttggta ctgttgacta aggcagataa gctggcaagc ggcgcacgta aagcgcagtt
      361 aaaccaggtg cgtgaagcag ttcttgcctt taatggggat gtgcaggttg aagcattttc
      421 ttcactgaaa aagctgggcg tggacaaact tcgccagaag ctcgatagct ggtataacga
      481 aattccaccg caggaagagc cagaaatcgc cgaagagtaa ttcccgccat aaccccggat
      541 agcggcgcct ggcgccctgt tccgggctcg atttatcccc tcgttcgacc taacacatat
      601 caaattgact gatgcgaaaa cttttctttc gcccaataaa aaacgcccca gtcattactg
      661 actggggcgg ctaaaatatt cagccaaatc cgattacgtg aagtaaaagg tctgaaagat
      721 agaacatctt acctctgtac cctacgagat taactctact cttttttaca gttcacagaa
      781 agcatttttt gtagtttttt ttcatatgtt acatagcgaa ttctaatgtt catcacaaaa
      841 ttagataagt tatgttgctt acttacataa accagagtta ttaatcgaac acttaatgcg
      901 cttgatccca gttttcacca ctgcccactt ccaccagcaa tggcacatcc agttgggtgc
      961 tgttttccat taattcatgc acctttttcg ttaccgcatc cacatcatct ttatgaactt
     1021 caaagactaa ttcatcgtgt acctgcatga tcatacgaac gcgcggtttt tcaccttcta
     1081 accagctatc gacggcaatc attgcccgct tgataacatc agcggcggta ccctgcattg
     1141 gggcattaat cgccgcacgc tcagcaccag cacgacgcgc gccattgctg gatttaatat
     1201 ccggcagata caagcgacga ccatccagcg tggcaacaaa gccctgctct ttcgcctgcg
     1261 cacgggtacg ttccatgtag tccagtacac caggatagcg ctcaaagtag aggtccatat
     1321 acttctgcgc ttctttacgc ggaatgttca gctgacgcgc cagcccaaat gcactcatgc
     1381 cgtagatcag accaaagttg attgcctttg cgctacgacg ctgttcgccg gtcacgctct
     1441 ccagcggcat accaaacact tcggcagcgg tcgcacggtg aatatcctga ccttctgcaa
     1501 acgccttcag caagccttca tcgcgagata aatgcgccat gatacgcagt tcaatttgcg
     1561 agtagtcggc agagacgatg acgtaatctt ccggcgcaat aaacgcctga cgaatacggc
     1621 gtccttcttc gctacgcacc ggaatatttt gcaggttagg atcggtcgaa gaaaggcgcc
     1681 cggttgccgt caccgcctgg tgataggagg tgtgtacgcg accggtcttc gggttaatca
     1741 tcagcggcag tttgtcggta taagtcgact tcagcttcgc cagcccgcga tattcaagga
     1801 tcactttcgg cagcggataa tccagcgcca gctcttccag cacctcttcc gacgtagacg
     1861 gcgcgccgcc cggggttttc ttcagcggct taataccctg cttttcaaac aagatagttt
     1921 gcagctgttt tggcgaagcg aggttaaatt cttcgccagc aatctcgtaa gctttctgct
     1981 ccagttcaac cagacgttta gcgatttcct gcgagtgcgc atgcaatacg gtcggattaa
     2041 ttttcacacc gttgcgttca attcgtgaca gtacgggcac cagcggcatt tctatctcat
     2101 tgaagatgcg tagtggtcct tccgtctgct gtagcttcgg ccacattttc agatgcagtt
     2161 gcagcgtgac atcggcatct tccgccgcgt agcgcccggc ttcctccagc gcaatctggt
     2221 taaaggtcag ctggtttttg cctttcccgg caatctcttc aaaagtgatg gttttatgct
     2281 tcagccagcg gtcggagagg ctgtccatat catggcgtcc ggccacgctg tccagcgtgt
     2341 aggattccag catggtatca aaagcaatgc cgcgcagttc gacgccatag ttagcaagaa
     2401 tgccgcgatc gaatttcagg ttctggccta ccttcagcag gctatcgtct tctagtagcg
     2461 gtttaagcag ctccaacacg cgttcacgag agatctgatc cggcgcatca agatagtcat
     2521 gggaaaccgg gacataagcg gcaacacccg gttcagtggc aaacgacaag ccgaccatgt
     2581 tagctgagat attatcgagg ctatccgttt ccgtatcgaa ggcgaacaat ggcgcatttt
     2641 ttaacttgtc gatccacgtc accaaggttt cttcatcaag aatggtaacg tagttttctg
     2701 atgataatac ggttgccgac tcttcttcag gctcaacggt cgcgacagcg gctttcgccg
     2761 gttttgctgc cggcttggcg cctttggcct gcatccaggt accggactca acatcagtta
     2821 tccagcgttt gaattcgtac ttcttaaaca gctccagcaa ctcatccgcc gatggaggtg
     2881 aaacaagcag ctgttcgcat cccagttcaa gctccacgtc ggttttaatg gtggcgagtt
     2941 tgtaggagag ataggccaga tctttattct gctcaagctt cgccgccatg gttttcgcgc
     3001 cacggaaggt cagcccagca attttttcag gttcaccata cagcgtatcc agaccaccta
     3061 aaccttgcag cagcgcttgt gccgttttct cgccaacacc cggtacgcct ggaatgttat
     3121 ccgaagagtc acccattagc gccaggaagt cgatgatcaa ctccggcggt acaccatatt
     3181 ttgtgaccac ttcttcaggg ccgaggatgg tattggtcat ggtgttaata agcgtgatgc
     3241 ccggcgtcac cagctgcgcc atatctttgt cgccggtgct aatcagcact gggcgcccca
     3301 ttttttccgc ttcacgtgcc aacgtcccga taacgtcgtc cgcttctacg cccgcgactg
     3361 ccagcagcgg cagtcccatc gctttcacca tcgtatgcag cggctcaatt tgcgcacgca
     3421 ggtcgtccgg catcggtggg cgatgagact tgtagtcttc aaacagttcg tcacggaagg
     3481 ttttcccctt cgcatcaaaa accacaaccg cgtgagtcgg ctgatattgc aggatcaagc
     3541 tgcgcagcat gttcaacaca ccatacatcg cgcctgtcgg ctcgcctgca cggttagtta
     3601 gcggtgggaa tgcgtgatat gcccggtaga gataagagga gccatcaatg aggatgagag
     3661 ggttttctgg gatctgaacc ataatttccg tgcctgttta tcagattatg ggtaaaggat
     3721 gccacagaca gcatgaaaac atgagttttt cgccaaaata aggcgaaaag atttagagat
     3781 cttcgcgatc gcgcgtaaaa caaaatgtgg ataactttgt gaataatttt attttaataa
     3841 taacaaatca tctttaacac agacttaaat ttaaaataat ccattacttt caatttgtta
     3901 taacaagatc gagccagtaa aattcgatct gatgataatt cacacaatgt ggatagacac
     3961 gctggttctt gttgtattcc tctaagaccc atcatttagt gcgttttctg gtaaaatcag
     4021 cgccttgtgc cttttatatg ggcactttat ataactaact atctgaataa acatactatg
     4081 tcgagattac tcgcggcgat aacattgccc ataagtatcg cacttaccat tttgctgacg
     4141 atattatgct ccatacccat catccttgcc gggatcgtta agctgatttt tcccatcccg
     4201 gtgatatggc gttcagtctc agtattttgt aatttcatga tgtactgctg gtgctctggg
     4261 ctggctgctt tgctgtactt taatccctgg ctcaagtggg acattcaggg gctggaaacg
     4321 ctcaataaaa aaaattggta cctgcttatc tgtaatcacc acagctgggc ggatatcgtg
     4381 gtgctttgtg tgattttccg taaccacatc ccgatgaata agtattttct caagcaacag
     4441 ttggcctggg taccctttat ggggctggca tgctgggcct tagatatgcc ttttatgcgc
     4501 cgctattccc gaagcttttt aattcgccat ccagagcatc gcggtaaaga tgttgaaaca
     4561 acccgccgct cctgtgagaa attccgctcg catccaacaa ccatcgttaa ctttgtagaa
     4621 ggttcacgct ttacccctga aaaacgccag caaacccgct caccgtataa aaacctgctt
     4681 ccgccgaaag ctgcgggcat tgccatggca ttaaacgtat taggctctca gtttgataag
     4741 ctgctcgatg tcacgctgtg ctatccggaa aatgataaga cgccattcta cgatatgctc
     4801 agtgggaaat tgacgcgcat cgttgttacc gtcaatttac gaccggtaga ccctgagcta
     4861 tacggggatt atgtcggtga taagagtttc aagcgacgct ttcagctatg gctgaatgca
     4921 ttgtgggaag agaaagacag gcagatagat gccatcaaag cagaatacaa aaacgccggt
     4981 cagtgaccgg cgttttcatt ttatttcttc tcaacaagct gtttaacggt atcagcatac
     5041 tgagcgacaa agacgtccat attgctggtg tccatgccct gcgggttcag ctggtattta
     5101 ccattaacga acatggctgg aacgccctgc agctgaagat cggctgcggc tttttcctgc
     5161 tgagcgacca tcgatttcac cacgaagcta ttccatgcag catcgtagtc ttcgcctttc
     5221 acacccgcgt tgataaagac agtgcggatg tcagcaacgg tttgaacggt ttgcgttttc
     5281 tgtacagctt caaacatcgg tacagtgacc ttgtcttcca cgcccagcgc cattgctacg
     5341 gcccacgctt gagtcagatc tttgcccaga gggcccagga actcaacgtg atatttagtc
     5401 atttttacgc cttctggaag ctttttcttc acgttgtcag aaacgtgcaa aacttcctcg
     5461 aactgatagc aatgtgggca gtagaaggag aagaactcca gcacctgcgg ctcacctgca
     5521 accggcttat cgatagtaac gtattgtttg ccttcggtga tctgagcagc agatgcactg
     5581 aatgccagaa tcatacctgc cagcgcaagc caaacctttt tcataactca ctctctcctg
     5641 actatgtcga attaatacat tggcgttagc tgtagagggg gttcttgtag aaccttcacc
     5701 tgctcaatga aagtagcaat ctgccgatgc cagaaatctt ccccggttaa ccagggaaaa
     5761 tttttcggaa atgcggggtc atcccagcgt ctgatgatcc aggccagata ataaaccaac
     5821 cgcattgcac gtaaaggctc aatcagcgcc aattcatctg aatcaaagct gctgaattct
     5881 tcataagcct ctacgatcat ttcaagttgc atgcgtcttt cggcaagaga gccgttaagt
     5941 agcatccaga gatcctgtat agcgggaccg tttcgcgcat catcaagatc gacaaacatg
     6001 gggccatcac gccagagaat attcccggca tggcagtcac cgtgcagacg cagcgaatta
     6061 aagcgcccgt gccactgccc cattaccgca tcaatcagat catctgtcgc tttcaggaaa
     6121 cggtctttta atccagcggg gatcagcgcc gagtgttcaa acacagcacg aggttcaata
     6181 aggtactctt tgacgccgat atccggacgc gctacgaagc gtgatttacg cccggtctga
     6241 tgcagacgtc ccaggtagcg tcccacccac tccatttgat ccagattatc ggattcaaac
     6301 tggcggccac ccacgcttgg aaatacggtg aagtaaaaac catcgtgagt taacagggtt
     6361 ttatcgttaa aggcgagggg ggcggcaacc ggcacatcat cctgaaccag ctccagcgca
     6421 aactgatgct cttcaagtat ttgtgcggct gaccagcgtt ccggacgata gaacttcacc
     6481 accatgcggc gacggtcttc atcctggaac tggtacaccc ggttctcata actatttaga
     6541 ggtgtgagac cagaatcaac ccggataccc tgctcaaaca gggcatcaat aatggtatcc
     6601 gggtgaagag tctggaatgt gaaagccttg tcgttcatcc tgacatccga taacgatacg
     6661 aatgagtcag gatatcattt cgcagcagtt tgagcggctc tgcttacaac cttttactct
     6721 ttaatcaccc cacgagcgcg gagtaatgca gttttgaagt cttcttcata atctttctga
     6781 ataccgggga tcaccgcatc ctttgccgag tcgcgcattt tcagatggta gatcagaata
     6841 tcatccgtta aatcggccaa ttcaccgtca taacctgact cctgcgccag tttctgcaaa
     6901 aattgcatta aattcagctc aggctccttc tgccaggctg gctggaggag ttcaataact
     6961 tcgttcagac gtttacattt catggtcatg ctccttacgc ttgataaaga tacggtagca
     7021 gggtaatccc tacaataaaa gaggcgataa cggtgaatgc aaagagccag gtcacgggcg
     7081 tggtattggc gggcggtaaa gccagcagaa tgggtgggca ggataaggga ttgatgctgc
     7141 tggatggtaa gccgctgtgg caacacgtgt ctgacaggct gcatccacag gtaagttcag
     7201 tggttattag cgcgaaccgg aatctgaata cctatcagga aagcggtcta ccggtcataa
     7261 gtgatacgtt gtcagacttt cctggtcctc tggccggtat gttgtcggtt atgcagcagt
     7321 tacctgatga gtggtttctg ttttgcccat gcgacactcc ttttattcca gtggatctgt
     7381 tcactcgttt agatattgat cgttttcagg cacctgtcgt ttgggttcat gacggcgaca
     7441 gggatcaccc agctgttgca ctggcgcatc gaagtctggc atcgaaaata tcagattacc
     7501 tgattcgtgg cgatcgacgc gttatggtat ttatgcgtga agttggcggt cattctgtag
     7561 attttagcga cataaagtca gcatttcgca acatcaatac attggaagat ttgcagaaaa
     7621 atcagggggc gaaatgatcc cgttattagc gattgcagcc tggagtggta cgggaaaaac
     7681 aacgctgttg aaaaaattga tccctgaact ctgcattcgc ggtattcgcc ctggattgat
     7741 taaacatact caccacaata tggatgtcga taaacccggt aaagatagct atgagctgcg
     7801 taaagcgggt gcggcgcaga cgttagtcgc cagccaacaa cgctgggcgc tgatgacgga
     7861 aacaccggaa gaaggtgaac tcgatctcgc ctggctggta agccgaatgg atgcatcaag
     7921 gctggatttg gtactggttg aagggtttaa acacgaggca gtagctaaga ttttactgtt
     7981 tcgagaggcg actggacatg cgattgatga gcttgttatt gatgaacata cgatcgcagt
     8041 ggccagcgat attacattag atattgatgt accagtgctg gatttgaacg atttcgagga
     8101 gattgtggaa tttattgtgg gctggttggg tggcgctgga ggatttgggt ccgctgcttc
     8161 cccagagtcg gcgtgaacgc ctcgtccggg cttccggacg gggctgttgt cgcccgggcg
     8221 aacgcagtga ccccgggatt ttatccgtgc tttcatttcg cacacacgca aaaaagccca
     8281 tccggcagga tgggcttctt cactatttga tgcctggcag ttccctactc tcgcatgggg
     8341 agaccccaca ctaccatcgg cgctacggcg tttcacttct gagttcggca tggggtcagg
     8401 tgggaccacc gcgctgttgc cgccaggcaa attctgttta tcaacacgca tctctgcatg
     8461 tcgatttaat ctgtctcaag ctgaatatcg tgtctcatca ccaacaaaac acctttggcg
     8521 ttgtaaggtt aagcctcacg gttcattagt actggttagc tcaacgtatc gctacgctta
     8581 cacacccagc ctatcaacgt cgtagtcttc aacgttcctt caggactctc aaggagtcag
     8641 ggagaactca tctcggggca agtttcgtgc ttagatgctt tcagcactta tcttttccgc
     8701 atttagctac cgggcaatgc cattggcatg acaacccgaa caccagtgat gcgtccactc
     8761 cggtcctctc gtactaggag cagcccccct caattctcca gcgcccacgg cagataggga
     8821 ccgaactgtc tcacgacgtt ctaaacccag ctcgcgtacc actttaaatg gcgaacagcc
     8881 atacccttgg gacctacttc agccccagga tgtgatgagc cgacatcgag gtgccaaaca
     8941 ccgccgtcga tatgaactct tgggcggtat cagcctgtta tccccggagt accttttatc
     9001 cgttgagcga tggcccttcc attcagaacc accggatcac tatgacctgc tttcgcacct
     9061 gctcgagccg tcactctcgc agtcaagcta gcttatgcca ttgcactaac ctcctgatgt
     9121 ccgaccagga ttagctaacc ttcgtgctcc tccgttactc tttaggagga gaccgcccca
     9181 gtcaaactac ccaccagaca ctgtccgcaa cccggattac gggtctacgt tagaacacca
     9241 gccattaaag ggtggtattt caaggttggc tccatgcaga ctggcgtcca cacttcaaag
     9301 cctcccacct atcctacaca tcaaggacca gtgttcagtg tcaagctata gtaaaggttc
     9361 acggggtctt tccgtcttgc cgcgggtaca ctgcatcttc acagcgagtt caatttcact
     9421 gagtctcggg tggagacagc ctggccatca ttacgccatt cgtgcaggtc ggaacttacc
     9481 cgacaaggaa tttcgctacc ttaggaccgt tatagttacg gccgccgttt accggggctt
     9541 cgatcaagag cttcgcctta cagctaaccc catcaattaa ccttccggca ccgggcaggc
     9601 gtcacaccgt atacgtccac tttcgtgttt gcacagtgct gtgtttttaa taaacagttg
     9661 cagccagctg gtatcttcga ctgatttcag ctccatgggt aaaccacttc acctacatat
     9721 cagcgtgcct tctcccgaag ttacggcacc attttgccta gttccttcac ccgagttctc
     9781 tcaagcgcct tggtattctc tacctgacca cctgtgtcgg tttggggtac gatttgatgt
     9841 tacctgatgc ttagaggctt ttcctggaag tgcggcattt gttacttcag caccgtagtg
     9901 cctcgtcatc acacctcagc gttaacagaa gtccggattt acctaaactt cccgcctaca
     9961 tgcttaaacc gggacaaccg tcgcccggct aacatagccc tctccgtccc cccttcgcag
    10021 taacaccaag tacaggaata ttaacctgtt tcccatcgac tacgcctttc ggcctcgcct
    10081 taggggtcga ctcaccctgc cccgattaac gttggacagg aacccttggt cttccggcgt
    10141 gcgggttttt cacccgcatt atcgttactt atgtcagcat tcgcacttct gatacctcca
    10201 gcacccctca caggacacct tcaacggctt acagaacgct cccctaccca acaacacata
    10261 gtgtcgctgc cgcagcttcg gtgcacagtt tagccccgtt acatcttccg cgcaggccga
    10321 ctcgaccagt gagctattac gctttcttta aatgatggct gcttctaagc caacatcctg
    10381 gctgtctgag ccttcccaca tcgtttccca cttaactgtg actttgggac cttagctggc
    10441 ggtctgggtt gtttccctct tcacgacgga cgttagcacc cgccgtgtgt ctcccgtgat
    10501 aacattcttc ggtattcgta gtttgcatcg ggttggtaag tcgggatgac cccctagccg
    10561 aaacagtgct ctacccccga agatgagttc acgaggcgct acctaaatag ctttcgggga
    10621 gaac
//
