LOCUS       NZ_CP029736.1          11821 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP029736.1 Providencia rettgeri strain AR_0082 chromosome,
            complete genome.
ACCESSION   NZ_CP029736
VERSION     NZ_CP029736.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 16:13:57
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 4220656
            Orig. end    :: 4232477
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11821
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[4225656:4227477](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6821)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..11821
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..11821
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="3"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             909..1151
                     /locus_tag="ctg1_3787"
                     /transl_table=11
                     /translation="MNFLYEVRLRYYIQPSFALAGMGTESDDEKSEEQRYYRAEIHLKE
                     GGQDYDVMGWAKEQIIHDILDQYEKHIHFLHLLGK"
     CDS             complement(1261..1674)
                     /locus_tag="ctg1_3788"
                     /transl_table=11
                     /translation="MNESFDELNHLLFGLPYNYEDKNNYDHQDWVIKTYFDRMYNDHRF
                     LDVVDHIVQKIGYSADGAYCHFACEYDGFLDDMIFKEGVFFAIGYPPEKDDEIVVSEET
                     CFYYVRLACEKYLKVHPEDLASVSNLLSKMQML"
     PFAM_domain     complement(1282..1590)
                     /aSDomain="CdiI_4"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF18624.3"
                     /description="CDI immunity protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3788_0065"
                     /evalue="3.60E-23"
                     /label="ctg1_3788"
                     /locus_tag="ctg1_3788"
                     /protein_end="131"
                     /protein_start="28"
                     /score="82.0"
                     /tool="antismash"
                     /translation="DWVIKTYFDRMYNDHRFLDVVDHIVQKIGYSADGAYCHFACEYDG
                     FLDDMIFKEGVFFAIGYPPEKDDEIVVSEETCFYYVRLACEKYLKVHPEDLASVSNLL"
     CDS             complement(1686..4619)
                     /locus_tag="ctg1_3789"
                     /transl_table=11
                     /translation="MKLAASEPVTNINALLTKTGNWASSGEINLTAGKSIEAHGIAFNS
                     GKSLTFNAGQDILLGLKAIKDVDNVFKTNRYPELRSQLIANGNITLNAARDIDLQSANL
                     QSTDKIIVLSGRDTKLTATAYSAIPNPNEDNQDVRYVTSTLSGDKGVTLASNGALTAQG
                     STIKSLNDITLSSGGNVRLESVKTNYRKQSGKTYEELYRQIGTEINSGKTLTILSEGSI
                     LFQASRLIAKGAMDIAAKGGYLYAQAMEESSYFEEYKKKCNRWTLCITKKEVRKTRSDK
                     TNKVTEFTAGGDINLYAKDDVTLEATKINTGKNAKITSQTGKVNFKAVKNSQFEQVITN
                     SNGFYITQRNKGYTSDKWILPSLHIGGKLTVDANKGITADVKTKEGQSFEQALAILSRT
                     PGYEWLGDVKNNKNINWAVVKDAYSQWDIKTESLNPVVGAVIAIAVAAATYGTSTAASV
                     GELASSTATSMGASATTASMASAAAQAGFASLVSQASVALVENKGNLSKTLSSLGKSDT
                     AKSIVTSMIIAGSLEGFDIALYGKVTDPAKVTLPKLSDGNWTQVAQRVVGQSAISSTIG
                     TAIQGGSFTDNFKTALLNSVAGQIQAEGANLIGDKFQYLYVDKQGNILGHAGKALSHAG
                     LAALSAEISGGNVKGAAIGALAAELAALSLDNKSKNNLEGNTQKIKVLGAIAGAIVTGE
                     SNGAHSAAGAAENVFLYNHYLHNFYGSAGDKYFGGAFSLEKALESDSTLTEQEKQKIRS
                     QYLKGDSKEDPIKAILETLPVSDTMMALMQAKDTKDYAAAVLTSLPMERAVVVLGKLAK
                     VTKVNNVFFPKRPIKTPEGISINIDLPIHLATMDKFTQRAGVSGAHNADAFYGAVREKG
                     LQIISETATGVKGITQIEYKIPTKDAAGKLTGNYKGNGAEPFKKTVYDPKVYSDQKILD
                     LGQQAAANGYKDAIVKGLQSYNAKAGGVTFRVYLDPKTKGVSNFHPQ"
     PFAM_domain     complement(1692..2069)
                     /aSDomain="EndoU_bacteria"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF14436.8"
                     /description="Bacterial EndoU nuclease"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3789_0068"
                     /evalue="4.90E-06"
                     /label="ctg1_3789"
                     /locus_tag="ctg1_3789"
                     /protein_end="976"
                     /protein_start="850"
                     /score="27.0"
                     /tool="antismash"
                     /translation="RAGVSGAHNADAFYGAVREKGLQIISETATGVKGITQIEYKIPTK
                     DAAGKLTGNYKGNGAEPFKKTVYDPKVYSDQKILDLGQQAAANGYKDAIVKGLQSYNAK
                     AGGVTFRVYLDPKTKGVSNFHP"
     PFAM_domain     complement(2655..3176)
                     /aSDomain="DUF637"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04830.15"
                     /description="Possible hemagglutinin (DUF637)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3789_0067"
                     /evalue="8.40E-48"
                     /label="ctg1_3789"
                     /locus_tag="ctg1_3789"
                     /protein_end="655"
                     /protein_start="481"
                     /score="162.4"
                     /tool="antismash"
                     /translation="AAQAGFASLVSQASVALVENKGNLSKTLSSLGKSDTAKSIVTSMI
                     IAGSLEGFDIALYGKVTDPAKVTLPKLSDGNWTQVAQRVVGQSAISSTIGTAIQGGSFT
                     DNFKTALLNSVAGQIQAEGANLIGDKFQYLYVDKQGNILGHAGKALSHAGLAALSAEIS
                     GGNVKGAAIGA"
     PFAM_domain     complement(4041..4220)
                     /aSDomain="Fil_haemagg_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13332.8"
                     /description="Hemagglutinin repeat"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3789_0066"
                     /evalue="3.20E-04"
                     /label="ctg1_3789"
                     /locus_tag="ctg1_3789"
                     /protein_end="193"
                     /protein_start="133"
                     /score="20.9"
                     /tool="antismash"
                     /translation="DNQDVRYVTSTLSGDKGVTLASNGALTAQGSTIKSLNDITLSSGG
                     NVRLESVKTNYRKQS"
     CDS             complement(4738..4998)
                     /locus_tag="ctg1_3790"
                     /transl_table=11
                     /translation="MELKNKITDYTESEFLKFLTIICNADTANEEEQIKLVTHFEKVTE
                     HPSGSDLIYYPEDGADDSPVGILKTIKEWRAKNGKPSFKKG"
     PFAM_domain     complement(4747..4992)
                     /aSDomain="Colicin_Pyocin"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01320.20"
                     /description="Colicin immunity protein / pyocin immunity
                     protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3790_0069"
                     /evalue="4.80E-38"
                     /label="ctg1_3790"
                     /locus_tag="ctg1_3790"
                     /protein_end="84"
                     /protein_start="2"
                     /score="129.2"
                     /tool="antismash"
                     /translation="LKNKITDYTESEFLKFLTIICNADTANEEEQIKLVTHFEKVTEHP
                     SGSDLIYYPEDGADDSPVGILKTIKEWRAKNGKPSFK"
     CDS             complement(5001..6821)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Cloacin"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_3791"
                     /sec_met_domain="Cloacin (E-value: 2e-10, bitscore: 38.5,
                     seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGVHASDGSGWSSENDPYGGNDNSGKGTGPEGNGDGGNSGGGGNG
                     SSVNFSKTPEKQAIASAMLMTIPSQIAIVEGTWGITINTTALTSPFARLAGLLESSLPM
                     AGRLTAVGALLTPTPIALDTMDPAFREHQQQLANLVANQKLQSQTYSLTALPVSIVTDM
                     PVKDISRQKTVPAKVVVEQVVSPEKNKVTPAMTKNPQQVNVVQAKKTGRPGVYSVEIAP
                     GKPALQIEMTDKKPSASFKTPSYDNVKPESVIPSVTSETYQGIVDFGGDHAPIYISISK
                     NPTTAQEKQLIEEANRDWRALYPAEAAELDWKQASSELSQADVDAQTAKRELDKTKSSP
                     EGGALTDVSKNPLQIKQSSQVISSVFGIEYIEKIDNQKALSYLLNRNPEDYVINILSIA
                     SVYGYETDDGSEPEVLIDDPEIYESIVERFTLAKERLLDAEKAIKEAERKLGIALEKKK
                     KAEAKEKKAKDKKEKEEKRKKPGTATGKGKKVGDKWLNDASKENGAPIPEQVANKLRGK
                     KFNSFDEFRKAIWNEISKFPELIKNLSKNNKTLVSKGYSPFARKKDQVGGRKVHELHHD
                     NPISEGGEVYDMDNLRVTTPKKHIDIHRGK"
     PFAM_domain     complement(5928..6809)
                     /aSDomain="Cloacin"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03515.16"
                     /description="Colicin-like bacteriocin tRNase domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3791_0070"
                     /evalue="7.40E-38"
                     /label="ctg1_3791"
                     /locus_tag="ctg1_3791"
                     /protein_end="298"
                     /protein_start="4"
                     /score="130.9"
                     /tool="antismash"
                     /translation="ASDGSGWSSENDPYGGNDNSGKGTGPEGNGDGGNSGGGGNGSSVN
                     FSKTPEKQAIASAMLMTIPSQIAIVEGTWGITINTTALTSPFARLAGLLESSLPMAGRL
                     TAVGALLTPTPIALDTMDPAFREHQQQLANLVANQKLQSQTYSLTALPVSIVTDMPVKD
                     ISRQKTVPAKVVVEQVVSPEKNKVTPAMTKNPQQVNVVQAKKTGRPGVYSVEIAPGKPA
                     LQIEMTDKKPSASFKTPSYDNVKPESVIPSVTSETYQGIVDFGGDHAPIYISISKNPTT
                     AQEKQLIEEANRD"
     CDS             7410..7652
                     /locus_tag="ctg1_3792"
                     /transl_table=11
                     /translation="MHFFYEVRLHYSIQPSFALASMGTESDDEKSEEQRYYRAEIHLKK
                     GGQDYDVMGWAKEQIIHDILDQYEKHIHFLHLLSK"
     CDS             complement(7860..8270)
                     /locus_tag="ctg1_3793"
                     /transl_table=11
                     /translation="VGNAILQALGLKVGFPDRQVIALCGDGGISMLMADILTLIQENIP
                     LKMVIFNNGTLDFVELEQKSEGLIRSYTELKNPDFAKLFEVAGIKGFTAKNSHDLESIV
                     EAFLEHDRPAVLDAYIPCVTSYYGQLISLSIM"
     PFAM_domain     complement(7920..8267)
                     /aSDomain="TPP_enzyme_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02775.23"
                     /description="Thiamine pyrophosphate enzyme, C-terminal TPP
                     binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3793_0071"
                     /evalue="2.70E-26"
                     /label="ctg1_3793"
                     /locus_tag="ctg1_3793"
                     /protein_end="117"
                     /protein_start="1"
                     /score="92.3"
                     /tool="antismash"
                     /translation="GNAILQALGLKVGFPDRQVIALCGDGGISMLMADILTLIQENIPL
                     KMVIFNNGTLDFVELEQKSEGLIRSYTELKNPDFAKLFEVAGIKGFTAKNSHDLESIVE
                     AFLEHDRPAVLD"
     CDS             complement(8221..9030)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 163.3;
                     E-value: 1.5e-49)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_3794"
                     /transl_table=11
                     /translation="VIVLPADISAAEITDISHLNPTYSKPPVVTPQIEDLNEIARLLNE
                     SKKITIYAGYGAKDARNEVISLAKKLKAPIAHTSRAKMYIEWDNPYNVGMTGTLGLYSG
                     YKAIKSCEIMLILGADFAWSSFYPEHANIIQIDINSSKLGLRHSIKKGVIGDVKYTVAE
                     LLKLVTEKEDSKFLNEMTTLHDKSVSEFNKKAISKDADLIHPQYLVSLLSKHAQDDAIF
                     TGDSGSPFAWALHGIKSNGRREFLSSLKTWNGGKCHTTGTGAESWIS"
     PFAM_domain     complement(8539..8922)
                     /aSDomain="TPP_enzyme_M"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00205.24"
                     /description="Thiamine pyrophosphate enzyme, central
                     domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3794_0072"
                     /evalue="8.70E-30"
                     /label="ctg1_3794"
                     /locus_tag="ctg1_3794"
                     /protein_end="164"
                     /protein_start="36"
                     /score="103.3"
                     /tool="antismash"
                     /translation="NEIARLLNESKKITIYAGYGAKDARNEVISLAKKLKAPIAHTSRA
                     KMYIEWDNPYNVGMTGTLGLYSGYKAIKSCEIMLILGADFAWSSFYPEHANIIQIDINS
                     SKLGLRHSIKKGVIGDVKYTVAEL"
     CDS             complement(9091..9492)
                     /locus_tag="ctg1_3795"
                     /transl_table=11
                     /translation="MKKKIAKVIVETLESYGVKNCYGISGDTLNLITNEIHKSTIRWVH
                     TRHEEVAAFAAGAEALFTGNLTVCAGSCGPESLHLINGVHESHRNGAPIIVLASQLTTN
                     RLYSVFPQQVDFTEVYKGCSVFCEQINRP"
     PFAM_domain     complement(9094..9483)
                     /aSDomain="TPP_enzyme_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02776.20"
                     /description="Thiamine pyrophosphate enzyme, N-terminal TPP
                     binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3795_0073"
                     /evalue="1.60E-27"
                     /label="ctg1_3795"
                     /locus_tag="ctg1_3795"
                     /protein_end="133"
                     /protein_start="3"
                     /score="96.3"
                     /tool="antismash"
                     /translation="KIAKVIVETLESYGVKNCYGISGDTLNLITNEIHKSTIRWVHTRH
                     EEVAAFAAGAEALFTGNLTVCAGSCGPESLHLINGVHESHRNGAPIIVLASQLTTNRLY
                     SVFPQQVDFTEVYKGCSVFCEQINRP"
     CDS             complement(9886..10338)
                     /gene_functions="regulatory (smcogs) SMCOG1135:MarR family
                     transcriptional regulator (Score: 72; E-value: 6.1e-22)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_3796"
                     /transl_table=11
                     /translation="MHESLTIALLQARETAMGFFRPILKSYNLTEQQWRIIRVLADKRS
                     IDFHELSVQTCILRPSLTGILTRMEREGLIFRLKPLNDQRKLYVSLTPAGQELYDKARQ
                     EVEEGYQKIELAFSPEKMQQLTALLDELIALESPDYSKMADRKKSA"
     aSDomain        complement(9940..10329)
                     /aSDomain="TIGR02337"
                     /aSTool="tigrfam"
                     /description="HpaR: homoprotocatechuate degradation operon
                     regulator, HpaR"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_3796_0024"
                     /evalue="2.70E-54"
                     /identifier="TIGR02337"
                     /label="ctg1_3796"
                     /locus_tag="ctg1_3796"
                     /protein_end="133"
                     /protein_start="3"
                     /score="180.5"
                     /tool="antismash"
                     /translation="SLTIALLQARETAMGFFRPILKSYNLTEQQWRIIRVLADKRSIDF
                     HELSVQTCILRPSLTGILTRMEREGLIFRLKPLNDQRKLYVSLTPAGQELYDKARQEVE
                     EGYQKIELAFSPEKMQQLTALLDELI"
     PFAM_domain     complement(10081..10254)
                     /aSDomain="MarR"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01047.24"
                     /description="MarR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3796_0074"
                     /evalue="1.20E-10"
                     /label="ctg1_3796"
                     /locus_tag="ctg1_3796"
                     /protein_end="86"
                     /protein_start="28"
                     /score="41.2"
                     /tool="antismash"
                     /translation="LTEQQWRIIRVLADKRSIDFHELSVQTCILRPSLTGILTRMEREG
                     LIFRLKPLNDQRK"
     CDS             10769..11398
                     /locus_tag="ctg1_3797"
                     /transl_table=11
                     /translation="MKGTVFAVALNHQSQLSHWLEAFQQAPYKTPPKTPVWFIKPRNTR
                     INSGEKILHPAGEEMQSGATLALVIGKNARKVSKTDAHQFIAGFALANEVSLPEDTFYR
                     PAIKAKCRDTFCPIGEMVATSLNNPVDIITLVNGKEVDRWSTKDLIRDASELVAALSDF
                     ATLKQGDVILLGTPQQRVTIKPGDEVVIQAEGFPSLKNTVVAAGGK"
     aSDomain        10775..11377
                     /aSDomain="TIGR02305"
                     /aSTool="tigrfam"
                     /description="HpaG-N-term: 4-hydroxyphenylacetate
                     degradation bifunctional isomerase/decarboxylase,
                     N-terminal subunit"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_3797_0025"
                     /evalue="3.80E-78"
                     /identifier="TIGR02305"
                     /label="ctg1_3797"
                     /locus_tag="ctg1_3797"
                     /protein_end="203"
                     /protein_start="2"
                     /score="259.6"
                     /tool="antismash"
                     /translation="GTVFAVALNHQSQLSHWLEAFQQAPYKTPPKTPVWFIKPRNTRIN
                     SGEKILHPAGEEMQSGATLALVIGKNARKVSKTDAHQFIAGFALANEVSLPEDTFYRPA
                     IKAKCRDTFCPIGEMVATSLNNPVDIITLVNGKEVDRWSTKDLIRDASELVAALSDFAT
                     LKQGDVILLGTPQQRVTIKPGDEVVIQAEGFPSLKNTV"
     PFAM_domain     10781..11380
                     /aSDomain="FAA_hydrolase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01557.20"
                     /description="Fumarylacetoacetate (FAA) hydrolase family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3797_0075"
                     /evalue="6.80E-40"
                     /label="ctg1_3797"
                     /locus_tag="ctg1_3797"
                     /protein_end="204"
                     /protein_start="4"
                     /score="137.3"
                     /tool="antismash"
                     /translation="VFAVALNHQSQLSHWLEAFQQAPYKTPPKTPVWFIKPRNTRINSG
                     EKILHPAGEEMQSGATLALVIGKNARKVSKTDAHQFIAGFALANEVSLPEDTFYRPAIK
                     AKCRDTFCPIGEMVATSLNNPVDIITLVNGKEVDRWSTKDLIRDASELVAALSDFATLK
                     QGDVILLGTPQQRVTIKPGDEVVIQAEGFPSLKNTVV"
ORIGIN
        1 tggcgcgcag taacacgttt cgcggcggct ttatctccct tagctgccgc catcatatcg
       61 agattgttct ctataattat ttgctggagt tgatgctctg tataattata tgtataaacc
      121 aattcagcag aattagcggc agaaaaagcg ccttccggct tatgggtaat taatgcccct
      181 gcaagtccac ctaagacttt agtgaattga gttttggctt cattaccttt gatagcatct
      241 tgtaccaatg caagttgtct ttcttgctca ttgagatatt taggctcaaa caatttactg
      301 ttcaatgtta ttgcagctaa ctctgccgct aacgcaccaa caactgcgcc tttgacatta
      361 gccccagata tttcggcact caatcctgcc aatgccatat ggctaagtgt ctttccagca
      421 tgaccgatga tttttccctg tttatctaca tataaatact ggaatttatc acctatcagg
      481 ttagcccctt cggcttgaat ttgccctgcc acactattga gtagggctgt tttaaagttg
      541 tccgtgaagc tcccaccttg aatcgctgtt ccgatggttg agctgatagc actttgccct
      601 accacacgct gcgcgacttg agtccaattc ccgtcactga gctttggtaa ggtcactttg
      661 gcgggatcag tgactttgcc atataacgca atatcaaacc cttcaagtga acccgcaata
      721 atcatactgg tcactattga ttttgcagta tcactttgcc ctaggctgga taaggttttt
      781 gacaggtttc ctttgttctc gactaacgcg acagacgctt gagaaacaag tgaggcaaac
      841 cccgaagtgc gaaatgcctg ctcgaatgac tgtccttctt tggttttgaa gtagacttag
      901 gcgacgatat gaacttttta tacgaagttc gcctccgtta ctatattcag ccctcttttg
      961 ccttagcggg tatgggcaca gaaagtgatg atgaaaagag tgaagaacaa cgctactacc
     1021 gcgctgaaat tcacttaaaa gaaggtgggc aagactacga tgtgatgggc tgggcaaaag
     1081 agcagatcat tcacgatatt cttgatcagt acgaaaaaca tattcacttt ttacatttat
     1141 tgggtaagta gtcccaaaaa agaaatatta cctaaaatgt gtcgataaaa attcacaggc
     1201 ggctaaaatt atagccgcct gtttttattc aattatctat taatacaata gaatcctatt
     1261 ttataacatt tgcatttttg ataataaatt acttacgcta gctaagtctt caggatgaac
     1321 ttttaaatat ttttcacaag ctaatctgac atagtagaag caagtttctt cactgacgac
     1381 tatttcatca tctttttctg gaggataacc tattgcaaaa aaaacaccct ctttaaaaat
     1441 catatcatct aaaaatccat catactcaca agcaaaatga caatatgcac catcagcact
     1501 atagcctatc ttttgaacta tgtggtctac aacatctaag aaacggtgat cattatacat
     1561 ccggtcaaaa taagttttaa tgacccaatc ttgatggtca taattgtttt tatcctcata
     1621 attataaggt aatccaaaca ataaatgatt taattcatca aaagactcat tcatataaat
     1681 tattcctatt gaggatgaaa attgctaaca cctttagttt tgggatctaa ataaactcta
     1741 aaggtaactc cacctgcttt agcgttataa gattgtaatc cttttactat agcatcctta
     1801 tatccattag cagctgcctg ttgccctaaa tctaatattt tttggtctga ataaaccttc
     1861 gggtcataaa ctgttttttt aaatggctcc gcaccattac ctttatagtt acctgttaat
     1921 tttcctgctg catcttttgt tggtatttta tattcaattt gggtgatacc tttcacgcct
     1981 gttgccgttt cactaataat ctgtaaacct ttttctctaa ctgcaccata aaacgcatct
     2041 gcattatggg ctccagaaac tcccgctctt tgagtaaact tatccatcgt cgctaaatgt
     2101 attggtaaat caatattgat acttatacct tcaggagttt taatcggtct ttttggaaag
     2161 aaaacattat taactttcgt aactttggct aatttaccca aaacaacaac agctctttcc
     2221 atcggtaatg aggttagtac tgccgctgca tagtctttgg tatctttagc ctgcattaat
     2281 gccatcatgg tatcagatac tggcaaagtt tctaaaatag cctttatagg atcttcttta
     2341 ctatcccctt ttaaatattg ggaccttatt ttttgttttt cctgctctgt caaagtacta
     2401 tcactttcaa gtgctttttc taacgaaaat gcgccaccaa aatacttatc gccagctgaa
     2461 ccatagaagt tatgcaaata atggttataa agaaatacat tctcagctgc acctgcagcg
     2521 ctgtgtgcgc cattcgactc accagttaca atagccccag ctatagctcc taaaacttta
     2581 attttctgtg tattaccttc taaattattt ttacttttgt tatcaagaga tagcgcagct
     2641 aattcagcgg ctaatgcgcc aattgcggca ccttttacat taccaccact aatttctgca
     2701 cttagcgccg ccaaccccgc atgacttaga gctttccctg catgccccag aatatttccc
     2761 tgtttatcta catataaata ctggaattta tcgcctatca ggttagcccc ttcggcttga
     2821 atttgccctg ccacactatt gagtagggct gttttaaagt tgtccgtgaa gctcccacct
     2881 tgaatcgctg ttccgatagt tgagctgata gcactttgcc ctaccacacg ctgcgcgact
     2941 tgagtccaat tcccgtcact gagctttggt aaggtcactt tggcgggatc agtgactttg
     3001 ccatataacg caatatcaaa cccttcaagt gaacccgcaa taatcatact ggtcactatt
     3061 gattttgcag tatcactttt ccctaggcta gataaggttt ttgacaggtt tcctttattc
     3121 tcaactaatg cgacagacgc ttgagaaaca agtgaggcaa accccgcctg tgccgcagca
     3181 gaagccattg acgctgtcgt cgctgaagcc cccatgcttg tggcagtcga gctcgcaagt
     3241 tcaccaacac tggcggctgt agaggttcca taagtagcag ccgctacagc aatggcaatc
     3301 acagcaccta cgactggatt aaggctttca gtttttatat cccactggct ataagcatct
     3361 tttacaacag cccaattgat gtttttgtta tttttaacgt ccccgagcca ctcatacccc
     3421 ggagtgcgac ttaatatggc tagcgcctgc tcgaatgact gtccttcttt ggttttgaca
     3481 tccgcagtga tccctttatt cgcatcaacc gtcaacttgc caccaatatg aaggctgggt
     3541 agaatccatt tatctgaggt atacccttta ttgcgctgtg taatataaaa cccgttagaa
     3601 tttgtaatca cctgttcaaa ttgcgagttt ttgacagcct taaaattcac cttaccggtt
     3661 tgactggtga ttttggcatt cttgcccgta ttaattttgg tggcttctaa ggtgacatca
     3721 tccttggcat ataggttaat atcaccacct gcggtaaatt cagtgacttt attggtttta
     3781 tcactgcgtg tttttctcac ttcctttttc gtgatacaaa gcgtccatct attgcatttc
     3841 tttttatact cttcgaagta actgctttcc tccatggctt gggcatagag atacccacct
     3901 tttgccgcaa tatccatcgc gcctttggca atgagacgag acgcttggaa aagaatgctc
     3961 ccctcagaca aaatggtcag cgttttacca ctgttaattt cagtgccaat ttggcgatat
     4021 aactcttcat atgttttccc tgactgtttt cgataattcg ttttaaccga ctctaaccgt
     4081 acatttcccc cgcttgagag tgtgatgtca tttagggatt tgattgtgct accttgtgcg
     4141 gtaagtgcgc cattggaggc cagcgtgacg cctttatcac cggaaagtgt cgaagtgaca
     4201 taacgtacat cttggttatc ttcgttgggg ttgggaatgg cagagtaagc ggtagccgtt
     4261 aatttagtat cacggccaga aagtacaata attttatctg tggattgaag gttagccgac
     4321 tgcaagtcaa tatcacgggc cgcatttaac gtaatattac cattcgcaat gagttgagag
     4381 cgcagctctg ggtagcgatt ggtcttgaat acattgtcga catctttaat cgcttttaag
     4441 cctaacaaaa tatcttggcc tgcattgaac gtcagtgatt ttccactgtt gaaggcaatg
     4501 ccatgcgctt caatactttt gcctgcggtg aggtttattt cccctgaact tgcccaattt
     4561 cctgttttcg taagtaacgc attgatattg gtgacaggtt ctgaagccgc gagtttcatt
     4621 aagttgagtt catcgcgacg aataacaatt ggtggataag catcaatgat tcatccttaa
     4681 gtcattgatg ctttatgttc agctattcca ttaatagtag ttcttaagta gtagttctta
     4741 gccttttttg aaactaggct taccattttt agcacgccat tctttgattg tttttaaaat
     4801 accaactgga gaatcatcag cgccatcctc tgggtagtaa ataagatcac ttccacttgg
     4861 atgctctgtt actttttcaa agtgagtcac aagcttaatt tgttcttcct catttgctgt
     4921 atctgcatta caaataattg ttaaaaactt taaaaattca gattctgtat aatcagtaat
     4981 tttatttttt agttccattc ttatttacct ctatggatat caatatgttt tttcggggtt
     5041 gtaactctta aattgtccat gtcatagact tctccccctt cactaattgg gttgtcatgg
     5101 tgcaactcat gtacctttct accaccaact tgatcttttt tcctagcaaa aggcgagtat
     5161 cctttagaga caagagtttt attattctta ctaagatttt taatcaattc tggaaatttt
     5221 gatatctcat tccagatggc cttcctgaac tcatcaaaac tgttgaattt cttacctcgt
     5281 aatttattag ctacttgctc aggaatagga gcaccatttt ctttactggc atcattaagc
     5341 catttatcgc caactttttt gccttttcct gtagcagtgc caggcttttt acgcttctct
     5401 tctttttctt ttttatcctt cgctttcttt tctttagctt cggctttttt ctttttctct
     5461 aaagctatgc ccagctttct ctctgcttct ttaattgctt tttcagcgtc taaaagtcgc
     5521 tcttttgcta atgtgaaacg ctctacaata gactcataaa tttccggatc atcaattaga
     5581 acttcaggtt cgctaccatc atcagtctca tatccatata cgctagcaat actcaaaatg
     5641 ttaataacat aatcttcagg attacgattg agtaaatatg acaatgcttt ttgattatca
     5701 attttttcaa tatattcaat accaaatacg ctagaaatta cctgacttga ctgtttaatt
     5761 tgtaaaggat ttttactcac atcagttaaa gcaccgcctt ccggagagct tttagtttta
     5821 tcgagttctc tttttgctgt ctgagcatct acatctgctt gtgataactc gctacttgct
     5881 tgcttccaat ctaattccgc agcttcagct ggatataaag cacgccaatc tcggttagct
     5941 tcctcaatta gttgtttttc ttgtgcagtc gttggattct tcgatattga aatataaatt
     6001 ggcgcatggt cgccaccaaa atcaacaatc ccctgatatg tctcagacgt tacactcgga
     6061 ataaccgatt ctggcttaac attgtcataa gacggtgttt taaacgatgc actcggcttt
     6121 ttatccgtca tttcaatctg taatgccggt ttacctggtg caatttcaac agaatataca
     6181 cctggtcgcc cagttttttt agcttgaaca acattgacct gttgcgggtt tttagtcatt
     6241 gcgggcgtaa ctttattctt ttctggcgaa acaacctgtt caaccacaac cttagccggc
     6301 actgtttttt gacgagaaat atctttaacg ggcatatctg tcacgatgct gacaggaaga
     6361 gccgttaatg aatatgtttg actctgtaat ttctgattag cgactaaatt ggctaattgt
     6421 tgctgatgtt cccgaaaagc agggtccatt gtatctaaag caataggggt aggtgtaagt
     6481 aaagcaccaa cggcagttaa acgaccagcc atcggtaagc tactctccaa taacccagcc
     6541 aaacgggcaa aaggcgaagt gagtgcagtc gtattaattg taatacccca cgttccctca
     6601 actatcgcta tttgggacgg aatcgtcatt aacatggctg aggcaatagc ttgtttttcc
     6661 ggcgttttgc tgaaattcac cgatgaacca ttccctccac cgcctgagtt accgccatcc
     6721 ccattacctt ccggaccagt gccttttccg ctgttatcat ttccaccgta cggatcattc
     6781 tcagaactcc atcctgaacc atctgaagca tgtacaccca taaaaatttc ctttttttat
     6841 taagaatccg tttcatggca ctgtataaat acacagttaa gttaaattaa atataaacct
     6901 aattcatgaa taagaaaaaa tactaatgaa tattattttt gtttgcatta ctttttacct
     6961 tcgctttcct gctccctcat ccactcttca tgaaataaat catcctgcag aaggtagcaa
     7021 ttgattttct gtgcagccat aaggcgaaat catgaataac ggtaaatata ataaacgcca
     7081 tataatttga ttatttgtca tgttgtttaa gtttttgtca ttaacagtca gttaatagta
     7141 atgtaactta ttctcattaa ctgtttttag ataaaaaata tccaccatga ataaaattta
     7201 atattttcat gtttaatgcg gtttttttta tgttgttttc attccattat ttcgattaat
     7261 tcttcattga agataaaaat aaatgttata tgccggcaat caatcgattg attttattga
     7321 tgaatatgtc atggaagtat tattcgcctc tgccgggttc acattgatgt ggatggccga
     7381 ataggtttca agtggactta ggcgacgata tgcacttttt ctatgaagtt cgcctccatt
     7441 actctattca accgtcattt gccttagcga gtatgggtac agaaagtgat gatgaaaaga
     7501 gtgaagaaca acgctactac cgcgctgaaa ttcacttaaa aaaaggtggg caagactacg
     7561 atgtgatggg ctgggcaaaa gagcagatca ttcacgatat tcttgatcag tacgaaaaac
     7621 atattcactt tttacatttg cttagtaaat aatttttaaa taagatactg agggataaat
     7681 tgaagccaat ccctcttgag caattgattt taaaaagtaa taaccaaagc gttagttatt
     7741 catccattgc atctattcaa atgggtattt atttcttgac gaaattatcc accagtaagt
     7801 caacaaattc tcctcgctgg tcagtcagca tcgctttagc ccatacagcg ccattcccat
     7861 cacattatcg atagtgatat gagctggcca taatagctcg taacgcatgg tatataagcg
     7921 tctagaaccg ctggcctatc atgctctaaa aaagcttcaa caatagactc taaatcatgg
     7981 gaattttttg ccgtaaatcc tttgatccca gcgacttcaa acagcttagc aaaatcagga
     8041 ttcttcaatt ctgtatagct tcttattagc ccttctgatt tttgttctaa ctcaacaaaa
     8101 tccaatgttc cattgttaaa tatgaccatt tttagtggta tattttcttg aattagcgtc
     8161 aaaatatccg ccattaacat agagataccg ccatccccac acagtgcaat cacttgtcta
     8221 tcaggaaatc caactttcag ccccagtgcc tgtagtatgg catttcccac cgttccatgt
     8281 ttttaagctt gataaaaatt cccgtcgtcc attcgactta attccatgta acgcccaagc
     8341 aaaaggtgag ccgctatccc ctgtaaaaat agcatcatcc tgcgcatgtt tactgagtaa
     8401 ggaaactaaa tattgagggt ggattaaatc agcatctttt gaaattgctt ttttattgaa
     8461 ttctgaaacc gatttatcat gtaatgtggt catttcatta agaaacttag aatcctcttt
     8521 ttcggtcacc aattttaaaa gctcagcgac agtgtattta acgtcaccaa ttacaccttt
     8581 cttaatcgaa tgacgtagac ctagtttact cgagttaata tcgatttgaa tgatattggc
     8641 atgctccgga taaaaacttg accatgcgaa gtcagcacct aaaatcagca taatttcaca
     8701 actttttatt gctttatatc cagaataaag tcccagagtt cccgtcatac caacgttata
     8761 gggattatcc cactcgatat acattttggc tcgagaagta tgtgcgattg gggctttcaa
     8821 ttttttcgca agactgatca cttcattcct tgcgtcttta gcaccatatc ctgcataaat
     8881 agtaattttt ttactttcat ttagcagtcg tgctatctca ttcaaatctt caatctgagg
     8941 tgtcactact ggtggtttag aataggtagg atttaagtgt gatatatctg ttatttccgc
     9001 tgcgctgata tccgccggca acacaatcac cgccgctcct cgcttagtta acgctgcatg
     9061 aatcgcttta acaagaatac gctttgcatc ttatggccga ttgatttgct cacaaaatac
     9121 agaacagcct ttatacactt ctgtaaaatc aacttgttgg ggaaaaaccg aatacagtct
     9181 atttgtcgtt agttggctcg caagaacaat tattggcgca ccatttcgat ggctttcatg
     9241 aacaccatta attaaatgga gactttcagg accacaagag ccagcacaga ccgttaaatt
     9301 cccagtaaat aaggcttcag cacccgcagc aaacgcagca acttcttcat ggcgcgtgtg
     9361 tacccatcta atagtactct tatggatttc attcgttatt aggtttagcg tatcccctga
     9421 aataccataa caatttttga ccccatagct ttctaatgtt tcaacaataa cctttgcaat
     9481 cttctttttc ataacactct ccttgattac ttttataaaa aagatgtttt ctaagcgtta
     9541 ctttgcgtgt tttattatta aaaattcgca gcatgacgat attaaataaa ttttatatta
     9601 aatatagaaa aataatatcg caaataatgt gatggataat atcgtgggat taacgttaat
     9661 gattgagtaa tacatgccta cagctctgat gaactcaaac tgaatagatt aaaggcggaa
     9721 tacaaagtat aggaaataca agtgactgtt tagtgacaat gacgatattg cccattgaaa
     9781 ataggtagaa gttacaacga ggatgaacac agaatagctc gggaaataga tagcactata
     9841 acccgaacaa gaggtaatca cgcataactc aattcagagg ttcacttatg cgcttttttt
     9901 acgatctgcc attttactat aatctggact ctctaaagcg attagctcat ccaacaacgc
     9961 agttaattgc tgcattttct ctggtgaaaa tgccagctct attttttgat agccttcttc
    10021 cacttcctgc cgtgctttgt catagagctc ttgccctgca ggtgtcaaag agacatataa
    10081 tttacgttgg tcattcaacg gttttaagcg gaaaattaaa ccttcgcgct ccatacgggt
    10141 taggatcccc gttaaacttg ggcgcagaat acaggtttga actgataatt catgaaaatc
    10201 aattgaacgc ttatcagcta aaactcgaat gatacgccat tgctgttcag tcaaattata
    10261 cgactttaat atcggccgga aaaaacccat tgcggtttct cttgcctgca ataatgcaat
    10321 tgtcaatgat tcatgcataa gattaaaact caccacttaa ttaacgttac ttaacccaat
    10381 tttggcattt tatggcagtt gccatttcgc tttgttggcc ctgtactttg atgaaatcac
    10441 ataccatagc tatgagcttt cacatcacca gtttgcctta tttaagagta gcacggtcaa
    10501 ataacaatct caaagaaaaa ccctaaaata ttaatgagta aataatttaa aaactcactt
    10561 ttaagttaat tttttgtaaa taaaaaaaaa attaaaaaat aataatttct tttataacat
    10621 taacttacaa aaagataact taattatgtt aatgagatca caattaaaat taacatttcc
    10681 ataaacctat tgctaatttc aaaattatac tttattaata tattaataat tactcgaaag
    10741 ttgaattctt ttcattaagg agttgtcaat gaaaggcact gtatttgccg ttgccctcaa
    10801 tcatcaaagc cagcttagcc actggcttga ggcattccag caagcccctt ataaaacccc
    10861 accaaaaacc ccagtgtggt ttattaagcc gcgtaatacg cgtatcaatt caggcgagaa
    10921 aattttgcat cccgctggtg aagaaatgca aagtggcgct acgcttgctt tggtgatcgg
    10981 taaaaatgca cgtaaagtca gtaagacaga tgcacatcag tttattgctg ggtttgcgct
    11041 ggcaaatgaa gtgagcttgc cagaagacac cttctatcgc cctgccatta aagcaaaatg
    11101 ccgcgacacg ttttgtccaa ttggtgaaat ggttgcaact tcgctaaata atcctgtcga
    11161 tatcatcacc ctagtaaatg gtaaagaagt ggatcgctgg tcaacaaaag atctgatccg
    11221 tgatgcgagt gagttagttg ctgcattaag tgacttcgcc accttaaagc aaggggatgt
    11281 gatcctgctc ggcacaccac aacaacgtgt caccatcaaa cccggtgacg aagtggttat
    11341 tcaagcggaa ggctttccta gcctgaaaaa taccgttgtg gcagcaggag gaaaataatg
    11401 tctacgatta caaaacacgc aaaaatcctt tttaaaggca ctgaatattc cgtcaccgtc
    11461 ggtgataacg aagccattac gttacctaac ggggacgtga ttgcgggtga ttctcctgat
    11521 gttgaatggt tacctcctgc gcaaggaacc ttgtttgccc taggcctgaa ctatgccgac
    11581 cacgctgccg aattagaatt taagccacct gaagagcctt taattttctt aaaagcagaa
    11641 agcagcttaa cgggtcatcg ccaagtttct gttcgtcctg ataatgtgga atatatgcat
    11701 tatgagtctg aattagtggt ggtgattggc aaaacagctc acaaggtttc aagagaagat
    11761 gccatggact atgtcgcagg ttacaccgtg tgtaatgact atgcgatccg tgactattta
    11821 g
//
