GCF_000069965.1_ASM6996v1_genomic - 5 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NC_010554.1

Region	Type	From	To
Region 1.1	siderophore	270,591	282,471
Region 1.2	thiopeptide	759,220	785,699
Region 1.3	betalactone	2,236,231	2,261,955
Region 1.4	NRPS,T1PKS	2,814,947	2,870,279
Region 1.5	ladderane	3,168,388	3,210,949

Region	Type	From	To	Similarity
Region 1.1	siderophore	270,591	282,471
Region 1.2	thiopeptide	759,220	785,699
Region 1.3	betalactone	2,236,231	2,261,955
Region 1.4	NRPS,T1PKS	2,814,947	2,870,279
Region 1.5	ladderane	3,168,388	3,210,949

No secondary metabolite regions were found in these records:: NC_010555.1

Compact view

NC_010554.1 - Region 1 - siderophore

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Location: 270,591 - 282,471 nt. (total: 11,881 nt) Show pHMM detection rules used

siderophore: IucA_IucC

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001498.1	0.22	Other	aerobactin	Xenorhabdus szentirmaii DSM 16338
BGC0001408.1	0.19	Other	xanthoferrin	Xanthomonas oryzae pv. oryzae KACC 10331
BGC0000939.1	0.16	Other	aerobactin	Grimontia hollisae
BGC0001587.1	0.16	Other	ethylenediaminesuccinic acid hydroxyarginine (EDHA)	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000504.1	0.16	RiPP	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000592.1	0.16	RiPP	microviridin B	Microcystis aeruginosa NIES-298
BGC0001576.1	0.16	RiPP	divamide A	Prochloron didemni
BGC0001870.1	0.16	Other	putrebactin, avaroferrin	Xenorhabdus budapestensis
BGC0000500.1	0.16	RiPP	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000942.1	0.15	Other	petrobactin	Bacillus anthracis str. Ames

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001498.1	0.55	Other	aerobactin	Xenorhabdus szentirmaii DSM 16338
BGC0001408.1	0.51	Other	xanthoferrin	Xanthomonas oryzae pv. oryzae KACC 10331
BGC0000939.1	0.47	Other	aerobactin	Grimontia hollisae
BGC0001587.1	0.47	Other	ethylenediaminesuccinic acid hydroxyarginine (EDHA)	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000504.1	0.47	RiPP	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000592.1	0.47	RiPP	microviridin B	Microcystis aeruginosa NIES-298
BGC0001576.1	0.46	RiPP	divamide A	Prochloron didemni
BGC0001870.1	0.46	Other	putrebactin, avaroferrin	Xenorhabdus budapestensis
BGC0000500.1	0.46	RiPP	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000942.1	0.45	Other	petrobactin	Bacillus anthracis str. Ames

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NC_010554.1 - Region 2 - thiopeptide

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Location: 759,220 - 785,699 nt. (total: 26,480 nt) Show pHMM detection rules used

thiopeptide: ((YcaO or TIGR03882) and ((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or PF07366 or PF06968 or PF04055) or thiostrepton)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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MIBiG comparison

KnownClusterBlast

Thiopeptides

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000781.1	0.23	Saccharide	O-antigen	Pseudomonas aeruginosa
BGC0001973.1	0.13	Other	fervenulin	Streptomyces hiroshimensis
BGC0001972.1	0.13	Other	toxoflavin, fervenulin	Streptomyces hiroshimensis
BGC0001285.1	0.07	Other (Fatty acid)	pseudopyronine A, pseudopyronine B	Pseudomonas putida
BGC0001954.1	0.06	NRP, Polyketide	wortmanamide A, wortmanamide B	Talaromyces wortmannii
BGC0001336.1	0.06	Alkaloid	erdasporine A, erdasporine B, erdasporine C	uncultured bacterium
BGC0000275.1	0.06	Polyketide	tetracenomycin C	Streptomyces glaucescens
BGC0000981.1	0.06	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 10E6
BGC0001988.1	0.04	Polyketide	neosartorin	Aspergillus novofumigatus IBT 16806
BGC0002012.1	0.04	Polyketide	julichrome Q3-3, julichrome Q3-5	Streptomyces afghaniensis 772

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000781.1	0.56	Saccharide	O-antigen	Pseudomonas aeruginosa
BGC0001973.1	0.41	Other	fervenulin	Streptomyces hiroshimensis
BGC0001972.1	0.41	Other	toxoflavin, fervenulin	Streptomyces hiroshimensis
BGC0001285.1	0.29	Other (Fatty acid)	pseudopyronine A, pseudopyronine B	Pseudomonas putida
BGC0001954.1	0.26	NRP, Polyketide	wortmanamide A, wortmanamide B	Talaromyces wortmannii
BGC0001336.1	0.26	Alkaloid	erdasporine A, erdasporine B, erdasporine C	uncultured bacterium
BGC0000275.1	0.25	Polyketide	tetracenomycin C	Streptomyces glaucescens
BGC0000981.1	0.24	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 10E6
BGC0001988.1	0.20	Polyketide	neosartorin	Aspergillus novofumigatus IBT 16806
BGC0002012.1	0.20	Polyketide	julichrome Q3-3, julichrome Q3-5	Streptomyces afghaniensis 772

Similar known gene clusters

No matches found.

Thiopeptide predictions

No core peptides found.

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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Thiopeptides

Core peptide predictions

No core peptides found.

NC_010554.1 - Region 3 - betalactone

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Location: 2,236,231 - 2,261,955 nt. (total: 25,725 nt) Show pHMM detection rules used

betalactone: (HMGL-like and AMP-binding)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001859.1	0.24	Other (Phosphonate)	fosfomycin	Pseudomonas syringae
BGC0000231.1	0.17	Polyketide	griseusin	Streptomyces griseus
BGC0000904.1	0.15	Other	FR-900098	Streptomyces rubellomurinus
BGC0000375.1	0.15	NRP	indigoidine	Streptomyces chromofuscus
BGC0001156.1	0.15	Terpene	platencin	Streptomyces platensis
BGC0001441.1	0.15	Other	belactosin A, belactosin C	Streptomyces sp.
BGC0001928.1	0.15	Other	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0001140.1	0.15	Terpene	platensimycin, platencin	Streptomyces platensis
BGC0000010.1	0.15	Polyketide	aflatoxin	Aspergillus flavus
BGC0000207.1	0.15	Polyketide	chartreusin	Streptomyces chartreusis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001859.1	0.57	Other (Phosphonate)	fosfomycin	Pseudomonas syringae
BGC0000231.1	0.49	Polyketide	griseusin	Streptomyces griseus
BGC0000904.1	0.45	Other	FR-900098	Streptomyces rubellomurinus
BGC0000375.1	0.45	NRP	indigoidine	Streptomyces chromofuscus
BGC0001156.1	0.45	Terpene	platencin	Streptomyces platensis
BGC0001441.1	0.45	Other	belactosin A, belactosin C	Streptomyces sp.
BGC0001928.1	0.45	Other	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0001140.1	0.45	Terpene	platensimycin, platencin	Streptomyces platensis
BGC0000010.1	0.45	Polyketide	aflatoxin	Aspergillus flavus
BGC0000207.1	0.44	Polyketide	chartreusin	Streptomyces chartreusis

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NC_010554.1 - Region 4 - NRPS,T1PKS

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Location: 2,814,947 - 2,870,279 nt. (total: 55,333 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000467.1	0.57	NRP	yersiniabactin	Yersinia enterocolitica
BGC0001560.1	0.48	NRP, Polyketide	cryptomaldamide	Moorea producens JHB
BGC0001415.1	0.43	NRP	althiomycin	Serratia marcescens subsp. marcescens Db11
BGC0001699.1	0.42	Polyketide	nidulanin A	Aspergillus nidulans FGSC A4
BGC0000412.1	0.41	NRP	pyochelin	Pseudomonas aeruginosa PAO1
BGC0000373.1	0.40	NRP	holomycin	Streptomyces clavuligerus ATCC 27064
BGC0001615.1	0.40	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0001641.1	0.40	NRP	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001131.1	0.40	NRP	ambactin	Xenorhabdus miraniensis
BGC0001758.1	0.40	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000467.1	0.62	NRP	yersiniabactin	Yersinia enterocolitica
BGC0001560.1	0.57	NRP, Polyketide	cryptomaldamide	Moorea producens JHB
BGC0001415.1	0.54	NRP	althiomycin	Serratia marcescens subsp. marcescens Db11
BGC0001699.1	0.54	Polyketide	nidulanin A	Aspergillus nidulans FGSC A4
BGC0000410.1	0.53	NRP	pseudomonine	Pseudomonas fluorescens
BGC0000412.1	0.53	NRP	pyochelin	Pseudomonas aeruginosa PAO1
BGC0000373.1	0.53	NRP	holomycin	Streptomyces clavuligerus ATCC 27064
BGC0001615.1	0.53	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0001641.1	0.53	NRP	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001131.1	0.53	NRP	ambactin	Xenorhabdus miraniensis

Similar known gene clusters

No matches found.

Module view

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Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 4, location 2814946 - 2870279:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (cys) + (Me-ohmal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 5, location 2814946 - 2861051:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (cys) + (Me-ohmal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 6, location 2821063 - 2870279:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (cys) + (Me-ohmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_2541

Search NORINE for peptide: strict or relaxed

AMP-binding (561..952): cys

NRPSPredictor2: cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: cys
Small clusters prediction:: cys
Single AA prediction:: cys

Stachelhaus prediction details:

Stachelhaus sequence:: DLYNySMIWK
Nearest Stachelhaus code:: cys
Stachelhaus code match:: 90% (moderate)

ctg1_2542

PKS_AT (539..813): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 68.1
Methoxymalonyl-CoA: 59.7
inactive: 43.5
Methylmalonyl-CoA: 43.5
Propionyl-CoA: 39.2
Isobutyryl-CoA: 30.9
Benzoyl-CoA: 30.9
Acetyl-CoA: 21.7
2-Methylbutyryl-CoA: 21.4
CHC-CoA: 20.0
3-Methylbutyryl-CoA: 17.1
trans-1,2-CPDA: 16.8
Ethylmalonyl-CoA: 15.0
fatty_acid: 14.7

NC_010554.1 - Region 5 - ladderane

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Location: 3,168,388 - 3,210,949 nt. (total: 42,562 nt) Show pHMM detection rules used

ladderane: ladderane

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001343.1	0.26	Polyketide	aurachin A, aurachin D	Stigmatella aurantiaca Sg a15
BGC0001184.1	0.26	Other	bacilysin	Bacillus velezensis FZB42
BGC0000888.1	0.26	Other	bacilysin	Bacillus sp. CS93
BGC0002000.1	0.24	Polyketide	setomimycin	Streptomyces aurantiacus JA 4570
BGC0001197.1	0.23	Polyketide	frankiamicin	Frankia sp. EAN1pec
BGC0001281.1	0.22	Polyketide	ustilagic acid	Ustilago maydis 521
BGC0002016.1	0.22	Polyketide	lugdunomycin	Streptomyces sp. QL37
BGC0001591.1	0.21	Other	fatty acid enol ester	uncultured bacterium CSLC2
BGC0001688.1	0.21	Other	N-tetradecanoyl tyrosine	uncultured bacterium CSLC2
BGC0000495.1	0.20	RiPP	actagardine	Actinoplanes garbadinensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001343.1	0.60	Polyketide	aurachin A, aurachin D	Stigmatella aurantiaca Sg a15
BGC0001184.1	0.60	Other	bacilysin	Bacillus velezensis FZB42
BGC0000888.1	0.60	Other	bacilysin	Bacillus sp. CS93
BGC0002000.1	0.58	Polyketide	setomimycin	Streptomyces aurantiacus JA 4570
BGC0001197.1	0.56	Polyketide	frankiamicin	Frankia sp. EAN1pec
BGC0001281.1	0.55	Polyketide	ustilagic acid	Ustilago maydis 521
BGC0002016.1	0.54	Polyketide	lugdunomycin	Streptomyces sp. QL37
BGC0001591.1	0.54	Other	fatty acid enol ester	uncultured bacterium CSLC2
BGC0001688.1	0.54	Other	N-tetradecanoyl tyrosine	uncultured bacterium CSLC2
BGC0000495.1	0.53	RiPP	actagardine	Actinoplanes garbadinensis

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names